p73

Summary

Gene Symbol: p73
Description: tumor protein p73
Alias: P73, tumor protein p73, p53-like transcription factor, p53-related protein
Species: human
Products:     p73

Top Publications

  1. Bergamaschi D, Samuels Y, Jin B, Duraisingham S, Crook T, Lu X. ASPP1 and ASPP2: common activators of p53 family members. Mol Cell Biol. 2004;24:1341-50 pubmed
    ..We show here that ASPP1 and ASPP2 also induce apoptosis independently of p53. By binding to p63 and p73 in vitro and in vivo, ASPP1 and ASPP2 stimulate the transactivation function of p63 and p73 on the promoters of Bax,..
  2. Faridoni Laurens L, Tourpin S, Alsafadi S, Barrois M, Temam S, Janot F, et al. Involvement of N-terminally truncated variants of p73, deltaTAp73, in head and neck squamous cell cancer: a comparison with p53 mutations. Cell Cycle. 2008;7:1587-96 pubmed
    b>p73, a p53-related gene, encodes two classes of isoforms with opposing functions: (1) a full-length transactivation-competent p73 protein (TAp73) with tumour suppressor activity; and (2) a group of NH2-terminally truncated, ..
  3. Ren J, Datta R, Shioya H, Li Y, Oki E, Biedermann V, et al. p73beta is regulated by protein kinase Cdelta catalytic fragment generated in the apoptotic response to DNA damage. J Biol Chem. 2002;277:33758-65 pubmed
    ..These findings demonstrate that cleavage of PKCdelta to PKCdeltaCF induces apoptosis by a mechanism in part dependent on PKCdeltaCF-mediated phosphorylation of the p73beta Ser-289 site. ..
  4. Vilgelm A, Hong S, Washington M, Wei J, Chen H, el Rifai W, et al. Characterization of ?Np73 expression and regulation in gastric and esophageal tumors. Oncogene. 2010;29:5861-8 pubmed publisher
    b>p73 is a member of the p53 protein family. Although the tumor suppressor function of p53 is clearly defined, the role of p73 in tumorigenesis is still a matter of debate...
  5. Al Bahlani S, Fraser M, Wong A, Sayan B, Bergeron R, Melino G, et al. P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism. Oncogene. 2011;30:4219-30 pubmed publisher
    b>P73 is important in drug-induced apoptosis in some cancer cells, yet its role in the regulation of chemosensitivity in ovarian cancer (OVCA) is poorly understood...
  6. Marrazzo E, Marchini S, Previdi S, Broggini M. Questioning the oncogenic role of DeltaNp73alpha in different cell lines expressing p53 or not. Cancer Biol Ther. 2006;5:794-803 pubmed
    The recent finding that the 1p36.3 locus gene encodes an array of different p73 isoforms with apparently distinct and sometimes opposing cellular functions, might explain the difficulty in establishing the protein's role as tumor ..
  7. Nyman U, Sobczak Pluta A, Vlachos P, Perlmann T, Zhivotovsky B, Joseph B. Full-length p73alpha represses drug-induced apoptosis in small cell lung carcinoma cells. J Biol Chem. 2005;280:34159-69 pubmed
    The p73 gene, a member of the p53 family, encodes several variants through differential splicing and use of alternative promoters...
  8. DeYoung M, Johannessen C, Leong C, Faquin W, Rocco J, Ellisen L. Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinoma. Cancer Res. 2006;66:9362-8 pubmed
    ..epithelial cells, and that dependence is mediated through tumor-specific up-regulation of the related protein p73. In normal primary human keratinocytes, we find that inhibition of endogenous p63 by RNA interference (RNAi) ..
  9. Stiewe T, Tuve S, Peter M, Tannapfel A, Elmaagacli A, Pützer B. Quantitative TP73 transcript analysis in hepatocellular carcinomas. Clin Cancer Res. 2004;10:626-33 pubmed
    The p53 family member p73 displays significant homology to p53, but data from primary tumors demonstrating increased expression levels of p73 in the absence of any gene mutations argue against a classical tumor suppressor function...

More Information

Publications145 found, 100 shown here

  1. Goldschneider D, Million K, Meiller A, Haddada H, Puisieux A, Benard J, et al. The neurogene BTG2TIS21/PC3 is transactivated by DeltaNp73alpha via p53 specifically in neuroblastoma cells. J Cell Sci. 2005;118:1245-53 pubmed
    The p53 gene and its homologue p73 are rarely mutated in neuroblastoma...
  2. Holcakova J, Ceskova P, Hrstka R, Muller P, Dubska L, Coates P, et al. The cell type-specific effect of TAp73 isoforms on the cell cycle and apoptosis. Cell Mol Biol Lett. 2008;13:404-20 pubmed publisher
    b>p73, a member of the p53 family, exhibits activities similar to those of p53, including the ability to induce growth arrest and apoptosis. p73 influences chemotherapeutic responses in human cancer patients, in association with p53...
