PARP

Summary

Gene Symbol: PARP
Description: poly(ADP-ribose) polymerase 1
Alias: ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1, poly [ADP-ribose] polymerase 1, ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase), ADP-ribosyltransferase NAD(+), ADP-ribosyltransferase diphtheria toxin-like 1, NAD(+) ADP-ribosyltransferase 1, poly (ADP-ribose) polymerase family, member 1, poly(ADP-ribose) synthetase, poly(ADP-ribosyl)transferase, poly[ADP-ribose] synthase 1
Species: human
Products:     PARP

Top Publications

  1. Nocchi L, Tomasetti M, Amati M, Neuzil J, Santarelli L, Saccucci F. Thrombomodulin is silenced in malignant mesothelioma by a poly(ADP-ribose) polymerase-1-mediated epigenetic mechanism. J Biol Chem. 2011;286:19478-88 pubmed publisher
    ..We propose that methylation of the TM promoter is responsible for silencing of TM expression in MM tissue, a process that is regulated by PARP1. ..
  2. Lönn P, van der Heide L, Dahl M, Hellman U, Heldin C, Moustakas A. PARP-1 attenuates Smad-mediated transcription. Mol Cell. 2010;40:521-32 pubmed publisher
    ..In an unbiased proteomic screen, we identified poly(ADP-ribose) polymerase-1 (PARP-1) as a Smad-interacting partner...
  3. Ahel D, Horejsí Z, Wiechens N, Polo S, Garcia Wilson E, Ahel I, et al. Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science. 2009;325:1240-3 pubmed publisher
    ..Furthermore, we show that depletion or overexpression of ALC1 results in sensitivity to DNA-damaging agents. Collectively, these results provide new insights into the mechanisms by which poly(ADP-ribose) regulates DNA repair. ..
  4. Heale J, Ball A, Schmiesing J, Kim J, Kong X, Zhou S, et al. Condensin I interacts with the PARP-1-XRCC1 complex and functions in DNA single-strand break repair. Mol Cell. 2006;21:837-48 pubmed
    ..the interphase-specific interaction between condensin I and the DNA nick-sensor poly(ADP-ribose) polymerase 1 (PARP-1)...
  5. Wang Z, Wang F, Tang T, Guo C. The role of PARP1 in the DNA damage response and its application in tumor therapy. Front Med. 2012;6:156-64 pubmed publisher
    ..The tumor-suppressor effects of PARP inhibitors have attracted significant interest for development of novel cancer therapies...
  6. Messner S, Altmeyer M, Zhao H, Pozivil A, Roschitzki B, Gehrig P, et al. PARP1 ADP-ribosylates lysine residues of the core histone tails. Nucleic Acids Res. 2010;38:6350-62 pubmed publisher
    ..Taken together, our computational and experimental results provide strong evidence that PARP1 modifies important regulatory lysines of the core histone tails. ..
  7. Krishnakumar R, Kraus W. PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway. Mol Cell. 2010;39:736-49 pubmed publisher
    b>PARP-1 is an abundant nuclear enzyme that regulates gene expression, although the underlying mechanisms are unclear...
  8. Kannan S, Fang W, Song G, Mullighan C, Hammitt R, McMurray J, et al. Notch/HES1-mediated PARP1 activation: a cell type-specific mechanism for tumor suppression. Blood. 2011;117:2891-900 pubmed publisher
    ..This mechanism shows a cell type-specific proapoptotic pathway that may lead to Notch agonist-based cancer therapeutics. ..
  9. Langelier M, Ruhl D, Planck J, Kraus W, Pascal J. The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction. J Biol Chem. 2010;285:18877-87 pubmed publisher
    b>PARP-1 is involved in multiple cellular processes, including transcription, DNA repair, and apoptosis...

