PAFAH2

Summary

Gene Symbol: PAFAH2
Description: platelet activating factor acetylhydrolase 2
Alias: HSD-PLA2, platelet-activating factor acetylhydrolase 2, cytoplasmic, SD-PLA2, platelet-activating factor acetylhydrolase 2, 40kDa, serine-dependent phospholipase A2
Species: human

Top Publications

  1. pmc Oligomeric state regulated trafficking of human platelet-activating factor acetylhydrolase type-II
    Elizabeth S Monillas
    Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA
    Biochim Biophys Acta 1854:469-75. 2015
  2. doi "Association between platelet activating factor acetylhydrolase and diabetic retinopathy: Does inflammation affect the retinal status?"
    Marilita M Moschos
    University Eye Clinic, General Hospital of Athens G Gennimatas, Greece Electronic address
    Prostaglandins Other Lipid Mediat 122:69-72. 2016
  3. pmc Oxidatively truncated phospholipids are required agents of tumor necrosis factor α (TNFα)-induced apoptosis
    Calivarathan Latchoumycandane
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    J Biol Chem 287:17693-705. 2012
  4. ncbi cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase
    K Hattori
    Department of Health Chemistry, Faculty of Pharmaceutical Sciences, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113, Japan
    J Biol Chem 271:33032-8. 1996
  5. ncbi Platelet-activating factor acetylhydrolases
    D M Stafforini
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 272:17895-8. 1997
  6. pmc Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor
    S Q Rice
    Department of Biopharmaceutical Research U K, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park North, Harlow, Essex, CM19 5AW, U K
    Biochem J 330:1309-15. 1998
  7. ncbi Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme
    J H Min
    Department of Biochemistry and Chemistry, University of Washington, Seattle, Washington 98195, USA
    Biochemistry 40:4539-49. 2001
  8. ncbi Identification of platelet-activating factor acetylhydrolase II in human skin
    Mariangela Marques
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, U S A
    J Invest Dermatol 119:913-9. 2002
  9. ncbi A single nucleotide polymorphism in the plasma PAF acetylhydrolase gene and risk of atherosclerosis in Japanese patients with peripheral artery occlusive disease
    Naoki Unno
    Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Surg Res 134:36-43. 2006
  10. ncbi Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids
    Erik Berg Schmidt
    Department of Cardiology, Center for Cardiovascular Research, Aalborg Hospital, Arhus University Hospitals, Sdr Skovvej 15, 9100 Aalborg, Denmark
    Atherosclerosis 196:420-4. 2008

Scientific Experts

  • Marilita M Moschos
  • N Unno
  • E B Schmidt
  • D M Stafforini
  • Nozomu Kono
  • Elizabeth S Monillas
  • Hiroyuki Arai
  • Junken Aoki
  • Takao Inoue
  • Calivarathan Latchoumycandane
  • Alexander Adibekian
  • Kimiko Umemura
  • Jeffrey L Caplan
  • Anastasia F Thévenin
  • Brian J Bahnson
  • Mariangela Marques
  • Thomas M McIntyre
  • Gopal K Marathe
  • J H Min
  • Renliang Zhang
  • Sherry Niessen
  • Chu Wang
  • Brent R Martin
  • Daniel A Bachovchin
  • Heather Hoover
  • Ku Lung Hsu
  • Benjamin F Cravatt
  • Hiroyuki Itabe
  • Hiroyuki Sato
  • Tomokazu Matsusue
  • Yasukazu Yoshida
  • Etsuo Niki
  • J Aoki
  • Ichiro Kato
  • K Inoue
  • Koichi Hiraga
  • Shunro Endo
  • Masaya Oda
  • Yoko Ishii
  • Nakamasa Hayashi
  • Hideo Hamada
  • Takeshi Oya
  • H Arai
  • Yutaka Hirashima
  • Hiroyuki Kinouchi
  • S Q Rice
  • Yong Pei
  • Jeffrey B Travers
  • Christos C Zouboulis
  • Holger Seltmann
  • John M Johnston
  • Michael D Southall
  • K Hattori
  • C Wilder
  • L Paul
  • M H Gelb
  • J A Terrett
  • I S Gloger
  • H F Boyd
  • D G Tew
  • C H Macphee
  • K Moores
  • C Southan
  • K Yamamoto
  • A Matsuzawa
  • M Hattori
  • H Adachi
  • M Tsujimoto

