PAX5

Summary

Gene Symbol: PAX5
Description: paired box 5
Alias: ALL3, BSAP, paired box protein Pax-5, B-cell lineage specific activator, paired box homeotic gene 5, paired domain gene 5, transcription factor PAX 5
Species: human
Products:     PAX5

Top Publications

  1. Torlakovic E, Slipicevic A, Robinson C, DeCoteau J, Alfsen G, Vyberg M, et al. Pax-5 expression in nonhematopoietic tissues. Am J Clin Pathol. 2006;126:798-804 pubmed
  2. Familiades J, Bousquet M, Lafage Pochitaloff M, Bene M, Beldjord K, De Vos J, et al. PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: a GRAALL study. Leukemia. 2009;23:1989-98 pubmed publisher
    ..A genome-wide analysis using oligo SNP arrays recently demonstrated that PAX5 (paired-box domain 5) is the main target of somatic mutations in childhood BCP-ALL being altered in 38...
  3. Iacobucci I, Lonetti A, Paoloni F, Papayannidis C, Ferrari A, Storlazzi C, et al. The PAX5 gene is frequently rearranged in BCR-ABL1-positive acute lymphoblastic leukemia but is not associated with outcome. A report on behalf of the GIMEMA Acute Leukemia Working Party. Haematologica. 2010;95:1683-90 pubmed publisher
    ..of DNA copy number abnormalities using single nucleotide polymorphism microarrays, genetic alterations targeting PAX5 were identified in over 30% of pediatric patients with acute lymphoblastic leukemia...
  4. Busslinger M, Klix N, Pfeffer P, Graninger P, Kozmik Z. Deregulation of PAX-5 by translocation of the Emu enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma. Proc Natl Acad Sci U S A. 1996;93:6129-34 pubmed
    ..These data suggest that deregulation of PAX-5 gene transcription by the t(9;14)(pl3;q32) translocation contributes to the pathogenesis of small lymphocytic lymphomas with plasmacytoid differentiation. ..
  5. Nutt S, Heavey B, Rolink A, Busslinger M. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature. 1999;401:556-62 pubmed
    The Pax5 gene encoding the B-cell-specific activator protein (BSAP) is expressed within the haematopoietic system exclusively in the B-lymphoid lineage, where it is required in vivo for progression beyond the pro-B-cell stage...
  6. Tzankov A, Went P, Münst S, Papadopoulos T, Jundt G, Dirnhofer S. Rare expression of BSAP (PAX-5) in mature T-cell lymphomas. Mod Pathol. 2007;20:632-7 pubmed
    ..the assessment of lineage-specific markers, such as the B-cell-specific activator protein of the paired box family (BSAP, PAX-5) for the B-cell lineage...
  7. An Q, Wright S, Konn Z, Matheson E, Minto L, Moorman A, et al. Variable breakpoints target PAX5 in patients with dicentric chromosomes: a model for the basis of unbalanced translocations in cancer. Proc Natl Acad Sci U S A. 2008;105:17050-4 pubmed publisher
    ..showed that, although they were heterogeneous, breakpoints on 9p resulted in the partial or complete deletion of PAX5. Molecular copy number counting further delineated the breakpoints and facilitated cloning with long-distance ..
  8. Liu W, Li X, Chu E, Go M, Xu L, Zhao G, et al. Paired box gene 5 is a novel tumor suppressor in hepatocellular carcinoma through interaction with p53 signaling pathway. Hepatology. 2011;53:843-53 pubmed publisher
    The paired box 5 (PAX5) is a member of PAX transcription factors family involved in the regulation of embryonic development. However, the role of PAX5 in carcinogenesis is largely unclear...
  9. Li X, Cheung K, Ma X, Tian L, Zhao J, Go M, et al. Epigenetic inactivation of paired box gene 5, a novel tumor suppressor gene, through direct upregulation of p53 is associated with prognosis in gastric cancer patients. Oncogene. 2012;31:3419-30 pubmed publisher
    Using genome-wide methylation screening, we identified that paired box gene 5 (PAX5) is involved in human cancer development. However, the function of PAX5 in gastric cancer (GC) development is largely unclear...

More Information

Publications102 found, 100 shown here

  1. Kovac C, Emelyanov A, Singh M, Ashouian N, Birshtein B. BSAP (Pax5)-importin alpha 1 (Rch1) interaction identifies a nuclear localization sequence. J Biol Chem. 2000;275:16752-7 pubmed
    BSAP (Pax5) is an essential transcription factor for early B cell and central nervous system development. In later B cell development, BSAP has been implicated in the regulation of 3' Ig enhancers and a number of B cell-specific genes...
  2. Robichaud G, Nardini M, Laflamme M, Cuperlovic Culf M, Ouellette R. Human Pax-5 C-terminal isoforms possess distinct transactivation properties and are differentially modulated in normal and malignant B cells. J Biol Chem. 2004;279:49956-63 pubmed
    ..Finally, we demonstrate, for the first time, that human Pax-5 isoform expression is modulated by specific signaling pathways in B lymphocytes. ..
  3. Tiacci E, Pileri S, Orleth A, Pacini R, Tabarrini A, Frenguelli F, et al. PAX5 expression in acute leukemias: higher B-lineage specificity than CD79a and selective association with t(8;21)-acute myelogenous leukemia. Cancer Res. 2004;64:7399-404 pubmed
    The transcription factor PAX5 plays a key role in the commitment of hematopoietic precursors to the B-cell lineage, but its expression in acute leukemias has not been thoroughly investigated...
