PARN

Summary

Gene Symbol: PARN
Description: poly(A)-specific ribonuclease
Alias: DAN, DKCB6, PFBMFT4, poly(A)-specific ribonuclease PARN, deadenylating nuclease, deadenylation nuclease, polyadenylate-specific ribonuclease
Species: human
Products:     PARN

Top Publications

  1. Maliqueo M, Sundström Poromaa I, Vanky E, Fornes R, Benrick A, Åkerud H, et al. Placental STAT3 signaling is activated in women with polycystic ovary syndrome. Hum Reprod. 2015;30:692-700 pubmed publisher
    ..The work was supported by the Swedish Medical Research Council (Project No. 2011-2732 and 2014-2775); Jane and Dan Olsson Foundation, Wilhelm and Martina Lundgrens's Science Fund; Hjalmar Svensson Foundation (E.S.-V and M.M...
  2. Carrera Boada C, Martínez Moreno J. Pathophysiology of diabetes mellitus type 2: beyond the duo "insulin resistance-secretion deficit". Nutr Hosp. 2013;28 Suppl 2:78-87 pubmed publisher
    ..provocado por el exceso de carga de trabajo debido a la sobreproducción en la biosíntesis de insulina e IAPP dan como resultado la apoptosis de las células ?...
  3. Shah P, Herbozo C, Aliwalas L, Shah V. Breastfeeding or breast milk for procedural pain in neonates. Cochrane Database Syst Rev. 2012;12:CD004950 pubmed publisher
    ..Douleur Aigue Nouveau-ne scores (DAN) were significantly lower in the breastfeeding group compared to the placebo group and the group held in mother's ..
  4. Li J, Gao L, Sun K, Xiao D, Li W, Xiang L, et al. Benzoate fraction from Gentiana rigescens Franch alleviates scopolamine-induced impaired memory in mice model in vivo. J Ethnopharmacol. 2016;193:107-116 pubmed publisher
    G. rigescens Franch (Long Dan Cao in Chinese) is a well-known TCM herb. It is clinically used with other drugs for the treatment of brain diseases such as epilepsy, postherpetic neuralgia in China...
  5. Kadıköylü V, Meteoglu I, Demir S, Aybek H, Kalak M, Balkaya M, et al. The protection of the myocardium by amifostine against mitoxantrone-induced acute cardiotoxicity in rats. Turk J Haematol. 2010;27:62-9 pubmed publisher
    ..5 ve 5 mg/kg ald?. MITO 2.5+AMI ve MITO 5+AMI gruplar?nda ayn? dozlarda MITO’dan 30 dk önce 200 mg/kg AMI uyguland?...
  6. Skeparnias I, Αnastasakis D, Shaukat A, Grafanaki K, Stathopoulos C. Expanding the repertoire of deadenylases. RNA Biol. 2017;14:1320-1325 pubmed publisher
    ..to an expanding family of exoribonucleases involved mainly in mRNA stability and turnover, with the exception of PARN which has additional roles in the biogenesis of several important non-coding RNAs, including miRNAs and piRNAs...
  7. Li Y, Wang Y. Bioinformatics analysis of gene expression data for the identification of critical genes in breast invasive carcinoma. Mol Med Rep. 2017;16:8657-8664 pubmed publisher
    ..In addition, TFs, including Sp1 transcription factor, DAN domain BMP antagonist family member 5, MYCN proto?oncogene, bHLH transcription factor and cAMP responsive element ..
  8. Wu X, Gu Y, Li L. The anti-hyperplasia, anti-oxidative and anti-inflammatory properties of Qing Ye Dan and swertiamarin in testosterone-induced benign prostatic hyperplasia in rats. Toxicol Lett. 2017;265:9-16 pubmed publisher
    Qing Ye Dan (QYD) is the whole plant of Swertia mileensis and used in Chinese folk medicine for the treatment of prostatitis, benign prostatic hyperplasia (BPH) and so on...
  9. Brännström M, Johannesson L, Bokström H, Kvarnström N, Mölne J, Dahm Kähler P, et al. Livebirth after uterus transplantation. Lancet. 2015;385:607-616 pubmed publisher
    ..Furthermore, the results show the feasibility of live uterus donation, even from a postmenopausal donor. Jane and Dan Olsson Foundation for Science.

More Information

Publications144 found, 100 shown here

  1. Chan S, Tekari A, Benneker L, Heini P, Gantenbein B. Osteogenic differentiation of bone marrow stromal cells is hindered by the presence of intervertebral disc cells. Arthritis Res Ther. 2015;18:29 pubmed publisher
    ..disc calcification, such as bone morphogenetic protein (BMP) antagonists including noggin and members of the DAN (differential screening selected gene aberrative in neuroblastoma) family...
  2. Lee Y, Wang T, Chen S, Lin H, Tsai M. Management of viral oral ulcers in children using Chinese herbal medicine: A report of two cases. Complement Ther Med. 2017;32:61-65 pubmed publisher
    ..both were treated using the same herbal formulas powder prescription, named Liang Ge San (LGS) and Gan Lu Xiao Du Dan (GLXDD). After several days of CHM treatment, the oral ulcers were in regression...
  3. Tsai F, Ho T, Cheng C, Liu X, Tsang H, Lin T, et al. Effect of Chinese herbal medicine on stroke patients with type 2 diabetes. J Ethnopharmacol. 2017;200:31-44 pubmed publisher
    ..37, 95% confidence interval [0.25-0.55]). Shu-Jing-Huo-Xue-Tang, Xue-Fu-Zhu-Yu-Tang, and Du-Huo-Ji-Sheng-Tang; and Dan-Shen, Niu-Xi, and Yan-Hu-Suo represented the top three formulas and herbs, respectively...
