PACRG

Summary

Gene Symbol: PACRG
Description: PARK2 co-regulated
Alias: GLUP, HAK005771, PARK2CRG, RP3-495O10.2, molecular chaperone/chaperonin-binding protein, parkin co-regulated gene protein, parkin coregulated gene protein
Species: human

Top Publications

  1. ncbi Molecular cloning and differential expression patterns of avian glutamate receptor mRNAs
    H P Ottiger
    Institut für Hirnforschung, Universitat Zurich, Switzerland
    J Neurochem 64:2413-26. 1995
  2. ncbi Basal body and flagellum mutants reveal a rotational constraint of the central pair microtubules in the axonemes of trypanosomes
    Catarina Gadelha
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    J Cell Sci 119:2405-13. 2006
  3. ncbi Genomic profiling identifies discrete deletions associated with translocations in glioblastoma multiforme
    Paul J Mulholland
    Human Cytogenetics Laboratory, Cancer Research, UK
    Cell Cycle 5:783-91. 2006
  4. pmc PPARγ-mediated increase in glucose availability sustains chronic Brucella abortus infection in alternatively activated macrophages
    Mariana N Xavier
    Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, CA 95616, USA
    Cell Host Microbe 14:159-70. 2013
  5. ncbi Genetic dissection of immunity in leprosy
    Alexandre Alcais
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Université de Paris René Descartes, Institut National de la Santé et de la Recherche Medicale U 550, Faculte de Medecine Necker, Paris, France, European Union
    Curr Opin Immunol 17:44-8. 2005
  6. doi Linkage disequilibrium pattern and age-at-diagnosis are critical for replicating genetic associations across ethnic groups in leprosy
    Andrea Alter
    McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
    Hum Genet 132:107-16. 2013
  7. doi Parkin co-regulated gene is involved in aggresome formation and autophagy in response to proteasomal impairment
    Juliet M Taylor
    Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Victoria, Australia
    Exp Cell Res 318:2059-70. 2012
  8. doi PARK2 and PACRG are commonly downregulated in clear-cell renal cell carcinoma and are associated with aggressive disease and poor clinical outcome
    Marieta I Toma
    Institute of Pathology, University Hospital Carl Gustav Carus Tehnical University of Dresden, Germany
    Genes Chromosomes Cancer 52:265-73. 2013
  9. pmc Ciliary and non-ciliary expression and function of PACRG during vertebrate development
    Thomas Thumberger
    Institute of Zoology, Working group Embryology, University of Hohenheim, Garbenstraße 30, Stuttgart, 70593, Germany
    Cilia 1:13. 2012
  10. doi Role of rhomboid proteases in bacteria
    Philip Rather
    Department of Microbiology and Immunology, 3001 Rollins Research Bldg, Emory University School of Medicine, Atlanta, GA 30322, USA Atlanta VA Medical Center, Decatur, GA, USA Electronic address
    Biochim Biophys Acta 1828:2849-54. 2013

