Gene Symbol: PAF1
Description: PAF1 homolog, Paf1/RNA polymerase II complex component
Alias: F23149_1, PD2, RNA polymerase II-associated factor 1 homolog, Paf1, RNA polymerase II associated factor, homolog, pancreatic differentiation protein 2
Species: human
Products:     PAF1

Top Publications

  1. Muntean A, Tan J, Sitwala K, Huang Y, Bronstein J, Connelly J, et al. The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis. Cancer Cell. 2010;17:609-21 pubmed publisher
    ..Deletions of MLL that abolish interactions with PAFc also eliminate MLL-AF9 mediated immortalization indicating an essential function for this interaction in leukemogenesis. ..
  2. Rozenblatt Rosen O, Nagaike T, FRANCIS J, Kaneko S, Glatt K, Hughes C, et al. The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors. Proc Natl Acad Sci U S A. 2009;106:755-60 pubmed publisher
    ..Its product, the Cdc73 protein, is a component of the RNA polymerase II and chromatin-associated human Paf1 complex (Paf1C)...
  3. Kim J, Guermah M, Roeder R. The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS. Cell. 2010;140:491-503 pubmed publisher
    Genetic and cell-based studies have implicated the PAF1 complex (PAF1C) in transcription-associated events, but there has been no evidence showing a direct role in facilitating transcription of a natural chromatin template...
  4. Kim J, Guermah M, McGinty R, Lee J, Tang Z, Milne T, et al. RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell. 2009;137:459-71 pubmed publisher
    ..These studies establish the natural H2B ubiquitylation factors in human cells and also detail the mechanistic basis for H2B ubiquitylation and function during transcription. ..
  5. Moniaux N, Nemos C, Deb S, Zhu B, Dornreiter I, Hollingsworth M, et al. The human RNA polymerase II-associated factor 1 (hPaf1): a new regulator of cell-cycle progression. PLoS ONE. 2009;4:e7077 pubmed publisher
    ..Our results identify hPaf1 and the hPAF complex as key regulators of cell-cycle progression. Mutation or loss of stoichiometry of at least one of the members may potentially lead to cancer development. ..
  6. Sobhian B, Laguette N, Yatim A, Nakamura M, Levy Y, Kiernan R, et al. HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP. Mol Cell. 2010;38:439-51 pubmed publisher
    ..consists of the core active P-TEFb, MLL-fusion partners involved in leukemia (AF9, AFF4, AFF1, ENL, and ELL), and PAF1 complex. Importantly, Tatcom1 formation relies on P-TEFb while optimal CDK9 CTD-kinase activity is AF9 dependent...
  7. Marazzi I, Ho J, Kim J, Manicassamy B, Dewell S, Albrecht R, et al. Suppression of the antiviral response by an influenza histone mimic. Nature. 2012;483:428-33 pubmed publisher
    ..A H3N2 subtype possesses a histone-like sequence (histone mimic) that is used by the virus to target the human PAF1 transcription elongation complex (hPAF1C)...
  8. Yart A, Gstaiger M, Wirbelauer C, Pecnik M, Anastasiou D, Hess D, et al. The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II. Mol Cell Biol. 2005;25:5052-60 pubmed
    ..Here we show that parafibromin physically interacts with human orthologs of yeast Paf1 complex components, including PAF1, LEO1, and CTR9, that are involved in transcription elongation and 3' end ..
  9. Wu J, Xu W. Histone H3R17me2a mark recruits human RNA polymerase-associated factor 1 complex to activate transcription. Proc Natl Acad Sci U S A. 2012;109:5675-80 pubmed publisher
    ..Using an unbiased biochemical approach, we discovered that the transcription elongation-associated PAF1 complex (PAF1c) directly interacts with H3R17me2a...

More Information

Publications116 found, 100 shown here

  1. Zhu B, Mandal S, Pham A, Zheng Y, Erdjument Bromage H, Batra S, et al. The human PAF complex coordinates transcription with events downstream of RNA synthesis. Genes Dev. 2005;19:1668-73 pubmed
    ..Thus, in addition to coordinating events during transcription (initiation, promoter clearance, and elongation), hPAF also coordinates events in RNA quality control. ..
  2. Moniaux N, Nemos C, Schmied B, Chauhan S, Deb S, Morikane K, et al. The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis. Oncogene. 2006;25:3247-57 pubmed
    ..PD2 is the human homologue of the RNA polymerase II-associated factor 1 (hPaf1). In yeast, Paf1 is part of the transcription machinery, acting as a docking protein in between the complexes Rad6-Bre1, COMPASS-..
  3. Pavri R, Zhu B, Li G, Trojer P, Mandal S, Shilatifard A, et al. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell. 2006;125:703-17 pubmed
  4. Rozenblatt Rosen O, Hughes C, Nannepaga S, Shanmugam K, Copeland T, Guszczynski T, et al. The parafibromin tumor suppressor protein is part of a human Paf1 complex. Mol Cell Biol. 2005;25:612-20 pubmed
    ..tumor syndrome 2) tumor suppressor gene, is the human homologue of yeast Cdc73, part of the yeast RNA polymerase II/Paf1 complex known to be important for histone modification and connections to posttranscriptional events...