  4. López Malo M, García Ríos E, Melgar B, Sanchez M, Dunham M, Guillamón J. Evolutionary engineering of a wine yeast strain revealed a key role of inositol and mannoprotein metabolism during low-temperature fermentation. BMC Genomics. 2015;16:537 pubmed publisher
    ..and parental strains showed the greatest up-regulation in four mannoprotein coding genes, which belong to the DAN/TIR family (DAN1, TIR1, TIR4 and TIR3)...
  5. Ren X, Xue J, Wang S, Xue Y, Zhang P, Jiang H, et al. Proteomic analysis of tree peony (Paeonia ostii 'Feng Dan') seed germination affected by low temperature. J Plant Physiol. 2018;224-225:56-67 pubmed publisher
  6. Ting C, Cheng Y, Tsai T. Herb-Drug Interaction between the Traditional Hepatoprotective Formulation and Sorafenib on Hepatotoxicity, Histopathology and Pharmacokinetics in Rats. Molecules. 2017;22: pubmed publisher
    ..mechanism of drug-drug interactions of sorafenib including interacting with hepatoprotective formulation, Long-Dan-Xie-Gan-Tang formulation (LDXGT) and with two cytochrome P450 3A4 (CYP3A4) inhibitors, grapefruit juice and ..
  7. Maryoung L, Yue Y, Young A, Newton C, Barba C, van Oers N, et al. Somatic mutations in telomerase promoter counterbalance germline loss-of-function mutations. J Clin Invest. 2017;127:982-986 pubmed publisher
    ..5% of individuals with inherited loss-of-function coding mutations in TERT or poly(A)-specific ribonuclease (PARN), another gene linked to telomerase function...
  8. Anastasakis D, Skeparnias I, Shaukat A, Grafanaki K, Kanellou A, Taraviras S, et al. Mammalian PNLDC1 is a novel poly(A) specific exonuclease with discrete expression during early development. Nucleic Acids Res. 2016;44:8908-8920 pubmed
    PNLDC1 is a homologue of poly(A) specific ribonuclease (PARN), a known deadenylase with additional role in processing of non-coding RNAs. Both enzymes were reported recently to participate in piRNA biogenesis in silkworm and C...
  9. Chang C, Lee Y, Lin C, Chang C, Chiu C, Chou L, et al. Characteristics of traditional Chinese medicine usage in patients with stroke in Taiwan: A nationwide population-based study. J Ethnopharmacol. 2016;186:311-321 pubmed publisher
    ..Bu-yang-huan-wu-tang and Dan-shen (Radix Salviae Miltiorrhizae; Salvia miltiorrhiza Bunge) was the most commonly prescribed Chinese herbal ..
  10. Rinaldi I. The Role of Reed-Sternberg CD30 Receptor and Lymphocytes in Pathogenesis of Disease and Its Implication for Treatment. Acta Med Indones. 2018;50:93-95 pubmed
    ..conjugate, Brentuximab vedotin, was approved by Food Drug Association and European Medicine since 2011 dan was approved by European Medicine Agency since 2012 to treat relapsed classical Hodgkin lymphoma and anaplastic ..
  11. Wu Q, Wong Z, Wang C, Fung A, Wong E, Chan G, et al. Isoorientin derived from Gentiana veitchiorum Hemsl. flowers inhibits melanogenesis by down-regulating MITF-induced tyrosinase expression. Phytomedicine. 2018;57:129-136 pubmed publisher
    ..The roots of few species of Gentiana, also known as Long Dan Cao in Chinese, are traditionally used in herbal remedies for a wide variety of liver-associated diseases...
  12. Johnson J, Thürich J, Petutschnig E, Altschmied L, Meichsner D, Sherameti I, et al. A Poly(A) Ribonuclease Controls the Cellotriose-Based Interaction between Piriformospora indica and Its Host Arabidopsis. Plant Physiol. 2018;176:2496-2514 pubmed publisher
    ..The wild-type PARN cDNA, expressed under the control of a 35S promoter, complements the mutant phenotype...
  13. Pan Y, Liang X, Niu L, Wang Y, Tong X, Hua H, et al. Comparative studies of pharmacokinetics and anticoagulatory effect in rats after oral administration of Frankincense and its processed products. J Ethnopharmacol. 2015;172:118-23 pubmed publisher
    ..effect, SD rats were randomly divided into six groups, including control, acute cold blood-stasis model, Fu-fang-dan-shen tablet- (0.75g/kg), FRA-, SFF-, and VPF-treated (2.7g/kg) groups, respectively...
  14. Amin Z, Jayalie V, Rajabto W. Recent Management of Patients with Advanced Epidermal Growth Factor Receptor Mutation Non-small Cell Lung Cancer: Role of Afatinib and Lesson Learned for Developing Countries. Acta Med Indones. 2017;49:79-88 pubmed
    ..and National Health Insurance has covered treatment for cancer, including first generation TKIs, Gefitinib dan erlotinib, for patients with EGFR mutation positive advanced/ metastatic non-small cell lung cancer at Cipto ..
  15. Wakizaka M, Eshima H, Tanaka Y, Shirakawa H, Poole D, Kano Y. In vivo Ca2+ dynamics induced by Ca2+ injection in individual rat skeletal muscle fibers. Physiol Rep. 2017;5: pubmed publisher
    ..0 mmol/L Ca2+ with inhibition of ryanodine receptors (RyR) by dantrolene sodium (DAN), and (3) 2...
