PAAF1

Summary

Gene Symbol: PAAF1
Description: proteasomal ATPase associated factor 1
Alias: PAAF, Rpn14, WDR71, proteasomal ATPase-associated factor 1, WD repeat domain 71, WD repeat-containing protein 71
Species: human
Products:     PAAF1

Top Publications

  1. Lassot I, Latreille D, Rousset E, Sourisseau M, Linares L, Chable Bessia C, et al. The proteasome regulates HIV-1 transcription by both proteolytic and nonproteolytic mechanisms. Mol Cell. 2007;25:369-83 pubmed
    ..Tat switched the proteasome to a nonproteolytic mode by recruiting a proteasome-associated protein, PAAF1, which favors proteasome dissociation into 19S and 20S particles...
  2. Park Y, Hwang Y, Lee J, Seo S, Yoon S, Yoon J. Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. Mol Cell Biol. 2005;25:3842-53 pubmed
    ..Hence the protein was named proteasomal ATPase-associated factor 1 (PAAF1)...
  3. Funakoshi M, Tomko R, Kobayashi H, Hochstrasser M. Multiple assembly chaperones govern biogenesis of the proteasome regulatory particle base. Cell. 2009;137:887-99 pubmed publisher
    ..Larger Hsm3-containing complexes include two additional proteins, Nas6 and Rpn14, which function as assembly chaperones as well...
  4. Nahar A, Fu X, Polovin G, Orth J, Park S. Two alternative mechanisms regulate the onset of chaperone-mediated assembly of the proteasomal ATPases. J Biol Chem. 2019;294:6562-6577 pubmed publisher
    ..to as 'Rpt ring', assembles through six ATPase subunits (Rpt1-Rpt6) individually binding to specific chaperones (Rpn14, Nas6, Nas2, and Hsm3)...
  5. Grishin A, Ajamian E, Zhang L, Rouiller I, Bostina M, Cygler M. Protein-protein interactions in the β-oxidation part of the phenylacetate utilization pathway: crystal structure of the PaaF-PaaG hydratase-isomerase complex. J Biol Chem. 2012;287:37986-96 pubmed publisher
    ..We have determined the structure of the PaaFG complex and determined that although individually PaaF and PaaG are similar to enzymes from the fatty acid β-oxidation pathway, the structure of the complex is ..
  6. Fu X, Sokolova V, Webb K, Old W, Park S. Ubiquitin-dependent switch during assembly of the proteasomal ATPases mediated by Not4 ubiquitin ligase. Proc Natl Acad Sci U S A. 2018;115:13246-13251 pubmed publisher
    ..proteins assemble into the hexameric "Rpt ring" through binding to their cognate chaperones: Nas2, Hsm3, Nas6, and Rpn14. Here, we show that Rpt ring assembly employs a specific ubiquitination-mediated control...
  7. Ramírez Plaza C, Domínguez López M, Blanco Reina F. Thyroid metastasis as initial presentation of clear cell renal carcinoma. Int J Surg Case Rep. 2015;10:101-3 pubmed publisher
    ..A 62-year woman who underwent a cervical ultrasonography and a PAAF biopsy reporting atypical follicular proliferation with a few intranuclear vacuoles "suggestive" of thyroid ..
  8. Chen R, Wu X, Jin H, Wang B, Ma M, Zhao B. Assessment of Left Atrial Appendage Morphology and Function in Patients with Non-valvular Paroxysmal Atrial Fibrillation with Different Rhythms Using Real-Time 3D Transesophageal Echocardiography. Ultrasound Med Biol. 2016;42:118-24 pubmed publisher
    ..morphology and function of the left atrial appendage (LAA) in different rhythms of paroxysmal atrial fibrillation (PaAF) patients using real-time 3D transesophageal echocardiography...
  9. Huang Z, Yu S, Liang H, Zhou J, Yan H, Chen T, et al. Outcome benefit of abdominal paracentesis drainage for severe acute pancreatitis patients with serum triglyceride elevation by decreasing serum lipid metabolites. Lipids Health Dis. 2016;15:110 pubmed publisher
    ..HTG)-induced SAP patients with triglyceride (TG) elevation and pancreatitis-associated ascitic fluid (PAAF) was recruited from May 2010 to May 2015 and included in this study...

