Pax2

Summary

Gene Symbol: Pax2
Description: paired box 2
Alias: FSGS7, PAPRS, paired box protein Pax-2, paired box homeotic gene 2
Species: human
Products:     Pax2

Top Publications

  1. Ozcan A, Zhai J, Hamilton C, Shen S, Ro J, Krishnan B, et al. PAX-2 in the diagnosis of primary renal tumors: immunohistochemical comparison with renal cell carcinoma marker antigen and kidney-specific cadherin. Am J Clin Pathol. 2009;131:393-404 pubmed publisher
    ..PAX-2 seems to have a significant role in renal neogenesis and may represent a novel therapeutic target. ..
  2. Dahl E, Koseki H, Balling R. Pax genes and organogenesis. Bioessays. 1997;19:755-65 pubmed
    ..diseases such as Waardenburg syndrome (PAX3), Aniridia (PAX6), Peter's anomaly (PAX6), renal coloboma syndrome (PAX2) or spontaneous mouse mutants (undulated (Pax1), Splotch (Pax3), Small eye (Pax6), Pax2(1)Neu), which all show ..
  3. Tavassoli K, Rüger W, Horst J. Alternative splicing in PAX2 generates a new reading frame and an extended conserved coding region at the carboxy terminus. Hum Genet. 1997;101:371-5 pubmed
    b>PAX2 is a member of the PAX multigene family encoding transcription factors active in specific tissues during embryogenesis...
  4. Sanyanusin P, Schimmenti L, McNoe L, Ward T, Pierpont M, Sullivan M, et al. Mutation of the PAX2 gene in a family with optic nerve colobomas, renal anomalies and vesicoureteral reflux. Nat Genet. 1995;9:358-64 pubmed
    Paired box (PAX) genes play a critical role in human development and disease. The PAX2 gene is expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system...
  5. Dehbi M, Ghahremani M, Lechner M, Dressler G, Pelletier J. The paired-box transcription factor, PAX2, positively modulates expression of the Wilms' tumor suppressor gene (WT1). Oncogene. 1996;13:447-53 pubmed
    ..In this report, we demonstrate that PAX2 isoforms are capable of transactivating the wt1 promoter...
  6. Eccles M, He S, Legge M, Kumar R, Fox J, Zhou C, et al. PAX genes in development and disease: the role of PAX2 in urogenital tract development. Int J Dev Biol. 2002;46:535-44 pubmed
    ..Moreover, heterozygous mutations in several PAX genes cause human disease. Here we review the role of PAX2 in kidney development, focusing on the morphological effects of PAX2 mutations...
  7. Buttiglieri S, Deregibus M, Bravo S, Cassoni P, Chiarle R, Bussolati B, et al. Role of Pax2 in apoptosis resistance and proinvasive phenotype of Kaposi's sarcoma cells. J Biol Chem. 2004;279:4136-43 pubmed
    In this study, we found that Kaposi's sarcoma cells but not human microvascular endothelial cells expressed PAX2, a gene coding for a transcription factor involved both in organogenesis and tumorigenesis...
  8. Torban E, Dziarmaga A, Iglesias D, Chu L, Vassilieva T, Little M, et al. PAX2 activates WNT4 expression during mammalian kidney development. J Biol Chem. 2006;281:12705-12 pubmed
    The transcription factor PAX2 is expressed during normal kidney development and is thought to influence outgrowth and branching of the ureteric bud...
  9. Gupta R, Balzer B, Picken M, Osunkoya A, Shet T, Alsabeh R, et al. Diagnostic implications of transcription factor Pax 2 protein and transmembrane enzyme complex carbonic anhydrase IX immunoreactivity in adult renal epithelial neoplasms. Am J Surg Pathol. 2009;33:241-7 pubmed publisher
    ..These antibodies may reliably discriminate between clinically significant subtypes of RCC with overlapping cytoarchitectural features. ..

More Information

Publications110 found, 100 shown here

  1. Ward T, Nebel A, Reeve A, Eccles M. Alternative messenger RNA forms and open reading frames within an additional conserved region of the human PAX-2 gene. Cell Growth Differ. 1994;5:1015-21 pubmed
  2. Torban E, Eccles M, Favor J, Goodyer P. PAX2 suppresses apoptosis in renal collecting duct cells. Am J Pathol. 2000;157:833-42 pubmed
    b>PAX2 is a transcription factor belonging to the evolutionarily conserved paired box family and is required during development of the central nervous system and genitourinary axis...
  3. Tong G, Melamed J, Mansukhani M, Memeo L, Hernandez O, Deng F, et al. PAX2: a reliable marker for nephrogenic adenoma. Mod Pathol. 2006;19:356-63 pubmed
    ..In this study, we investigated the expression of a renal transcription factor, PAX2, in 39 nonrenal transplant-related nephrogenic adenomas, 100 adenocarcinomas of the prostate gland, and 47 ..
  4. Hueber P, Waters P, Clark P, Clarke P, Eccles M, Goodyer P. PAX2 inactivation enhances cisplatin-induced apoptosis in renal carcinoma cells. Kidney Int. 2006;69:1139-45 pubmed
    ..RCC cells overexpress the transcription factor, PAX2, normally expressed in fetal kidney but downregulated at birth...