  16. Chang C, Shih P, Chen T, Ho W, Yang C. Integrated Therapy Decreases the Mortality of Patients with Polymyositis and Dermatomyositis: A Taiwan-wide Population-Based Retrospective Study. J Ethnopharmacol. 2019;: pubmed publisher
    ..notoginseng), "Bai-Ji" (Bletilla striata), "Chen-Pi" (Citrus reticulata), "Hou-Po" (Magnolia officinalis), and "Dan-Shan" (Salvia miltiorrhiza). Integrated therapy has reduced mortality in patients with PM/DM in Taiwan...
  17. Honjo K, Munakata S, Tashiro Y, Salama Y, Shimazu H, Eiamboonsert S, et al. Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice. FASEB J. 2017;31:2625-2637 pubmed publisher
    ..Honjo, K., Munakata, S., Tashiro, Y., Salama, Y., Shimazu, H., Eiamboonsert, S., Dhahri, D., Ichimura, A., Dan, T., Miyata, T., Takeda, K., Sakamoto, K., Hattori, K., Heissig, B...
  18. Chen F, Chang C, Wu T, Yang J, Kung Y, Huang Y, et al. Clinical efficacy of Rong-Yang-Jyh-Gan-Tang on patients with chronic hepatitis C: A double-blinded randomized placebo-controlled crossover study. J Ethnopharmacol. 2017;196:1-8 pubmed publisher
    ..We evaluated the efficacy of Rong-Yang-Jyh-Gan-Tang (RYJGT, composed of Long-Dan-Xie-Gan-Tang, Jia-Wei-Xia-Yao-San, Dan-Shen, and Hou-Po) on patients with chronic hepatitis C...
  19. Lu C, Lin L, Tsai T. Determination and pharmacokinetic study of gentiopicroside, geniposide, baicalin, and swertiamarin in Chinese herbal formulae after oral administration in rats by LC-MS/MS. Molecules. 2014;19:21560-78 pubmed publisher
    ..pharmacokinetics of herbal medicine after the administration of a traditional Chinese herbal prescription of Long-Dan-Xie-Gan-Tang (10 g/kg, p.o.)...
  20. Li Z, Hu Y, Zheng C, Su Q, An C, Luo X, et al. Rules of meridians and acupoints selection in treatment of Parkinson's disease based on data mining techniques. Chin J Integr Med. 2018;: pubmed publisher
    ..Superior-inferior acupoints matching was utilized the most. As to involved meridians, Du Meridian, Dan (Gallbladder) Meridian, Dachang (Large Intestine) Meridian, and Gan (Liver) Meridian were the most popular ..
  21. Gong X, Tong Q, Chen Z, Zhang Y, Xu C, Jin Z. Microvascular density and vascular endothelial growth factor and osteopontin expression during the implantation window in a controlled ovarian hyperstimulation rat model. Exp Ther Med. 2015;9:773-779 pubmed
    ..of COH on implantation biology and pregnancy outcome, and to explore the potential therapeutic role of the TCM Zi Dan Yin (ZDY). Female Sprague Dawley rats were divided into four groups: Control, COH, ZDY and COH + ZDY...
  22. Fok W, Shukla S, Vessoni A, Brenner K, Parker R, Sturgeon C, et al. Posttranscriptional modulation of TERC by PAPD5 inhibition rescues hematopoietic development in dyskeratosis congenita. Blood. 2019;: pubmed publisher
    ..the telomerase RNA component, cause dyskeratosis congenita (DC) in patients harboring mutations in TERC, PARN, NOP10, NHP2, NAF1, or DKC1...
  23. Deleuze C, De Pauw E, Quinton L. Selective reduction of C=C double bonds in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of microcystins. Eur J Mass Spectrom (Chichester). 2010;16:91-9 pubmed publisher
    ..The methodology relies on the reductive properties of the matrix 1,5-diaminonaphtalene (1,5-DAN) which appears to be able to selectively reduce the double carbon-carbon bond belonging to the seventh amino acid...
  24. Fuenzalida M, Cobs V. [Analysis of the territorial patterns of the life contexts of children up to 6 years of age and their potential influence on the coverage of immunization programs in Chile]. Salud Colect. 2018;14:93-107 pubmed publisher
    ..contempla tres fases: la primera, corresponde a la operacionalización de veinte variables socioterritoriales, que dan cuenta de los contextos generales de vida de la población objetivo; la segunda, refiere a la definición de una ..
  25. Sanli H, Akay B, Soydan E, Kocyigit P, Arat M, Ilhan O. Clinical Aspects Of Sclerodermatous Type Graft-Versus-Host Disease After Allogeneic Hematopoietic Cell Transplantation. Turk J Haematol. 2010;27:91-8 pubmed publisher
    ..Olgular?n 8’i likenoid GVHH’dan sklerodermatoz GVHH’ye dönü?ürken, 2’sinde her iki faz bir arada ve 12’sinde sklerodermatoz GVHH denovo ..
  26. Courtois E, Cimerman P, Dubuche V, Goiset M, Orfèvre C, Lagarde A, et al. The burden of venipuncture pain in neonatal intensive care units: EPIPPAIN 2, a prospective observational study. Int J Nurs Stud. 2016;57:48-59 pubmed publisher
    ..Data on all venipunctures, their pain score assessed with the DAN scale and their corresponding analgesic therapies were prospectively collected...
  27. Tolosa E, Botta Orfila T, Morató X, Calatayud C, Ferrer Lorente R, Marti M, et al. MicroRNA alterations in iPSC-derived dopaminergic neurons from Parkinson disease patients. Neurobiol Aging. 2018;69:283-291 pubmed publisher
    ..We performed an explorative genome-wide study of miRNA expression levels in dopaminergic neurons (DAn) from PD patients generated by somatic cell reprogramming and induced pluripotent stem cells differentiation...