  4. Mullighan C, Goorha S, Radtke I, Miller C, Coustan Smith E, Dalton J, et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature. 2007;446:758-64 pubmed
    ..The PAX5 gene was the most frequent target of somatic mutation, being altered in 31.7% of cases...
  5. Nebral K, Denk D, Attarbaschi A, Konig M, Mann G, Haas O, et al. Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia. Leukemia. 2009;23:134-43 pubmed publisher
    b>PAX5, a master regulator of B-cell development, was recently shown to be involved in several leukemia-associated rearrangements, which result in fusion genes encoding chimeric proteins that antagonize PAX5 transcriptional activity...
  6. Coyaud E, Struski S, Prade N, Familiades J, Eichner R, Quelen C, et al. Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study. Blood. 2010;115:3089-97 pubmed publisher
    b>PAX5 is the main target of somatic mutations in acute B lymphoblastic leukemia (B-ALL)...
  7. Heltemes Harris L, Willette M, Ramsey L, Qiu Y, Neeley E, Zhang N, et al. Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia. J Exp Med. 2011;208:1135-49 pubmed publisher
    ..Mutations in EBF1 and PAX5, genes critical for B cell development have also been identified in human ALL...
  8. O Brien P, Morin P, Ouellette R, Robichaud G. The Pax-5 gene: a pluripotent regulator of B-cell differentiation and cancer disease. Cancer Res. 2011;71:7345-50 pubmed publisher
    ..Given the pivotal importance of Pax-5-mediated processes in B-cell development, an aberrant regulation of Pax5 expression has consistently been associated with B-cell cancers, namely, lymphoma and lymphocytic leukemias...
  9. Hagman J, Wheat W, Fitzsimmons D, Hodsdon W, Negri J, Dizon F. Pax-5/BSAP: regulator of specific gene expression and differentiation in B lymphocytes. Curr Top Microbiol Immunol. 2000;245:169-94 pubmed
  10. Fortschegger K, Anderl S, Denk D, Strehl S. Functional heterogeneity of PAX5 chimeras reveals insight for leukemia development. Mol Cancer Res. 2014;12:595-606 pubmed publisher
    b>PAX5, a transcription factor pivotal for B-cell commitment and maintenance, is one of the most frequent targets of somatic mutations in B-cell precursor acute lymphoblastic leukemia...
  11. Adams B, Dörfler P, Aguzzi A, Kozmik Z, Urbanek P, Maurer Fogy I, et al. Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes Dev. 1992;6:1589-607 pubmed
    b>BSAP has been identified previously as a transcription factor that is expressed at early, but not late, stages of B-cell differentiation...
  12. Eberhard D, Jimenez G, Heavey B, Busslinger M. Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family. EMBO J. 2000;19:2292-303 pubmed
    b>Pax5 (BSAP) functions as both a transcriptional activator and repressor during midbrain patterning, B-cell development and lymphomagenesis...
  13. Lazzi S, Bellan C, Onnis A, De Falco G, Sayed S, Kostopoulos I, et al. Rare lymphoid neoplasms coexpressing B- and T-cell antigens. The role of PAX-5 gene methylation in their pathogenesis. Hum Pathol. 2009;40:1252-61 pubmed publisher
    ..A characteristic of our cases was the lack of expression of the specific B-cell transcription factor, Pax5, which is essential for maintaining the identity and function of mature B cells during late B lymphopoiesis...
  14. Kolhe R, Reid M, Lee J, Cohen C, Ramalingam P. Immunohistochemical expression of PAX5 and TdT by Merkel cell carcinoma and pulmonary small cell carcinoma: a potential diagnostic pitfall but useful discriminatory marker. Int J Clin Exp Pathol. 2013;6:142-7 pubmed
    ..The aim of our study was to evaluate and compare the expression of PAX5 and Terminal deoxynucleotidyl transferase (TdT), in Merkel cell carcinoma and pulmonary small cell carcinoma...
  15. Wang C, Zhou H, Xue Y, Liang J, Narita Y, Gerdt C, et al. Epstein-Barr Virus Nuclear Antigen Leader Protein Coactivates EP300. J Virol. 2018;92: pubmed publisher
    ..had significantly higher ChIP-seq signals for sequence-specific TFs, including SPI1, RelA, EBF1, IRF4, BATF, and PAX5. EBNALP- and EP300-cooccurring sites also had much higher H3K4me1 and H3K27ac signals, indicative of activated ..
  16. Shao H, Xi L, Raffeld M, Feldman A, Ketterling R, Knudson R, et al. Clonally related histiocytic/dendritic cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a study of seven cases. Mod Pathol. 2011;24:1421-32 pubmed publisher
    ..Compared with the CLL/SLL cells, the histiocytic/dendritic cells were largely negative for PAX5, but showed strong expression of PU.1 and variable and weak expression of CEBPβ...
  17. Zhu J, Wang Y, Gong L, Huang G. Diagnosis of primary pulmonary T- cell/histiocyte-rich large B cell lymphoma with tissue eosinophilia via clinicopathological observation and molecular assay. Diagn Pathol. 2014;9:188 pubmed publisher
    ..expressed CD3; the large lymphoid cells expressed CD20 and some scattered large lymphoid cells expressed Pax5. However, molecular studies confirmed clonal immunoglobulin heavy chain (IGH)-D gene rearrangement in Pax5-positive ..