More Information

Publications22

  1. Li F, Tian G, Langager D, Sokolova V, Finley D, Park S. Nucleotide-dependent switch in proteasome assembly mediated by the Nas6 chaperone. Proc Natl Acad Sci U S A. 2017;114:1548-1553 pubmed publisher
    ..Previous work has shown that the chaperones Rpn14, Nas6, Hsm3, and Nas2 each bind a specific ATPase subunit of the base and antagonize base-CP interaction...
  2. Clop A, Sharaf A, Castelló A, Ramos Onsins S, Cirera S, Mercadé A, et al. Identification of protein-damaging mutations in 10 swine taste receptors and 191 appetite-reward genes. BMC Genomics. 2016;17:685 pubmed publisher
    ..334 variants were present in only one breed and at predicted alternative allele frequency (pAAF)???0.1. The Asian pigs and the wild boars showed the largest proportion of breed specific variants...
  3. Kallscheuer N, Gätgens J, Lübcke M, Pietruszka J, Bott M, Polen T. Improved production of adipate with Escherichia coli by reversal of ?-oxidation. Appl Microbiol Biotechnol. 2017;101:2371-2382 pubmed publisher
    ..Expression of paaJ, paaH, paaF, dcaA, and tesB in E...
  4. Ponnappan S, Ovaa H, Ponnappan U. Lower expression of catalytic and structural subunits of the proteasome contributes to decreased proteolysis in peripheral blood T lymphocytes during aging. Int J Biochem Cell Biol. 2007;39:799-809 pubmed
    ..of catalytic, structural and regulatory subunits, with no change in that of the 11S activator or the inhibitor PAAF1. Oxidative modification, such as carbonylation and lipid-peroxidation, of proteasomal subunits was also detected ..
  5. Kaneko T, Hamazaki J, Iemura S, Sasaki K, Furuyama K, Natsume T, et al. Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones. Cell. 2009;137:914-25 pubmed publisher
    ..The process of base formation starts from association of the p28-Rpt3-Rpt6-Rpn14 complex with the S5b-Rpt1-Rpt2-Rpn1 complex, followed by incorporation of the p27-Rpt5-Rpt4 complex and Rpn2, ..
  6. Lu Y, Wu J, Dong Y, Chen S, Sun S, Ma Y, et al. Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol Cell. 2017;67:322-333.e6 pubmed publisher
    ..of a heterohexameric ring of AAA-ATPases, which is guided by at least four RP assembly chaperones in mammals: PAAF1, p28/gankyrin, p27/PSMD9, and S5b...
  7. Sun L, Qu X, Chen L, Chen X, Zheng G, Wang Z, et al. High molecular weight fibroblast growth factor-2 as a promising prognostic biomarker to predict the occurrence of heart failure in atrial fibrillation patients. Heart Vessels. 2017;32:1506-1512 pubmed publisher
    ..Subjects diagnosed with paroxysmal AF (Group paAF), persistent AF (Group peAF) and sinus rhythm (Group SR) were enrolled in the study...
  8. Kim S, Nishide A, Saeki Y, Takagi K, Tanaka K, Kato K, et al. New crystal structure of the proteasome-dedicated chaperone Rpn14 at 1.6 Å resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012;68:517-21 pubmed publisher
    ..b>Rpn14, an assembly chaperone for ATPase-ring formation, specifically recognizes the ATPase subunit Rpt6...
  9. TAMBOLI R, Hajri T, Jiang A, Marks Shulman P, Williams D, Clements R, et al. Reduction in inflammatory gene expression in skeletal muscle from Roux-en-Y gastric bypass patients randomized to omentectomy. PLoS ONE. 2011;6:e28577 pubmed publisher
    ..expression of genes driving protein turnover (IGFN1, FBXW10) in both groups over time and increased expression of PAAF1 in the non-omentectomy group at 12 months...
  10. Tomko R, Funakoshi M, Schneider K, Wang J, Hochstrasser M. Heterohexameric ring arrangement of the eukaryotic proteasomal ATPases: implications for proteasome structure and assembly. Mol Cell. 2010;38:393-403 pubmed publisher
    ..potential RP assembly intermediate that includes four ATPases (Rpt6-Rpt3-Rpt4-Rpt5) and their cognate chaperones (Rpn14, Nas6, and Nas2)...
  11. Sun S, Liu S, Zhang Z, Zeng W, Sun C, Tao T, et al. Phosphatase UBLCP1 controls proteasome assembly. Open Biol. 2017;7: pubmed publisher
  12. Nakamura M, Basavarajaiah P, Rousset E, Beraud C, Latreille D, Henaoui I, et al. Spt6 levels are modulated by PAAF1 and proteasome to regulate the HIV-1 LTR. Retrovirology. 2012;9:13 pubmed publisher
    Tat-mediated activation of the HIV-1 promoter depends upon a proteasome-associated factor, PAAF1, which dissociates 26S proteasome to produce 19S RP that is essential for transcriptional elongation...
  13. Lee S, Moon J, Yoon S, Yoon J. Stable incorporation of ATPase subunits into 19 S regulatory particle of human proteasome requires nucleotide binding and C-terminal tails. J Biol Chem. 2012;287:9269-79 pubmed publisher
    ..Coexpression of the base assembly chaperones S5b and PAAF1 with mutant Rpt1 and Rpt6, respectively, relieves assembly inhibition of mutant Rpts by facilitating their ..