More Information

Publications76

  1. Teo M, Landi D, Taylor C, Elliott F, Vaslin L, Cox D, et al. The role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes. Carcinogenesis. 2012;33:581-6 pubmed publisher
    ..The PARP-1 SNP rs8679 was also genotyped in a breast cancer case-control series (257 cases and 512 controls)...
  2. Brevik A, Joshi A, Corral R, Onland Moret N, Siegmund K, Le Marchand L, et al. Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat. Cancer Epidemiol Biomarkers Prev. 2010;19:3167-73 pubmed publisher
    ..study, we investigated the role of polymorphisms in 4 BER genes (APEX1 Gln51His, Asp148Glu; OGG1 Ser236Cys; PARP Val742Ala; and XRCC1 Arg194Trp, Arg280His, Arg399Gln) as potential CRC risk factors and modifiers of the ..
  3. Roszak A, Lianeri M, Sowińska A, Jagodziński P. Involvement of PARP-1 Val762Ala polymorphism in the onset of cervical cancer in caucasian women. Mol Diagn Ther. 2013;17:239-45 pubmed publisher
    Data on the Val762Ala (rs1136410) polymorphism in the poly(adenosine diphosphate [ADP]-ribose) polymerase 1 (PARP-1) gene as a risk factor for various types of cancers in different ethnicities are inconsistent...
  4. Galia A, Calogero A, Condorelli R, Fraggetta F, La Corte A, Ridolfo F, et al. PARP-1 protein expression in glioblastoma multiforme. Eur J Histochem. 2012;56:e9 pubmed publisher
    ..Poly (ADP-ribose) polymerase 1 (PARP-1) gene, located to 1q42, plays an important role for the efficient maintenance of genome integrity...
  5. Stern M, Butler L, Corral R, Joshi A, Yuan J, Koh W, et al. Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study. J Nutrigenet Nutrigenomics. 2009;2:273-9 pubmed publisher
    ..and 311 cases (180 colon and 131 rectal cancer) for SNPs in the XRCC1 (Arg194Trp, Arg399Gln), OGG1 (Ser326Cys), PARP (Val762Ala, Lys940Arg), and XPD (Asp312Asn, Lys751Gln) genes...
  6. Kang H, Lee Y, Shin J, Andrabi S, Chi Z, Gagné J, et al. Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage. Proc Natl Acad Sci U S A. 2011;108:14103-8 pubmed publisher
    ..These results define Iduna as a PAR-dependent E3 ligase that regulates cell survival and DNA repair. ..
  7. Ying S, Hamdy F, Helleday T. Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1. Cancer Res. 2012;72:2814-21 pubmed publisher
    b>PARP inhibitors are currently being used in clinical trials to treat BRCA1- or BRCA2-defective tumors, based on the synthetic lethal interaction between PARP1 and BRCA1/2-mediated homologous recombination (HR)...
  8. Jin X, Kim H, Lee I, Park K, Kim H, Choi J, et al. PARP-1 Val762Ala polymorphism is associated with reduced risk of non-Hodgkin lymphoma in Korean males. BMC Med Genet. 2010;11:38 pubmed publisher
    Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that plays a role in DNA repair, differentiation, proliferation, and cell death...
  9. Krishnakumar R, Kraus W. The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets. Mol Cell. 2010;39:8-24 pubmed publisher
    The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure, transcription, and genomic integrity, plays key roles in a wide variety of processes in the nucleus...
  10. Yu H, Ma H, Yin M, Wei Q. Association between PARP-1 V762A polymorphism and cancer susceptibility: a meta-analysis. Genet Epidemiol. 2012;36:56-65 pubmed publisher
    Poly(ADP-ribose) polymerase-1 (PARP-1 catalyzes poly(ADP-ribosyl)ation to various proteins involved in many cellular processes, including DNA damage detection and repair and cell proliferation and death...