  5. Bose S, Gibson W, Bullard R, Donald C. PAX2 oncogene negatively regulates the expression of the host defense peptide human beta defensin-1 in prostate cancer. Mol Immunol. 2009;46:1140-8 pubmed publisher
    ..However, the factors responsible for the loss of hBD1 expression are not known. PAX2, a transcriptional regulator normally expressed during early development, has been implicated as an oncogene in ..
  6. Eccles M, Wallis L, Fidler A, Spurr N, Goodfellow P, Reeve A. Expression of the PAX2 gene in human fetal kidney and Wilms' tumor. Cell Growth Differ. 1992;3:279-89 pubmed
    We have examined the pattern of expression of the human PAX2 gene in Wilms' tumors and human fetal kidney by Northern blot and in situ hybridization...
  7. Sanyanusin P, Norrish J, Ward T, Nebel A, McNoe L, Eccles M. Genomic structure of the human PAX2 gene. Genomics. 1996;35:258-61 pubmed
    b>PAX2 is one of nine PAX genes that have been described in vertebrates. Each PAX gene contains a conserved paired box domain that was first identified in Drosophila...
  8. Muratovska A, Zhou C, He S, Goodyer P, Eccles M. Paired-Box genes are frequently expressed in cancer and often required for cancer cell survival. Oncogene. 2003;22:7989-97 pubmed
    ..In addition, the PAX2 gene was frequently expressed in a panel of 406 common primary tumor tissues...
  9. Tong G, Chiriboga L, Hamele Bena D, Borczuk A. Expression of PAX2 in papillary serous carcinoma of the ovary: immunohistochemical evidence of fallopian tube or secondary Müllerian system origin?. Mod Pathol. 2007;20:856-63 pubmed
    b>PAX2 is a urogenital developmental transcription factor expressed in the Wolffian ducts, developing kidneys, and Müllerian ducts during embryonic stage...
  10. Tamimi Y, Ekuere U, Laughton N, Grundy P. WNT5A is regulated by PAX2 and may be involved in blastemal predominant Wilms tumorigenesis. Neoplasia. 2008;10:1470-80 pubmed
    The PAX2 gene encodes a transcription factor expressed during development...
  11. Luu V, Boysen G, Struckmann K, Casagrande S, von Teichman A, Wild P, et al. Loss of VHL and hypoxia provokes PAX2 up-regulation in clear cell renal cell carcinoma. Clin Cancer Res. 2009;15:3297-304 pubmed publisher
    The paired box gene 2, PAX2, encodes for a transcription factor that is up-regulated during nephrogenesis and becomes silenced in mature epithelium of the glomeruli, the proximal, and distal tubules...
  12. Mazal P, Stichenwirth M, Koller A, Blach S, Haitel A, Susani M. Expression of aquaporins and PAX-2 compared to CD10 and cytokeratin 7 in renal neoplasms: a tissue microarray study. Mod Pathol. 2005;18:535-40 pubmed
    ..Aquaporin-1 and PAX-2 are reliable markers for clear cell renal cell carcinomas of lower grades but not for higher grades. CD10 expression remains stable, independent of nuclear grading. ..
  13. Grajales Esquivel E, Luz Madrigal A, Bierly J, Haynes T, Reis E, Han Z, et al. Complement component C3aR constitutes a novel regulator for chick eye morphogenesis. Dev Biol. 2017;428:88-100 pubmed publisher
    ..The dorsal/ventral patterning defects were accompanied by an expansion of the ventral markers Pax2, cVax and retinoic acid synthesizing enzyme raldh-3 (aldh1a3) domains, an absence of the dorsal expression of Tbx5 ..
  14. Hu Z, Zhang Q, Qin W, Tong J, Zhao Q, Han Y, et al. Gene miles-apart is required for formation of otic vesicle and hair cells in zebrafish. Cell Death Dis. 2013;4:e900 pubmed publisher
    ..also caused abnormal expression of hearing-associated genes, including hmx2, fgf3, fgf8a, foxi1, otop1, pax2.1 and tmieb during zebrafish organogenesis...
  15. Bernstein C, Anderson M, Gohel C, Slater K, Gross J, Agarwala S. The cellular bases of choroid fissure formation and closure. Dev Biol. 2018;440:137-151 pubmed publisher
    ..the inter-CF space does not fuse or narrow and is instead loosely packed with migrating SOX2+/PAX2+/Vimentin+ astrocytes until it is closed by the outgoing optic nerve...
  16. Wen W, Pillai Kastoori L, Wilson S, Morris A. Sox4 regulates choroid fissure closure by limiting Hedgehog signaling during ocular morphogenesis. Dev Biol. 2015;399:139-153 pubmed publisher
    ..Sox4 morphants displayed altered proximo-distal patterning of the optic vesicle, including expanded pax2 expression in the optic stalk, as well as ectopic cell proliferation in the retina...
  17. Huang J, Liu Y, Filas B, Gunhaga L, Beebe D. Negative and positive auto-regulation of BMP expression in early eye development. Dev Biol. 2015;407:256-64 pubmed publisher
    ..b>Pax2 becomes undetectable and expression of Sfrp2 increases in the ventral optic cup, suggesting that increased BMP ..
