PARD3

Summary

Gene Symbol: PARD3
Description: par-3 family cell polarity regulator
Alias: ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2, partitioning defective 3 homolog, CTCL tumor antigen se2-5, PAR3-alpha, atypical PKC isotype-specific interacting protein, bazooka, par-3 family cell polarity regulator alpha, par-3 partitioning defective 3 homolog, protein phosphatase 1, regulatory subunit 118
Species: human
Products:     PARD3

Top Publications

  1. Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H. PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions. Biochem Biophys Res Commun. 2002;299:641-6 pubmed
    ..The encoded protein of 1,205 amino acids contains a region homologous to the aPKC-binding domain of PAR3alpha, another human homologue previously identified, and three PDZ domains; the first PDZ domain of PAR3alpha is ..
  2. Chen X, Macara I. Par-3 controls tight junction assembly through the Rac exchange factor Tiam1. Nat Cell Biol. 2005;7:262-9 pubmed
    ..These results define a critical function for Par-3 in tight junction assembly, and reveal a novel mechanism through which Par-3 engages in the spatial regulation of Rac activity and establishment of epithelial polarity. ..
  3. Zen K, Yasui K, Gen Y, Dohi O, Wakabayashi N, Mitsufuji S, et al. Defective expression of polarity protein PAR-3 gene (PARD3) in esophageal squamous cell carcinoma. Oncogene. 2009;28:2910-8 pubmed publisher
    ..carcinoma (ESCC) cell lines using a high-density oligonucleotide microarray and found a homozygous deletion of PARD3 (the gene encoding PAR-3)...
  4. Lampugnani M, Orsenigo F, Rudini N, Maddaluno L, Boulday G, Chapon F, et al. CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J Cell Sci. 2010;123:1073-80 pubmed publisher
    ..VEC co-distributes with members of the Par polarity complex (Par3 and PKCzeta) and is needed for activation of PKCzeta...
  5. Fang C, Xu Y. Down-regulated expression of atypical PKC-binding domain deleted asip isoforms in human hepatocellular carcinomas. Cell Res. 2001;11:223-9 pubmed
    Asip is a mammalian homologue of polarity protein Par-3 of Caenorhabditis elegans and Bazooka of Drosophila melanogaster...
  6. Koh W, Mahan R, Davis G. Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling. J Cell Sci. 2008;121:989-1001 pubmed publisher
    ..3D) collagen matrices and that their regulation is mediated by various downstream effectors, including Pak2, Pak4, Par3 and Par6...
  7. McCaffrey L, Montalbano J, Mihai C, Macara I. Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis. Cancer Cell. 2012;22:601-14 pubmed publisher
    ..To address this issue, we depleted the Par3 polarity gene by RNAi in combination with oncogenic Notch or Ras(61L) expression in the murine mammary gland...
  8. Joberty G, Petersen C, Gao L, Macara I. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol. 2000;2:531-9 pubmed
    ..This assembly is implicated in the formation of normal tight junctions at epithelial cell-cell contacts. Thus, Par6 is a key adaptor that links Cdc42 and atypical PKCs to Par3.
  9. Suzuki A, Yamanaka T, Hirose T, Manabe N, Mizuno K, Shimizu M, et al. Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures. J Cell Biol. 2001;152:1183-96 pubmed
    ..Together with the fact that aPKC and a mammalian PAR-3 homologue, aPKC-specific interacting protein (ASIP), colocalize at the tight junctions of polarized epithelial cells (Izumi, Y., H. Hirose, Y. Tamai, S.-I. Hirai, Y...

More Information

Publications115 found, 100 shown here

  1. Nishimura T, Yamaguchi T, Kato K, Yoshizawa M, Nabeshima Y, Ohno S, et al. PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nat Cell Biol. 2005;7:270-7 pubmed
    ..We propose that the PAR-6-PAR-3 complex mediates Cdc42-induced Rac activation by means of STEF/Tiam1, and that this process seems to be required for the establishment of neuronal polarity. ..
  2. Wang Y, Du D, Fang L, Yang G, Zhang C, Zeng R, et al. Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling. EMBO J. 2006;25:5058-70 pubmed
    The conserved polarity complex, comprising the partitioning-defective (Par) proteins Par3 and Par6, and the atypical protein kinase C, functions in various cell-polarization events and asymmetric cell divisions...
  3. Xue B, Krishnamurthy K, Allred D, Muthuswamy S. Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion. Nat Cell Biol. 2013;15:189-200 pubmed publisher
    ..We report that partitioning defective protein 3 (Par3) is dysregulated in metastasis in human breast cancer, and is associated with a higher tumour grade and ErbB2-..
  4. Wells C, Fawcett J, Traweger A, Yamanaka Y, Goudreault M, Elder K, et al. A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. Cell. 2006;125:535-48 pubmed
    ..We propose that Rich1 and Amot maintain TJ integrity by the coordinate regulation of Cdc42 and by linking specific components of the TJ to intracellular protein trafficking. ..
  5. Iden S, Rehder D, August B, Suzuki A, Wolburg Buchholz K, Wolburg H, et al. A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells. EMBO Rep. 2006;7:1239-46 pubmed
    ..They also point to a direct role of a cadherin in the regulation of cell polarity in vertebrates. ..
