p70S6K

Summary

Gene Symbol: p70S6K
Description: ribosomal protein S6 kinase B1
Alias: PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70 S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha, ribosomal protein S6 kinase beta-1, p70 S6 kinase, alpha, ribosomal protein S6 kinase I, ribosomal protein S6 kinase, 70kDa, polypeptide 1, serine/threonine kinase 14 alpha, serine/threonine-protein kinase 14A
Species: human

Top Publications

  1. ncbi Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes
    P T Pham
    Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cell Biochem 79:427-41. 2000
  2. doi Treatment with TNF-alpha and IFN-gamma alters the activation of SER/THR protein kinases and the metabolic response to IGF-I in mouse c2c12 myogenic cells
    Katarzyna Grzelkowska-Kowalczyk
    Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences SGGW, Nowoursynowska 159, 02 776, Warsaw, Poland
    Cell Mol Biol Lett 15:13-31. 2010
  3. ncbi A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1
    Rebecca A Bachmann
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Avenue, Urbana, IL 61801, USA
    J Biol Chem 281:7357-63. 2006
  4. pmc Hepatitis C virus activates the mTOR/S6K1 signaling pathway in inhibiting IRS-1 function for insulin resistance
    Sandip K Bose
    Department of Internal Medicine, Saint Louis University, St Louis, Missouri, USA
    J Virol 86:6315-22. 2012
  5. ncbi Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway
    M Ueno
    Department of Internal Medicine, State University of Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Diabetologia 48:506-18. 2005
  6. ncbi p21-activated kinase 1 is activated through the mammalian target of rapamycin/p70 S6 kinase pathway and regulates the replication of hepatitis C virus in human hepatoma cells
    Hisashi Ishida
    Center for Hepatitis Research, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas 77555 1018, USA
    J Biol Chem 282:11836-48. 2007
  7. pmc Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1)
    Malik M Keshwani
    Department of Pharmacology, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 286:23552-8. 2011
  8. doi The prolyl isomerase Pin1 interacts with a ribosomal protein S6 kinase to enhance insulin-induced AP-1 activity and cellular transformation
    Na Yeon Lee
    College of Pharmacy, Chosun University, Gwangju 501 759, South Korea
    Carcinogenesis 30:671-81. 2009
  9. pmc TBC1D3, a hominoid-specific gene, delays IRS-1 degradation and promotes insulin signaling by modulating p70 S6 kinase activity
    Marisa J Wainszelbaum
    Department of Cell Biology and Physiology, corrected Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 7:e31225. 2012
  10. pmc Osmotic stress regulates mammalian target of rapamycin (mTOR) complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor protein phosphorylation
    Dongoh Kwak
    Division of Molecular and Life Sciences, Pohang University of Science and Technology POSTECH, Pohang, Kyungbuk, Korea
    J Biol Chem 287:18398-407. 2012

Research Grants

  1. Mechanisms of S6K1 Mediated Insulin Resistance
    George Thomas; Fiscal Year: 2010
  2. JAMES RUSSELL SOWERS; Fiscal Year: 2015
  3. JAMES RUSSELL SOWERS; Fiscal Year: 2016
  4. Yuan Xiang Tao; Fiscal Year: 2016
  5. The kinase toolbox: Mapping the spatial and temporal regulation of cell signaling
    Sivaraj Sivaramakrishnan; Fiscal Year: 2013
  6. SAMY LEWIZ HABIB; Fiscal Year: 2016
  7. Alcohol Consumption and Risk of NHL: Role of MTOR Dysfunction
    Ronald B Gartenhaus; Fiscal Year: 2013
  8. Cross-talk between GCN2 and mTOR in integration of nutrient signaling
    MARTHA STIPANUK; Fiscal Year: 2009
  9. Role of dS6 phosphorylation in dTORC1/dS6K mediated longevity in Drosophila
    George Thomas; Fiscal Year: 2012
  10. Jianping Ye; Fiscal Year: 2015

Detail Information

Publications248 found, 100 shown here

  1. ncbi Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes
    P T Pham
    Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cell Biochem 79:427-41. 2000
    Enhanced phosphorylation of the ribosomal protein s6 kinase, p70(s6k), and the translational repressor, 4E-BP1, are associated with either insulin-induced or amino acid-induced protein synthesis...
  2. doi Treatment with TNF-alpha and IFN-gamma alters the activation of SER/THR protein kinases and the metabolic response to IGF-I in mouse c2c12 myogenic cells
    Katarzyna Grzelkowska-Kowalczyk
    Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences SGGW, Nowoursynowska 159, 02 776, Warsaw, Poland
    Cell Mol Biol Lett 15:13-31. 2010
    ..was to compare the effects of TNF-alpha, IL-1beta and IFN-gamma on the activation of protein kinase B (PKB), p70(S6k), mitogen-activated protein kinase (MAPK) and p90( rsk ), and on IGF-I-stimulated glucose uptake and protein ..
  3. ncbi A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1
    Rebecca A Bachmann
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Avenue, Urbana, IL 61801, USA
    J Biol Chem 281:7357-63. 2006
    ..mTOR) regulates nutrient-dependent cell growth and proliferation through cytoplasmic targets, such as S6 kinase 1 (S6K1). Consistent with its main function in the cytoplasm, mTOR is predominantly cytoplasmic...
  4. pmc Hepatitis C virus activates the mTOR/S6K1 signaling pathway in inhibiting IRS-1 function for insulin resistance
    Sandip K Bose
    Department of Internal Medicine, Saint Louis University, St Louis, Missouri, USA
    J Virol 86:6315-22. 2012
    ..further examined the status of total IRS-1 and the downstream regulation of the Akt pathway in understanding mTOR/S6K1 signaling using HCV genotype 2a (clone JFH1)-infected hepatocytes...
  5. ncbi Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway
    M Ueno
    Department of Internal Medicine, State University of Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Diabetologia 48:506-18. 2005
    ..Several epidemiological studies have suggested an association between chronic hyperinsulinaemia and insulin resistance. However, the causality of this relationship remains uncertain...
  6. ncbi p21-activated kinase 1 is activated through the mammalian target of rapamycin/p70 S6 kinase pathway and regulates the replication of hepatitis C virus in human hepatoma cells
    Hisashi Ishida
    Center for Hepatitis Research, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas 77555 1018, USA
    J Biol Chem 282:11836-48. 2007
    ..Taken together, the data indicate that p70 S6 kinase activates PAK1 and contributes to phosphatidylinositol 3-kinase- and ERK-mediated regulation of HCV RNA replication...
  7. pmc Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1)
    Malik M Keshwani
    Department of Pharmacology, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 286:23552-8. 2011
    p70 ribosomal protein S6 kinase 1 (S6K1) is regulated by multiple phosphorylation events...
  8. doi The prolyl isomerase Pin1 interacts with a ribosomal protein S6 kinase to enhance insulin-induced AP-1 activity and cellular transformation
    Na Yeon Lee
    College of Pharmacy, Chosun University, Gwangju 501 759, South Korea
    Carcinogenesis 30:671-81. 2009
    ..Here, we show that Pin1 interacts with p70S6K in vitro and ex vivo...
  9. pmc TBC1D3, a hominoid-specific gene, delays IRS-1 degradation and promotes insulin signaling by modulating p70 S6 kinase activity
    Marisa J Wainszelbaum
    Department of Cell Biology and Physiology, corrected Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 7:e31225. 2012
    ..activation of protein phosphatase 2A (PP2A), followed by suppression of T389 phosphorylation on p70 S6 kinase (S6K)...
