p90rsk

Summary

Gene Symbol: p90rsk
Description: ribosomal protein S6 kinase A1
Alias: HU-1, MAPKAPK1A, RSK, RSK1, p90Rsk, ribosomal protein S6 kinase alpha-1, 90 kDa ribosomal protein S6 kinase 1, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1a, MAPKAP kinase 1a, MAPKAPK-1a, RSK-1, S6K-alpha 1, dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1), p90-RSK 1, p90RSK1, p90S6K, ribosomal S6 kinase 1, ribosomal protein S6 kinase, 90kDa, polypeptide 1
Species: human
Products:     p90rsk

Top Publications

  1. Dehan E, Bassermann F, Guardavaccaro D, Vasiliver Shamis G, Cohen M, Lowes K, et al. betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis. Mol Cell. 2009;33:109-16 pubmed publisher
    ..Phosphorylation of the BimEL degron was executed by Rsk1/2 and promoted by the Erk1/2-mediated phosphorylation of BimEL on Ser69...
  2. Chen R, Abate C, Blenis J. Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase. Proc Natl Acad Sci U S A. 1993;90:10952-6 pubmed
    ..evidence that two growth-regulated, nucleus- and cytoplasm-localized protein kinases, 90-kDa ribosomal S6 kinase (RSK) and mitogen-activated protein kinase (MAP kinase), contribute to the serum-induced phosphorylation of c-Fos...
  3. Dalby K, Morrice N, Caudwell F, Avruch J, Cohen P. Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK. J Biol Chem. 1998;273:1496-505 pubmed
    Mitogen-activated protein kinase-activated protein kinase-1 (MAPKAP-K1; also known as p90rsk) contains two protein kinase domains in a single polypeptide...
  4. Richards S, Fu J, Romanelli A, Shimamura A, Blenis J. Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK. Curr Biol. 1999;9:810-20 pubmed
    The rsk1 gene encodes the 90 kDa ribosomal S6 kinase 1 (RSK1) protein, which contains two kinase domains...
  5. Roux P, Richards S, Blenis J. Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. Mol Cell Biol. 2003;23:4796-804 pubmed
    ..In this report we show that RSK1 and ERK1/2 form a complex in quiescent HEK293 cells that transiently dissociates upon mitogen stimulation...
  6. Lara R, Mauri F, Taylor H, Derua R, Shia A, Gray C, et al. An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis. Oncogene. 2011;30:3513-21 pubmed publisher
    ..In particular, ribosomal S6 kinase 1 (RSK1) silencing increased, whereas RSK2 and RSK4 downregulation inhibited cell motility...
  7. Joel P, Smith J, Sturgill T, Fisher T, Blenis J, Lannigan D. pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167. Mol Cell Biol. 1998;18:1978-84 pubmed
    ..Taken together, our results strongly suggest that pp90rsk1 phosphorylates Ser-167 of the human ER in vivo and that Ser-167 aids in regulating the transcriptional activity of AF-1 in the ER. ..
  8. Wang X, Li W, Williams M, Terada N, Alessi D, Proud C. Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. EMBO J. 2001;20:4370-9 pubmed
    ..of members of the AGC kinase family; we show that two such kinases, p70 S6 kinase (regulated via mTOR) and p90(RSK1) (activated by Erk), phosphorylate eEF2k at a conserved serine and inhibit its activity...
  9. Roux P, Ballif B, Anjum R, Gygi S, Blenis J. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci U S A. 2004;101:13489-94 pubmed
    ..of tuberin and collaborates with the nutrient-sensing pathway to regulate mTOR effectors, such as p70 ribosomal S6 kinase 1 (S6K1)...
  10. Gao X, Chaturvedi D, Patel T. p90 ribosomal S6 kinase 1 (RSK1) and the catalytic subunit of protein kinase A (PKA) compete for binding the pseudosubstrate region of PKAR1alpha: role in the regulation of PKA and RSK1 activities. J Biol Chem. 2010;285:6970-9 pubmed publisher
    Previously we showed that the inactive form of p90 ribosomal S6 kinase 1 (RSK1) interacts with the regulatory subunit, PKARIalpha, of protein kinase A (PKA), whereas the active RSK1 interacts with the catalytic subunit (PKAc) of PKA...

Detail Information

Publications104 found, 100 shown here

  1. Dehan E, Bassermann F, Guardavaccaro D, Vasiliver Shamis G, Cohen M, Lowes K, et al. betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis. Mol Cell. 2009;33:109-16 pubmed publisher
    ..Phosphorylation of the BimEL degron was executed by Rsk1/2 and promoted by the Erk1/2-mediated phosphorylation of BimEL on Ser69...
  2. Chen R, Abate C, Blenis J. Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase. Proc Natl Acad Sci U S A. 1993;90:10952-6 pubmed
    ..evidence that two growth-regulated, nucleus- and cytoplasm-localized protein kinases, 90-kDa ribosomal S6 kinase (RSK) and mitogen-activated protein kinase (MAP kinase), contribute to the serum-induced phosphorylation of c-Fos...
  3. Dalby K, Morrice N, Caudwell F, Avruch J, Cohen P. Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK. J Biol Chem. 1998;273:1496-505 pubmed
    Mitogen-activated protein kinase-activated protein kinase-1 (MAPKAP-K1; also known as p90rsk) contains two protein kinase domains in a single polypeptide...