  6. Gao L, Macara I, Joberty G. Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties. Gene. 2002;294:99-107 pubmed
    The partitioning-defective 3 (par3) gene encodes a protein with three postsynaptic density90/DiscslargeA/ZO-1 (PDZ) domains that is required for cell polarity establishment in metazoans...
  7. Kunnev D, Ivanov I, Ionov Y. Par-3 partitioning defective 3 homolog (C. elegans) and androgen-induced prostate proliferative shutoff associated protein genes are mutationally inactivated in prostate cancer cells. BMC Cancer. 2009;9:318 pubmed publisher
    ..Sequencing identified inactivating mutations in both alleles of the PARD3 and AS3 genes in the LNCaP and 22RV1 cells, respectively...
  8. Ito K, Bahry M, Hui Y, Furuse M, Chowdhury V. Acute heat stress up-regulates neuropeptide Y precursor mRNA expression and alters brain and plasma concentrations of free amino acids in chicks. Comp Biochem Physiol A Mol Integr Physiol. 2015;187:13-9 pubmed publisher
    ..HT also increased the expression of neuropeptide Y (NPY) and agouti-signaling protein (ASIP) precursor mRNA, while no change was observed in pro-opiomelanocortin, cholecystokinin, ghrelin, or corticotropin-..
  9. Girczys Połedniok K, Pudlo R, Jarzab M, Szymlak A. [Cocaine - Characteristics and addiction]. Med Pr. 2016;67:537-44 pubmed publisher
    ..Przegl?du literatury dokonano, u?ywaj?c baz bibliograficznych Medline, PubMed i Polskiej Bibliografii Lekarskiej oraz zasobów Biblioteki ?l?skiej...
  10. Haddad N, Mahmud Batainh A, Suleiman Migdadi O, Saini D, Krishnamurthy V, Parameswaran S, et al. Next generation sequencing of Apis mellifera syriaca identifies genes for Varroa resistance and beneficial bee keeping traits. Insect Sci. 2016;23:579-90 pubmed publisher
    ..We have identified immune related embryonic development (Cactus, Relish, dorsal, Ank2, baz), Varroa hygiene (NorpA2, Zasp, LanA, gasp, impl3) and Varroa resistance (Pug, pcmt, elk, elf3-s10, Dscam2, Dhc64C, ..
  11. Lee S, Stewart C, Schulze K, Cole R, Wu L, Yager J, et al. The Plasma Proteome Is Associated with Anthropometric Status of Undernourished Nepalese School-Aged Children. J Nutr. 2017;147:304-313 pubmed publisher
    ..b>Results: Among 982 proteins, 1, 10, 14, and 17 proteins were associated with BAZ, HAZ, MUAC, and AMA, respectively (q < 0.05)...
  12. Fine D, Flusser H, Markus B, Shorer Z, Gradstein L, Khateeb S, et al. A syndrome of congenital microcephaly, intellectual disability and dysmorphism with a homozygous mutation in FRMD4A. Eur J Hum Genet. 2015;23:1729-34 pubmed publisher
    ..regulates cell polarity by playing an important role in the activation of ARF6, mediating the interaction between Par3 and the ARF6 guanine nucleotide exchange factor...
  13. Noguchi N, Hirose T, Suzuki T, Kagaya M, Chida K, Ohno S, et al. Atypical protein kinase C isoforms differentially regulate directional keratinocyte migration during wound healing. J Dermatol Sci. 2019;93:101-108 pubmed publisher
    ..Atypical protein kinase C (aPKC) isoforms aPKCζ and aPKCλ form a ternary complex with Par3 and Par6, and play crucial roles in establishing and maintaining epithelial cell polarity...
  14. Jarrett S, Wolf Horrell E, Boulanger M, D Orazio J. Defining the Contribution of MC1R Physiological Ligands to ATR Phosphorylation at Ser435, a Predictor of DNA Repair in Melanocytes. J Invest Dermatol. 2015;135:3086-3095 pubmed publisher
    ..In contrast, MC1R antagonists agouti signaling protein (ASIP) or human β-defensin 3 (HBD3) interfere with ATR-pS435 generation, impair the XPA-DNA interaction, and reduce DNA ..
  15. Healy L, Puy C, Fernandez J, Mitrugno A, Keshari R, Taku N, et al. Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo. J Biol Chem. 2017;292:8616-8629 pubmed publisher
    ..antibodies against the neutrophil receptors endothelial protein C receptor (EPCR), protease-activated receptor 3 (PAR3), and macrophage-1 antigen (Mac-1) blocked APC inhibition of NETosis...
  16. Ellery P, Maroney S, Cooley B, Luyendyk J, Zogg M, Weiler H, et al. A balance between TFPI and thrombin-mediated platelet activation is required for murine embryonic development. Blood. 2015;125:4078-84 pubmed publisher
    ..mice lacking the platelet thrombin receptor, protease activated receptor 4 (PAR4; Par4(-/-)), or its coreceptor, PAR3, were mated...