  18. Rajakumar A, Senthilkumaran B. Sox3 binds to 11β-hydroxysteroid dehydrogenase gene promoter suggesting transcriptional interaction in catfish. J Steroid Biochem Mol Biol. 2016;158:90-103 pubmed publisher
    ..catfish genomic DNA library and in silico promoter analysis revealed putative TF binding sites such as Sox3, Wt1, Pax2, Dmrt1 and Ad4BP/SF-1...
  19. Lu Y, Li W. Functional characterization of E2F3b in human HepG2 liver cancer cell line. J Cell Biochem. 2017;: pubmed publisher
    ..Six genes, including CDC2, CCNE1, ARF, MAP4K2, MUSK and PAX2 were confirmed to be upregulated by more than twofold; one gene, CCNA2 was validated to be downregulated by more ..
  20. Shen J, Isaacson D, Cao M, Sinclair A, Cunha G, Baskin L. Immunohistochemical expression analysis of the human fetal lower urogenital tract. Differentiation. 2018;103:100-119 pubmed publisher
    ..The surface epithelium of the verumontanum is endodermal in origin (FOXA1-positive) with a possible contribution of Pax2-positive epithelial cells implying additional input from the Wolffian duct epithelium...
  21. Maliszewska Olejniczak K, Brodaczewska K, Bielecka Z, Czarnecka A. Three-Dimensional Cell Culture Model Utilization in Renal Carcinoma Cancer Stem Cell Research. Methods Mol Biol. 2018;1817:47-66 pubmed publisher
    ..promotes cell viability and stem-related gene expression including E-cadherin, N-cadherin, HIF1, HIF2, VEGF, Sox2, Pax2, and Nestin. 3D spheroid formation ability and spheroid volume increase are disturbed upon drug treatment...
  22. Sá S, Maia J, Bhowmick N, Silva S, Silva A, Correia da Silva G, et al. Uterine histopathological changes induced by acute administration of tamoxifen and its modulation by sex steroid hormones. Toxicol Appl Pharmacol. 2018;363:88-97 pubmed publisher
    ..In addition, EB induced PAX2 expression, an oncogene commonly found in epithelial tumors of the female genital tract, an effect that was ..
  23. Johnson Chacko L, Pechriggl E, Fritsch H, Rask Andersen H, Blumer M, Schrott Fischer A, et al. Neurosensory Differentiation and Innervation Patterning in the Human Fetal Vestibular End Organs between the Gestational Weeks 8-12. Front Neuroanat. 2016;10:111 pubmed
    ..At week 9, transcription factors PAX2 and PAX8 were observed in the hair cells whereas PAX6 was observed for the first time among the supporting cells of ..
  24. Wefers A, Lindner S, Schulte J, Schüller U. Overexpression of Lin28b in Neural Stem Cells is Insufficient for Brain Tumor Formation, but Induces Pathological Lobulation of the Developing Cerebellum. Cerebellum. 2017;16:122-131 pubmed publisher
    ..Finally, we found some residual Pax2-positive precursors of inhibitory interneurons in the ML of Nestin-Cre::lsl-Lin28b mice at p21, which have already ..
  25. Yang T, Kersigo J, Wu S, Fritzsch B, Bassuk A. Prickle1 regulates neurite outgrowth of apical spiral ganglion neurons but not hair cell polarity in the murine cochlea. PLoS ONE. 2017;12:e0183773 pubmed publisher
    ..this limited expression in the OC, cochlear HC PCP is unaffected in either Prickle1C251X/C251X mice or Prickle1f/f; Pax2-cre conditional null mice...
  26. Huang Z, He L, Huang D, Lei S, Gao J. Icariin protects rats against 5/6 nephrectomy-induced chronic kidney failure by increasing the number of renal stem cells. BMC Complement Altern Med. 2015;15:378 pubmed publisher
    ..Icariin inhibited the expression level of TGF-β1 whereas upregulated HGF, BMP-7, WT-1, and Pax2 expression...
  27. Qiu T, Teng Y, Tong J, Tao W, Xu L. Recurrent female adnexal tumor of probably Wolffian origin: A case report. Taiwan J Obstet Gynecol. 2017;56:382-384 pubmed publisher
    ..lesions were inhibin A, calretinin, estrogen receptor, progesterone receptor, cluster of differentiation 99, and Pax2 positive...
  28. Ponti G, Peretto P, Bonfanti L. Genesis of neuronal and glial progenitors in the cerebellar cortex of peripuberal and adult rabbits. PLoS ONE. 2008;3:e2366 pubmed publisher
    ..restricted to the molecular layer, giving rise to cells immunoreactive for GABA, and for the transcription factor Pax2, a marker for GABAergic cerebellar interneuronal precursors of neuroepithelial origin that ascend through the white ..
  29. Mesa H, Gilles S, Datta M, Murugan P, Larson W, Dachel S, et al. Comparative immunomorphology of testicular Sertoli and sertoliform tumors. Hum Pathol. 2017;61:181-189 pubmed publisher
    ..Distinctive phenotypes were identified in: sclerosing SCT: androgen receptors (AR) + (strong)/PAX2/PAX8+ (subset)/S100+/inhibin-; large cell calcifying SCT: calretinin+ (strong)/S100+/AR-; sertoliform RTA: PAX2/..
  30. Gutierrez Mecinas M, Watanabe M, Todd A. Expression of gastrin-releasing peptide by excitatory interneurons in the mouse superficial dorsal horn. Mol Pain. 2014;10:79 pubmed publisher
    ..EGFP+ cells in the GRP-EGFP mouse did not express Pax2, and their axons contained the vesicular glutamate transporter 2 (VGLUT2), indicating that they are excitatory ..