  5. Pulgar V, Yamaleyeva L, Varagic J, McGee C, Bader M, Dechend R, et al. Functional changes in the uterine artery precede the hypertensive phenotype in a transgenic model of hypertensive pregnancy. Am J Physiol Endocrinol Metab. 2015;309:E811-7 pubmed publisher
    ..134 ± 9 %kmax, p < 0.05, pd2 5.92 ± 0.08 vs. 5.85 ± 0.03, p < 0.05)...
  6. Cohen A, Habib A, Laor D, Yadav S, Kupiec M, Weisman R. TOR complex 2 in fission yeast is required for chromatin-mediated gene silencing and assembly of heterochromatic domains at subtelomeres. J Biol Chem. 2018;293:8138-8150 pubmed publisher partially suppressed by loss of the anti-silencer Epe1 and fully suppressed by loss of the Pol II-associated Paf1 complex, two chromatin regulators that have been implicated in heterochromatin stability and spreading...
  7. Zhang K, Tang Y, Zhang Y, Ojamaa K, Li Y, Saini A, et al. Comparison of therapeutic triiodothyronine versus metoprolol in treatment of myocardial infarction in rats. Thyroid. 2018;: pubmed publisher
    ..1±0.6%, 6.6±0.6% vs. 8.2±0.7%, T3, Met vs. MI, respectively) and aortic vasorelaxation responsiveness (pD2 6.97±0.22, 6.83±0.21 vs. 6.66±0.22, T3, Met vs MI, respectively)...
  8. Bomfim M, Andrade G, Del Collado M, Sangalli J, Fontes P, Nogueira M, et al. Antioxidant responses and deregulation of epigenetic writers and erasers link oxidative stress and DNA methylation in bovine blastocysts. Mol Reprod Dev. 2017;: pubmed publisher
    ..altered expression of the epigenetic-associated transcripts DNMT3A, H2AFZ, H3F3B, HDAC2, MORF4L2, REST, and PAF1. In addition, we demonstrated that embryos cultured under high oxygen partial pressure have increased global DNA ..
  9. Ergul M, Turgut N, Sarac B, Altun A, Yildirim S, Bagcivan I. Investigating the effects of the Rho-kinase enzyme inhibitors AS1892802 and fasudil hydrochloride on the contractions of isolated pregnant rat myometrium. Eur J Obstet Gynecol Reprod Biol. 2016;202:45-50 pubmed publisher
    ..oxide synthase inhibitor) on oxytocin-induced myometrial contractions were measured, and values for -log10EC50 (pD2) and mean maximal inhibition (Emax) were compared...
  10. Lewis R, Feetham C, Gentles L, Penny J, Tregilgas L, Tohami W, et al. Benzamil sensitive ion channels contribute to volume regulation in canine chondrocytes. Br J Pharmacol. 2013;168:1584-96 pubmed publisher
    ..5 nS per cell with high selectivity for Na(+) . Benzamil hyperpolarized chondrocytes by approximately 8 mV with a pD2 8.4. Chondrocyte regulatory volume decrease (RVI) was inhibited by benzamil (pD2 7...
  11. García P, Encinar del Dedo J, Ayté J, Hidalgo E. Genome-wide Screening of Regulators of Catalase Expression: ROLE OF A TRANSCRIPTION COMPLEX AND HISTONE AND tRNA MODIFICATION COMPLEXES ON ADAPTATION TO STRESS. J Biol Chem. 2016;291:790-9 pubmed publisher
    ..Thus, the transcription elongation complex Paf1, the histone methylase Set1-COMPASS, and the translation-related Trm112 dimers are all involved in full expression ..
  12. Yamaleyeva L, Pulgar V, Lindsey S, Yamane L, Varagic J, McGee C, et al. Uterine artery dysfunction in pregnant ACE2 knockout mice is associated with placental hypoxia and reduced umbilical blood flow velocity. Am J Physiol Endocrinol Metab. 2015;309:E84-94 pubmed publisher
    ..Fetal weight and pup-to-placental weight ratio were lower in ACE2 KO vs. WT mice. A higher sensitivity to Ang II [pD2 8.64 ± 0.04 vs. 8.5 ± 0.03 (-log EC50)] and greater maximal contraction to phenylephrine (169.0 ± 9.0 vs...
  13. Kocić I, Szczepańska R, Wapniarska I. Estrogen-induced relaxation of the rat tail artery is attenuated in rats with pulmonary hypertension. Pharmacol Rep. 2010;62:95-9 pubmed
    ..w. ip). The pD2 value (-log EC50) of phenylephrine significantly decreased in the presence of 20 microM of 17beta-estradiol (5...
  14. Jahani Asl A, Cheng C, Zhang C, Bonni A. Pathogenesis of Börjeson-Forssman-Lehmann syndrome: Insights from PHF6 function. Neurobiol Dis. 2016;96:227-235 pubmed publisher
    ..Interestingly, PHF6 physically associates with the PAF1 transcriptional elongation complex and thereby drives neuronal migration in the cerebral cortex...
  15. Domingues P, Golebiowski F, Tatham M, Lopes A, Taggart A, Hay R, et al. Global Reprogramming of Host SUMOylation during Influenza Virus Infection. Cell Rep. 2015;13:1467-1480 pubmed publisher
    ..identified ten virus-induced SUMO targets as potential antiviral factors, including C18orf25 and the SMC5/6 and PAF1 complexes...