Research Grants

  1. GENETIC DISSECTION OF MYCOBACTERIAL INFECTION
    Erwin Schurr; Fiscal Year: 2005

Scientific Experts

  • Marieta I Toma
  • Erwin Schurr
  • Martin Blum
  • Philip N Rather
  • Andrea Zoia
  • A Bakija-Konsuo
  • Georgios Psakis
  • Takashi Ikeda
  • Karl Ferdinand Lechtreck
  • Zhibing Zhang
  • Koichi Ichimura
  • N Peekhaus
  • Lili R Mesak
  • D Yin
  • Paul J Lockhart
  • Juliet M Taylor
  • Gabrielle R Wilson
  • Alexandre Alcais
  • Martin B Delatycki
  • Andrea Alter
  • Laurent Abel
  • Kate M Brody
  • Marcelo T Mira
  • Matthew J Farrer
  • Diego Lorenzetti
  • Rupali Chopra
  • Mariana N Xavier
  • Sergey I Nikolaev
  • Thomas Thumberger
  • Yuzuru Imai
  • Christina Gavino
  • Marianna Orlova
  • Kiran Katoch
  • Narinder Mehra
  • Meenakshi Singh
  • Moira K O'Bryan
  • Ruben K Dagda
  • D R Velez
  • Petra Gromova
  • Andreas Koch
  • Vu Hong Thai
  • Nguyen Thu Huong
  • Nguyen Ngoc Ba
  • Sharif Arar
  • Nguyen Van Thuc
  • Kazuho Ikeda
  • Suzanne Lesage
  • Hua Qin Wang
  • Xabier Agirre
  • Dheeraj Malhotra
  • Paul J Mulholland
  • S Ali
  • Catarina Gadelha
  • Keith Gull
  • Ngoc Ba Nguyen
  • Van Thuc Nguyen
  • Hong Thai Vu
  • Hao Deng
  • Jason D Dapper
  • Helen R Dawe
  • Ryosuke Takahashi
  • Monica J Justice
  • Ellen Buschman
  • Andrei Verner
  • Thomas J Hudson
  • Andrew B West
  • Joris A Veltman
  • Renato L Santos
  • Anne Vannier
  • Maria G Winter
  • Kim Nguyen
  • Shafat Ali
  • A Marijke Keestra
  • Shweta Aggarwal
  • Denise M Monack
  • Federico Santoni
  • Amit K Srivastava
  • Vidya L Atluri
  • Paul A Luciw
  • Alexander Hoischen
  • Renee M Tsolis
  • Richard A Eigenheer
  • Vinícius Medeiros Fava
  • Andreas B den Hartigh
  • Alanna M Spees
  • Emanuela Giarin
  • Siddharth Manvati
  • Sambit N Bhattacharya
  • Tobias Kerrinnes
  • Jürgen Groet

