parathyroid hormone

Summary

Gene Symbol: parathyroid hormone
Description: parathyroid hormone
Alias: PTH1, parathyroid hormone, parathormone, parathyrin, parathyroid hormone 1, prepro-PTH, preproparathyroid hormone
Species: human
Products:     parathyroid hormone

Top Publications

  1. Arnold A, Horst S, Gardella T, Baba H, Levine M, Kronenberg H. Mutation of the signal peptide-encoding region of the preproparathyroid hormone gene in familial isolated hypoparathyroidism. J Clin Invest. 1990;86:1084-7 pubmed
    b>Preproparathyroid hormone (preproPTH) gene mutation has been proposed as a cause of familial isolated hypoparathyroidism (FIH)...
  2. Hendy G, Bennett H, Gibbs B, Lazure C, Day R, Seidah N. Proparathyroid hormone is preferentially cleaved to parathyroid hormone by the prohormone convertase furin. A mass spectrometric study. J Biol Chem. 1995;270:9517-25 pubmed
    b>Parathyroid hormone (PTH), an 84-amino acid peptide, is the major regulator of blood calcium homeostasis...
  3. Bell O, Gaberman E, Kilav R, Levi R, Cox K, Molkentin J, et al. The protein phosphatase calcineurin determines basal parathyroid hormone gene expression. Mol Endocrinol. 2005;19:516-26 pubmed
    ..Therefore, calcineurin regulates AUF1 posttranslationally in vitro and PTH gene expression in vivo but still allows its physiological regulation by calcium and phosphate. ..
  4. Bellido T, Ali A, Gubrij I, Plotkin L, Fu Q, O Brien C, et al. Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis. Endocrinology. 2005;146:4577-83 pubmed
  5. Reis J, von Muhlen D, Kritz Silverstein D, Wingard D, Barrett Connor E. Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adults. Diabetes Care. 2007;30:1549-55 pubmed
    ..with an increased prevalence of metabolic syndrome; however, previous studies have not accounted for parathyroid hormone (PTH) levels...
  6. Samadfam R, Xia Q, Miao D, Hendy G, Goltzman D. Exogenous PTH and endogenous 1,25-dihydroxyvitamin D are complementary in inducing an anabolic effect on bone. J Bone Miner Res. 2008;23:1257-66 pubmed publisher
    ..An increase in endogenous 1,25(OH)(2)D may therefore facilitate an optimal skeletal anabolic response to PTH and may be relevant to the development of improved therapeutics for enhancing skeletal anabolism. ..
  7. Nechama M, Ben Dov I, Briata P, Gherzi R, Naveh Many T. The mRNA decay promoting factor K-homology splicing regulator protein post-transcriptionally determines parathyroid hormone mRNA levels. FASEB J. 2008;22:3458-68 pubmed publisher
    Serum calcium and phosphate concentrations and experimental chronic kidney failure control parathyroid hormone (PTH) gene expression post-transcriptionally through regulated binding of the trans-acting proteins AUF1 and upstream of N-ras ..
  8. Kestenbaum B, Katz R, de Boer I, Hoofnagle A, Sarnak M, Shlipak M, et al. Vitamin D, parathyroid hormone, and cardiovascular events among older adults. J Am Coll Cardiol. 2011;58:1433-41 pubmed publisher
    The aim of this study was to evaluate associations of 25-hydroxyvitamin D (25-OHD) and parathyroid hormone (PTH) concentrations separately and in combination with incident cardiovascular events and mortality during 14 years of follow-up ..
  9. Deng H, Shen H, Xu F, Deng H, Conway T, Zhang H, et al. Tests of linkage and/or association of genes for vitamin D receptor, osteocalcin, and parathyroid hormone with bone mineral density. J Bone Miner Res. 2002;17:678-86 pubmed
    ..linkage and/or association of the genes for VDR, osteocalcin (also known as bone Gla protein [BGP]), and parathyroid hormone (PTH) with BMD in 630 subjects from 53 human pedigrees...

More Information

Publications124 found, 100 shown here

  1. Katsumata K, Nishizawa K, Unno A, Fujita Y, Tokita A. Association of gene polymorphisms and bone density in Japanese girls. J Bone Miner Metab. 2002;20:164-9 pubmed
    ..We investigated allelic variants of the vitamin D receptor (VDR) gene, the estrogen receptor (ER) gene, the parathyroid hormone (PTH) gene, the Ca-sensing receptor (CaSR) gene, and the beta3-adrenergic receptor (beta3-AR) gene...
  2. Bell O, Silver J, Naveh Many T. Identification and characterization of cis-acting elements in the human and bovine PTH mRNA 3'-untranslated region. J Bone Miner Res. 2005;20:858-66 pubmed
    ..Therefore, different species have alternative cis-acting protein-binding elements that may determine the regulation of PTH mRNA stability in response to changes in serum calcium and phosphate. ..
  3. Tenne M, McGuigan F, Jansson L, Gerdhem P, Obrant K, Luthman H, et al. Genetic variation in the PTH pathway and bone phenotypes in elderly women: evaluation of PTH, PTHLH, PTHR1 and PTHR2 genes. Bone. 2008;42:719-27 pubmed publisher
    b>Parathyroid hormone (PTH) is a key regulator of calcium metabolism. Parathyroid hormone-like hormone (PTHrP) contributes to skeletal development through regulation of chondrocyte proliferation and differentiation during early bone growth...