  16. Lee Y, Park D, Iyer V. The ATP-dependent chromatin remodeler Chd1 is recruited by transcription elongation factors and maintains H3K4me3/H3K36me3 domains at actively transcribed and spliced genes. Nucleic Acids Res. 2017;45:7180-7190 pubmed publisher
    ..We found that several components of the PAF1 transcription elongation complex contribute to Chd1 recruitment to highly transcribed genes and identified Spt4 as ..
  17. Zacher B, Lidschreiber M, Cramer P, Gagneur J, Tresch A. Annotation of genomics data using bidirectional hidden Markov models unveils variations in Pol II transcription cycle. Mol Syst Biol. 2014;10:768 pubmed publisher
    ..32 new transcribed loci, a regulated initiation-elongation transition, the absence of elongation factors Ctk1 and Paf1 from a class of genes, a distinct transcription mechanism for highly expressed genes and novel DNA sequence motifs ..
  18. Sanz A, Garcia R, Rodriguez Peña J, Nombela C, Arroyo J. Slt2 MAPK association with chromatin is required for transcriptional activation of Rlm1 dependent genes upon cell wall stress. Biochim Biophys Acta Gene Regul Mech. 2018;1861:1029-1039 pubmed publisher
    ..of the complex Slt2-RNA Pol II from the promoters to the coding regions of Rlm1-dependent genes does not rely on Paf1, suggesting a different mechanism from that which is exerted by Slt2 on the Swi4/Swi6 (SBF)-regulated genes.
  19. Kolb E, Gorlick R, Lock R, Carol H, Morton C, Keir S, et al. Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2011;56:595-603 pubmed publisher
    ..The best response was PD2 (progressive disease with growth delay), which was observed in 18 of 32 solid tumor xenografts...
  20. Teppner M, Zell M, Husser C, Ernst B, Pähler A. Quantitative profiling of prostaglandins as oxidative stress biomarkers in vitro and in vivo by negative ion online solid phase extraction - Liquid chromatography-tandem mass spectrometry. Anal Biochem. 2016;498:68-77 pubmed publisher
    ..markers for oxidative stress such as 8-iso-prostaglandin F2α and the prostaglandin isomers PE2 and PD2, this method revealed a significant increase of 15R-prostaglandin D2 from 236.1 ± 138...
  21. Vos S, Farnung L, Boehning M, Wigge C, Lindén A, Urlaub H, et al. Structure of activated transcription complex Pol II-DSIF-PAF-SPT6. Nature. 2018;560:607-612 pubmed publisher
    ..requires the kinase function of the positive transcription elongation factor b (P-TEFb) and the elongation factors PAF1 complex (PAF) and SPT6...
  22. Deliu E, Arecco N, Morandell J, Dotter C, Contreras X, Girardot C, et al. Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental gene expression and cognition. Nat Neurosci. 2018;21:1717-1727 pubmed publisher
    ..that Setd5 regulates RNA polymerase II dynamics and gene transcription via its interaction with the Hdac3 and Paf1 complexes, findings potentially explaining the gene expression defects observed in Setd5-haploinsufficient mice...
  23. Yang H, Howard M, Dean C. Physical coupling of activation and derepression activities to maintain an active transcriptional state at FLC. Proc Natl Acad Sci U S A. 2016;113:9369-74 pubmed publisher
    ..We also find association of SDG8 with the transcription machinery, namely RNA polymerase II and the PAF1 complex. Delivery of the active histone modifications is therefore likely to be through transcription at the locus...
  24. Botigelli R, Razza E, Pioltine E, Fontes P, Schwarz K, Leal C, et al. Supplementing in vitro embryo production media by NPPC and sildenafil affect the cytoplasmic lipid content and gene expression of bovine cumulus-oocyte complexes and embryos. Reprod Biol. 2018;18:66-75 pubmed publisher
    ..During IVM, sildenafil increased the mRNA relative abundance of HSF1 and PAF1 and decreased REST in blastocysts. The use of sildenafil in IVC increased the LC of blastocysts...
  25. Alkozi H, Pintor J. TRPV4 activation triggers the release of melatonin from human non-pigmented ciliary epithelial cells. Exp Eye Res. 2015;136:34-7 pubmed publisher
    ..TRPV4 by GSK1016790A permitted to observe a melatonin increase which was concentration-dependent, and provided a pD2 value of -8.5 ± 0.1 (EC50 of 3.0 nM)...
  26. Mazina M, Derevyanko P, Kocheryzhkina E, Nikolenko Y, Krasnov A, Vorobyeva N. [Coactivator complexes participate in different stages of the Drosophila melanogaster hsp70 gene transcription]. Genetika. 2017;53:155-64 pubmed
    ..We assume that coactivators CHD1, ISWI, Brm, Kismet-L, INO80, Mi-2, Gcn5, Lid/KDM5, Set1, DART1, DART4, SSRP1, PAF1, and Fs(1)h/Brd4 bind to the promoter of the active hsp70 gene and migrate to its coding region together with ..
  27. Shivji M, Renaudin X, Williams C, Venkitaraman A. BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation. Cell Rep. 2018;22:1031-1039 pubmed publisher
    ..BRCA2 inactivation decreases RNAPII-associated factor 1 (PAF1) recruitment (which normally promotes RNAPII release) and diminishes H2B Lys120 ubiquitination, impeding nascent ..