  11. Kim J, Pyun J, Cho S, Lee K, Kwack K. Lymph node metastasis of gastric cancer is associated with the interaction between poly (ADP-ribose) polymerase 1 and matrix metallopeptidase 2. DNA Cell Biol. 2011;30:1011-7 pubmed publisher
    ..47, p?=?0.01; OR?=?2.28, p?=?0.01, respectively). In summary, PARP1 is associated with the risk of LNM of GC and the stage of LNM and tumor invasion. Epistasis between PARP1 rs1136410 and MMP2 rs243865 increased the risk of LNM of GC. ..
  12. Bey E, Reinicke K, Srougi M, VARNES M, Anderson V, Pink J, et al. Catalase abrogates ?-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers. Mol Cancer Ther. 2013;12:2110-20 pubmed publisher
    ..We predict that the ratio of NQO1:catalase activities in breast cancer versus associated normal tissue are likely to be the major determinants affecting the therapeutic window of ?-lapachone and other NQO1 bioactivatable drugs. ..
  13. Rodriguez M, Peralta Leal A, O Valle F, Rodríguez Vargas J, González Flores A, Majuelos Melguizo J, et al. PARP-1 regulates metastatic melanoma through modulation of vimentin-induced malignant transformation. PLoS Genet. 2013;9:e1003531 pubmed publisher
    b>PARP inhibition can induce anti-neoplastic effects when used as monotherapy or in combination with chemo- or radiotherapy in various tumor settings; however, the basis for the anti-metastasic activities resulting from PARP inhibition ..
  14. Tang L, Chen L, Qi M, Su Y, Su F, Lin Y, et al. Effects of passive smoking on breast cancer risk in pre/post-menopausal women as modified by polymorphisms of PARP1 and ESR1. Gene. 2013;524:84-9 pubmed publisher
    ..These results imply that the risk of breast cancer from passive smoking may be influenced by genetic factors, and that the association may differ depending on menopausal status. ..
  15. Mangerich A, Herbach N, Hanf B, Fischbach A, Popp O, Moreno Villanueva M, et al. Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1. Mech Ageing Dev. 2010;131:389-404 pubmed publisher
    Poly(ADP-ribose) polymerase-1 (PARP-1) is a sensor for DNA strand breaks and some unusual DNA structures and catalyzes poly(ADP-ribosyl)ation of nuclear proteins with NAD(+) serving as substrate...
  16. Zhang M, Qureshi A, Guo Q, Han J. Genetic variation in DNA repair pathway genes and melanoma risk. DNA Repair (Amst). 2011;10:111-6 pubmed publisher
    ..Further work on fine-mapping and on the functional characterization of this and linked SNPs in this region is required. ..
  17. Khodyreva S, Prasad R, Ilina E, Sukhanova M, Kutuzov M, Liu Y, et al. Apurinic/apyrimidinic (AP) site recognition by the 5'-dRP/AP lyase in poly(ADP-ribose) polymerase-1 (PARP-1). Proc Natl Acad Sci U S A. 2010;107:22090-5 pubmed publisher
    The capacity of human poly(ADP-ribose) polymerase-1 (PARP-1) to interact with intact apurinic/apyrimidinic (AP) sites in DNA has been demonstrated...
  18. Annunziata C, O Shaughnessy J. Poly (ADP-ribose) polymerase as a novel therapeutic target in cancer. Clin Cancer Res. 2010;16:4517-26 pubmed publisher
    ..Poly (ADP-ribose) polymerase (PARP) and BRCA proteins are central to the repair of DNA strand breaks and, when defective, lead to the accumulation of ..
  19. Sulzyc Bielicka V, Domagala P, Hybiak J, Majewicz Broda A, Safranow K, Domagala W. Colorectal cancers differ in respect of PARP-1 protein expression. Pol J Pathol. 2012;63:87-92 pubmed
    Recent findings raise the possibility of PARP inhibitor therapy in colorectal cancers (CRCs). However, the extent of PARP-1 protein expression in clinical specimens of CRC is not known...