  4. Chang E, Donkin S, Teegarden D. Parathyroid hormone suppresses insulin signaling in adipocytes. Mol Cell Endocrinol. 2009;307:77-82 pubmed publisher
    Previous reports suggest that parathyroid hormone (PTH) is associated with insulin resistance. This research investigated the effects of PTH on insulin signaling in differentiated 3T3-L1 adipocytes...
  5. Terauchi M, Li J, Bedi B, Baek K, Tawfeek H, Galley S, et al. T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab. 2009;10:229-40 pubmed publisher
    Intermittent administration of parathyroid hormone (iPTH) is used to treat osteoporosis because it improves bone architecture and strength, but the underlying cellular and molecular mechanisms are unclear...
  6. Gardham C, Stevens P, Delaney M, LeRoux M, Coleman A, Lamb E. Variability of parathyroid hormone and other markers of bone mineral metabolism in patients receiving hemodialysis. Clin J Am Soc Nephrol. 2010;5:1261-7 pubmed publisher
    ..of mineral bone disorder in patients with kidney failure is guided by biochemical targets, in particular parathyroid hormone (PTH) concentration...
  7. Røislien J, Van Calster B, Hjelmesæth J. Parathyroid hormone is a plausible mediator for the metabolic syndrome in the morbidly obese: a cross-sectional study. Cardiovasc Diabetol. 2011;10:17 pubmed publisher
    ..Several of the proposed predictors of MS are also possible predictors of parathyroid hormone (PTH)...
  8. Song L. Calcium and Bone Metabolism Indices. Adv Clin Chem. 2017;82:1-46 pubmed publisher
    ..b>Parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D (1,25(OH)2D) control calcium homeostasis, whereas PTH, 1,25(OH)..
  9. Gardella T, Vilardaga J. International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors. Pharmacol Rev. 2015;67:310-37 pubmed publisher
    The type-1 parathyroid hormone receptor (PTHR1) is a family B G protein-coupled receptor (GPCR) that mediates the actions of two polypeptide ligands; parathyroid hormone (PTH), an endocrine hormone that regulates the levels of calcium ..
  10. Andrysiak Mamos E, Zochowska E, Kaźmierczyk Puchalska A, Popow M, Kaczmarska Turek D, Pachucki J, et al. Treatment of severe life threatening hypocalcemia with recombinant human teriparatide in patients with postoperative hypoparathyroidism - a case series. Endokrynol Pol. 2016;67:403-12 pubmed publisher
    ..preparations even with the use of high vitamin D doses, attempts have been made to add recombinant human parathormone (rhPTH) to the treatment schedule...
  11. Jin J, Sun F, Wang G, Yang J, Luo G, Ma H, et al. [The clinical characteristics of 26 cases of hypophosphatemia osteomalacia misdiagnosed as spondyloarthritis]. Zhonghua Nei Ke Za Zhi. 2014;53:847-51 pubmed
    ..Patients with hyperparathyroidism had elevated parathyroid hormone (PTH)...
  12. Coskun Y, Paydas S, Balal M, Soyupak S, Kara E. Bone Disease and Serum Fibroblast Growth Factor-23 Levels in Renal Transplant Recipients. Transplant Proc. 2016;48:2040-5 pubmed publisher
    ..rate (GFR, Modification of Diet in Renal Disease [MDRD] formula), lipid profile, calcium (Ca), phosphorous (P), parathormone (PTH), 25OHD3, serum levels of tacrolimus/cyclosporine, and intact FGF-23 were measured...
  13. Demirkan B. The Roles of Epithelial-to-Mesenchymal Transition (EMT) and Mesenchymal-to-Epithelial Transition (MET) in Breast Cancer Bone Metastasis: Potential Targets for Prevention and Treatment. J Clin Med. 2013;2:264-82 pubmed publisher
    ..insulin-like growth factor I & II (IGF I & II), platelet-derived growth factor (PDGF), parathyroid hormone-related protein (PTH(rP)), vascular endothelial growth factor (VEGF), epithelial growth factors II/I (ErbB/..
  14. Acena A, Pello A, Carda R, Lorenzo O, González Casaús M, Blanco Colio L, et al. Parathormone Levels Are Independently Associated with the Presence of Left Ventricular Hypertrophy in Patients with Coronary Artery Disease. J Nutr Health Aging. 2016;20:659-64 pubmed publisher
    ..Calcidiol (a vitamin D metabolite), parathyroid hormone (PTH), fibroblast growth factor-23, high-sensitivity C-reactive protein, MCP-1 (monocyte chemoattractant ..
  15. Kan S, Zhang W, Mao J, Wang M, Ni L, Zhang M, et al. NF-κB activation contributes to parathyroid cell proliferation in chronic kidney disease. J Nephrol. 2018;31:941-951 pubmed publisher
    ..is characterized by parathyroid gland (PG) hyperplasia, and excessive synthesis and secretion of parathyroid hormone (PTH)...
  16. Fukayama S, Lanske B, Guo J, Kronenberg H, Bringhurst F. Regulation of HSP70 by PTH: a model of gene regulation not mediated by changes in cAMP levels. Am J Physiol. 1996;271:C121-9 pubmed
    b>Parathyroid hormone (PTH) activates both adenylate cyclase and phospholipase C in target cells, and cloned PTH/PTH-related protein (PTHrP) receptor can mediate both responses when expressed in host cells such as LLC-PK1 renal epithelial ..
  17. Portal Núñez S, Ardura J, Lozano D, Martínez de Toda I, de la Fuente M, Herrero Beaumont G, et al. Parathyroid hormone-related protein exhibits antioxidant features in osteoblastic cells through its N-terminal and osteostatin domains. Bone Joint Res. 2018;7:58-68 pubmed publisher
    ..However, classical antioxidants fail to restore osteoblast function. Interestingly, the bone anabolism of parathyroid hormone (PTH) has been shown to be associated with its ability to counteract oxidative stress in osteoblasts...