  28. Maham M, Nasrollahzadeh M, Bagherzadeh M, Akbari R. Green Synthesis of Palladium/Titanium Dioxide Nanoparticles and Their Application for the Reduction of Methyl Orange, Congo Red and Rhodamine B in Aqueous Medium. Comb Chem High Throughput Screen. 2017;: pubmed publisher
    ..compounds, as phenolic acids, and stabilizing agents, as flavonols that responsible for the bioreduction of Pd2+ and stabilization of Pd NPs...
  29. Schlodder E, Cetin M, Lendzian F. Temperature dependence of the oxidation kinetics of TyrZ and TyrD in oxygen-evolving photosystem II complexes throughout the range from 320K to 5K. Biochim Biophys Acta. 2015;1847:1283-96 pubmed publisher
    ..The rate is independent of temperature between 5K and 250K. It is concluded that TyrD donates the electron to P680(•+) via PD2.
  30. Strikoudis A, Lazaris C, Trimarchi T, Galvao Neto A, Yang Y, Ntziachristos P, et al. Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a. Nat Cell Biol. 2016;18:1127-1138 pubmed publisher
    ..Mechanistically, we attribute Phf5a function to the stabilization of the Paf1 transcriptional complex and control of RNA polymerase II elongation on pluripotency loci...
  31. Zakari M, Trimble Ross R, Peak A, Blanchette M, Seidel C, Gerton J. The SMC Loader Scc2 Promotes ncRNA Biogenesis and Translational Fidelity. PLoS Genet. 2015;11:e1005308 pubmed publisher
    ..Here we report that Scc2 is important for gene expression in budding yeast. Scc2 and the transcriptional regulator Paf1 collaborate to promote the production of Box H/ACA snoRNAs which guide pseudouridylation of RNAs including ..
  32. Pistorius K, Souza P, De Matteis R, Austin Williams S, Primdahl K, Vik A, et al. PDn-3 DPA Pathway Regulates Human Monocyte Differentiation and Macrophage Function. Cell Chem Biol. 2018;25:749-760.e9 pubmed publisher
    ..This intermediate was enzymatically converted by epoxide hydrolases to PD1n-3 DPA and PD2n-3 DPA, with epoxide hydrolase 2 converting 16S,17S-ePDn-3 DPA to PD2n-3 DPA in ..
  33. Pruchnik H, Lis T, Latocha M, Zielińska A, Pruchnik F. Palladium(II) complexes with tris(2-carboxyethyl)phosphine, structure, reactions and cytostatic activity. J Inorg Biochem. 2016;156:14-21 pubmed publisher
    ..New palladium(II) complexes with (TCEP): trans-[PdCl2(TCEP)2] (1) and trans-[Pd2(μ-Cl)2Cl2(TCEP)2] (2) were fully characterized by (1)H, (13)C, (31)P NMR, IR and ESI-MS spectroscopic techniques...
  34. Lu C, Tian Y, Wang S, Su Y, Mao T, Huang T, et al. Phosphorylation of SPT5 by CDKD;2 Is Required for VIP5 Recruitment and Normal Flowering in Arabidopsis thaliana. Plant Cell. 2017;29:277-291 pubmed publisher
    ..composed of Cyclin-dependent kinase 9 (CDK9) and cyclin T, interacts with the RNA polymerase II-associated factor1 (PAF1) complex. However, the mechanism of SPT5 phosphorylation is not well understood in plants...
  35. Cao Q, Yamamoto J, Isobe T, Tateno S, Murase Y, Chen Y, et al. Characterization of the Human Transcription Elongation Factor Rtf1: Evidence for Nonoverlapping Functions of Rtf1 and the Paf1 Complex. Mol Cell Biol. 2015;35:3459-70 pubmed publisher
    Restores TBP function 1 (Rtf1) is generally considered to be a subunit of the Paf1 complex (PAF1C), a multifunctional protein complex involved in histone modification and transcriptional or posttranscriptional regulation...
  36. Prusty S, Krishnaswamy S, Bandi S, Chandrika B, Luo J, McIndoe J, et al. Reversible Mechanical Interlocking of D-Shaped Molecular Karabiners bearing Coordination-Bond Loaded Gates: Route to Self-Assembled [2]Catenanes. Chemistry. 2015;21:15174-87 pubmed publisher
    ..Pd(II) components, [Pd(L')(NO3 )2 ], in an equimolar ratio yielded binuclear complexes, 1 a-d of [Pd2 (L')2 (L1)2 ](NO3 )4 formulation where L' stands for ethylenediamine (en), tetramethylethylenediamine (tmeda), 2,2'-..
  37. Fonseca B, Martínez Águila A, de Lara M, Pintor J. Diadenosine tetraphosphate as a potential therapeutic nucleotide to treat glaucoma. Purinergic Signal. 2017;13:171-177 pubmed publisher
    ..9 ± 4.0% in the C57BL/6J mice. Concentration response curves in both animal strains produced similar pD2 values; these being 4.9 ± 0.5 and 5.1 ± 0...
  38. Soloviev A, Zholos A, Ivanova I, Novokhatska T, Tishkin S, Raevska A, et al. Plasmonic gold nanoparticles possess the ability to open potassium channels in rat thoracic aorta smooth muscles in a remote control manner. Vascul Pharmacol. 2015;72:190-6 pubmed publisher a concentration-dependent and endothelium-independent manner in SM thoracic aorta, with mean value of pD2 (-log EC50) 4.2±0.03, Emax=55±4%...