  28. Hatami Bavarsad Z, Hemati K, Sayehmiri K, Asadollahi P, Abangah G, Azizi M, et al. Effects of breast milk on pain severity during muscular injection of hepatitis B vaccine in neonates in a teaching hospital in Iran. Arch Pediatr. 2018;25:365-370 pubmed publisher
    ..The severity and duration of pain were compared among all groups during and after injection using the DAN scoring method (evaluation behavioral scale of acute pain in newborn infant)...
  29. Erdem M, Tufekci O, Yilmaz S, Alacacioglu I, Oren H. Long-Term Follow-Up of a Case with Dyskeratosis Congenita Caused by NHP2-V126M/X154R Mutation: Genotype-Phenotype Association. Acta Haematol. 2019;141:28-31 pubmed publisher
    ..Gene mutations associated with DC, such as DC1, TERC, TERT, TINF2, NHP2, NOP10, ACD, CTC1, NAF1, PARN, POT1, RTEL1, STN1, and WRAP53, have been identified in about 70% of patients...
  30. Gomez Cambronero J, Fite K, Miller T. How miRs and mRNA deadenylases could post-transcriptionally regulate expression of tumor-promoting protein PLD. Adv Biol Regul. 2018;68:107-119 pubmed publisher
    ..regulation of PLD involving 3'-exonucleases, specifically the deadenylase, Poly(A)-specific Ribonuclease (PARN), which tags mRNA for mRNA for degradation...
  31. Chang C, Wu P, Chiang J, Wei Y, Chen F, Chen T, et al. Integrative therapy decreases the risk of lupus nephritis in patients with systemic lupus erythematosus: A population-based retrospective cohort study. J Ethnopharmacol. 2017;196:201-212 pubmed publisher
    ..Mu-Dan-Pi" (Paeonia suffruticosa Andr.), "Dan-Shan" (Salvia miltiorrhiza Bge.), "Zhi-Bo-Di-Huang-Wan...
  32. Kuru D, Tarkan Argüden Y, Ar M, Çırakoğlu A, Ongoren S, Yilmaz S, et al. Variant Philadelphia translocations with different breakpoints in six chronic myeloid leukemia patients. Turk J Haematol. 2011;28:186-92 pubmed publisher
    ..AMAÇ: t(9;22)(q34;q11) sonucu olu?an Philadelphia (Ph) kromozomu, kronik miyeloid lösemi (KML) olgular?n?n %90’ dan fazlas?nda gözlenir. KML hastalar?n?n %5-10 unda varyant Ph translokasyonlar? bulunur...
  33. Manosroi J, Chankhampan C, Kumguan K, Manosroi W, Manosroi A. In vitro anti-aging activities of extracts from leaves of Ma Kiang (Cleistocalyx nervosum var. paniala). Pharm Biol. 2015;53:862-9 pubmed publisher
    Cleistocalyx nervosum (DC.) Kosterm. var. paniala (Roxb.) J. Parn. & Chantaran. (Myrtaceae) or Ma Kiang contains high amounts of phenolic compounds. Antioxidant activity of its fruit and seed has been investigated...
  34. Trost M, Blattner A, Léo S, Lehner C. Drosophila dany is essential for transcriptional control and nuclear architecture in spermatocytes. Development. 2016;143:2664-76 pubmed publisher
    ..Like dan and danr, its primordial relatives with functions in somatic tissues, dany encodes a nuclear Psq domain protein...
  35. Huang S, Agrawal D, Wu F, Tsay H. In vitro propagation of Gentiana scabra Bunge - an important medicinal plant in the Chinese system of medicines. Bot Stud. 2014;55:56 pubmed publisher
    Gentiana scabra Bunge commonly known as 'Long dan cao' in China has been used in traditional Chinese medicines for more than 2000 years...
  36. Monecke T, Schell S, Dickmanns A, Ficner R. Crystal structure of the RRM domain of poly(A)-specific ribonuclease reveals a novel m(7)G-cap-binding mode. J Mol Biol. 2008;382:827-34 pubmed publisher
    Poly(A)-specific ribonuclease (PARN) is a processive 3'-exoribonuclease involved in the decay of eukaryotic mRNAs...
  37. Futrell R, Stearns L, Everett D, Piantadosi S, Gibson E. A Corpus Investigation of Syntactic Embedding in Pirahã. PLoS ONE. 2016;11:e0145289 pubmed publisher
    ..Here, we present an analysis of a novel corpus of natural Pirahã speech that was originally collected by Dan Everett and Steve Sheldon. We make the corpus freely available for further research...
  38. Westra J, Tu S, Winther S, Nissen L, Vestergaard M, Andersen B, et al. Evaluation of Coronary Artery Stenosis by Quantitative Flow Ratio During Invasive Coronary Angiography: The WIFI II Study (Wire-Free Functional Imaging II). Circ Cardiovasc Imaging. 2018;11:e007107 pubmed publisher
    ..WIFI II was a predefined substudy to the Dan-NICAD study (Danish Study of Non-Invasive Diagnostic Testing in Coronary Artery Disease), referring 362 consecutive ..
  39. Chen G, Li Y, Gao H, Chen Y, Li X, Li J, et al. New azaphilones and chlorinated phenolic glycosides from Chaetomium elatum with caspase-3 inhibitory activity. Planta Med. 2012;78:1683-9 pubmed publisher
    ..In addition, compounds 1-3 showed inhibitory activity in the cysteine aspartyl-specific protease-3 (caspase-3) enzymatic assay, with IC?? values of 20.6, 10.9, and 7.9?µM, respectively. ..
