PAX4

Summary

Gene Symbol: PAX4
Description: paired box 4
Alias: KPD, MODY9, paired box protein Pax-4, paired box gene 4, paired domain gene 4
Species: human
Products:     PAX4

Top Publications

  1. Shimajiri Y, Shimabukuro M, Tomoyose T, Yogi H, Komiya I, Takasu N. PAX4 mutation (R121W) as a prodiabetic variant in Okinawans. Biochem Biophys Res Commun. 2003;302:342-4 pubmed
    We previously reported that a missense mutation at codon 121 (CGG(Arg) to TGG(Trp), R121W) of PAX4 may be associated with the onset of type 2 diabetes in Japanese...
  2. Smith S, Watada H, Scheel D, Mrejen C, German M. Autoregulation and maturity onset diabetes of the young transcription factors control the human PAX4 promoter. J Biol Chem. 2000;275:36910-9 pubmed
    During pancreatic development, the paired homeodomain transcription factor PAX4 is required for the differentiation of the insulin-producing beta cells and somatostatin-producing delta cells...
  3. Miyamoto T, Kakizawa T, Ichikawa K, Nishio S, Kajikawa S, Hashizume K. Expression of dominant negative form of PAX4 in human insulinoma. Biochem Biophys Res Commun. 2001;282:34-40 pubmed
    The paired-homeodomain transcription factor PAX4 is expressed in the early pancreas, but is later restricted to beta cells and not expressed in mature islets, suggesting an important role of PAX4 in differentiation and development of ..
  4. Holm P, Rydlander B, Luthman H, Kockum I. Interaction and association analysis of a type 1 diabetes susceptibility locus on chromosome 5q11-q13 and the 7q32 chromosomal region in Scandinavian families. Diabetes. 2004;53:1584-91 pubmed
    ..3. This increase was estimated to correspond to a P value <0.0016 using permutation. The transcription factor PAX4 is located at 7q32 and participates downstream of ISL1 in the transcription factor cascade critical to beta-cell ..
  5. Brun T, Franklin I, St Onge L, Biason Lauber A, Schoenle E, Wollheim C, et al. The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human islets. J Cell Biol. 2004;167:1123-35 pubmed
    The mechanism by which the beta-cell transcription factor Pax4 influences cell function/mass was studied in rat and human islets of Langerhans...
  6. Tokuyama Y, Matsui K, Ishizuka T, Egashira T, Kanatsuka A. The Arg121Trp variant in PAX4 gene is associated with beta-cell dysfunction in Japanese subjects with type 2 diabetes mellitus. Metabolism. 2006;55:213-6 pubmed
    Mutations in PAX4, a transcription factor involved in the beta-cell differentiation, could predispose to the development of type 2 diabetes mellitus...
  7. Plengvidhya N, Kooptiwut S, Songtawee N, Doi A, Furuta H, Nishi M, et al. PAX4 mutations in Thais with maturity onset diabetes of the young. J Clin Endocrinol Metab. 2007;92:2821-6 pubmed
    ..The aim of this study was to investigate whether or not genetic variants in PAX4, a crucial transcription factor in beta-cell development, contribute to MODY in Thais...
  8. Cho Y, Chen C, Hu C, Long J, Ong R, Sim X, et al. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet. 2011;44:67-72 pubmed publisher
    ..loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3...
  9. Shimajiri Y, Sanke T, Furuta H, Hanabusa T, Nakagawa T, Fujitani Y, et al. A missense mutation of Pax4 gene (R121W) is associated with type 2 diabetes in Japanese. Diabetes. 2001;50:2864-9 pubmed
    b>Pax4 is one of the transcription factors that play an important role in the differentiation of islet beta-cells...

More Information

Publications142 found, 100 shown here

  1. Kanatsuka A, Tokuyama Y, Nozaki O, Matsui K, Egashira T. Beta-cell dysfunction in late-onset diabetic subjects carrying homozygous mutation in transcription factors NeuroD1 and Pax4. Metabolism. 2002;51:1161-5 pubmed
    Polymorphisms in beta-cell transcription factor genes, Ala45Thr in the NeuroD1 gene and Arg121Trp in the Pax4 gene, have been reported...
  2. Mauvais Jarvis F, Smith S, Le May C, Leal S, Gautier J, Molokhia M, et al. PAX4 gene variations predispose to ketosis-prone diabetes. Hum Mol Genet. 2004;13:3151-9 pubmed
    ..b>PAX4 is a transcription factor essential for the development of insulin-producing pancreatic beta-cells...
  3. Li Y, Nagai H, Ohno T, Ohashi H, Murohara T, Saito H, et al. Aberrant DNA demethylation in promoter region and aberrant expression of mRNA of PAX4 gene in hematologic malignancies. Leuk Res. 2006;30:1547-53 pubmed
    The PAX4 gene, a member of the paired box (PAX) gene family, is thought to be involved in regulating the fate of beta-cells in the mammalian pancreas...
  4. Mannino G, Sesti G. Individualized therapy for type 2 diabetes: clinical implications of pharmacogenetic data. Mol Diagn Ther. 2012;16:285-302 pubmed publisher
    ..binding protein 2 [IGF2BP2], potassium voltage-gated channel, KQT-like subfamily, member 1 [KCNQ1], paired box 4 [PAX4] and neuronal differentiation 1 [NEUROD1] transcription factors, ataxia telangiectasia mutated [ATM], and serine ..
