PAK5

Summary

Gene Symbol: PAK5
Description: p21 (RAC1) activated kinase 5
Alias: PAK7, serine/threonine-protein kinase PAK 5, PAK-5, PAK-7, p21 (RAC1) activated kinase 7, p21 protein (Cdc42/Rac)-activated kinase 7, p21(CDKN1A)-activated kinase 7, p21-activated kinase 5, p21-activated kinase 7, p21CDKN1A-activated kinase 7, protein kinase PAK5, serine/threonine-protein kinase PAK 7, serine/threonine-protein kinase PAK7
Species: human
Products:     PAK5

Top Publications

  1. Wang X, Cheng Q, Zhang S, Qian H, Wu J, Tian H, et al. PAK5-Egr1-MMP2 signaling controls the migration and invasion in breast cancer cell. Tumour Biol. 2013;34:2721-9 pubmed publisher
    ..As a recently identified member of the group B PAK family, the role of PAK5 in cancer is poorly understood...
  2. Cotteret S, Jaffer Z, Beeser A, Chernoff J. p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Mol Cell Biol. 2003;23:5526-39 pubmed
    b>Pak5 is the most recently identified and least understood member of the p21-activated kinase (Pak) family...
  3. Li D, Yao X, Zhang P. The overexpression of P21-activated kinase 5 (PAK5) promotes paclitaxel-chemoresistance of epithelial ovarian cancer. Mol Cell Biochem. 2013;383:191-9 pubmed publisher
    P21-activated kinase 5 (PAK5) is the recently identified member of the group II p21-activated kinases (PAKs) family, which is characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding domain and a carboxyl terminal ..
  4. Cotteret S, Chernoff J. Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties. Mol Cell Biol. 2006;26:3215-30 pubmed
    p21-activated kinase 5 (Pak5) is an effector for the small GTPase Cdc42, known to activate cell survival signaling pathways. Previously, we have shown that Pak5 localizes primarily to mitochondria...
  5. Gu J, Li K, Li M, Wu X, Zhang L, Ding Q, et al. A role for p21-activated kinase 7 in the development of gastric cancer. FEBS J. 2013;280:46-55 pubmed publisher
    ..b>PAK7 can promote neurite outgrowth, induce microtubule stabilization, and activate cell survival signaling pathways...
  6. Han Z, Wang X, Zhang S, Wu J, Qian H, Wen Y, et al. Downregulation of PAK5 inhibits glioma cell migration and invasion potentially through the PAK5-Egr1-MMP2 signaling pathway. Brain Tumor Pathol. 2014;31:234-41 pubmed publisher
    PAK5 (p21 activated kinase 5) is upregulated in human colorectal carcinoma cells and is a known tumor promoter in carcinogenesis of the colon...
  7. Pandey A, Dan I, Kristiansen T, Watanabe N, Voldby J, Kajikawa E, et al. Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain. Oncogene. 2002;21:3939-48 pubmed
    ..We have cloned a novel human PAK family kinase that has been designated as PAK5. PAK5 contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain at ..
  8. Dan C, Nath N, Liberto M, Minden A. PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells. Mol Cell Biol. 2002;22:567-77 pubmed
    We have characterized a new member of the mammalian PAK family of serine/threonine kinases, PAK5, which is a novel target of the Rho GTPases Cdc42 and Rac...
  9. Gong W, An Z, Wang Y, Pan X, Fang W, Jiang B, et al. P21-activated kinase 5 is overexpressed during colorectal cancer progression and regulates colorectal carcinoma cell adhesion and migration. Int J Cancer. 2009;125:548-55 pubmed publisher
    P21-activated kinase 5 (PAK5) is the recently identified member of the group B p21-activated kinase (PAK) family which are effectors of the small GTPase Cdc42 and Rac1, known to regulate cell motility and activate cell-survival signaling ..

More Information

Publications53

  1. Quan L, Cheng Z, Dai Y, Jiao Y, Shi J, Fu L. Prognostic significance of PAK family kinases in acute myeloid leukemia. Cancer Gene Ther. 2019;: pubmed publisher
    ..In the chemotherapy-only group, high PAK3 and PAK7 expression were both bound up with poor EFS and OS (all P < 0.05)...
