Gene Symbol: PAM16
Description: presequence translocase associated motor 16
Alias: CGI-136, MAGMAS, SMDMDM, TIM16, TIMM16, mitochondrial import inner membrane translocase subunit TIM16, magmas-like protein, mitochondria associated protein involved in granulocyte macrophage colony stimulating factor signal transduction, mitochondria-associated granulocyte macrophage CSF-signaling molecule, presequence translocase associated motor 16 homolog
Species: human
Products:     PAM16

Top Publications

  1. Jubinsky P, Short M, Mutema G, Morris R, Ciraolo G, Li M. Magmas expression in neoplastic human prostate. J Mol Histol. 2005;36:69-75 pubmed
    b>Magmas, is a 13-kDa mitochondrial protein which is ubiquitously expressed in eukaryotic cells...
  2. Elsner S, Simian D, Iosefson O, Marom M, Azem A. The mitochondrial protein translocation motor: structural conservation between the human and yeast Tim14/Pam18-Tim16/Pam16 co-chaperones. Int J Mol Sci. 2009;10:2041-53 pubmed publisher
    ..Of particular interest for us is the human Tim14/Pam18-Tim16/Pam16 complex...
  3. Jubinsky P, Messer A, Bender J, Morris R, Ciraolo G, Witte D, et al. Identification and characterization of Magmas, a novel mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction. Exp Hematol. 2001;29:1392-402 pubmed
    ..A gene, named Magmas (mitochondria-associated granulocyte macrophage CSF signaling molecule), was shown to be rapidly induced when ..
  4. Sinha D, Joshi N, Chittoor B, Samji P, D Silva P. Role of Magmas in protein transport and human mitochondria biogenesis. Hum Mol Genet. 2010;19:1248-62 pubmed publisher
    b>Magmas, a conserved mammalian protein essential for eukaryotic development, is overexpressed in prostate carcinomas and cells exposed to granulocyte-macrophage colony-stimulating factor (GM-CSF)...
  5. Garg D, Papale P, Colucci S, Longo A. Long-lived compositional heterogeneities in magma chambers, and implications for volcanic hazard. Sci Rep. 2019;9:3321 pubmed publisher
    b>Magmas discharged during individual volcanic eruptions commonly display compositional variations interpreted as new arrivals at shallow depth of more primitive, hotter, volatile-rich magma batches mixing with resident, colder, partially ..
  6. Araya N, Nakamura M, Yasuda A, Okumura S, Sato T, Iguchi M, et al. Shallow magma pre-charge during repeated Plinian eruptions at Sakurajima volcano. Sci Rep. 2019;9:1979 pubmed publisher
    ..We propose that the magmas were fed from a thick conduit pre-charged from deeper reservoirs...
  7. Barth A, Edmonds M, Woods A. Valve-like dynamics of gas flow through a packed crystal mush and cyclic strombolian explosions. Sci Rep. 2019;9:821 pubmed publisher
    Strombolian volcanic explosions are commonly attributed to the rise and burst of conduit-filling gas slugs. The magmas associated with strombolian activity, however, are typically not only volatile-rich but also highly crystalline, with ..
  8. Tang M, Lee C, Chen K, Erdman M, Costin G, Jiang H. Nb/Ta systematics in arc magma differentiation and the role of arclogites in continent formation. Nat Commun. 2019;10:235 pubmed publisher
    ..Exactly how felsic crust forms when basaltic magmas are the dominant products of melting the mantles of rocky planets is unclear...
  9. Reekie C, Jenner F, Smythe D, Hauri E, Bullock E, Williams H. Sulfide resorption during crustal ascent and degassing of oceanic plateau basalts. Nat Commun. 2019;10:82 pubmed publisher
    Mantle plume-related magmas typically have higher chalcophile and siderophile element (CSE) contents than mid-ocean ridge basalts (MORB). These differences are often attributed to sulfide-under-saturation of plume-related melts...

More Information


  1. Geyer A, Álvarez Valero A, Gisbert G, Aulinas M, Hernández Barreña D, Lobo A, et al. Deciphering the evolution of Deception Island's magmatic system. Sci Rep. 2019;9:373 pubmed publisher
    ..the existence of a complex plumbing system composed of several shallow magma chambers (≤10 km depth) fed by magmas raised directly from the mantle, or from a magma accumulation zone located at the crust-mantle boundary (15-20 ..