  40. Boulicault J, Alves S, Cole R. Negative Ion MALDI Mass Spectrometry of Polyoxometalates (POMs): Mechanism of Singly Charged Anion Formation and Chemical Properties Evaluation. J Am Soc Mass Spectrom. 2016;27:1301-13 pubmed publisher
    ..A relative ranking of the ability to induce POM fragmentation is found to be: DAN > CHCA > CNA > DIT> HABA > DCTB > IAA...
  41. Latimer M, Bannister T, Govindjee -. Paul Henry Latimer (1925-2011): discoverer of selective scattering in photosynthetic systems. Photosynth Res. 2017;134:83-91 pubmed publisher
    ..We provide here a glimpse of his personal and professional life, including reminiscences from F. Dudley Bryant, Dan A. Cross, Bobby E. Pyle, Bryan L. Seiber, and Bruce A. Seiber.
  42. Medina Vera I, Serralde Zúñiga A, Islas Ortega L, Jiménez Rolland E, Jimenez Chanes K, Guevara Cruz M. DIAGNOSIS OF METABOLIC SYNDROME IN CHILDREN AS A POTENTIAL INDICATOR OF TECHNICAL ABILITY IN MEDICAL AND NUTRITIONAL CARE. Nutr Hosp. 2015;32:2105-10 pubmed publisher
    ..Conclusión: en el estudio observamos que los profesionales de la salud que dan atención a los pacientes pediátricos no conocen los parámetros y puntos de corte para diagnosticar el SM; ..
  43. Ishikawa H, Yoshikawa H, Izumikawa K, Miura Y, Taoka M, Nobe Y, et al. Poly(A)-specific ribonuclease regulates the processing of small-subunit rRNAs in human cells. Nucleic Acids Res. 2017;45:3437-3447 pubmed publisher
    ..Here, we show that poly(A)-specific ribonuclease (PARN) participates in steps leading to 18S-E maturation in human cells...
  44. Kloppmann W, Negev I, Guttman J, Goren O, Gavrieli I, Guerrot C, et al. Massive arrival of desalinated seawater in a regional urban water cycle: A multi-isotope study (B, S, O, H). Sci Total Environ. 2018;619-620:272-280 pubmed publisher
    ..of reverse osmosis-derived freshwater in the largely engineered water cycle of the greater Tel Aviv region (Dan Region) has profoundly changed previous isotope fingerprints...
  45. Nolan K, Kattamuri C, Rankin S, Read R, Zorn A, Thompson T. Structure of Gremlin-2 in Complex with GDF5 Gives Insight into DAN-Family-Mediated BMP Antagonism. Cell Rep. 2016;16:2077-2086 pubmed publisher
    The DAN family, including Gremlin-1 and Gremlin-2 (Grem1 and Grem2), represents a large family of secreted BMP (bone morphogenetic protein) antagonists. However, how DAN proteins specifically inhibit BMP signaling has remained elusive...
  46. Calvano C, Ventura G, Trotta M, Bianco G, Cataldi T, Palmisano F. Electron-Transfer Secondary Reaction Matrices for MALDI MS Analysis of Bacteriochlorophyll a in Rhodobacter sphaeroides and Its Zinc and Copper Analogue Pigments. J Am Soc Mass Spectrom. 2017;28:125-135 pubmed publisher
    ..2,2':5',2''-terthiophene (TER), anthracene (ANT), and 9,10-diphenylanthracene (DP-ANT), 1,5-diaminonaphthalene (DAN) was found to provide the highest ionization yield with a negligible fragmentation...
  47. Czech B, Hannon G. A Happy 3' Ending to the piRNA Maturation Story. Cell. 2016;164:838-40 pubmed publisher
    ..In this issue of Cell, two studies shed light on this process, identifying conserved PARN-family exonucleases that trim piRNAs to their mature size in silkworms and C. elegans.
  48. Mausner Fainberg K, Kolb H, Penn M, Regev K, Vaknin Dembinsky A, Gadoth A, et al. Differential screening-selected gene aberrative in neuroblastoma (DAN) is increased in the CSF of patients with MS and may be induced by therapy with interferon-β. J Neuroimmunol. 2016;292:93-6 pubmed publisher
    ..Differential screening-selected gene aberrative in neuroblastoma (DAN) is a glycoprotein that antagonizes BMPs...
  49. de Groot J, Hopman I, van Lier M, Branderhorst W, Grimbergen C, den Heeten G. Pressure-standardised mammography does not affect visibility, contrast and sharpness of stable lesions. Eur J Radiol. 2017;86:289-295 pubmed publisher
    ..oil) cysts and lymph nodes that were visible in mammograms obtained in 2009 with a pain-tolerance limited 18 daN target force compression protocol, and in 2014/2015 obtained with a 10kPa (75mmHg) pressure-standardised ..
  50. Rider C, Mulloy B. Heparin, Heparan Sulphate and the TGF-β Cytokine Superfamily. Molecules. 2017;22: pubmed publisher
    ..These vary in structure but seven belong to the CAN or DAN family, which shares the TGF-β type cystine-knot domain...
  51. Gao M, Fritz D, Ford L, Wilusz J. Interaction between a poly(A)-specific ribonuclease and the 5' cap influences mRNA deadenylation rates in vitro. Mol Cell. 2000;5:479-88 pubmed
    ..b>DAN, the major enzyme responsible for poly(A) tail shortening in vitro, specifically interacts with the 5' cap ..