  39. Preston D, McNeill S, Lewis J, Giles G, Crowley J. Enhanced kinetic stability of [Pd2L4](4+) cages through ligand substitution. Dalton Trans. 2016;45:8050-60 pubmed publisher
    ..ligands (with amino groups either in the 2-() or 3-() positions of the terminal pyridines) and their respective [Pd2()4](4+) cages...
  40. Bhanja A, Mishra S, Das Saha K, Sinha C. A fluorescence 'turn-on' chemodosimeter for the specific detection of Pd2+ by a rhodamine appended Schiff base and its application in live cell imaging. Dalton Trans. 2017;46:9245-9252 pubmed publisher
    ..The limit of detection (LOD) of Pd(ii) by RD is 50 nM at pH 7.4. Fluorescence microscopic studies help in imaging the cellular uptake of Pd2+ at the nM level in the HCT116 (Human colorectal carcinoma) cell line. ..
  41. Fonseca G, Cohen M, Nichols A, Barrett J, Mymryk J. Viral retasking of hBre1/RNF20 to recruit hPaf1 for transcriptional activation. PLoS Pathog. 2013;9:e1003411 pubmed publisher
  42. De Gois S, Slama P, Pietrancosta N, Erdozain A, Louis F, Bouvrais Veret C, et al. Ctr9, a Protein in the Transcription Complex Paf1, Regulates Dopamine Transporter Activity at the Plasma Membrane. J Biol Chem. 2015;290:17848-62 pubmed publisher
    ..demonstrate that Ctr9 localization is not restricted to the nucleus, as previously described for the transcription complex Paf1. Taken together, our data provide evidence that Ctr9 modulates DAT function by regulating its trafficking.
  43. Derikvand P, Etemadifar Z, Saber H. Sulfur Removal from Dibenzothiophene by Newly Isolated Paenibacillus validus Strain PD2 and Process Optimization in Aqueous and Biphasic (Model-Oil) Systems. Pol J Microbiol. 2015;64:47-54 pubmed
    ..A new strain of Paenibacillus validus (strain PD2) was isolated from oil contaminated soils that is able to desulfurize DBT...
  44. Xie M, Wang Y, Li J, Du C, Zhang Y, Hao E, et al. A straightforward entry to chiral carbocyclic nucleoside analogues via the enantioselective [3+2] cycloaddition of α-nucleobase substituted acrylates. Chem Commun (Camb). 2015;51:12451-4 pubmed publisher
    ..With Pd2(dba)3-L5 as the catalyst, carbocyclic purine, uracil, and thymine nucleoside analogues with quaternary ..
  45. Wu Z, Hunter D, Batchelor T, Dey R. Side-stream tobacco smoke-induced airway hyperresponsiveness in early postnatal period is involved nerve growth factor. Respir Physiol Neurobiol. 2016;223:1-8 pubmed publisher
    ..Exposure to SS significantly altered pulmonary function in PD2, accompanied with an enhanced SP innervation in airway...
  46. Portnoy V, Lin S, Li K, Burlingame A, Hu Z, Li H, et al. saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription. Cell Res. 2016;26:320-35 pubmed publisher
    ..complex, which, in addition to saRNA-Ago2 complex, includes RHA and CTR9, the latter being a component of the PAF1 complex...
  47. El Zaeddi H, Martínez Tomé J, Calín Sánchez A, Burló F, Carbonell Barrachina A. Irrigation dose and plant density affect the volatile composition and sensory quality of dill (Anethum graveolens L.). J Sci Food Agric. 2017;97:427-433 pubmed publisher
    ..56 plants m-2 , considered as a control; PD1 = 4.44 plants m-2 ; and PD2 = 7...
  48. Xu Y, Bernecky C, Lee C, Maier K, Schwalb B, Tegunov D, et al. Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex. Nat Commun. 2017;8:15741 pubmed publisher
    ..Paf1C comprises the five subunits Paf1, Leo1, Ctr9, Cdc73 and Rtf1, and binds to the RNA polymerase II (Pol II) transcription elongation complex (EC)...
  49. Ui A, Nagaura Y, Yasui A. Transcriptional elongation factor ENL phosphorylated by ATM recruits polycomb and switches off transcription for DSB repair. Mol Cell. 2015;58:468-82 pubmed publisher
    ..Our data suggest that ATM-dependent phosphorylation of ENL functions as switch from elongation to Polycomb-mediated repression to preserve genome integrity. ..
  50. Tawa M, Shimosato T, Iwasaki H, Imamura T, Okamura T. Effects of hydrogen peroxide on relaxation through the NO/sGC/cGMP pathway in isolated rat iliac arteries. Free Radic Res. 2015;49:1479-87 pubmed publisher
    ..The relaxant response to BAY 41-2272 (pD2: 6.79 ± 0.10 and 6.62 ± 0.17), BAY 60-2770 (pD2: 9.57 ± 0...
  51. Bandi S, Chand D. Cage-to-Cage Cascade Transformations. Chemistry. 2016;22:10330-5 pubmed publisher
    A series of Pd2 L4 -type binuclear self-assembled coordination cages (1-4), where L stands for a nonchelating bidentate ligand, were prepared...
  52. Janusson E, Zijlstra H, Nguyen P, MacGillivray L, Martelino J, McIndoe J. Real-time analysis of Pd2(dba)3 activation by phosphine ligands. Chem Commun (Camb). 2017;53:854-856 pubmed publisher
    ..This provides insight into the effect of ligand and preparation conditions on activation and allows for establishment of rational activation protocols. ..