  18. Di Monaco M, Castiglioni C, Vallero F, Di Monaco R, Tappero R. Parathyroid hormone response to severe vitamin D deficiency is sex associated: an observational study of 571 hip fracture inpatients. J Nutr Health Aging. 2013;17:180-4 pubmed publisher
    To investigate the association between sex and parathyroid hormone response to severe vitamin D deficiency after hip fracture. Cross-sectional study. Rehabilitation hospital in Italy...
  19. Morito N, Yoh K, Usui T, Oishi H, Ojima M, Fujita A, et al. Transcription factor MafB may play an important role in secondary hyperparathyroidism. Kidney Int. 2018;93:54-68 pubmed publisher
    ..Interestingly, secondary hyperparathyroidism, characterized by serum parathyroid hormone elevation and enlargement of parathyroid glands, was suppressed in MafB+/- mice fed the adenine-..
  20. Elseweidy M, Zein N, Aldhamy S, Elsawy M, Saeid S. Policosanol as a new inhibitor candidate for vascular calcification in diabetic hyperlipidemic rats. Exp Biol Med (Maywood). 2016;241:1943-1949 pubmed
    ..GSH), malondialdehyde (MDA)) bone calcification markers (alkaline phosphatase (ALP), Vitamin D, parathyroid hormone (PTH)), lipogram pattern in addition to histochemical demonstration of calcium in the aorta...
  21. Kizilgul M, Ozcelik O, Beysel S, Akinci H, Kan S, Ucan B, et al. Screening for celiac disease in poorly controlled type 2 diabetes mellitus: worth it or not?. BMC Endocr Disord. 2017;17:62 pubmed publisher
    ..05). HDL-cholesterol and parathormone levels were significantly lower in the T2DM group (p < 0.05)...
  22. Ruospo M, Palmer S, Natale P, Craig J, Vecchio M, Elder G, et al. Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD). Cochrane Database Syst Rev. 2018;8:CD006023 pubmed publisher
    ..vascular calcification and bone fracture, and surrogates for such outcomes including serum phosphate, parathyroid hormone (PTH), and FGF23. Two authors independently selected studies for inclusion and extracted study data...
  23. Kalantar Zadeh K, Shah A, Duong U, Hechter R, Dukkipati R, Kovesdy C. Kidney bone disease and mortality in CKD: revisiting the role of vitamin D, calcimimetics, alkaline phosphatase, and minerals. Kidney Int Suppl. 2010;:S10-21 pubmed publisher
    ..active vitamin D) deficiency, 25(OH)-vitamin D deficiency, biochemical hyperparathyroidism, relatively low parathyroid hormone (PTH) level, increased serum alkaline phosphatase (hyperphosphatasemia), elevated fibroblast growth factor (..
  24. Fisher A, Srikusalanukul W, Davis M, Smith P. Cardiovascular diseases in older patients with osteoporotic hip fracture: prevalence, disturbances in mineral and bone metabolism, and bidirectional links. Clin Interv Aging. 2013;8:239-56 pubmed publisher
    ..and CVD in 746 older patients with hip fracture, clinical data were recorded and serum concentrations of parathyroid hormone (PTH), 25-hydroxyvitamin D, calcium, phosphate, magnesium, troponin I, parameters of bone turnover, and ..
  25. Blain H, Jaussent A, Thomas E, Micallef J, Dupuy A, Bernard P, et al. Appendicular skeletal muscle mass is the strongest independent factor associated with femoral neck bone mineral density in adult and older men. Exp Gerontol. 2010;45:679-84 pubmed publisher
    ..grip and knee extension strength, lifetime physical activities, calcium intake, tobacco smoking, and serum parathyroid hormone (PTH), estradiol (E2), free testosterone, dehydroepiandrosterone sulphate (DHEAS), insulin-like growth ..
  26. Salles J. Bone metabolism during pregnancy. Ann Endocrinol (Paris). 2016;77:163-8 pubmed publisher
    ..Mineral regulation is essentially dependent on parathyroid hormone (PTH) and PTH-related protein (PTHrP)...
  27. Karmegam S, Shetty A. Calciphylaxis after parathyroidectomy. Hemodial Int. 2017;21 Suppl 2:S62-S66 pubmed publisher
    ..His parathyroid hormone (PTH) level peaked at 4,191 pg/mL despite being on cinacalcet, sevelamer, and paricalcitol...
  28. Karp H, Kemi V, Lamberg Allardt C, Kärkkäinen M. Mono- and polyphosphates have similar effects on calcium and phosphorus metabolism in healthy young women. Eur J Nutr. 2013;52:991-6 pubmed publisher
    ..The aim of this study was to determine whether the effects of MP and PP salts differ on markers of Ca and P metabolism in young women...
  29. Sayıklı ÅžimÅŸek Ã, Nur Sonuç KaraboÄŸa M, Sezgintürk M. A new immobilization procedure for development of an electrochemical immunosensor for parathyroid hormone detection based on gold electrodes modified with 6-mercaptohexanol and silane. Talanta. 2015;144:210-8 pubmed publisher
    Fabrication of a new electrochemical impedance-based biosensor for the analysis of parathyroid hormone (PTH), using self-assembled monolayers (SAMs) of mercaptohexanol and (3-Aminopropyl) triethoxysilane on gold electrodes, was ..