Detail Information

Publications58

  1. ncbi Molecular cloning and differential expression patterns of avian glutamate receptor mRNAs
    H P Ottiger
    Institut für Hirnforschung, Universitat Zurich, Switzerland
    J Neurochem 64:2413-26. 1995
    ..One of them, GluP-II, encodes a full-length AMPA-sensitive glutamate receptor GluR2 (GluR-B) homologue, whereas the other two partial ..
  2. ncbi Basal body and flagellum mutants reveal a rotational constraint of the central pair microtubules in the axonemes of trypanosomes
    Catarina Gadelha
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    J Cell Sci 119:2405-13. 2006
    ..in particular flagellar and basal body proteins [gamma-tubulin, delta-tubulin, Parkin co-regulated gene product (PACRG) or the paraflagellar rod protein PFR2] allowed a dissection of the mechanisms for central pair constraint...
  3. ncbi Genomic profiling identifies discrete deletions associated with translocations in glioblastoma multiforme
    Paul J Mulholland
    Human Cytogenetics Laboratory, Cancer Research, UK
    Cell Cycle 5:783-91. 2006
    ..6 and further characterized three regions of copy number change associated with translocations including a discrete deletion involving IGF2R, PARK2, PACRG and QKI and an unbalanced translocation involving POLH, GTPBP2 and PTPRZ1.
  4. pmc PPARγ-mediated increase in glucose availability sustains chronic Brucella abortus infection in alternatively activated macrophages
    Mariana N Xavier
    Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, CA 95616, USA
    Cell Host Microbe 14:159-70. 2013
    ..abortus in AAMs, and for chronic infection, as inactivation of the bacterial glucose transporter gluP reduced both intracellular survival in AAMs and persistence in mice...
  5. ncbi Genetic dissection of immunity in leprosy
    Alexandre Alcais
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Université de Paris René Descartes, Institut National de la Santé et de la Recherche Medicale U 550, Faculte de Medecine Necker, Paris, France, European Union
    Curr Opin Immunol 17:44-8. 2005
    ..leprae. With respect to genome-wide screens, a major breakthrough has been reported this year; variants in the regulatory region shared by PARK2 and PACRG have been identified as being common risk factors for leprosy.
  6. doi Linkage disequilibrium pattern and age-at-diagnosis are critical for replicating genetic associations across ethnic groups in leprosy
    Andrea Alter
    McGill Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
    Hum Genet 132:107-16. 2013
    ..Here, we conducted high-density association mapping of PARK2/PACRG SNPs with leprosy and identified 69 SNPs significantly associated with leprosy in 198 single-case Vietnamese ..
  7. doi Parkin co-regulated gene is involved in aggresome formation and autophagy in response to proteasomal impairment
    Juliet M Taylor
    Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Victoria, Australia
    Exp Cell Res 318:2059-70. 2012
    ..The encoded protein (PACRG) is found in Lewy bodies and glial cytoplasmic inclusions, the pathological hallmarks of parkinsonian disorders...
  8. doi PARK2 and PACRG are commonly downregulated in clear-cell renal cell carcinoma and are associated with aggressive disease and poor clinical outcome
    Marieta I Toma
    Institute of Pathology, University Hospital Carl Gustav Carus Tehnical University of Dresden, Germany
    Genes Chromosomes Cancer 52:265-73. 2013
    ..The gene PARK2 and its potentially co-regulated gene PACRG have been previously found to be deleted in clear-cell renal cell carcinomas (ccRCCs)...
  9. pmc Ciliary and non-ciliary expression and function of PACRG during vertebrate development
    Thomas Thumberger
    Institute of Zoology, Working group Embryology, University of Hohenheim, Garbenstraße 30, Stuttgart, 70593, Germany
    Cilia 1:13. 2012
    ..abstract:..
  10. doi Role of rhomboid proteases in bacteria
    Philip Rather
    Department of Microbiology and Immunology, 3001 Rollins Research Bldg, Emory University School of Medicine, Atlanta, GA 30322, USA Atlanta VA Medical Center, Decatur, GA, USA Electronic address
    Biochim Biophys Acta 1828:2849-54. 2013
    ..has shown that loss of the GlpG rhomboid in Escherichia coli alters cefotaxime resistance, loss of the YqgP (GluP) rhomboid in Bacillus subtilis alters cell division and glucose uptake, and loss of the MSMEG_5036 and MSMEG_4904 ..
  11. pmc Mapping of PARK2 and PACRG overlapping regulatory region reveals LD structure and functional variants in association with leprosy in unrelated indian population groups
    Rupali Chopra
    Shri Mata Vaishno Devi University, School of Biotechnology, Katra, Jammu and Kashmir, India
    PLoS Genet 9:e1003578. 2013
    ..Mapping of the PARK2 and PACRG gene regulatory region with 96 SNPs, with a resolution of 1 SNP per 1 Kb for PARK2 gene regulatory region in a ..
