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Genomes and Genes | PACRGSummaryGene Symbol: PACRG Description: PARK2 co-regulated Alias: GLUP, HAK005771, PARK2CRG, RP3-495O10.2, molecular chaperone/chaperonin-binding protein, parkin co-regulated gene protein, parkin coregulated gene protein Species: human Top Publications
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Leprosy epidemics during history increased protective allele frequency of PARK2/PACRG genes in the population of the Mljet Island, CroatiaA Bakija-Konsuo
Clinic for Dermatovenerology Cutis, Vukovarska 22, Dubrovnik, Croatia
Eur J Med Genet 54:e548-52. 2011Two regulatory polymorphisms (rs1040079 and rs9356058) shared by PARK2 and PACRG genes were identified as major risk variants for leprosy susceptibility...- Analysis of PArkin Co-Regulated Gene in a Taiwanese-ethnic Chinese cohort with early-onset Parkinson's diseaseJuliet M Taylor
Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Victoria, Australia
Parkinsonism Relat Disord 15:417-21. 2009PArkin Co-Regulated Gene (PACRG) is a novel gene which is transcriptionally co-regulated with the parkin gene (PRKN) by a shared bi-directional promoter... - AcrB et al.: Obstinate contaminants in a picogram scale. One more bottleneck in the membrane protein structure pipelineGeorgios Psakis
Department of Chemistry, Philipps University Marburg, Hans Meerwein Strasse, 35033 Marburg, Germany
J Struct Biol 166:107-11. 2009..Two of these targets, the Na+ dependent D-glucose/D-galactose transporter (GluP-HP1174) and the carbon starvation protein A (CstA-HP1168), produced small crystals(<40 lm)... 
Loss of heterozygosity and copy number abnormality in clear cell renal cell carcinoma discovered by high-density affymetrix 10K single nucleotide polymorphism mapping arrayMarieta I Toma
Institute for Pathology, University of Technology Dresden, D 01307 Dresden, Germany
Neoplasia 10:634-42. 2008..As assessed by quantitative polymerase chain reaction, PARK2 and PACRG were down-regulated in 57% and 100%, respectively, and CSF1R was up-regulated in 69% of the cc-RCC cases (..- Proteasomal inhibition reduces parkin mRNA in PC12 and SH-SY5Y cellsAndreas Koch
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr 15, 81377 Munich, Germany
Parkinsonism Relat Disord 15:220-5. 2009..Since the mRNA of the parkin-coregulated gene PACRG paralleled the parkin mRNA at least partly, we suspect a promoter-driven mechanism... - Parkin-co-regulated gene (PACRG) product interacts with tubulin and microtubulesTakashi Ikeda
Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
FEBS Lett 582:1413-8. 2008Parkin-co-regulated gene (PACRG) is a gene that shares a bidirectional promoter with Parkinson's disease-related Parkin/Park2 gene. Recently, the PACRG gene product was implicated in the function of flagella... - A polysaccharide of Alloiococcus otitidis, a new pathogen of otitis media: chemical structure and synthesis of a neoglycoconjugate thereofSharif Arar
Department of Chemistry, University of Guelph, Guelph, ON, Canada N1G 2W1
Carbohydr Res 343:1079-90. 2008..GlcpA), of which the majority was amidically decorated with L-glutamic acid (Glu): {-->6)-beta-GalpNAc-(1-->4)-[Glup-->6]-beta-GlcpA-(1-->3)-beta-GlcpNAc-(1}n. Monomeric analysis performed on other A... - Regional and cellular localisation of Parkin co-regulated gene in developing and adult mouse brainKate M Brody
Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Melbourne, Victoria, 3052, Australia
Brain Res 1201:177-86. 2008Parkin Co-Regulated Gene (PACRG) is a novel gene that is oriented in a head-to-head array with parkin, and expression of the two genes is regulated by a shared bi-directional promoter... - Leprosy as a genetic model for susceptibility to common infectious diseasesAndrea Alter
McGill Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, 1650 Cedar Avenue, Montreal, H3G 1A4, QC, Canada
Hum Genet 123:227-35. 2008..scan in multi-case families from Vietnam led to the positional cloning of global genetic risk factors in the PARK2/PACRG and LTA genes... - Molecular analysis of the PArkin co-regulated gene and association with male infertilityGabrielle R Wilson