  30. Dowa Y, Kawai M, Kanazawa H, Iwanaga K, Matsukura T, Heike T. Screening for secondary hyperparathyroidism in preterm infants. Pediatr Int. 2016;58:988-992 pubmed publisher
    ..Because parathyroid hormone (PTH) mobilizes calcium and phosphate from the bone, hyperparathyroidism worsens osteopathy of prematurity...
  31. Meireles M, Kamimura M, Dalboni M, Giffoni de Carvalho J, Aoike D, Cuppari L. Effect of cholecalciferol on vitamin D-regulatory proteins in monocytes and on inflammatory markers in dialysis patients: A randomized controlled trial. Clin Nutr. 2016;35:1251-1258 pubmed publisher
    ..Restoration of vitamin D status of patients undergoing dialysis promoted upregulation of CYP27B1 and VDR expression in monocytes and a decrease in circulating inflammatory markers. ..
  32. Sneddon W, Ruiz G, Gallo L, Xiao K, Zhang Q, Rbaibi Y, et al. Convergent Signaling Pathways Regulate Parathyroid Hormone and Fibroblast Growth Factor-23 Action on NPT2A-mediated Phosphate Transport. J Biol Chem. 2016;291:18632-42 pubmed publisher
    b>Parathyroid hormone (PTH) and FGF23 are the primary hormones regulating acute phosphate homeostasis...
  33. Reddy A, Chand G, Sabaretnam M, Mishra A, Agarwal G, Agarwal A, et al. Prospective evaluation of intra-operative quick parathyroid hormone assay as an early predictor of post thyroidectomy hypocalcaemia. Int J Surg. 2016;34:103-108 pubmed publisher
    ..We prospectively evaluated the utility of Intra-operative serum quick parathyroid hormone level measurement twenty minutes after total thyroidectomy in predicting post-operative hypocalcemia...
  34. Lavryk O, Siperstein A. Use of Calcium and Parathyroid Hormone Nomogram to Distinguish Between Atypical Primary Hyperparathyroidism and Normal Patients. World J Surg. 2017;41:122-128 pubmed publisher
    ..more complex, as fewer patients present with classic phenotype of concomitant elevation of calcium and parathyroid hormone (PTH)...
  35. Yao P, Sun L, Lu L, Ding H, Chen X, Tang L, et al. Effects of Genetic and Nongenetic Factors on Total and Bioavailable 25(OH)D Responses to Vitamin D Supplementation. J Clin Endocrinol Metab. 2017;102:100-110 pubmed publisher
    ..Serum 25(OH)D, vitamin D-binding protein (VDBP), parathyroid hormone (PTH) and calcium were measured, and 25(OH)DBio was calculated based on VDBP levels...
  36. Aniteli T, de Siqueira F, dos Reis L, Dominguez W, de Oliveira E, Castelucci P, et al. Effect of variations in dietary Pi intake on intestinal Pi transporters (NaPi-IIb, PiT-1, and PiT-2) and phosphate-regulating factors (PTH, FGF-23, and MEPE). Pflugers Arch. 2018;470:623-632 pubmed publisher
    ..Serum phosphate, fractional excretion of phosphate, intact serum fibroblast growth factor 23 (FGF-23), and parathyroid hormone (PTH) were significantly higher and ionized calcium was significantly lower in the Nx/HPi group ..
  37. Perin J, Prokopowicz G, Furtado M, Papas K, Steele K. A Randomized Trial of a Novel Chewable Multivitamin and Mineral Supplement Following Roux-en-Y Gastric Bypass. Obes Surg. 2018;28:2406-2420 pubmed publisher
    ..A, B-12, D, E-?, E-?/?, thiamine, folate, iron, iron-binding capacity, iron saturation, prealbumin, and parathyroid hormone (PTH) were measured at 3 and 6 months postoperatively...
  38. Keutmann H, Niall H, O Riordan J, Potts J. A reinvestigation of the amino-terminal sequence of human parathyroid hormone. Biochemistry. 1975;14:1842-7 pubmed
    The sequence of the amino-terminal portion of human parathyroid hormone, particularly the identity of residues 22, 28, and 30 (the subject of discrepancies in recent published reports), has been reexamined by two basic methods of ..
  39. Nemeth E, Goodman W. Calcimimetic and Calcilytic Drugs: Feats, Flops, and Futures. Calcif Tissue Int. 2016;98:341-58 pubmed publisher
    ..agonists (type I) or positive allosteric modulators (type II); calcimimetics inhibit the secretion of parathyroid hormone (PTH)...
  40. Kimura S, Saito M, Kida Y, Seki A, Isaka Y, Marumo K. Effects of raloxifene and alendronate on non-enzymatic collagen cross-links and bone strength in ovariectomized rabbits in sequential treatments after daily human parathyroid hormone (1-34) administration. Osteoporos Int. 2017;28:1109-1119 pubmed publisher
    This study investigated the effects of raloxifene and alendronate to follow parathyroid hormone (PTH) on bone collagen and biomechanical properties in ovariectomized rabbits...
  41. Noltes M, Coester A, van der Horst Schrivers A, Dorgelo B, Jansen L, Noordzij W, et al. Localization of parathyroid adenomas using 11C-methionine pet after prior inconclusive imaging. Langenbecks Arch Surg. 2017;402:1109-1117 pubmed publisher
    ..A preoperatively correct localized adenoma leads to a more focused surgical approach (MIP) potentially reducing duration of surgery and potentially healthcare costs. ..
  42. Jean G, Souberbielle J, Chazot C. Vitamin D in Chronic Kidney Disease and Dialysis Patients. Nutrients. 2017;9: pubmed publisher
    ..activator (VDRA) use is associated with better outcomes and it is more efficient for decreasing the serum parathormone (PTH) levels...