  31. Liu P, Gao Y, Huan J, Ge X, Tang Y, Shen W, et al. Upregulation of PAX2 promotes the metastasis of esophageal cancer through interleukin-5. Cell Physiol Biochem. 2015;35:740-54 pubmed publisher
    This study investigated the clinical relevance and biological function of paired box gene 2 (PAX2) in esophageal squamous cell carcinoma (ESCC)...
  32. Wollesen T, Rodríguez Monje S, Todt C, Degnan B, Wanninger A. Ancestral role of Pax2/5/8 in molluscan brain and multimodal sensory system development. BMC Evol Biol. 2015;15:231 pubmed publisher
    ..Accordingly, in ecdysozoan and vertebrate model organisms, orthologs of Pax2/5/8 are among others involved in the formation of the midbrain/hindbrain boundary, the auditory/geosensory organ ..
  33. Morrison C, Chen H, Cook T, Brown S, Treisman J. Glass promotes the differentiation of neuronal and non-neuronal cell types in the Drosophila eye. PLoS Genet. 2018;14:e1007173 pubmed publisher
    ..Coexpression of other transcription factors such as Pax2, Eyes absent, Lozenge and Escargot enabled Glass to induce additional genes characteristic of the non-neuronal cell ..
  34. Kopecky B, Santi P, Johnson S, Schmitz H, Fritzsch B. Conditional deletion of N-Myc disrupts neurosensory and non-sensory development of the ear. Dev Dyn. 2011;240:1373-90 pubmed publisher
    ..To investigate the function of N-Myc, we conditionally knocked out N-Myc in the ear using Tg(Pax2-Cre) and Foxg1(KiCre)...
  35. Imamura H, Ohishi Y, Aman M, Shida K, Shinozaki T, Yasutake N, et al. Ovarian high-grade serous carcinoma with a noninvasive growth pattern simulating a serous borderline tumor. Hum Pathol. 2015;46:1455-63 pubmed publisher
    ..aberrant p53 expression, frequent IMP3 positivity, p16 overexpression, a high MIB-1 labeling index, and infrequent PAX2. By molecular analysis, the pure HG-noninv and 13 HGSCs with HG-noninv showed TP53 mutations, but KRAS/BRAF ..
  36. Jiang G, Dai M, Huang K, Chai G, Chen J, Chen L, et al. Neurochemical characterization of pERK-expressing spinal neurons in histamine-induced itch. Sci Rep. 2015;5:12787 pubmed publisher
    ..On the other hand, approximately 7% of pERK-positive neurons expressed GAD67, and 27% of them contained Pax2. These results support the idea that pERK-expressing neurons serve as a component of local neuronal circuits for ..
  37. Ates Ozdemir D, Usubutun A. PAX2, PAX8 and CDX2 Expression in Metastatic Mucinous, Primary Ovarian Mucinous and Seromucinous Tumors and Review of the Literature. Pathol Oncol Res. 2016;22:593-9 pubmed publisher
    ..b>PAX2 and PAX8 immunohisyochemistries are useful for differentiating numerous primary tumour types from metastatic ones...
  38. Upson K, Allison K, Reed S, Jordan C, Newton K, Swisher E, et al. Biomarkers of progestin therapy resistance and endometrial hyperplasia progression. Am J Obstet Gynecol. 2012;207:36.e1-8 pubmed publisher
    ..We sought to identify biomarkers associated with progestin therapy resistance and persistence/progression of endometrial hyperplasia...
  39. Chen J, Fang X, Dang X, Wu X, Yi Z. Association of the paired box 2 gene polymorphism with the susceptibility and pathogenesis of Henoch‑Schönlein purpura in children. Mol Med Rep. 2015;11:1997-2003 pubmed publisher
    The present study aimed to investigate the distribution of paired box 2 (PAX2) gene polymorphisms in healthy populations and in patients with Henoch‑Schönlein purpura (HSP), focusing on the association between PAX2 gene ..
  40. Sun W, Huang L, Xu Y, Xiao X, Li S, Jia X, et al. Exome Sequencing on 298 Probands With Early-Onset High Myopia: Approximately One-Fourth Show Potential Pathogenic Mutations in RetNet Genes. Invest Ophthalmol Vis Sci. 2015;56:8365-72 pubmed publisher
    ..responsible for ocular diseases accompanied by high myopia, including COL2A1, COL11A1, PRPH2, FBN1, GNAT1, OPA1, PAX2, GUCY2D, TSPAN12, CACNA1F, and RPGR...
  41. Knutson T, Truong T, Ma S, Brady N, Sullivan M, Raj G, et al. Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs. J Hematol Oncol. 2017;10:89 pubmed publisher
    ..designated as PR-low to PR-null (luminal B) and included gene sets associated with cancer stem cell biology (HER2, PAX2, AHR, AR, RUNX)...
  42. Sletten E, Arnes M, Lyså L, Moe B, Straume B, Orbo A. Prediction of Relapse After Therapy Withdrawal in Women with Endometrial Hyperplasia: A Long-term Follow-up Study. Anticancer Res. 2017;37:2529-2536 pubmed
    ..B-cell lymphoma 2/apoptosis regulator (BCL2), BCL2-associated X protein/apoptosis regulator (BAX), paired box 2 (PAX2), and phosphatase and tensin homolog (PTEN) reported as H-scores. Over a follow-up of 157...