  10. pmc Osmotic stress regulates mammalian target of rapamycin (mTOR) complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor protein phosphorylation
    Dongoh Kwak
    Division of Molecular and Life Sciences, Pohang University of Science and Technology POSTECH, Pohang, Kyungbuk, Korea
    J Biol Chem 287:18398-407. 2012
    ..Our findings suggest that the molecular link between JNK and Raptor is a potential mechanism by which stress regulates the mTORC1 signaling pathway...
  11. ncbi Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252
    A Balendran
    Medical Research Council Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, Dundee DD1 5EH, Scotland
    J Biol Chem 274:37400-6. 1999
    ..at Thr-412 in unstimulated cells, and a catalytically inactive mutant of PDK1 prevents the phosphorylation of p70 S6K at Thr-412 in insulin-like growth factor 1-stimulated cells...
  12. ncbi Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation
    Stefanie S Schalm
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:11101-6. 2005
    ..mTOR, is a Ser/Thr kinase that promotes cell growth and proliferation by activating ribosomal protein S6 kinase 1 (S6K1)...
  13. ncbi HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones
    C Speth
    Institute for Hygiene, University of Innsbruck and Ludwig Boltzmann Institute for AIDS Research, Austria
    AIDS 14:629-36. 2000
    ..To analyse the effect of HIV-1 transmembrane protein gp41 on cytokine production and chemokine receptor expression in blood and brain...
  14. ncbi SKAR is a specific target of S6 kinase 1 in cell growth control
    Celeste J Richardson
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Curr Biol 14:1540-9. 2004
    ..In mammalian cells, the ribosomal protein S6 kinases, S6K1 and S6K2, lie downstream of mTOR and PI3K, suggesting that translational control through the phosphorylation of S6 ..
  15. ncbi Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site
    Siraj M Ali
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, Cambridge, 02142, USA
    J Biol Chem 280:19445-8. 2005
    ..S6 kinase 1 (S6K1) is the best characterized effector of mTOR, and its regulation serves as a model for mTOR signaling...
  16. ncbi Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling
    Kathleen A Martin
    Division of Vascular Surgery, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Biol Chem 282:36112-20. 2007
    ..reported that rapamycin promotes VSMC differentiation by inhibiting the mammalian target of rapamycin (mTOR) target S6K1. Here, we show that rapamycin activates Akt and induces contractile protein expression in human VSMC in an insulin-..
  17. pmc Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology
    Carey J Oliver
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 22:4690-701. 2002
    ..Neurabin I, a neuronal actin-binding protein, binds protein phosphatase 1 (PP1) and p70 ribosomal S6 protein kinase (p70S6K), both proteins implicated in cytoskeletal dynamics...
  18. ncbi Prolactin activates mammalian target-of-rapamycin through phosphatidylinositol 3-kinase and stimulates phosphorylation of p70S6K and 4E-binding protein-1 in lymphoma cells
    Jessica D Bishop
    Department of Biochemistry and Molecular Biology, Dalhousie University, 5850 College Street, Halifax, Nova Scotia, B3H 1X5 Canada
    J Endocrinol 190:307-12. 2006
    ..The activated mTOR kinase phosphorylates/ activates ribosomal protein S6 kinase (p70S6K) and phosphorylates/inactivates eukaryotic initiation factor 4E-binding protein-1 (4E-BP1), resulting in the ..
  19. ncbi PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex
    Bruno D Fonseca
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 282:24514-24. 2007
    ..However, this has no effect on the phosphorylation of Akt or TSC2 (an Akt substrate). These data place PRAS40 downstream of mTORC1 but upstream of its effectors, such as S6K1 and 4E-BP1.
  20. ncbi Mitotic regulation of ribosomal S6 kinase 1 involves Ser/Thr, Pro phosphorylation of consensus and non-consensus sites by Cdc2
    O Jameel Shah
    Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 278:16433-42. 2003
    ..We report here that ribosomal S6 kinase 1 (S6K1), a protein kinase linked to the translation of ribosomal protein mRNAs, is also subject to regulation by Cdc2 in ..
  21. ncbi IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3'-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells
    Kiyotaka Kawauchi
    Department of Medicine, Daini Hospital, Tokyo Women s Medical University, Arakawa ku, Tokyo, Japan
    J Immunol 174:5261-9. 2005
    ..hTERT was coimmunoprecipitated with Akt, Hsp90, mTOR, and p70 S6 kinase (S6K), suggesting that these molecules form a physical complex...
  22. ncbi Roles of human epidermal growth factor receptor 2, c-jun NH2-terminal kinase, phosphoinositide 3-kinase, and p70 S6 kinase pathways in regulation of cyclin G2 expression in human breast cancer cells
    Xiao Feng Le
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Mol Cancer Ther 6:2843-57. 2007
    ..LY294002), c-jun NH(2)-terminal kinase (SP600125), and mammalian target of rapamycin (mTOR)/p70 S6 kinase (p70S6K; rapamycin) increased cyclin G2 expression...
  23. pmc Oscillatory flow-induced proliferation of osteoblast-like cells is mediated by alphavbeta3 and beta1 integrins through synergistic interactions of focal adhesion kinase and Shc with phosphatidylinositol 3-kinase and the Akt/mTOR/p70S6K pathway
    Ding Yu Lee
    Division of Medical Engineering Research, National Health Research Institutes, Miaoli 350, Taiwan
    J Biol Chem 285:30-42. 2010
    ..5 +/- 4 dynes/cm(2)) to MG63 cells induced sustained activation of phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR/p70S6K (p70S6 kinase) signaling cascades and hence cell proliferation, which was accompanied by increased expression of ..
  24. pmc The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation
    Xinsong Xu
    Department of Oncological Sciences, The Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Mol Cell 30:403-14. 2008
    ..Taken together, our findings demonstrate a key role for the CUL7 E3 in targeting IRS-1 for degradation, a process that may contribute to the regulation of cellular senescence...
  25. pmc Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini
    J R Grove
    Medical Services, Massachusetts General Hospital, Boston
    Mol Cell Biol 11:5541-50. 1991
    ..Transient expression of p70 alpha I and alpha II S6 kinase cDNA in COS cells results in a 2.5- to 4-fold increase in overall S6 kinase activity...
  26. pmc Dual requirement for a newly identified phosphorylation site in p70s6k
    B A Moser
    Department of Growth Control, Friedrich Miescher Institut, Basel, Switzerland
    Mol Cell Biol 17:5648-55. 1997
    The activation of p70s6k is associated with multiple phosphorylations at two sets of sites...
  27. ncbi 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
    D R Alessi
    Department of Biochemistry, MRC Phosphorylation Unit, University of Dundee, Dundee, UK
    Curr Biol 8:69-81. 1998
    ..It is not known which protein kinases phosphorylate and activate p70...
  28. ncbi Phosphorylation and activation of p70s6k by PDK1
    N Pullen
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058, Basel, Switzerland
    Science 279:707-10. 1998
    Activation of the protein p70s6k by mitogens leads to increased translation of a family of messenger RNAs that encode essential components of the protein synthetic apparatus...
  29. pmc RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
    P E Burnett
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 95:1432-7. 1998
    ..Here, we show that RAFT1 directly phosphorylates p70(S6k), 4E-BP1, and 4E-BP2 and that serum stimulates RAFT1 kinase activity with kinetics similar to those of p70(S6k) and ..
  30. ncbi Localization of PS6K to chromosomal region 17q23 and determination of its amplification in breast cancer
    F J Couch
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Cancer Res 59:1408-11. 1999
    ..As part of an examination of expressed sequence tags for novel amplified genes in this region, we identified PS6K amplifications in both breast tumor tissues and cell lines...
  31. ncbi Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro
    S Isotani
    Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    J Biol Chem 274:34493-8. 1999
    ....
  32. pmc Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer
    O Monni
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:5711-6. 2001
    ..In summary, comprehensive analysis of the 17q23 amplicon revealed a limited number of highly expressed genes that may contribute to the more aggressive clinical course observed in breast cancer patients with 17q23-amplified tumors...
