PALB2

Summary

Gene Symbol: PALB2
Description: partner and localizer of BRCA2
Alias: FANCN, PNCA3, partner and localizer of BRCA2, mutant partner and localizer of BRCA2
Species: human
Products:     PALB2

Top Publications

  1. Slater E, Langer P, Niemczyk E, Strauch K, Butler J, Habbe N, et al. PALB2 mutations in European familial pancreatic cancer families. Clin Genet. 2010;78:490-4 pubmed publisher
    Recently, PALB2 was reported to be a new pancreatic cancer susceptibility gene as determined by exomic sequencing, as truncating PALB2 mutations were identified in 3 of 96 American patients with familial pancreatic cancer (FPC)...
  2. Dansonka Mieszkowska A, Kluska A, Moes J, Dabrowska M, Nowakowska D, Niwinska A, et al. A novel germline PALB2 deletion in Polish breast and ovarian cancer patients. BMC Med Genet. 2010;11:20 pubmed publisher
    b>PALB2 protein was recently identified as a partner of BRCA1 and BRCA2 which determines their proper function in DNA repair.
  3. Tischkowitz M, Capanu M, Sabbaghian N, Li L, Liang X, Vallée M, et al. Rare germline mutations in PALB2 and breast cancer risk: a population-based study. Hum Mutat. 2012;33:674-80 pubmed publisher
    Germline mutations in the PALB2 gene are associated with an increased risk of developing breast cancer but little is known about the frequencies of rare variants in PALB2 and the nature of the variants that influence risk...
  4. Dray E, Etchin J, Wiese C, Saro D, Williams G, Hammel M, et al. Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. Nat Struct Mol Biol. 2010;17:1255-9 pubmed publisher
    ..The tumor suppressors BRCA2 and PALB2 act together to deliver RAD51 to chromosomal lesions to initiate repair...
  5. Byrnes G, Southey M, Hopper J. Are the so-called low penetrance breast cancer genes, ATM, BRIP1, PALB2 and CHEK2, high risk for women with strong family histories?. Breast Cancer Res. 2008;10:208 pubmed publisher
    ..Several studies found that the frequencies of mutations in ATM, BRIP1, PALB2 and CHEK2 were many times greater for cases with a strong family history than for controls...
  6. Phuah S, Lee S, Kang P, Kang I, Yoon S, Thong M, et al. Prevalence of PALB2 mutations in breast cancer patients in multi-ethnic Asian population in Malaysia and Singapore. PLoS ONE. 2013;8:e73638 pubmed publisher
    The partner and localizer of breast cancer 2 (PALB2) is responsible for facilitating BRCA2-mediated DNA repair by serving as a bridging molecule, acting as the physical and functional link between the breast cancer 1 (BRCA1) and breast ..
  7. Xia B, Sheng Q, Nakanishi K, Ohashi A, Wu J, Christ N, et al. Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. Mol Cell. 2006;22:719-29 pubmed
    ..Described here is the identification of PALB2, a BRCA2 binding protein...
  8. Pylkäs K, Erkko H, Nikkilä J, Solyom S, Winqvist R. Analysis of large deletions in BRCA1, BRCA2 and PALB2 genes in Finnish breast and ovarian cancer families. BMC Cancer. 2008;8:146 pubmed publisher
    ..In addition, PALB2 has recently been identified as a breast cancer susceptibility gene in several populations...
  9. Reid S, Schindler D, Hanenberg H, Barker K, Hanks S, Kalb R, et al. Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer. Nat Genet. 2007;39:162-4 pubmed
    b>PALB2 was recently identified as a nuclear binding partner of BRCA2. Biallelic BRCA2 mutations cause Fanconi anemia subtype FA-D1 and predispose to childhood malignancies...

More Information

Publications67

  1. Tischkowitz M, Xia B, Sabbaghian N, Reis Filho J, Hamel N, Li G, et al. Analysis of PALB2/FANCN-associated breast cancer families. Proc Natl Acad Sci U S A. 2007;104:6788-93 pubmed
    ..Given its close relationship with BRCA2, PALB2 was sequenced in affected probands from 68 BRCA1/BRCA2-negative breast cancer families of Ashkenazi Jewish, French ..
  2. Chen P, Liang J, Wang Z, Zhou X, Chen L, Li M, et al. Association of common PALB2 polymorphisms with breast cancer risk: a case-control study. Clin Cancer Res. 2008;14:5931-7 pubmed publisher
    The PALB2 gene has an essential role in BRCA2-mediated DNA double-strand break repair and intra-S phase DNA damage checkpoint control, and its mutations are moderately associated with breast cancer susceptibility...