  20. Lu H, Wang X, Li T, Urvalek A, Yu L, Li J, et al. Identification of poly (ADP-ribose) polymerase-1 (PARP-1) as a novel Kruppel-like factor 8-interacting and -regulating protein. J Biol Chem. 2011;286:20335-44 pubmed publisher
    ..co-IP), mass spectrometry, and GST pulldown assays, we identified poly(ADP-ribose) polymerase-1 (PARP-1) as a novel KLF8-interacting protein. Co-IP and Western blotting indicated that KLF8 is also a PARP-1 substrate...
  21. Huambachano O, Herrera F, Rancourt A, Satoh M. Double-stranded DNA binding domain of poly(ADP-ribose) polymerase-1 and molecular insight into the regulation of its activity. J Biol Chem. 2011;286:7149-60 pubmed publisher
    Poly(ADP-ribose) polymerase-1 (PARP-1) modifies various proteins, including itself, with ADP-ribose polymers (automodification)...
  22. Alanazi M, Pathan A, Shaik J, Amri A, Parine N. The C allele of a synonymous SNP (rs1805414, Ala284Ala) in PARP1 is a risk factor for susceptibility to breast cancer in Saudi patients. Asian Pac J Cancer Prev. 2013;14:3051-6 pubmed
    ..Confirmation of our findings in larger populations of different ethnicities may provide evidence for a role of the PARP1 gene in breast carcinoma developnment. ..
  23. Adamson B, Smogorzewska A, Sigoillot F, King R, Elledge S. A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nat Cell Biol. 2012;14:318-28 pubmed publisher
    ..Our screen also revealed that off-target depletion of RAD51 is a common source of RNAi false positives, raising a cautionary note for siRNA screens and RNAi-based studies of HR. ..
  24. Kashima L, Idogawa M, Mita H, Shitashige M, Yamada T, Ogi K, et al. CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation. J Biol Chem. 2012;287:12975-84 pubmed publisher
    ..Here we show poly(ADP-ribose) polymerase 1 (PARP-1) to be a novel CHFR-interacting protein...
  25. Lilyestrom W, van der Woerd M, Clark N, Luger K. Structural and biophysical studies of human PARP-1 in complex with damaged DNA. J Mol Biol. 2010;395:983-94 pubmed publisher
    The enzyme poly(ADP-ribose) polymerase-1 (PARP-1) is a global monitor of chromatin structure and DNA damage repair...
  26. Robu M, Shah R, Petitclerc N, Brind Amour J, Kandan Kulangara F, Shah G. Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair. Proc Natl Acad Sci U S A. 2013;110:1658-63 pubmed publisher
    ..of mammalian cells to DNA damage is catalytic activation of a nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1)...
  27. Zhang P, Nakatsukasa H, Tu E, Kasagi S, Cui K, Ishikawa M, et al. PARP-1 regulates expression of TGF-? receptors in T cells. Blood. 2013;122:2224-32 pubmed publisher
    ..We show here that Poly(ADP-ribose) polymerase-1 (PARP-1) regulates TGF-? receptor I (T?RI) and II (T?RII) expression in CD4(+) T cells and subsequently affects Smad2/3-..
  28. Min W, Bruhn C, Grigaravicius P, Zhou Z, Li F, Krüger A, et al. Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation. Nat Commun. 2013;4:2993 pubmed publisher
    ..Collectively, we disclose a previously unrecognized mechanism of the S-phase checkpoint by PAR metabolism that modulates Chk1 activity at the replication fork. ..
  29. Fatokun A, Dawson V, Dawson T. Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities. Br J Pharmacol. 2014;171:2000-16 pubmed publisher
    ..of disorders, in part, via parthanatos, a process dependent on the activity of poly (ADP-ribose)-polymerase (PARP)...