  33. pmc Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase
    X Wang
    Division of Molecular Physiology and MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee DD1 5EH, UK
    EMBO J 20:4370-9. 2001
    ..In contrast, regulation of eEF2 by stimuli that activate Erk is insensitive to rapamycin, but blocked by inhibitors of MEK/Erk signalling, consistent with the involvement of p90(RSK1)...
  34. ncbi Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo
    Jose M Lizcano
    Medical Research Council Protein Phosphorylation Unit, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 277:27839-49. 2002
    ..NIMA (never in mitosis, gene A)-related kinase-6 (NEK6) as the enzyme that phosphorylates the hydrophobic motif of S6K1 in vivo...
  35. ncbi mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    Do Hyung Kim
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Cell 110:163-75. 2002
    ..Raptor has a positive role in nutrient-stimulated signaling to the downstream effector S6K1, maintenance of cell size, and mTOR protein expression...
  36. ncbi Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
    Kenta Hara
    Biosignal Research Center, Kobe University, 657 8501, Kobe, Japan
    Cell 110:177-89. 2002
    ..elegans raptor yields an array of phenotypes that closely resemble those produced by inactivation of Ce-TOR. Thus, raptor is an essential scaffold for the mTOR-catalyzed phosphorylation of 4EBP1 and mediates TOR action in vivo...
  37. ncbi G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells
    Ning Gao
    1820 MBR Cancer Center and Dept of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 9300, USA
    Am J Physiol Cell Physiol 287:C281-91. 2004
    ..These results indicate that PI3K mediates G(1) progression and cyclin expression through activation of an AKT/mTOR/p70S6K1 signaling pathway in the ovarian cancer cells...
  38. ncbi Role of the p70(S6K) pathway in regulating the actin cytoskeleton and cell migration
    Leise A Berven
    Molecular Signalling Group, Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Exp Cell Res 296:183-95. 2004
    We have examined the role of endogenous 70-kDa S6 kinase (p70(S6K)) in actin cytoskeletal organization and cell migration in Swiss 3T3 fibroblasts...
  39. pmc The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
    Laura S Harrington
    Cancer Research UK Centre for Cell and Molecular Biology, The Institute of Cancer Research, 237 Fulham Rd, London SW3 6JB, England, UK
    J Cell Biol 166:213-23. 2004
    ..The tuberous sclerosis complex (TSC1-2) suppresses cell growth by negatively regulating a protein kinase, p70S6K (S6K1), which generally requires PI3K signals for its activation...
  40. ncbi Upstream and downstream of mTOR
    Nissim Hay
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, 60607, USA
    Genes Dev 18:1926-45. 2004
    ..We also summarize the roles of mTOR in the control of cell growth and proliferation, as well as its relevance to cancer and synaptic plasticity...
  41. ncbi Rheb binds and regulates the mTOR kinase
    Xiaomeng Long
    Diabetes Unit and Medical Services and Department of Molecular Biology, Massachusetts General Hospital, Boston, 02114, USA
    Curr Biol 15:702-13. 2005
    The target of rapamycin (TOR), in complex with the proteins raptor and LST8 (TOR complex 1), phosphorylates the p70S6K and 4E-BP1 to promote mRNA translation...
  42. ncbi Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase
    Gary G Chiang
    Program in Signal Transduction Research, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 280:25485-90. 2005
    ..In addition, we show that cellular amino acid status, which modulates p70S6 kinase (S6K1) activity via the TSC/Rheb pathway, regulates Ser-2448 phosphorylation...
  43. ncbi Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase
    Marina K Holz
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:26089-93. 2005
    ..We show that S6 kinase 1 (S6K1), but not Akt, directly phosphorylates mTOR in cell-free in vitro system and in cells...
  44. ncbi mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
    Marina K Holz
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 123:569-80. 2005
    In response to nutrients, energy sufficiency, hormones, and mitogenic agents, S6K1 phosphorylates several targets linked to translation...
  45. pmc The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity
    David Shahbazian
    Department of Biochemistry, McGill Cancer Centre, McGill University, Montreal, Quebec, Canada
    EMBO J 25:2781-91. 2006
    ..In response to insulin, eIF4B is phosphorylated on Ser422 by S6K in a rapamycin-sensitive manner...
  46. ncbi Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastoma
    Christopher E Pelloski
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 12:3935-41. 2006
    ..This study was conducted to determine whether any of these markers are associated with survival time and response to radiation in glioblastoma...
  47. pmc Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis
    O Jameel Shah
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell Biol 26:6425-34. 2006
    The TSC1-TSC2/Rheb/Raptor-mTOR/S6K1 cell growth cassette has recently been shown to regulate cell autonomous insulin and insulin-like growth factor I (IGF-I) sensitivity by transducing a negative feedback signal that targets insulin ..
  48. ncbi Reactive oxygen species regulate epidermal growth factor-induced vascular endothelial growth factor and hypoxia-inducible factor-1alpha expression through activation of AKT and P70S6K1 in human ovarian cancer cells
    Ling Zhi Liu
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Free Radic Biol Med 41:1521-33. 2006
    ..This study also indicates that p70S6K1 and H2O2 are important in tumor angiogenesis. The results of the study could have an important implication in ovarian cancer therapy...
  49. ncbi PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
    Yasemin Sancak
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
    Mol Cell 25:903-15. 2007
    ..Insulin stimulates the phosphorylation of S6K1, an mTORC1 substrate, but it is not known how mTORC1 kinase activity is regulated...
  50. ncbi Activation of Akt-mTOR-p70S6K pathway in angiogenesis in hepatocellular carcinoma
    Wei Li
    Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, TX 77030, USA
    Oncol Rep 20:713-9. 2008
    Angiogenesis is an essential process for progression of hepatocellular carcinoma (HCC). The Akt-mTOR-p70S6K signal pathway has been recognized for its roles in regulating neoangiogenesis...
  51. doi Endothelial p70 S6 kinase 1 in regulating tumor angiogenesis
    Ling Zhi Liu
    Department of Pathology, Lab of Reproductive Medicine, Cancer Center, Nanjing Medical University, Nanjing, Jiangsu, China
    Cancer Res 68:8183-8. 2008
    ..This study helps to understand the role and molecular mechanism of p70S6K1 in regulating angiogenesis and tumor growth, and the role of endothelial p70S6K1/HIF-1 signaling in the regulation of tumor microenvironment and angiogenesis...
  52. doi S6 kinase 1 regulates estrogen receptor alpha in control of breast cancer cell proliferation
    Rachel L Yamnik
    Department of Biology, Stern College for Women of Yeshiva University, New York, New York 10016, USA
    J Biol Chem 284:6361-9. 2009
    The 40 S ribosomal S6 kinase 1 (S6K1) acts downstream of mTOR (mammalian target of rapamycin) and is sensitive to inhibition by rapamycin...
  53. pmc Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation
    Tomoko Sunami
    Department of Chemistry, Tsukuba Research Institute, Banyu Pharmaceutical Company, Limited, Tsukuba, Ibaraki, 300 2611, Japan
    J Biol Chem 285:4587-94. 2010
    p70 ribosomal S6 kinase (p70S6K) is a downstream effector of the mTOR signaling pathway involved in cell proliferation, cell growth, cell-cycle progression, and glucose homeostasis...
  54. doi Novel pathway in Bcr-Abl signal transduction involves Akt-independent, PLC-gamma1-driven activation of mTOR/p70S6-kinase pathway
    B Markova
    Department of Medicine Cancer Research, West German Cancer Center, University Hospital, Essen, Germany
    Oncogene 29:739-51. 2010
    ..Suppression of Akt activity alone did not affect phosphorylation of p70-S6K and S6. These results suggested the existence of an alternative mechanism for mTOR/p70S6-K activation...