  52. Ong J, Kong D, Chia T, Tandi J, Thomas Yeo B, Chee M. Co-activated yet disconnected-Neural correlates of eye closures when trying to stay awake. Neuroimage. 2015;118:553-62 pubmed publisher
    ..changes, eye closures elicited additional reduction in functional connectivity within nodes of the DMN and DAN, superposed on already reduced connectivity associated with sleep deprivation...
  53. Sarto Jackson I, Tomaska L. How to bake a brain: yeast as a model neuron. Curr Genet. 2016;62:347-70 pubmed publisher
    More than 30 years ago Dan Koshland published an inspirational essay presenting the bacterium as a model neuron (Koshland, Trends Neurosci 6:133-137, 1983)...
  54. Rohr C, Arora A, Cho I, Katlariwala P, Dimond D, Dewey D, et al. Functional network integration and attention skills in young children. Dev Cogn Neurosci. 2018;30:200-211 pubmed publisher
    ..Visual, auditory, sensorimotor, default mode (DMN), dorsal attention (DAN), ventral attention (VAN), salience, and frontoparietal ICNs were identified via Independent Component Analysis and ..
  55. Gao M, Wilusz C, Peltz S, Wilusz J. A novel mRNA-decapping activity in HeLa cytoplasmic extracts is regulated by AU-rich elements. EMBO J. 2001;20:1134-43 pubmed
    ..addition of (7me)GpppG, which specifically sequesters cap-binding proteins such as eIF4E and the deadenylase DAN/PARN. Similar to in vivo observations, the presence of a poly(A) tail represses decapping of RNAs in vitro in a poly(A)-..
  56. Lejeune F, Li X, Maquat L. Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. Mol Cell. 2003;12:675-87 pubmed
    ..Downregulating poly(A) ribonuclease (PARN) also increases the abundance of nonsense-containing mRNAs...
  57. Yin L, Wang Y, Fan L, Xu Y, Wang W, Liu Y, et al. Efficacy of acupuncture for chronic asthma: study protocol for a randomized controlled trial. Trials. 2015;16:424 pubmed publisher
    ..Men), BL13 (Fei Shu) and acupoints used in the sham acupuncture group are DU08 (Jin Suo), BL18 (Gan Shu), BL19 (Dan Shu)...
  58. Troop Gordon W. Peer victimization in adolescence: The nature, progression, and consequences of being bullied within a developmental context. J Adolesc. 2017;55:116-128 pubmed publisher
    Since Dan Olweus's seminal work on bullying in the 1970's (Olweus, 1978), there has been a concerted effort by investigators to identify the confluence of factors that contribute to peer victimization and its role in psychosocial ..
  59. Yao M, Gao W, Tao H, Yang J, Huang T. The regulation effects of danofloxacin on pig immune stress induced by LPS. Res Vet Sci. 2017;110:65-71 pubmed publisher
    Danofloxacin (DAN) is one of the Fluoroquinolone drugs (FQs) that has been widely used in the control and prevention of bacterial infectious disease in animal production...
  60. Mienis O, Arye G. Long-term nitrogen behavior under treated wastewater infiltration basins in a soil-aquifer treatment (SAT) system. Water Res. 2018;134:192-199 pubmed publisher
    ..long term behavior of total nitrogen and its components was investigated in a soil aquifer treatment system of the Dan Region Reclamation Project (Shafdan), Tel-Aviv, Israel...
  61. Wu Y, Ai Y, Wang F, Ma W, Bian Q, Lee D, et al. Simultaneous determination of four secoiridoid and iridoid glycosides in rat plasma by ultra performance liquid chromatography-tandem mass spectrometry and its application to a comparative pharmacokinetic study. Biomed Chromatogr. 2016;30:97-104 pubmed publisher
    ..of four analytes in rat plasma between normal and arthritic rats after oral administration of Huo Luo Xiao Ling Dan and Gentiana macrophylla extract, respectively...
  62. Mulloy B, Rider C. The Bone Morphogenetic Proteins and Their Antagonists. Vitam Horm. 2015;99:63-90 pubmed publisher
    ..including Noggin, Follistatin, Chordin, Twisted gastrulation (TSG), and the seven members of the Cerberus and Dan family...
  63. Meng Q, Zhang J, Zhang Z, Wu T. Geochemistry of dissolved trace elements and heavy metals in the Dan River Drainage (China): distribution, sources, and water quality assessment. Environ Sci Pollut Res Int. 2016;23:8091-103 pubmed publisher
    Dissolved trace elements and heavy metals in the Dan River drainage basin, which is the drinking water source area of South-to-North Water Transfer Project (China), affect large numbers of people and should therefore be carefully ..
  64. Liang L, Yang X, Yu Y, Li X, Wu Y, Shi R, et al. Babao Dan attenuates hepatic fibrosis by inhibiting hepatic stellate cells activation and proliferation via TLR4 signaling pathway. Oncotarget. 2016;7:82554-82566 pubmed publisher
    Babao Dan (BBD), a traditional Chinese medicine, has been widely used as a complementary and alternative medicine to treat chronic liver diseases...
  65. Hacker C, Snyder A, Pahwa M, Corbetta M, Leuthardt E. Frequency-specific electrophysiologic correlates of resting state fMRI networks. Neuroimage. 2017;149:446-457 pubmed publisher
    ..and includes the visual, auditory, and sensorimotor (SMN) networks as well as the dorsal attention network (DAN), which controls spatial attention...
  66. Fajardo Gutierrez A. [Measurement in epidemiology: prevalence, incidence, risk, impact measures]. Rev Alerg Mex. 2017;64:109-120 pubmed
    ..describen los tres principales grupos de medidas en epidemiología: frecuencia, asociación e impacto potencial; se dan ejemplos y se indica cómo deben calcularse...
