p63

Summary

Gene Symbol: p63
Description: tumor protein p63
Alias: AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L, CUSP, amplified in squamous cell carcinoma, chronic ulcerative stomatitis protein, keratinocyte transcription factor KET, transformation-related protein 63, tumor protein 63, tumor protein p53-competing protein, tumor protein p63 deltaN isoform delta
Species: human

Top Publications

  1. ncbi Physical interaction with Yes-associated protein enhances p73 transcriptional activity
    S Strano
    Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Rome 00158, Italy
    J Biol Chem 276:15164-73. 2001
  2. ncbi p63 expression profiles in human normal and tumor tissues
    Charles J Di Como
    Division of Molecular Pathology, Department of Pathology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Cancer Res 8:494-501. 2002
  3. pmc Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains
    Pamela Ghioni
    Dipartimento di Genetica e Biologia dei Microrganismi, Milan, Italy
    Mol Cell Biol 22:8659-68. 2002
  4. ncbi Identification of vitamin D receptor as a target of p63
    R Kommagani
    Department of Biochemistry and Molecular Biology, Dayton, OH 45435, USA
    Oncogene 25:3745-51. 2006
  5. doi A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis
    Maddalena Adorno
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padua School of Medicine, viale Colombo 3, 35100 Padua, Italy
    Cell 137:87-98. 2009
  6. pmc TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs
    Xiaohua Su
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Nature 467:986-90. 2010
  7. ncbi p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
    A Yang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 2:305-16. 1998
  8. pmc A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias
    Francesca Moretti
    Department of Dermatology, University of Rome Tor Vergata, Rome, Italy
    J Clin Invest 120:1570-7. 2010
  9. ncbi Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome
    J Celli
    Department of Human Genetics 417, University Hospital Nijmegen, The Netherlands
    Cell 99:143-53. 1999
  10. pmc A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer
    Lambertus A Kiemeney
    Department of Epidemiology, Biostatistics and Health Technology Assessment, Nijmegen, The Netherlands
    Nat Genet 42:415-9. 2010