  2. Day J, Tait K, Udry A, Moynier F, Liu Y, Neal C. Martian magmatism from plume metasomatized mantle. Nat Commun. 2018;9:4799 pubmed publisher
    ..Generation of martian magmas can be explained by temporally distinct melting episodes within and below dynamically supported and variably ..
  3. Di K, Lomeli N, Bota D, Das B. Magmas inhibition as a potential treatment strategy in malignant glioma. J Neurooncol. 2019;141:267-276 pubmed publisher
    ..colony-stimulating factor signal transduction) is a nuclear gene that encodes the mitochondrial import inner membrane translocase subunit Tim16. Magmas is highly conserved, ubiquitously expressed in mammalian cells, and is ..
  4. Jackson M, Blundy J, Sparks R. Chemical differentiation, cold storage and remobilization of magma in the Earth's crust. Nature. 2018;564:405-409 pubmed publisher
    ..Reactive melt flow in mush reservoirs produces the low-crystallinity, chemically differentiated (silicic) magmas that ascend to form shallower intrusions or erupt to the surface11-13...
  5. Rielli A, Tomkins A, Nebel O, Brugger J, Etschmann B, Paterson D. Garnet peridotites reveal spatial and temporal changes in the oxidation potential of subduction. Sci Rep. 2018;8:16411 pubmed publisher
    ..Consequently, early magmas derived from partial melting of metasomatised mantle may have had suitable fO2 to generate porphyry Cu-..
  6. Ovalle J, La Cruz N, Reich M, Barra F, Simon A, Konecke B, et al. Formation of massive iron deposits linked to explosive volcanic eruptions. Sci Rep. 2018;8:14855 pubmed publisher
    The genetic link between magmas and ore deposit formation is well documented by studies of fossil hydrothermal systems associated with magmatic intrusions at depth...
  7. Fiedrich A, Martin L, Storck J, Ulmer P, Heinrich C, Bachmann O. The influence of water in silicate melt on aluminium excess in plagioclase as a potential hygrometer. Sci Rep. 2018;8:12421 pubmed publisher
    Measuring water contents of magmas is fundamental to resolving a number of geological questions, such as the mechanisms of silicic magma evolution, the triggering of volcanic eruptions, and the formation of porphyry copper deposits...
  8. Benard A, Klimm K, Woodland A, Arculus R, Wilke M, Botcharnikov R, et al. Oxidising agents in sub-arc mantle melts link slab devolatilisation and arc magmas. Nat Commun. 2018;9:3500 pubmed publisher
    Subduction zone magmas are more oxidised on eruption than those at mid-ocean ridges...
  9. Gordeychik B, Churikova T, Kronz A, Sundermeyer C, Simakin A, Wörner G. Growth of, and diffusion in, olivine in ultra-fast ascending basalt magmas from Shiveluch volcano. Sci Rep. 2018;8:11775 pubmed publisher
    ..At the same time, Ca, and to an even greater extent Cr, Al, and P have oscillatory growth patterns in the crystals overgrowth. Our data show that magma ascent can be extremely short during maar/tuff ring eruption. ..
  10. Codillo E, Le Roux V, Marschall H. Arc-like magmas generated by mélange-peridotite interaction in the mantle wedge. Nat Commun. 2018;9:2864 pubmed publisher ascend as diapirs from the slab-top and transfer their compositional signatures to the source region of arc magmas. However, the compositions of melts that result from the interaction of mélanges with a peridotite wedge remain ..
  11. Cassidy M, Manga M, Cashman K, Bachmann O. Controls on explosive-effusive volcanic eruption styles. Nat Commun. 2018;9:2839 pubmed publisher
    ..This review evaluates the competing processes that lead to explosive and effusive eruptions of silicic magmas. Eruptive style depends on a set of feedback involving interrelated magmatic properties and processes...
  12. Bouvier L, Costa M, Connelly J, Jensen N, Wielandt D, Storey M, et al. Evidence for extremely rapid magma ocean crystallization and crust formation on Mars. Nature. 2018;558:586-589 pubmed publisher this time and survived for around 100 Myr before it was reworked, possibly by impacts4,5, to produce magmas from which the zircons crystallized...
  13. Hou T, Charlier B, Holtz F, Veksler I, Zhang Z, Thomas R, et al. Immiscible hydrous Fe-Ca-P melt and the origin of iron oxide-apatite ore deposits. Nat Commun. 2018;9:1415 pubmed publisher
    ..Here we report experiments on intermediate magmas that develop liquid immiscibility at 100 MPa, 1000-1040 °C, and oxygen fugacity conditions (fO2) ..