  5. Bi X, Li F, Liu S, Jin Y, Zhang X, Yang T, et al. ?-3 polyunsaturated fatty acids ameliorate type 1 diabetes and autoimmunity. J Clin Invest. 2017;127:1757-1771 pubmed publisher
    ..islets, and sharply elevated the expression of the ? cell markers pancreatic and duodenal homeobox 1 (Pdx1) and paired box 4 (Pax4). The findings suggest that ?-3 PUFAs could potentially serve as a therapeutic modality for T1D.
  6. Hussain S, Keat S, Gelding S. Ketosis-prone diabetes and SLE co-presenting in an African lady with previous gestational diabetes. Endocrinol Diabetes Metab Case Rep. 2017;2017: pubmed publisher
    ..The challenge of identifying the type of diabetes when clinical features overlap the various diabetes categories is discussed. This is the first report of autoimmune ketosis-prone diabetes (KPD) presenting with new onset of SLE.
  7. Sangan C, Jover R, Heimberg H, Tosh D. In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4α expression. Mol Cell Endocrinol. 2015;399:50-9 pubmed publisher
    ..suppressed glucagon expression, induced key beta cell-specific markers (insulin, C-peptide, glucokinase, GLUT2 and Pax4) and pancreatic polypeptide (PP) and enabled the cells to secrete insulin in a glucose-regulated manner...
  8. Chen M, Hu C, Jia W. Pharmacogenomics of glinides. Pharmacogenomics. 2015;16:45-60 pubmed publisher
    ..In addition, Type 2 diabetes mellitus susceptibility genes, such as KCNQ1, PAX4 and BETA2, also influence the efficacy of glinides...
  9. Kordowich S, Collombat P, Mansouri A, Serup P. Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage. BMC Dev Biol. 2011;11:52 pubmed publisher
    ..Our data indicate that Nkx2.2 acts by reinforcing the transcriptional networks initiated by Pax4 and Arx in early committed beta- and alpha-cell, respectively...
  10. Ang S, Tan C, Wang L, Dorajoo R, Fong J, Kon W, et al. PAX4 R192H is associated with younger onset of Type 2 diabetes in East Asians in Singapore. J Diabetes Complications. 2019;33:53-58 pubmed publisher
    ..The association of PAX4 R192H (rs2233580) variation with YT2D was inconsistent partly because of its Asian-specificity and under-..
  11. Qu S, Dai C, Yang F, Huang T, Hao Z, Tang Q, et al. Cefquinome-Loaded Microsphere Formulations in Protection against Pneumonia with Klebsiella pneumonia Infection and Inflammatory Response in Rats. Pharm Res. 2019;36:74 pubmed publisher
    ..divided into control group (sham operated without infection and drug treatment), Klebsiella pneumonia model group (KPD + Saline), CEQ-PLGA-MS and CEQ-INJ therapy groups (KPD + CEQ-PLGA-MS and KPD + INJ, respectively)...
  12. Maedler K, Schumann D, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, et al. Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets. Diabetes. 2006;55:2713-22 pubmed
    ..A similarly bimodal induction of FLIP, pancreatic duodenal homeobox (PDX)-1, and Pax4 mRNA expression, as well as glucose-stimulated insulin secretion, was observed...
  13. Ashapkin V, Linkova N, Khavinson V, Vanyushin B. Epigenetic mechanisms of peptidergic regulation of gene expression during aging of human cells. Biochemistry (Mosc). 2015;80:310-22 pubmed publisher
    ..The methylation patterns of the PAX4 gene in pancreatic cells as well as those of the FOXA1, SCGB3A2, and SFTPA1 genes in bronchial cells do not change ..
  14. Lontchi Yimagou E, Legoff J, Nguewa J, Boudou P, Balti E, Noubiap J, et al. Human herpesvirus 8 infection DNA positivity is associated with low insulin secretion: A case-control study in a sub-Saharan African population with diabetes. J Diabetes. 2018;10:866-873 pubmed publisher
    ..diabetes were enrolled consecutively: 124 with type 2 diabetes mellitus (T2DM) and 49 with ketosis-prone diabetes (KPD) admitted in hyperglycemic crisis...
  15. Lima M, Docherty H, Chen Y, Docherty K. Efficient differentiation of AR42J cells towards insulin-producing cells using pancreatic transcription factors in combination with growth factors. Mol Cell Endocrinol. 2012;358:69-80 pubmed publisher
    ..were used to induce exogenous expression of the pancreatic transcription factors (TFs) Pdx1, MafA, Ngn3 and Pax4. Individually Pdx1, MafA and Pax4 had no effect on the expression of endocrine markers, whilst adeno-Ngn3 on its ..
  16. Jin C, Li W, Xu F, Geng Z, He Z, Su J, et al. Conversion of immortal liver progenitor cells into pancreatic endocrine progenitor cells by persistent expression of Pdx-1. J Cell Biochem. 2008;104:224-36 pubmed
    ..2, Nkx6.1, Pax4, Pax6, Isl1, MafA and endogenous Pdx-1, but did not secrete insulin...
  17. Hong J, Li S, Wang X, Mei C, Zan L. Study of expression analysis of SIRT4 and the coordinate regulation of bovine adipocyte differentiation by SIRT4 and its transcription factors. Biosci Rep. 2018;38: pubmed publisher
    ..protein β (CEBPβ), homeobox A5 (HOXA5), interferon regulatory factor 4 (IRF4), paired box 4 (PAX4), and cAMP responsive element-binding protein 1 (CREB1) by using Electrophoretic mobility shift assay (EMSA) and ..