  43. Reyes M, Karaca A, Bastepe M, Gulcelik N, Juppner H. A novel deletion involving GNAS exon 1 causes PHP1A and further refines the region required for normal methylation at exon A/B. Bone. 2017;103:281-286 pubmed publisher
    ..This novel deletion therefore refines further the region between exon A/B and exon 1 that is critical for establishing or maintaining normal methylation at GNAS exon A/B. ..
  44. Diepenhorst N, Rueda P, Cook A, Pastoureau P, Sabatini M, Langmead C. G protein-coupled receptors as anabolic drug targets in osteoporosis. Pharmacol Ther. 2018;184:1-12 pubmed publisher
    ..strontium ranelate and teriparatide, mediate their actions via the G protein-coupled calcium-sensing and parathyroid hormone-1 receptors, respectively...
  45. Iguchi A, Yamamoto S, Yamazaki M, Tasaki K, Suzuki Y, Kazama J, et al. Effect of ferric citrate hydrate on FGF23 and PTH levels in patients with non-dialysis-dependent chronic kidney disease with normophosphatemia and iron deficiency. Clin Exp Nephrol. 2018;22:789-796 pubmed publisher
    ..In patients with normophosphatemia with chronic kidney disease (CKD), fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH) increase urinary phosphate excretion while maintaining serum phosphate within the normal range...
  46. Tajima T, Menuki K, Okuma K, Tsukamoto M, Fukuda H, Okada Y, et al. Cortical bone loss due to skeletal unloading in aldehyde dehydrogenase 2 gene knockout mice is associated with decreased PTH receptor expression in osteocytes. Bone. 2018;110:254-266 pubmed publisher
    ..Bone formation signals such as parathyroid hormone receptor (PTHR) were significantly decreased in KOTS compared with the levels in KOGC...
  47. Mahmoudi T, Karimi K, Arkani M, Farahani H, Nobakht H, Dabiri R, et al. Parathyroid hormone gene rs6256 and calcium sensing receptor gene rs1801725 variants are not associated with susceptibility to colorectal cancer in Iran. Asian Pac J Cancer Prev. 2014;15:6035-9 pubmed
    ..Given the vital role of calcium sensing receptor (CaSR) and parathyroid hormone (PTH) in the maintenance of calcium homeostasis, we explored whether the rs1801725 (A986S) variant located ..
  48. Balsa J, Lafuente C, Gómez Martín J, Galindo J, Peromingo R, García Moreno F, et al. The role of serum osteoprotegerin and receptor-activator of nuclear factor-κB ligand in metabolic bone disease of women after obesity surgery. J Bone Miner Metab. 2016;34:655-661 pubmed
    ..and receptor-activator of nuclear factor-κB ligand ratio also correlated inversely with serum parathormone and osteocalcin. Bone mineral density at the lumbar spine was associated with age (β = -0...
  49. Lv F, Xu X, Wang J, Liu Y, Jiang Y, Wang O, et al. A novel mutation in CLDN16 results in rare familial hypomagnesaemia with hypercalciuria and nephrocalcinosis in a Chinese family. Clin Chim Acta. 2016;457:69-74 pubmed publisher
    ..We detected a novel mutation in CLDN16 for the first time. The clinical and genetic findings from this study will help to expand the understanding of this rare disease, FHHNC. ..
  50. Shamsayei M, Yamini Y, Asiabi H. Polythiophene/graphene oxide nanostructured electrodeposited coating for on-line electrochemically controlled in-tube solid-phase microextraction. J Chromatogr A. 2016;1475:8-17 pubmed publisher
    ..Finally, under the optimal conditions, the method was applied for the analysis of the drugs in human urine and plasma pretreated samples and good results were obtained. ..
  51. Törmänen S, Porsti I, Lakkisto P, Tikkanen I, Niemela O, Paavonen T, et al. Endothelin A receptor blocker and calcimimetic in the adenine rat model of chronic renal insufficiency. BMC Nephrol. 2017;18:323 pubmed publisher
    ..Sitaxentan and cinacalcet reduced kidney renin mRNA by 40%, while their combination alleviated tubulointerstitial damage and urinary calcium loss, and increased kidney tissue ACE2 mRNA. ..
  52. Marcucci G, Cianferotti L, Parri S, Altieri P, Arvat E, Benvenga S, et al. HypoparaNet: A Database of Chronic Hypoparathyroidism Based on Expert Medical-Surgical Centers in Italy. Calcif Tissue Int. 2018;103:151-163 pubmed publisher
    Hypoparathyroidism is a rare disease characterized by low serum calcium levels and absent or deficient parathyroid hormone level. Regarding the epidemiology of chronic hypoparathyroidism, there are limited data in Italy and worldwide...
  53. Meola A, Vignali E, Matrone A, Cetani F, Marcocci C. Efficacy and safety of long-term management of patients with chronic post-surgical hypoparathyroidism. J Endocrinol Invest. 2018;41:1221-1226 pubmed publisher
    ..Two patients never had values in the target range. Treatment of chronic PO-HypoPT with calcium and activated vitamin D metabolites is suboptimal and associated with an increased risk of renal complications. ..
  54. Calvo N, Gentili C, de Boland A. The early phase of programmed cell death in Caco-2 intestinal cells exposed to PTH. J Cell Biochem. 2008;105:989-97 pubmed publisher
    ..b>Parathyroid hormone (PTH) function as a major mediator of bone remodeling and as an essential regulator of calcium homeostasis...