Bruce Lefroy Centre for Genetic Health Research, Murdoch Children s Research Institute, Melbourne, 3052, Victoria, Australia
Fertil Steril 93:2262-8. 2010To investigate the potential role of PArkin co-regulated gene (PACRG) in human male infertility. - HA-tagging of putative flagellar proteins in Chlamydomonas reinhardtii identifies a novel protein of intraflagellar transport complex BKarl Ferdinand Lechtreck
Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Cell Motil Cytoskeleton 66:469-82. 2009..The genes encoding nine of these not previously characterized plus the previously described PACRG protein were cloned, inserted into a vector adding a triple-HA tag to the C-terminus of the gene product, and .. - Patched1 haploinsufficiency impairs ependymal cilia function of the quaking viable mice, leading to fatal hydrocephalusChristina Gavino
Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec H3T1E2, Canada
Mol Cell Neurosci 47:100-7. 2011The quaking viable (qk(v)) mice harbor an autosomal recessive mutation that deletes the parkin co-regulated gene (pacrg) and parkin (park2) genes, and alters the expression of the quaking (qkI) gene... - Deletion of the Parkin co-regulated gene causes defects in ependymal ciliary motility and hydrocephalus in the quakingviable mutant mouseGabrielle R Wilson
Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Parkville 3052, Australia
Hum Mol Genet 19:1593-602. 2010..The deletion affects the expression of three genes; quaking (Qk), Parkin-coregulated gene (Pacrg) and parkin (Park2)... - Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasisRuben K Dagda
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Bioenerg Biomembr 41:473-9. 2009..We propose that PINK1, Omi/HtrA2 and parkin participate at different levels in mitochondrial quality control, converging through some overlapping and some distinct steps to maintain a common phenotype of healthy mitochondrial networks... - MEIG1 is essential for spermiogenesis in miceZhibing Zhang
Departments of Obstetrics and Gynecology and Biochemistry, Virginia Commonwealth University, Richmond, VA 23298, USA
Proc Natl Acad Sci U S A 106:17055-60. 2009..We also found that MEIG1 associates with the Parkin co-regulated gene (PACRG) protein, and that testicular PACRG protein is reduced in MEIG1-deficient mice... - Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and CaucasiansD R Velez
Dr John T Macdonald Foundation Department of Human Genetics and Miami Institute of Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, USA
Int J Tuberc Lung Dis 13:1068-76. 2009..Host defense factors may influence the development of active tuberculosis (TB)... - A new approach to pleural effusion in cats: markers for distinguishing transudates from exudatesAndrea Zoia
UCD School of Agriculture, Food Science and Veterinary Medicine, Dublin 4, Ireland
J Feline Med Surg 11:847-55. 2009..minus PE cholesterol concentration (CHOLg)), PE total nucleated cells count (TNCCp) and pleural fluid glucose (GLUp)... - Expression and localization of the Parkin co-regulated gene in mouse CNS suggests a role in ependymal cilia functionGabrielle R Wilson
Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
Neurosci Lett 460:97-101. 2009Parkin Co-Regulated Gene (PACRG) is a gene that shares a bi-directional promoter with the Parkinson's disease associated gene parkin... - Kit K641E oncogene up-regulates Sprouty homolog 4 and trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumoursPetra Gromova
Laboratory of Neurophysiology, Faculty of Medicine, Universite Libre de Bruxelles ULB, Brussels, Belgium
J Cell Mol Med 13:1536-48. 2009..Gja1/Cx43, Gpc6, Gpr133, Pacrg, Pde3a, Prkar2b, Prkcq/Pkce, Rasd2, Spry4 and Tpbg/5T4 were found to be up-regulated... - High-resolution genomic copy number profiling of glioblastoma multiforme by single nucleotide polymorphism DNA microarrayDong Yin
Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, Davis Building 5022 Room, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
Mol Cancer Res 7:665-77. 2009..The minimum common deleted region included PARK2, PACRG, QKI, and PDE10A genes... 