  18. Lima M, Muir K, Docherty H, Drummond R, McGowan N, Forbes S, et al. Suppression of epithelial-to-mesenchymal transitioning enhances ex vivo reprogramming of human exocrine pancreatic tissue toward functional insulin-producing β-like cells. Diabetes. 2013;62:2821-33 pubmed publisher
    ..was developed whereby transduction of these mesenchymal cells with adenoviruses containing Pdx1, Ngn3, MafA, and Pax4 generated a population of cells that were enriched in glucagon-secreting α-like cells...
  19. Mulukutla S, Acevedo Calado M, Hampe C, Pietropaolo M, Balasubramanyam A. Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of "A+" Subtypes of Ketosis-Prone Diabetes. Diabetes Care. 2018;41:2637-2640 pubmed publisher
    ..Conventional assays target the intracellular domain of IA-2. Among patients with ketosis-prone diabetes (KPD), characterized by presentation with diabetic ketoacidosis (DKA), >60% of adults lack three classic islet ..
  20. Lebovitz H, Banerji M. Ketosis-Prone Diabetes (Flatbush Diabetes): an Emerging Worldwide Clinically Important Entity. Curr Diab Rep. 2018;18:120 pubmed publisher
    ..Little data are available on the magnitude of KPD in the different susceptible populations. It is relatively common in black populations...
  21. Lee G, Jang H, Kim Y, Choe S, Kong J, Hwang I, et al. SREBP1c-PAX4 Axis Mediates Pancreatic β-Cell Compensatory Responses Upon Metabolic Stress. Diabetes. 2019;68:81-94 pubmed publisher
    ..promoted the expression of cell cycle genes and stimulated β-cell proliferation through its novel target gene, PAX4 Compared with SREBP1c+/+ mice, SREBP1c-/- mice showed glucose intolerance ..
  22. Mazur M, Winkler M, Ganic E, Colberg J, Johansson J, Bennet H, et al. Microphthalmia transcription factor regulates pancreatic β-cell function. Diabetes. 2013;62:2834-42 pubmed publisher
    ..of genes critical for maintaining glucose homeostasis (insulin and Glut2) and β-cell formation and function (Pax4 and Pax6) is significantly upregulated in Mitf mutant islets...
  23. Brooks Worrell B, Iyer D, Coraza I, Hampe C, Nalini R, Ozer K, et al. Islet-specific T-cell responses and proinflammatory monocytes define subtypes of autoantibody-negative ketosis-prone diabetes. Diabetes Care. 2013;36:4098-103 pubmed publisher
    Ketosis-prone diabetes (KPD) is characterized by diabetic ketoacidosis (DKA) in patients lacking typical features of type 1 diabetes...
  24. Balaji S, Zhou Y, Ganguly A, Opara E, Soker S. The combined effect of PDX1, epidermal growth factor and poly-L-ornithine on human amnion epithelial cells' differentiation. BMC Dev Biol. 2016;16:8 pubmed publisher
    ..Other markers of various stages of pancreatic differentiation such as NKX6.1, SOX17, RFX6, FOXA2, CFTR, NEUROD1, PAX4 and PPY were also expressed upon Pdx1 transduction...
  25. Dugnani E, Sordi V, Pellegrini S, Chimienti R, Marzinotto I, Pasquale V, et al. Gene expression analysis of embryonic pancreas development master regulators and terminal cell fate markers in resected pancreatic cancer: A correlation with clinical outcome. Pancreatology. 2018;18:945-953 pubmed publisher
    ..2, NKX6.1, PAX4, PAX6, PDX1 and PTF1α) or associated with terminally committed pancreatic cells (CHGA, CHGB, GAD2, GCG, HNF6α, ..
  26. Zhou S, Li F, Li Y, Zhang C, Sun Y, Zhang G. [Knockdown of LSD1 promotes differentiation of human induced pluripotent stem cells into insulin-producing cells in vitro]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2018;34:718-724 pubmed
    ..Real-time quantitative PCR was used to detect the mRNA levels of LSD1, OCT4, SOX17, FOXA2, PDX1, PAX4, PAX6, HNF6, TCF1, NKX6.1, GLUT2, GK, insulin and MAFA...
  27. Ferrari P, Weimar W, Johnson R, Lim W, Tinckam K. Kidney paired donation: principles, protocols and programs. Nephrol Dial Transplant. 2015;30:1276-85 pubmed publisher
    ..These include desensitization in antibody-incompatible transplants and kidney paired donation (KPD) programs...
  28. Şuşman S, Rus Ciucă D, Soriţău O, Ciortea R, Gîrlovanu M, Mihu D, et al. Human placenta - stem cell source for obtaining pancreatic progenitors. Rom J Morphol Embryol. 2015;56:505-10 pubmed
    ..differentiation expressed transcription factors, which are characteristic for pancreatic progenitors (Pdx1 and PAX4). During the experiment, the cells modified their morphology by forming islet-like clusters...
  29. Lorenzo P, Juárez Vicente F, Cobo Vuilleumier N, Garcia Dominguez M, Gauthier B. The Diabetes-Linked Transcription Factor PAX4: From Gene to Functional Consequences. Genes (Basel). 2017;8: pubmed publisher
    Paired box 4 (PAX4) is a key factor in the generation of insulin producing ?-cells during embryonic development...
