Gene Symbol: PACSIN1
Description: protein kinase C and casein kinase substrate in neurons 1
Alias: SDPI, protein kinase C and casein kinase substrate in neurons protein 1, syndapin I, syndapin-1
Species: human
Products:     PACSIN1

Top Publications

  1. Modregger J, Ritter B, Witter B, Paulsson M, Plomann M. All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis. J Cell Sci. 2000;113 Pt 24:4511-21 pubmed
    ..These characteristics of the PACSIN protein family suggest a general function in recruitment of the interacting proteins to sites of endocytosis. ..
  2. Qualmann B, Roos J, DiGregorio P, Kelly R. Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein. Mol Biol Cell. 1999;10:501-13 pubmed
    ..Here we describe a novel 52-kDa protein in rat brain that binds the proline-rich C terminus of dynamin. Syndapin I (synaptic, dynamin-associated protein I) is highly enriched in brain where it exists in a high molecular weight ..
  3. Quan A, Xue J, Wielens J, Smillie K, Anggono V, Parker M, et al. Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation. Proc Natl Acad Sci U S A. 2012;109:3760-5 pubmed publisher
    b>Syndapin I (PACSIN 1) is a synaptically enriched membrane tubulating protein that plays important roles in activity-dependent bulk endocytosis and neuronal morphogenesis...
  4. Wang Q, Navarro M, Peng G, Molinelli E, Goh S, Judson B, et al. Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin. Proc Natl Acad Sci U S A. 2009;106:12700-5 pubmed publisher
    ..The regulated deformation of membranes and promotion of tubule constrictions by Pacsin suggests a more versatile function of these proteins in vesiculation and endocytosis beyond their role as scaffold proteins. ..
  5. Anggono V, Robinson P. Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis. J Neurochem. 2007;102:931-43 pubmed
    ..b>Syndapin I, amphiphysin I, and endophilin I are its major partners implicated in SVE...
  6. Jiang L, Chen S, Beals J, Siddique J, Hamman R, Bullock A, et al. Evaluating Community-Based Translational Interventions Using Historical Controls: Propensity Score vs. Disease Risk Score Approach. Prev Sci. 2019;: pubmed publisher
    ..of the lifestyle intervention implemented by the Special Diabetes Program for Indians Diabetes Prevention (SDPI-DP) demonstration project, a translational lifestyle intervention among American Indian and Alaska Native ..
  7. Insinna C, Lu Q, Teixeira I, Harned A, Semler E, Stauffer J, et al. Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport. Nat Commun. 2019;10:428 pubmed publisher
    ..Here, we demonstrate in human cells and zebrafish that the F-BAR domain containing proteins PACSIN1 and -2 play an essential role in ciliogenesis, similar to their binding partner and membrane reorganizer EHD1...
  8. Gao Y, Jiang J, Yang S, Cao J, Han B, Wang Y, et al. Genome-wide association study of Mycobacterium avium subspecies Paratuberculosis infection in Chinese Holstein. BMC Genomics. 2018;19:972 pubmed publisher
    ..e., within 1 Mb) these SNPs, including IL4, IL5, IL13, IRF1, MyD88, PACSIN1, DEF6, TDP2, ZAP70 and CSF2...
  9. Park C, Kang D, Shin G, Seo J, Kim H, Suh P, et al. Identification of novel phosphatidic acid-binding proteins in the rat brain. Neurosci Lett. 2015;595:108-13 pubmed publisher
    ..A lipid-protein overlay assay confirmed that GDI1, PACSIN1, and DPYSL2 interact with not only with PA but also with other phospholipids...

More Information


  1. Xiao B, Chen L, Ke Y, Hang J, Cao L, Zhang R, et al. Identification of methylation sites and signature genes with prognostic value for luminal breast cancer. BMC Cancer. 2018;18:405 pubmed publisher
    ..We also identified an mRNA signature, comprising eight transcripts, ESCO2, PACSIN1, CDCA2, PIGR, PTN, RGMA, KLK4 and CENPA, which was used to divide samples into low- and high-risk groups...
  2. Goretzki B, Glogowski N, Diehl E, Duchardt Ferner E, Hacker C, Gaudet R, et al. Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP2. Structure. 2018;26:1583-1593.e5 pubmed publisher
    ..We determined the affinities of the TRPV4 N terminus for PACSIN1, 2, and 3 SH3 domains and PIP2 and deduce a hierarchical interaction network where Syndapin/PACSIN ..