  2. Li K, Xu X, He Y, Tian Y, Pan W, Xu L, et al. P21-activated kinase 7 (PAK7) interacts with and activates Wnt/?-catenin signaling pathway in breast cancer. J Cancer. 2018;9:1821-1835 pubmed publisher
    ..However, the mechanism of PAK7 involving in the occurrence and progression of breast cancer is not yet fully understood...
  3. Huo F, Pan Y, Li T, Mou J, Pei D. PAK5 promotes the migration and invasion of cervical cancer cells by phosphorylating SATB1. Cell Death Differ. 2018;: pubmed publisher
    p21-activated kinase 5 (PAK5) is involved in several oncogenic signaling pathways and its amplification or overexpression has been found in various types of cancer; however, the pathophysiologic role of PAK5 in cervical cancer (CC) ..
  4. de Oliveira Furo I, Kretschmer R, O Brien P, Pereira J, del Valle Garnero A, Gunski R, et al. Chromosome Painting in Neotropical Long- and Short-Tailed Parrots (Aves, Psittaciformes): Phylogeny and Proposal for a Putative Ancestral Karyotype for Tribe Arini. Genes (Basel). 2018;9: pubmed publisher
    ..the results with the putative avian ancestral karyotype (PAK) showed fusions in PFR of PAK1p/PAK4q (PFR1) and PAK6/PAK7 (PFR6) with a paracentric inversion in PFR6...
  5. Fadista J, Vikman P, Laakso E, Mollet I, Esguerra J, Taneera J, et al. Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism. Proc Natl Acad Sci U S A. 2014;111:13924-9 pubmed publisher
    ..ecto (NT5E), transmembrane emp24 protein transport domain containing 6 (TMED6), and p21 protein activated kinase 7 (PAK7) in INS1 cells resulted in reduced glucose-stimulated insulin secretion...
  6. Szmida E, Karpiński P, Leszczynski P, Sedziak T, Kielan W, Ostasiewicz P, et al. Aberrant methylation of ERBB pathway genes in sporadic colorectal cancer. J Appl Genet. 2015;56:185-92 pubmed publisher
    ..After careful re-analysis of published methylation and expression data, we conclude that methylation of ERBB4, PAK7 and PIK3CD has no functional role in CRC carcinogenesis...
  7. Zhang D, Zhang J, Mao L, Wu J, Cao W, Zheng J, et al. p21-Activated kinase 5 affects cisplatin-induced apoptosis and proliferation in hepatocellular carcinoma cells. Tumour Biol. 2015;36:3685-91 pubmed publisher
    p21-Activated kinase 5 (PAK5) is the last identified member of the PAK family. The PAKs are highly conserved serine/threonine and effector proteins for Cdc42 and Rac and are essential in regulating cell motility and survival...
  8. Ha B, Morse E, Turk B, Boggon T. Signaling, Regulation, and Specificity of the Type II p21-activated Kinases. J Biol Chem. 2015;290:12975-83 pubmed publisher
    ..PAKs are subdivided into two groups: type I PAKs (PAK1, PAK2, and PAK3) and type II PAKs (PAK4, PAK5, and PAK6)...
  9. Wang Q, Lv H, Lv W, Shi M, Zhang M, Luan M, et al. Genome-wide haplotype association study identifies BLM as a risk gene for prostate cancer in Chinese population. Tumour Biol. 2015;36:2703-7 pubmed publisher
    ..susceptibility genes, we found that seven novel PC susceptibility genes including BLM, RPS6KA2, FRK, ERBB4, RBL1, PAK7, and ERBB2IP. Among the seven genes, BLM gene ranked first (P = 1.89E-04)...
  10. Li Y, Ke Q, Shao Y, Zhu G, Li Y, Geng N, et al. GATA1 induces epithelial-mesenchymal transition in breast cancer cells through PAK5 oncogenic signaling. Oncotarget. 2015;6:4345-56 pubmed
    ..Moreover, GATA1 is a new substrate of p21-activated kinase 5 (PAK5), which is phosphorylated on serine 161 and 187 (S161 and S187)...