  55. Hagström E, Michaelsson K, Melhus H, Hansen T, Ahlstrom H, Johansson L, et al. Plasma-parathyroid hormone is associated with subclinical and clinical atherosclerotic disease in 2 community-based cohorts. Arterioscler Thromb Vasc Biol. 2014;34:1567-73 pubmed publisher
    ..Diseases with elevated circulating parathyroid hormone (PTH) such as primary hyperparathyroidism and chronic renal failure have been shown to be associated with ..
  56. Arkader A, Woon R, Gilsanz V. Can Subclinical Rickets Cause SCFE? A Prospective, Pilot Study. J Pediatr Orthop. 2015;35:e72-5 pubmed publisher
    ..Although obese children are known to have lower levels of vitamin D and a higher prevalence of SCFE, we found no correlation between low vitamin D and the development of SCFE in this subset of patients. ..
  57. Tsentidis C, Gourgiotis D, Kossiva L, Marmarinos A, Doulgeraki A, Karavanaki K. Sclerostin distribution in children and adolescents with type 1 diabetes mellitus and correlation with bone metabolism and bone mineral density. Pediatr Diabetes. 2016;17:289-99 pubmed publisher
    ..factor-kappaB ligand (s-RANKL), osteoprotegerin, osteocalcin, C-telopeptide crosslinks, electrolytes, parathyroid hormone (PTH), and total 25(OH)D were measured...
  58. Schlottmann F, Arbulú A, Sadava E, Mendez P, Pereyra L, Fernández Vila J, et al. Algorithm for early discharge after total thyroidectomy using PTH to predict hypocalcemia: prospective study. Langenbecks Arch Surg. 2015;400:831-6 pubmed publisher
    ..The aim of this study was to determine whether postoperative parathyroid hormone (PTH) levels predict hypocalcemia in order to design an algorithm for early discharge...
  59. Ticinesi A, Nouvenne A, Ferraro P, Folesani G, Lauretani F, Allegri F, et al. Idiopathic Calcium Nephrolithiasis and Hypovitaminosis D: A Case-control Study. Urology. 2016;87:40-5 pubmed publisher
    ..Serum parathormone, calcium, phosphorus, and urinary factors of lithogenic risk were available in stone formers (SF)...
  60. Donderski R, Strózecki P, Sulikowska B, Grajewska M, Miśkowiec I, Stefanska A, et al. Aldosterone antagonist therapy and its relationship with inflammation, fibrosis, thrombosis, mineral-bone disorder and cardiovascular complications in peritoneal dialysis (PD) patients. Int Urol Nephrol. 2017;49:1867-1873 pubmed publisher
    ..Further studies are required to determine relationship between mineralocorticoid receptor blockade and mineral-bone disturbances in PD patients. ..
  61. Fernández Galán E, Bedini J, Filella X. Analytical verification and method comparison of the ADVIA Centaur® Intact Parathyroid Hormone assay. Clin Biochem. 2017;50:1222-1227 pubmed publisher
    This study is the first verification of the novel iPTH Siemens ADVIA Centaur® Intact Parathyroid Hormone (iPTHm) chemiluminescence immunoassay based on monoclonal antibodies...
  62. Sulimani R, Mohammed A, Alshehri S, Alfadda A, Al Othman A, Khan A. A weekly 35,000 IU vitamin D supplementation improves bone turnover markers in vitamin D deficient Saudi adolescent females. Arch Osteoporos. 2017;12:85 pubmed publisher
    ..There was improvement in the levels of parathyroid hormone (PTH), osteocalcin, and carboxy-terminal telopeptides of crosslinks of type 1 collagen (βCTX) which ..
  63. El Husseini A, Wang K, Edon A, Saxon D, Lima F, Sloan D, et al. Value of Intraoperative Parathyroid Hormone Assay during Parathyroidectomy in Dialysis and Renal Transplant Patients with Secondary and Tertiary Hyperparathyroidism. Nephron. 2017;: pubmed publisher
    ..transplant patients with secondary and tertiary hyperparathyroidism (HPT), the value of intraoperative parathyroid hormone (ioPTH) during parathyroidectomy (PTX) and its association with long-term PTH levels are unknown...
  64. Alonso V, Ardura J, Wang B, Sneddon W, Friedman P. A naturally occurring isoform inhibits parathyroid hormone receptor trafficking and signaling. J Bone Miner Res. 2011;26:143-55 pubmed publisher
    b>Parathyroid hormone (PTH) regulates calcium homeostasis and bone remodeling through its cognitive receptor (PTHR)...
  65. Hirai T, Kobayashi T, Nishimori S, Karaplis A, Goltzman D, Kronenberg H. Bone Is a Major Target of PTH/PTHrP Receptor Signaling in Regulation of Fetal Blood Calcium Homeostasis. Endocrinology. 2015;156:2774-80 pubmed publisher
    ..They also show that PTH-independent deposition of calcium in bone is the major controller of fetal blood calcium level. ..
  66. Abd Alamir M, Radulescu V, Goyfman M, Mohler E, Gao Y, Budoff M. Prevalence and correlates of mitral annular calcification in adults with chronic kidney disease: Results from CRIC study. Atherosclerosis. 2015;242:117-22 pubmed publisher
    ..These results are suggested by mechanisms of dysregulation of inflammation, hormones, and electrolytes in subjects with renal disease. ..
  67. Hacıhamdioğlu D, Düzova A, Alehan D, Oğuz B, Beşbaş N. Circulating fibroblast growth factor 23 in children on peritoneal dialysis is associated with effective dialysis. Turk J Pediatr. 2015;57:9-16 pubmed
    ..66-17.75) undergoing PD for 22 months (range 2-98). Serum FGF23, serum phosphorus, calcium, intact parathyroid hormone (iPTH), 25(OH) vitamin D, 1,25(OH)2 vitamin D and Kt/V urea, left ventricular mass (LVM) and LVM index (..