  18. Yang R, Klimentova J, Göckel Krzikalla E, Ly R, Gmelin N, Hotz Wagenblatt A, et al. Combined Transcriptome and Proteome Analysis of Immortalized Human Keratinocytes Expressing Human Papillomavirus 16 (HPV16) Oncogenes Reveals Novel Key Factors and Networks in HPV-Induced Carcinogenesis. mSphere. 2019;4: pubmed publisher
    ..We identified potential novel upstream regulators (e.g., CNOT7, SPDEF, MITF, and PAX5) controlling distinct clusters of genes within the HPV-host cell network as well as distinct factors (e.g...
  19. Kambas A, Leontsini D, Avloniti A, Chatzinikolaou A, Stampoulis T, Makris K, et al. Physical activity may be a potent regulator of bone turnover biomarkers in healthy girls during preadolescence. J Bone Miner Metab. 2017;35:598-607 pubmed publisher
    ..Blood was collected for the measurement of alkaline phosphatase (ALP), bone-specific ALP (BSAP), procollagen type I N-terminal propeptide (PINP), C-terminal telopeptide of collagen I (CTX), parathyroid ..
  20. Martin L, Hoppé E, Kauffenstein G, Omarjee L, Navasiolava N, Henni S, et al. Early arterial calcification does not correlate with bone loss in pseudoxanthoma elasticum. Bone. 2017;103:88-92 pubmed publisher
    ..Markers of bone remodelling processes (CTX, BSAP and osteocalcin) were within the normal range for our laboratory standards...
  21. Zhao X, Wang H, Zhao X, Cheng H, Li W, Liu S, et al. [Study on Immunophenotypes and Gene of Acute Lymphoblastic Leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018;26:947-952 pubmed publisher
    ..AML1-ETO, PML-RARα and so on) were qualitative screened and ALL gene mutations(IKZF1, TP53, PAX5, JAK1, JAK2, CRLF2, PHF6, NOTCH1, FBXW7, PTEN)were detected by next generation sequencing(NGS)...
  22. Wang J, New J, Xie S, Yang P, Wu Q, Li J, et al. Extension of the germinal center stage of B cell development promotes autoantibodies in BXD2 mice. Arthritis Rheum. 2013;65:2703-12 pubmed publisher
    ..X-box binding protein 1 and the p-CREB target genes Fosb and Obf1, and down-regulation of the GC program genes Aid, Pax5, and Bach2 compared to BXD2 mice...
  23. White C, Pone E, Lam T, Tat C, Hayama K, Li G, et al. Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responses. J Immunol. 2014;193:5933-50 pubmed publisher
    ..important inducers/modulators of AICDA/Aicda), Rev1 and Ung (central elements for CSR/SHM), and Bcl6, Bach2, or Pax5 (repressors of PRDM1/Prdm1 expression), as well as unchanged expression of miR-19a/b, miR-20a, and miR-25, which ..
  24. Slawinska A, Plowiec A, Siwek M, Jaroszewski M, Bednarczyk M. Long-Term Transcriptomic Effects of Prebiotics and Synbiotics Delivered In Ovo in Broiler Chickens. PLoS ONE. 2016;11:e0168899 pubmed publisher
    ..CA7), signaling (FGG, G3BP2, UBB, G3BP2, CACNA1G, and ATP6V0A4), and immune responses (MSMB, LGALS3, CABIN1, CXCR5, PAX5, and TNFRSF14). Two DEG influencing the complement system (SERPING1 and MIR1674) were down-regulated in P2 and S1...
  25. Quwaider D, Corchete L, Misiewicz Krzeminska I, Sarasquete M, Perez J, Krzeminski P, et al. DEPTOR maintains plasma cell differentiation and favorably affects prognosis in multiple myeloma. J Hematol Oncol. 2017;10:92 pubmed publisher
    ..in H929 and MM1S cell lines induced dedifferentiation of myeloma cells, as demonstrated by the upregulation of PAX5 and BCL6, the downregulation of IRF4, and a clear reduction in cell size and endoplasmic reticulum mass...
  26. Dong H, Browne P, Liu Z, Gangi M. PAX-5 is invariably expressed in B-cell lymphomas without plasma cell differentiation. Histopathology. 2008;53:278-87 pubmed publisher
    ..PAX-5 is the most sensitive and reliable immunohistochemical marker for B-cell malignancies. Lack of PAX-5 expression correlates with the presence of marked plasma cell differentiation. ..
  27. Kurahashi S, Hayakawa F, Miyata Y, Yasuda T, Minami Y, Tsuzuki S, et al. PAX5-PML acts as a dual dominant-negative form of both PAX5 and PML. Oncogene. 2011;30:1822-30 pubmed publisher
    b>PAX5 is a transcription factor required for B-cell development and maintenance. PML is a tumor suppressor and a pro-apoptotic factor...
  28. Smeenk L, Fischer M, Jurado S, Jaritz M, Azaryan A, Werner B, et al. Molecular role of the PAX5-ETV6 oncoprotein in promoting B-cell acute lymphoblastic leukemia. EMBO J. 2017;36:718-735 pubmed publisher
    b>PAX5 is a tumor suppressor in B-ALL, while the role of PAX5 fusion proteins in B-ALL development is largely unknown. Here, we studied the function of PAX5-ETV6 and PAX5-FOXP1 in mice expressing these proteins from the Pax5 locus...