  11. Davis L, Meyer K, Schindler E, Beck J, Rudd D, Grundstad A, et al. Copy number variations and primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2011;52:7122-33 pubmed publisher
    ..This set included CNVs on 5q23.1 (DMXL1, DTWD2), 20p12 (PAK7), 12q14 (C12orf56, XPOT, TBK1, and RASSF3), 12p13.33 (TULP3), and 10q34.21 (PAX2), among others...
  12. Bergeron V, Ghislain J, Poitout V. The P21-activated kinase PAK4 is implicated in fatty-acid potentiation of insulin secretion downstream of free fatty acid receptor 1. Islets. 2016;8:157-164 pubmed
    ..knockdown of PAK4 in INS832/13 cells abrogated the potentiation of insulin secretion by oleate, whereas PAK7 knockdown had no effect...
  13. Amano M, Hamaguchi T, Shohag M, Kozawa K, Kato K, Zhang X, et al. Kinase-interacting substrate screening is a novel method to identify kinase substrates. J Cell Biol. 2015;209:895-912 pubmed publisher
    ..The KISS method was also applied to additional kinases, including PKA, MAPK1, CDK5, CaMK1, PAK7, PKN, LYN, and FYN, and a lot of candidate substrates and their phosphorylation sites were determined, most of ..
  14. Morse E, Sun X, Olberding J, Ha B, Boggon T, Calderwood D. PAK6 targets to cell-cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape. J Cell Sci. 2016;129:380-93 pubmed publisher
    ..Finally, we demonstrate that all type II PAKs (PAK4, PAK5 and PAK6) target to cell-cell adhesions, albeit to differing extents, but PAK1 (a type I PAK) does not...
  15. Zheng J, Li X, Wang P, Liu X, Xue Y, Hu Y, et al. CRNDE affects the malignant biological characteristics of human glioma stem cells by negatively regulating miR-186. Oncotarget. 2015;6:25339-55 pubmed publisher
    ..And CRNDE decreased the expression levels of XIAP and PAK7 by binding to miR-186 and negatively regulating it...
  16. Zhang Y, Cheng F, Zhou X, Qi Y, Hou P, Zhao M, et al. Detecting Genetic Associations between ATG5 and Lupus Nephritis by trans-eQTL. J Immunol Res. 2015;2015:153132 pubmed publisher
    ..05), including ANKRD50 rs17008504, AGA rs2271100, PAK7 rs6056923, and TET2 rs1391441, while seven other trans-eSNPs showed marginal significant associations (0...
  17. Zhan L, Pan Y, Chen L, Chen Z, Zhang H, Sun C. MicroRNA-526a targets p21-activated kinase 7 to inhibit tumorigenesis in hepatocellular carcinoma. Mol Med Rep. 2017;16:837-844 pubmed publisher
    ..Using overlapping strategies, p21‑activated kinase 7 (PAK7) was predicted to be a target for miR‑526a, and this was verified experimentally...
  18. He S, Feng M, Liu M, Yang S, Yan S, Zhang W, et al. P21-activated kinase 7 mediates cisplatin-resistance of esophageal squamous carcinoma cells with Aurora-A overexpression. PLoS ONE. 2014;9:e113989 pubmed publisher
    ..By using an apoptosis array, we identified a downstream gene, p21-activated kinase 7 (PAK7). PAK7 was upregulated by Aurora-A overexpression at both mRNA and protein levels...
  19. del Peso L, Gonzalez Garcia M, Page C, Herrera R, Nunez G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science. 1997;278:687-9 pubmed
    ..Thus, the proapoptotic function of BAD is regulated by the PI 3-kinase-Akt pathway. ..
  20. Gu X, Wang C, Wang X, Ma G, Li Y, Cui L, et al. Efficient inhibition of human glioma development by RNA interference-mediated silencing of PAK5. Int J Biol Sci. 2015;11:230-7 pubmed publisher
    ..The identification of a novel, effective target protein in gliomas is of great interest. We found that PAK5 was highly expressed in the tumor tissues of glioma patients and human glioma cell lines...
  21. He S, Liu M, Zhang W, Xu N, Zhu H. Over expression of p21-activated kinase 7 associates with lymph node metastasis in esophageal squamous cell cancers. Cancer Biomark. 2016;16:203-9 pubmed publisher
    ..In 85 samples, 44 (51.8%) samples showed strong expression and expression of PAK7 was significantly correlated with lymph node stage (p= 0.013) and TNM stage (p= 0.041)...