  3. Grande L, Bretones G, Rosa Garrido M, Garrido Martin E, Hernandez T, Fraile S, et al. Transcription factors Sp1 and p73 control the expression of the proapoptotic protein NOXA in the response of testicular embryonal carcinoma cells to cisplatin. J Biol Chem. 2012;287:26495-505 pubmed publisher
    ..A detailed analysis of the Noxa promoter revealed that p73 and Sp1-like factors, Sp1 and KLF6, played key roles in the transcriptional control of this gene...
  4. Killick R, Niklison Chirou M, Tomasini R, Bano D, Rufini A, Grespi F, et al. p73: a multifunctional protein in neurobiology. Mol Neurobiol. 2011;43:139-46 pubmed publisher
    b>p73, a transcription factor of the p53 family, plays a key role in many biological processes including neuronal development...
  5. Yan W, Zhang J, Zhang Y, Jung Y, Chen X. p73 expression is regulated by RNPC1, a target of the p53 family, via mRNA stability. Mol Cell Biol. 2012;32:2336-48 pubmed publisher
    b>p73, a p53 family tumor suppressor, is expressed as TA and ?N isoforms...
  6. Sayan A, Sayan B, Gogvadze V, Dinsdale D, Nyman U, Hansen T, et al. P73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis. Oncogene. 2008;27:4363-72 pubmed publisher
    The p73 protein, a member of the p53 family, has both developmental and tumorigenic functions...
  7. Toh W, Kyo S, Sabapathy K. Relief of p53-mediated telomerase suppression by p73. J Biol Chem. 2005;280:17329-38 pubmed
    ..Here we have evaluated the role of p73 in hTERT regulation...
  8. Schmelz K, Wagner M, Dorken B, Tamm I. 5-Aza-2'-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia. Int J Cancer. 2005;114:683-95 pubmed
    ..of its promoter methylation status but mediated by 5-Aza-CdR-induced reexpression of the tumor-suppressor p73, a known upstream regulator of p21...
  9. Vilgelm A, Wei J, Piazuelo M, Washington M, Prassolov V, el Rifai W, et al. DeltaNp73alpha regulates MDR1 expression by inhibiting p53 function. Oncogene. 2008;27:2170-6 pubmed
    The p73 protein is a transcription factor and member of the p53 protein family that expresses as a complex variety of isoforms. DeltaNp73alpha is an N-terminally truncated isoform of p73...
  10. Mattson M, Ashery U. No more brain tangles with DeltaNp73. Trends Biochem Sci. 2009;34:6-8 pubmed publisher
    ..A new study reveals a surprising neuroprotective role for a truncated p73 isoform (DeltaNp73)...
  11. Castellino R, De Bortoli M, Lin L, Skapura D, Rajan J, Adesina A, et al. Overexpressed TP73 induces apoptosis in medulloblastoma. BMC Cancer. 2007;7:127 pubmed
    ..These results indicate that primary medulloblastomas express significant levels of TP73 isoforms, and suggest that they can modulate the survival and genotoxic responsiveness of medulloblastomas cells. ..
  12. Kikuchi H, Ozaki T, Furuya K, Hanamoto T, Nakanishi M, Yamamoto H, et al. NF-kappaB regulates the stability and activity of p73 by inducing its proteolytic degradation through a ubiquitin-dependent proteasome pathway. Oncogene. 2006;25:7608-17 pubmed
    ..Taken together, our present results imply that NF-kappaB-mediated degradation of proapoptotic p73 is a novel inhibitory mechanism of p73 that regulates cell survival and death.
  13. Bernassola F, Salomoni P, Oberst A, Di Como C, Pagano M, Melino G, et al. Ubiquitin-dependent degradation of p73 is inhibited by PML. J Exp Med. 2004;199:1545-57 pubmed
    b>p73 has been identified recently as a structural and functional homologue of the tumor suppressor p53. Here, we report that p73 stability is directly regulated by the ubiquitin-proteasome pathway...
  14. Ibrahim N, He L, Leong C, Xing D, Karlan B, Swisher E, et al. BRCA1-associated epigenetic regulation of p73 mediates an effector pathway for chemosensitivity in ovarian carcinoma. Cancer Res. 2010;70:7155-65 pubmed publisher
    ..Here, we show that the p53-related gene p73, encoding a proapoptotic protein that is linked to chemosensitivity in many settings, is upregulated through a ..