  17. Heuberger D, Franchini A, Madon J, Schuepbach R. Thrombin cleaves and activates the protease-activated receptor 2 dependent on thrombomodulin co-receptor availability. Thromb Res. 2019;177:91-101 pubmed publisher
    ..In mammals, three of the four PARs (PAR1, PAR3, and PAR4) that are expressed respond to the prototypical procoagulant enzyme thrombin, whereas PAR2 was assumed to ..
  18. Poh B, Wong J, Norimah A, Deurenberg P. Differences in Body Build in Children of Different Ethnic Groups and their Impact on the Prevalence of Stunting, Thinness, Overweight, and Obesity. Food Nutr Bull. 2016;37:3-13 pubmed publisher
    ..Z scores for height-for-age (HAZ) and body mass index-for-age (BAZ) were calculated using the World Health Organization (WHO) 2007 growth standards...
  19. Garemo M, Elamin A, Gardner A. Weight status and food habits of preschool children in Abu Dhabi, United Arab Emirates: NOPLAS project. Asia Pac J Clin Nutr. 2018;27:1302-1314 pubmed publisher
    ..Z scores for height-for-age (HAZ), weight-for-age (WAZ), and BMI-for-age (BAZ) were calculated based on WHO protocols...
  20. Wang Y, Zhao Z, Rege S, Wang M, Si G, Zhou Y, et al. 3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice. Nat Med. 2016;22:1050-5 pubmed publisher
    ..mediated by the activation of protease-activated receptor 1 (F2R, also known as PAR1) and F2RL1 (also known as PAR3) via noncanonical cleavage...
  21. Forteza R, Figueroa Y, Mashukova A, Dulam V, SALAS P. Conditional knockout of polarity complex (atypical) PKC? reveals an anti-inflammatory function mediated by NF-?B. Mol Biol Cell. 2016;27:2186-97 pubmed publisher
    The conserved proteins of the polarity complex made up of atypical PKC (aPKC, isoforms ? and ?), Par6, and Par3 determine asymmetry in several cell types, from Caenorhabditis elegans oocytes to vertebrate epithelia and neurons...
  22. Jonnalagadda M, Norton H, Ozarkar S, Kulkarni S, Ashma R. Association of genetic variants with skin pigmentation phenotype among populations of west Maharashtra, India. Am J Hum Biol. 2016;28:610-8 pubmed publisher
    ..SNPs) known to play a role in pigmentation (rs1426654-SLC24A5, rs1042602-TYR, rs16891982-SLC45A2, rs6058017-ASIP, and rs642742-KITLG) and MI measures were tested using standard one-way analysis of variance (ANOVA) within each ..
  23. Deng Y, Xiong F, Wu M, Yang F. [A follow-up on first-year growth and development of 61 very low birth weight preterm infants]. Zhongguo Dang Dai Er Ke Za Zhi. 2016;18:482-7 pubmed
    ..The peaks of body mass index-for-age Z-score (BAZ) and WHZ appeared at 1 month of corrected age...
  24. Jedrusik A, Bruce A, Tan M, Leong D, Skamagki M, Yao M, et al. Maternally and zygotically provided Cdx2 have novel and critical roles for early development of the mouse embryo. Dev Biol. 2010;344:66-78 pubmed publisher
    ..with defects in cell polarisation, reflected by expression and localisation of cell polarity molecules such as Par3 and aPKC and cell compaction at the 8- and 16-cell stages...
  25. Ma L, Shi B, Zheng Q. Cell Polarity and PAR Complex Likely to Be Involved in Dexamethasone-Induced Cleft Palate. J Craniofac Surg. 2017;: pubmed publisher
    ..staining, western blot, and real-time polymerase chain reaction were performed to detect the expression of PAR3/PAR6/aPKC...
  26. Ross A, Papier K, Luceres Catubig R, Chau T, Inobaya M, Ng S. Poverty, Dietary Intake, Intestinal Parasites, and Nutritional Status among School-Age Children in the Rural Philippines. Trop Med Infect Dis. 2017;2: pubmed publisher
    ..7% polyparasitism). There was a decreasing trend between infection intensity and the mean values of HAZ and BAZ identified for T. trichiura or hookworm infections. Stunted children were more likely to be male (AOR = 1...
  27. Peng X, Gao S, Deng H, Cai H, Zhou Z, Xiang R, et al. Perturbation of epithelial apicobasal polarity by rhomboid family-1 gene overexpression. FASEB J. 2018;32:5577-5586 pubmed publisher
    ..binds to Par6a, a component of a protein complex consisting of partitioning-defective scaffold protein (Par)6, Par3, renin-angiotensin system-related C3 botulinum toxin substrate (Rac)1, and cell-division cycle (Cdc)42, which is ..
  28. Zuo X, Guo W, Lipschutz J. The exocyst protein Sec10 is necessary for primary ciliogenesis and cystogenesis in vitro. Mol Biol Cell. 2009;20:2522-9 pubmed publisher
    ..Finally, Par3 was recently shown to regulate primary cilia biogenesis...