  4. Richards S, Fu J, Romanelli A, Shimamura A, Blenis J. Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK. Curr Biol. 1999;9:810-20 pubmed
    The rsk1 gene encodes the 90 kDa ribosomal S6 kinase 1 (RSK1) protein, which contains two kinase domains...
  5. Roux P, Richards S, Blenis J. Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. Mol Cell Biol. 2003;23:4796-804 pubmed
    ..In this report we show that RSK1 and ERK1/2 form a complex in quiescent HEK293 cells that transiently dissociates upon mitogen stimulation...
  6. Lara R, Mauri F, Taylor H, Derua R, Shia A, Gray C, et al. An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis. Oncogene. 2011;30:3513-21 pubmed publisher
    ..In particular, ribosomal S6 kinase 1 (RSK1) silencing increased, whereas RSK2 and RSK4 downregulation inhibited cell motility...
  7. Joel P, Smith J, Sturgill T, Fisher T, Blenis J, Lannigan D. pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167. Mol Cell Biol. 1998;18:1978-84 pubmed
    ..Taken together, our results strongly suggest that pp90rsk1 phosphorylates Ser-167 of the human ER in vivo and that Ser-167 aids in regulating the transcriptional activity of AF-1 in the ER. ..
  8. Wang X, Li W, Williams M, Terada N, Alessi D, Proud C. Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. EMBO J. 2001;20:4370-9 pubmed
    ..of members of the AGC kinase family; we show that two such kinases, p70 S6 kinase (regulated via mTOR) and p90(RSK1) (activated by Erk), phosphorylate eEF2k at a conserved serine and inhibit its activity...
  9. Roux P, Ballif B, Anjum R, Gygi S, Blenis J. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci U S A. 2004;101:13489-94 pubmed
    ..of tuberin and collaborates with the nutrient-sensing pathway to regulate mTOR effectors, such as p70 ribosomal S6 kinase 1 (S6K1)...
  10. Gao X, Chaturvedi D, Patel T. p90 ribosomal S6 kinase 1 (RSK1) and the catalytic subunit of protein kinase A (PKA) compete for binding the pseudosubstrate region of PKAR1alpha: role in the regulation of PKA and RSK1 activities. J Biol Chem. 2010;285:6970-9 pubmed publisher
    Previously we showed that the inactive form of p90 ribosomal S6 kinase 1 (RSK1) interacts with the regulatory subunit, PKARIalpha, of protein kinase A (PKA), whereas the active RSK1 interacts with the catalytic subunit (PKAc) of PKA...
  11. Smith J, Poteet Smith C, Malarkey K, Sturgill T. Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo. J Biol Chem. 1999;274:2893-8 pubmed
    ..GST)-fusion proteins containing the carboxyl-terminal tails of three p90 ribosomal S6 kinase (RSK) isozymes (RSK1, RSK2, and RSK3) interacted with extracellular signal-regulated kinase (ERK) but not c-Jun-NH2-kinase (JNK) or p38 ..
  12. Jensen C, Buch M, Krag T, Hemmings B, Gammeltoft S, Frodin M. 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1. J Biol Chem. 1999;274:27168-76 pubmed
    ..Similarly, two other members of the RSK family, RSK1 and RSK3, were partially activated by PDK1 in COS7 cells...
  13. Chaturvedi D, Poppleton H, Stringfield T, Barbier A, Patel T. Subcellular localization and biological actions of activated RSK1 are determined by its interactions with subunits of cyclic AMP-dependent protein kinase. Mol Cell Biol. 2006;26:4586-600 pubmed
    Cyclic AMP (cAMP)-dependent protein kinase (PKA) and ribosomal S6 kinase 1 (RSK1) share several cellular proteins as substrates...
  14. Anjum R, Blenis J. The RSK family of kinases: emerging roles in cellular signalling. Nat Rev Mol Cell Biol. 2008;9:747-58 pubmed publisher
    The 90 kDa ribosomal S6 kinase (RSK) family of proteins is a group of highly conserved Ser/Thr kinases that regulate diverse cellular processes, such as cell growth, cell motility, cell survival and cell proliferation...
  15. Gao X, Patel T. Regulation of protein kinase A activity by p90 ribosomal S6 kinase 1. J Biol Chem. 2009;284:33070-8 pubmed publisher
    ..we reported that the catalytic subunit of cAMP-dependent protein kinase (PKAc) binds to the active p90 ribosomal S6 kinase 1 (RSK1) (Chaturvedi, D., Poppleton, H. M., Stringfield, T., Barbier, A., and Patel, T. B. (2006) Mol. Cell...
  16. Shimamura A, Ballif B, Richards S, Blenis J. Rsk1 mediates a MEK-MAP kinase cell survival signal. Curr Biol. 2000;10:127-35 pubmed
    ..We identify here a pro-survival role for the serine/threonine kinase Rsk1, a downstream target of the MEK-MAP kinase signaling pathway...
  17. Ikuta M, Kornienko M, Byrne N, Reid J, Mizuarai S, Kotani H, et al. Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors. Protein Sci. 2007;16:2626-35 pubmed
    ..b>RSK1, a member of the RSK family, contains two distinct kinase domains in a single polypeptide chain, the regulatory C-..