  68. Kitada M, Yasuda S, Nana T, Ishibashi K, Hayashi S, Okazaki S. Surgical treatment for mediastinal parathyroid adenoma causing primary hyperparathyroidism. J Cardiothorac Surg. 2016;11:44 pubmed publisher
    Primary hyperparathyroidism is a rare disease characterized by excessive secretion of parathyroid hormone from parathyroid adenoma, hyperplasia, or malignancy. The clinical symptoms of the condition are those of hypercalcemia...
  69. Strain G, Torghabeh M, Gagner M, Ebel F, Dakin G, Connolly D, et al. Nutrient Status 9 Years After Biliopancreatic Diversion with Duodenal Switch (BPD/DS): an Observational Study. Obes Surg. 2017;27:1709-1718 pubmed publisher
    ..Magnesium fluctuated during observation. Major deficits in nutrient status occurred and persisted after surgery although supplementation was prescribed. Interventions are mandated to avoid nutrient deficiency. ..
  70. van der Plas W, Noltes M, Schaeffers A, Brouwers A, van der Horst Schrivers A, Kruijff S. [Diagnostic approach and treatment of primary hyperparathyroidism]. Ned Tijdschr Geneeskd. 2017;161:D1870 pubmed
    ..is characterised by elevated serum calcium levels due to elevated levels, or insufficient suppression, of parathyroid hormone (PTH).- The incidence of PHPT has increased in recent years...
  71. Spasovski G. Bone biopsy as a diagnostic tool in the assessment of renal osteodystrophy. Int J Artif Organs. 2004;27:918-23 pubmed
    ..Hence, transiliac bone biopsy remains the gold standard for the diagnosis of renal osteodystrophy...
  72. Rashtchizadeh N, Ghorbanihaghjo A, Argani H, Mahmoudi Meimand S, Safa J, Vatankhahan H, et al. Serum receptor activator of nuclear factor-? B ligand, osteoprotegrin, and intact parathyroid hormone in hemodialysis and renal transplant patients. Ther Apher Dial. 2012;16:600-4 pubmed publisher
    ..Receptor activator of nuclear factor-? B ligand, osteoprotegrin, intact parathyroid hormone, calcium, and phosphorus were measured in blood samples of 45 hemodialysis and 45 age-matched renal ..
  73. Throckmorton D, Kurscheid Reich D, Rosales O, Rodriguez Commes J, Lopez R, Sumpio B, et al. Parathyroid hormone effects on signaling pathways in endothelial cells vary with peptide concentration. Peptides. 2002;23:79-85 pubmed
    We have previously reported that parathyroid hormone (PTH) has specific effects on a human umbilical vein endothelial cell line. Further studies were performed to characterize the signaling cascades initiated by PTH...
  74. Giroux S, Elfassihi L, Clément V, Bussières J, Bureau A, Cole D, et al. High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density. Bone. 2010;47:975-81 pubmed publisher
    ..The results reported in this study suggest a role for CSF3R in the determination of bone density in women. ..
  75. Ulu S, Ulaşli A, Yaman F, Yaman G, Ozkececi G, Yuksel S. The relationship between vitamin D and PTH levels and cardiovascular risk in the elderly hypertensives. Clin Exp Hypertens. 2014;36:52-7 pubmed publisher
    In this study, we aimed to investigate the relationship between vitamin D, parathyroid hormone (PTH) and cardiovascular risk (CVR) in hypertensive patients aged 65 years and over...
  76. Pacifici R. T cells, osteoblasts, and osteocytes: interacting lineages key for the bone anabolic and catabolic activities of parathyroid hormone. Ann N Y Acad Sci. 2016;1364:11-24 pubmed publisher
    ..T cells regulate the differentiation and life span of stromal cells (SCs) and their responsiveness to parathyroid hormone (PTH) via costimulatory molecules expressed on their surface...
  77. Andrukhova O, Streicher C, Zeitz U, Erben R. Fgf23 and parathyroid hormone signaling interact in kidney and bone. Mol Cell Endocrinol. 2016;436:224-39 pubmed publisher
    ..and Klotho/VDR compound mutants were characterized by hypocalcemia, hyperphosphatemia, and very high serum parathyroid hormone (PTH)...
  78. Kasperk C. [Hypercalcemic crisis and hypocalcemic tetany]. Internist (Berl). 2017;58:1029-1036 pubmed publisher
    ..c. parathyroid hormone 1-84 should be considered to stabilize calcium levels and to lower the dosage of calcium and vitamin D ..
  79. Bahler S, Muller W, Linder T, Frotzler A, Fischli S, Aqtashi B, et al. [Intraoperative parathyroid hormone measurement is the best predictor of postoperative symptomatic hypocalcemia]. HNO. 2017;: pubmed publisher
    ..risk factors for transient postoperative hypocalcemia (HC) and to define cutoff values for perioperative parathyroid hormone (PTH) and calcium parameters (Ca) to reduce the morbidity of symptomatic HC...
  80. Namdaroğlu S, Korkmaz S, Altuntas F. Management of mobilization failure in 2017. Transfus Apher Sci. 2017;56:836-844 pubmed publisher
    ..Different CXCR4 inhibitors, growth hormone, VLA4 inhibitors, and parathormone, have been cited as new agents for mobilization failure in recent years...