Research Grants

Detail Information

Publications291 found, 100 shown here

  1. ncbi Physical interaction with Yes-associated protein enhances p73 transcriptional activity
    S Strano
    Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Rome 00158, Italy
    J Biol Chem 276:15164-73. 2001
    ..Overexpression of YAP causes an increase of p73alpha transcriptional activity. Differential interaction of YAP with members of the p53 family may provide a molecular explanation for their functional divergence in signaling...
  2. ncbi p63 expression profiles in human normal and tumor tissues
    Charles J Di Como
    Division of Molecular Pathology, Department of Pathology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Cancer Res 8:494-501. 2002
    The p63 gene, located on chromosome 3q27-28, is a member of the p53 gene family. The product encoded by the p63 gene has been reported to be essential for normal development.
  3. pmc Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains
    Pamela Ghioni
    Dipartimento di Genetica e Biologia dei Microrganismi, Milan, Italy
    Mol Cell Biol 22:8659-68. 2002
    b>p63 is a transcription factor structurally related to the p53 tumor suppressor. The C-terminal region differs from p53's in that it contains a sterile alpha motif (SAM) domain and is subject to multiple alternative splicings...
  4. ncbi Identification of vitamin D receptor as a target of p63
    R Kommagani
    Department of Biochemistry and Molecular Biology, Dayton, OH 45435, USA
    Oncogene 25:3745-51. 2006
    b>p63, a p53 homolog has been shown to play a role in development and cancer. p63 is essential for both commitment of ectoderm to stratified epithelia and for the proliferative potential of epithelial stem cells...
  5. doi A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis
    Maddalena Adorno
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padua School of Medicine, viale Colombo 3, 35100 Padua, Italy
    Cell 137:87-98. 2009
    ..we show that TGFbeta-dependent cell migration, invasion and metastasis are empowered by mutant-p53 and opposed by p63. Mechanistically, TGFbeta acts in concert with oncogenic Ras and mutant-p53 to induce the assembly of a mutant-p53/..
  6. pmc TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs
    Xiaohua Su
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Nature 467:986-90. 2010
    ....
  7. ncbi p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
    A Yang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 2:305-16. 1998
    We describe the cloning of p63, a gene at chromosome 3q27-29 that bears strong homology to the tumor suppressor p53 and to the related gene, p73...
  8. pmc A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias
    Francesca Moretti
    Department of Dermatology, University of Rome Tor Vergata, Rome, Italy
    J Clin Invest 120:1570-7. 2010
    ..Mutations in the p63 and interferon regulatory factor 6 (IRF6) genes have been found in human patients with these syndromes, consistent ..
  9. ncbi Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome
    J Celli
    Department of Human Genetics 417, University Hospital Nijmegen, The Netherlands
    Cell 99:143-53. 1999
    ..families to a region of chromosome 3q27 previously implicated in the EEC-like disorder, limb mammary syndrome (LMS)...
  10. pmc A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer
    Lambertus A Kiemeney
    Department of Epidemiology, Biostatistics and Health Technology Assessment, Nijmegen, The Netherlands
    Nat Genet 42:415-9. 2010
    ..The frequency of rs798766[T] is higher in Ta tumors that carry an activating mutation in FGFR3 than in Ta tumors with wild-type FGFR3. Our results show a link between germline variants, somatic mutations of FGFR3 and risk of UBC...
  11. ncbi p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis
    James W Rocco
    Massachusetts General Hospital Center for Cancer Research and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Cell 9:45-56. 2006
    ..Inhibition of endogenous p63 expression by RNAi induces apoptosis selectively in HNSCC cells that overexpress deltaNp63alpha...
  12. pmc The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers
    Chee Onn Leong
    Massachusetts General Hospital Cancer Center and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    J Clin Invest 117:1370-80. 2007
    ..Here we demonstrated that the p53 family member p63 controls a pathway for p73-dependent cisplatin sensitivity specific to these "triple-negative" tumors...
  13. doi A study of ΔNp63 expression in lung non-small cell carcinomas
    Daisuke Nonaka
    Department of Histopathology, the Christie NHS Foundation Trust, Wilmslow Road, Manchester, UK
    Am J Surg Pathol 36:895-9. 2012
    ..The p63 gene encodes two different N-termini (TA and ΔN)...
  14. ncbi Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinoma
    Maurice Phillip DeYoung
    Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    Cancer Res 66:9362-8. 2006
    b>p63 is essential for normal epithelial development and is overexpressed in the vast majority of squamous cell carcinomas (SCC)...
  15. pmc MicroRNA-203 inhibits cell proliferation by repressing ΔNp63 expression in human esophageal squamous cell carcinoma
    Yang Yuan
    Institute of Cardiothoracic Surgery, Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, PR China
    BMC Cancer 11:57. 2011
    ..This study was performed to investigate the effect of microRNA-203 (miR-203) and ΔNp63 on cell proliferation and the functional connection between miR-203 and ΔNp63 in ESCC...
  16. pmc TAp63 regulates VLA-4 expression and chronic lymphocytic leukemia cell migration to the bone marrow in a CD74-dependent manner
    Inbal Binsky
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Immunol 184:4761-9. 2010
    ..These results could form the basis of novel therapeutic strategies aimed at blocking homing of CLL cells in their return to the BM and attenuating their survival...