  18. Suzuki T, Matsuda S, Tsuzuku J, Yoshida Y, Yamamoto T. A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob. Genes Cells. 2001;6:131-8 pubmed
    ..Among the known kinases with molecular mass around 95 kDa, p90rsk1 associates with Tob in vitro and in vivo, and phosphorylates Tob at least in vitro...
  19. Sawicka K, Pyronneau A, Chao M, Bennett M, Zukin R. Elevated ERK/p90 ribosomal S6 kinase activity underlies audiogenic seizure susceptibility in fragile X mice. Proc Natl Acad Sci U S A. 2016;113:E6290-E6297 pubmed
    ..We show that in fragile X mice, S6 is regulated by ERK via the "alternative" S6 kinase p90-ribosomal S6 kinase (RSK), as evidenced by the site of elevated phosphorylation and the finding that ERK inhibition corrects elevated RSK ..
  20. Wong E, Schaefer A, Landreth G, Lemmon V. Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1. J Biol Chem. 1996;271:18217-23 pubmed
    ..that the L1 kinase activity from PC12 cells that phosphorylated this site was co-eluted with the S6 kinase, p90(rsk)...
  21. Chen J, Volpi S, Aguilera G. Anti-apoptotic actions of vasopressin in H32 neurons involve MAP kinase transactivation and Bad phosphorylation. Exp Neurol. 2008;211:529-38 pubmed publisher
    ..The data suggest that VP has anti-apoptotic activity in neurons and that VP may act as a neuroprotective agent in the brain. ..
  22. Mendoza Arnau A, Vallecillo Capilla M, Cabrerizo Vílchez M, Rosales Leal J. Topographic characterisation of dental implants for commercial use. Med Oral Patol Oral Cir Bucal. 2016;21:e631-6 pubmed
    ..Roughness parameters obtained were: Ra, Rq, Rv, Rp, Rt, Rsk and Rku. The results were analysed using single-factor ANOVA and Student-Neuman-Keuls (p<0.05) tests...
  23. Casalvieri K, Matheson C, Backos D, Reigan P. Selective Targeting of RSK Isoforms in Cancer. Trends Cancer. 2017;3:302-312 pubmed publisher
    The p90 ribosomal S6 kinase family (RSK1-4) is a group of highly conserved Ser/Thr kinases that act as downstream effectors of the Ras/Raf/MEK/ERK signaling pathway...
  24. Gordiienko I, Shlapatska L, Kholodniuk V, Sklyarenko L, Gluzman D, Clark E, et al. The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling. PLoS ONE. 2017;12:e0185940 pubmed publisher
    ..While CD150 and CD180 coligation resulted in reduced phosphorylation of Akt, ERK1/2, c-Jun, RSK, p70S6K, S6RP, and 4E-BP; it led to complete blocking of mTOR and p38MAPK phosphorylation...
  25. Diggle T, Subkhankulova T, Lilley K, Shikotra N, Willis A, Redpath N. Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity. Biochem J. 2001;353:621-6 pubmed
    ..Our data demonstrate an important role for the phosphorylation of Ser-499 in the activation of eEF-2K by PKA and the inhibition of protein synthesis. ..
  26. Anjum R, Roux P, Ballif B, Gygi S, Blenis J. The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling. Curr Biol. 2005;15:1762-7 pubmed
    ..We demonstrate that DAPK is a novel target of p90 ribosomal S6 kinases (RSK) 1 and 2, downstream effectors of ERK1/2...
  27. Aiken J, Birot O. The Vascular Endothelial Growth Factor-A phosphorylates Murine Double Minute-2 on its Serine 166 via the Extracellular Signal-Regulated Kinase 1/2 and p90 Ribosomal S6 Kinase in primary human endothelial cells. Biochem Biophys Res Commun. 2016;478:1548-54 pubmed publisher
    ..of VEGF-receptor-2, Mdm2, Akt, Extracellular Signal-Regulated Kinase 1/2 (ERK1/2), and p90 Ribosomal S6 Kinase (p90RSK) proteins...
  28. Rivera V, Miranti C, Misra R, Ginty D, Chen R, Blenis J, et al. A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity. Mol Cell Biol. 1993;13:6260-73 pubmed
  29. Lagares Tena L, García Monclús S, López Alemany R, Almacellas Rabaiget O, Huertas Martínez J, Sáinz Jaspeado M, et al. Caveolin-1 promotes Ewing sarcoma metastasis regulating MMP-9 expression through MAPK/ERK pathway. Oncotarget. 2016;7:56889-56903 pubmed publisher
    ..CAV1-silenced cells showed reduced levels of p-RSK1 and treatment with U0126 provoked the same effect...
  30. Ludwik K, Campbell J, Li M, Li Y, Sandusky Z, Pasic L, et al. Development of a RSK Inhibitor as a Novel Therapy for Triple-Negative Breast Cancer. Mol Cancer Ther. 2016;15:2598-2608 pubmed
    ..Triple-negative breast cancer (TNBC) frequently metastasizes and high levels of activated p90RSK (RSK), a downstream MEK-ERK1/2 effector, are found in TNBC...