  53. Wang Z, Li X, Liang H, Ning J, Zhou Z, Li G. Equilibrium, kinetics and mechanism of Au3+, Pd2+ and Ag+ ions adsorption from aqueous solutions by graphene oxide functionalized persimmon tannin. Mater Sci Eng C Mater Biol Appl. 2017;79:227-236 pubmed publisher
    ..Therefore, the PT-GO bio-adsorbent would be an ideal adsorbent for removal of precious metal ions and broaden the potential applications of persimmon tannin in environmental research. ..
  54. Rodrigues J, Lydall D. Paf1 and Ctr9, core components of the PAF1 complex, maintain low levels of telomeric repeat containing RNA. Nucleic Acids Res. 2017;: pubmed publisher
    The conserved PAF1 complex (Cdc73, Paf1, Ctr9, Leo1 and Rtf1, in yeast), binds RNA pol II, and affects levels of many RNAs. Although PAF1 is a complex, there is evidence that different components perform different functions...
  55. Broegger T, Andersson K, Aalkjaer C, Forman A, Boedtkjer D. Sensitivity to the thromboxane A2 analog U46619 varies with inner diameter in human stem villous arteries. Placenta. 2016;39:111-5 pubmed publisher
    ..Using an isometric wire myograph, the contractility and sensitivity (pD2) to the thromboxane A2 mimetic U46619, PGF2? and ET-1 were investigated in isolated human stem villous arteries and ..
  56. Song Y, Rui Y, Bedane G, Li J. Morphological Characteristics of Maize Canopy Development as Affected by Increased Plant Density. PLoS ONE. 2016;11:e0154084 pubmed publisher
    ..e. 2, 6, 12 and 20 plants m-2 (referred to PD2, PD6, PD12 and PD20 respectively)...
  57. Dahms P, Martin A, Ganz H, Eisen J, Coil D. Draft Genome Sequence of Propionibacterium avidum Strain UCD-PD2 Isolated from a Feline Anal Sac. Genome Announc. 2017;5: pubmed publisher
    ..we present the draft genome sequence of Propionibacterium (Cutibacterium) avidum strain UCD-PD2. The assembly contains 2,667,287 bp in 51 contigs...
  58. Johnstone M, Schwarze E, Ahrens J, Schwarzer D, Holstein J, Dittrich B, et al. Desymmetrization of an Octahedral Coordination Complex Inside a Self-Assembled Exoskeleton. Chemistry. 2016;22:10791-5 pubmed publisher
    ..centrally functionalized, ribbon-shaped [6]polynorbornane ligand L that self-assembles with Pd(II) cations into a {Pd2 L4 } coordination cage is reported...
  59. Bahrampour S, Thor S. Ctr9, a Key Component of the Paf1 Complex, Affects Proliferation and Terminal Differentiation in the Developing Drosophila Nervous System. G3 (Bethesda). 2016;6:3229-3239 pubmed publisher
    The Paf1 protein complex (Paf1C) is increasingly recognized as a highly conserved and broadly utilized regulator of a variety of transcriptional processes...
  60. Chaturvedi D, Inaba M, Scoggin S, Buszczak M. Drosophila CG2469 Encodes a Homolog of Human CTR9 and Is Essential for Development. G3 (Bethesda). 2016;6:3849-3857 pubmed publisher
    Conserved from yeast to humans, the Paf1 complex participates in a number of diverse processes including transcriptional initiation and polyadenylation. This complex typically includes five proteins: Paf1, Rtf1, Cdc73, Leo1, and Ctr9...
  61. Karmakar S, Dey P, Vaz A, Bhaumik S, Ponnusamy M, Batra S. PD2/PAF1 at the Crossroads of the Cancer Network. Cancer Res. 2018;78:313-319 pubmed publisher
    Pancreatic differentiation 2 (PD2)/RNA polymerase II-associated factor 1 (PAF1) is the core subunit of the human PAF1 complex (PAF1C) that regulates the promoter-proximal pausing of RNA polymerase II as well as transcription elongation ..
  62. Colletto C, Burés J, Larrosa I. Reaction monitoring reveals poisoning mechanism of Pd2(dba)3 and guides catalyst selection. Chem Commun (Camb). 2017;53:12890-12893 pubmed publisher
    ..Based on these studies, we report a new catalytic system, employing a dba-free Pd catalyst, which allows for the first time the direct C3 arylation of benzo[b]thiophenes with electron-deficient aryl iodides at room temperature. ..
  63. Raupach E, Martens J, Arndt K. Evidence for Regulation of ECM3 Expression by Methylation of Histone H3 Lysine 4 and Intergenic Transcription in Saccharomyces cerevisiae. G3 (Bethesda). 2016;6:2971-81 pubmed publisher
    ..the effects of various chromatin regulators on the expression of ECM3 These analyses identified roles for the Paf1 complex in positively regulating ECM3 transcription through methylation of histone H3 at lysine 4 (K4) and for Paf1 ..
  64. Antosz W, Pfab A, Ehrnsberger H, Holzinger P, Köllen K, Mortensen S, et al. The Composition of the Arabidopsis RNA Polymerase II Transcript Elongation Complex Reveals the Interplay between Elongation and mRNA Processing Factors. Plant Cell. 2017;29:854-870 pubmed publisher
    ..and mass spectrometry, we demonstrate that in Arabidopsis thaliana, the TEFs SPT4/SPT5, SPT6, FACT, PAF1-C, and TFIIS copurified with each other and with elongating RNAPII, while P-TEFb was not among the interactors...
