Gene Symbol: PAFAH2
Description: platelet activating factor acetylhydrolase 2
Alias: HSD-PLA2, platelet-activating factor acetylhydrolase 2, cytoplasmic, SD-PLA2, platelet-activating factor acetylhydrolase 2, 40kDa, serine-dependent phospholipase A2
- Rice S, Southan C, Boyd H, Terrett J, Macphee C, Moores K, et al. Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor. Biochem J. 1998;330 ( Pt 3):1309-15 pubmedUsing expressed sequence tag (EST) homology screening, a new human serine dependent phospholipase A2 (HSD-PLA2) was identified that has 40% amino acid identity with human low density lipoprotein-associated phospholipase A2 (LDL-PLA2)...
- Min J, Wilder C, Aoki J, Arai H, Inoue K, Paul L, et al. Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme. Biochemistry. 2001;40:4539-49 pubmed
- Hattori K, Adachi H, Matsuzawa A, Yamamoto K, Tsujimoto M, Aoki J, et al. cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase. J Biol Chem. 1996;271:33032-8 pubmed
- Marques M, Pei Y, Southall M, Johnston J, Arai H, Aoki J, et al. Identification of platelet-activating factor acetylhydrolase II in human skin. J Invest Dermatol. 2002;119:913-9 pubmed
- Schmidt E, Koenig W, Khuseyinova N, Christensen J. Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids. Atherosclerosis. 2008;196:420-4 pubmed..The results support the view that Lp-PLA(2) may relate to CAD and that intake of marine n-3 fatty acids might reduce plasma Lp-PLA(2) suggesting another mechanism by which n-3 fatty acids could reduce the risk of cardiovascular disease. ..
- Monillas E, Caplan J, ThÃ©venin A, Bahnson B. Oligomeric state regulated trafficking of human platelet-activating factor acetylhydrolase type-II. Biochim Biophys Acta. 2015;1854:469-75 pubmed publisher..It is hypothesized that the balance between monomer and dimer serves as a regulatory mechanism of a PAFAH-II oxidative stress response. ..
- Moschos M, Pantazis P, Gatzioufas Z, Panos G, Gazouli M, Nitoda E, et al. "Association between platelet activating factor acetylhydrolase and diabetic retinopathy: Does inflammation affect the retinal status?". Prostaglandins Other Lipid Mediat. 2016;122:69-72 pubmed publisher..114 Î¼mol/min/ml, post-hoc Bonferroni comparison test: p<0.0001) and to NPDR group (0.147 Î¼mol/min/ml, post-hoc Bonferroni comparison test: p=0.012). The activity of PAF-AH in the plasma increases in parallel with DR severity. ..
- Stafforini D, McIntyre T, Zimmerman G, Prescott S. Platelet-activating factor acetylhydrolases. J Biol Chem. 1997;272:17895-8 pubmed
- Unno N, Sakaguchi T, Nakamura T, Yamamoto N, Sugatani J, Miwa M, et al. A single nucleotide polymorphism in the plasma PAF acetylhydrolase gene and risk of atherosclerosis in Japanese patients with peripheral artery occlusive disease. J Surg Res. 2006;134:36-43 pubmed..5 (6.0-40.3) compared with normal genotype and normal lipid level. The plasma PAF-AH gene polymorphism and hypercholesterolemia may interact and increase the risk of atherosclerosis. ..
- Umemura K, Kato I, Hirashima Y, Ishii Y, Inoue T, Aoki J, et al. Neuroprotective role of transgenic PAF-acetylhydrolase II in mouse models of focal cerebral ischemia. Stroke. 2007;38:1063-8 pubmed..1+/-16.9%; hippocampus, 58.9+/-15.3%). These results indicate that PAF-AH II exerts strong neuroprotective effects against ischemic injury and suggest a possibility for clinical use of this enzyme in cerebral ischemia. ..