  29. Eze J, Oguonu T, Ojinnaka N, Ibe B. Physical growth and nutritional status assessment of school children in Enugu, Nigeria. Niger J Clin Pract. 2017;20:64-70 pubmed publisher
    ..6 ± 10.2 cm, 29.7 ± 7.7 kg, 15.7 ± 2.4 kg/m2, respectively. Their mean ± SD scores of the WAZ, HAZ, and BAZ were 0.33 ± 1.20, 0.78 ± 1.17, and - 0.51 ± 1.27, respectively. A majority (78...
  30. Clemente A, Netto B, de Carvalho Ferreira J, da Silveira Campos R, De Piano Ganen A, Tock L, et al. [Waist circumference as a marker for screening nonalcoholic fatty liver disease in obese adolescents]. Rev Paul Pediatr. 2016;34:47-55 pubmed publisher
    ..The NAFLD patients had significantly higher values for body weight, BMI (body mass index), BAZ-score (BMI-for-age z-scores), total fat (% and kg), WC, visceral fat, insulin, insulin resistance index (HOMA-IR), ..
  31. Treviño L, Yang W, French D, Hunger S, Carroll W, Devidas M, et al. Germline genomic variants associated with childhood acute lymphoblastic leukemia. Nat Genet. 2009;41:1001-5 pubmed publisher
    ..86, respectively) and were associated with methotrexate accumulation and gene expression pattern in leukemic lymphoblasts. We conclude that germline variants affect susceptibility to, and characteristics of, specific ALL subtypes. ..
  32. Tep C, Kim M, Opincariu L, Limpert A, Chan J, Appel B, et al. Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein. J Biol Chem. 2012;287:1600-8 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) was shown to play a role in Schwann cell myelination by recruiting Par3 to the axon-glial interface, but the underlying mechanism has remained unclear...
  33. Wang G, Cheng L, Fan R, Irwin D, Tang S, Peng J, et al. Signature of balancing selection at the MC1R gene in Kunming dog populations. PLoS ONE. 2013;8:e55469 pubmed publisher
    ..pathway, and is regulated by three genes in dogs: MC1R (melanocortin receptor 1), CBD103 (β-defensin 103), and ASIP (agouti-signaling protein precursor)...
  34. Zollinger D, Chang K, Baalman K, Kim S, Rasband M. The Polarity Protein Pals1 Regulates Radial Sorting of Axons. J Neurosci. 2015;35:10474-84 pubmed publisher
    ..As in other polarized cells, we found that Pals1 interacts with Par3 and loss of Pals1 reduced levels of Par3 in Schwann cells...
  35. Bulgakova N, Brown N. Drosophila p120-catenin is crucial for endocytosis of the dynamic E-cadherin-Bazooka complex. J Cell Sci. 2016;129:477-82 pubmed publisher
    ..In Drosophila, p120-catenin facilitates endocytosis of the dynamic E-cadherin-Bazooka subcomplex, which is followed by its recycling...
  36. Brinkmann B, Steinbacher T, Hartmann C, Kummer D, Pajonczyk D, Mirzapourshafiyi F, et al. VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation. Mol Biol Cell. 2016;27:2811-21 pubmed publisher
    ..Cell polarity is regulated by highly conserved cell polarity protein complexes such as the Par3-aPKC-Par6 complex and the CRB3-Pals1-PATJ complex, which are expressed by many different cell types and regulate ..
  37. Zhou Y, Fang L, Du D, Zhou W, Feng X, Chen J, et al. Proteome identification of binding-partners interacting with cell polarity protein Par3 in Jurkat cells. Acta Biochim Biophys Sin (Shanghai). 2008;40:729-39 pubmed
    The evolutionarily conserved cell polarity protein Par3, a scaffold-like PDZ-containing protein, plays a critical role in the establishment and maintenance of epithelial cell polarity...
  38. Purttiponthanee S, Rojroongwasinkul N, Wimonpeerapattana W, Thasanasuwan W, Senaprom S, Khouw I, et al. The Effect of Breakfast Type on Total Daily Energy Intake and Body Mass Index Among Thai School Children. Asia Pac J Public Health. 2016;28:85S-93S pubmed publisher
    ..the association between breakfast types consumed, daily energy intake, and body mass index for age Z-score (BAZ). Cross-sectional data from 1258 children aged 7 to 12...
  39. Gluckman T, Mundy N. The differential expression of MC1R regulators in dorsal and ventral quail plumages during embryogenesis: Implications for plumage pattern formation. PLoS ONE. 2017;12:e0174714 pubmed publisher
    ..inhibition-agouti signaling and agouti-related protein (ASIP and AGRP, respectively)...
  40. Selem Solís J, Alcocer Gamboa A, Hattori Hara M, Esteve Lanao J, Larumbe Zabala E. Nutrimetry: BMI assessment as a function of development. Endocrinol Diabetes Nutr. 2018;65:84-91 pubmed publisher
    ..Data crossed were BMI-for-age z-scores (BAZ) with height-for-age z-scores (HAZ) according to the World Health Organization (WHO) standards...
  41. Chen X, Macara I. Par-3 mediates the inhibition of LIM kinase 2 to regulate cofilin phosphorylation and tight junction assembly. J Cell Biol. 2006;172:671-8 pubmed
    ..Our findings identify LIMK2 as a novel target of Par-3 and uncover a molecular mechanism by which Par-3 could regulate actin dynamics during cell polarization. ..