  14. Polacci M, Arzilli F, La Spina G, Le Gall N, Cai B, Hartley M, et al. Crystallisation in basaltic magmas revealed via in situ 4D synchrotron X-ray microtomography. Sci Rep. 2018;8:8377 pubmed publisher
    ..We use our observations to quantify disequilibrium crystallisation in basaltic magmas using an empirical model...
  15. Grosch E, Hazen R. Microbes, Mineral Evolution, and the Rise of Microcontinents-Origin and Coevolution of Life with Early Earth. Astrobiology. 2015;15:922-39 pubmed publisher
    ..These evolved magmas most likely included sialic or tonalitic sheets, felsic volcaniclastics, and minor rhyolitic intrusions emplaced ..
  16. Kyong Song R, Hammond J, Chol Nam K, Hyok K, Yong Gun Y, Gil Jong P, et al. Evidence for partial melt in the crust beneath Mt. Paektu (Changbaishan), Democratic People's Republic of Korea and China. Sci Adv. 2016;2:e1501513 pubmed publisher
    ..Paektu. This region of melt represents a potential source for magmas erupted in the last few thousand years and may be associated with an episode of volcanic unrest observed between ..
  17. Farris D, Cardona A, Montes C, Foster D, Jaramillo C. Magmatic evolution of Panama Canal volcanic rocks: A record of arc processes and tectonic change. PLoS ONE. 2017;12:e0176010 pubmed publisher
    ..present a world-class opportunity to examine the relationship between arc magmatism, tectonic forcing, wet and dry magmas, and volcanic structures...
  18. Pomonis P, Margellou A. Zipf's law for pore ranking and pore anisotropy. Phys Chem Chem Phys. 2017;19:17441-17448 pubmed publisher
    ..of magnitude, from nm pore sizes in laboratory-made materials, to cm pore sizes occurring in solidified volcanic magmas. Also it is demonstrated that for MCM-type materials with organized mesopores, the out-of-trend data in the Zipf ..
  19. Gardiner N, Hawkesworth C, Robb L, Whitehouse M, Roberts N, Kirkland C, et al. Contrasting Granite Metallogeny through the Zircon Record: A Case Study from Myanmar. Sci Rep. 2017;7:748 pubmed publisher
    ..2-7.7‰). Variations in zircon Hf and U/Yb reaffirm that tin belt magmas contain greater crustal contributions than copper arc rocks...
  20. Sarafian E, Gaetani G, Hauri E, Sarafian A. Experimental constraints on the damp peridotite solidus and oceanic mantle potential temperature. Science. 2017;355:942-945 pubmed publisher
    ..mantle rock upwelling beneath oceanic spreading centers causes it to exceed the melting point (solidus), producing magmas that ascend to form basaltic crust ~6 to 7 kilometers thick...
  21. Giuffrida M, Viccaro M, Ottolini L. Ultrafast syn-eruptive degassing and ascent trigger high-energy basic eruptions. Sci Rep. 2018;8:147 pubmed publisher
    ..gradients in plagioclase are capable of recording extremely short-lived processes associated with gas loss from magmas prior to extrusion at the surface...
  22. Mastelaro V, Zanotto E. X-ray Absorption Fine Structure (XAFS) Studies of Oxide Glasses-A 45-Year Overview. Materials (Basel). 2018;11: pubmed publisher
    ..of synthetic oxide-based glasses, as well as their important function in the formation of natural glasses and magmas, and in nucleation and crystallization...
  23. Berberich G, Schreiber U. GeoBioScience: Red Wood Ants as Bioindicators for Active Tectonic Fault Systems in the West Eifel (Germany). Animals (Basel). 2013;3:475-98 pubmed publisher
    ..current stress field with a NW-SE-trending main stress direction opens pathways for geogenic gases and potential magmas following the same orientation. At the same time, Variscan and Mesozoic fault zones are reactivated...
  24. Pagé L, Hattori K. Tracing halogen and B cycling in subduction zones based on obducted, subducted and forearc serpentinites of the Dominican Republic. Sci Rep. 2017;7:17776 pubmed publisher
    ..are important reservoirs of fluid-mobile elements in subduction zones, contributing to volatiles in arc magmas and their transport into the Earth's mantle...