  29. Eberhard D, Busslinger M. The partial homeodomain of the transcription factor Pax-5 (BSAP) is an interaction motif for the retinoblastoma and TATA-binding proteins. Cancer Res. 1999;59:1716s-1724s; discussion 1724s-1725s pubmed
    Pax-5 codes for the transcription factor BSAP, which plays an important role in midbrain patterning, B cell development, and lymphoma formation...
  30. Martinez D, Navarro A, Martínez Trillos A, Molina Urra R, González Farre B, Salaverria I, et al. NOTCH1, TP53, and MAP2K1 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma Are Associated With Progressive Disease. Am J Surg Pathol. 2016;40:192-201 pubmed publisher
    ..Cytogenetic and molecular studies identified complex karyotypes in 2 cases, and IGH rearrangements in 3, with PAX5 and potentially TCL1 as partners in each one of them...
  31. Schmäh J, Fedders B, Panzer Grümayer R, Fischer S, Zimmermann M, Dagdan E, et al. Molecular characterization of acute lymphoblastic leukemia with high CRLF2 gene expression in childhood. Pediatr Blood Cancer. 2017;64: pubmed publisher
    ..were characterized by a high frequency of additional deletions in B-cell differentiation genes such as IKZF1 or PAX5. Our data suggest that this high frequency of genetic aberrations in the context of a high CRLF2 expression could ..
  32. Feng J, Liu X, Ni X, Qi H. External signals regulate germinal center fate-determining transcription factors in the A20 lymphoma cell line. Mol Immunol. 2018;93:79-86 pubmed publisher
    ..However, only BCR signaling downregulate PAX5 and BACH2, two transcription factors that help maintain the GCB identity...
  33. Denzinger S, Burger M, Hammerschmied C, Wieland W, Hartmann A, Obermann E, et al. Pax-5 protein expression in bladder cancer: a preliminary study that shows no correlation to grade, stage or clinical outcome. Pathology. 2008;40:465-9 pubmed publisher
    ..Pax-5 positive lymphocytes within reactive infiltrates adjacent to the tumour warrant further studies evaluating biological, immunological and clinical relevance. ..
  34. Mullighan C, Su X, Zhang J, Radtke I, Phillips L, Miller C, et al. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med. 2009;360:470-80 pubmed publisher
    ..8% of patients in the original cohort); PAX5 was involved in 31.7% and IKZF1 in 28.6% of patients...
  35. Patel S, Mason C, Glenn M, Paxton C, South S, Cessna M, et al. Genomic analysis of adult B-ALL identifies potential markers of shorter survival. Leuk Res. 2017;56:44-51 pubmed publisher
    ..We confirmed previous findings that the most prevalent deletions of these genes occur in CDKN2A, IKZF1, and PAX5, with several others at lower frequencies...
  36. Bhandari P, Ahmad F, Das B. Molecular profiling of gene copy number abnormalities in key regulatory genes in high-risk B-lineage acute lymphoblastic leukemia: frequency and their association with clinicopathological findings in Indian patients. Med Oncol. 2017;34:92 pubmed publisher
    ..Frequent genes deletions included CDNK2A/B (26%), IKZF1 (25%), PAX5 (14%), JAK2 (7%), BTG1 (6%), RB1 (5%), EBF1 (4%), ETV6 (4%), while PAR1 region genes were predominantly duplicated (..
  37. Lee S, Ji Y, Kim H, Ki C, Jung C, Kim J, et al. Sequential array comparative genomic hybridization analysis identifies copy number changes during blastic transformation of chronic myeloid leukemia. Leuk Res. 2012;36:418-21 pubmed publisher
    ..In addition, we identified a novel fusion gene consisted of PAX5 and MLLT3 (AF9)...
  38. Duque Afonso J, Feng J, Scherer F, Lin C, Wong S, Wang Z, et al. Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia. J Clin Invest. 2015;125:3667-80 pubmed publisher
    ..and led to acquisition of multiple secondary genomic aberrations, including prominent spontaneous loss of Pax5. In preleukemic mice, conditional Pax5 deletion cooperated with E2A-PBX1 to expand progenitor B cell subpopulations,..
  39. AbdullGaffar B, Seliem R. De Novo Unclassifiable CD20-Negative Diffuse Large B-Cell Lymphoma: A Diagnostic and Therapeutic Challenge. Int J Surg Pathol. 2017;:1066896917735170 pubmed publisher
    ..The nodal neoplastic immunoblasts were positive for LCA, PAX5, CD30, OCT2, BOB1, MUM1, CD79a, and CD19. Ki67 proliferation index was 100%...
  40. Mohri T, Ikura Y, Hirakoso A, Okamoto M, Hishizawa M, Takaori Kondo A, et al. Classical Hodgkin lymphoma type post-transplant lymphoproliferative disorder in a kidney transplant recipient: a diagnostic pitfall. Int J Hematol. 2018;108:218-227 pubmed publisher
    ..were positive for Epstein-Barr Virus (EBV)-encoded small RNAs (EBER) in situ hybridization, EBV-LMP1, CD30 and PAX5, but negative for CD15, CD20 and CD45...
  41. Lee N, Moss W, Yario T, Steitz J. EBV noncoding RNA binds nascent RNA to drive host PAX5 to viral DNA. Cell. 2015;160:607-618 pubmed publisher
    ..TRs) of the latent EBV genome, overlapping previously identified binding sites for the B cell transcription factor PAX5. EBER2 interacts with PAX5 and is required for the localization of PAX5 to the TRs...