  65. Gerlach J, Furrer M, Gallant M, Birkel D, Baluapuri A, Wolf E, et al. PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters. Proc Natl Acad Sci U S A. 2017;114:E9224-E9232 pubmed publisher
    ..Here we identify the PAF1 complex, and specifically its component Leo1, as a factor that helps recruit Myc to target genes...
  66. Takahashi A, Tsutsumi R, Kikuchi I, Obuse C, Saito Y, Seidi A, et al. SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver. Mol Cell. 2011;43:45-56 pubmed publisher
    ..Hence, SHP2 governs the opposing functions of parafibromin, deregulation of which may cause the development of tumors or developmental malformations. ..
  67. Wier A, Mayekar M, Heroux A, Arndt K, VanDemark A. Structural basis for Spt5-mediated recruitment of the Paf1 complex to chromatin. Proc Natl Acad Sci U S A. 2013;110:17290-5 pubmed publisher
    ..The structure reveals the basis for recognition of the repeat motif of Spt5, a key player in the recruitment of gene regulatory factors to RNA polymerase II. ..
  68. Mbonye U, Karn J. Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure. Virology. 2014;454-455:328-39 pubmed publisher
    ..An in-depth comprehensive understanding of the molecular control of HIV-1 transcription should inform the development of optimal combinatorial reactivation strategies that are intended to purge the latent viral reservoir...
  69. Seo H, Kwon C, Lee D. The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast. Curr Genet. 2018;64:741-752 pubmed publisher
    ..a distinct pathway that regulates subtelomere silencing and facultative heterochromatin formation through the Paf1 complex subunit, Leo1...
  70. Zhu B, Zheng Y, Pham A, Mandal S, Erdjument Bromage H, Tempst P, et al. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol Cell. 2005;20:601-11 pubmed
    ..In contrast, RNAi against the RNF20/40 complex or hPAF complex reduces H2B monoubiquitination, lowers methylation levels at H3 lysines 4 and 79, and represses HOX gene expression. ..
  71. Nilson K, Price D. The Role of RNA Polymerase II Elongation Control in HIV-1 Gene Expression, Replication, and Latency. Genet Res Int. 2011;2011:726901 pubmed publisher
    ..HIV, the causative agent of AIDS, is a worldwide health concern. It is hoped that knowledge of the mechanisms regulating the expression of the HIV genome will lead to treatments and ultimately a cure. ..
  72. Hetzner K, Garcia Cuellar M, Büttner C, Slany R. The interaction of ENL with PAF1 mitigates polycomb silencing and facilitates murine leukemogenesis. Blood. 2017;: pubmed publisher
    ..Here we demonstrate that ENL overcomes polycomb silencing through recruitment of PAF1 via the conserved YEATS domain that recognizes acetylated histone H3...
  73. Chen F, Woodfin A, Gardini A, Rickels R, Marshall S, Smith E, et al. PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II. Cell. 2015;162:1003-15 pubmed publisher
    ..Here, we identify that Pol-II-associated factor 1 (PAF1) possesses an evolutionarily conserved function in metazoans in the regulation of promoter-proximal pausing...
  74. Osipovich A, Gangula R, Vianna P, Magnuson M. Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation. Development. 2016;143:4595-4607 pubmed divergently transcribed with Gt(ROSA26)Sor, is necessary for mammalian development, and interacts with the PAF1 co-transcriptional complex and other proteins...
  75. Fischl H, Howe F, Furger A, Mellor J. Paf1 Has Distinct Roles in Transcription Elongation and Differential Transcript Fate. Mol Cell. 2017;65:685-698.e8 pubmed publisher
    ..transcripts is coordinated by transcription elongation factors (TEFs) such as polymerase-associated factor 1 (Paf1), but it is not known whether TEFs have gene-specific functions...
  76. Wang Z, Wang Z, Liu Z, Ren Y, Zhou Z. Effects of RNA interference-mediated gene silencing of VEGF on the ultrafiltration failure in a rat model of peritoneal dialysis. Biosci Rep. 2017;37: pubmed publisher
    ..Uremic rats were subcategorized into uremia, PD2, VEGF shRNA-2, vector-2, PD2 + Endostar, PD4, VEGF shRNA-4, Vector-4, and PD4 + Endostar groups...
  77. Fal K, Liu M, Duisembekova A, Refahi Y, Haswell E, Hamant O. Phyllotactic regularity requires the Paf1 complex in Arabidopsis. Development. 2017;144:4428-4436 pubmed publisher
    ..Thus, the regularity of spatial, auxin-dependent, patterning at the meristem requires Paf1c. ..
  78. Kai S, Martí Centelles V, Sakuma Y, Mashiko T, Kojima T, Nagashima U, et al. Quantitative Analysis of Self-Assembly Process of a Pd2L4 Cage Consisting of Rigid Ditopic Ligands. Chemistry. 2017;: pubmed publisher
    ..DFT calculation of the TS (transition state) structures for the two steps indicates that the distortion of the trigonal-bipyramidal Pd(II) center at the TS geometries increases the activation free energy of the two steps...