  15. Prieto Remón I, Sánchez Carrera D, López Duarte M, Richard C, Pipaon C. BIK (NBK) is a mediator of the sensitivity of Fanconi anaemia group C lymphoblastoid cell lines to interstrand DNA cross-linking agents. Biochem J. 2012;448:153-63 pubmed publisher
    ..evidence of a previously undescribed indirect epigenetic regulation of BIK in FA-C lymphoblasts mediated by ?Np73, an isoform of p73 lacking its transactivation domain that activates BIK through a proximal element in its promoter.
  16. Lee K, Hong Y, Kim B, Kim N, Lee K, Kwak J, et al. p73 G4C14 to A4T14 polymorphism is associated with colorectal cancer risk and survival. World J Gastroenterol. 2010;16:4448-54 pubmed
    To analyze the association between the p73 G4C14-to-A4T14 polymorphism (a.k.a...
  17. Ugur H, Sayan A, Ozdamar S, Kanpolat Y, Ozturk M. Expression of TAP73 and DeltaNP73 in malignant gliomas. Oncol Rep. 2004;11:1337-41 pubmed
    The p73 gene is able to encode transcriptionaly active TAp73, as well as a dominant-negatively acting DeltaNp73 transcript isoforms...
  18. Marqués García F, Ferrandiz N, Fernández Alonso R, González Cano L, Herreros Villanueva M, Rosa Garrido M, et al. p73 plays a role in erythroid differentiation through GATA1 induction. J Biol Chem. 2009;284:21139-56 pubmed publisher
    The TP73 gene gives rise to transactivation domain-p73 isoforms (TAp73) as well as DeltaNp73 variants with a truncated N terminus...
  19. Katayama H, Wang J, Treekitkarnmongkol W, Kawai H, Sasai K, Zhang H, et al. Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73. Cancer Cell. 2012;21:196-211 pubmed publisher
    ..We report that Aurora-A phosphorylation of p73 at serine235 abrogates its transactivation function and causes cytoplasmic sequestration in a complex with the ..
  20. Lee A, Ho D, Zanassi P, Walsh G, Kaplan D, Miller F. Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms. J Neurosci. 2004;24:9174-84 pubmed
    The p53 family member, p73, is essential for the survival of sympathetic neurons during the developmental period of naturally occurring neuronal death...
  21. Joerger A, Rajagopalan S, Natan E, Veprintsev D, Robinson C, Fersht A. Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Proc Natl Acad Sci U S A. 2009;106:17705-10 pubmed publisher
    Oligomerization of members of the p53 family of transcription factors (p53, p63, and p73) is essential for their distinct functions in cell-cycle control and development...
  22. Rocco J, Leong C, Kuperwasser N, DeYoung M, Ellisen L. p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis. Cancer Cell. 2006;9:45-56 pubmed
    ..is an essential survival factor in head and neck squamous cell carcinoma (HNSCC) through its ability to suppress p73-dependent apoptosis...
  23. Schabath M, Wu X, Wei Q, Li G, Gu J, Spitz M. Combined effects of the p53 and p73 polymorphisms on lung cancer risk. Cancer Epidemiol Biomarkers Prev. 2006;15:158-61 pubmed
    ..Polymorphisms in members of the p53 family, such as p53 and p73, that have a functional relevance would be predicted to contribute to the disease phenotype...
  24. Leupin N, Lüthi A, Novak U, Grob T, Hugli B, Graber H, et al. P73 status in B-cell chronic lymphocytic leukaemia. Leuk Lymphoma. 2004;45:1205-7 pubmed
    ..The p73 gene (a p53 homologue) encodes 2 proteins with opposing functions...
  25. Candi E, Agostini M, Melino G, Bernassola F. How the TP53 family proteins TP63 and TP73 contribute to tumorigenesis: regulators and effectors. Hum Mutat. 2014;35:702-14 pubmed publisher
    In mammals, the p53 family comprises two additional members, p63 and p73 (hereafter referred to as TP53, TP63, and TP73, respectively)...
  26. Rossi M, De Laurenzi V, Munarriz E, Green D, Liu Y, Vousden K, et al. The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J. 2005;24:836-48 pubmed
    b>p73, a member of the p53 family of transcription factors, is upregulated in response to DNA damage, inducing cell cycle arrest and apoptosis...
  27. Fernandez Garcia B, Vaqué J, Herreros Villanueva M, Marques Garcia F, Castrillo F, Fernandez Medarde A, et al. p73 cooperates with Ras in the activation of MAP kinase signaling cascade. Cell Death Differ. 2007;14:254-65 pubmed
    The p73 gene is capable of inducing cell cycle arrest, apoptosis, senescence, differentiation and to cooperate with oncogenic Ras in cellular transformation...