  30. Li Y, Zheng J, Shen Y, Li W, Liu M, Wang J, et al. Comparative Study of Liraglutide and Insulin Glargine on Glycemic Control and Pancreatic β-Cell Function in db/db Mice. Med Sci Monit. 2018;24:3293-3300 pubmed publisher
    ..transcription polymerase chain reaction (RT-PCR), and pancreatic and duodenal homeobox 1 (Pdx1), paired box 4 (Pax4), and paired box 6 (Pax6) mRNA expression were measured...
  31. Kwak S, Jung C, Ahn C, Park J, Chae J, Jung H, et al. Clinical whole exome sequencing in early onset diabetes patients. Diabetes Res Clin Pract. 2016;122:71-77 pubmed publisher
    ..Although four rare non-silent variants in MODY genes (p.Arg183Cys in PAX4, p.Val139Ile and p.Pro740fs in CEL, and p...
  32. Gupta R, Ramachandran R, Gangadhara P, Anoop S, Singh S, Satyaraddi A, et al. Clinical characteristics, beta-cell dysfunction and treatment outcomes in patients with A-?+ Ketosis-Prone Diabetes (KPD): The first identified cohort amongst Asian Indians. J Diabetes Complications. 2017;31:1401-1407 pubmed publisher
    Ketosis-prone diabetes (KPD), an atypical form of diabetes, has emerged as a heterogeneous syndrome in multiple ethnic groups...
  33. Yuan Q, Ma C, Yu H, Bian X. A Key Pre-Distribution Scheme Based on µ-PBIBD for Enhancing Resilience in Wireless Sensor Networks. Sensors (Basel). 2018;18: pubmed publisher
    Many key pre-distribution (KPD) schemes based on combinatorial design were proposed for secure communication of wireless sensor networks (WSNs)...
  34. Nalini R, Ozer K, Maldonado M, Patel S, Hampe C, Guthikonda A, et al. Presence or absence of a known diabetic ketoacidosis precipitant defines distinct syndromes of "A-?+" ketosis-prone diabetes based on long-term ?-cell function, human leukocyte antigen class II alleles, and sex predilection. Metabolism. 2010;59:1448-55 pubmed publisher
    Ketosis-prone diabetes (KPD) is heterogeneous...
  35. Yorsin S, Kanokwiroon K, Radenahmad N, Jansakul C. Effects of Kaempferia parviflora rhizomes dichloromethane extract on vascular functions in middle-aged male rat. J Ethnopharmacol. 2014;156:162-74 pubmed publisher
    ..whether a 6 weeks oral administration of a dichloromethane extract of fresh rhizomes of Kaempferia parviflora (KPD) had any effects on vascular functions, on the accumulation of lipid, as well as on any signs of gross organ ..
  36. Baines L, Dulku H, Jindal R, Papalois V. Risk Taking and Decision Making in Kidney Paired Donation: A Qualitative Study by Semistructured Interviews. Transplant Proc. 2018;50:1227-1235 pubmed publisher
    Despite excellent outcomes of kidney paired donation (KPD), little is known about how a patient's frame (apply cognitive bias) or weight (attribute value) and concerns relating to risk, justice, and equity affect his or her decision-..
  37. Maleńczyk K, Szodorai E, Schnell R, Lubec G, Szabo G, Hokfelt T, et al. Secretagogin protects Pdx1 from proteasomal degradation to control a transcriptional program required for β cell specification. Mol Metab. 2018;14:108-120 pubmed publisher
    ..Secretagogin promoter activity was tested in response to genetically manipulating Pax6 and Pax4 expression...
  38. Howson J, Walker N, Smyth D, Todd J. Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families. Genes Immun. 2009;10 Suppl 1:S74-84 pubmed publisher
    ..polymorphisms (SNPs) have been genotyped in 19 candidate genes (INS, PTPN22, IL2RA, CTLA4, IFIH1, SUMO4, VDR, PAX4, OAS1, IRS1, IL4, IL4R, IL13, IL12B, CEACAM21, CAPSL, Q7Z4c4(5Q), FOXP3, EFHB) in 2300 affected sib-pair families ..
  39. Bai H, Liu H, Suyalatu S, Guo X, Chu S, Chen Y, et al. Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China. J Diabetes Res. 2015;2015:613236 pubmed publisher
    ..rs6723108 (TMEM163), rs163182 and rs2237897 (KCNQ1), rs1387153 (MTNR1B), rs243021 (BCL11A), and rs10229583 (PAX4) in our sample...
  40. Lizio M, Ishizu Y, Itoh M, Lassmann T, Hasegawa A, Kubosaki A, et al. Mapping Mammalian Cell-type-specific Transcriptional Regulatory Networks Using KD-CAGE and ChIP-seq Data in the TC-YIK Cell Line. Front Genet. 2015;6:331 pubmed publisher
    ..only), NEUROD1 directly transcriptionally activates the pancreatic TFs HSF4, INSM1, MLXIPL, MYT1, NKX6-3, ONECUT2, PAX4, PROX1, RFX6, ST18, DACH1, and SHOX2, while LMX1A directly transcriptionally activates DACH1, SHOX2, PAX6, and PDX1...
  41. Choukem S, Sobngwi E, Garnier J, Letellier S, Mauvais Jarvis F, Calvo F, et al. Hyperglycaemia per se does not affect erythrocyte glucose-6-phosphate dehydrogenase activity in ketosis-prone diabetes. Diabetes Metab. 2015;41:326-30 pubmed publisher
    Previously, we described patients with ketosis-prone type 2 diabetes (KPD) and glucose-6-phosphate dehydrogenase (G6PD) deficiency, but no mutation of the G6PD gene...