  42. Ezeh P, Xu H, Lauer F, Liu K, Hudson L, Burchiel S. Monomethylarsonous acid (MMA+3) Inhibits IL-7 Signaling in Mouse Pre-B Cells. Toxicol Sci. 2016;149:289-99 pubmed publisher
    ..of STAT5, we found that the induction of several genes required in B cell development, cyclin D1, E2A, EBF1, and PAX5, were selectively inhibited by MMA(+3)...
  43. Vinci L, Ravarino A, Fanos V, Naccarato A, Senes G, Gerosa C, et al. Immunohistochemical markers of neural progenitor cells in the early embryonic human cerebral cortex. Eur J Histochem. 2016;60:2563 pubmed publisher
    ..embedded and immunostained with several markers including GFAP, WT1, Nestin, Vimentin, CD117, S100B, Sox2, PAX2, PAX5, Tβ4, Neurofilament, CD44, CD133, Synaptophysin and Cyclin D1...
  44. Scheijen B, Boer J, Marke R, Tijchon E, van Ingen Schenau D, Waanders E, et al. Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients. Haematologica. 2017;102:541-551 pubmed publisher
    ..other copy number losses commonly observed in B-cell precursor acute lymphoblastic leukemia, such as CDKN2A/B, PAX5, EBF1 or RB1, did not affect the outcome of IKZF1-deleted acute lymphoblastic leukemia patients...
  45. Vaishampayan U, Tehrani O, Lawhorn Crews J, Heilbrun L, Dobson K, Smith D, et al. A Pilot Trial Evaluating Zoledronic Acid Induced Changes in [18F]FMAU-Positron Emission Tomography Imaging of Bone Metastases in Prostate Cancer. Mol Imaging Biol. 2017;19:810-816 pubmed publisher
    ..NTx) was markedly decreased in all patients after zoledronic acid and serum bone-specific alkaline phosphatase (BSAP) registered a modest change. Urine NTx correlated more closely with SUV max than serum BSAP...
  46. Hayashi M, Guerrero Preston R, Sidransky D, Koch W. Paired box 5 methylation detection by droplet digital PCR for ultra-sensitive deep surgical margins analysis of head and neck squamous cell carcinoma. Cancer Prev Res (Phila). 2015;8:1017-26 pubmed publisher
    ..quantitative methylation-specific PCR (QMSP) and QMSP by droplet digital PCR (ddQMSP) targeting Paired box 5 (PAX5) gene promoter methylation...
  47. Perez Borrajero C, Okon M, McIntosh L. Structural and Dynamics Studies of Pax5 Reveal Asymmetry in Stability and DNA Binding by the Paired Domain. J Mol Biol. 2016;428:2372-2391 pubmed publisher
    The eukaryotic transcription factor Pax5 or B-cell specific activator protein (BSAP) is central to B-cell development and has been implicated in a large number of cellular malignancies resulting from loss- or gain-of-function mutations...
  48. Wang D, Chen J, Li R, Wu G, Sun Z, Wang Z, et al. PAX5 interacts with RIP2 to promote NF-?B activation and drug-resistance in B-lymphoproliferative disorders. J Cell Sci. 2016;129:2261-72 pubmed publisher
    Paired box protein 5 (PAX5) plays a lineage determination role in B-cell development...
  49. Sakamoto K, Imamura T, Kanayama T, Yano M, Asai D, Deguchi T, et al. Ph-like acute lymphoblastic leukemia with a novel PAX5-KIDINS220 fusion transcript. Genes Chromosomes Cancer. 2017;56:278-284 pubmed publisher
    Although "paired box 5" (PAX5)-related fusion genes are well documented in childhood B-cell precursor acute lymphoblastic leukemia (ALL), these types of fusion with the exception of PAX5-JAK2 are rarely seen in patients with gene ..
  50. Maurya S, Mishra R. Co-Localization and Interaction of Pax5 with Iba1 in Brain of Mice. Cell Mol Neurobiol. 2018;38:919-927 pubmed publisher
    The Pax5, a B-cell-Specific Activator Protein (BSAP) and redox-sensitive transcription factor, is expressed in the immune-privileged brain, B-lymphocytes, lymph nodes and spleen...
  51. Stapleton P, Weith A, Urbanek P, Kozmik Z, Busslinger M. Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9. Nat Genet. 1993;3:292-8 pubmed
    ..PAX-1 and PAX-7 map to chromosomal regions containing previously assigned disease loci. ..
  52. Garvie C, Hagman J, Wolberger C. Structural studies of Ets-1/Pax5 complex formation on DNA. Mol Cell. 2001;8:1267-76 pubmed
    b>Pax5 regulates the B cell-specific expression of the mb-1 gene together with members of the Ets family of transcriptional activators...
  53. Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
    ..The CD markers correlated with immunophenotypic categories as expected. From non-CD markers, we found DBN1, PAX5, or PTK2 overexpressed in B-cell precursor acute lymphoblastic leukemias, LAT, SH2D1A, or STAT5A overexpressed in T-..
  54. Tsuprykov O, Buse C, Skoblo R, Haq A, Hocher B. Reference intervals for measured and calculated free 25-hydroxyvitamin D in normal pregnancy. J Steroid Biochem Mol Biol. 2018;181:80-87 pubmed publisher
    ..All 25(OH)D isoforms were significantly negatively correlated with bone-specific alkaline phosphatase (BSAP), however the correlation strength was the lowest with total 25(OH)D (rho = -0.108, p = 0...