  12. doi Exome sequencing identifies putative drivers of progression of transient myeloproliferative disorder to AMKL in infants with Down syndrome
    Sergey I Nikolaev
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
    Blood 122:554-61. 2013
    ..other than GATA1, in genes proven as transformation drivers in non-DS leukemia (EZH2, APC, FLT3, JAK1, PARK2-PACRG, EXT1, DLEC1, and SMC3)...
  13. doi Proteasomal inhibition reduces parkin mRNA in PC12 and SH-SY5Y cells
    Andreas Koch
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr 15, 81377 Munich, Germany
    Parkinsonism Relat Disord 15:220-5. 2009
    ..Since the mRNA of the parkin-coregulated gene PACRG paralleled the parkin mRNA at least partly, we suspect a promoter-driven mechanism...
  14. doi High-resolution genomic copy number profiling of glioblastoma multiforme by single nucleotide polymorphism DNA microarray
    Dong Yin
    Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, Davis Building 5022 Room, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Mol Cancer Res 7:665-77. 2009
    ..The minimum common deleted region included PARK2, PACRG, QKI, and PDE10A genes...
  15. pmc HA-tagging of putative flagellar proteins in Chlamydomonas reinhardtii identifies a novel protein of intraflagellar transport complex B
    Karl Ferdinand Lechtreck
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Cell Motil Cytoskeleton 66:469-82. 2009
    ..The genes encoding nine of these not previously characterized plus the previously described PACRG protein were cloned, inserted into a vector adding a triple-HA tag to the C-terminus of the gene product, and ..
  16. doi Molecular analysis of the PArkin co-regulated gene and association with male infertility
    Gabrielle R Wilson
    Bruce Lefroy Centre for Genetic Health Research, Murdoch Children s Research Institute, Melbourne, 3052, Victoria, Australia
    Fertil Steril 93:2262-8. 2010
    To investigate the potential role of PArkin co-regulated gene (PACRG) in human male infertility.
  17. doi Analysis of PArkin Co-Regulated Gene in a Taiwanese-ethnic Chinese cohort with early-onset Parkinson's disease
    Juliet M Taylor
    Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Victoria, Australia
    Parkinsonism Relat Disord 15:417-21. 2009
    PArkin Co-Regulated Gene (PACRG) is a novel gene which is transcriptionally co-regulated with the parkin gene (PRKN) by a shared bi-directional promoter...
  18. doi AcrB et al.: Obstinate contaminants in a picogram scale. One more bottleneck in the membrane protein structure pipeline
    Georgios Psakis
    Department of Chemistry, Philipps University Marburg, Hans Meerwein Strasse, 35033 Marburg, Germany
    J Struct Biol 166:107-11. 2009
    ..Two of these targets, the Na+ dependent D-glucose/D-galactose transporter (GluP-HP1174) and the carbon starvation protein A (CstA-HP1168), produced small crystals(<40 lm)...
  19. pmc Loss of heterozygosity and copy number abnormality in clear cell renal cell carcinoma discovered by high-density affymetrix 10K single nucleotide polymorphism mapping array
    Marieta I Toma
    Institute for Pathology, University of Technology Dresden, D 01307 Dresden, Germany
    Neoplasia 10:634-42. 2008
    ..As assessed by quantitative polymerase chain reaction, PARK2 and PACRG were down-regulated in 57% and 100%, respectively, and CSF1R was up-regulated in 69% of the cc-RCC cases (..
  20. doi Kit K641E oncogene up-regulates Sprouty homolog 4 and trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumours
    Petra Gromova
    Laboratory of Neurophysiology, Faculty of Medicine, Universite Libre de Bruxelles ULB, Brussels, Belgium
    J Cell Mol Med 13:1536-48. 2009
    ..Gja1/Cx43, Gpc6, Gpr133, Pacrg, Pde3a, Prkar2b, Prkcq/Pkce, Rasd2, Spry4 and Tpbg/5T4 were found to be up-regulated...
  21. doi Expression and localization of the Parkin co-regulated gene in mouse CNS suggests a role in ependymal cilia function
    Gabrielle R Wilson
    Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
    Neurosci Lett 460:97-101. 2009
    Parkin Co-Regulated Gene (PACRG) is a gene that shares a bi-directional promoter with the Parkinson's disease associated gene parkin...
  22. doi A new approach to pleural effusion in cats: markers for distinguishing transudates from exudates
    Andrea Zoia
    UCD School of Agriculture, Food Science and Veterinary Medicine, Dublin 4, Ireland
    J Feline Med Surg 11:847-55. 2009
    ..minus PE cholesterol concentration (CHOLg)), PE total nucleated cells count (TNCCp) and pleural fluid glucose (GLUp)...
  23. pmc MEIG1 is essential for spermiogenesis in mice
    Zhibing Zhang
    Departments of Obstetrics and Gynecology and Biochemistry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 106:17055-60. 2009