  31. Sutavani R, Phair I, Barker R, McFarlane A, Shpiro N, Lang S, et al. Differential control of Toll-like receptor 4-induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases. J Biol Chem. 2018;293:2302-2317 pubmed publisher
    ..This observation highlights fundamental differences in the signaling controlling IL-10 production in B cells and macrophages, even though these two cell types respond to a common TLR stimulus. ..
  32. Lee Y, Gotoh A, Kwon H, You M, Kohli L, Mantel C, et al. Enhancement of intracellular signaling associated with hematopoietic progenitor cell survival in response to SDF-1/CXCL12 in synergy with other cytokines. Blood. 2002;99:4307-17 pubmed
    ..SDF-1 alpha induced transient activation of extracellular stress-regulated kinase (ERK1/2), ribosomal S6 kinase (p90RSK) and Akt, molecules implicated in cell survival...
  33. Heo K, Le N, Cushman H, Giancursio C, Chang E, Woo C, et al. Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function. J Clin Invest. 2015;125:1299-310 pubmed publisher
    ..Here, we determined that d-flow activated the serine/threonine kinase p90RSK, which subsequently phosphorylated threonine 368 (T368) of SENP2...
  34. Park Y, Liu Z, Vasamsetti B, Cho N. The ERK1/2 and mTORC1 Signaling Pathways Are Involved in the Muscarinic Acetylcholine Receptor-Mediated Proliferation of SNU-407 Colon Cancer Cells. J Cell Biochem. 2016;117:2854-2863 pubmed publisher
    ..Previously, we showed that mAChRs stimulate the MEK1/2-ERK1/2-RSK pathway in SNU-407 colon cancer cells and subsequently promote cell proliferation...
  35. Houles T, Roux P. Defining the role of the RSK isoforms in cancer. Semin Cancer Biol. 2018;48:53-61 pubmed publisher
    The 90kDa ribosomal S6 kinase (RSK) family is a group of Ser/Thr protein kinases (RSK1-4) that function downstream of the Ras/mitogen-activated protein kinase (MAPK) signalling pathway...
  36. Park T. Complete genome sequence of DU_RP_II, a novel Ralstonia solanacearum phage of the family Podoviridae. Arch Virol. 2018;163:269-271 pubmed publisher
    ..17% and 38 predicted coding sequences. The phage showed homology to the RSK1 phage in four coding sequences, but it was concluded that the phage differed from previously reported Ralstonia ..
  37. Zuzow N, Ghosh A, Leonard M, Liao J, Yang B, Bennett E. Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches. Mol Biol Cell. 2018;: pubmed publisher
    ..Further, loss of Ltn1 function results in hyperactivation of RSK1/2 signaling without impacting RSK1/2 protein turnover...
  38. Heilker R, Freuler F, Pulfer R, Di Padova F, Eder J. All three IkappaB isoforms and most Rel family members are stably associated with the IkappaB kinase 1/2 complex. Eur J Biochem. 1999;259:253-61 pubmed
    ..All three activities correspond to known IkappaB kinases: the mitogen-activated 90 kDa ribosomal S6 kinase (p90rsk1), the IkappaB kinase 1/2 complex (IKK1/2) and casein kinase II (CK II)...
  39. Carretero L, Llavona P, López Hernández A, Casado P, Cutillas P, de la Peña P, et al. ERK and RSK are necessary for TRH-induced inhibition of r-ERG potassium currents in rat pituitary GH3 cells. Cell Signal. 2015;27:1720-30 pubmed publisher
    ..on r-ERG current was also impaired when cells were transfected with any of two different siRNAs mixtures against Rsk1. However, treatment of GH3 cells with 20nM EGF for 5min, which causes ERK and RSK activation, had no effect on the ..
  40. Avey D, Tepper S, Li W, Turpin Z, ZHU F. Phosphoproteomic Analysis of KSHV-Infected Cells Reveals Roles of ORF45-Activated RSK during Lytic Replication. PLoS Pathog. 2015;11:e1004993 pubmed publisher
    ..previously shown that KSHV ORF45 contributes to the sustained activation of both ERK and p90 ribosomal S6 kinase (RSK, a major functional mediator of ERK/MAPK signaling) during KSHV lytic replication...
  41. Edgar A, Trost M, Watts C, Zaru R. A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870. Biosci Rep. 2014;34: pubmed
    ..By comparing two different inhibitors of the Rsk (p90 ribosomal S6 kinase) kinases, we found that the increasingly used compound BI-D1870 had biological effects in ..
  42. Yin X, Cheng G, Guo H, Wang Q, Li Y, Zhang H. Single cell transcriptome profiling revealed differences in gene expression during oocyte maturation in Haimen white goats. Genet Mol Res. 2017;16: pubmed publisher
    ..Further study of these genes will be of great importance for improving the reproductive performance of Haimen white goats. ..
  43. Dumont J, Umbhauer M, Rassinier P, Hanauer A, Verlhac M. p90Rsk is not involved in cytostatic factor arrest in mouse oocytes. J Cell Biol. 2005;169:227-31 pubmed
    ..In Xenopus oocytes, p90Rsk (ribosomal S6 kinase), a MAPK substrate, is the main mediator of CSF activity...