  42. Abu Siniyeh A, Owen D, Benzing C, Rinkwitz S, Becker T, Majumdar A, et al. The aPKC/Par3/Par6 Polarity Complex and Membrane Order Are Functionally Interdependent in Epithelia During Vertebrate Organogenesis. Traffic. 2016;17:66-79 pubmed publisher
    ..Conversely, using morpholino knock down in zebrafish, we found that membrane order was dependent upon the Crb3 and Par3 polarity protein expression in ductal epithelia...
  43. Wang X, Niu Y, Zhou J, Yu H, Kou Q, Lei A, et al. Multiplex gene editing via CRISPR/Cas9 exhibits desirable muscle hypertrophy without detectable off-target effects in sheep. Sci Rep. 2016;6:32271 pubmed publisher
    ..in sheep by co-injecting one-cell-stage embryos with Cas9 mRNA and RNA guides targeting three genes (MSTN, ASIP, and BCO2)...
  44. de la Rosa J, Weber J, Friedrich M, Li Y, Rad L, Ponstingl H, et al. A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes. Nat Genet. 2017;49:730-741 pubmed publisher
    ..We validated ZBTB20, CELF2, PARD3, AKAP13 and WAC, which were identified by our screens in multiple cancer types, as new tumor suppressor genes in ..
  45. Martin S, Cutmore S, Ward S, Cribb T. An updated concept and revised composition for <i>Hamacreadium</i> Linton, 1910 (Opecoelidae: Plagioporinae) clarifies a previously obscured pattern of host-specificity among species. Zootaxa. 2017;4254:151-187 pubmed publisher
    ..comb., Hamacreadium lutiani (Shen, 1990) n. comb., Hamacreadium morgani Baz,1946 and Hamacreadium phyllorchis (Bilqees, 1976) Cribb, 2005...
  46. Zhou P, Xue W, Peng J, Wang Y, Wei L, Yang Z, et al. Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway. J Exp Clin Cancer Res. 2017;36:139 pubmed publisher
    ..Bioinformatics, qRT-PCR, western blot and immunohistochemical (IHC) analyses were used to examine expression of Par3, a key component of polarity-associated partitioning defective (PAR) complex, in primary and metastatic clinical ..
  47. Ke H, Zhao L, Zhang H, Feng X, Xu H, Hao J, et al. Loss of TDP43 inhibits progression of triple-negative breast cancer in coordination with SRSF3. Proc Natl Acad Sci U S A. 2018;115:E3426-E3435 pubmed publisher
    ..The TDP43/SRSF3 complex controls specific splicing events, including downstream genes PAR3 and NUMB The effect of reduced metastasis and proliferation upon the knockdown of TDP43 or SRSF3 is ..
  48. Lan H, Wang Q, Fernandez Gonzalez R, Feng J. A biomechanical model for cell polarization and intercalation during Drosophila germband extension. Phys Biol. 2015;12:056011 pubmed publisher
    ..The model predicts the polarization of Rho-kinase, myosin and Bazooka downstream of an anisotropic Shroom distribution...
  49. van Adrichem A, Wennerberg K. MgcRacGAP inhibition stimulates JAK-dependent STAT3 activity. FEBS Lett. 2015;589:3859-65 pubmed publisher
    ..Finally, we demonstrated that MINC1-induced STAT3 activation likely is due to increased STAT3 phosphorylation caused by a Rac1-PAR3-IL6-IL6R-JAK2 mediated autocrine/paracrine mechanism.
  50. Widodo Y, Sandjaja S, Sumedi E, Khouw I, Deurenberg P. The effect of socio-demographic variables and dairy use on the intake of essential macro- and micronutrients in 0.5-12-year-old Indonesian children. Asia Pac J Clin Nutr. 2016;25:356-67 pubmed publisher
    ..Overall height for age Z-score (HAZ) and body mass index for age Z-score (BAZ) values (mean±SE) were -1.40±0.03 and -0.48±0...
  51. Culurgioni S, Mari S, Bonetti P, Gallini S, Bonetto G, Brennich M, et al. Insc:LGN tetramers promote asymmetric divisions of mammary stem cells. Nat Commun. 2018;9:1025 pubmed publisher
    ..We show that Insc:LGN tetramers constitute stable cores of Par3-Insc-LGN-GαiGDP complexes, which cannot be dissociated by NuMA...
  52. Johansson A, Driessens M, Aspenstrom P. The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1. J Cell Sci. 2000;113 ( Pt 18):3267-75 pubmed
    ..These findings, together with the reported roles of PAR-6 and PAR-3 in C. elegans, suggest that Cdc42 and Rac1 and PAR-6/PAR-3 are involved in the establishment of cell polarity in epithelial cells. ..
  53. Harris T, Peifer M. The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila. J Cell Biol. 2005;170:813-23 pubmed
    ..Adherens junctions (AJs) often direct this polarity, but we previously found that Bazooka (Baz) acts upstream of AJs as epithelial polarity is first established in Drosophila...