  3. Jiang L, Yang J, Huang H, Johnson A, Dill E, Beals J, et al. Derivation and Evaluation of a Risk-Scoring Tool to Predict Participant Attrition in a Lifestyle Intervention Project. Prev Sci. 2016;17:461-71 pubmed publisher
    ..intervention project, we analyzed data from the Special Diabetes Program for Indians Diabetes Prevention Program (SDPI-DP), an evidence-based lifestyle intervention to prevent diabetes in 36 American Indian and Alaska Native ..
  4. Widagdo J, Fang H, Jang S, Anggono V. PACSIN1 regulates the dynamics of AMPA receptor trafficking. Sci Rep. 2016;6:31070 pubmed publisher
    ..pHluorin, tagged to the extracellular domain of the GluA2 subunit of AMPARs, we demonstrate dual roles for PACSIN1 in controlling the internalization and recycling of GluA2 after NMDAR activation...
  5. Jiang L, Huang H, Johnson A, Dill E, Beals J, Manson S, et al. Socioeconomic Disparities in Weight and Behavioral Outcomes Among American Indian and Alaska Native Participants of a Translational Lifestyle Intervention Project. Diabetes Care. 2015;38:2090-9 pubmed publisher
    ..We analyzed data from the Special Diabetes Program for Indians Diabetes Prevention (SDPI-DP) Program, an evidence-based lifestyle intervention to prevent diabetes in 36 AI/AN grantee sites...
  6. Xia C, Chen H, Wu S, Xu W. Etiology of isolated pontine infarctions: a study based on high-resolution MRI and brain small vessel disease scores. BMC Neurol. 2017;17:216 pubmed publisher
    ..Acute ischemic stroke patients, comprising 117 PPI patients and 40 SDPI patients, were enrolled...
  7. Jiang L, Chang J, Beals J, Bullock A, Manson S. Neighborhood characteristics and lifestyle intervention outcomes: Results from the Special Diabetes Program for Indians. Prev Med. 2018;111:216-224 pubmed publisher
    ..Census Tract data were linked with those from the Special Diabetes Program for Indians Diabetes Prevention Program (SDPI-DP), an evidence-based lifestyle intervention implemented in 36 AI/AN grantee sites across the US...
  8. Hou W, Izadi M, Nemitz S, Haag N, Kessels M, Qualmann B. The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin. PLoS Biol. 2015;13:e1002233 pubmed publisher
    ..and furthermore promotes Cobl's previously identified interactions with the membrane-shaping F-BAR protein syndapin I, which accumulated with Cobl at nascent dendritic protrusion sites...
  9. Gopalakrishnan C, Jethi S, Kalsi N, Purohit R. Biophysical Aspect of Huntingtin Protein During polyQ: An In Silico Insight. Cell Biochem Biophys. 2016;74:129-39 pubmed publisher
    ..Recent research indicates protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1) as one of the interacting partners of Htt protein...
  10. Gonzales K, Noonan C, Goins R, Henderson W, Beals J, Manson S, et al. Assessing the Everyday Discrimination Scale among American Indians and Alaska Natives. Psychol Assess. 2016;28:51-8 pubmed publisher
    ..Data derived from the Special Diabetes Program for Indians--Healthy Heart Demonstration Project (SDPI-HH), a large-scale initiative to reduce cardiovascular risk among AI/ANs with Type 2 diabetes...
  11. Caron N, Desmond C, Xia J, Truant R. Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin. Proc Natl Acad Sci U S A. 2013;110:14610-5 pubmed publisher
    ..within huntingtin requires an interacting protein, protein kinase C and casein kinase 2 substrate in neurons 1 (PACSIN1)...
  12. Modregger J, DiProspero N, Charles V, Tagle D, Plomann M. PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains. Hum Mol Genet. 2002;11:2547-58 pubmed
  13. Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, et al. A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis. J Biol Chem. 2004;279:40091-9 pubmed
    ..These observations therefore indicate that FBP17 interacts with dynamin and regulates endocytosis by forming vesicotubular structures. ..
  14. Schneider K, Seemann E, Liebmann L, Ahuja R, Koch D, Westermann M, et al. ProSAP1 and membrane nanodomain-associated syndapin I promote postsynapse formation and function. J Cell Biol. 2014;205:197-215 pubmed publisher
    ..Gene knockout and RNAi in individual neurons reveal that the F-BAR protein syndapin I is a crucial postsynaptic coordinator in formation of excitatory synapses...