  28. Vayssade M, Haddada H, Faridoni Laurens L, Tourpin S, Valent A, Benard J, et al. P73 functionally replaces p53 in Adriamycin-treated, p53-deficient breast cancer cells. Int J Cancer. 2005;116:860-9 pubmed
    p53-Related genes, p73 and p63, encode 2 classes of proteins, TA-p73/p63 and DeltaN-p73/p63...
  29. Amelio I, Markert E, Rufini A, Antonov A, Sayan B, Tucci P, et al. p73 regulates serine biosynthesis in cancer. Oncogene. 2014;33:5039-46 pubmed publisher
    ..In human lung adenocarcinomas we identified a correlation between serine biosynthetic pathway and p73 expression...
  30. Liu G, Nozell S, Xiao H, Chen X. DeltaNp73beta is active in transactivation and growth suppression. Mol Cell Biol. 2004;24:487-501 pubmed
    b>p73, a p53 family protein, shares significant sequence homolog and functional similarity with p53. However, unlike p53, p73 has at least seven alternatively spliced isoforms with different carboxyl termini (p73alpha-eta)...
  31. Cui R, Nguyen T, Taube J, Stratton S, Feuerman M, Barton M. Family members p53 and p73 act together in chromatin modification and direct repression of alpha-fetoprotein transcription. J Biol Chem. 2005;280:39152-60 pubmed
    ..We find that AFP gene expression is repressed by the TP53 family member p73 during normal hepatic development and when p73alpha or p73beta is introduced into cultured hepatoma cells that ..
  32. Bell H, Dufes C, O Prey J, Crighton D, Bergamaschi D, Lu X, et al. A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo. J Clin Invest. 2007;117:1008-18 pubmed
    ..p53 family members, in particular p73, are in many ways functional paralogs of p53, but are rarely mutated in cancer...
  33. Pediconi N, Ianari A, Costanzo A, Belloni L, Gallo R, Cimino L, et al. Differential regulation of E2F1 apoptotic target genes in response to DNA damage. Nat Cell Biol. 2003;5:552-8 pubmed
    ..at the transcriptional level by E2F1 overexpression, including the genes encoding INK4a/ARF, Apaf-1, caspase 7 and p73 (refs 3-5)...
  34. Marabese M, Vikhanskaya F, Broggini M. p73: a chiaroscuro gene in cancer. Eur J Cancer. 2007;43:1361-72 pubmed
    b>p73 is a member of the p53 family which is gaining increasing importance in the field of cancer. Its structural homology with p53 led to the assumption that it could act as a new tumour suppressor gene...
  35. Robinson R, Lu X, Jones E, Siebold C. Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73. Structure. 2008;16:259-68 pubmed publisher
    ..binding for C-terminal domains of iASPP and ASPP2 to the core domains of p53 family members p53, p63, and p73. We also determined a high-resolution crystal structure for the C terminus of iASPP, comprised of four ankyrin ..
  36. Peschiaroli A, Scialpi F, Bernassola F, Pagano M, Melino G. The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73. Oncogene. 2009;28:3157-66 pubmed publisher
    The transcription factor p73, a member of the p53 family, mediates cell-cycle arrest and apoptosis in response to DNA damage-induced cellular stress, acting thus as a proapoptotic gene...
  37. Burge S, Teufel D, Townsley F, Freund S, Bycroft M, Fersht A. Molecular basis of the interactions between the p73 N terminus and p300: effects on transactivation and modulation by phosphorylation. Proc Natl Acad Sci U S A. 2009;106:3142-7 pubmed publisher
    The transcription factor p73 belongs to the p53 family of proteins and can transactivate a number of target genes in common with p53...
  38. Sznarkowska A, Maleńczyk K, Kadziński L, Bielawski K, Banecki B, Zawacka Pankau J. Targeting of p53 and its homolog p73 by protoporphyrin IX. FEBS Lett. 2011;585:255-60 pubmed publisher
    ..addressed the induction of apoptosis in HCT 116 p53-null cells by PpIX and revealed interactions between PpIX and p73. We propose that PpIX disrupts the p53/MDM2 or MDMX and p73/MDM2 complexes and thereby activates the p53- or p73-..
  39. Vossio S, Palescandolo E, Pediconi N, Moretti F, Balsano C, Levrero M, et al. DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest. Oncogene. 2002;21:3796-803 pubmed
    p53 and p73 genes are both activated in response to DNA damage to induce either cell cycle arrest or apoptosis, depending on the strength and the quality of the damaging stimulus...
  40. Melino G, De Laurenzi V, Vousden K. p73: Friend or foe in tumorigenesis. Nat Rev Cancer. 2002;2:605-15 pubmed
  41. Ben Yehoyada M, Ben Dor I, Shaul Y. c-Abl tyrosine kinase selectively regulates p73 nuclear matrix association. J Biol Chem. 2003;278:34475-82 pubmed
    b>p73 is a structural and functional homologue of the p53 tumor-suppressor protein. Like p53, p73 is activated in response to DNA-damaging insults to induce cell cycle arrest or apoptosis...