  3. Sy S, Huen M, Chen J. MRG15 is a novel PALB2-interacting factor involved in homologous recombination. J Biol Chem. 2009;284:21127-31 pubmed publisher
    b>PALB2 is an integral component of the BRCA complex important for recombinational DNA repair. However, exactly how this activity is regulated in vivo remains unexplored...
  4. Blanco A, de la Hoya M, Balmana J, Ramon Y Cajal T, Teulé A, Miramar M, et al. Detection of a large rearrangement in PALB2 in Spanish breast cancer families with male breast cancer. Breast Cancer Res Treat. 2012;132:307-15 pubmed publisher
    It has been demonstrated that monoallelic PALB2 (Partner and Localizer of BRCA2) gene mutations predispose to familial breast cancer...
  5. Pern F, Bogdanova N, Schürmann P, Lin M, Ay A, Langer F, et al. Mutation analysis of BRCA1, BRCA2, PALB2 and BRD7 in a hospital-based series of German patients with triple-negative breast cancer. PLoS ONE. 2012;7:e47993 pubmed publisher
    ..a hospital-based series of 40 German patients with TNBC for the presence of germ-line mutations in BRCA1, BRCA2, PALB2, and BRD7 genes...
  6. Hellebrand H, Sutter C, Honisch E, Gross E, Wappenschmidt B, Schem C, et al. Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer. Hum Mutat. 2011;32:E2176-88 pubmed publisher
    The Partner and Localizer of BRCA2 (PALB2) protein has been linked to Fanconi anemia and breast cancer predisposition...
  7. Erkko H, Dowty J, Nikkilä J, Syrjakoski K, Mannermaa A, Pylkäs K, et al. Penetrance analysis of the PALB2 c.1592delT founder mutation. Clin Cancer Res. 2008;14:4667-71 pubmed publisher
    b>PALB2 is a recently identified breast cancer susceptibility gene. We have previously identified in the Finnish population a PALB2 c.1592delT founder truncation mutation that is associated with an increased risk of breast cancer...
  8. Bogdanova N, Sokolenko A, Iyevleva A, Abysheva S, Blaut M, Bremer M, et al. PALB2 mutations in German and Russian patients with bilateral breast cancer. Breast Cancer Res Treat. 2011;126:545-50 pubmed publisher
    Since germline mutations in the PALB2 (Partner and Localizer of BRCA2) gene have been identified as breast cancer (BC) susceptibility alleles, the geographical spread and risks associated with PALB2 mutations are subject of intense ..
  9. Potapova A, Hoffman A, Godwin A, Al Saleem T, Cairns P. Promoter hypermethylation of the PALB2 susceptibility gene in inherited and sporadic breast and ovarian cancer. Cancer Res. 2008;68:998-1002 pubmed publisher
    The partner and localizer of BRCA2 (PALB2) gene was recently identified as a BRCA2-interacting protein and subsequently shown to be a Fanconi anemia gene (FANCN)...
  10. Ding Y, Steele L, Chu L, Kelley K, Davis H, John E, et al. Germline mutations in PALB2 in African-American breast cancer cases. Breast Cancer Res Treat. 2011;126:227-30 pubmed publisher
    ..Truncating germline mutations in PALB2 have been identified in approximately 1% of early-onset and/or familial breast cancer cases...
  11. Erkko H, Xia B, Nikkilä J, Schleutker J, Syrjakoski K, Mannermaa A, et al. A recurrent mutation in PALB2 in Finnish cancer families. Nature. 2007;446:316-9 pubmed
    ..Other relevant genes therefore remain to be discovered. Recently a new BRCA2-binding protein, PALB2, was identified...
  12. Xia B, Dorsman J, Ameziane N, de Vries Y, Rooimans M, Sheng Q, et al. Fanconi anemia is associated with a defect in the BRCA2 partner PALB2. Nat Genet. 2007;39:159-61 pubmed
    ..Here we show that a defect in the BRCA2-interacting protein PALB2 is associated with Fanconi anemia in an individual with a new subtype...
  13. Hofstatter E, Domchek S, Miron A, Garber J, Wang M, Componeschi K, et al. PALB2 mutations in familial breast and pancreatic cancer. Fam Cancer. 2011;10:225-31 pubmed publisher
    PALB2 (Partner And Localizer of BRCA2) binds to and co-localizes with BRCA2 in DNA repair. Germline mutations in PALB2 have been identified in approximately 1-2% of familial breast cancer and 3-4% of familial pancreatic cancer cases...