    ..We also found that MEIG1 associates with the Parkin co-regulated gene (PACRG) protein, and that testicular PACRG protein is reduced in MEIG1-deficient mice...
  24. pmc Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis
    Ruben K Dagda
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Bioenerg Biomembr 41:473-9. 2009
    ..We propose that PINK1, Omi/HtrA2 and parkin participate at different levels in mitochondrial quality control, converging through some overlapping and some distinct steps to maintain a common phenotype of healthy mitochondrial networks...
  25. doi Deletion of the Parkin co-regulated gene causes defects in ependymal ciliary motility and hydrocephalus in the quakingviable mutant mouse
    Gabrielle R Wilson
    Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Parkville 3052, Australia
    Hum Mol Genet 19:1593-602. 2010
    ..The deletion affects the expression of three genes; quaking (Qk), Parkin-coregulated gene (Pacrg) and parkin (Park2)...
  26. doi Patched1 haploinsufficiency impairs ependymal cilia function of the quaking viable mice, leading to fatal hydrocephalus
    Christina Gavino
    Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec H3T1E2, Canada
    Mol Cell Neurosci 47:100-7. 2011
    The quaking viable (qk(v)) mice harbor an autosomal recessive mutation that deletes the parkin co-regulated gene (pacrg) and parkin (park2) genes, and alters the expression of the quaking (qkI) gene...
  27. doi Leprosy epidemics during history increased protective allele frequency of PARK2/PACRG genes in the population of the Mljet Island, Croatia
    A Bakija-Konsuo
    Clinic for Dermatovenerology Cutis, Vukovarska 22, Dubrovnik, Croatia
    Eur J Med Genet 54:e548-52. 2011
    Two regulatory polymorphisms (rs1040079 and rs9356058) shared by PARK2 and PACRG genes were identified as major risk variants for leprosy susceptibility...
  28. ncbi The neurological mutant quaking(viable) is Parkin deficient
    Diego Lorenzetti
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Room S413, Houston, Texas 77030, USA
    Mamm Genome 15:210-7. 2004
    ..We determined that the mouse Parkin gene, as well as the Parkin co-regulated gene ( Pacrg), lies within the qk(v) deletion...
  29. pmc Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians
    D R Velez
    Dr John T Macdonald Foundation Department of Human Genetics and Miami Institute of Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Int J Tuberc Lung Dis 13:1068-76. 2009
    ..Host defense factors may influence the development of active tuberculosis (TB)...
  30. doi Parkin-co-regulated gene (PACRG) product interacts with tubulin and microtubules
    Takashi Ikeda
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    FEBS Lett 582:1413-8. 2008
    Parkin-co-regulated gene (PACRG) is a gene that shares a bidirectional promoter with Parkinson's disease-related Parkin/Park2 gene. Recently, the PACRG gene product was implicated in the function of flagella...
  31. doi A polysaccharide of Alloiococcus otitidis, a new pathogen of otitis media: chemical structure and synthesis of a neoglycoconjugate thereof
    Sharif Arar
    Department of Chemistry, University of Guelph, Guelph, ON, Canada N1G 2W1
    Carbohydr Res 343:1079-90. 2008
    ..of which the majority was amidically decorated with L-glutamic acid (Glu): {-->6)-beta-GalpNAc-(1-->4)-[Glup-->6]-beta-GlcpA-(1-->3)-beta-GlcpNAc-(1}n. Monomeric analysis performed on other A...
  32. doi Regional and cellular localisation of Parkin co-regulated gene in developing and adult mouse brain
    Kate M Brody
    Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Melbourne, Victoria, 3052, Australia
    Brain Res 1201:177-86. 2008
    Parkin Co-Regulated Gene (PACRG) is a novel gene that is oriented in a head-to-head array with parkin, and expression of the two genes is regulated by a shared bi-directional promoter...
  33. pmc Small regions of overlapping deletions on 6q26 in human astrocytic tumours identified using chromosome 6 tile path array-CGH
    K Ichimura
    Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Oncogene 25:1261-71. 2006
    ..One was 1,002 kb in size and contained PACRG and QKI, while the second was 199 kb and harbours a single gene, ARID1B...
  34. ncbi Defining the breakpoints of the quaking(viable) mouse mutation reveals a duplication from a Parkin intron
    Jason D Dapper
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Mov Disord 20:1369-74. 2005
    ..The mutation has recently been shown to affect three genes in the region: Quaking (qk), Parkin-coregulated gene (Pacrg), and Parkin...
  35. ncbi Genetic analysis of parkin co-regulated gene (PACRG) in patients with early-onset parkinsonism
    Hao Deng
    Department of Neurology, Baylor College of Medicine, 6501 Fannin Street, Houston, TX 77030, USA