  42. Wang Y, Zhang J, Zhao Y, Wang S, Zhang J, Han Q, et al. COL4A3 Gene Variants and Diabetic Kidney Disease in MODY. Clin J Am Soc Nephrol. 2018;13:1162-1171 pubmed publisher
    ..HNF1B-MODY, CEL-MODY, PAX4-MODY, and WFS1-MODY were diagnosed among nine families...
  43. Salisbury R, Han B, Jennings R, Berry A, Stevens A, Mohamed Z, et al. Altered Phenotype of β-Cells and Other Pancreatic Cell Lineages in Patients With Diffuse Congenital Hyperinsulinism in Infancy Caused by Mutations in the ATP-Sensitive K-Channel. Diabetes. 2015;64:3182-8 pubmed publisher
    ..Islets were disorganized in CHI-D compared with controls. PAX4 and ARX expression was decreased. A tendency toward increased NKX2...
  44. Lima M, Muir K, Docherty H, McGowan N, Forbes S, Heremans Y, et al. Generation of Functional Beta-Like Cells from Human Exocrine Pancreas. PLoS ONE. 2016;11:e0156204 pubmed publisher
    ..can be efficiently reprogrammed to islet-like cells using a cocktail of transcription factors: Pdx1, Ngn3, MafA and Pax4 in combination with growth factors...
  45. Porto Fett A, Campano S, Shoyer B, Israeli D, Oser A, Luchansky J. Comparative Efficacy of Potassium Levulinate with and without Potassium Diacetate and Potassium Propionate versus Potassium Lactate and Sodium Diacetate for Control of Listeria monocytogenes on Commercially Prepared Uncured Turkey Breast. J Food Prot. 2015;78:927-33 pubmed publisher
    ..0, 1.0, 1.5, and 2.0%) with and without a blend of potassium propionate (0.1%) and potassium diacetate (0.1%) (KPD) versus a blend of potassium lactate (1.8%) and sodium diacetate (0...
  46. Gage B, Asadi A, Baker R, Webber T, Wang R, Itoh M, et al. The Role of ARX in Human Pancreatic Endocrine Specification. PLoS ONE. 2015;10:e0144100 pubmed publisher
    ..Differentiated ARX knockout cells upregulated PAX4, NKX2.2, ISL1, HHEX, PCSK1, PCSK2 expression while downregulating PAX6 and IRX2...
  47. Fujiwara M, Kubota T, Wang W, Ohata Y, Miura K, Kitaoka T, et al. Successful induction of sclerostin in human-derived fibroblasts by 4 transcription factors and its regulation by parathyroid hormone, hypoxia, and prostaglandin E2. Bone. 2016;85:91-8 pubmed publisher
    ..SOST expression was sought by their viral transduction into fibroblasts, and a combination of four TFs: ATF3, KLF4, PAX4, and SP7, was identified as the most effective inducer of SOST expression...
  48. Beaver L, Nkrumah Elie Y, Truong L, Barton C, Knecht A, Gonnerman G, et al. Adverse effects of parental zinc deficiency on metal homeostasis and embryonic development in a zebrafish model. J Nutr Biochem. 2017;43:78-87 pubmed publisher
    ..associated with decreased expression of genes related to diabetes and pancreatic development in the embryo (Insa, Pax4, Pdx1)...
  49. Ripoche D, Charbord J, Hennino A, Teinturier R, Bonnavion R, Jaafar R, et al. ActivinB Is Induced in Insulinoma To Promote Tumor Plasticity through a β-Cell-Induced Dedifferentiation. Mol Cell Biol. 2015;36:756-64 pubmed publisher
    ..Our data further identify Pax4 as a previously unknown activinB target and potent contributor to the observed β-cell dedifferentiation...
  50. Kwak S, Chae J, Lee S, Choi S, Koo B, Yoon J, et al. Nonsynonymous Variants in PAX4 and GLP1R Are Associated With Type 2 Diabetes in an East Asian Population. Diabetes. 2018;67:1892-1902 pubmed publisher
    ..A total of 728,838 variants were identified by whole-exome sequencing. Among nonsynonymous variants, PAX4 Arg192His increased risk of T2D and GLP1R Arg131Gln decreased risk of T2D in genome-wide significance (..
  51. Fang A, Zhang Y, Li M, Guo H, Yu X, Li F, et al. Effects of DNA methylation and histone modification on differentiation-associated gene expression in ES, NIH3T3, and NIT-1. J Huazhong Univ Sci Technolog Med Sci. 2011;31:10-16 pubmed publisher
    ..of epigenetic modification on the differentiation of islet cells and the expression of associated genes (Pdx-1, Pax4, MafA, and Nkx6.1, etc) were investigated...
  52. Hussein H, Ibrahim F, Sobngwi E, Gautier J, Boudou P. Zinc transporter 8 autoantibodies assessment in daily practice. Clin Biochem. 2017;50:94-96 pubmed publisher
    ..had Latent Autoimmune Diabetes of Adults (LADA), 38 were type 2 diabetic (T2D) and 56 had ketosis-prone diabetes (KPD). 82 patients were newly diagnosed cases...
  53. Shaer A, Azarpira N, Vahdati A, Karimi M, Shariati M. miR-375 induces human decidua basalis-derived stromal cells to become insulin-producing cells. Cell Mol Biol Lett. 2014;19:483-99 pubmed publisher
    ..Total RNA was extracted 4 and 6 days after transfection. The expressions of insulin, NGN3, GLUT2, PAX4, PAX6, KIR6.2, NKX6.1, PDX1, and glucagon genes were evaluated using real-time qPCR...