  43. Tamimi Y, Dietrich K, Stone K, Grundy P. Paired box genes, PAX-2 and PAX-8, are not frequently mutated in Wilms tumor. Mutat Res. 2006;601:46-50 pubmed
    ..In conclusion, no evidence for disease causing mutation was found using this technique, and so the direct involvement of either of these two genes in WT is unlikely. ..
  44. Roy N, Carneiro B, Ochs J. Glyphosate induces neurotoxicity in zebrafish. Environ Toxicol Pharmacol. 2016;42:45-54 pubmed publisher
    ..analysis, we detect decreases in genes expressed in the eye, fore and midbrain regions of the brain including pax2, pax6, otx2 and ephA4...
  45. Ren Y, Hou J, Xu A, Pan Y. Diagnostic utility of PAX2 and PAX5 in distinguishing non-small cell lung cancer from small cell lung cancer. Int J Clin Exp Pathol. 2015;8:14709-16 pubmed
    ..In this study, we examined the expression of PAX2 and PAX5 by immunohistochemistry in 47 cases of lung cancer and 13 cases of pneumonia...
  46. Bohuslavova R, Dodd N, Macova I, Chumak T, Horak M, Syka J, et al. Pax2-Islet1 Transgenic Mice Are Hyperactive and Have Altered Cerebellar Foliation. Mol Neurobiol. 2017;54:1352-1368 pubmed publisher
    ..role in the regulation of vestibulo-motor development, we investigated a transgenic mouse expressing Isl1 under the Pax2 promoter control (Tg +/- )...
  47. Juárez Morales J, Schulte C, Pezoa S, Vallejo G, Hilinski W, England S, et al. Evx1 and Evx2 specify excitatory neurotransmitter fates and suppress inhibitory fates through a Pax2-independent mechanism. Neural Dev. 2016;11:5 pubmed publisher
    ..factors that have been identified so far as specifying inhibitory fates in the spinal cord act through Pax2. Even Tlx1 and Tlx3, which specify the excitatory fates of dI3 and dI5 spinal neurons work at least in part by down-..
  48. Seigfried F, Cizelsky W, Pfister A, Dietmann P, Walther P, Kuhl M, et al. Frizzled 3 acts upstream of Alcam during embryonic eye development. Dev Biol. 2017;426:69-83 pubmed publisher
    ..In-depth analysis identified the jun N-terminal protein kinase 1 (JNK1) and the transcription factor paired box 2 (Pax2) to be important for the activation of alcam expression...
  49. Samimi S, Antignac C, Combe C, Lacombe D, Renaud Rougier M, Korobelnik J. Bilateral macular detachment caused by bilateral optic nerve malformation in a papillorenal syndrome due to a new PAX2 mutation. Eur J Ophthalmol. 2008;18:656-8 pubmed
    Papillorenal syndrome is an autosomal dominant entity due to PAX2 gene mutation, involving optic nerve and renal malformations.
  50. Cordell H, Darlay R, Charoen P, Stewart A, Gullett A, Lambert H, et al. Whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux. J Am Soc Nephrol. 2010;21:113-23 pubmed publisher
    ..We tested for but did not detect association with six candidate genes (AGTR2, HNF1B, PAX2, RET, ROBO2, and UPK3A)...
  51. Wang M, Ma H, Pan Y, Xiao W, Li J, Yu J, et al. PAX2 and PAX8 reliably distinguishes ovarian serous tumors from mucinous tumors. Appl Immunohistochem Mol Morphol. 2015;23:280-7 pubmed publisher
    ..quot; In this study, we examined the expression of PAX2 and PAX8 by immunohistochemistry in 58 cases of ovarian serous tumors and 68 cases of ovarian mucinous tumors...
  52. Puri P, Schaefer C, Bushnell D, Taglienti M, Kreidberg J, Yoder B, et al. Ectopic Phosphorylated Creb Marks Dedifferentiated Proximal Tubules in Cystic Kidney Disease. Am J Pathol. 2018;188:84-94 pubmed publisher
    ..Furthermore, lotus tetragonolobus lectin-negative/p-Creb-positive cyst segments (re)-expressed Ncam1, Pax2, and Sox9 markers of immature nephron structures and dedifferentiated proximal tubules after acute kidney injury...
  53. Jiang J, Rao Q, Xia Q, Tu P, Lu Z, Shen Q, et al. Sporadic hemangioblastoma of the kidney with PAX2 and focal CD10 expression: report of a case. Int J Clin Exp Pathol. 2013;6:1953-6 pubmed
    In this study, we presented an additional case of renal hemangioblastoma, which demonstrates PAX2 and focal CD10 expression. Histologically, the tumor consisted of sheets of oval or polygonal cells and a prominent vascular network...
  54. Lim R, Brichta A. Anatomical and physiological development of the human inner ear. Hear Res. 2016;338:9-21 pubmed publisher
    ..the development of prosensory and sensory regions of the fetal human cochlea using the transcription factors, PAX2, MAF-B, SOX2, and SOX9...