  30. Park E, Min K, Lee T, Yoo Y, Kim Y, Kwon T. ?-Lapachone induces programmed necrosis through the RIP1-PARP-AIF-dependent pathway in human hepatocellular carcinoma SK-Hep1 cells. Cell Death Dis. 2014;5:e1230 pubmed publisher
    ..In addition, ?-lapachone activated poly (ADP-ribosyl) polymerase-1(PARP-1) and promoted AIF release, and DPQ (a PARP-1 specific inhibitor) or AIF siRNA blocked ?-lapachone-induced cell ..
  31. Bacalini M, Tavolaro S, Peragine N, Marinelli M, Santangelo S, del Giudice I, et al. A subset of chronic lymphocytic leukemia patients display reduced levels of PARP1 expression coupled with a defective irradiation-induced apoptosis. Exp Hematol. 2012;40:197-206.e1 pubmed publisher
    ..primary cells from 21 untreated patients were analyzed for in vitro response to irradiation through Western blot, PARP activity assay, Annexin-V analysis, and PARP1 basal expression by quantitative polymerase chain reaction...
  32. Wang M, Qin C, Zhu J, Yuan L, Fu G, Zhang Z, et al. Genetic variants of XRCC1, APE1, and ADPRT genes and risk of bladder cancer. DNA Cell Biol. 2010;29:303-11 pubmed publisher
    ..carcinogens could be removed effectively by the base excision repair pathway, in which the XRCC1, APE1, and ADPRT genes play a key role...
  33. Leung M, Rosen D, Fields S, Cesano A, Budman D. Poly(ADP-ribose) polymerase-1 inhibition: preclinical and clinical development of synthetic lethality. Mol Med. 2011;17:854-62 pubmed publisher
    ..dependence on alternate DNA repair processes by base excision repair, which requires poly(ADP-ribose) polymerase 1 (PARP-1)...
  34. Kase M, Vardja M, Lipping A, Asser T, Jaal J. Impact of PARP-1 and DNA-PK expression on survival in patients with glioblastoma multiforme. Radiother Oncol. 2011;101:127-31 pubmed publisher
    ..Tumor sections were examined for poly-ADP ribose polymerase-1 (PARP-1) and DNA protein kinase (DNA-PK) expression...
  35. Fekete A, Kenesi E, Hunyadi Gulyas E, Durgo H, Berko B, Dunai Z, et al. The guanine-quadruplex structure in the human c-myc gene's promoter is converted into B-DNA form by the human poly(ADP-ribose)polymerase-1. PLoS ONE. 2012;7:e42690 pubmed publisher
    ..Here we present evidences, that the human nuclear poly(ADP-ribose)polymerase-1 (h PARP-1) protein participates in the regulation of the h c-myc gene expression through its interaction with this GQ ..
  36. Módis K, Gero D, Erdélyi K, Szoleczky P, DEWITT D, Szabo C. Cellular bioenergetics is regulated by PARP1 under resting conditions and during oxidative stress. Biochem Pharmacol. 2012;83:633-43 pubmed publisher
    ..While PARP1 is a regulator of oxidative phosphorylation in resting and oxidatively stressed cells, it only exerts a minor effect on glycolysis. ..
  37. Noren Hooten N, Kompaniez K, Barnes J, Lohani A, Evans M. Poly(ADP-ribose) polymerase 1 (PARP-1) binds to 8-oxoguanine-DNA glycosylase (OGG1). J Biol Chem. 2011;286:44679-90 pubmed publisher
    ..Here we report a novel interaction between OGG1 and Poly(ADP-ribose) polymerase 1 (PARP-1), a DNA-damage sensor protein involved in DNA repair and many other cellular processes...
  38. Farrar D, Rai S, Chernukhin I, Jagodic M, Ito Y, Yammine S, et al. Mutational analysis of the poly(ADP-ribosyl)ation sites of the transcription factor CTCF provides an insight into the mechanism of its regulation by poly(ADP-ribosyl)ation. Mol Cell Biol. 2010;30:1199-216 pubmed publisher
    ..The association and simultaneous presence of PARP-1 and CTCF at the ICR, confirmed by single and serial chromatin immunoprecipitation assays, were found to be ..