  54. Chakraborty C, Bandyopadhyay S, Doss C, Agoramoorthy G. Exploring the Genomic Roadmap and Molecular Phylogenetics Associated with MODY Cascades Using Computational Biology. Cell Biochem Biophys. 2015;71:1491-502 pubmed publisher
    ..Protein-protein network design shows that HNF1A, HNF1B, HNF4A, NEUROD1, PDX1, PAX4, INS, and GCK are strongly connected, and the co-expression analyses between MODY genes also show distinct ..
  55. Lorenzo P, Cobo Vuilleumier N, Gauthier B. Therapeutic potential of pancreatic PAX4-regulated pathways in treating diabetes mellitus. Curr Opin Pharmacol. 2018;43:1-10 pubmed publisher
    ..One of these factors is the transcription factor PAX4, required for β-cell formation during embryonic development and implicated in adult β-cell adaptation under ..
  56. Rocco C, Seshadri B, Adamo P, Bolan N, Mbene K, Naidu R. Impact of waste-derived organic and inorganic amendments on the mobility and bioavailability of arsenic and cadmium in alkaline and acid soils. Environ Sci Pollut Res Int. 2018;25:25896-25905 pubmed publisher
    ..in two Australian soils with different pH and texture: Mount Gambier (MGB)-alkaline sandy clay loam and Kapuda (KPD)-acid loamy sand...
  57. Balti E, Ngo Nemb M, Lontchi Yimagou E, Atogho Tiedeu B, Effoe V, Akwo E, et al. Association of HLA class II markers with autoantibody-negative ketosis-prone atypical diabetes compared to type 2 diabetes in a population of sub-Saharan African patients. Diabetes Res Clin Pract. 2015;107:31-6 pubmed publisher
    ..and DQB1 alleles, haplotypes and genotypes with unprovoked antibody-negative ketosis-prone atypical diabetes (A(-) KPD) in comparison to type 2 diabetes (T2D)...
  58. Bose B, Sudheer P. In Vitro Differentiation of Pluripotent Stem Cells into Functional β Islets Under 2D and 3D Culture Conditions and In Vivo Preclinical Validation of 3D Islets. Methods Mol Biol. 2016;1341:257-84 pubmed publisher
    ..Eventually with the discovery of hierarchy of β cell transcription factors like Pdx1, Pax4, and Nkx2...
  59. Fernández Gómez C, Bayona J, Díez S. Diffusive gradients in thin films for predicting methylmercury bioavailability in freshwaters after photodegradation. Chemosphere. 2015;131:184-91 pubmed publisher
    ..First order photodegradation rate constants (kpd) of bioavailable MeHg determined in five different types of waters with different amount of dissolved organic ..
  60. Habib A, Richards P, Cairns L, Rogers G, Bannon C, Parker H, et al. Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry. Endocrinology. 2012;153:3054-65 pubmed publisher
    ..Etv1, Prox1, and Pax4 were significantly enriched in L-cells vs. K cells by quantitative RT-PCR...
  61. Gaba R, Gambhire D, Uy N, Gonzalez E, Iyer D, Hampe C, et al. Factors associated with early relapse to insulin dependence in unprovoked A-β+ ketosis-prone diabetes. J Diabetes Complications. 2015;29:918-22 pubmed publisher
    Unprovoked "A-β+" Ketosis-Prone Diabetes (KPD), a unique diabetic syndrome of adult-onset, obesity and proneness to ketoacidosis, is associated with rapid recovery of β cell function and insulin-independence...
  62. Tian X, Zhang X. A Single Nucleotide Polymorphism (rs1056629) in 3'-UTR of MMP-9 is Responsible for a Decreased Risk of Metastatic Osteosarcoma by Compromising its Interaction with microRNA-491-5p. Cell Physiol Biochem. 2016;38:1415-24 pubmed publisher
    ..Furthermore, 10 OS cell lines (OSA, MG-63, Saos-2, U2OS, SARG, KPD, OHS, HAL, ZK-58, and MHM) were genotyped for the rs1056629 polymorphism, and MG-63 (AA) and OSA (AC) were ..
  63. Kayali A, Lopez A, Hao E, Hinton A, Hayek A, King C. The SDF-1?/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells. PLoS ONE. 2012;7:e38721 pubmed publisher
    ..1, Ngn3 and PAX4. However, a strong inhibition of ? cell genesis was observed when in vitro AMD3100 treatment of ICCs was followed ..
  64. Zhang Y, Fava G, Wang H, Mauvais Jarvis F, Fonseca V, Wu H. PAX4 Gene Transfer Induces α-to-β Cell Phenotypic Conversion and Confers Therapeutic Benefits for Diabetes Treatment. Mol Ther. 2016;24:251-260 pubmed publisher
    The transcription factor Pax4 plays a critical role in the determination of α- versus β-cell lineage during endocrine pancreas development...
  65. Teichenne J, Morró M, Casellas A, Jimenez V, Téllez N, Léger A, et al. Identification of miRNAs Involved in Reprogramming Acinar Cells into Insulin Producing Cells. PLoS ONE. 2015;10:e0145116 pubmed publisher
    ..than AR42J cells, which was demonstrated by a strong activation of β cell markers (Ins1, Ins2, IAPP, NeuroD1 and Pax4)...
  66. Anderson R, Ashlagi I, Gamarnik D, Roth A. Finding long chains in kidney exchange using the traveling salesman problem. Proc Natl Acad Sci U S A. 2015;112:663-8 pubmed publisher
    ..To address this shortage, kidney paired donation (KPD) programs allow patients with living but biologically incompatible donors to exchange donors through cycles or ..