    Neurosci Lett 382:297-9. 2005
    Parkin co-regulated gene (PACRG) is a recently identified gene which is transcriptionally co-regulated with parkin gene (PRKN) by a shared bidirectional promoter...
  36. ncbi Linkage of leprosy susceptibility to Parkinson's disease genes
    Ellen Buschman
    McGill Center for the Study of Host Resistance, Montreal, Canada
    Int J Lepr Other Mycobact Dis 72:169-70. 2004
    ..to the 5' regulatory promoter region shared by both the Parkinson's disease gene PARK2 and its co-regulated gene PACRG. The surprising discovery has important implications for the understanding of leprosy pathogenesis and for the ..
  37. pmc Deletion of the Parkin coregulated gene causes male sterility in the quaking(viable) mouse mutant
    Diego Lorenzetti
    Graduate Program in Molecular and Human Genetics, Graduate School of Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:8402-7. 2004
    ..Here, we demonstrate that the deletion of Pacrg is the cause of male sterility in the qk(v) mutant...
  38. pmc Expression of a novel gene, gluP, is essential for normal Bacillus subtilis cell division and contributes to glucose export
    Lili R Mesak
    Department of Microbiology, Institute for Microbiology, Biochemistry and Genetics University of Erlangen Nuremberg, Staudstrasse 5, 91058 Erlangen, Germany
    BMC Microbiol 4:13. 2004
    The Bacillus subtilis glucokinase operon was predicted to be comprised of the genes, yqgP (now named gluP), yqgQ, and glcK. We have previously established a role for glcK in glucose metabolism...
  39. ncbi It's a double knock-out! The quaking mouse is a spontaneous deletion of parkin and parkin co-regulated gene (PACRG)
    Paul J Lockhart
    Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA
    Mov Disord 19:101-4. 2004
    ..entire promoter and first five coding exons of PRKN In addition, the recently described Parkin Co-Regulated Gene (PACRG) is completely deleted. Homozygous Quaking mice show a complete loss of PRKN and PACRG mRNA and protein...
  40. ncbi Susceptibility to leprosy is associated with PARK2 and PACRG
    Marcelo T Mira
    McGill Centre for the Study of Host Resistance and Department of Human Genetics, McGill University, 1650 Cedar Avenue, Montreal, PQ H3G1A4, Canada
    Nature 427:636-40. 2004
    ..overlapping the 5' regulatory region shared by the Parkinson's disease gene PARK2 and the co-regulated gene PACRG. Possession of as few as two of the 17 risk alleles was highly predictive of leprosy...
  41. ncbi A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death
    Yuzuru Imai
    Laboratory for Motor System Neurodegeneration, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    J Biol Chem 278:51901-10. 2003
    ..The gene product, termed Glup/PACRG, forms a large molecular chaperone complex containing heat shock proteins 70 and 90 and chaperonin components...
  42. ncbi Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population
    Marcelo T Mira
    McGill Centre for the Study of Host Resistance and Department of Human Genetics, McGill University, 1650 Cedar Avenue, Montreal, H3G 1A4 PQ, Canada
    Nat Genet 33:412-5. 2003
    ..Of seven microsatellite markers underlying the linkage peak, alleles of two markers (D6S1035 and D6S305) showed strong evidence for association with leprosy (P = 6.7 x 10(-4) and P = 5.9 x 10(-5), respectively)...
  43. ncbi Identification of a novel gene linked to parkin via a bi-directional promoter
    Andrew B West
    Program for Molecular Neuroscience, Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    J Mol Biol 326:11-9. 2003
    ..6 Mb, antisense to parkin. We have tentatively named this novel gene Parkin co-regulated gene, or PACRG. A 35 bp site of bi-directional transcription activation within the common promoter was mapped using dual-..
  44. ncbi The Parkin co-regulated gene product, PACRG, is an evolutionarily conserved axonemal protein that functions in outer-doublet microtubule morphogenesis
    Helen R Dawe
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    J Cell Sci 118:5421-30. 2005
    ..We identified the Parkin co-regulated gene, or PACRG, from such a screen. Male mice deficient in PACRG are sterile, but its function has been little explored...
  45. ncbi Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia
    Xabier Agirre
    Foundation for Applied Medical Research, Division of Cancer, Area of Cell Therapy and Hematology Service, Clinica Universitaria, Universidad de Navarra, Pamplona, Spain
    Int J Cancer 118:1945-53. 2006
    ..PARK2 is linked to a novel described PACRG gene by a bidirectional promoter containing a defined CpG island in its common promoter region...
  46. doi Leprosy as a genetic model for susceptibility to common infectious diseases
    Andrea Alter