  25. Blanco Montenegro I, Montesinos F, Arnoso J. Aeromagnetic anomalies reveal the link between magmatism and tectonics during the early formation of the Canary Islands. Sci Rep. 2018;8:42 pubmed publisher the central part of the Canary Archipelago which would have favoured the rapid ascent and emplacement of magmas during a time span from 0.5 to 1...
  26. Barboni M, Boehnke P, Schmitt A, Harrison T, Shane P, Bouvier A, et al. Warm storage for arc magmas. Proc Natl Acad Sci U S A. 2016;113:13959-13964 pubmed
    ..The tempo and magnitude of these eruptions depends on the physical conditions under which magmas are retained within the crust...
  27. Petrelli M, El Omari K, Spina L, Le Guer Y, La Spina G, Perugini D. Timescales of water accumulation in magmas and implications for short warning times of explosive eruptions. Nat Commun. 2018;9:770 pubmed publisher
    ..What are the timescales of H2O accumulation in crystallizing magmas? What are the ascent rates of water-rich residual melts leading to explosive eruptions? Here, we track the ..
  28. Ghosh D, Bajgain S, Mookherjee M, Karki B. Carbon-bearing silicate melt at deep mantle conditions. Sci Rep. 2017;7:848 pubmed publisher
    Knowledge about the incorporation and role of carbon in silicate magmas is crucial for our understanding of the deep mantle processes...
  29. Sokol A, Tomilenko A, Bul bak T, Palyanova G, Sokol I, Palyanov Y. Carbon and Nitrogen Speciation in N-poor C-O-H-N Fluids at 6.3 GPa and 1100-1400 °C. Sci Rep. 2017;7:706 pubmed publisher
    ..Oxidation of fluids strongly reduces the concentration of CH4 and bulk carbon. However, higher alkanes, alcohols, and carboxylic acids can resist oxidation and should remain stable in mantle hydrous magmas.
  30. Yaxley G, Berry A, Rosenthal A, Woodland A, Paterson D. Redox preconditioning deep cratonic lithosphere for kimberlite genesis - evidence from the central Slave Craton. Sci Rep. 2017;7:30 pubmed publisher
    ..silicate melts in the presence of diamond, a process proposed to be critical for "pre-conditioning" deep lithospheric mantle and rendering it suitable for later generation of kimberlites and other SiO2-undersaturated magmas.
  31. Luttinen A. Bilateral geochemical asymmetry in the Karoo large igneous province. Sci Rep. 2018;8:5223 pubmed publisher
    ..Variations in the relative abundance of Nb reveal emplacement of distinctive, Nb-undepleted and Nb-depleted magmas in the North Karoo and South Karoo sub-provinces, respectively, and clarify correlation between flood basalts and ..
  32. Mehawej C, Delahodde A, Legeai Mallet L, Delague V, Kaci N, Desvignes J, et al. The impairment of MAGMAS function in human is responsible for a severe skeletal dysplasia. PLoS Genet. 2014;10:e1004311 pubmed publisher
    ..mutation in the mitochondria-associated granulocyte macrophage colony stimulating factor-signaling gene (MAGMAS) in a novel and severe spondylodysplastic dysplasia...
  33. Tassara S, González Jiménez J, Reich M, Schilling M, Morata D, Begg G, et al. Plume-subduction interaction forms large auriferous provinces. Nat Commun. 2017;8:843 pubmed publisher
    ..fluids released during the Middle-Late Jurassic resulted in optimal conditions to produce the ore-forming magmas that generated the gold deposits...
  34. Tagliati F, Gentilin E, Buratto M, Molè D, degli Uberti E, Zatelli M. Magmas, a gene newly identified as overexpressed in human and mouse ACTH-secreting pituitary adenomas, protects pituitary cells from apoptotic stimuli. Endocrinology. 2010;151:4635-42 pubmed publisher
    ..We here report the identification of a cDNA, corresponding to Magmas gene (mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal ..
  35. Benson T, Coble M, Rytuba J, Mahood G. Lithium enrichment in intracontinental rhyolite magmas leads to Li deposits in caldera basins. Nat Commun. 2017;8:270 pubmed publisher
    ..preserved within intracontinental rhyolitic calderas formed on eruption and weathering of lithium-enriched magmas have the potential to host large lithium clay deposits...