Detail Information

Publications13

  1. pmc Oligomeric state regulated trafficking of human platelet-activating factor acetylhydrolase type-II
    Elizabeth S Monillas
    Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA
    Biochim Biophys Acta 1854:469-75. 2015
    ..It is hypothesized that the balance between monomer and dimer serves as a regulatory mechanism of a PAFAH-II oxidative stress response. ..
  2. doi "Association between platelet activating factor acetylhydrolase and diabetic retinopathy: Does inflammation affect the retinal status?"
    Marilita M Moschos
    University Eye Clinic, General Hospital of Athens G Gennimatas, Greece Electronic address
    Prostaglandins Other Lipid Mediat 122:69-72. 2016
    ..To assess the role of plasma platelet activating factor acetylhydrolase (PAF-AH) in pathogenesis and progression of diabetic retinopathy (DR)...
  3. pmc Oxidatively truncated phospholipids are required agents of tumor necrosis factor α (TNFα)-induced apoptosis
    Calivarathan Latchoumycandane
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    J Biol Chem 287:17693-705. 2012
    ..Truncated phospholipids were essential elements of TNFα-induced apoptosis because overexpression of PAFAH2 (a phospholipase A(2) that selectively hydrolyzes truncated phospholipids) blocked TNFα-induced Az-PC ..
  4. ncbi cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase
    K Hattori
    Department of Health Chemistry, Faculty of Pharmaceutical Sciences, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113, Japan
    J Biol Chem 271:33032-8. 1996
    ....
  5. ncbi Platelet-activating factor acetylhydrolases
    D M Stafforini
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 272:17895-8. 1997
  6. pmc Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor
    S Q Rice
    Department of Biopharmaceutical Research U K, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park North, Harlow, Essex, CM19 5AW, U K
    Biochem J 330:1309-15. 1998
    Using expressed sequence tag (EST) homology screening, a new human serine dependent phospholipase A2 (HSD-PLA2) was identified that has 40% amino acid identity with human low density lipoprotein-associated phospholipase A2 (LDL-PLA2)...
  7. ncbi Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme
    J H Min
    Department of Biochemistry and Chemistry, University of Washington, Seattle, Washington 98195, USA
    Biochemistry 40:4539-49. 2001
    ....
  8. ncbi Identification of platelet-activating factor acetylhydrolase II in human skin
    Mariangela Marques
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, U S A
    J Invest Dermatol 119:913-9. 2002
    ....
  9. ncbi A single nucleotide polymorphism in the plasma PAF acetylhydrolase gene and risk of atherosclerosis in Japanese patients with peripheral artery occlusive disease
    Naoki Unno
    Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Surg Res 134:36-43. 2006
    ..The objective of this study was to assess the joint effect of the polymorphism and hypercholesterolemia on risk of atherosclerosis...
  10. ncbi Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids
    Erik Berg Schmidt
    Department of Cardiology, Center for Cardiovascular Research, Aalborg Hospital, Arhus University Hospitals, Sdr Skovvej 15, 9100 Aalborg, Denmark
    Atherosclerosis 196:420-4. 2008
    ..The results support the view that Lp-PLA(2) may relate to CAD and that intake of marine n-3 fatty acids might reduce plasma Lp-PLA(2) suggesting another mechanism by which n-3 fatty acids could reduce the risk of cardiovascular disease...
  11. ncbi Neuroprotective role of transgenic PAF-acetylhydrolase II in mouse models of focal cerebral ischemia
    Kimiko Umemura
    Department of Neurosurgery, University of Toyama Faculty of Medicine, Toyama, Japan
    Stroke 38:1063-8. 2007
    ..We examined whether PAF-AH II can rescue cerebral neurons against ischemic insults...
  12. ncbi Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phospholipids in vivo
    Nozomu Kono
    Graduate School of Pharmaceutical Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 283:1628-36. 2008
    ..In this study we investigated the functions of PAF-AH (II) by generating PAF-AH (II)-deficient (Pafah2(-/-)) mice...
  13. pmc Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors
    Alexander Adibekian
    The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, USA
    Nat Chem Biol 7:469-78. 2011
    ..including peptidases (acyl-peptide hydrolase, or APEH), lipases (platelet-activating factor acetylhydrolase-2, or PAFAH2) and uncharacterized hydrolases (α,β-hydrolase-11, or ABHD11), with exceptional potency in cells (sub-nanomolar) ..