  79. Tan J, Muntean A, Hess J. PAFc, a key player in MLL-rearranged leukemogenesis. Oncotarget. 2010;1:461-5 pubmed
    ..Here, we discuss the potential molecular role of the PAFc in transcriptional dysregulation of MLL target genes and the interplay between PAFc and MLL-rearranged oncoproteins in leukemogenesis. ..
  80. Chu X, Qin X, Xu H, Li L, Wang Z, Li F, et al. Structural insights into Paf1 complex assembly and histone binding. Nucleic Acids Res. 2013;41:10619-29 pubmed publisher
    The highly conserved Paf1 complex (PAF1C) plays critical roles in RNA polymerase II transcription elongation and in the regulation of histone modifications...
  81. Oliveira D, Kato A, Nakamura K, Ikura T, Okada M, Kobayashi J, et al. Histone chaperone FACT regulates homologous recombination by chromatin remodeling through interaction with RNF20. J Cell Sci. 2014;127:763-72 pubmed publisher
    ..Interestingly, PAF1, which has been implicated in transcription as a mediator of FACT and RNF20 association, was dispensable for DNA-..
  82. Yu M, Yang W, Ni T, Tang Z, Nakadai T, Zhu J, et al. RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II. Science. 2015;350:1383-6 pubmed publisher
    ..We found that Pol II-associated factor 1 (PAF1) is a critical regulator of paused Pol II release, that positive transcription elongation factor b (P-TEFb) ..
  83. Karmakar S, Seshacharyulu P, Lakshmanan I, Vaz A, Chugh S, Sheinin Y, et al. hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells. Oncotarget. 2017;8:14806-14820 pubmed publisher
    ..Here, we evaluated the role of hPaf1/PD2, a core component of RNA Polymerase II-Associated Factor (PAF) complex, in self-renewal of OCSCs through marker and ..
  84. Karn J, Stoltzfus C. Transcriptional and posttranscriptional regulation of HIV-1 gene expression. Cold Spring Harb Perspect Med. 2012;2:a006916 pubmed publisher
    ..In cells that are not fully activated, limiting levels of Tat and Rev act as potent blocks to premature virus production. ..
  85. Zhi X, Giroux Leprieur E, Wislez M, Hu M, Zhang Y, Shi H, et al. Human RNA polymerase II associated factor 1 complex promotes tumorigenesis by activating c-MYC transcription in non-small cell lung cancer. Biochem Biophys Res Commun. 2015;465:685-90 pubmed publisher
    ..These results demonstrated the prognostic value of hPAF1C in early-stage NSCLC and the role of hPAF1C in the transcriptional regulation of c-MYC oncogene during NSCLC tumorigenesis. ..
  86. Shema E, Kim J, Roeder R, Oren M. RNF20 inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression. Mol Cell. 2011;42:477-88 pubmed publisher
    ..RNF20 inhibits the interaction between TFIIS and the PAF1 complex and hinders transcriptional elongation...
  87. Sun H, Kim N, Hwang C, Yoo J. Protein Degradation of RNA Polymerase II-Association Factor 1(PAF1) Is Controlled by CNOT4 and 26S Proteasome. PLoS ONE. 2015;10:e0125599 pubmed publisher
    ..PAFc is an evolutionarily conserved, multi-protein complex comprising PAF1, CDC73, CTR9, LEO1, yRTF1 and, in humans, hSKI8...
  88. Dey P, Ponnusamy M, Deb S, Batra S. Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer. PLoS ONE. 2011;6:e26926 pubmed publisher
    ..However, the interconnected network of molecules involved in regulating such processes remains elusive. hPaf1/PD2, a subunit of the human PAF-complex, involved in the regulation of transcriptional elongation has oncogenic ..
  89. Ferdoush J, Karmakar S, Barman P, Kaja A, Uprety B, Batra S, et al. Ubiquitin-Proteasome System Regulation of an Evolutionarily Conserved RNA Polymerase II-Associated Factor 1 Involved in Pancreatic Oncogenesis. Biochemistry. 2017;56:6083-6086 pubmed publisher
    The evolutionarily conserved RNA polymerase II-associated factor 1 (Paf1) from yeast to humans regulates transcription and associated processes, and thus, malfunctions and/or misregulations of Paf1 are associated with cellular pathologies...
  90. Fonseca G, Cohen M, Mymryk J. Adenovirus E1A recruits the human Paf1 complex to enhance transcriptional elongation. J Virol. 2014;88:5630-7 pubmed publisher
    ..The work also demonstrates that E1A induces gene expression by stimulating transcriptional elongation, in addition to its better-characterized effects on transcriptional initiation...
  91. Wu L, Li L, Zhou B, Qin Z, Dou Y. H2B ubiquitylation promotes RNA Pol II processivity via PAF1 and pTEFb. Mol Cell. 2014;54:920-931 pubmed publisher
    ..More importantly, we show that the MSL, PAF1, and RNF20/40 complexes are recruited and stabilized at active gene promoters by direct binary interactions...
  92. Sun W, Kuang X, Liu Y, Tian L, Yan X, Xu W. Crystal structure of the N-terminal domain of human CDC73 and its implications for the hyperparathyroidism-jaw tumor (HPT-JT) syndrome. Sci Rep. 2017;7:15638 pubmed publisher
    CDC73/Parafibromin is a critical component of the Paf1 complex (PAF1C), which is involved in transcriptional elongation and histone modifications...