  55. Calame K, Lin K, Tunyaplin C. Regulatory mechanisms that determine the development and function of plasma cells. Annu Rev Immunol. 2003;21:205-30 pubmed
    ..Transcription factors Bcl-6 and Pax5, which are required for germinal center B cells, block plasmacytic differentiation and repress Blimp-1 and XBP-1, ..
  56. Traverse Glehen A, Verney A, Baseggio L, Felman P, Callet Bauchu E, Thieblemont C, et al. Analysis of BCL-6, CD95, PIM1, RHO/TTF and PAX5 mutations in splenic and nodal marginal zone B-cell lymphomas suggests a particular B-cell origin. Leukemia. 2007;21:1821-4 pubmed
  57. Prieto J, Tallmadge R, Felippe M. Developmental expression of B cell molecules in equine lymphoid tissues. Vet Immunol Immunopathol. 2017;183:60-71 pubmed publisher
    ..markers (CD2, CD21, IgM) measured using flow cytometry, but similar mRNA expression of signature genes (DGKA, FGL2, PAX5, IGHM, IL10) measured using quantitative RT-PCR...
  58. Arbajian E, Puls F, Antonescu C, Amary F, Sciot R, Debiec Rychter M, et al. In-depth Genetic Analysis of Sclerosing Epithelioid Fibrosarcoma Reveals Recurrent Genomic Alterations and Potential Treatment Targets. Clin Cancer Res. 2017;23:7426-7434 pubmed publisher
    ..RNA-seq identified FUS-CREM and PAX5-CREB3L1 as alternative fusion genes in one SEF each...
  59. Iida S, Rao P, Nallasivam P, Hibshoosh H, Butler M, Louie D, et al. The t(9;14)(p13;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5 gene. Blood. 1996;88:4110-7 pubmed
    ..These findings suggest that the PAX-5 gene is the target of the t(9;14) in LPL whereby its expression may be deregulated by juxtaposition to IgH regulatory elements, thus contributing to lymphomagenesis. ..
  60. Hansson M, Jerkeman M, Dictor M. Biphenotypic bigenotypic lymphoma with simultaneous expression of PAX5/BSAP and B- and T-cell markers. Eur J Haematol. 2007;79:159-65 pubmed
    ..Simultaneous nuclear expression of the transcription factor gene PAX5 suggested that this major driver of B-cell differentiation did not preclude expression of CD3epsilon, generally ..
  61. An Q, Wright S, Moorman A, Parker H, Griffiths M, Ross F, et al. Heterogeneous breakpoints in patients with acute lymphoblastic leukemia and the dic(9;20)(p11-13;q11) show recurrent involvement of genes at 20q11.21. Haematologica. 2009;94:1164-9 pubmed publisher
    ..b>PAX5 has been proposed to be the target gene on 9p, while for 20q, FISH analysis implicated the involvement of the ASXL1 ..
  62. Ray D, Kwon S, Tagoh H, Heidenreich O, Ptasinska A, Bonifer C. Lineage-inappropriate PAX5 expression in t(8;21) acute myeloid leukemia requires signaling-mediated abrogation of polycomb repression. Blood. 2013;122:759-69 pubmed publisher
    The activation of B-cell-specific genes, such as CD19 and PAX5, is a hallmark of t(8;21) acute myeloid leukemia (AML) which expresses the translocation product RUNX1/ETO...
  63. Li C, Gonsalves C, Eiymo Mwa Mpollo M, Malik P, Tahara S, Kalra V. MicroRNA 648 Targets ET-1 mRNA and is cotranscriptionally regulated with MICAL3 by PAX5. Mol Cell Biol. 2015;35:514-28 pubmed publisher
    ..P1) was the predominant promoter used for transcription of pre-miR-648, and it was under positive control by PAX5 (paired box protein 5) transcription factor, as demonstrated by the loss and gain of function of PAX5 activity, and ..
  64. Bharti B, Shukla S, Tripathi R, Mishra S, Kumar M, Pandey M, et al. Level of PAX5 in differential diagnosis of non-Hodgkin's lymphoma. Indian J Med Res. 2016;143:S23-S31 pubmed publisher
    The PAX5, a paired box transcription factor and B-cell activator protein (BSAP), activates B-cell commitment genes and represses non-B-cell lineage genes. About 14 transcript variants of PAX5 have been observed in human...
  65. Benzina S, Beauregard A, Guerrette R, Jean S, Faye M, Laflamme M, et al. Pax-5 is a potent regulator of E-cadherin and breast cancer malignant processes. Oncotarget. 2017;8:12052-12066 pubmed publisher
    ..We also present an important role for Pax-5 in the phenotypic transitioning processes and aggressive features associated with breast cancer malignancy and disease progression. ..
  66. Boya R, Yadavalli A, Nikhat S, Kurukuti S, Palakodeti D, Pongubala J. Developmentally regulated higher-order chromatin interactions orchestrate B cell fate commitment. Nucleic Acids Res. 2017;45:11070-11087 pubmed publisher
    ..Finally, we demonstrate the potential roles for Ebf1 and its downstream factor, Pax5, in chromatin reorganization and transcription regulation...
  67. Klenova E, Chernukhin I, Inoue T, Shamsuddin S, Norton J. Immunoprecipitation techniques for the analysis of transcription factor complexes. Methods. 2002;26:254-9 pubmed
    ..developed for detecting interactions between the helix-loop-helix protein, Id3, and the paired homeodomain protein, Pax5, and interactions involving the zinc finger transcription factor, CTCF...