  39. King B, Cooper K, Liu K, Hudson L. Poly(ADP-ribose) contributes to an association between poly(ADP-ribose) polymerase-1 and xeroderma pigmentosum complementation group A in nucleotide excision repair. J Biol Chem. 2012;287:39824-33 pubmed publisher
    ..Poly(ADP-ribose) polymerase-1 (PARP-1) is a zinc finger protein with well documented involvement in base excision repair...
  40. Ye F, Cheng Q, Hu Y, Zhang J, Chen H. PARP-1 Val762Ala polymorphism is associated with risk of cervical carcinoma. PLoS ONE. 2012;7:e37446 pubmed publisher
    b>PARP-1 is a nuclear enzyme that plays an important role in DNA repair, recombination, proliferation and the genome stability...
  41. Nagy E, Caidahl K, Franco Cereceda A, Bäck M. Increased transcript level of poly(ADP-ribose) polymerase (PARP-1) in human tricuspid compared with bicuspid aortic valves correlates with the stenosis severity. Biochem Biophys Res Commun. 2012;420:671-5 pubmed publisher
    ..of aortic valve stenosis, and is associated with activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) 1...
  42. Gao R, Price D, Dahut W, Reed E, Figg W. Genetic polymorphisms in XRCC1 associated with radiation therapy in prostate cancer. Cancer Biol Ther. 2010;10:13-8 pubmed
    ..034). This association was not found when all patients were investigated. We conclude that the genetic polymorphisms in XRCC1 may affect the outcome in patients who received radiotherapy for localized prostate cancer. ..
  43. Klauschen F, von Winterfeld M, Stenzinger A, Sinn B, Budczies J, Kamphues C, et al. High nuclear poly-(ADP-ribose)-polymerase expression is prognostic of improved survival in pancreatic cancer. Histopathology. 2012;61:409-16 pubmed publisher
    ..In the pancreas, PARP expression has so far only been studied in inflammatory conditions...
  44. Yan Q, Xu R, Zhu L, Cheng X, Wang Z, Manis J, et al. BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8. Mol Cell Biol. 2013;33:845-57 pubmed publisher
    ..These data establish that BAL1 and BBAP are bona fide members of a DNA damage response pathway and are directly associated with PARP1 activation, BRCA1 recruitment, and double-strand break repair. ..
  45. Li Y, Li S, Wu Z, Hu F, Zhu L, Zhao X, et al. Polymorphisms in genes of APE1, PARP1, and XRCC1: risk and prognosis of colorectal cancer in a northeast Chinese population. Med Oncol. 2013;30:505 pubmed publisher
    ..polymorphisms (SNPs) in genes of apurinic/apyrimidinic endonuclease-1 (APE1), ADP-ribosyltransferase (ADPRT, also known as PARP1), and X-ray repair cross-complementing groups 1 (XRCC1) were tested by PCR-RFLP...
  46. Sand Dejmek J, Adelmant G, Sobhian B, Calkins A, Marto J, Iglehart D, et al. Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin. Mol Cancer. 2011;10:74 pubmed publisher
    ..Silencing FACT however, allows both apoptosis and necrosis. Targeting DNA repair in cancer patients may have different therapeutic effects depending upon the roles played by factors targeted. ..
  47. Langelier M, Planck J, Roy S, Pascal J. Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1. Science. 2012;336:728-32 pubmed publisher
    Poly(ADP-ribose) polymerase-1 (PARP-1) (ADP, adenosine diphosphate) has a modular domain architecture that couples DNA damage detection to poly(ADP-ribosyl)ation activity through a poorly understood mechanism...