Axonemal localization of Chlamydomonas PACRG, a homologue of the human Parkin-coregulated gene productKazuho Ikeda
Department of Biological Sciences, Graduate School of Science, University of Tokyo, Bunkyo ku, Tokyo, Japan
Cell Motil Cytoskeleton 64:814-21. 2007A homologue of mammalian PACRG was identified in Sarkosyl-extracted Chlamydomonas axonemes as a protein that may interact with Rib72 (a component of the protofilament ribbon within the outer doublet microtubules)...- Parkin Co-Regulated Gene (PACRG) is regulated by the ubiquitin-proteasomal system and is present in the pathological features of Parkinsonian diseasesJuliet M Taylor
Bruce Lefroy Centre for Genetic Health Research, Murdoch Children s Research Institute, Melbourne, Victoria 3052, Australia
Neurobiol Dis 27:238-47. 2007..Parkin Co-Regulated Gene (PACRG) is a novel gene that was discovered because of its close genetic proximity to parkin and the two genes were .. - Cell type-specific upregulation of Parkin in response to ER stressHua Qin Wang
Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Antioxid Redox Signal 9:533-42. 2007..In parallel with these studies, similar upregulation of the parkin coregulated gene (PACRG)/gene adjacent to parkin (Glup) was also observed by ER stress... - Linkage of leprosy susceptibility to Parkinson's disease genesEllen Buschman
McGill Center for the Study of Host Resistance, Montreal, Canada
Int J Lepr Other Mycobact Dis 72:169-70. 2004..to the 5' regulatory promoter region shared by both the Parkinson's disease gene PARK2 and its co-regulated gene PACRG. The surprising discovery has important implications for the understanding of leprosy pathogenesis and for the .. - Deletion of the Parkin coregulated gene causes male sterility in the quaking(viable) mouse mutantDiego Lorenzetti
Graduate Program in Molecular and Human Genetics, Graduate School of Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 101:8402-7. 2004..Here, we demonstrate that the deletion of Pacrg is the cause of male sterility in the qk(v) mutant... - Expression of a novel gene, gluP, is essential for normal Bacillus subtilis cell division and contributes to glucose exportLili R Mesak
Department of Microbiology, Institute for Microbiology, Biochemistry and Genetics University of Erlangen Nuremberg, Staudstrasse 5, 91058 Erlangen, Germany
BMC Microbiol 4:13. 2004The Bacillus subtilis glucokinase operon was predicted to be comprised of the genes, yqgP (now named gluP), yqgQ, and glcK. We have previously established a role for glcK in glucose metabolism... - The neurological mutant quaking(viable) is Parkin deficientDiego Lorenzetti
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Room S413, Houston, Texas 77030, USA
Mamm Genome 15:210-7. 2004..We determined that the mouse Parkin gene, as well as the Parkin co-regulated gene ( Pacrg), lies within the qk(v) deletion... - It's a double knock-out! The quaking mouse is a spontaneous deletion of parkin and parkin co-regulated gene (PACRG)Paul J Lockhart
Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA
Mov Disord 19:101-4. 2004..entire promoter and first five coding exons of PRKN In addition, the recently described Parkin Co-Regulated Gene (PACRG) is completely deleted. Homozygous Quaking mice show a complete loss of PRKN and PACRG mRNA and protein... - Susceptibility to leprosy is associated with PARK2 and PACRGMarcelo T Mira
McGill Centre for the Study of Host Resistance and Department of Human Genetics, McGill University, 1650 Cedar Avenue, Montreal, PQ H3G1A4, Canada
Nature 427:636-40. 2004..overlapping the 5' regulatory region shared by the Parkinson's disease gene PARK2 and the co-regulated gene PACRG. Possession of as few as two of the 17 risk alleles was highly predictive of leprosy... - A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell deathYuzuru Imai
Laboratory for Motor System Neurodegeneration, RIKEN Brain Science Institute, Saitama 351 0198, Japan
J Biol Chem 278:51901-10. 2003..The gene product, termed Glup/PACRG, forms a large molecular chaperone complex containing heat shock proteins 70 and 90 and chaperonin components... - Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese populationMarcelo T Mira
McGill Centre for the Study of Host Resistance and Department of Human Genetics, McGill University, 1650 Cedar Avenue, Montreal, H3G 1A4 PQ, Canada
Nat Genet 33:412-5. 2003..Of seven microsatellite markers underlying the linkage peak, alleles of two markers (D6S1035 and D6S305) showed strong evidence for association with leprosy (P = 6.7 x 10(-4) and P = 5.9 x 10(-5), respectively)... - Identification of a novel gene linked to parkin via a bi-directional promoterAndrew B West
Program for Molecular Neuroscience, Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
J Mol Biol 326:11-9. 2003..6 Mb, antisense to parkin. We have tentatively named this novel gene Parkin co-regulated gene, or PACRG. A 35 bp site of bi-directional transcription activation within the common promoter was mapped using dual-.. - Genetic analysis of parkin co-regulated gene (PACRG) in patients with early-onset parkinsonismHao Deng