  14. Guenard F, Pedneault C, Ouellette G, Labrie Y, Simard J, Durocher F. Evaluation of the contribution of the three breast cancer susceptibility genes CHEK2, STK11, and PALB2 in non-BRCA1/2 French Canadian families with high risk of breast cancer. Genet Test Mol Biomarkers. 2010;14:515-26 pubmed publisher
    ..The PALB2/FANCN gene encodes a nuclear partner of BRCA2 and acts as a linker between BRCA1 and BRCA2...
  15. Stadler Z, Salo Mullen E, Sabbaghian N, Simon J, Zhang L, Olson S, et al. Germline PALB2 mutation analysis in breast-pancreas cancer families. J Med Genet. 2011;48:523-5 pubmed publisher
    Germline mutations in the PALB2 gene have been implicated in both breast cancer and pancreatic cancer susceptibility. The extent to which PALB2 mutations account for cancer susceptibility in breast-pancreas cancer families is unknown...
  16. Sy S, Huen M, Chen J. PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci U S A. 2009;106:7155-60 pubmed publisher
    ..Here, we report that PALB2, the partner and localizer of BRCA2, binds directly to BRCA1, and serves as the molecular scaffold in the formation of the BRCA1-PALB2-..
  17. Yang X, Jessop L, Myers T, Amundadottir L, Pfeiffer R, Wheeler W, et al. Lack of germline PALB2 mutations in melanoma-prone families with CDKN2A mutations and pancreatic cancer. Fam Cancer. 2011;10:545-8 pubmed publisher
    ..We evaluated a recently identified PC susceptibility gene PALB2 using both sequencing and tagging to determine whether PALB2 might explain part of the relationship between CDKN2A,..
  18. Casadei S, Norquist B, Walsh T, Stray S, Mandell J, Lee M, et al. Contribution of inherited mutations in the BRCA2-interacting protein PALB2 to familial breast cancer. Cancer Res. 2011;71:2222-9 pubmed publisher
    Inherited mutations in the BRCA2-interacting protein PALB2 are known to be associated with increased risks of developing breast cancer...
  19. Hayakawa T, Zhang F, Hayakawa N, Ohtani Y, Shinmyozu K, Nakayama J, et al. MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks. J Cell Sci. 2010;123:1124-30 pubmed publisher
    b>PALB2 physically and functionally connects the proteins encoded by the BRCA1 and BRCA2 breast and ovarian cancer genes into a DNA-damage-response network...
  20. Rahman N, Seal S, Thompson D, Kelly P, Renwick A, Elliott A, et al. PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene. Nat Genet. 2007;39:165-7 pubmed
    PALB2 interacts with BRCA2, and biallelic mutations in PALB2 (also known as FANCN), similar to biallelic BRCA2 mutations, cause Fanconi anemia...
  21. Wong M, Nordfors C, Mossman D, Pecenpetelovska G, Avery Kiejda K, Talseth Palmer B, et al. BRIP1, PALB2, and RAD51C mutation analysis reveals their relative importance as genetic susceptibility factors for breast cancer. Breast Cancer Res Treat. 2011;127:853-9 pubmed publisher
    ..In this study, BRIP1, PALB2, and RAD51C were sequenced for mutations as a result of previously being associated with breast cancer risk due to ..
  22. Cao A, Huang J, Hu Z, Li W, Ma Z, Tang L, et al. The prevalence of PALB2 germline mutations in BRCA1/BRCA2 negative Chinese women with early onset breast cancer or affected relatives. Breast Cancer Res Treat. 2009;114:457-62 pubmed publisher
    b>PALB2 has been recently identified as breast cancer susceptibility gene in western populations...
  23. Sy S, Huen M, Zhu Y, Chen J. PALB2 regulates recombinational repair through chromatin association and oligomerization. J Biol Chem. 2009;284:18302-10 pubmed publisher
    ..Here, we reveal novel properties of the BRCA2-associated protein PALB2 in the assembly of the recombinational DNA repair machinery at DNA damage sites...
  24. Papi L, Putignano A, Congregati C, Piaceri I, Zanna I, Sera F, et al. A PALB2 germline mutation associated with hereditary breast cancer in Italy. Fam Cancer. 2010;9:181-5 pubmed publisher
    Recently, it has been demonstrated that monoallelic PALB2 mutations predispose to familial breast cancer...