  44. Cheng F, Sawant T, Lan K, Lu C, Jung J, Gao S. Screening of the Human Kinome Identifies MSK1/2-CREB1 as an Essential Pathway Mediating Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication during Primary Infection. J Virol. 2015;89:9262-80 pubmed publisher
    ..CREB1 was not activated through the classic cAMP/protein kinase A (cAMP/PKA) pathway or via the AKT, MK2, and RSK pathways. Rather, CREB1 was activated by the mitogen- and stress-activated protein kinases 1 and 2 (MSK1/2)...
  45. Te Molder L, Sonnenberg A. PKD2 and RSK1 Regulate Integrin β4 Phosphorylation at Threonine 1736. PLoS ONE. 2015;10:e0143357 pubmed publisher
    ..Moreover, phosphorylation of β4-T1736 is enhanced by overexpression of wild-type RSK1, while it is reduced by the expression of kinase-inactive RSK1 or by siRNA-mediated depletion of RSK1...
  46. Pedrazza L, Cubillos Rojas M, de Mesquita F, Luft C, Cunha A, Rosa J, et al. Mesenchymal stem cells decrease lung inflammation during sepsis, acting through inhibition of the MAPK pathway. Stem Cell Res Ther. 2017;8:289 pubmed publisher
    ..and showed that this reduction was directly related to the ability of MSCs to inhibit phosphorylation of ERK, RSK, and p38, enzymes that belong to the family of mitogen-activated protein kinases (MAPKs)...
  47. Shi G, Yang W, Jin L, Matter M, Ramos J. RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases. Proc Natl Acad Sci U S A. 2018;115:E190-E199 pubmed publisher
    ..p90 ribosomal S6 kinases) have emerged as central regulators of cell migration; however, the mechanisms mediating RSK-dependent motility remain incompletely understood...
  48. Czaplinska D, Górska M, Mieczkowski K, Peszyńska Sularz G, Zaczek A, Romanska H, et al. RSK1 promotes murine breast cancer growth and metastasis. Folia Histochem Cytobiol. 2018;56:11-20 pubmed publisher
    ..Herein we examined an involvement of RSK1 (p90 ribosomal S6 kinase 1) in a regulation of TNBC growth and metastatic spread in an animal model, which closely imitates human ..
  49. Campbell R, Bhat Nakshatri P, Patel N, Constantinidou D, Ali S, Nakshatri H. Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance. J Biol Chem. 2001;276:9817-24 pubmed
    ..Taken together, these results define a molecular link between activation of the PI 3-kinase/AKT survival pathways, hormone-independent activation of ERalpha, and inhibition of tamoxifen-induced apoptotic regression. ..
  50. Hers I, Wherlock M, Homma Y, Yagisawa H, Tavare J. Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells. J Biol Chem. 2006;281:4762-70 pubmed
    ..These results demonstrate that p122RhoGAP Ser-322 acts as an integrator of signal transduction in a manner dependent on the cellular context. ..
  51. Sulzmaier F, Young Robbins S, Jiang P, Geerts D, Prechtl A, Matter M, et al. RSK2 activity mediates glioblastoma invasiveness and is a potential target for new therapeutics. Oncotarget. 2016;7:79869-79884 pubmed publisher
    ..Importantly, inhibition of RSK2 by either RSK inhibitors or shRNA silencing impairs invasion and combining RSK2 inhibitors with temozolomide improves efficacy in ..
  52. Han S, Lim T, Kim J, Yang H, Oh D, Yoon Park J, et al. The Ginsenoside Derivative 20(S)-Protopanaxadiol Inhibits Solar Ultraviolet Light-Induced Matrix Metalloproteinase-1 Expression. J Cell Biochem. 2017;118:3756-3764 pubmed publisher
    ..Two upstream signaling pathways for AP-1, the MEK1/2-ERK1/2-p90RSK and MEK3/6-p38 pathways, were also suppressed...
  53. Versteeg H, Sørensen B, Slofstra S, Van den Brande J, Stam J, van Bergen en Henegouwen P, et al. VIIa/tissue factor interaction results in a tissue factor cytoplasmic domain-independent activation of protein synthesis, p70, and p90 S6 kinase phosphorylation. J Biol Chem. 2002;277:27065-72 pubmed
    ..Here we show that FVIIa induces a transient phosphorylation of p70/p85(S6K) and p90(RSK) in BHK cells stably transfected with either full-length TF or with a cytoplasmic domain-truncated TF but not in ..
  54. Thomas G, Rumbaugh G, Harrar D, Huganir R. Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission. Proc Natl Acad Sci U S A. 2005;102:15006-11 pubmed
    ..We report here that the protein kinase ribosomal S6 kinase (RSK)2, a downstream target of ERK, uses a C-terminal motif to bind several PDZ domain proteins in heterologous systems ..
  55. Roffé M, Lupinacci F, Soares L, Hajj G, Martins V. Two widely used RSK inhibitors, BI-D1870 and SL0101, alter mTORC1 signaling in a RSK-independent manner. Cell Signal. 2015;27:1630-42 pubmed publisher
    The 90 kDa ribosomal S6 kinases (RSK) are effectors of the Ras-ERK1/2 signaling pathway. RSK signaling controls proliferation and protein synthesis, and is altered in several types of tumors...