  42. Nyman U, Vlachos P, Cascante A, Hermanson O, Zhivotovsky B, Joseph B. Protein kinase C-dependent phosphorylation regulates the cell cycle-inhibitory function of the p73 carboxy terminus transactivation domain. Mol Cell Biol. 2009;29:1814-25 pubmed publisher
    The transcription factor p73, a member of the p53 family of proteins, is involved in the regulation of cell cycle progression and apoptosis...
  43. De Feo E, Persiani R, La Greca A, Amore R, Arzani D, Rausei S, et al. A case-control study on the effect of p53 and p73 gene polymorphisms on gastric cancer risk and progression. Mutat Res. 2009;675:60-5 pubmed publisher
    The p53 protein and its functional homologue p73 share several functions in modulating cell-cycle control and apoptosis...
  44. Zaika E, Wei J, Yin D, Andl C, Moll U, El Rifai W, et al. p73 protein regulates DNA damage repair. FASEB J. 2011;25:4406-14 pubmed publisher
    ..is relatively well characterized, much less is known about the functions of other members of the p53 family, p73 and p63...
  45. Kommagani R, Payal V, Kadakia M. Differential regulation of vitamin D receptor (VDR) by the p53 Family: p73-dependent induction of VDR upon DNA damage. J Biol Chem. 2007;282:29847-54 pubmed
    p63 and p73, members of the p53 family, have been shown to be functionally distinct from p53...
  46. Scacchi R, Gambina G, Moretto G, Corbo R. Association study between P53 and P73 gene polymorphisms and the sporadic late-onset form of Alzheimer's disease. J Neural Transm (Vienna). 2009;116:1179-84 pubmed publisher
    ..Two members of the same protein family that regulates many genes involved in apoptosis are P53 and the heterologue P73. One single nucleotide polymorphism (SNP) in the gene encoding P53 (Arg72Pro, RS1042522), one dinucleotide ..
  47. Muppani N, Nyman U, Joseph B. TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death. Oncotarget. 2011;2:1145-54 pubmed
    ..In conclusion, the ability of TAp73alpha to act as an inhibitor of caspase-2-induced cell death together with its up-regulation in certain tumour types strengthen the potential oncogenic activities for this protein. ..
  48. Gonzalez Cano L, Hillje A, Fuertes Alvarez S, Marques M, Blanch A, Ian R, et al. Regulatory feedback loop between TP73 and TRIM32. Cell Death Dis. 2013;4:e704 pubmed publisher
    The p73 transcription factor is one of the members of the p53 family of tumor suppressors with unique biological functions in processes like neurogenesis, embryonic development and differentiation...
  49. Toh W, Nam S, Sabapathy K. An essential role for p73 in regulating mitotic cell death. Cell Death Differ. 2010;17:787-800 pubmed publisher
    ..The molecular mechanisms regulating cell death during mitosis are poorly understood. We show here a critical role for p73, but not p53, in regulating mitotic cell death induced by various means...
  50. Graupner V, Alexander E, Overkamp T, Rothfuss O, De Laurenzi V, Gillissen B, et al. Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level. Cell Death Differ. 2011;18:1130-9 pubmed publisher
    ..Interestingly, Bak expression can also be induced by p73 that binds however to each of the three p53-binding sites within the bak promoter region...
  51. Stiewe T, Stanelle J, Theseling C, Pollmeier B, Beitzinger M, Pützer B. Inactivation of retinoblastoma (RB) tumor suppressor by oncogenic isoforms of the p53 family member p73. J Biol Chem. 2003;278:14230-6 pubmed
    ..Whereas p53 displays all characteristics of a classical tumor suppressor, its homologues p63 and p73 do not...
  52. Watson I, Blanch A, Lin D, Ohh M, Irwin M. Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function. J Biol Chem. 2006;281:34096-103 pubmed
    Mutations in p73 are rare in cancer. Emerging evidence suggests that the relative expression of various p73 isoforms may contribute to tumorigenesis...
  53. Li G, Sturgis E, Wang L, Chamberlain R, Amos C, Spitz M, et al. Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of squamous cell carcinoma of the head and neck. Carcinogenesis. 2004;25:1911-6 pubmed
    b>p73, a novel p53 homolog, has some p53-like activity and plays an important role in modulating cell-cycle control, apoptosis and cell growth...
  54. Liu S, Chan K, Cheung A, Liao X, Leung T, Ngan H. Expression of deltaNp73 and TAp73alpha independently associated with radiosensitivities and prognoses in cervical squamous cell carcinoma. Clin Cancer Res. 2006;12:3922-7 pubmed
    The p73 gene produces different protein isoforms using alternative promoters and splicing, which have different biological characteristics...