  25. Sabbaghian N, Kyle R, Hao A, Hogg D, Tischkowitz M. Mutation analysis of the PALB2 cancer predisposition gene in familial melanoma. Fam Cancer. 2011;10:315-7 pubmed publisher
    b>PALB2 is a breast and pancreas cancer susceptibility gene whose protein is closely associated with BRCA2 and is essential for BRCA2 anchorage to nuclear structures...
  26. Zhang F, Fan Q, Ren K, Andreassen P. PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2. Mol Cancer Res. 2009;7:1110-8 pubmed publisher
    ..We show here that PALB2 physically and functionally connects BRCA1 and BRCA2 into a DNA damage response network that also includes the ..
  27. Ding Y, Steele L, Kuan C, Greilac S, Neuhausen S. Mutations in BRCA2 and PALB2 in male breast cancer cases from the United States. Breast Cancer Res Treat. 2011;126:771-8 pubmed publisher
    ..Our objectives are to determine the frequency of pathogenic mutations in BRCA2 and PALB2 in MBC cases and to investigate the correlations between mutation status and cancer phenotypes...
  28. Adank M, van Mil S, Gille J, Waisfisz Q, Meijers Heijboer H. PALB2 analysis in BRCA2-like families. Breast Cancer Res Treat. 2011;127:357-62 pubmed publisher
    BRCA2 and PALB2 function together in the Fanconi anemia (FA)-Breast Cancer (BRCA) pathway. Mono-allelic and bi-allelic BRCA2 and PALB2 mutation carriers share many clinical characteristics...
  29. Sluiter M, Mew S, van Rensburg E. PALB2 sequence variants in young South African breast cancer patients. Fam Cancer. 2009;8:347-53 pubmed publisher
    PALB2 (partner and localizer of BRCA2) is a recently identified breast cancer susceptibility gene, in which mutations confer doubling of breast cancer risk with moderate to low penetrance...
  30. Garcia M, Fernandez V, Osorio A, Barroso A, Llort G, Lazaro C, et al. Analysis of FANCB and FANCN/PALB2 fanconi anemia genes in BRCA1/2-negative Spanish breast cancer families. Breast Cancer Res Treat. 2009;113:545-51 pubmed publisher
    Recent reports have shown that mutations in the FANCJ/BRIP1 and FANCN/PALB2 Fanconi Anemia (FA) genes confer a moderate breast cancer risk...
  31. Menzel T, Nähse Kumpf V, Kousholt A, Klein D, Lund Andersen C, Lees M, et al. A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance. EMBO Rep. 2011;12:705-12 pubmed publisher
    ..The checkpoint was also abrogated following depletion of PALB2, an interaction partner of BRCA2...
  32. Zheng Y, Zhang J, Niu Q, Huo D, Olopade O. Novel germline PALB2 truncating mutations in African American breast cancer patients. Cancer. 2012;118:1362-70 pubmed publisher
    It has been demonstrated that the partner and localizer of breast cancer 2 (PALB2) acts as a bridging molecule between the breast cancer 1 (BRCA1) and BRCA2 proteins and is responsible for facilitating BRCA2-mediated DNA repair...
  33. Oliver A, Swift S, Lord C, Ashworth A, Pearl L. Structural basis for recruitment of BRCA2 by PALB2. EMBO Rep. 2009;10:990-6 pubmed publisher
    ..Localization of BRCA2 to nuclear foci requires its association with the partner and localizer of BRCA2 (PALB2), mutations in which are associated with cancer predisposition, as well as subtype N of Fanconi ..
  34. Gunnarsson H, Arason A, Gillanders E, Agnarsson B, Johannesdottir G, Johannsson O, et al. Evidence against PALB2 involvement in Icelandic breast cancer susceptibility. J Negat Results Biomed. 2008;7:5 pubmed publisher
    Several mutations in the PALB2 gene (partner and localizer of BRCA2) have been associated with an increased risk of breast cancer, including a founder mutation, 1592delT, reported in Finnish breast cancer families...
  35. Catucci I, Milgrom R, Kushnir A, Laitman Y, Paluch Shimon S, Volorio S, et al. Germline mutations in BRIP1 and PALB2 in Jewish high cancer risk families. Fam Cancer. 2012;11:483-91 pubmed publisher
    Germline mutations in BRCA1 and BRCA2 account for ~30 % of inherited breast cancer. BRIP1 and PALB2 are likely genes for breast cancer susceptibility, based on their roles in maintaining cellular integrity...