  55. pmc mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling
    Louis Andre Julien
    Institute for Research in Immunology and Cancer, Department of Pathology and Cell Biology, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Mol Cell Biol 30:908-21. 2010
    ..found that Rictor phosphorylation requires mTORC1 activity and, more specifically, the p70 ribosomal S6 kinase 1 (S6K1)...
  56. doi Functions and regulation of the 70kDa ribosomal S6 kinases
    Tim R Fenton
    Ludwig Institute for Cancer Research, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0660, USA
    Int J Biochem Cell Biol 43:47-59. 2011
    The 70kDa ribosomal protein S6 kinases, S6K1 and S6K2 are two highly homologous serine/threonine kinases that are activated in response to growth factors, cytokines and nutrients...
  57. pmc The IGF pathway regulates ERα through a S6K1-dependent mechanism in breast cancer cells
    Marc A Becker
    Department of Pharmacology, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Mol Endocrinol 25:516-28. 2011
    ..Herein we identify the mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) axis as a critical component of IGF and estrogen receptor (ER)α cross talk...
  58. pmc S6K1 and 4E-BP1 are independent regulated and control cellular growth in bladder cancer
    Roman Nawroth
    Department of Urology, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    PLoS ONE 6:e27509. 2011
    ..Manipulation of mTOR or Akt expression or activity only regulated phosphorylation of S6K1 but not 4E-BP1...
  59. pmc The crosstalk of mTOR/S6K1 and Hedgehog pathways
    Yan Wang
    Department of Molecular and Cellular Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Cell 21:374-87. 2012
    ..In this study, we found that an activated mTOR/S6K1 pathway promotes Gli1 transcriptional activity and oncogenic function through S6K1-mediated Gli1 phosphorylation at ..
  60. pmc The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe
    Nobuyasu Ikai
    Okinawa Institute of Science and Technology Promotion Corporation, 1919 1 Tancha, Onna, Okinawa 904 0412, Japan
    Open Biol 1:110007. 2011
    ..TORC1 and TORC2 coordinate growth, mitosis and cell size control, such as Wee1 and Cdc25 do for the entry into mitosis...
  61. ncbi Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region
    I Gout
    Ludwig Institute for Cancer Research, London W1P 8BY and the Department of Biochemistry and Molecular Biology, University College London, London WC1E 6BT, United Kingdom
    J Biol Chem 273:30061-4. 1998
    ..The p70beta kinase was found to be significantly less sensitive to wortmannin and rapamycin than p70alpha. These results indicate that p70beta has the potential to participate in the regulation of protein synthesis and the cell cycle...
  62. ncbi Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1
    M Barcova
    Institute for Hygiene, University of Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Pflugers Arch 437:538-46. 1999
    ....
  63. ncbi Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site
    Masao Saitoh
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Biol Chem 277:20104-12. 2002
    A critical step in S6 kinase 1 (S6K1) activation is Thr(229) phosphorylation in the activation loop by the phosphoinositide-dependent protein kinase (PDK1)...
  64. pmc Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase
    Xiuwen Tang
    Division of Cell Signalling, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 374:137-43. 2003
    ..cholinergic receptors, coupled to phospholipase C, evoked a persistent 10-20-fold activation of p70 S6 kinase (S6K1)...
  65. ncbi GPx-1 modulates Akt and P70S6K phosphorylation and Gadd45 levels in MCF-7 cells
    Mohamed A Nasr
    Department of Human Nutrition, University of Illinois at Chicago, 60612, USA
    Free Radic Biol Med 37:187-95. 2004
    ..GPx-1 overexpression affected phosphorylation of p70S6K, whereas Erk1/2 and p38 MAPK were not affected...
  66. pmc Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
    Qian Yang
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genes Dev 20:2820-32. 2006
    ..These data demonstrate that Sin1 together with Rictor are key components of mTORC2 and play an essential role in Akt phosphorylation and signaling...
  67. pmc S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2
    Jin Zhang
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 283:35375-82. 2008
    S6K1 (p70S6K) is a serine kinase downstream from Akt in the insulin signaling pathway that is involved in negative feedback regulation of insulin action. S6K1 is also activated by TNF-alpha, a pro-inflammatory cytokine...
  68. doi Post-transcriptional gene silencing of ribosomal protein S6 kinase 1 restores insulin action in leucine-treated skeletal muscle
    A Deshmukh
    Department of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
    Cell Mol Life Sci 66:1457-66. 2009
    ..acute insulin action in primary myotubes via a negative feedback mechanism involving ribosomal protein S6 kinase 1 (S6K1). The effect of S6K1 on glucose metabolism was determined by applying RNA interference (siRNA)...
  69. pmc Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-kappaB dependent AP-1-mediated ICAM-1 expression in breast cancer cells
    Mansoor Ahmed
    National Center for Cell Science NCCS, NCCS Complex, Pune 411 007, India
    Mol Cancer 9:101. 2010
    ....
  70. pmc P70S6K 1 regulation of angiogenesis through VEGF and HIF-1alpha expression
    Chuan xiu Bian
    Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing 210029, China
    Biochem Biophys Res Commun 398:395-9. 2010
    ..Our results suggest that p70S6K1 is required for tumor growth and angiogenesis through HIF-1alpha and VEGF expression, providing a molecular mechanism of human ovarian cancer mediated by p70S6K1 signaling...
  71. pmc ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1)
    Audrey Carriere
    Department of Pathology, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 286:567-77. 2011
    ..Our data provide a novel regulatory mechanism by which mitogenic and oncogenic activation of the Ras/MAPK pathway promotes mTOR signaling...
  72. pmc Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis
    Caterina Nardella
    Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 71:3669-75. 2011
    The S6K1 and S6K2 kinases are considered important mTOR signaling effectors, yet their contribution to tumorigenesis remains unclear...
  73. ncbi Okadaic acid inhibits insulin-induced glucose transport in fetal brown adipocytes in an Akt-independent and protein kinase C zeta-dependent manner
    A M Valverde
    , Centro Mixto CSIC/UCM, Facultad de Farmacia, Universidad Complutense, 28040, Madrid, Spain
    FEBS Lett 472:153-8. 2000
    ..However, activation of Akt/PKB or p70 S6 kinase (p70(s6k)) by insulin remained unaltered...
  74. ncbi Changes of insulin-mediated protein kinases phosphorylation and the expression of IGFBP-3 in skeletal muscle of streptozotocin-diabetic mice
    K Grzelkowska-Kowalczyk
    Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw Agricultural University, Nowoursynowska 159, 02 776 Warsaw, Poland
    Pol J Vet Sci 8:231-40. 2005
    ..the basal and insulin-mediated phosphorylation of protein kinase B (PKB), protein kinase Czeta (PKCzeta), p70(S6k), mitogen-activated protein kinase (MAPK)/p90(rsk) pathway and the expression of IGFBP-3, -4, and -5 in mice ..
  75. pmc Mechanism of PDK1-catalyzed Thr-229 phosphorylation of the S6K1 protein kinase
    Malik M Keshwani
    Department of Chemistry, University of Miami, Coral Gables, Florida 33124, USA
    J Biol Chem 284:22611-24. 2009
    PDK1 (phosphoinositide-dependent protein kinase-1) catalyzes phosphorylation of Thr-229 in the T-loop of S6K1 alpha II (the 70-kDa 40 S ribosomal protein S6 kinase-1 alpha II isoform), and Thr-229 phosphorylation is synergistic with C-..