  22. Li C, Chen J, Wang Y, Song G, Xiao C, Yan D, et al. High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma. Oncotarget. 2016;7:46042-46055 pubmed publisher
    P21 protein (Cdc42/Rac)-activated kinase 7 (PAK7) can promote neurite outgrowth, induce microtubule stabilization, and activate cell survival signaling pathways...
  23. Tan Y, Demeter M, Ruan H, Comb M. BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival. J Biol Chem. 2000;275:25865-9 pubmed
    ..RSK1 phosphorylates BAD at both Ser-112 and Ser-155 and rescues BAD-mediated cell death in a manner dependent upon phosphorylation at both sites. ..
  24. Jaffer Z, Chernoff J. p21-activated kinases: three more join the Pak. Int J Biochem Cell Biol. 2002;34:713-7 pubmed
    ..Here we summarize recent findings that shed light on the newly recognized Group II Paks (Pak4, Pak5, Pak6) and review both similarities and differences between kinases of the two Pak subgroups.
  25. Fawdar S, Trotter E, Li Y, Stephenson N, Hanke F, Marusiak A, et al. Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer. Proc Natl Acad Sci U S A. 2013;110:12426-31 pubmed publisher
    ..we have identified three kinases with gain-of-function mutations in lung cancer, namely FGFR4, MAP3K9, and PAK5. Mutations in these kinases are activating toward the ERK pathway, and targeted depletion of the mutated kinases ..
  26. Ismail A, Oskay Halacli S, Babteen N, De Piano M, Martin T, Jiang W, et al. PAK5 mediates cell: cell adhesion integrity via interaction with E-cadherin in bladder cancer cells. Biochem J. 2017;474:1333-1346 pubmed publisher
    ..in a panel of bladder cancer cell lines correlated with the presence of cell:cell junctions and the level of PAK5 expression...
  27. Matenia D, Griesshaber B, Li X, Thiessen A, Johne C, Jiao J, et al. PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin. Mol Biol Cell. 2005;16:4410-22 pubmed
    ..Here we report that MARK2 is negatively regulated by PAK5, a neuronal member of the p21-activated kinase family...
  28. Morris D, Pearson R, Cormican P, Kenny E, O Dushlaine C, Perreault L, et al. An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis. Hum Mol Genet. 2014;23:3316-26 pubmed publisher
    ..and sequencing, we identified a tandem ~149 kb duplication overlapping the gene p21 Protein-Activated Kinase 7 (PAK7, also called PAK5) which was in linkage disequilibrium with local haplotypes (P = 2...
  29. Li Y, Rowland C, Xiromerisiou G, Lagier R, Schrodi S, Dradiotis E, et al. Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease. PLoS ONE. 2008;3:e2707 pubmed publisher
    ..Together, these results challenge the robustness of the reported panel of genetic markers to predict PD risk in particular and a role of the axon guidance pathway in PD genetics in general. ..
  30. Han K, Zhou Y, Gan Z, Qi W, Zhang J, Fen T, et al. p21-activated kinase 7 is an oncogene in human osteosarcoma. Cell Biol Int. 2014;38:1394-402 pubmed publisher
    p21-activated kinase 7 (PAK7), also named as PAK5, is a member of Rac/Cdc42-associated Ser/Thr protein kinases. It is overexpressed in some types of cancer such as colorectal and pancreatic cancers...
  31. Lizcano J, Morrice N, Cohen P. Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155. Biochem J. 2000;349:547-57 pubmed
  32. Song X, Xie Y, Liu Y, Shao M, Yang W. MicroRNA-492 overexpression exerts suppressive effects on the progression of osteosarcoma by targeting PAK7. Int J Mol Med. 2017;40:891-897 pubmed publisher
    ..p21-activated kinase (PAK7) was identified as the putative target of miR‑492 in OS, and we further found a significantly inverse ..
  33. Amado Azevedo J, Reinhard N, van Bezu J, de Menezes R, van Beusechem V, van Nieuw Amerongen G, et al. A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity. Sci Rep. 2017;7:10132 pubmed publisher
    ..GAP SYDE1 is part of a Cdc42-centered signaling unit, also comprising the Cdc42-GEF FARP1 and the Cdc42 effector PAK7 which controls the integrity of the endothelial barrier...