  36. Pais J, Schilke B, Craig E. Reevaluation of the role of the Pam18:Pam16 interaction in translocation of proteins by the mitochondrial Hsp70-based import motor. Mol Biol Cell. 2011;22:4740-9 pubmed publisher
    ..Pam18 forms a heterodimer with the structurally related protein Pam16, via their J-type domains...
  37. Sinha D, Srivastava S, D Silva P. Functional Diversity of Human Mitochondrial J-proteins Is Independent of Their Association with the Inner Membrane Presequence Translocase. J Biol Chem. 2016;291:17345-59 pubmed publisher
    ..Both DnaJC15 and DnaJC19 formed two distinct subcomplexes with Magmas at the import channel...
  38. He D, Li D, Li C, Li Y, Mei Q. Neoproterozoic rifting in the Upper Yangtze Continental Block: Constraints from granites in the Well W117 borehole, South China. Sci Rep. 2017;7:12542 pubmed publisher
    ..Their parent magmas were formed in a low-temperature condition (831-650?°C) and finally emplaced at ca...
  39. Srivastava S, Sinha D, Saha P, Marthala H, D Silva P. Magmas functions as a ROS regulator and provides cytoprotection against oxidative stress-mediated damages. Cell Death Dis. 2014;5:e1394 pubmed publisher
    ..the present study, we have identified for the first time a component of mammalian protein translocation machinery Magmas to perform a critical ROS regulatory function...
  40. Ghosh D, Karki B. Transport properties of carbonated silicate melt at high pressure. Sci Adv. 2017;3:e1701840 pubmed publisher
    Carbon dioxide, generally considered as the second most abundant volatile component in silicate magmas, is expected to significantly influence various melt properties...
  41. Moosa S, Fano V, Obregon M, Altmuller J, Thiele H, Nurnberg P, et al. A novel homozygous PAM16 mutation in a patient with a milder phenotype and longer survival. Am J Med Genet A. 2016;170:2436-9 pubmed publisher
  42. Kendrick J, Lavallee Y, Mariani E, Dingwell D, Wheeler J, Varley N. Crystal plasticity as an indicator of the viscous-brittle transition in magmas. Nat Commun. 2017;8:1926 pubmed publisher
    Understanding the flow of multi-phase (melt, crystals and bubbles) magmas is of great importance for interpreting eruption dynamics...
  43. Le Losq C, Neuville D, Chen W, Florian P, Massiot D, Zhou Z, et al. Percolation channels: a universal idea to describe the atomic structure and dynamics of glasses and melts. Sci Rep. 2017;7:16490 pubmed publisher
    ..In alumino-silicate glasses and melts, extensively used in industry and representing most of the Earth magmas, metal ions compensate the electrical charge deficit of AlO4- tetrahedra, but until now ..
  44. Debret B, Sverjensky D. Highly oxidising fluids generated during serpentinite breakdown in subduction zones. Sci Rep. 2017;7:10351 pubmed publisher
    ..from the slab to the mantle wedge could therefore provide the oxidized source for the genesis of primary arc magmas that release gases to the atmosphere during volcanism...
  45. Brounce M, Stolper E, Eiler J. Redox variations in Mauna Kea lavas, the oxygen fugacity of the Hawaiian plume, and the role of volcanic gases in Earth's oxygenation. Proc Natl Acad Sci U S A. 2017;114:8997-9002 pubmed publisher
    ..We show that low-pressure degassing resulted in reduction of the fO2 of Mauna Kea magmas by more than an order of magnitude...
  46. Amoruso A, Crescentini L, D Antonio M, Acocella V. Thermally-assisted Magma Emplacement Explains Restless Calderas. Sci Rep. 2017;7:7948 pubmed publisher
    ..Flegrei caldera; moreover, it explains the crystallization, re-melting and mixing among compositionally distinct magmas recorded in young volcanic rocks...
  47. Flinders A, Shen Y. Seismic evidence for a possible deep crustal hot zone beneath Southwest Washington. Sci Rep. 2017;7:7400 pubmed publisher
    ..This hot zone may supply evolved magmas to Mounts St...
  48. Schusdziarra C, Blamowska M, Azem A, Hell K. Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria. Hum Mol Genet. 2013;22:1348-57 pubmed publisher
    ..We show that MCJ forms a stable subcomplex with a component of the mitochondrial import motor, MAGMAS, a protein overexpressed in cells treated with granulocyte-macrophage colony-stimulating factor and in prostate ..