  76. pmc Possible mechanisms involved in the down-regulation of translation during transient global ischaemia in the rat brain
    C Martín De La Vega
    Departamento de Investigacion, Hospital Ramon y Cajal, Ctra Colmenar Km 9, 28034 Madrid, Spain
    Biochem J 357:819-26. 2001
    ..4E-BP1) phosphorylation levels, eIF4F complex formation, as well as eIF2B and ribosomal protein S6 kinase (p70(S6K)) activities, were determined in different subcellular fractions from the cortex and the hippocampus [the CA1-..
  77. doi Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1
    Ayaz Najafov
    University of Dundee, Scotland, UK
    Biochem J 433:357-69. 2011
    ..or MEF (mouse embryonic fibroblast) cells ablated T-loop residue phosphorylation and activation of SGK isoforms and S6K1 induced by serum or IGF1 (insulin-like growth factor 1)...
  78. doi Methionine deprivation regulates the S6K1 pathway and protein synthesis in avian QM7 myoblasts without activating the GCN2/eIF2 alpha cascade
    Sonia Métayer-Coustard
    INRA, UR83 Recherches Avicoles, Nouzilly, France
    J Nutr 140:1539-45. 2010
    Amino acids modulate mRNA translation through the 70 kDa ribosomal protein S6 kinase (S6K1) and the general control nondepressible 2 protein kinase (GCN2)/eukaryotic initiation factor 2 alpha eIF2 alpha pathways...
  79. pmc S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway
    Mario Pende
    Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland
    Mol Cell Biol 24:3112-24. 2004
    ..In mammals, two genes encoding homologous S6Ks, S6K1 and S6K2, have been identified...
  80. ncbi A potential role for extracellular signal-regulated kinases in prostaglandin F2alpha-induced protein synthesis in smooth muscle cells
    G N Rao
    Division of Cardiology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 274:12925-32. 1999
    ..and phosphatidylinositol 3-kinase (PI3-kinase) and their downstream targets ribosomal protein S6 kinase (p70(S6k)) and eukaryotic initiation factor eIF4E and its regulator 4E-BP1...
  81. ncbi Branched chain amino acids activate messenger ribonucleic acid translation regulatory proteins in human skeletal muscle, and glucocorticoids blunt this action
    Z Liu
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 86:2136-43. 2001
    ..of eukaryotic initiation factor 4E-binding protein 1 (eIF4E-BP1) and ribosomal protein S6 kinase (p70(S6K)) in skeletal muscle of seven healthy volunteers...
  82. doi mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
    Juan M García-Martínez
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 416:375-85. 2008
    ..established that mTORC1 [mTOR (mammalian target of rapamycin) complex 1] phosphorylates the hydrophobic motif of S6K (S6 kinase), whereas mTORC2 (mTOR complex 2) phosphorylates the hydrophobic motif of Akt (also known as protein ..
  83. pmc Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)
    Juan M García-Martínez
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD15EH, Scotland, UK
    Biochem J 421:29-42. 2009
    ..of AGC (protein kinase A/protein kinase G/protein kinase C) family kinases such as Akt (protein kinase B), S6K (p70 ribosomal S6 kinase) and SGK (serum and glucocorticoid protein kinase)...
  84. ncbi Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue
    Christopher J Lynch
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 283:E503-13. 2002
    ..This results in phosphorylation of the ribosomal protein S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E-binding protein-1 (4E-BP1), two proteins involved in the initiation phase of ..
  85. pmc Luteinizing hormone stimulates mammalian target of rapamycin signaling in bovine luteal cells via pathways independent of AKT and mitogen-activated protein kinase: modulation of glycogen synthase kinase 3 and AMP-activated protein kinase
    Xiaoying Hou
    Professor and Director of Research and Development, 983255 Nebraska Medical Center, Omaha, Nebraska 68198 3255, USA
    Endocrinology 151:2846-57. 2010
    ..activation of the LH receptor stimulates the phosphorylation of the MTOR substrates ribosomal protein S6 kinase 1 (S6K1) and eukaryotic translation initiation factor 4E binding protein 1...
  86. ncbi An intracellular calcium signal activates p70 but not p90 ribosomal S6 kinase in liver epithelial cells
    L M Graves
    Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 272:1920-8. 1997
    ..kinase C activity (the phorbol ester 12-O-tetradecanoylphorbol-13-acetate) to activate p70 ribosomal S6 kinase (p70(S6K)) and p90 ribosomal S6 kinase (p90(RSK))...
  87. ncbi AKT-independent phosphorylation of TSC2 and activation of mTOR and ribosomal protein S6 kinase signaling by prostaglandin F2alpha
    Edward W Arvisais
    Olson Center for Women s Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, Nebraska 68198 3255, USA
    J Biol Chem 281:26904-13. 2006
    ..to determine whether PGF2alpha stimulates the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase 1 (S6K1) signaling pathway in steroidogenic luteal cells...
  88. ncbi The S6 kinase signaling pathway in the control of development and growth
    George Thomas
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058, Basel, Switzerland
    Biol Res 35:305-13. 2002
    ..immunosuppressant rapamycin, a bacterial macrolide, in conjunction with dominant interfering and activated forms of S6K1 has helped to establish the role of this signaling cascade in the regulation of growth and proliferation (Dennis ..
  89. ncbi Tissue-specific regulation of 4E-BP1 and S6K1 phosphorylation by alpha-ketoisocaproate
    Fumiaki Yoshizawa
    Department of Animal Science, Utsunomiya University, 350 Mine machi, Utsunomiya, Tochigi 321 8505, Japan
    J Nutr Sci Vitaminol (Tokyo) 50:56-60. 2004
    ..repressor, eukaryotic initiation factor (eIF) 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase (S6K1)...
  90. doi Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway
    Francisco Altamirano
    Facultad de Medicina, Instituto de Ciencias Biomedicas, Centro FONDAP Estudios Moleculares de la Celula, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile
    J Endocrinol 202:299-307. 2009
    ..Testosterone increases the phosphorylation of mTOR and its downstream targets 40S ribosomal protein S6 kinase 1 (S6K1; also known as RPS6KB1) and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1)...
  91. ncbi Developmental decline in components of signal transduction pathways regulating protein synthesis in pig muscle
    Scot R Kimball
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 282:E585-92. 2002
    ..of the eukaryotic initiation factor (eIF)4E-binding protein (4E-BP1) and the ribosomal protein S6 kinase (S6K1). These effects of feeding are substantially reduced with development...
  92. ncbi Glucocorticoids differentially modulate insulin-mediated protein and glycogen synthetic signaling downstream of protein kinase B in rat myocardium
    Yangsong Wu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Endocrinology 145:1161-6. 2004
    ..phosphorylation of eukaryotic initiation factor 4E binding protein 1 (4E-BP1) and ribosomal protein S6 kinase (p70(S6K)) (P < 0.003 for both). Insulin enhanced the phosphorylation of Akt (P < 0.04), 4E-BP1 (P < 0...
  93. ncbi Co-expression of EGF receptor, TGFalpha and S6 kinase is significantly associated with colorectal carcinomas with distant metastases at diagnosis
    Marco Tampellini
    Division of Medical Oncology, Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Regione Gonzole 10, 10043, Orbassano, Turin, Italy
    Virchows Arch 450:321-8. 2007
    ..in colorectal carcinoma (CRC) cells regulates cell adhesion and invasiveness via ribosomal protein S6 kinase (S6K) phosphorylation in pre-clinical studies...
  94. pmc Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
    Andrew R Tee
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:13571-6. 2002
    ..signaling to eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1)...
  95. ncbi Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase delta and S6K1 and regulating cell growth
    Amelia Smyk
    Institute of Biochemistry, Warsaw University, Warsaw, Poland
    FEBS J 273:4728-41. 2006
    ..The screen yielded polymerase delta interacting protein 46 or S6K1 Aly/REF-like target (PDIP46/SKAR), a protein possessing one RNA recognition motif (RRM) and being a protein partner ..