  67. Burris A, Ballew B, Kentosh J, Turner C, Norton S, Giri N, et al. Hoyeraal-Hreidarsson Syndrome due to PARN Mutations: Fourteen Years of Follow-Up. Pediatr Neurol. 2016;56:62-68.e1 pubmed publisher
    ..Germline mutations in DKC1, TERT, TINF2, RTEL1, ACD, or PARN cause about 60% of individuals with Hoyeraal-Hreidarsson syndrome...
  68. Kurth S, Majerus S, Bastin C, Collette F, Jaspar M, Bahri M, et al. Effects of aging on task- and stimulus-related cerebral attention networks. Neurobiol Aging. 2016;44:85-95 pubmed publisher
    Interactions between a dorsal attention network (DAN) and a ventral attention cerebral network (VAN) have been reported in young participants during attention or short-term memory (STM) tasks...
  69. Fakhari A, Jalilian A, Yousefnia H, Shanehsazzadeh S, Samani A, Daha F, et al. Preparation, Biological Evaluation and Dosimetry Studies of 175Yb-Bis-Phosphonates for Palliative Treatment of Bone Pain. Mol Imaging Radionucl Ther. 2015;24:110-9 pubmed publisher
    ..Sonuç: Hesaplamalara göre, 175?b-ALN’nin için toplam vücut dozu (özellikle böbreklerde) 175?b-PAM’dan %40 daha yüksektir...
  70. Zhang L, Dai F, Cui L, Zhou B, Guo Y. Up-regulation of the active form of small GTPase Rab13 promotes macroautophagy in vascular endothelial cells. Biochim Biophys Acta Mol Cell Res. 2017;1864:613-624 pubmed publisher
    ..as a tool to induce VEC autophagy and identified the differentially expressed genes using high-throughput DAN microarray...
  71. Diouf L, Magwanga R, Gong W, He S, Pan Z, Jia Y, et al. QTL Mapping of Fiber Quality and Yield-Related Traits in an Intra-Specific Upland Cotton Using Genotype by Sequencing (GBS). Int J Mol Sci. 2018;19: pubmed publisher
    ..from an intra-specific cross between two upland cotton accessions, CCRI35 a high fiber quality as female and Nan Dan Ba Di Da Hua (NH), with good yield properties as male parent. The map spanned 4768...
  72. Lippmann J, Lawrence C, Fock A, Jamieson S, Harris R. Provisional report on diving-related fatalities in Australian waters in 2011. Diving Hyperb Med. 2016;46:207-240 pubmed
    ..case review of diving-related deaths reported as occurring in Australia in 2011 was conducted as part of the DAN Asia-Pacific dive fatality reporting project...
  73. Ding X, Ding J, Hua B, Xiong X, Xiao L, Peng F, et al. Abnormal cortical functional activity in patients with ischemic white matter lesions: A resting-state functional magnetic resonance imaging study. Neurosci Lett. 2017;644:10-17 pubmed publisher
    ..to be involved in default mode network (DMN), frontal-parietal control network (FPCN), dorsal attention network (DAN), motor network and right temporal cortex...
  74. Allam W, Ashour M, Waly A, El Khamisy S. Role of Protein Linked DNA Breaks in Cancer. Adv Exp Med Biol. 2017;1007:41-58 pubmed publisher
    ..trapping on the DNA is the mode of action of several anticancer drugs, it lead to formation of protein linked DAN breaks (PDBs)...
  75. Teixeira F, Gago M, Marques P, Moreira P, Magalhães R, Sousa N, et al. Safinamide: a new hope for Parkinson's disease?. Drug Discov Today. 2018;23:736-744 pubmed publisher
    The loss of dopaminergic neurons (DAn) and reduced dopamine (DA) production underlies the reasoning behind the gold standard treatment for Parkinson's disease (PD) using levodopa (L-DOPA)...
  76. Ajadi R, Sobanke O, Adeniyi A, Adeusi A, Adebiyi A, Akinloye A. Influence of Tramadol on Anaesthetic Indices and Physiological Parameters of Epidural Lignocaine in West African Dwarf Sheep Undergoing Laparo-Ovariectomy. Niger J Physiol Sci. 2017;32:165-170 pubmed
    ..and onset of drug action (OAN) (time between epidural injection and loss of pedal reflex), duration of analgesia (DAN) (time between disappearance and reappearance of pedal reflex) were determined...
  77. Tao Y, Huang S, Gu X, Li W, Cai B. Towards the identification of alkaline phosphatase binding ligands in Li-Dan-Hua-Shi pills: A Box-Behnken design optimized affinity selection approach tandem with UHPLC-Q-TOF/MS analysis. J Pharm Biomed Anal. 2018;154:486-491 pubmed publisher
    ..8%) and inter-day (1.3%) precisions. Finally, the adsorbent was successfully applied to identification of binding ligands in Li-Dan-Hua-Shi pills and good recoveries were obtained in the range from 96.9 to 99.4% (RSDs 1.6-3.0%).
  78. Zhang L, Yan Y. Depletion of poly(A)-specific ribonuclease (PARN) inhibits proliferation of human gastric cancer cells by blocking cell cycle progression. Biochim Biophys Acta. 2015;1853:522-34 pubmed publisher
    ..In this research, we found that poly(A)-specific ribonuclease (PARN) was upregulated in gastric tumor tissues and gastric cancer cell lines MKN28 and AGS...