  68. Merluzzi S, Moretti M, Altamura S, Zwollo P, Sigvardsson M, Vitale G, et al. CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism. J Biol Chem. 2004;279:1777-86 pubmed
    ..The transcription factors Pax5a or BSAP (B cell lineage-specific activator protein) and EBF (early B cell factor) are constitutively expressed in spleen B ..
  69. Gao H, Lukin K, Ramírez J, Fields S, Lopez D, Hagman J. Opposing effects of SWI/SNF and Mi-2/NuRD chromatin remodeling complexes on epigenetic reprogramming by EBF and Pax5. Proc Natl Acad Sci U S A. 2009;106:11258-63 pubmed publisher
    ..In turn, this facilitates promoter activation by Pax5. Here, we investigated the roles of ATP-dependent CRCs in these mechanisms...
  70. Narayansingh R, Ouellette R. Paired box gene 5 may modulate Proviral Integration of Moloney virus 2 gene and protein expression in mature B-cells. Leuk Lymphoma. 2011;52:887-95 pubmed publisher
    ..Taken together, these results suggest that Pax-5 may act as a transcription factor to modulate the expression of Pim-2 and that both proteins may play a role in the oncogenesis of mature B-cell lymphoma. ..
  71. Ribeiro I, Caramelo F, Marques F, Domingues A, Mesquita M, Barroso L, et al. WT1, MSH6, GATA5 and PAX5 as epigenetic oral squamous cell carcinoma biomarkers - a short report. Cell Oncol (Dordr). 2016;39:573-582 pubmed
    ..In addition, we found that PAX5 gene promoter methylation was significantly associated with tongue tumors...
  72. Perearnau A, Orlando S, Islam A, Gallastegui E, Martinez J, Jordan A, et al. p27Kip1, PCAF and PAX5 cooperate in the transcriptional regulation of specific target genes. Nucleic Acids Res. 2017;45:5086-5099 pubmed publisher
    ..We also observed that the transcription factor Pax5 interacts with both p27 and PCAF and that the knock down of Pax5 induces the expression of p27/PCAF target genes ..
  73. Fujita T, Kitaura F, Yuno M, Suzuki Y, Sugano S, Fujii H. Locus-specific ChIP combined with NGS analysis reveals genomic regulatory regions that physically interact with the Pax5 promoter in a chicken B cell line. DNA Res. 2017;24:537-548 pubmed publisher
    ..In this study, we attempted to identify genomic regions that physically bind to the promoter region of the Pax5 gene, which encodes a master regulator for B cell lineage commitment, in a chicken B cell line, DT40, with the goal ..
  74. Kishi H, Jin Z, Wei X, Nagata T, Matsuda T, Saito S, et al. Cooperative binding of c-Myb and Pax-5 activates the RAG-2 promoter in immature B cells. Blood. 2002;99:576-83 pubmed
    ..These results suggest that cooperative binding of c-Myb and Pax-5 to the RAG-2 promoter is one of the mechanisms to direct the restricted expression of the RAG-2 in immature B cells. ..
  75. Medina F, Segundo C, Campos Caro A, Gonzalez Garcia I, Brieva J. The heterogeneity shown by human plasma cells from tonsil, blood, and bone marrow reveals graded stages of increasing maturity, but local profiles of adhesion molecule expression. Blood. 2002;99:2154-61 pubmed
    ..However, PCs from these different organs showed a local pattern of adhesion molecule expression. These observations are discussed in light of the complex physiology of the human PC compartment. ..
  76. Jiang H, Gao W, Sze D, Xiong H, Hou J. Transcription factors Xbp-1, Blimp-1, and BSAP are involved in the regulation of plasmacytic differentiation induced by 2-methoxyestradiol in myeloma cell lines. Int J Hematol. 2007;86:429-37 pubmed publisher
    ..Xbp-1, B-lymphocyte induced maturation protein 1 (Blimp-1), and PAX-5-encoded B-cell-specific activator protein (BSAP), which are thought to be involved in the regulation of B-lymphocytic or plasmacytic differentiation...
  77. Feldman A, Law M, Inwards D, Dogan A, McClure R, Macon W. PAX5-positive T-cell anaplastic large cell lymphomas associated with extra copies of the PAX5 gene locus. Mod Pathol. 2010;23:593-602 pubmed publisher
    ..Staining for the B-cell transcription factor, paired box 5 (PAX5), has been suggested to be helpful in this differential, as it is positive in most classical Hodgkin's lymphomas, ..
  78. Proulx M, Cayer M, Drouin M, Laroche A, Jung D. Overexpression of PAX5 induces apoptosis in multiple myeloma cells. Int J Hematol. 2010;92:451-62 pubmed publisher
    b>PAX5 is an essential transcription factor for the commitment of lymphoid progenitors to the B-lymphocyte lineage...
  79. Qiu J, Chu H, Lu X, Jiang X, Dong S. The reduced and altered activities of PAX5 are linked to the protein-protein interaction motif (coiled-coil domain) of the PAX5-PML fusion protein in t(9;15)-associated acute lymphocytic leukemia. Oncogene. 2011;30:967-77 pubmed publisher
    The paired box domain of PAX5 was reported to fuse with the sequence of promyelocytic leukemia (PML) to produce PAX5-PML chimeric protein in two patients with B-cell acute lymphoblastic leukemia...