  36. Blanco A, de la Hoya M, Osorio A, Diez O, Miramar M, Infante M, et al. Analysis of PALB2 gene in BRCA1/BRCA2 negative Spanish hereditary breast/ovarian cancer families with pancreatic cancer cases. PLoS ONE. 2013;8:e67538 pubmed publisher
    The PALB2 gene, also known as FANCN, forms a bond and co-localizes with BRCA2 in DNA repair. Germline mutations in PALB2 have been identified in approximately 1% of familial breast cancer and 3-4% of familial pancreatic cancer...
  37. Balia C, Sensi E, Lombardi G, Roncella M, Bevilacqua G, Caligo M. PALB2: a novel inactivating mutation in a Italian breast cancer family. Fam Cancer. 2010;9:531-6 pubmed publisher
    Rare germline monoallelic mutations in PALB2 confer a relative risk of breast cancer of 2 to 4-times...
  38. Southey M, Teo Z, Dowty J, Odefrey F, Park D, Tischkowitz M, et al. A PALB2 mutation associated with high risk of breast cancer. Breast Cancer Res. 2010;12:R109 pubmed publisher
    As a group, women who carry germline mutations in partner and localizer of breast cancer 2 susceptibility protein (PALB2) are at increased risk of breast cancer...
  39. Foulkes W, Ghadirian P, Akbari M, Hamel N, Giroux S, Sabbaghian N, et al. Identification of a novel truncating PALB2 mutation and analysis of its contribution to early-onset breast cancer in French-Canadian women. Breast Cancer Res. 2007;9:R83 pubmed
    b>PALB2 has recently been identified as a breast cancer susceptibility gene. PALB2 mutations are rare causes of hereditary breast cancer but may be important in countries such as Finland where a founder mutation is present...
  40. Heikkinen T, Kärkkäinen H, Aaltonen K, Milne R, Heikkila P, Aittomaki K, et al. The breast cancer susceptibility mutation PALB2 1592delT is associated with an aggressive tumor phenotype. Clin Cancer Res. 2009;15:3214-22 pubmed publisher
    To determine the effect of the breast cancer susceptibility mutation PALB2 1592delT on tumor phenotype and patient survival...
  41. Buisson R, Dion Côté A, Coulombe Y, Launay H, Cai H, Stasiak A, et al. Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination. Nat Struct Mol Biol. 2010;17:1247-54 pubmed publisher
    Inherited mutations in human PALB2 are associated with a predisposition to breast and pancreatic cancers. PALB2's tumor-suppressing effect is thought to be based on its ability to facilitate BRCA2's function in homologous recombination...
  42. Tischkowitz M, Sabbaghian N, Ray A, Lange E, Foulkes W, Cooney K. Analysis of the gene coding for the BRCA2-interacting protein PALB2 in hereditary prostate cancer. Prostate. 2008;68:675-8 pubmed publisher
    ..b>PALB2 is a recently identified breast cancer susceptibility gene whose protein is closely associated with BRCA2 and is ..
  43. Ghadirian P, Robidoux A, Zhang P, Royer R, Akbari M, Zhang S, et al. The contribution of founder mutations to early-onset breast cancer in French-Canadian women. Clin Genet. 2009;76:421-6 pubmed publisher
    ..We screened all 564 patients for nine founder mutations: four in BRCA1, three in BRCA2 and one each in PALB2 and CHEK2...
  44. Ghiorzo P, Pensotti V, Fornarini G, Sciallero S, Battistuzzi L, Belli F, et al. Contribution of germline mutations in the BRCA and PALB2 genes to pancreatic cancer in Italy. Fam Cancer. 2012;11:41-7 pubmed publisher
    ..Recently, PALB2 has been implicated in both PC and breast cancer (BC) susceptibility...
  45. Zhang F, Ma J, Wu J, Ye L, Cai H, Xia B, et al. PALB2 links BRCA1 and BRCA2 in the DNA-damage response. Curr Biol. 2009;19:524-9 pubmed publisher
    ..Here, we show that BRCA1 associates with BRCA2 through PALB2/FANCN, a major binding partner of BRCA2...
  46. Jones S, Hruban R, Kamiyama M, Borges M, Zhang X, Parsons D, et al. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science. 2009;324:217 pubmed publisher
    ..genes in a patient with familial pancreatic cancer, we identified a germline, truncating mutation in PALB2 that appeared responsible for this patient's predisposition to the disease...