  79. Verduyn M, Rigaud M, Dromer C. [A rare familial form of idiopathic pulmonary fibrosis with Poly(A)-specific ribonuclease (PARN) mutation]. Rev Pneumol Clin. 2017;73:272-275 pubmed publisher
    ..Among them, the PARN (Poly[A]-specific ribonuclease) mutation...
  80. Greenwood P, Blumberg E, Scheldrup M. Hypothesis for cognitive effects of transcranial direct current stimulation: Externally- and internally-directed cognition. Neurosci Biobehav Rev. 2018;86:226-238 pubmed publisher
    ..We further hypothesized that tDCS to the dorsal attention network (DAN) increases processing of external events at the expense of goals and stored information...
  81. Niedzwiecka A, Lekka M, Nilsson P, Virtanen A. Global architecture of human poly(A)-specific ribonuclease by atomic force microscopy in liquid and dynamic light scattering. Biophys Chem. 2011;158:141-9 pubmed publisher
    ..Poly(A)-specific ribonuclease (PARN) is a eukaryotic enzyme that efficiently degrades mRNA poly(A) tails...
  82. Stuart B, Choi J, Zaidi S, Xing C, Holohan B, Chen R, et al. Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening. Nat Genet. 2015;47:512-7 pubmed publisher
    ..Gene burden analysis comparing 78 European cases and 2,816 controls implicated PARN, an exoribonuclease with no previous connection to telomere biology or disease, with five new heterozygous damaging ..
  83. Maragozidis P, Papanastasi E, Scutelnic D, Totomi A, Kokkori I, Zarogiannis S, et al. Poly(A)-specific ribonuclease and Nocturnin in squamous cell lung cancer: prognostic value and impact on gene expression. Mol Cancer. 2015;14:187 pubmed publisher
    ..Quantitative real-time PCR showed that four deadenylases, PARN, CNOT6, CNOT7 and NOC, are differentially expressed in our SCC clinical samples...
  84. Westlye L, Kaufmann T, Alnæs D, Hullstein I, Bjørnebekk A. Brain connectivity aberrations in anabolic-androgenic steroid users. Neuroimage Clin. 2017;13:62-69 pubmed
    ..reduced connectivity between the amygdala and default-mode network (DMN) and between the dorsal attention network (DAN) and a frontal node encompassing the superior and inferior frontal gyri (SFG/IFG) and the anterior cingulate cortex ..
  85. Fan J, Bao Y, Meng X, Wang S, Li T. [Study on relationship between efficacy against lung cancer and different parts of Schizonepeta tenuifolia based on microfluidic chip technology]. Zhongguo Zhong Yao Za Zhi. 2017;42:1717-1721 pubmed publisher
    ..2, 6 and 15th are the luteolin, icynaroside, rosmarinic, caffeic acid, and hesperidin, while the 20 and 10th may be dan phenolic acid L and benzoic acid...
  86. Hawasli A, Rutlin J, Roland J, Murphy R, Song S, Leuthardt E, et al. Spinal Cord Injury Disrupts Resting-State Networks in the Human Brain. J Neurotrauma. 2017;: pubmed publisher
    ..Seed-based correlation mapping was performed using five RSNs: default-mode (DMN), dorsal-attention (DAN) , salience (SAL), control (CON) and somatomotor (SMN)...
  87. Kobaisi M, Bhosale R, El Khouly M, La D, Padghan S, Bhosale S, et al. The sensitivity of donor - acceptor charge transfer to molecular geometry in DAN - NDI based supramolecular flower-like self-assemblies. Sci Rep. 2017;7:16501 pubmed publisher
    ..self-assembled from an electron acceptor (NDI-EA: naphthalene diimide with appended diamine) and an electron donor (DAN: phosphonic acid-appended dialkoxynapthalene) in aqueous medium...
  88. Shi W, Zhao J, Anderson K, Warburton D. Gremlin negatively modulates BMP-4 induction of embryonic mouse lung branching morphogenesis. Am J Physiol Lung Cell Mol Physiol. 2001;280:L1030-9 pubmed
    ..Here, we studied the BMP-4 antagonist Gremlin, which is a member of the DAN family of BMP antagonists that can bind and block BMP-2/4 activity...
  89. Tibaek S, Gard G, Dehlendorff C, Iversen H, Biering Soerensen F, Jensen R. Lower Urinary Tract Symptoms, Erectile Dysfunction, and Quality of Life in Poststroke Men: A Controlled Cross-Sectional Study. Am J Mens Health. 2017;11:748-756 pubmed publisher
    ..Participants filled in the Danish Prostate Symptom Score (DAN-PSS-1) Questionnaire, the International Index of Erectile Function (IIEF-5), the 36-Item Short Form (SF-36), the ..
  90. Šelešovská R, Martinková P, Štěpánková M, Navratil T, Chýlková J. Comparison Study of Voltammetric Behavior of Muscle Relaxant Dantrolene Sodium on Silver Solid Amalgam and Bismuth Film Electrodes. J Anal Methods Chem. 2017;2017:3627428 pubmed publisher
    Voltammetric behavior of muscle relaxant dantrolene sodium (DAN) was studied and the voltammetric methods for its determination using polished and mercury meniscus modified silver solid amalgam electrodes (p-AgSAE and m-AgSAE) as well as ..
  91. Li S, Wu Q, Yin D, Feng C, Liu Z, Wang L. Phytochemical variation among the traditional Chinese medicine Mu Dan Pi from Paeonia suffruticosa (tree peony). Phytochemistry. 2018;146:16-24 pubmed publisher
    Mu Dan Pi is a traditional Chinese medicine used to treat inflammation, cancer, allergies, diabetes, angiocardiopathy, and neurodegenerative diseases...