Department of Neurology, Baylor College of Medicine, 6501 Fannin Street, Houston, TX 77030, USA
Neurosci Lett 382:297-9. 2005Parkin co-regulated gene (PACRG) is a recently identified gene which is transcriptionally co-regulated with parkin gene (PRKN) by a shared bidirectional promoter... - Defining the breakpoints of the quaking(viable) mouse mutation reveals a duplication from a Parkin intronJason D Dapper
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Mov Disord 20:1369-74. 2005..The mutation has recently been shown to affect three genes in the region: Quaking (qk), Parkin-coregulated gene (Pacrg), and Parkin... - Mycobacterial infections: PARK2 and PACRG associations in leprosyE Schurr
Montreal General Hospital Research Institute, McGill Center for the Study of Host Resistance, Montreal, PQ, Canada
Tissue Antigens 69:231-3. 2007..An overview of investigations indicating an important role of host genetics, both major histocompatibility complex (MHC) and non-MHC, in leprosy... - Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosyAlexandre Alcais
Laboratoire de Genetique Humaine des Maladies Infectieuses, Institut National de la Sante et de la Recherche Medicale, U550, 75015 Paris, France
Nat Genet 39:517-22. 2007Host genetics has an important role in leprosy, and variants in the shared promoter region of PARK2 and PACRG were the first major susceptibility factors identified by positional cloning... - Deletion of the parkin and PACRG gene promoter in early-onset parkinsonismSuzanne Lesage
INSERM U679, Neurology and Experimental Therapeutics, Centre Hospitalier Universitaire CHU Pitié Salpêtrière, Assistance Publique Hopitaux de Paris AP HP, Paris, France
Hum Mutat 28:27-32. 2007..1-?_7+?del mutation. The promoter region is shared by parkin and the neighboring parkin coregulated gene (PACRG), which are oriented head-to-head and are transcribed on opposite DNA strands... - Genetic predisposition to leprosy: A major gene reveals novel pathways of immunity to Mycobacterium lepraeErwin Schurr
McGill Centre for the Study of Host Resistance, Department of Human Genetics and Medicine, McGill University, Montreal, PQ, Canada
Semin Immunol 18:404-10. 2006..We identified genetic variants in the shared promoter region of the PARK2 and PACRG genes as major risk factors of leprosy susceptibility... - PARK2/PACRG polymorphisms and susceptibility to typhoid and paratyphoid feverS Ali
Department of Infectious Diseases, Leiden University Medical Centre, The Netherlands
Clin Exp Immunol 144:425-31. 2006..Recently polymorphisms in PARK2/PACRG, a gene cluster linked to ubiquitination and proteasome-mediated protein degradation, were found to be associated .. - Association study of major risk single nucleotide polymorphisms in the common regulatory region of PARK2 and PACRG genes with leprosy in an Indian populationDheeraj Malhotra
National Centre of Applied Human Genetics, School of Life Sciences, Jawaharlal Nehru University, Lok Nayak Jai Prakash Hospital, New Delhi 110067, India
Eur J Hum Genet 14:438-42. 2006Single nucleotide polymorphisms (SNPs) in the regulatory region shared by PARK2 and PACRG have been identified as major risk factors for leprosy susceptibility in two ethnically distinct populations... - Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemiaXabier Agirre
Foundation for Applied Medical Research, Division of Cancer, Area of Cell Therapy and Hematology Service, Clinica Universitaria, Universidad de Navarra, Pamplona, Spain
Int J Cancer 118:1945-53. 2006..PARK2 is linked to a novel described PACRG gene by a bidirectional promoter containing a defined CpG island in its common promoter region... - The Parkin co-regulated gene product, PACRG, is an evolutionarily conserved axonemal protein that functions in outer-doublet microtubule morphogenesisHelen R Dawe
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
J Cell Sci 118:5421-30. 2005..We identified the Parkin co-regulated gene, or PACRG, from such a screen. Male mice deficient in PACRG are sterile, but its function has been little explored... - Small regions of overlapping deletions on 6q26 in human astrocytic tumours identified using chromosome 6 tile path array-CGHK Ichimura
Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Oncogene 25:1261-71. 2006..One was 1,002 kb in size and contained PACRG and QKI, while the second was 199 kb and harbours a single gene, ARID1B... - The gluEMP operon from Zymomonas mobilis encodes a high-affinity glutamate carrier with similarity to binding-protein-dependent transport systemsN Peekhaus
Institut für Biotechnologie I, Forschungszentrum Julich GmbH, Germany
Arch Microbiol 165:325-32. 1996..Three clustered genes (gluE, gluM, and gluP) close to ghe grp gene, but on the opposite strand, were identified...
Research Grants
- GENETIC DISSECTION OF MYCOBACTERIAL INFECTIONErwin Schurr; Fiscal Year: 2005..tuberculosis through an exposed population. ..