  54. Keder A, Rives Quinto N, Aerne B, Franco M, Tapon N, Carmena A. The hippo pathway core cassette regulates asymmetric cell division. Curr Biol. 2015;25:2739-2750 pubmed publisher
    ..The Hippo pathway downstream kinase Warts, LATS1-2 in mammals, associates with the ACD modulators Inscuteable and Bazooka in vivo and phosphorylates Canoe, the ortholog of Afadin/AF-6, in vitro...
  55. Cheng T, Loy S, Toh J, Cheung Y, Chan J, Godfrey K, et al. Predominantly nighttime feeding and weight outcomes in infants. Am J Clin Nutr. 2016;104:380-8 pubmed publisher
    ..Compared with pDT feeding, pNT feeding was associated with a higher BAZ gain from 12 to 24 mo of age (adjusted β = 0.38; 95% CI: 0.11, 0.65; P = 0...
  56. Baumholtz A, Simard A, Nikolopoulou E, Oosenbrug M, Collins M, Piontek A, et al. Claudins are essential for cell shape changes and convergent extension movements during neural tube closure. Dev Biol. 2017;428:25-38 pubmed publisher
    ..However, apical accumulation of Vangl2, RhoA, and pMLC were reduced, and Par3 and Cdc42 were mislocalized at the apical cell surface...
  57. Hänzelmann S, Wang J, Guney E, Tang Y, Zhang E, Axelsson A, et al. Thrombin stimulates insulin secretion via protease-activated receptor-3. Islets. 2015;7:e1118195 pubmed publisher
    ..F2Rl2 is a G-protein-coupled receptor (GPCR) that encodes protease-activated receptor-3 (PAR3)...
  58. Boudreaux M, Barnes S. Comparison of the activation peptide regions of protease-activated receptors (PAR) in members of the Family Felidae. Vet Clin Pathol. 2016;45:400-5 pubmed publisher
    ..and predicted amino acid composition of the activation peptide regions of protease-activated receptors PAR1, PAR3, and PAR4 in Felidae family members...
  59. Jerger S, Damian M, McAlpine R, Abdi H. Visual speech alters the discrimination and identification of non-intact auditory speech in children with hearing loss. Int J Pediatr Otorhinolaryngol. 2017;94:127-137 pubmed publisher
    ..non-intact auditory speech (excised onsets) as, for example, an intact consonant/rhyme in the visual track (Baa or Baz) coupled to non-intact onset/rhyme in the auditory track (/-B/aa or/-B/az)...
  60. Jimeno D, Gómez C, Calzada N, de la Villa P, Lillo C, Santos E. RASGRF2 controls nuclear migration in postnatal retinal cone photoreceptors. J Cell Sci. 2016;129:729-42 pubmed publisher
    ..of signaling molecules known to participate in nuclear migration and cytoskeletal reorganization, such as PAR3, PAR6 and activated, phosphorylated forms of PAK, MLC2 and VASP...
  61. Aguilar Aragon M, Elbediwy A, Foglizzo V, Fletcher G, Li V, Thompson B. Pak1 Kinase Maintains Apical Membrane Identity in Epithelia. Cell Rep. 2018;22:1639-1646 pubmed publisher
    ..of epithelial polarity and morphology, with cells losing markers of apical polarization such as Crumbs, Par3/Bazooka, or ZO-1...
  62. Shin K, Wang Q, Margolis B. PATJ regulates directional migration of mammalian epithelial cells. EMBO Rep. 2007;8:158-64 pubmed
    ..In addition, we found that aPKC and Par3 localize to the leading edge during migration of epithelia and that PATJ regulates their localization...
  63. Coffill C, Muller P, Oh H, Neo S, Hogue K, Cheok C, et al. Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. EMBO Rep. 2012;13:638-44 pubmed publisher
    ..Advanced proteomics has thus allowed the detection of a new mechanism of p53-driven invasion. ..
  64. Chow C, Ebine K, Knab L, Bentrem D, Kumar K, Munshi H. Cancer Cell Invasion in Three-dimensional Collagen Is Regulated Differentially by Gα13 Protein and Discoidin Domain Receptor 1-Par3 Protein Signaling. J Biol Chem. 2016;291:1605-18 pubmed publisher
    ..Knockdown of the polarity protein Par3, which can function downstream of DDR1, also reversed the effects of Gα13 knockdown on cell-cell adhesion and ..
  65. Bazellieres E, Aksenova V, Barthelemy Requin M, Massey Harroche D, Le Bivic A. Role of the Crumbs proteins in ciliogenesis, cell migration and actin organization. Semin Cell Dev Biol. 2018;81:13-20 pubmed publisher
    ..These are the Par complex including aPKC, PAR3 and PAR6 and the Crumbs complex including, CRUMBS, PALS1 and PATJ/MUPP1...
  66. Yeo M, Kim J, Suh K, Kim S, Lee O, Kim K. Decreased Expression of the Polarity Regulatory PAR Complex Predicts Poor Prognosis of the Patients with Colorectal Adenocarcinoma. Transl Oncol. 2018;11:109-115 pubmed publisher
    Partitioning defective (Par) proteins regulate cell polarity and differentiation. Par3, Par6?, and protein kinase C? (PKC?), which are PAR complex members, have been shown to be associated with oncogenesis and progression...