  47. McInerney N, Miller N, Rowan A, Colleran G, Barclay E, Curran C, et al. Evaluation of variants in the CHEK2, BRIP1 and PALB2 genes in an Irish breast cancer cohort. Breast Cancer Res Treat. 2010;121:203-10 pubmed publisher
    It has been proposed that rare variants within the double strand break repair genes CHEK2, BRIP1 and PALB2 predispose to breast cancer...
  48. Antoniou A, Casadei S, Heikkinen T, Barrowdale D, Pylkäs K, Roberts J, et al. Breast-cancer risk in families with mutations in PALB2. N Engl J Med. 2014;371:497-506 pubmed publisher
    Germline loss-of-function mutations in PALB2 are known to confer a predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred by such mutations remains unknown.
  49. Gardini A, Baillat D, Cesaroni M, Shiekhattar R. Genome-wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co-activation. EMBO J. 2014;33:890-905 pubmed publisher
    Breast and ovarian cancer susceptibility genes BRCA1 and PALB2 have enigmatic roles in cellular growth and mammalian development...
  50. Wesoła M, Jeleń M. The risk of breast cancer due to PALB2 gene mutations. Adv Clin Exp Med. 2017;26:339-342 pubmed publisher
  51. Gravells P, Grant E, Smith K, James D, Bryant H. Specific killing of DNA damage-response deficient cells with inhibitors of poly(ADP-ribose) glycohydrolase. DNA Repair (Amst). 2017;52:81-91 pubmed publisher
    ..Here we use siRNA to show a synthetic lethal relationship between PARG and BRCA1, BRCA2, PALB2, FAM175A (ABRAXAS) and BARD1...
  52. Hasmad H, Lai K, Wen W, Park D, Nguyen Dumont T, Kang P, et al. Evaluation of germline BRCA1 and BRCA2 mutations in a multi-ethnic Asian cohort of ovarian cancer patients. Gynecol Oncol. 2016;141:318-322 pubmed publisher
    ..using targeted amplification and sequencing of the intron-exon junctions and exonic sequences of BRCA1, BRCA2, PALB2 and TP53...
  53. Ma J, Cai H, Wu T, Sobhian B, Huo Y, Alcivar A, et al. PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function. Mol Cell Biol. 2012;32:1506-17 pubmed publisher
    b>PALB2/FANCN is mutated in breast and pancreatic cancers and Fanconi anemia (FA)...
  54. Park J, Zhang F, Andreassen P. PALB2: the hub of a network of tumor suppressors involved in DNA damage responses. Biochim Biophys Acta. 2014;1846:263-75 pubmed publisher
    b>PALB2 was first identified as a partner of BRCA2 that mediates its recruitment to sites of DNA damage. PALB2 was subsequently found as a tumor suppressor gene...
  55. Silvestri V, Zelli V, Valentini V, Rizzolo P, Navazio A, Coppa A, et al. Whole-exome sequencing and targeted gene sequencing provide insights into the role of PALB2 as a male breast cancer susceptibility gene. Cancer. 2017;123:210-218 pubmed publisher
    ..WES in the family identified the partner and localizer of BRCA2 (PALB2) c...
  56. Fernandes P, Saam J, Peterson J, Hughes E, Kaldate R, Cummings S, et al. Comprehensive sequencing of PALB2 in patients with breast cancer suggests PALB2 mutations explain a subset of hereditary breast cancer. Cancer. 2014;120:963-7 pubmed publisher
    This study sought to determine the prevalence of PALB2 mutations in a cohort referred for diagnostic testing for hereditary breast cancer...
  57. Kim S, Jung S, Kim M, Han M, Park H, Jung E, et al. Genomic profiles of a hepatoblastoma from a patient with Beckwith-Wiedemann syndrome with uniparental disomy on chromosome 11p15 and germline mutation of APC and PALB2. Oncotarget. 2017;8:91950-91957 pubmed publisher
    ..5. We found germline 11p15.5 UPD as well as germline mutations of APC and PALB2 in the patient...
  58. Donenberg T, Ahmed H, Royer R, Zhang S, Narod S, George S, et al. A Survey of BRCA1, BRCA2, and PALB2 mutations in women with breast cancer in Trinidad and Tobago. Breast Cancer Res Treat. 2016;159:131-8 pubmed publisher
    ..We examined the prevalence of mutations in three susceptibility genes (BRCA1, BRCA2, and PALB2) in breast cancer patients in Trinidad and Tobago...