  55. Gutierrez Mecinas M, Bell A, Marin A, Taylor R, Boyle K, Furuta T, et al. Preprotachykinin A is expressed by a distinct population of excitatory neurons in the mouse superficial spinal dorsal horn including cells that respond to noxious and pruritic stimuli. Pain. 2017;158:440-456 pubmed publisher
    ..Over 80% of the PPTA-positive cells lack the transcription factor Pax2 (which determines an inhibitory phenotype), and these account for ?15% of the excitatory neurons in this region...
  56. Kaku Y, Taguchi A, Tanigawa S, Haque F, Sakuma T, Yamamoto T, et al. PAX2 is dispensable for in vitro nephron formation from human induced pluripotent stem cells. Sci Rep. 2017;7:4554 pubmed publisher
    ..The transcription factor PAX2 is essential for this mesenchymal-to-epithelial transition of nephron progenitors, as well as ureteric bud lineage ..
  57. Monteiro Carvalho Mori da Cunha M, Zia S, Oliveira Arcolino F, Carlon M, Beckmann D, Pippi N, et al. Amniotic Fluid Derived Stem Cells with a Renal Progenitor Phenotype Inhibit Interstitial Fibrosis in Renal Ischemia and Reperfusion Injury in Rats. PLoS ONE. 2015;10:e0136145 pubmed publisher
    ..In the first part of this study, hAFSCs that highly expressed CD24, CD117, SIX2 and PAX2 were isolated and characterized...
  58. Motojima M, Ogiwara S, Matsusaka T, Kim S, Sagawa N, Abe K, et al. Conditional knockout of Foxc2 gene in kidney: efficient generation of conditional alleles of single-exon gene by double-selection system. Mamm Genome. 2016;27:62-9 pubmed publisher
    ..To delete Foxc2 in mouse kidneys, floxed Foxc2 mice were mated with Pax2-Cre mice. Newborn Pax2-Cre; Foxc2(loxP/loxP) mice showed kidney hypoplasia and glomerular cysts...
  59. Lechner M, Levitan I, Dressler G. PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin. Nucleic Acids Res. 2000;28:2741-51 pubmed
    ..and characterization of a novel gene and its encoded protein, PTIP, which binds to the activation domain of Pax2 and other Pax proteins. PTIP binds to Pax2 in vitro, in the yeast two-hybrid assay and in tissue culture cells...
  60. Sharma R, Sanchez Ferras O, Bouchard M. Pax genes in renal development, disease and regeneration. Semin Cell Dev Biol. 2015;44:97-106 pubmed publisher
    ..In the urogenital system, Pax2 and Pax8 have emerged as crucial players at multiple steps of kidney and urinary tract development...
  61. Koppens M, Bounova G, Cornelissen Steijger P, de Vries N, Sansom O, Wessels L, et al. Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition. Oncotarget. 2016;7:69816-69828 pubmed publisher
    ..Response associated with the mutation status of ATRX and PAX2, and correlated with BIK expression...
  62. Gough S, McDonald M, Chen X, Korenberg J, Neri A, Kahn T, et al. Refined physical map of the human PAX2/HOX11/NFKB2 cancer gene region at 10q24 and relocalization of the HPV6AI1 viral integration site to 14q13.3-q21.1. BMC Genomics. 2003;4:9 pubmed
    ..a physical map showing that the order and chromosomal orientation of selected genes within 10q24 is CEN-CYP2C9-PAX2-HOX11-NFKB2-TEL...
  63. Bose S, Gibson W, Giri S, Nath N, Donald C. Angiotensin II up-regulates PAX2 oncogene expression and activity in prostate cancer via the angiotensin II type I receptor. Prostate. 2009;69:1334-42 pubmed publisher
    Paired homeobox 2 gene (PAX2) is a transcriptional regulator, aberrantly expressed in prostate cancer cells and its down-regulation promotes cell death in these cells...
  64. Ozcan A, Liles N, Coffey D, Shen S, Truong L. PAX2 and PAX8 expression in primary and metastatic müllerian epithelial tumors: a comprehensive comparison. Am J Surg Pathol. 2011;35:1837-47 pubmed publisher
    b>PAX2 and PAX8 are transcription factors that are essential in embryonic development of müllerian organs. They may also play a role in tumor development in these organs...
  65. Jia N, Wang J, Li Q, Tao X, Chang K, Hua K, et al. DNA methylation promotes paired box 2 expression via myeloid zinc finger 1 in endometrial cancer. Oncotarget. 2016;7:84785-84797 pubmed publisher
    This work investigated the role of paired box 2 (PAX2) in endometrial cancer and its epigenetic regulation mechanism...
  66. Mesa H, Zhang C, Manivel J, Ulbright T. Immunophenotypic comparison of testicular sclerosing Sertoli cell tumors and Sertoli cell tumors not otherwise specified. Hum Pathol. 2017;68:99-102 pubmed publisher
    ..In a recent study, differences in expression of PAX2/PAX8, inhibin, androgen receptor, and S100 protein between SCT-NOS and S-SCT were noted in a small number of cases...
  67. Higashide T, Wada T, Sakurai M, Yokoyama H, Sugiyama K. Macular abnormalities and optic disk anomaly associated with a new PAX2 missense mutation. Am J Ophthalmol. 2005;139:203-5 pubmed
    ..a family with macular abnormalities accompanied by anomalies of the optic disk and kidney associated with a new PAX2 missense mutation. Observational case report...