  67. Hidalgo Carcedo C, Hooper S, Chaudhry S, Williamson P, Harrington K, Leitinger B, et al. Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6. Nat Cell Biol. 2011;13:49-58 pubmed publisher
    ..DDR1 coordinates the Par3/Par6 cell-polarity complex through its carboxy terminus, binding PDZ domains in Par3 and Par6...
  68. Golińska Zach A, Wiszniewska M, Walusiak Skorupa J. [Guidelines for the preventive health care of hairdressing apprentices]. Med Pr. 2017;68:677-687 pubmed publisher
    ..W niniejszej pracy dokonano tak?e przegl?du pi?miennictwa na podstawie analizy baz danych EBSCO, PubMed, Elsevier i artyku?ów w nich zawartych, powi?zanych tematycznie z tytu?em pracy...
  69. Eichmuller S, Usener D, Dummer R, Stein A, Thiel D, Schadendorf D. Serological detection of cutaneous T-cell lymphoma-associated antigens. Proc Natl Acad Sci U S A. 2001;98:629-34 pubmed
    ..The SCP-1-like gene and cTAGE-1 were shown to be immunogenic and immunologically tumor-specific and may therefore be candidates for immunotherapy targeting CTCL. ..
  70. Tamehiro N, Mujawar Z, Zhou S, Zhuang D, Hornemann T, von Eckardstein A, et al. Cell polarity factor Par3 binds SPTLC1 and modulates monocyte serine palmitoyltransferase activity and chemotaxis. J Biol Chem. 2009;284:24881-90 pubmed publisher
    ..SPTLC1 and -2 subunits, and here we describe a novel protein-protein interaction between SPTLC1 and the PDZ protein Par3 (partitioning defective protein 3)...
  71. Dagher J, Dugay F, Rioux Leclercq N, Verhoest G, Oger E, Bensalah K, et al. Cytoplasmic PAR-3 protein expression is associated with adverse prognostic factors in clear cell renal cell carcinoma and independently impacts survival. Hum Pathol. 2014;45:1639-46 pubmed publisher
    ..We recently demonstrated that the overexpression of PAR-3 protein encoded by the PARD3 gene could be implicated in renal oncogenesis...
  72. Hartleben B, Schweizer H, Lübben P, Bartram M, Möller C, Herr R, et al. Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. J Biol Chem. 2008;283:23033-8 pubmed publisher
    ..We now identify Par3, Par6, and atypical protein kinase C (aPKC) polarity proteins as novel Neph1-Nephrin-associated proteins...
  73. Zhang X, Li W, Liu C, Peng X, Lin J, He S, et al. Alteration of sheep coat color pattern by disruption of ASIP gene via CRISPR Cas9. Sci Rep. 2017;7:8149 pubmed publisher
    ..Further analysis unraveled that modifications happened in one or more than two copies of ASIP gene, and moreover, the additional spontaneous mutations of D9 and/or D5 preceding the ..
  74. Sasamori S, Wiewel A, Thomson V, Kobayashi M, Nakata K, Suzuki H. Potential Causative Mutation for Melanism in Rats Identified in the Agouti Signaling Protein Gene (Asip) of the Rattus rattus Species Complex on Okinawa Island, Japan. Zoolog Sci. 2017;34:513-522 pubmed publisher
    ..in many mammalian species is known to be linked to DNA sequence variation in the agouti signaling protein (Asip) gene, which is a major determinant of eumelanin and pheomelanin pigments in coat color...
  75. Jha H, Sun Z, Upadhyay S, El Naccache D, Singh R, Sahu S, et al. KSHV-Mediated Regulation of Par3 and SNAIL Contributes to B-Cell Proliferation. PLoS Pathog. 2016;12:e1005801 pubmed publisher
    ..b>Par3 (partitioning-defective protein) is a crucial factor in regulating epithelial cell polarity...
  76. Ning Y, Wang X, Guo X, Zhang P, Qu P, Zhang F, et al. Nutrients Other than Selenium Are Important for Promoting Children's Health in Kashin-Beck Disease Areas. Biol Trace Elem Res. 2018;183:233-244 pubmed publisher
    ..0 software. WHO AnthroPlus software was used to analyse the BMI-for-age z-score (BAZ) for estimating the overall nutrition status of children...
  77. Schermer B, Ghenoiu C, Bartram M, Muller R, Kotsis F, Höhne M, et al. The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth. J Cell Biol. 2006;175:547-54 pubmed
    ..Furthermore, pVHL interacts with the Par3-Par6-atypical PKC complex, suggesting a mechanism for linking polarity pathways to microtubule capture and ..
  78. Ebnet K, Aurrand Lions M, Kuhn A, Kiefer F, Butz S, Zander K, et al. The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity. J Cell Sci. 2003;116:3879-91 pubmed
    ..Our findings suggest that JAM-2 affects endothelial cell junctions by its regulated clustering at intercellular contacts, and they support a role for JAM-2, and possibly JAM-3, in tight junction formation of endothelial cells. ..