  67. Cnop M, Abdulkarim B, Bottu G, Cunha D, Igoillo Esteve M, Masini M, et al. RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate. Diabetes. 2014;63:1978-93 pubmed publisher
    ..Palmitate inhibited transcription factors controlling β-cell phenotype, including PAX4 and GATA6. Fifty-nine T2D candidate genes were expressed in human islets, and 11 were modified by palmitate...
  68. Chen L, Zhang J, Zhang Z, Chu Y, Song B, Cai W. Pax4 Expression does not Transduce Pancreatic Alpha Cells to Beta Cells. Cell Physiol Biochem. 2015;36:1735-42 pubmed
    ..Thus, generation of beta cells from other sources is substantially required. Pax4 has been shown to induce reprograming of alpha cells into beta cells during embryogenesis...
  69. Kim U, Yoon J, Li H, Kang J, Ji H, Park K, et al. Pterocarpan-enriched soy leaf extract ameliorates insulin sensitivity and pancreatic β-cell proliferation in type 2 diabetic mice. Molecules. 2014;19:18493-510 pubmed publisher
    ..EASL group up-regulated neurogenin 3 (Ngn3), paired box 4 (Pax4), and v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA), which are markers of pancreatic cell ..
  70. Ang S, Lim S, Tan C, Fong J, Kon W, Lian J, et al. A preliminary study to evaluate the strategy of combining clinical criteria and next generation sequencing (NGS) for the identification of monogenic diabetes among multi-ethnic Asians. Diabetes Res Clin Pract. 2016;119:13-22 pubmed publisher
    ..had another HNF4A variant), 1 in HNF4A, 2 in mt3243A>G and 1 each in GCK, KCNJ11 (novel), ABCC8 (novel) and PAX4 (novel). Performance of the MODY calculator was: sensitivity 0.769, specificity 0...
  71. Ashby V, Leichtman A, Rees M, Song P, Bray M, Wang W, et al. A Kidney Graft Survival Calculator that Accounts for Mismatches in Age, Sex, HLA, and Body Size. Clin J Am Soc Nephrol. 2017;12:1148-1160 pubmed publisher
    Outcomes for transplants from living unrelated donors are of particular interest in kidney paired donation (KPD) programs where exchanges can be arranged between incompatible donor-recipient pairs or chains created from nondirected/..
  72. Lima M, Docherty H, Chen Y, Vallier L, Docherty K. Pancreatic transcription factors containing protein transduction domains drive mouse embryonic stem cells towards endocrine pancreas. PLoS ONE. 2012;7:e36481 pubmed publisher
    ..by the combination of Pdx1 and TAT-MafA in a second phase, up-regulation of insulin 1, insulin 2, Pdx1, Glut2, Pax4 and Nkx6.1 was observed...
  73. Napolitano T, Avolio F, Courtney M, Vieira A, Druelle N, Ben Othman N, et al. Pax4 acts as a key player in pancreas development and plasticity. Semin Cell Dev Biol. 2015;44:107-14 pubmed publisher
    ..Among the direct targets of Neurog3, Pax4 appears as one of the key regulators of β-cell specification...
  74. Friedman Mazursky O, Elkon R, Efrat S. Redifferentiation of expanded human islet β cells by inhibition of ARX. Sci Rep. 2016;6:20698 pubmed publisher
    ..Specifically, RC treatment induces the transcription factors PAX4 and ARX, which play key roles in directing pancreas endocrine progenitor cells into the β/δ or α/PP ..
  75. Anık A, Çatlı G, Abacı A, Sarı E, Yeşilkaya E, Korkmaz H, et al. Molecular diagnosis of maturity-onset diabetes of the young (MODY) in Turkish children by using targeted next-generation sequencing. J Pediatr Endocrinol Metab. 2015;28:1265-71 pubmed publisher
    ..Molecular analyses of GCK, HNF1A, HNF4A, HNF1B, PDX1, NEUROD1, KLF11, CEL, PAX4, INS, and BLK genes were performed on genomic DNA by using next-generation sequencing...
  76. Xu Y, Wang Y, Song Y, Deng J, Chen M, Ouyang H, et al. Generation and Phenotype Identification of PAX4 Gene Knockout Rabbit by CRISPR/Cas9 System. G3 (Bethesda). 2018;8:2833-2840 pubmed publisher
    ..which is associated with many different types of DM, including T1DM, T2DM, maturity onset diabetes of the young 9 (MODY9) and ketosis prone diabetes...
  77. Volodin A, Kosti I, Goldberg A, Cohen S. Myofibril breakdown during atrophy is a delayed response requiring the transcription factor PAX4 and desmin depolymerization. Proc Natl Acad Sci U S A. 2017;114:E1375-E1384 pubmed publisher
    ..Trim32, which leads to the later myofibril breakdown by enzymes, whose expression is increased by the paired box 4 (PAX4) transcription factor...
  78. Sharma A, Rani R. Do we really need to differentiate mesenchymal stem cells into insulin-producing cells for attenuation of the autoimmune responses in type 1 diabetes: immunoprophylactic effects of precursors to insulin-producing cells. Stem Cell Res Ther. 2017;8:167 pubmed publisher
    ..high-glucose media for 11 to 13 passages expressed genes of the pancreatic lineage such as PDX1, beta2, neurogenin, PAX4, Insulin, and glucagon...