  56. Jalalirad R, Kavianpour A, Beiroti A, Sepahi M, Tavakoli Zaniani P, Arsalani F. Exploration of Recombinant Streptokinase Degradation Products Under Various pH Reduction Conditions in Downstream Processing. Recent Pat Biotechnol. 2016;9:139-44 pubmed
    ..The aim of this study was to explore the occurrence of rSK degradation during acidification step in downstream processing...
  57. Whittaker R, Hothi H, Eskelinen A, Blunn G, Skinner J, Hart A. Variation in taper surface roughness for a single design effects the wear rate in total hip arthroplasty. J Orthop Res. 2017;35:1784-1792 pubmed publisher
    ..003) and the Skewness (Rsk, the asymmetry of the height distribution corresponding to the height or depth of surface features) (p?=?0.03)...
  58. Graves P, Din S, Ashamalla M, Ashamalla H, Gilbert T, Graves L. Ionizing radiation induces EphA2 S897 phosphorylation in a MEK/ERK/RSK-dependent manner. Int J Radiat Biol. 2017;93:929-936 pubmed publisher
    ..Radiation-induced S897 phosphorylation was unaffected by an AKT inhibitor but blocked by a MEK or RSK inhibitor...
  59. Xing J, Ginty D, Greenberg M. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science. 1996;273:959-63 pubmed
    ..sequencing, and biochemical characterization of CREB kinase revealed that it is identical to a member of the pp90(RSK) family, RSK2...
  60. Janknecht R. Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1). Oncogene. 2003;22:746-55 pubmed
    ..Thus, MSK1 may regulate ER81-dependent transcription via direct phosphorylation of ER81 as well as via stimulation of CBP/p300, which might be important for ER81's normal function and during mammary tumor formation. ..
  61. Xi Y, Niu J, Shen Y, Li D, Peng X, Wu X. AT13148, a first-in-class multi-AGC kinase inhibitor, potently inhibits gastric cancer cells both in vitro and in vivo. Biochem Biophys Res Commun. 2016;478:330-336 pubmed publisher
    ..Akt (at p-Thr-308), p70S6 kinase (p70S6K), glycogen synthase kinase 3β (GSK-3β) and p90 ribosomal S6 kinase (RSK)...
  62. Zhou F, Li M, Wei Y, Lin K, Lu Y, Shen J, et al. Activation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cells. Oncotarget. 2016;7:84093-84117 pubmed publisher
    ..Mechanistically, downregulation of HERV-K blocked expression of tumor-associated genes that included Ras, p-RSK, and p-ERK. The major upstream regulators influenced by HERV-K knockdown were p53, TGF- β1, and MYC...
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    ..and RNA interference revealed a polypharmacology mechanism involving the noncanonical targets IGF1R, FAK1, RSK1 and RSK2. Mutating the downstream signaling hub YB1 protected cells from ceritinib...
  64. Zandi E, Chen Y, Karin M. Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate. Science. 1998;281:1360-3 pubmed
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    ..Tpr (translocated promoter region) as two novel substrates of ERK2, in addition to the known ERK2 substrate Rsk1. To further validate the method, we present data that confirm that ERK2 phosphorylates EDD in vitro and in vivo...
  66. Doehn U, Hauge C, Frank S, Jensen C, Duda K, Nielsen J, et al. RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells. Mol Cell. 2009;35:511-22 pubmed publisher
    ..Many mechanisms by which ERK exerts this control remain elusive. We demonstrate that the ERK-activated kinase RSK is necessary to induce mesenchymal motility and invasive capacities in nontransformed epithelial and carcinoma ..
  67. Zhang X, Lavoie G, Fort L, Huttlin E, Tcherkezian J, Galan J, et al. Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility. Mol Cell Biol. 2013;33:1657-70 pubmed publisher
    ..More specifically, we show that RSK (p90 ribosomal S6 kinase) phosphorylates Gab2 on three conserved residues, both in vivo and in vitro...
  68. Buck M, Poli V, van der Geer P, Chojkier M, Hunter T. Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha. Mol Cell. 1999;4:1087-92 pubmed
    We report that TGF alpha induces activation of the p90 ribosomal S kinase (RSK), which results in the phosphorylation of rat C/EBP beta on Ser-105 and of mouse C/EBP beta on Thr-217 and concomitantly stimulates proliferation in ..
  69. Fluck M, Booth F, Waxham M. Skeletal muscle CaMKII enriches in nuclei and phosphorylates myogenic factor SRF at multiple sites. Biochem Biophys Res Commun. 2000;270:488-94 pubmed
    ..The location of Thr-160 in the 3-D structure of SRF suggests that its phosphorylation by nuclear CaMKII may directly influence DNA binding of SRF and other MADS box factors. ..
  70. Cartlidge R, Knebel A, Peggie M, Alexandrov A, Phizicky E, Cohen P. The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells. EMBO J. 2005;24:1696-705 pubmed
    ..PKB and ribosomal S6 kinase (RSK) both phosphorylated METTL1 at Ser27 in vitro...
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    We showed previously that p90 RSK was activated in cells expressing an activated mutant of MEK5, the activator of the MAP kinase ERK5. Based on the following evidence, we suggest that ERK5 can directly activate RSK in cells...