  34. Pan Y, Wei L, Wu X, Huo F, Mou J, Pei D. MiR-106a-5p inhibits the cell migration and invasion of renal cell carcinoma through targeting PAK5. Cell Death Dis. 2017;8:e3155 pubmed publisher
    ..Mechanistic studies demonstrated that miR-106a-5p directly bound to the 3'-UTR of the PAK5 mRNA and mediated a decrease in the protein expression of PAK5...
  35. Zhao M, Rabieifar P, Costa T, Zhuang T, Minden A, Lohr M, et al. Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development. Sci Rep. 2017;7:7031 pubmed publisher
    ..gene depletion of PAK1 or PAK3 caused functional deficits in the mouse pancreas, while gene depletion of PAK5 or PAK6 did not, we asked if PAK4 might have a functional role in pancreas development...
  36. Tabanifar B, Zhao Z, Manser E. PAK5 is auto-activated by a central domain that promotes kinase oligomerization. Biochem J. 2016;473:1777-89 pubmed publisher
    ..The group II kinases PAK4 and PAK5 are considered significant therapeutic targets in cancer...
  37. Cau J, Faure S, Comps M, Delsert C, Morin N. A novel p21-activated kinase binds the actin and microtubule networks and induces microtubule stabilization. J Cell Biol. 2001;155:1029-42 pubmed
    ..In transfected cells, X-PAK5 promotes the formation of stabilized MTs that are associated in bundles and interferes with MTs dynamics, slowing ..
  38. Zhu G, Li X, Guo B, Ke Q, Dong M, Li F. PAK5-mediated E47 phosphorylation promotes epithelial-mesenchymal transition and metastasis of colon cancer. Oncogene. 2016;35:1943-54 pubmed publisher
    The p21-activated kinase 5 (PAK5) is overexpressed in advanced cancer and the transcription factor E47 is a direct repressor of E-cadherin and inducer of epithelial-mesenchymal transition (EMT)...
  39. Zhang Y, Huo F, Wei L, Gong C, Pan Y, Mou J, et al. PAK5-mediated phosphorylation and nuclear translocation of NF-?B-p65 promotes breast cancer cell proliferation in vitro and in vivo. J Exp Clin Cancer Res. 2017;36:146 pubmed publisher
    ..Growing evidence suggest that the signal pathways of p21cdc42/rac1-activated kinase 5 (PAK5) have been found in various tumor progression, however, the role of PAK5 in breast cancer remains largely unclear...
  40. Wells C, Jones G. The emerging importance of group II PAKs. Biochem J. 2010;425:465-73 pubmed publisher
    ..Whereas much is known about group I PAKs, less is known about the more recently discovered PAK4, PAK5 and PAK6...
  41. Wong L, Reynolds A, Dissanayaka N, Minden A. p120-catenin is a binding partner and substrate for Group B Pak kinases. J Cell Biochem. 2010;110:1244-54 pubmed publisher
    b>Pak5 is a member of the Group B p21-activated kinases, which are effectors of the Rho family GTPases Cdc42 and Rac...
  42. Zhai J, Qu S, Li X, Zhong J, Chen X, Qu Z, et al. miR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma. Biochem Biophys Res Commun. 2015;464:161-7 pubmed publisher
    ..revealed that miR-129 suppressed cell proliferation and invasion by targeting the 3'-untranslated region of PAK5, as well as miR-129 silencing up-regulated PAK5 expression...
  43. Wen Y, Zheng J, Pei D. An oncogenic kinase: putting PAK5 forward. Expert Opin Ther Targets. 2014;18:807-15 pubmed publisher
    Overexpression of p21-activated kinase 5 (PAK5) is discovered in many tumors, probably due to its regulation in cytoskeleton, antiapoptosis and proliferation...
  44. Scheid M, Schubert K, Duronio V. Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase. J Biol Chem. 1999;274:31108-13 pubmed
    ..These results demonstrate for the first time in mammalian cells the involvement of the Ras-MAPK pathway in the phosphorylation of Bad and the regulation of its function. ..