  48. Beneke S, Scherr A, Ponath V, Popp O, Burkle A. Enzyme characteristics of recombinant poly(ADP-ribose) polymerases-1 of rat and human origin mirror the correlation between cellular poly(ADP-ribosyl)ation capacity and species-specific life span. Mech Ageing Dev. 2010;131:366-9 pubmed publisher
    ..e. man and rat) is directly mirrored by the enzymatic parameters of recombinant poly(ADP-ribose) polymerase-1 (PARP-1), i.e. substrate affinity and reaction velocity...
  49. Lee Y, Karuppagounder S, Shin J, Lee Y, Ko H, Swing D, et al. Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss. Nat Neurosci. 2013;16:1392-400 pubmed publisher
    ..These data indicate that brain-permeable PARP inhibitors could effectively delay or prevent disease progression in Parkinson's disease.
  50. Gan A, Green A, Nolan C, Martin S, Deen S. Poly(adenosine diphosphate-ribose) polymerase expression in BRCA-proficient ovarian high-grade serous carcinoma; association with patient survival. Hum Pathol. 2013;44:1638-47 pubmed publisher
    ..BRCA mutations rely on the alternative DNA repair mechanism of the poly(adenosine diphosphate-ribose) polymerases (PARP)-dependent base excision repair pathway, with a better overall survival and response to chemotherapy, than BRCA1-..
  51. Gottschalk A, Trivedi R, Conaway J, Conaway R. Activation of the SNF2 family ATPase ALC1 by poly(ADP-ribose) in a stable ALC1·PARP1·nucleosome intermediate. J Biol Chem. 2012;287:43527-32 pubmed publisher
    ..Taken together, our findings are consistent with the model that PAR present on PARylated PARP1 acts as an allosteric effector of ALC1 nucleosome remodeling activity. ..
  52. Macgregor S, Montgomery G, Liu J, Zhao Z, Henders A, Stark M, et al. Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3. Nat Genet. 2011;43:1114-8 pubmed publisher
    ..3 locus span a region with ten genes, and plausible candidate genes for melanoma susceptibility include ARNT and SETDB1. Variants at the 1q21.3 locus do not seem to be associated with human pigmentation or measures of nevus density. ..
  53. Madison D, Lundblad J. C-terminal binding protein and poly(ADP)ribose polymerase 1 contribute to repression of the p21(waf1/cip1) promoter. Oncogene. 2010;29:6027-39 pubmed publisher
    ..We found that restraint of basal p21 transcription requires both CtBP and PARP1. PARP inhibition attenuated activation of p21 transcription by both p53-independent and p53-dependent processes, in a ..
  54. Campalans A, Kortulewski T, Amouroux R, Menoni H, Vermeulen W, Radicella J. Distinct spatiotemporal patterns and PARP dependence of XRCC1 recruitment to single-strand break and base excision repair. Nucleic Acids Res. 2013;41:3115-29 pubmed publisher
    ..XRCC1 is recruited to SSBR by PARP-1, responsible for the initial recognition of the break. The recruitment of XRCC1 to BER is still poorly understood...
  55. Pan X, Xie Y, Loh M, Yang S, Wen Y, Tian Z, et al. Polymorphisms of XRCC1 and ADPRT genes and risk of noncardia gastric cancer in a Chinese population: a case-control study. Asian Pac J Cancer Prev. 2012;13:5637-42 pubmed
    ..noted that XRCC1 Arg194Trp was associated with GC risk in Western China in a study on XRCC1 Arg194Trp and ADPRT Val762Ala. We aimed to further explore the association of these polymorphisms with risk of the noncardia subtype...
  56. Noren Hooten N, Fitzpatrick M, Kompaniez K, Jacob K, Moore B, Nagle J, et al. Coordination of DNA repair by NEIL1 and PARP-1: a possible link to aging. Aging (Albany NY). 2012;4:674-85 pubmed
    ..Recently, we reported that OGG1 binds to the Poly(ADP-ribose) polymerase 1 (PARP-1), a DNA damage sensor protein that poly(ADP-ribosyl)ates nuclear proteins in response to DNA damage and other ..