  96. ncbi Alcohol intoxication impairs phosphorylation of S6K1 and S6 in skeletal muscle independently of ethanol metabolism
    Charles H Lang
    Pennsylvania State College of Medicine, Department of Cellular and Molecular Physiology H166, Hershey, PA 17033, USA
    Alcohol Clin Exp Res 28:1758-67. 2004
    ..the ability of alcohol to suppress insulin-like growth factor (IGF)-I stimulation of ribosomal S6 kinase 1 (S6K1) and 4E-BP1 phosphorylation, which are central elements in the signal transduction pathway used to coordinate the ..
  97. pmc mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF
    Katherine M Hannan
    Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, USA
    Mol Cell Biol 23:8862-77. 2003
    ..mTOR) is a key regulator of cell growth acting via two independent targets, ribosomal protein S6 kinase 1 (S6K1) and 4EBP1...
  98. ncbi Contraction-mediated mTOR, p70S6k, and ERK1/2 phosphorylation in aged skeletal muscle
    Jascha D Parkington
    Department of Health Sciences, Boston University, Boston, MA 02215, USA
    J Appl Physiol (1985) 97:243-8. 2004
    ..TA) muscles were assayed for mammalian target of rapamycin (mTOR), 70-kDa ribosomal protein S6 kinase (p70(S6K)), and extracellular signal-regulated kinase (ERK) 1/2 phosphorylation and total protein either at baseline, ..
  99. ncbi Immunohistochemical analysis of Ki-67, PCNA and S6K1/2 expression in human breast cancer
    Valeriy Lyzogubov
    R E Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology NAS of Ukraine, Kyiv, Ukraine
    Exp Oncol 27:141-4. 2005
    To assess the correlation between the expression profiles of ribosomal protein S6 kinase (S6K1/2), Ki-67 nuclear antigen (Ki-67) and proliferating cell nuclear antigen (PCNA) in human breast adenocarcinomas.
  100. pmc Role of mTOR signaling in intestinal cell migration
    J Marc Rhoads
    Div of Gastroenterology, Dept of Pediatrics, Univ of Texas Medical School at Houston, 6431 Fannin St, MSB 7 137, Houston, TX 77030, USA
    Am J Physiol Gastrointest Liver Physiol 291:G510-7. 2006
    ..of the mammalian target of rapamycin (mTOR; FRAP), which is functionally linked to ribosomal protein s6 kinase (p70(s6k)), a kinase that plays a critical regulatory role in the translation of mRNAs and protein synthesis...
  101. pmc Expression, purification, and characterization of a structurally disordered and functional C-terminal autoinhibitory domain (AID) of the 70 kDa 40S ribosomal protein S6 kinase-1 (S6K1)
    Timothy J Ragan
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, P O Box 016129, Miami, FL 33101 6129, USA
    Protein Expr Purif 57:271-9. 2008
    b>S6K1 is a member of the AGC subfamily of serine-threonine protein kinases, whereby catalytic activation requires dual phosphorylation of critical residues in the conserved T-loop (T229) and hydrophobic motif (HM; T389) peptide regions of ..

Research Grants70

  1. Mechanisms of S6K1 Mediated Insulin Resistance
    George Thomas; Fiscal Year: 2010
    ..Here we provide preliminary data in the mouse, showing that one such component, ribosomal protein S6 kinase 1 (S6K1), plays not only a positive role in insulin-induced anabolic responses associated with cell growth, but also a ..
  2. JAMES RUSSELL SOWERS; Fiscal Year: 2015
    ..angiotensin II (ANG II) may promote INS resistance through the mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) signaling pathway...
  3. JAMES RUSSELL SOWERS; Fiscal Year: 2016
    ..activation of the RAAS may promote INS resistance through the mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) signaling pathway...
  4. Yuan Xiang Tao; Fiscal Year: 2016
    ..kinase, controls protein translation via phosphorylation of specific downstream effectors, such as 4E-BP1 and S6K1. Our preliminary work indicates that mu receptor/PI3K/Akt- mediated activation of dorsal horn mTOR participates in ..
  5. The kinase toolbox: Mapping the spatial and temporal regulation of cell signaling
    Sivaraj Sivaramakrishnan; Fiscal Year: 2013
    ..the similarities and differences in the regulation of five closely related AGC kinases (PKA, Akt/PKB, PKC, PDK1 and S6K1)...
  6. SAMY LEWIZ HABIB; Fiscal Year: 2016
    ..OGG1 (protein, activity and mRNA) expression, the incidence of Ser326 mutation in OGG1, and levels of Akt, tuberin, S6K phosphorylation and downstream signals of mTOR in kidney tissue from patients with diabetes, patients with kidney ..
  7. Alcohol Consumption and Risk of NHL: Role of MTOR Dysfunction
    Ronald B Gartenhaus; Fiscal Year: 2013
    ..There is recent evidence suggesting that chronic alcohol intake is associated with suppression of the mTOR/p70 S6K signaling pathway, a pathway that plays key roles in the control of important cellular processes, including cell ..
  8. Cross-talk between GCN2 and mTOR in integration of nutrient signaling
    MARTHA STIPANUK; Fiscal Year: 2009
    ..4E&#8208;BP in response to amino acid deprivation);(2) to determine if the decreased phosphorylation of S6K1 and 4E&#8208;BP1 that is observed in response to amino acid deprivation is due to increased action of a ..
  9. Role of dS6 phosphorylation in dTORC1/dS6K mediated longevity in Drosophila
    George Thomas; Fiscal Year: 2012
    ..b>S6K1 is a well established downstream target of mTORC1 whose deficiency in the mouse has been shown to increase insulin ..
  10. Jianping Ye; Fiscal Year: 2015
    ..Our data suggests that IKK2 and JNK1 signals are integrated in activation of S6K1 in the cytoplasm, and S6K directly phosphorylates IRS-1 at four serine residues...
  11. David R Plas; Fiscal Year: 2016
    ..The ribosomal protein S6 kinase 1 (S6K1) supports glycolysis downstream of oncogenic mutations to support growth and survival...
  12. Norbert Perrimon; Fiscal Year: 2014
    ..as positive or negative feedback regulators by measuring their effect on the phosphorylation levels of ERK, Akt1, S6K and 4E-BP at multiple time points post stimulation...
  13. mTOR in Growth and Protection of Hypertrophying Myocardium
    Dhandapani Kuppuswamy; Fiscal Year: 2012
    ..Akt (protein kinase B) via UPS, and mTORC1, which regulates protein translation and cell size via molecules such as S6K1 and its recently identified substrate, SKAR (S6K1 Aly/REF-like target)...
  14. S6 Kinase, Aging and Age-related Disease
    Brian K Kennedy; Fiscal Year: 2011
    ..Preliminary data presented in this proposal, namely the enhanced longevity of mice lacking S6K1, delimits potential mechanisms...
  15. Integration of IKK and JNK signals in Insulin Resistance
    Jianping Ye; Fiscal Year: 2013
    ..Our data suggests that IKK2 and JNK1 signals may be integrated in the S6K1 activation in the cytoplasm for IRS-1 inhibition...
  16. Amino Acids and Muscle Protein Synthesis
    Robert Wolfe; Fiscal Year: 2006
    ..in an increased phosphorylation of the eIF4E binding protein 1 (4E-BP1) and the 70KDa ribosomal protein S6 kinase (S6K1)...
  17. Solving the elusive mechanism of rapamycin action in lymphocytes
    David A Fruman; Fiscal Year: 2013
    ..There are two S6 kinases, S6K1 and S6K2, but their roles in lymphocyte activation and proliferation have not been reported...