  80. Xue K, Song J, Yang Y, Li Z, Wu C, Jin J, et al. PAX5 promotes pre-B cell proliferation by regulating the expression of pre-B cell receptor and its downstream signaling. Mol Immunol. 2016;73:1-9 pubmed publisher
    b>PAX5 is indispensable for the commitment of early lymphoid progenitors to the B cell lineage as well as for the development of B cells...
  81. Inagaki Y, Hayakawa F, Hirano D, Kojima Y, Morishita T, Yasuda T, et al. PAX5 tyrosine phosphorylation by SYK co-operatively functions with its serine phosphorylation to cancel the PAX5-dependent repression of BLIMP1: A mechanism for antigen-triggered plasma cell differentiation. Biochem Biophys Res Commun. 2016;475:176-81 pubmed publisher
    ..Prior to the stimulation of BCR, BLIMP1 is suppressed by PAX5, which is a key transcriptional repressor that maintains B cell identity...
  82. Rai B, Astekar M, Manjunatha B, Sapra G. Diffuse large B cell lymphoma of hard palate: a case report with literature review. J Exp Ther Oncol. 2017;11:101-105 pubmed
    ..Panel of immunohistochemical antibodies were used; which showed positivity for CD45, PAX5, Bcl2, Ki67, CD138 and negativity for CD3, CD10, CD20 and CD30...
  83. Musa Y, Boller S, Puchalska M, Grosschedl R, Mittler G. A comprehensive Proteomic Investigation of Ebf1 Heterozygosity in pro-B lymphocytes utilizing Data Independent Acquisition (DIA). J Proteome Res. 2017;: pubmed publisher
    ..proteins by DIA revealed that, similar to EBF1, the expression of other B-cell lineage regulators, such as TCF3 and Pax5, is also down-regulated in Ebf1 heterozygous cells...
  84. Yuan X, Zhang B, Jiang L, Shen L. [Effect of pax5 gene blocked by RNAi on biological characteristics of B cell malignant lymphoma]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008;16:799-803 pubmed
    ..of B hematological tumor cells such as proliferation, immunological phenotype and apoptosis by silencing pax5. The specific pax5 small hairpin RNA (shRNA) was synthesized by in vitro transcription...
  85. Sullivan L, Atkins K, LeGallo R. PAX immunoreactivity identifies alveolar rhabdomyosarcoma. Am J Surg Pathol. 2009;33:775-80 pubmed publisher
    b>PAX5 is a member of the paired box transcription factors involved in development and its expression has been well characterized among hematopoietic malignancies of B-cell lineage...
  86. Nasr M, Rosenthal N, Syrbu S. Expression profiling of transcription factors in B- or T-acute lymphoblastic leukemia/lymphoma and burkitt lymphoma: usefulness of PAX5 immunostaining as pan-Pre-B-cell marker. Am J Clin Pathol. 2010;133:41-8 pubmed publisher
    ..All 34 (100%) cases of B-ALL expressed PAX5; 32 (94%), BOB.1; 33 (97%), PU.1; 29 (85%), CD79a; 27 (79%), CD22; 2 (6%), CD20; 9 (26%), OCT-2; and 3 (9%), MUM1...
  87. Dimitrova L, Seitz V, Hecht J, Lenze D, Hansen P, Szczepanowski M, et al. PAX5 overexpression is not enough to reestablish the mature B-cell phenotype in classical Hodgkin lymphoma. Leukemia. 2014;28:213-6 pubmed publisher
  88. Fan R. PAX immunoreactivity in poorly differentiated small round cell tumors of childhood. Fetal Pediatr Pathol. 2014;33:244-52 pubmed publisher
    ..We report the immunoreactivity expression patterns of three PAX genes (PAX2, PAX5 and PAX8) in poorly differentiated small round cell tumors of childhood for possible useful diagnostic applications...
  89. Duong L, Crawford R, Scott K, Winkelmann C, Wu G, Szczerba P, et al. Odanacatib, effects of 16-month treatment and discontinuation of therapy on bone mass, turnover and strength in the ovariectomized rabbit model of osteopenia. Bone. 2016;93:86-96 pubmed publisher
    ..While ALN reduced the bone formation marker BSAP, ODN treatment did not affect this marker...
  90. Song J, Zhang H, Wang Z, Xu W, Zhong L, Cao J, et al. The Role of FABP5 in Radiation-Induced Human Skin Fibrosis. Radiat Res. 2017;: pubmed publisher
    ..and corresponding transcriptional factors were identified that associate with the dysregulated proteins, including PAX5, TBX1, CLOCK and AP2D. In particular, FABP5 (2...
  91. Herbeck R, Teodorescu Brinzeu D, Giubelan M, Lazăr E, Dema A, Ioniţă H. B-cell transcription factors Pax-5, Oct-2, BOB.1, Bcl-6, and MUM1 are useful markers for the diagnosis of nodular lymphocyte predominant Hodgkin lymphoma. Rom J Morphol Embryol. 2011;52:69-74 pubmed
    ..In these cases, the transcription factors (TFs) B-cell specific activator protein (BSAP)/Pax-5, octamer binding protein-2 (Oct-2), B-lymphocyte-specific co-activator BOB.1/OBF...
  92. Czapiewski P, Majewska H, Kutzner H, Kazakov D, Renkielska A, Biernat W. TTF-1 and PAX5 Are Frequently Expressed in Combined Merkel Cell Carcinoma. Am J Dermatopathol. 2016;38:513-6 pubmed publisher
    ..However, TTF-1 expression in combined MCC was recently reported. PAX5 is a marker of B-cell origin that is also expressed in most classical MCC cases; however, its expression was not ..