  79. Mellado Gil J, Fuente Martín E, Lorenzo P, Cobo Vuilleumier N, López Noriega L, Martín Montalvo A, et al. The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity. Cell Death Dis. 2018;9:279 pubmed publisher
    ..rat INS-1E cell line resulted in decreased expression levels of its neuronal target gene NeuroD whereas Rest and Pax4 were increased. Chromatin immunoprecipitation confirmed the interaction of HMG20A with the Pax4 gene promoter...
  80. Lorenzo P, Fuente Martín E, Brun T, Cobo Vuilleumier N, Jiménez Moreno C, G Herrera Gomez I, et al. PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic Islet. Sci Rep. 2015;5:15672 pubmed publisher
    b>PAX4 is a key regulator of pancreatic islet development whilst in adult acute overexpression protects β-cells against stress-induced apoptosis and stimulates proliferation...
  81. Nguewa J, Lontchi Yimagou E, Agbelika F, AitDjoudi M, Boudou P, Choukem S, et al. Relationship between HHV8 infection markers and insulin sensitivity in ketosis-prone diabetes. Diabetes Metab. 2017;43:79-82 pubmed publisher
    ..the presence of the virus is associated with insulin resistance in patients with ketosis-prone type 2 diabetes (KPD), as reported with other viruses...
  82. Pham T, Lee J, Melcher M. Kidney paired exchange and desensitization: Strategies to transplant the difficult to match kidney patients with living donors. Transplant Rev (Orlando). 2017;31:29-34 pubmed publisher
    ..To overcome these barriers to transplant, strategies such as kidney paired donation (KPD) and desensitization have been developed...
  83. Mellado Gil J, Jiménez Moreno C, Martin Montalvo A, Alvarez Mercado A, Fuente Martín E, Cobo Vuilleumier N, et al. PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus. Diabetologia. 2016;59:755-65 pubmed publisher
    ..therapeutic potential of such a target, the islet-enriched and diabetes-linked transcription factor paired box 4 (PAX4), to restrain experimental autoimmune diabetes (EAD) in the RIP-B7...
  84. Oh D, Kang E, Yu S, Chun K, Huh W, Jang H, et al. Case Report of Kidney Paired Donation (KPD) with Desensitization: the Strategy and Experience of 3-Way KPD in Samsung Medical Center. J Korean Med Sci. 2018;33:e39 pubmed publisher
    ..These include kidney paired donation (KPD) programs and desensitization in incompatible transplantations...
  85. Alnawaiseh M, Rosentreter A, Eter N, Zumhagen L. Changes in Corneal Refractive Power for Patients With Fuchs Endothelial Dystrophy After DMEK. Cornea. 2016;35:1073-7 pubmed publisher
    ..We also analyzed changes in the keratometric power deviation (KPD) and pachymetry. Changes in the SimK in the central cornea were minimal and not significant (SimK 3: before = 43...
  86. Jiang F, Li K, Archer M, Mehta M, Jamieson E, Charles A, et al. Differentiation of Islet Progenitors Regulated by Nicotinamide into Transcriptome-Verified β Cells That Ameliorate Diabetes. Stem Cells. 2017;35:1341-1354 pubmed publisher
    ..enrichment analysis showed that during differentiation, numerous IPC transcription factor genes, including Ngn3, Pax4, Fev, and Mycl1, were all down regulated...
  87. Sheets T, Park K, Park C, Swift S, Powell A, Donovan D, et al. Targeted Mutation of NGN3 Gene Disrupts Pancreatic Endocrine Cell Development in Pigs. Sci Rep. 2018;8:3582 pubmed publisher
    ..biallelic knockout (Δ2/Δ2), which showed a loss of putative NGN3-downstream target genes: NEUROD1 and PAX4, as well as insulin, glucagon, somatostatin and pancreatic polypeptide-Y...
  88. Kemp D, Lin J, Habener J. Regulation of Pax4 paired homeodomain gene by neuron-restrictive silencer factor. J Biol Chem. 2003;278:35057-62 pubmed
    ..genes involved in pancreas development that also harbor NRSE-like motifs, including pdx-1, Beta2/NeuroD, and pax4. The paired homeodomain transcription factor Pax4 is implicated in the differentiation of the insulin-producing ..
  89. Biason Lauber A, Boehm B, Lang Muritano M, Gauthier B, Brun T, Wollheim C, et al. Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia. 2005;48:900-5 pubmed
    ..To study the role of islet cell regeneration in the pathogenesis of type 1 diabetes, we focused on PAX4, a paired homeodomain transcriptional repressor that is involved in islet cell growth...
  90. Dusatkova P, Vesela K, Pruhova S, Lebl J, Cinek O. Lack of PAX4 mutations in 53 Czech MODYX families. Diabet Med. 2010;27:1459-60 pubmed publisher
  91. Ma R, Hu C, Tam C, Zhang R, Kwan P, Leung T, et al. Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4. Diabetologia. 2013;56:1291-305 pubmed publisher
    ..Our study identifies rs10229583 near PAX4 as a novel locus for type 2 diabetes in Chinese and other populations and provides new insights into the ..
  92. Ashlagi I, Bingaman A, Burq M, Manshadi V, Gamarnik D, Murphey C, et al. The effect of match-run frequencies on the number of transplants and waiting times in kidney exchange. Am J Transplant. 2017;: pubmed publisher
    Numerous kidney exchange (kidney paired donor (KPD)) registries in the U.S have gradually shifted to high frequency match-runs, raising the question of whether this harms the number of transplants...