  55. Mukerjee R, Deshmane S, Fan S, Del Valle L, White M, Khalili K, et al. Involvement of the p53 and p73 transcription factors in neuroAIDS. Cell Cycle. 2008;7:2682-90 pubmed
    ..We have now examined the ability of Tat to activate the p53 pathway leading to the induction of endogenous p53 and p73 in neuronal cells...
  56. Hatzimichael E, Benetatos L, Dasoula A, Dranitsaris G, Tsiara S, Georgiou I, et al. Absence of methylation-dependent transcriptional silencing in TP73 irrespective of the methylation status of the CDKN2A CpG island in plasma cell neoplasia. Leuk Res. 2009;33:1272-5 pubmed publisher
    ..Further evaluation in a larger sample of patients is needed in order to enhance our statistical power and to test our hypothesis that CDKN2A methylation status can become a useful prognostic biomarker. ..
  57. Rödicker F, Pützer B. p73 is effective in p53-null pancreatic cancer cells resistant to wild-type TP53 gene replacement. Cancer Res. 2003;63:2737-41 pubmed
    ..Here we show that adenovirus-mediated p73 overexpression results in a strong induction of apoptosis, whereas the effect of p53 varies between different cell ..
  58. Melino G, Bernassola F, Ranalli M, Yee K, Zong W, Corazzari M, et al. p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J Biol Chem. 2004;279:8076-83 pubmed
    b>p73, an important developmental gene, shares a high sequence homology with p53 and induces both G(1) cell cycle arrest and apoptosis. However, the molecular mechanisms through which p73 induces apoptosis are unclear...
  59. Levy D, Adamovich Y, Reuven N, Shaul Y. The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73. Cell Death Differ. 2007;14:743-51 pubmed
    Upon DNA damage signaling, p73, a member of the p53 tumor suppressor family, accumulates to support transcription of downstream apoptotic genes...
  60. Tsai K, Yuan Z. c-Abl stabilizes p73 by a phosphorylation-augmented interaction. Cancer Res. 2003;63:3418-24 pubmed
    The proapoptotic function of c-Abl is in part mediated by its functional interaction with p73, a p53 homologue...
  61. Buhlmann S, Racek T, Schwarz A, Schaefer S, Pützer B. Molecular mechanism of p73-mediated regulation of hepatitis B virus core promoter/enhancer II: implications for hepatocarcinogenesis. J Mol Biol. 2008;378:20-30 pubmed publisher
    ..Recent findings demonstrating p73 and specifically N-terminally truncated p73 (DeltaTAp73) accumulation in hepatocellular carcinoma suggest that p73 ..
  62. Chen X, Sturgis E, El Naggar A, Wei Q, Li G. Combined effects of the p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms on the risk of HPV16-associated oral cancer in never-smokers. Carcinogenesis. 2008;29:2120-5 pubmed publisher
    Because p53 and p73 are associated with critical cellular processes and can be inactivated or degraded by the human papillomavirus (HPV) E6 oncoprotein, we investigated the combined effects of p53 codon 72 and p73 G4C14-to-A4T14 ..
  63. Seelan R, Irwin M, van der Stoop P, Qian C, Kaelin W, Liu W. The human p73 promoter: characterization and identification of functional E2F binding sites. Neoplasia. 2002;4:195-203 pubmed
    b>p73, a member of the p53 family, is overexpressed in many cancers. To understand the mechanism(s) underlying this overexpression, we have undertaken a detailed characterization of the human p73 promoter...
  64. Li Q, Athan E, Wei M, Yuan E, Rice S, Vonsattel J, et al. TP73 allelic expression in human brain and allele frequencies in Alzheimer's disease. BMC Med Genet. 2004;5:14 pubmed
    The p73 protein, a paralogue of the p53 tumor suppressor, is essential for normal development and survival of neurons. TP73 is therefore of interest as a candidate gene for Alzheimer's disease (AD) susceptibility...
  65. Strano S, Monti O, Pediconi N, Baccarini A, Fontemaggi G, Lapi E, et al. The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage. Mol Cell. 2005;18:447-59 pubmed
    The transcriptional coactivator Yes-associated protein (YAP) has been shown to interact with and to enhance p73-dependent apoptosis in response to DNA damage...
  66. Guglielmino M, Santonocito M, Vento M, Ragusa M, Barbagallo D, Borzì P, et al. TAp73 is downregulated in oocytes from women of advanced reproductive age. Cell Cycle. 2011;10:3253-6 pubmed publisher
    ..In order to verify the potential involvement of p73 in reproductive aging, we determined its expression in single mature MII oocytes from two groups of women, younger ..