  68. Lee S, Doberstein K, Baumgarten P, Wieland A, Ungerer C, Burger C, et al. PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cells. PLoS ONE. 2011;6:e22312 pubmed publisher
    ..In this study, we investigated PAX2 protein levels in melanocytes and melanoma cells by Western Blot and immunofluorescence analysis and characterized ..
  69. Quick C, Ning G, Bijron J, Laury A, Wei T, Chen E, et al. PAX2-null secretory cell outgrowths in the oviduct and their relationship to pelvic serous cancer. Mod Pathol. 2012;25:449-55 pubmed publisher
    ..cell outgrowths (SCOUTs) in the oviduct are increased in frequency with concurrent serous cancer and typically lack PAX2 expression (PAX2-null)...
  70. Patrício P, Ramalho Carvalho J, Costa Pinheiro P, Almeida M, Barros Silva J, Vieira J, et al. Deregulation of PAX2 expression in renal cell tumours: mechanisms and potential use in differential diagnosis. J Cell Mol Med. 2013;17:1048-58 pubmed publisher
    Expression of PAX2 (Paired-box 2) is suppressed through promoter methylation at the later stages of embryonic development, but eventually reactivated during carcinogenesis...
  71. Gnemmi V, Leroy X, Triboulet J, Pruvot F, Villers A, Leteurtre E, et al. Pancreatic metastases of renal clear cell carcinoma: a clinicopathological study of 11 cases with special emphasis on the usefulness of PAX2 and mesothelin for the distinction from primary ductal adenocarcinoma of the pancreas. Anal Quant Cytopathol Histpathol. 2013;35:157-62 pubmed
    To determine whether PAX2 and mesothelin immunohistochemistry add additional diagnostic value in discriminating between pancreatic metastasis of renal clear cell carcinoma (PMRCC) and primary ductal adenocarcinoma of the pancreas (PDAC)...
  72. MCDANIEL A, Palanisamy N, Smith S, Robinson D, Wu Y, Chinnaiyan A, et al. A subset of solitary fibrous tumors express nuclear PAX8 and PAX2: a potential diagnostic pitfall. Histol Histopathol. 2016;31:223-30 pubmed publisher
    ..PAX8 and PAX2 are commonly used as renal tumor markers; however, no series has investigated PAX8 or PAX2 expression in SFT...
  73. Alwosaibai K, Abedini A, Al Hujaily E, Tang Y, Garson K, Collins O, et al. PAX2 maintains the differentiation of mouse oviductal epithelium and inhibits the transition to a stem cell-like state. Oncotarget. 2017;8:76881-76897 pubmed publisher
    ..Loss of PAX2 expression is recognized as an early event in epithelial transformation, but the specific role of PAX2 in this ..
  74. Hueber P, Iglesias D, Chu L, Eccles M, Goodyer P. In vivo validation of PAX2 as a target for renal cancer therapy. Cancer Lett. 2008;265:148-55 pubmed publisher
    ..In particular, aberrant PAX2 expression has been reported in a high proportion of primary tumors, including the majority of renal cell ..
  75. Karger A, Wilson J, Bower M, Schimmenti L, Thyagarajan B. Detection of PAX2 deletions and duplications using multiplex ligation-dependent probe amplification. Genet Test Mol Biomarkers. 2013;17:786-8 pubmed publisher
    Renal coloboma syndrome (RCS) is a rare inherited disorder caused by mutations in the PAX2 gene...
  76. de Miranda D, Dos Santos Júnior A, Dos Reis G, Freitas I, Carvalho T, de Marco L, et al. PAX2 polymorphisms and congenital abnormalities of the kidney and urinary tract in a Brazilian pediatric population: evidence for a role in vesicoureteral reflux. Mol Diagn Ther. 2014;18:451-7 pubmed publisher
    Congenital anomalies of the kidney and urinary tract (CAKUT) are common genetic malformations. Since the PAX2 gene has a role in kidney organogenesis, this study investigated the association of PAX2 gene polymorphisms with CAKUT in ..
  77. Yang J, He D, Peng Y, Zhong H, Deng Y, Yu Z, et al. Matrine suppresses the migration and invasion of NSCLC cells by inhibiting PAX2-induced epithelial-mesenchymal transition. Onco Targets Ther. 2017;10:5209-5217 pubmed publisher
    ..Western blotting and real-time polymerase chain reaction were applied to detect the expressions of PAX2, E-cadherin and N-cadherin...
  78. McConnell M, Cunliffe H, Chua L, Ward T, Eccles M. Differential regulation of the human Wilms tumour suppressor gene (WT1) promoter by two isoforms of PAX2. Oncogene. 1997;14:2689-700 pubmed
    b>PAX2 is a member of the paired box family of genes with an important role in kidney, genital tract and eye development. Another gene essential for kidney and genital tract development is the Wilms tumour gene, WT1...
  79. Salomon R, Tellier A, Attie Bitach T, Amiel J, Vekemans M, Lyonnet S, et al. PAX2 mutations in oligomeganephronia. Kidney Int. 2001;59:457-62 pubmed
    ..The mechanisms involved in this deficient nephrogenesis are unknown. The paired box transcription factor PAX2 plays a fundamental role in renal development...