  72. Kroczynska B, Sharma B, Eklund E, Fish E, Platanias L. Regulatory effects of programmed cell death 4 (PDCD4) protein in interferon (IFN)-stimulated gene expression and generation of type I IFN responses. Mol Cell Biol. 2012;32:2809-22 pubmed publisher
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  73. Smadja Lamère N, Shum M, Déléris P, Roux P, Abe J, Marette A. Insulin activates RSK (p90 ribosomal S6 kinase) to trigger a new negative feedback loop that regulates insulin signaling for glucose metabolism. J Biol Chem. 2013;288:31165-76 pubmed publisher
    ..of RSK using either the pharmacological inhibitor BI-D1870 or after adenoviral expression of a dominant negative RSK1 mutant (RSK1-DN) showed that RSK selectively phosphorylates IRS-1 on Ser-1101...
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    ..Our findings implicate a previously unidentified PPAR?-pERK complex that provides a molecular mechanism for the convergence of these pathways during cognitive enhancement, thereby offering new targets for therapeutic development in AD. ..
  75. Wu M, Hemesath T, Takemoto C, Horstmann M, Wells A, Price E, et al. c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi. Genes Dev. 2000;14:301-12 pubmed
    ..signals derive from MAPK/ERK targeting of serine 73, whereas serine 409 serves as a substrate for p90 Rsk-1...
  76. Pan X, Kane L, Van Eyk J, Coulombe P. Type I keratin 17 protein is phosphorylated on serine 44 by p90 ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion. J Biol Chem. 2011;286:42403-13 pubmed publisher
    ..We show that p90 RSK1, an AGC kinase involved in the regulation of cell survival and proliferation, phosphorylates K17-Ser(44) in skin ..
  77. Sun M, Paciga J, Feldman R, Yuan Z, Coppola D, Lu Y, et al. Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K. Cancer Res. 2001;61:5985-91 pubmed
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    ..GSK-3beta at the (43)Thr residue, which primes GSK-3beta for its subsequent phosphorylation at Ser9 by p90RSK, resulting in inactivation of GSK-3beta and upregulation of beta-catenin...
  79. Koopman R, Pennings B, Zorenc A, van Loon L. Protein ingestion further augments S6K1 phosphorylation in skeletal muscle following resistance type exercise in males. J Nutr. 2007;137:1880-6 pubmed
    ..45 +/- 0.07, P < 0.01) and remained elevated during recovery (P < 0.05). We conclude that the availability of dietary protein further enhances phosphorylation of S6K1 during recovery from resistance type exercise. ..
  80. Clark D, Poteet Smith C, Smith J, Lannigan D. Rsk2 allosterically activates estrogen receptor alpha by docking to the hormone-binding domain. EMBO J. 2001;20:3484-94 pubmed
    ..The allosteric regulation of a target protein, independent of phosphorylation, may be paradigmatic of a general function for protein kinase docking sites. ..
  81. Imai Y, Ohmori K, Yasuda S, Wada M, Suzuki T, Fukuda K, et al. Breast cancer resistance protein/ABCG2 is differentially regulated downstream of extracellular signal-regulated kinase. Cancer Sci. 2009;100:1118-27 pubmed
    ..Inhibition of p90 ribosomal protein S6 kinase (RSK), one of the downstream effectors of ERK, resulted in transcriptional upregulation of endogenous BCRP but did not ..
  82. Chatterjee S, Huang E, Christie I, Kurland B, Burns T. Acquired Resistance to the Hsp90 Inhibitor, Ganetespib, in KRAS-Mutant NSCLC Is Mediated via Reactivation of the ERK-p90RSK-mTOR Signaling Network. Mol Cancer Ther. 2017;16:793-804 pubmed publisher
    ..Genetic or pharmacologic inhibition of p90RSK in ganetespib-resistant cells restored sensitivity to ganetespib, whereas p90RSK overexpression induced ganetespib ..
  83. Wang J, Zhao W, Liu H, He H, Shao R. Myofibrillogenesis regulator 1 (MR-1): a potential therapeutic target for cancer and PNKD. J Drug Target. 2017;:1-6 pubmed publisher
    ..MR-1S directly phosphorylates and activates the MEK-ERK-RSK pathway to accelerate cancer growth and facilitates metastasis by activating the MLC2-FAK-AKT pathway...
  84. Browne G, Proud C. A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin. Mol Cell Biol. 2004;24:2986-97 pubmed
    ..eEF2 kinase is thus a target for mTOR signaling independently of previously known downstream components of the pathway. ..
  85. Taddei P, Tozzi S, Carmignato S, Affatato S. May the surface roughness of the retrieved femoral head influence the wear behavior of the polyethylene liner?. J Biomed Mater Res B Appl Biomater. 2016;104:1374-85 pubmed publisher
    ..showed a higher volumetric loss (as determined by Coordinate Measuring Machine) than the latter, but less negative Rsk values. This apparent lack of correlation between volumetric loss (i.e...
  86. Du K, Montminy M. CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem. 1998;273:32377-9 pubmed
    ..Our results support the notion that Akt/PKB promotes cell survival, at least in part, by stimulating the expression of cellular genes via the CREB/CBP nuclear transduction pathway. ..
  87. Heidenreich O, Neininger A, Schratt G, Zinck R, Cahill M, Engel K, et al. MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo. J Biol Chem. 1999;274:14434-43 pubmed
    Several growth factor- and calcium-regulated kinases such as pp90(rsk) or CaM kinase IV can phosphorylate the transcription factor serum response factor (SRF) at serine 103 (Ser-103)...