  67. Dobbelstein M, Strano S, Roth J, Blandino G. p73-induced apoptosis: a question of compartments and cooperation. Biochem Biophys Res Commun. 2005;331:688-93 pubmed
    The transcriptionally active forms of p73 are capable of inducing apoptosis, and the isoforms termed TAp73 are important players when E2F and its oncogenic activators induce programmed cell death...
  68. Zitterbart K, Zavrelova I, Kadlecova J, Spesna R, Kratochvilova A, Pavelka Z, et al. p73 expression in medulloblastoma: TAp73/DeltaNp73 transcript detection and possible association of p73alpha/DeltaNp73 immunoreactivity with survival. Acta Neuropathol. 2007;114:641-50 pubmed
    The human p73 protein is essential for normal morphogenesis and maintenance of neural tissue. Recently, several TP73 transcripts have been revealed in medulloblastoma (MB), the most common malignant brain tumor in children...
  69. Kommagani R, Whitlatch A, Leonard M, Kadakia M. p73 is essential for vitamin D-mediated osteoblastic differentiation. Cell Death Differ. 2010;17:398-407 pubmed publisher
    ..In this study, we show that p73 acts as an upstream regulator of VD3-mediated osteoblastic differentiation...
  70. Munarriz E, Barcaroli D, Stephanou A, Townsend P, Maisse C, Terrinoni A, et al. PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73. Mol Cell Biol. 2004;24:10593-610 pubmed
    b>p73 is a recently described member of the p53 family, and, like p53, it undergoes a number of posttranslational modifications...
  71. Murray Zmijewski F, Lane D, Bourdon J. p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress. Cell Death Differ. 2006;13:962-72 pubmed
    p63, p73 and p53 compose a family of transcription factors involved in cell response to stress and development...
  72. Brigati C, Banelli B, Casciano I, di Vinci A, Matis S, Cutrona G, et al. Epigenetic mechanisms regulate ?NP73 promoter function in human tonsil B cells. Mol Immunol. 2011;48:408-14 pubmed publisher
    ..Our results suggest a ?Np73 function in B cell immunity, indicate epigenetics as master TP73 P2 regulator, and point to AP1 site occupancy as playing an putative mechanistic role in this process. ..
  73. Ohtsuka T, Ryu H, Minamishima Y, Ryo A, Lee S. Modulation of p53 and p73 levels by cyclin G: implication of a negative feedback regulation. Oncogene. 2003;22:1678-87 pubmed
    ..Here, we show a negative effect of cyclin G on the stability of p53 and p73. Cyclin G expression resulted in a dramatic decrease of p53 protein levels in response to DNA damage and abrogated ..
  74. Feng Z, Zhang C, Kang H, Sun Y, Wang H, Naqvi A, et al. Regulation of female reproduction by p53 and its family members. FASEB J. 2011;25:2245-55 pubmed publisher
    ..Studies with p63- and p73-knockout mice have demonstrated the involvement of p63 and p73 in female reproduction and their roles in egg ..
  75. Hosoda M, Ozaki T, Miyazaki K, Hayashi S, Furuya K, Watanabe K, et al. UFD2a mediates the proteasomal turnover of p73 without promoting p73 ubiquitination. Oncogene. 2005;24:7156-69 pubmed
    b>p73 protein level is kept extremely low in mammalian cultured cells and its stability may be regulated by not only the ubiquitin/proteasome-dependent proteolysis but also through other unidentified mechanisms...
  76. Logotheti S, Michalopoulos I, Sideridou M, Daskalos A, Kossida S, Spandidos D, et al. Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73gamma in lung cancer. FEBS J. 2010;277:3014-27 pubmed publisher
    The p73 gene possesses an extrinsic P1 promoter and an intrinsic P2 promoter, resulting in TAp73 and DeltaNup73 isoforms, respectively...
  77. Daskalos A, Logotheti S, Markopoulou S, Xinarianos G, Gosney J, Kastania A, et al. Global DNA hypomethylation-induced ?Np73 transcriptional activation in non-small cell lung cancer. Cancer Lett. 2011;300:79-86 pubmed publisher
    b>p73 possesses an extrinsic P1 promoter and an intrinsic P2 promoter controlling the expression of the pro-apoptotic TAp73 isoforms and the anti-apoptotic ??p73 isoforms respectively...
  78. Tuve S, Wagner S, Schittek B, Pützer B. Alterations of DeltaTA-p 73 splice transcripts during melanoma development and progression. Int J Cancer. 2004;108:162-6 pubmed
    In the last 2 years, it has become apparent that the p53-family members p53 and p73 play fundamentally different roles in human malignancies...