  18. JONATHAN OREN LIPTON; Fiscal Year: 2016
    ..central timekeeper, the suprachiasmatic nucleus (SCN);(2) Demonstrate the physiological requirement for Tsc/mTOR/S6K1-mediated phosphorylation of the crucial clock protein BMAL1 in vivo;(3) Determine the roles of TSC1/2 in sleep ..
  19. Adiponectin effects on leptin signaling in hepatocellular carcinoma
    Neeraj Kumar Saxena; Fiscal Year: 2011
    ..Adiponectin activates AMPK in an LKB1-dependent manner, and inhibits S6K activation demonstrating the involvement of LKB1-AMPK-S6K axis...
  20. The role of the mTOR signaling pathway in ER-positive breast cancer
    MARINA KAUFMAN HOLZ; Fiscal Year: 2013
    ..breast cancer cell proliferation, specifically through estrogenic upregulation of a key mTOR effector, S6 Kinase 1 (S6K1, encoded by the RPS6KB1 gene), and mTORC1- mediated phosphorylation of ER? and 14-3-3?, and a novel protein SPATS2...
  21. Synaptic Plasticity, Memory and Social Behavior
    ITZAMARIE CHEVERE TORRES; Fiscal Year: 2010
    ..protein synthesis-dependent forms of synaptic plasticity, by regulating the phosphorylation of ribosomal S6 kinase (S6K1) and eukaryote initiation factor 4E binding protein (4E-BP), key translation initiation regulators...
  22. Interrupting Akt-S6K1 metabolic control to enhance apoptotic responses in CML
    David R Plas; Fiscal Year: 2012
    ..data in this proposal show that Akt signals increased metabolism and survival through the downstream protein kinase S6K1. Interestingly, S6K1 is also a negative regulator of upstream elements in the PI3K/Akt pathway, acting in a ..
  23. RGS: A Molecular Switch Regulating Irreversible ASM Growth/Contraction in Asthma
    REYNOLD ALEXANDER PANETTIERI; Fiscal Year: 2012
    ..Growth factors require activation of Src, phosphatidylinositol 3-kinase (PI3K) and S6K1 to stimulate ASM growth...
  24. The Role of Angiotensin II on mTOR mediated Tubulointerstitial Fibrosis
    Adam T Whaley Connell; Fiscal Year: 2012
    ..In this context, there has been tremendous interest in targeting reductions in mammalian Target of Rapamycin (mTOR)/S6K1 activity to improve tubulointerstitial fibrosis and kidney function in polycystic and diabetic kidney disease ..
  25. Angelique Bordey; Fiscal Year: 2016
    ..phosphorylates the translational repressor eIF4E binding protein (4E-BP) and p70 ribosomal S6 protein kinase 1 (S6K1). In Aim 1, we will determine whether 4E-BP and/or S6K1 mediate mTOR effects on cortical neuron development...
  26. Joseph A Baur; Fiscal Year: 2016
    ..In mice, ablation of the mTORC1 target S6 kinase 1 (S6K1) mimics salient features of CR, including increases in insulin sensitivity, mitochondrial biogenesis, and lifespan...
  27. Disparities in Breast Cancer: Development and Survival in Hispanic and NHW Women
    Martha L Slattery; Fiscal Year: 2013
    ..and will include enes to be studied include SOC1, SOC2, AKT, FRAP1(alias mTOR), P13K, STK11, AMP, PTEN, VEGF, &S6K1,S6K2, CRP, NFKB, IKB, IL10, IL8, IL6, TNFalpha using an Illumina platform...
  28. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    Martha L Slattery; Fiscal Year: 2012
    ..we describe as a metabolic signaling pathway (SOC1, SOC2, AKT, FRAP1 (mTOR), TSC1, TSC2, P13K, LKB, AMP, PTEN, S6K.VEGF, STAT1, STAT6, JNK1, and pSSMAPK)...
  29. Identification of longevity targets in C. elegans protein translation mutants
    PHILIP RAY MCQUARY; Fiscal Year: 2013
    ..The project will examine the hypothesis that key translational regulatory factors belonging to either S6 kinase (S6K) and/or the group of eukaryotic translation initiation factors (eIFs) can specifically mediate this escape...
  30. CDC42GAP in Insulin Signaling in Hepatocytes
    MATTHEW WILLIAM GROGG; Fiscal Year: 2010
    ..to the insulin signaling pathway in several capacities, mainly that associated with the 70 kDa ribosomal S6 kinase (S6K1) and phosphatidylinositol 3- kinase (PI3K), both of which act in the pathway of mammalian target of rapamycin (mTOR)..
  31. Roles of Drosophila NPY-and Insulin-like Activities in Food Response
    Ping Shen; Fiscal Year: 2010
    ..inhibit the signaling activity of NPFR1 neurons through the insulin-like receptor (lnR)/ribosomal S6 kinase (S6K) pathway...
  32. Leonidas C Platanias; Fiscal Year: 2016
    ..JAK2V617F mouse models will be established in AKT -/-, S6K -/- and Pdcd4 -/- KO mice, and the ability of IFN[unreadable] to induce antileukemic responses in vivo, in the ..
  33. David M Sabatini; Fiscal Year: 2016
    ..and PRAS40, is partially sensitive to rapamycin, and controls cell size through translational regulators like S6K1 and 4E-BP1...
  34. Nutrition-Sensitive Pathways and Germline Proliferation in C. Elegans
    Dorota Z Korta; Fiscal Year: 2012
    ..elegans, with specific effects on germline cell cycle. I am currently investigating the TOR-S6K pathway, another key nutrition-sensitive pathway that is thought to act in concert with the insulin signaling...
  35. Ernesto Bernal-Mizrachi; Fiscal Year: 2015
    ..These studies will evaluate the individual contributions of S6K1 and 4E-BP on regulation of cell growth and proliferation...
  36. Mitotic Regulation of Ribosomal S6 Protein Kinases
    Omar Shah; Fiscal Year: 2004
    ..Three S6 kinases (p70S6K1, p85S6K2, and p54S6K2) derived from two separate genes (S6K1 and S6K2) are currently known, all of which share common regulatory motifs yet are localized to discrete ..
  37. Albert R La Spada; Fiscal Year: 2016
    ..proteinopathy, by crossing HD mice onto a reduced protein translation background, using two different models (S6K1 null and 4E-BP1 transgenic mice)...
  38. Tuberin &hamartin in rapamycin-sensitive &insensitive smooth muscle cell growth
    Usamah S Kayyali; Fiscal Year: 2013
    ..enriched in brain), with downstream constitutive activation of mTOR (mammalian target of rapamycin), S6Kinase (S6K) and S6, leading to increased cellular growth...
  39. Growth regulatory targets of the Tuberous Sclerosis Complex
    ROBERT NEIL EISENMAN; Fiscal Year: 2010
    ..It has two well-characterized targets in humans, S6K and 4EBP, but genetic analysis in Drosophila and mice indicate that these targets cannot account for the striking ..
  40. Julio A Aguirre-Ghiso; Fiscal Year: 2016
    ..alternative pathway to mTOR activation Indeed, ATF6a upregulates the small GTPase Rheb, which in turn induces mTOR-S6K activation, resistance to Rapamycin and survival of dormant tumor cells in vivo...
  41. Radiosensitization of Breast Cancer Cells by Vitamin D3 and Vitamin D Analogs
    Eden Wilson; Fiscal Year: 2012
    ..the levels of crucial mediators involved in the ER stress (elF2a, JNK and XBP-1, PERK, IRE-1) and mTOR (4EBP-1 &S6k1) pathways in MCF-7, MCF-7 Her-2/neu and SKBR3 cells by western blot analysis...
  42. Dipali Sharma; Fiscal Year: 2014
    ..Adiponectin activates AMPK in an LKB1-dependent manner, and inhibits S6K activation demonstrating the involvement of LKB1-AMPK-S6K axis...