  88. Merienne K, Jacquot S, Zeniou M, Pannetier S, Sassone Corsi P, Hanauer A. Activation of RSK by UV-light: phosphorylation dynamics and involvement of the MAPK pathway. Oncogene. 2000;19:4221-9 pubmed
    ..In human, there are three isoforms of RSK (RSK1, RSK2, RSK3), whose functional specificity remains undefined...
  89. McDonald C, Vacratsis P, Bliska J, Dixon J. The yersinia virulence factor YopM forms a novel protein complex with two cellular kinases. J Biol Chem. 2003;278:18514-23 pubmed publisher
    ..Results demonstrate that two kinases, protein kinase C-like 2 (PRK2) and ribosomal S6 protein kinase 1 (RSK1), interact directly with YopM...
  90. Browne G, Finn S, Proud C. Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. J Biol Chem. 2004;279:12220-31 pubmed
    ..Thus, AMPK and eEF2 kinase may provide a key link between cellular energy status and the inhibition of protein synthesis, a major consumer of metabolic energy. ..
  91. Choi Y, Lee S, Aoyagi H, Yamasaki Y, Yoo J, Park B, et al. The extracellular signal-regulated kinase mitogen-activated protein kinase/ribosomal S6 protein kinase 1 cascade phosphorylates cAMP response element-binding protein to induce MUC5B gene expression via D-prostanoid receptor signaling. J Biol Chem. 2011;286:34199-214 pubmed publisher
    ..Proximity ligation assays showed direct interaction between RSK1 and cAMP response element-binding protein (CREB)...
  92. Im J, Kim B, Lee J, Park S, Ban H, Jung K, et al. DDIAS suppresses TRAIL-mediated apoptosis by inhibiting DISC formation and destabilizing caspase-8 in cancer cells. Oncogene. 2018;37:1251-1262 pubmed publisher
    ..DDIAS knockdown also suppressed epidermal growth factor-induced phosphorylation of p90 ribosomal S6 kinase (RSK) 2 and stabilized caspase-8 by preventing its ubiquitination and proteasomal degradation...
  93. Li P, Goto H, Kasahara K, Matsuyama M, Wang Z, Yatabe Y, et al. P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation. Mol Biol Cell. 2012;23:1582-92 pubmed publisher
    ..On the other hand, the Ras/mitogen-activated protein kinase/90-kDa ribosomal S6 kinase (p90 RSK) pathway is a central node in cell signaling downstream of growth factors...
  94. Cho J, Kim S, Seo Y, Park S, Park B, Kim J, et al. The p90 ribosomal S6 kinase-UBR5 pathway controls Toll-like receptor signaling via miRNA-induced translational inhibition of tumor necrosis factor receptor-associated factor 3. J Biol Chem. 2017;292:11804-11814 pubmed publisher
    ..We further demonstrated that p90 ribosomal S6 kinase (p90RSK) is an upstream regulator of UBR5...
  95. Li M, Radvanyi L, Yin B, Li J, Chivukula R, Lin K, et al. Downregulation of Human Endogenous Retrovirus Type K (HERV-K) Viral env RNA in Pancreatic Cancer Cells Decreases Cell Proliferation and Tumor Growth. Clin Cancer Res. 2017;23:5892-5911 pubmed publisher
    ..downregulation of HERV-K Env protein expression by shRNA also resulted in decreased expression of RAS, p-ERK, p-RSK, and p-AKT in several pancreatic cancer cells or tumors...
  96. Alexa A, Gógl G, Glatz G, Garai Ã, Zeke A, Varga J, et al. Structural assembly of the signaling competent ERK2-RSK1 heterodimeric protein kinase complex. Proc Natl Acad Sci U S A. 2015;112:2711-6 pubmed publisher
    ..Notably, extracellular signal regulated kinase 2 (ERK2) phosphorylates ribosomal S6 kinase 1 (RSK1), which promotes cellular growth...
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    ..Reverse phase protein array (RPPA) analysis showed that NHE1 expression positively correlated with p90RSK expression in basal, but not luminal, primary tumours...
  98. Nakajima T, Fukamizu A, Takahashi J, Gage F, Fisher T, Blenis J, et al. The signal-dependent coactivator CBP is a nuclear target for pp90RSK. Cell. 1996;86:465-74 pubmed
    ..These results provide a demonstration of cross-coupling between two signaling pathways that occurs at the level of a signal-dependent coactivator. ..
  99. Zaheer A, Lim R. Protein kinase A (PKA)- and protein kinase C-phosphorylated glia maturation factor promotes the catalytic activity of PKA. J Biol Chem. 1997;272:5183-6 pubmed
    ..The generation of various phospho-isoforms of GMF may explain its modulation of signal transduction at multiple locations. ..
  100. Couñago R, Allerston C, Savitsky P, Azevedo H, Godoi P, Wells C, et al. Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations. Sci Rep. 2017;7:7501 pubmed publisher
    ..Here we identified BI-D1870, a dihydropteridine inhibitor of RSK kinases, as a promising starting point for the development of chemical probes targeting the active VRKs...
  101. del Peso L, Gonzalez Garcia M, Page C, Herrera R, Nunez G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science. 1997;278:687-9 pubmed
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