  79. Mantovani F, Piazza S, Gostissa M, Strano S, Zacchi P, Mantovani R, et al. Pin1 links the activities of c-Abl and p300 in regulating p73 function. Mol Cell. 2004;14:625-36 pubmed
    Activation of p73 upon genotoxic treatment triggers apoptosis of tumor cells lacking functional p53 and involves the activities of c-Abl and p300...
  80. Rossi M, Sayan A, Terrinoni A, Melino G, Knight R. Mechanism of induction of apoptosis by p73 and its relevance to neuroblastoma biology. Ann N Y Acad Sci. 2004;1028:143-9 pubmed
    ..However, TP73 harbors an additional promoter that produces a dominant negative p73 protein (deltaNp73) having the opposite effect of the TAp73 protein...
  81. Liu G, Chen X. The C-terminal sterile alpha motif and the extreme C terminus regulate the transcriptional activity of the alpha isoform of p73. J Biol Chem. 2005;280:20111-9 pubmed
    b>p73, a member of the p53 family, is expressed from two separate promoters, generating TA and DeltaN variants. Each variant potentially encodes at least seven alternatively spliced isoforms (alpha-eta)...
  82. Ramadan S, Terrinoni A, Catani M, Sayan A, Knight R, Mueller M, et al. p73 induces apoptosis by different mechanisms. Biochem Biophys Res Commun. 2005;331:713-7 pubmed
    b>p73, like its homologue, the tumor suppressor p53, is able to induce apoptosis in several cell types. This property is important for the involvement of p73 in cancer development and therapy...
  83. Marabese M, Marchini S, Sabatino M, Polato F, Vikhanskaya F, Marrazzo E, et al. Effects of inducible overexpression of DNp73alpha on cancer cell growth and response to treatment in vitro and in vivo. Cell Death Differ. 2005;12:805-14 pubmed
    The p73 gene has a complex regulation, which leads to the expression of different isoforms, often with opposite biological effects...
  84. Wang J, Liu Y, Hande M, Wong A, Jin Y, Yin Y. TAp73 is a downstream target of p53 in controlling the cellular defense against stress. J Biol Chem. 2007;282:29152-62 pubmed
    ..Our data reveal a new pathway for cellular protection against oxidative damage and provide evidence that TAp73 is a stress-response gene and a downstream effector in the p53 pathway. ..
  85. Ming L, Sakaida T, Yue W, Jha A, Zhang L, Yu J. Sp1 and p73 activate PUMA following serum starvation. Carcinogenesis. 2008;29:1878-84 pubmed publisher
    ..b>p73 was found to be upregulated by serum starvation and mediate PUMA induction through the p53-binding sites in the ..
  86. Sang M, Ando K, Okoshi R, Koida N, Li Y, Zhu Y, et al. Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation. Genes Cells. 2009;14:775-88 pubmed publisher
    ..In this study, we found that Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation...
  87. John K, Alla V, Meier C, Pützer B. GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria. Cell Death Differ. 2011;18:874-86 pubmed publisher
    b>p73, a member of the p53 family, shares high sequence homology with p53 and shows many p53-like properties: it binds to p53-DNA target sites, transactivates p53-responsive genes and induces cell cycle arrest and apoptosis...
  88. Testoni B, Schinzari V, Guerrieri F, Gerbal Chaloin S, Blandino G, Levrero M. p53-paralog DNp73 oncogene is repressed by IFN?/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor. Oncogene. 2011;30:2670-8 pubmed publisher
    The DNp73 proteins act as trans-repressors of p53 and p73-dependent transcription and exert both anti-apoptotic activity and pro-proliferative activity...
  89. Conforti F, Sayan A, Sreekumar R, Sayan B. Regulation of p73 activity by post-translational modifications. Cell Death Dis. 2012;3:e285 pubmed publisher
    The transcription factor p73 is a member of the p53 family that can be expressed as at least 24 different isoforms with pro- or anti-apoptotic attributes...
  90. Grespi F, Melino G. P73 and age-related diseases: is there any link with Parkinson Disease?. Aging (Albany NY). 2012;4:923-31 pubmed
    b>P73 is a member of the p53 transcription factors family with a prominent role in neurobiology, affecting brain development as well as controlling neuronal survival...
  91. Shimodaira H, Yoshioka Yamashita A, Kolodner R, Wang J. Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin. Proc Natl Acad Sci U S A. 2003;100:2420-5 pubmed
    ..MMR-deficient cells exhibit variable defects in the induction of p53 and its related p73, which are activators of apoptosis...
  92. Gaiddon C, Lokshin M, Gross I, Levasseur D, Taya Y, Loeffler J, et al. Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73. J Biol Chem. 2003;278:27421-31 pubmed
    b>p73 transcription factors are members of the p53 family and participate in developmental processes and DNA damage response...