    McGill Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, 1650 Cedar Avenue, Montreal, H3G 1A4, QC, Canada
    Hum Genet 123:227-35. 2008
    ..scan in multi-case families from Vietnam led to the positional cloning of global genetic risk factors in the PARK2/PACRG and LTA genes...
  47. ncbi Axonemal localization of Chlamydomonas PACRG, a homologue of the human Parkin-coregulated gene product
    Kazuho Ikeda
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Cell Motil Cytoskeleton 64:814-21. 2007
    A homologue of mammalian PACRG was identified in Sarkosyl-extracted Chlamydomonas axonemes as a protein that may interact with Rib72 (a component of the protofilament ribbon within the outer doublet microtubules)...
  48. ncbi Parkin Co-Regulated Gene (PACRG) is regulated by the ubiquitin-proteasomal system and is present in the pathological features of Parkinsonian diseases
    Juliet M Taylor
    Bruce Lefroy Centre for Genetic Health Research, Murdoch Children s Research Institute, Melbourne, Victoria 3052, Australia
    Neurobiol Dis 27:238-47. 2007
    ..Parkin Co-Regulated Gene (PACRG) is a novel gene that was discovered because of its close genetic proximity to parkin and the two genes were ..
  49. ncbi Cell type-specific upregulation of Parkin in response to ER stress
    Hua Qin Wang
    Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Antioxid Redox Signal 9:533-42. 2007
    ..In parallel with these studies, similar upregulation of the parkin coregulated gene (PACRG)/gene adjacent to parkin (Glup) was also observed by ER stress...
  50. ncbi Mycobacterial infections: PARK2 and PACRG associations in leprosy
    E Schurr
    Montreal General Hospital Research Institute, McGill Center for the Study of Host Resistance, Montreal, PQ, Canada
    Tissue Antigens 69:231-3. 2007
    ..An overview of investigations indicating an important role of host genetics, both major histocompatibility complex (MHC) and non-MHC, in leprosy...
  51. ncbi Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy
    Alexandre Alcais
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Institut National de la Sante et de la Recherche Medicale, U550, 75015 Paris, France
    Nat Genet 39:517-22. 2007
    Host genetics has an important role in leprosy, and variants in the shared promoter region of PARK2 and PACRG were the first major susceptibility factors identified by positional cloning...
  52. ncbi Deletion of the parkin and PACRG gene promoter in early-onset parkinsonism
    Suzanne Lesage
    INSERM U679, Neurology and Experimental Therapeutics, Centre Hospitalier Universitaire CHU Pitié Salpêtrière, Assistance Publique Hopitaux de Paris AP HP, Paris, France
    Hum Mutat 28:27-32. 2007
    ..1-?_7+?del mutation. The promoter region is shared by parkin and the neighboring parkin coregulated gene (PACRG), which are oriented head-to-head and are transcribed on opposite DNA strands...
  53. ncbi Genetic predisposition to leprosy: A major gene reveals novel pathways of immunity to Mycobacterium leprae
    Erwin Schurr
    McGill Centre for the Study of Host Resistance, Department of Human Genetics and Medicine, McGill University, Montreal, PQ, Canada
    Semin Immunol 18:404-10. 2006
    ..We identified genetic variants in the shared promoter region of the PARK2 and PACRG genes as major risk factors of leprosy susceptibility...
  54. pmc PARK2/PACRG polymorphisms and susceptibility to typhoid and paratyphoid fever
    S Ali
    Department of Infectious Diseases, Leiden University Medical Centre, The Netherlands
    Clin Exp Immunol 144:425-31. 2006
    ..Recently polymorphisms in PARK2/PACRG, a gene cluster linked to ubiquitination and proteasome-mediated protein degradation, were found to be associated ..
  55. ncbi Association study of major risk single nucleotide polymorphisms in the common regulatory region of PARK2 and PACRG genes with leprosy in an Indian population
    Dheeraj Malhotra
    National Centre of Applied Human Genetics, School of Life Sciences, Jawaharlal Nehru University, Lok Nayak Jai Prakash Hospital, New Delhi 110067, India
    Eur J Hum Genet 14:438-42. 2006
    Single nucleotide polymorphisms (SNPs) in the regulatory region shared by PARK2 and PACRG have been identified as major risk factors for leprosy susceptibility in two ethnically distinct populations...
  56. ncbi The gluEMP operon from Zymomonas mobilis encodes a high-affinity glutamate carrier with similarity to binding-protein-dependent transport systems
    N Peekhaus
    Institut für Biotechnologie I, Forschungszentrum Julich GmbH, Germany
    Arch Microbiol 165:325-32. 1996
    ..Three clustered genes (gluE, gluM, and gluP) close to ghe grp gene, but on the opposite strand, were identified...

Research Grants5

  1. GENETIC DISSECTION OF MYCOBACTERIAL INFECTION
    Erwin Schurr; Fiscal Year: 2005
    ..tuberculosis through an exposed population. ..