  81. Shimizu M, Shimizu N, Tsang J, Petroni B, Khatri A, Potts J, et al. Residue 19 of the parathyroid hormone (PTH) modulates ligand interaction with the juxtamembrane region of the PTH-1 receptor. Biochemistry. 2002;41:13224-33 pubmed
    Recent data suggest that the binding of parathyroid hormone (PTH)-(1-34) to the PTH-1 receptor (P1R) involves a high-affinity interaction between the C-terminal (15-34) domain of the ligand and the amino-terminal extracellular (N) domain ..
  82. Gensure R, Shimizu N, Tsang J, Gardella T. Identification of a contact site for residue 19 of parathyroid hormone (PTH) and PTH-related protein analogs in transmembrane domain two of the type 1 PTH receptor. Mol Endocrinol. 2003;17:2647-58 pubmed
    ..The findings also support a molecular model in which the 1-21 region of PTH binds to the extracellular face of the P1R J domain as an alpha-helix. ..
  83. Galitzer H, Lavi Moshayoff V, Nechama M, Meir T, Silver J, Naveh Many T. The calcium-sensing receptor regulates parathyroid hormone gene expression in transfected HEK293 cells. BMC Biol. 2009;7:17 pubmed publisher
    The parathyroid calcium receptor determines parathyroid hormone secretion and the response of parathyroid hormone gene expression to serum Ca2+ in the parathyroid gland...
  84. Hoi W, Leow M, Sule A, Lee H, Mmed T, Tay J. Hyperparathyroidism due to eutopic PTH secretion from an ectopic intrathymic parathyroid cyst. Ann Thorac Cardiovasc Surg. 2011;17:511-3 pubmed
    ..1 mg/dL. Normocalcemia was finally achieved following surgical extirpation of the mass. Histology confirmed an intrathymic parathyroid cyst. Definitive treatment by resection of the mass is potentially curative. ..
  85. Hagström E, Kilander L, Nylander R, Larsson E, Michaelsson K, Melhus H, et al. Plasma parathyroid hormone is associated with vascular dementia and cerebral hyperintensities in two community-based cohorts. J Clin Endocrinol Metab. 2014;99:4181-9 pubmed publisher
    ..In two community-based samples, PTH predicted clinically diagnosed vascular dementia as well as neuroimaging indices of cerebral small vessel disease. Our data suggest a role for PTH in the development of vascular dementia. ..
  86. Huang T, Huang K, Lin S, Chuang P, Shih H, Lee M, et al. Effects of teriparatide on cementless bipolar hemiarthroplasty in patients with osteoporotic femoral neck fractures. BMC Musculoskelet Disord. 2016;17:300 pubmed publisher
    ..Teriparatide (parathyroid hormone [PTH1-34]) can improve bone-implant stability in some basic studies...
  87. Verdelli C, Avagliano L, Guarnieri V, Cetani F, Ferrero S, Vicentini L, et al. Expression, function, and regulation of the embryonic transcription factor TBX1 in parathyroid tumors. Lab Invest. 2017;97:1488-1499 pubmed publisher
    ..In conclusion, TBX1 is expressed in adult parathyroid cells and deregulated in parathyroid tumors, where TBX1 deficiency may potentially contribute to the low proliferative nature of parathyroid tumors. ..
  88. Jenabi A, Jabbari M, Ziaie H. Comparing the values of intact parathormone and 1- 84 PTH to predict hyperparathyroidism in hemodialysis patients. J Nephropathol. 2017;6:248-253 pubmed publisher
    ..SHPT is manifested by elevation of parathyroid hormone (PTH) and accurate determining the level of serum PTH is very essential for early diagnosis of SHPT ..
  89. Coen G, Mantella D, Sardella D, Beraldi M, Ferrari I, Pierantozzi A, et al. Asymmetric dimethylarginine, vascular calcifications and parathyroid hormone serum levels in hemodialysis patients. J Nephrol. 2009;22:616-22 pubmed
    ..This study explores also a possible relation between ADMA and parathyroid hormone (PTH) serum levels, which are known to be linked to increased rates of cardiovascular death...
  90. Laohapitakworn S, Thongbunchoo J, Nakkrasae L, Krishnamra N, Charoenphandhu N. Parathyroid hormone (PTH) rapidly enhances CFTR-mediated HCO?? secretion in intestinal epithelium-like Caco-2 monolayer: a novel ion regulatory action of PTH. Am J Physiol Cell Physiol. 2011;301:C137-49 pubmed publisher
    Besides being a Ca²-regulating hormone, parathyroid hormone (PTH) has also been shown to regulate epithelial transport of certain ions, such as Cl, HCO?, and Na, particularly in the kidney...
  91. Tajar A, Lee D, Pye S, O Connell M, Ravindrarajah R, Gielen E, et al. The association of frailty with serum 25-hydroxyvitamin D and parathyroid hormone levels in older European men. Age Ageing. 2013;42:352-9 pubmed publisher
    ..endocrine axis and frailty remains undefined, with few studies examining the joint effect of vitamin D and parathyroid hormone (PTH) levels...
  92. Liu X, Zou C, Yu C, Xie R, Sui M, Mu S, et al. Original Research: Atorvastatin prevents rat cardiomyocyte hypertrophy induced by parathyroid hormone 1-34 associated with the Ras-ERK signaling. Exp Biol Med (Maywood). 2016;241:1745-50 pubmed publisher
    We investigated the effects of atorvastatin (Ator) on cardiomyocyte hypertrophy (CMH) induced by rat parathyroid hormone 1-34 (PTH1-34) and Ras-extracellular signal regulated protein kinases 1/2 (ERK1/2) signaling...