  57. Pines A, Vrouwe M, Marteijn J, Typas D, Luijsterburg M, Cansoy M, et al. PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1. J Cell Biol. 2012;199:235-49 pubmed publisher
  58. Yosunkaya E, Kucukyuruk B, Onaran I, Gurel C, Uzan M, Kanigur Sultuybek G. Glioma risk associates with polymorphisms of DNA repair genes, XRCC1 and PARP1. Br J Neurosurg. 2010;24:561-5 pubmed publisher
    ..We also suspect that in the presence of a polymorphic (G) allele of XRCC1, the plausible protective effect of PARP1 VA genotype may be greatly suppressed. ..
  59. Rodriguez M, González Flores A, Dantzer F, Collard J, de Herreros A, Oliver F. Poly(ADP-ribose)-dependent regulation of Snail1 protein stability. Oncogene. 2011;30:4365-72 pubmed publisher
    ..It has been previously shown that poly(ADP-ribose) polymerase-1 (PARP-1) knockdown, but not PARP inhibition, downregulates the expression of Snail1...
  60. He W, Liu T, Shan Y, Zhu K, Li Y. PARP1 polymorphisms increase the risk of gastric cancer in a Chinese population. Mol Diagn Ther. 2012;16:35-42 pubmed publisher
    ..The study suggests that the PARP1 2819G allele is associated with an increased risk of GC. In addition, H. pylori-positive status and family history jointly contribute to a higher risk of GC. ..
  61. Rojo F, García Parra J, Zazo S, Tusquets I, Ferrer Lozano J, Menendez S, et al. Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer. Ann Oncol. 2012;23:1156-64 pubmed publisher
    Poly(ADP-ribose)polymerase-1 (PARP-1) is a highly promising novel target in breast cancer. However, the expression of PARP-1 protein in breast cancer and its associations with outcome are yet poorly characterized...
  62. Pabalan N, Francisco Pabalan O, Jarjanazi H, Li H, Sung L, Ozcelik H. Racial and tissue-specific cancer risk associated with PARP1 (ADPRT) Val762Ala polymorphism: a meta-analysis. Mol Biol Rep. 2012;39:11061-72 pubmed publisher
    The Val762Ala polymorphism poly [ADP-ribose] polymerase 1 (PARP1) gene [ADPRT (adenosine diphosphate ribosyltransferase) gene] affects enzymatic activity, which modulates cancer susceptibility among human populations...
  63. Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, et al. SIRT6 promotes DNA repair under stress by activating PARP1. Science. 2011;332:1443-6 pubmed publisher
  64. Ohanna M, Giuliano S, Bonet C, Imbert V, Hofman V, Zangari J, et al. Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS). Genes Dev. 2011;25:1245-61 pubmed publisher
    ..between senescence induction and secretome formation by revealing that the poly(ADP-ribose) polymerase-1 (PARP-1)/nuclear factor-?B (NF-?B) signaling cascade, activated during senescence, drives the formation of a secretome ..
  65. Ahmad M, Torky A, Glahn F, Scheubel R, Foth H. PARP-1 expression and activity in primary human lung cells. Arch Toxicol. 2011;85:669-79 pubmed publisher
    Activation of poly(ADP-ribose) polymerase-1 (PARP-1) in response to DNA damage is an important mechanism to keep homeostasis or to trigger apoptosis...
  66. Ali A, Timinszky G, Arribas Bosacoma R, Kozlowski M, Hassa P, Hassler M, et al. The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks. Nat Struct Mol Biol. 2012;19:685-692 pubmed publisher
  67. Dong Y, Bey E, Li L, Kabbani W, Yan J, Xie X, et al. Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation. Cancer Res. 2010;70:8088-96 pubmed publisher
    ..induction of reactive oxygen species, irreversible DNA single-strand breaks (SSB), poly(ADP-ribose) polymerase-1 (PARP-1) hyperactivation, NAD(+)/ATP depletion, and ?-calpain-induced programmed necrosis...