  15. Mahadevan V, Khademullah C, Dargaei Z, Chevrier J, Uvarov P, Kwan J, et al. Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition. elife. 2017;6: pubmed publisher
    ..The most abundant KCC2 interactor is a neuronal endocytic regulatory protein termed PACSIN1 (SYNDAPIN1)...
  16. Wasiak S, Quinn C, Ritter B, de Heuvel E, Baranes D, Plomann M, et al. The Ras/Rac guanine nucleotide exchange factor mammalian Son-of-sevenless interacts with PACSIN 1/syndapin I, a regulator of endocytosis and the actin cytoskeleton. J Biol Chem. 2001;276:26622-8 pubmed
    ..Mass spectrometry analysis and immunodepletion studies reveal p50 as PACSIN 1/syndapin I, a Src homology 3 domain-containing protein functioning in endocytosis and regulation of actin dynamics...
  17. Desrochers G, Lussier Price M, Omichinski J, Angers A. Multiple Src Homology 3 Binding to the Ubiquitin Ligase Itch Conserved Proline-Rich Region. Biochemistry. 2015;54:7345-54 pubmed publisher
  18. Qian J, Chen W, Lettau M, Podda G, Zörnig M, Kabelitz D, et al. Regulation of FasL expression: a SH3 domain containing protein family involved in the lysosomal association of FasL. Cell Signal. 2006;18:1327-37 pubmed
    ..Members of this protein family are characterized by a similar domain structure and include FBP17, PACSIN1-3, CD2BP1, CIP4, Rho-GAP C1 and several hypothetical proteins...
  19. Lee A, Liu S, Wang T. Identification of novel human kinases that suppress hepatitis C virus infection. J Viral Hepat. 2014;21:716-26 pubmed publisher
    ..mitogen-activated protein kinase kinase 5 (MAP2K5) and protein kinase C and casein kinase substrate in neurons 1 (PACSIN1), potently suppressed HCV infection...
  20. Esashi E, Bao M, Wang Y, Cao W, Liu Y. PACSIN1 regulates the TLR7/9-mediated type I interferon response in plasmacytoid dendritic cells. Eur J Immunol. 2012;42:573-9 pubmed publisher
    ..Knockdown of PACSIN1 by short hairpin RNA (shRNA) in a human pDC cell line significantly inhibited the type I IFN response of the pDCs ..
  21. Cuajungco M, Grimm C, Oshima K, D hoedt D, Nilius B, Mensenkamp A, et al. PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. J Biol Chem. 2006;281:18753-62 pubmed
    ..Such a functional interaction could be important in cell types that show distribution of both proteins to the same subcellular regions such as renal tubule cells where the proteins are associated with the luminal plasma membrane. ..
  22. Zucconi A, Dente L, Santonico E, Castagnoli L, Cesareni G. Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1. J Mol Biol. 2001;307:1329-39 pubmed
    ..Two different proline-rich regions of the p21-activated protein kinase 1 (Pak1) and WAVE/SCAR2 protein retrieve from the library different proteins containing SH3 or WW domains. ..
  23. Goh S, Wang Q, Byrnes L, Sondermann H. Versatile membrane deformation potential of activated pacsin. PLoS ONE. 2012;7:e51628 pubmed publisher
    ..Taken together, our results suggest a versatile role for pacsin-1 in sculpting cellular membranes that is likely dependent both on protein structure and membrane properties. ..
  24. Bai X, Meng G, Li G, Luo M, Zheng X. Crystallization and preliminary X-ray crystallographic analysis of human PACSIN 1 protein. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:73-5 pubmed publisher
    ..65, b = 87.38, c = 91.76 A, alpha = 90.00, beta = 113.61, gamma = 90.00 degrees . There were two molecules in the asymmetric unit and the solvent content was estimated to be about 70.47%. ..
  25. Richnau N, Aspenstrom P. Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1. J Biol Chem. 2001;276:35060-70 pubmed
  26. Gao Y, Yan X, Song A, Chang Y, Gao X, Jiang N, et al. Structural insights into the specific binding of huntingtin proline-rich region with the SH3 and WW domains. Structure. 2006;14:1755-65 pubmed
    ..This study provides structural insights into the specific interactions between Htt PRR and its binding partners as well as the alteration of these interactions that involve PRR, which may have implications for the understanding of HD. ..
  27. Sumoy L, Pluvinet R, Andreu N, Estivill X, Escarceller M. PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family. Gene. 2001;262:199-205 pubmed
    ..Two murine Pacsin genes have been reported to date: Pacsin 1 (equivalent to rat Syndapin I), and Pacsin 2 (like rat Syndapin II and chicken focal adhesion protein FAP52)...