  79. Argyropoulos G, Stütz A, Ilnytska O, Rice T, Teran Garcia M, Rao D, et al. KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. Physiol Genomics. 2009;36:79-88 pubmed publisher
    ..Furthermore, training-induced changes in submaximal exercise stroke volume may be due to mitochondrial function and variation in KIF5B expression as determined by functional SNPs in its promoter. ..
  80. Namdarian B, Wong E, Galea R, Pedersen J, Chin X, Speirs R, et al. Loss of APKC expression independently predicts tumor recurrence in superficial bladder cancers. Urol Oncol. 2013;31:649-55 pubmed publisher
    ..Our aim was to investigate the role of tight junction proteins, Par3/Par6/atypical protein kinase C (APKC), Discs large (Dlg), and Scribble in human bladder pathogenesis...
  81. Bhatti P, Doody M, Rajaraman P, Alexander B, Yeager M, Hutchinson A, et al. Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. Radiat Res. 2010;173:214-24 pubmed publisher
    ..Even though a complete understanding of the way(s) in which these variants may increase breast cancer risk remains elusive, this approach may yield clues for further investigation. ..
  82. Kong X, Cho M, Anderson W, Coxson H, Muller N, Washko G, et al. Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema. Am J Respir Crit Care Med. 2011;183:43-9 pubmed publisher
    ..Clinical trial registered with www.clinicaltrials.gov (NCT00292552). ..
  83. Zhao J, Gu Y, Fan R, Groome L, Wang Y. Factors derived from preeclamptic placentas perturb polarity protein PARD-3 expression and distribution in endothelial cells. Reprod Sci. 2011;18:164-71 pubmed publisher
    ..The results of PARD-3/VE-cadherin and PARD-3/aPKC? complexes formation in cells treated with placental CM suggest that factors-derived from placenta could interfere both junction protein and polarity protein functions in ECs. ..
  84. Cai Y, Stafford L, Bryan B, Mitchell D, Liu M. G-protein-activated phospholipase C-beta, new partners for cell polarity proteins Par3 and Par6. Oncogene. 2005;24:4293-300 pubmed
    ..we have demonstrated that G-protein-activated phospholipase C-beta (PLC-beta) interacts with cell polarity proteins Par3 and Par6 (Par: partition-defective) to form protein complexes and to mediate downstream signal transduction...
  85. Nishimura T, Kaibuchi K. Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3. Dev Cell. 2007;13:15-28 pubmed
    ..Because Numb interacts with the aPKC binding partner PAR-3, we propose a model in which polarized Numb phosphorylation contributes to cell migration by directing integrin endocytosis to the leading edge. ..
  86. Terawaki S, Kitano K, Mori T, Zhai Y, Higuchi Y, Itoh N, et al. The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module. EMBO J. 2010;29:236-50 pubmed publisher
    ..proteins for binding to PHCCEx domain, Motif-I in CD44 and ephrinB's and the NMDA receptor, and Motif-II in Par3 and JIP2...
  87. Wolters V, Xu W, Zhao X, Walters T, Griffiths A, Silverberg M, et al. Replication of genetic variation in the MYO9B gene in Crohn's disease. Hum Immunol. 2011;72:592-7 pubmed publisher
    Various genes that may influence the intestinal barrier have been identified, including MAGI2, PARD3, and MYO9B. These genes are associated with inflammatory bowel disease (IBD) in several European studies...
  88. Nakajima H, Tanoue T. Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF. J Cell Biol. 2011;195:245-61 pubmed publisher
    ..These findings therefore reveal a novel molecular system regulating the circumferential actomyosin belt in epithelial cells...
  89. Yang Z, Xue B, Umitsu M, Ikura M, Muthuswamy S, Neel B. The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold. Mol Cell. 2012;47:469-83 pubmed publisher
    ..We found that the scaffolding adaptor GAB1 interacts with two polarity proteins, PAR1 and PAR3. GAB1 binds PAR1 and enhances its kinase activity...
  90. Zhang K, Zhao H, Ji Z, Zhang C, Zhou P, Wang L, et al. Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition. Oncogene. 2016;35:1271-82 pubmed publisher
    ..Mechanistically, Shp2 interacts with PAR3 (partitioning-defective 3) via its Src homology-2 domain...
  91. Chen X, An Y, Gao Y, Guo L, Rui L, Xie H, et al. Rare Deleterious PARD3 Variants in the aPKC-Binding Region are Implicated in the Pathogenesis of Human Cranial Neural Tube Defects Via Disrupting Apical Tight Junction Formation. Hum Mutat. 2017;38:378-389 pubmed publisher
    ..In this study, we screened for rare genomic variation of PARD3 in 138 cranial NTD cases and 274 controls...
  92. Zhang Y, Liu J, Peng L, Ren L, Zhang H, Zou L, et al. Comparative transcriptome analysis of molecular mechanism underlying gray-to-red body color formation in red crucian carp (Carassius auratus, red var.). Fish Physiol Biochem. 2017;43:1387-1398 pubmed publisher
    ..involved in the signaling pathway of pigment synthesis, such as the melanogenesis genes (Mitfa, Pax3a, Foxd3, Mc1r, Asip); tyrosine metabolism genes (Tyr, Dct, Tyrp1, Silva, Tat, Hpda); and pteridine metabolism genes (Gch, Xdh, Ptps, Tc)..