  43. Forebrain-hindbrain nutrient-sensing circuits in the regulation of energy homeost
    Clemence Blouet; Fiscal Year: 2013
    ..Her work led to landmark discoveries on the role of hypothalamic amino acid detection through p70 S6 kinase 1 (S6K) in the regulation of energy balance in rodents. During the K99 mentored phase of this proposal, Dr...
  44. Forebrain-hindbrain nutrient-sensing circuits in the regulation of energy homeost
    Clemence Blouet; Fiscal Year: 2012
    ..Her work led to landmark discoveries on the role of hypothalamic amino acid detection through p70 S6 kinase 1 (S6K) in the regulation of energy balance in rodents. During the K99 mentored phase of this proposal, Dr...
  45. Integrin-collagen signaling and control of fibroblast proliferation
    Craig A Henke; Fiscal Year: 2013
    ..This leads to unrestrained PI3K/Akt/S6K1 activity and underlies the pathologic proliferation of IPF fibroblasts on polymerized collagen...
  46. Regulation of Estrogen Signaling by Tuberin and Rheb
    Elizabeth P Henske; Fiscal Year: 2010
    ..E2exposure also rapidly activates S6 Kinase (S6K), a key target of mTOR. Activation of S6K by E2 is inhibited by tuberin expression...
  47. Lung extracellular matrix and tumor progression
    Jesse Roman; Fiscal Year: 2012
    ..This hypothesis will be tested in specific aims designed to: 1) determine the role of Akt/mTOR/S6K1 related pathways in fibronectin-induced proliferation/survival and chemotherapy-induced apoptosis of NSCLC and 2) ..
  48. Xiaolei Xu; Fiscal Year: 2016
    ..In Specific Aim 2, we will discern functions of autophagy and pS6K subpathways in cardiomyopathy via phenotyping two modifier mutants that differentially affect TOR signaling...
  49. Cincinnati Center of Neurofibromatosis Research
    Nancy Ratner; Fiscal Year: 2012
    ..in the development of NF1, whether the effects of these pathways are mediated through constitutive activation of S6K1, and the impact of novel pharmacological inhibitors in models of NF1 in cell culture and in the mouse...
  50. Justin Meyerowitz; Fiscal Year: 2015
    ..mTOR signals through two primary outputs, rpS6 kinase (S6K) and the translation initiation factor eIF4E...
  51. Pharmacodynamic-guided Dose-finding Study of Rapamycin
    Manuel Hidalgo; Fiscal Year: 2005
    ..In Specific Aim # 2 we will confirm that the dose selected in Specific Aim # 1 is effective in inhibiting S6K activity in pair tumor biopsies...
  52. Role of Leucine Metabolism in Leucine Signaling
    CHRISTOPHER JOHN LYNCH; Fiscal Year: 2010
    ..Further, substrates of mTOR, lipin, S6K1 and 4EBP1&2, have been alternatively implicated in either obesity or resistance to obesity...
  53. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    Scot R Kimball; Fiscal Year: 2010
    ..target of rapamycin (mTOR), a serine/threonine kinase that controls phosphorylation of two other protein factors S6K1 and 4E-BP1 that regulate mRNA translation and formation of an active elF4E-elF4G complex and elF4G phosphorylation...
  54. MECHANISMS OF HUMAN AIRWAY MUCOUS CELL HYPERPLASIA
    Linda Martin; Fiscal Year: 2004
    ..g. p70-S6k, cdk2), resulting in an increase of mucus-producing cells...
  55. PHOSPHOINOSITIDE-3 KINASE IN CARDIAC HYPERTROPHY
    Peter Kang; Fiscal Year: 2004
    ..Two known downstream targets of PI3K are the Akt (protein kinase B) and the p70/p85 ribosomal S6 kinase (S6K). However, their role in the cardiac growth in vivo has not been established...
  56. USE OF mTOR INHIBITORS IN B CELL LEUKEMIA
    Stephan Grupp; Fiscal Year: 2009
    ..the effect of TSLP on ALL cells and the response to MTI;(b) assess the effect of TSLP on JAKs, STAT3, STAT5 and S6K1 in primary human ALL and compare it to the response to IL-7;and (c) use SCID/NOD expansion of primary ALL cells to ..
  57. SECRETION AND BIOSYNTHESIS OF INSULIN
    Michael McDaniel; Fiscal Year: 2007
    ..characterize the physiological processes affected by mTOR in response to FFAs, ketones and glucose that include: A) S6K1 phosphorylation and DNA synthesis, B) cell cycle progression and cell proliferation, and C) evaluate these ..
  58. Cell Proliferation Mediated by Tsc1/Tsc2
    Gaurang Daftary; Fiscal Year: 2007
    ..that Tsc1 and Tsc2 function together in the Insulin/PI3K/Akt signaling pathway, downstream of Akt and upstream of S6K. Tsc1, Tsc2, and other upstream components of the pathway affect both cell proliferation and growth, however S6K ..
  59. mTOR Signaling In Chronic Myelogenous Leukemia
    Hung Fan; Fiscal Year: 2009
    ..The mTOR effectors, S6K and 4E-BP1/eIF4E, mediate these effects by regulating ribosome biogenesis and cap-dependent translation...
  60. GANGLIOSIDE SIGNALING CASCADES FOR GLIOMA GROWTH
    Arfaan Rampersaud; Fiscal Year: 2000
    ..cells that are defective for PI3K activation and use them for studying GM1 -mediated activation of Erk2 and p70 s6k. GM1 stimulates Erk2 by a mechanism involving activation of the Raf-1 oncoprotein as well as stimulates p70s6k by ..
  61. Rheb GTPase as chemotherapeutic target for brain tumors
    LAWRENCE QUILLIAM; Fiscal Year: 2009
    ..This lipid phosphatase plays a key role in regulating PI3K/Akt signaling which, through TSC2, activates the mTOR/S6K pathway...
  62. Rapamycin as an Antineoplastic Agent
    Ezra Cohen; Fiscal Year: 2006
    ..between RAPA and inhibition of the known RAPA/mTOR dependent phosphorylation at threonine 389 of p70 S6 kinase (S6K). The relationship between suppression of S6K phosphorylation and RAPA blood levels will also be determined...
  63. Rapamycin-Insensitive Signaling by Rictor-mTOR
    David Sabatini; Fiscal Year: 2009
    ..contains mTOR and two novel proteins, raptor and GbL, and mediates the rapamycin-sensitive roles of mTOR (like S6K1 phosphorylation)...
  64. S6K and mTOR as targets for tuberous sclerosis
    Kun Liang Guan; Fiscal Year: 2003
    ..To demonstrate that TSC1 and TSC2 function through the mammalian target of rapamycin (mTOR); 2. To validate S6K as a key downstream effector of TSC1/ TSC2...
  65. Antiretroviral-Induced Defects in Muscle Protein Synthesis
    Charles H Lang; Fiscal Year: 2010
    ..Such data is needed to both realize the full potential and avoid possible pitfalls of this drug in the long-term treatment of HIV-infected individuals. ..
  66. Myocardial Protein Synthesis After Thermal Injury
    Charles Lang; Fiscal Year: 2005
    ..Overall, the research will elucidate the mechanisms by which myocardial protein synthesis is reduced after thermal injury, leading to the better understanding and treatment of the resulting cardiomyopathy. - ..
  67. MYOCARDIAL PROTEIN SYNTHESIS AFTER ALCOHOL INTOXICATION
    Charles H Lang; Fiscal Year: 2010
    ..test the hypothesis that: 1) Alcohol consumption reduces mTOR activity resulting in dephosphorylation of 4E-BP1 and S6K1, thereby limiting myocardial protein synthesis by reducing formation of active elF4G-elF4E complex;2) Stimulating ..