  80. Ford B, Rupps R, Lirenman D, Van Allen M, Farquharson D, Lyons C, et al. Renal-coloboma syndrome: prenatal detection and clinical spectrum in a large family. Am J Med Genet. 2001;99:137-41 pubmed
    ..This syndrome is caused by mutations in the PAX2 gene and is transmitted as an autosomal dominant trait...
  81. Karafin M, Parwani A, Netto G, Illei P, Epstein J, Ladanyi M, et al. Diffuse expression of PAX2 and PAX8 in the cystic epithelium of mixed epithelial stromal tumor, angiomyolipoma with epithelial cysts, and primary renal synovial sarcoma: evidence supporting renal tubular differentiation. Am J Surg Pathol. 2011;35:1264-73 pubmed publisher
    ..The latter is supported by the extrarenal location of the epithelium in some cases. PAX2 and PAX8 are tissue-specific transcription factors expressed primarily in the renal and Müllerian systems and also ..
  82. Sallustio F, Serino G, Costantino V, Curci C, Cox S, De Palma G, et al. miR-1915 and miR-1225-5p regulate the expression of CD133, PAX2 and TLR2 in adult renal progenitor cells. PLoS ONE. 2013;8:e68296 pubmed publisher
    ..were recently identified in the cortex of the renal parenchyma and it was demonstrated that they were positive for PAX2, CD133, CD24 and exhibited multipotent differentiation ability...
  83. Browne J, Yang R, Song L, Crawford G, Leir S, Harris A. Open chromatin mapping identifies transcriptional networks regulating human epididymis epithelial function. Mol Hum Reprod. 2014;20:1198-207 pubmed publisher
    ..sites (TFBS) that were over-represented in the HEE open chromatin, including the motif for paired box 2 (PAX2)...
  84. Abraham S, Paknikar R, Bhumbra S, Luan D, Garg R, Dressler G, et al. The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor. J Biol Chem. 2015;290:7185-94 pubmed publisher
    ..we identify the phosphatase PPM1B as an essential component of the Groucho4 repressor complex that is recruited by Pax2 to chromatin...
  85. Wang D, Pan X, Ji J, Gu S, Sun X, Jiang C, et al. A large family with inherited optic disc anomalies: a correlation between a new genetic locus and complex ocular phenotypes. Sci Rep. 2017;7:7799 pubmed publisher
    ..However, no mutation was identified by exome sequencing or direct sequencing of PAX6 and PAX2 genes, suggesting that the mutation may reside within a regulatory element...
  86. Yoshimura K, Yoshida S, Yamaji Y, Komori A, Yoshida A, Hatae K, et al. De novo insG619 mutation in PAX2 gene in a Japanese patient with papillorenal syndrome. Am J Ophthalmol. 2005;139:733-5 pubmed
    ..Complete ophthalmologic and systemic examinations were performed, and direct genomic sequencing of the PAX2 gene. Fundus examination of a 3-year-old Japanese girl showed atypical coloboma bilaterally...
  87. Fonsato V, Buttiglieri S, Deregibus M, Puntorieri V, Bussolati B, Camussi G. Expression of Pax2 in human renal tumor-derived endothelial cells sustains apoptosis resistance and angiogenesis. Am J Pathol. 2006;168:706-13 pubmed
    The transcription factor Pax2 is known to play a key role during renal development and to act as an oncogene favoring renal tumor growth...
  88. Martinovic Bouriel J, Benachi A, Bonniere M, Brahimi N, Esculpavit C, Morichon N, et al. PAX2 mutations in fetal renal hypodysplasia. Am J Med Genet A. 2010;152A:830-5 pubmed publisher
    ..We report on two fetuses with PAX2 mutations presenting at 24 and 18 weeks' gestation, respectively, born into two different sibships...
  89. Burger M, Brucker D, Baumgarten P, Ronellenfitsch M, Wanka C, Hasselblatt M, et al. PAX2 is an antiapoptotic molecule with deregulated expression in medulloblastoma. Int J Oncol. 2012;41:235-41 pubmed publisher
    b>PAX2 is a paired box transcription factor possessing a fundamental role in the embryogenesis of hindbrain and urinary tract...
  90. Musah S, Mammoto A, Ferrante T, Jeanty S, Hirano Kobayashi M, Mammoto T, et al. Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip. Nat Biomed Eng. 2017;1: pubmed publisher
    ..stem (hiPS) cells into podocytes that express markers of the mature phenotype (nephrin+, WT1+, podocin+, Pax2-) and that exhibit primary and secondary foot processes...
  91. Jiang H, Li L, Yang H, Bai Y, Jiang H, Li Y. Pax2 may play a role in kidney development by regulating the expression of TBX1. Mol Biol Rep. 2014;41:7491-8 pubmed publisher
    ..b>Pax2 is a member of the "paired-box" (PAX) family of homeotic genes that orchestrates the patterns of gene ..
  92. Lin Z, Zhao J, Wang X, Zhu X, Gong L. Overexpression of microRNA-497 suppresses cell proliferation and induces apoptosis through targeting paired box 2 in human ovarian cancer. Oncol Rep. 2016;36:2101-7 pubmed publisher
    ..Luciferase assay was performed to verify a putative target site of miR-497 in the 3'UTR of PAX2 mRNA. The results showed that miR-497 was markedly decreased in ovarian cancer tissues and SKOV3 cells...