  17. pmc RNPC1, an RNA-binding protein and a target of the p53 family, regulates p63 expression through mRNA stability
    Jin Zhang
    Comparative Cancer Center, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 107:9614-9. 2010
    b>P63, a p53 family tumor suppressor, is involved in many cellular processes, including growth suppression and differentiation. Thus, p63 activity needs to be tightly controlled...
  18. pmc Increased numbers of P63-positive/CD117-positive cells in advanced adenoid cystic carcinoma give a poorer prognosis
    Quan Zhou
    Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Dongjiaominxiang No, 1 Dongcheng District, Beijing, China
    Diagn Pathol 7:119. 2012
    ..The other was to analyze the relationship between the expression of CD117 and the histological grade and the prognosis...
  19. pmc Diagnostic utility of p63/P501S double sequential immunohistochemical staining in differentiating urothelial carcinoma from prostate carcinoma
    Malini Srinivasan
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Diagn Pathol 6:67. 2011
    ..We evaluated the diagnostic utility of a dual immunohistochemical stain comprising p63 and P501S (prostein), applied sequentially on a single slide and visualized by double chromogen reaction, in ..
  20. pmc p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53
    G Melino
    Medical Research Council, Toxicology Unit, Hodgkin Building, Leicester University, Leicester, UK
    Cell Death Differ 18:1487-99. 2011
    ..This effect seems mediated at least partially by its ability to physically interact with p63, thus affecting a cell invasion pathway, and accordingly, p63 is deregulated in human cancers...
  21. pmc c-Abl phosphorylation of ΔNp63α is critical for cell viability
    M Yuan
    Centre for Molecular Oncology and Imaging, Institute of Cancer, Barts and the London School of Medicine, Queen Mary University of London, London, UK
    Cell Death Dis 1:e16. 2010
    The p53 family member p63 has been shown to be critical for growth, proliferation and chemosensitivity...
  22. ncbi Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder
    Fumitaka Koga
    Department of Urology and Reproductive Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Clin Cancer Res 9:5501-7. 2003
    b>p63 is proposed to play roles in normal development and differentiation of stratified epithelia including urothelium...
  23. pmc p63 Gene mutations in eec syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype-phenotype correlation
    H van Bokhoven
    Department of Human Genetics, University Medical Centre, Nijmegen, The Netherlands
    Am J Hum Genet 69:481-92. 2001
    ..in 35 individuals affected with SHFM, and in three families with the EEC-like condition limb-mammary syndrome (LMS), which is characterized by ectrodactyly, cleft palate, and mammary-gland abnormalities...
  24. doi Gene expression profiling identifies p63 as a diagnostic marker for giant cell tumor of the bone
    Cheng Han Lee
    Department of Pathology, Stanford University, Stanford, CA, USA
    Mod Pathol 21:531-9. 2008
    ..based on their histopathologic types, and significance analysis of microarray identified several genes including TP73L (encoding the p63 protein) that are significantly highly expressed in GCTOB relative to these other tumors...
  25. doi p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma
    Justin A Bishop
    Department of Surgical Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Mod Pathol 25:405-15. 2012
    ..Although the most frequently recommended squamous marker p63 is extremely sensitive, it suffers from low specificity due to its reactivity in a substantial proportion of lung ..
  26. doi Dominant negative (DeltaN) p63alpha induces drug resistance in hepatocellular carcinoma by interference with apoptosis signaling pathways
    Heiko M Mundt
    Department of Internal Medicine IV, University Hospital, Heidelberg, Germany
    Biochem Biophys Res Commun 396:335-41. 2010
    b>p63 belongs to the family of p53-related transcription factors expressing a variety of isoforms. The Trp63 gene has two promoters that drive the expression of two major p63 isoform subfamilies...
  27. pmc Functional interplay between p63 and p53 controls RUNX1 function in the transition from proliferation to differentiation in human keratinocytes
    I Masse
    Centre de Génétique et de Physiologie Moléculaires et Cellulaires, CNRS UMR5534 Université Lyon I, 43 Bd du 11 Novembre 1918, F 69622 Villeurbanne, France
    Cell Death Dis 3:e318. 2012
    ....
  28. doi Mutant p53 subverts p63 control over KLF4 expression in keratinocytes
    N Cordani
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano Via Celoria 26, Milano, Italy
    Oncogene 30:922-32. 2011
    Genetic experiments established that p63 is crucial for the development and maintenance of pluri-stratified epithelia and KLF4 for the barrier function of the skin. KLF4 is one of the factors that reprogram differentiated cells to iPS...
  29. pmc Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma
    Matthew R Ramsey
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 71:4373-9. 2011
    ..A unifying feature of SCC is high-level expression of the p53-related protein p63 (TP63) in 80% of cases...
  30. doi p63 expression in giant cell-containing lesions of bone and soft tissue
    Gustavo de la Roza
    Department of Pathology, Upstate University Hospital, Syracuse, New York, USA
    Arch Pathol Lab Med 135:776-9. 2011
    Previous studies have demonstrated p63 overexpression in giant cell tumors of bone and advocate its use as a potential diagnostic marker...
  31. doi Overexpression of ΔNp63α induces a stem cell phenotype in MCF7 breast carcinoma cell line through the Notch pathway
    Zhijian Du
    Institute of Basic Medical Sciences and School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Cancer Sci 101:2417-24. 2010
    To elucidate a role of ΔNp63α in breast cancer, the expression levels of p63, estrogen receptor, progesterone receptor, p53, CK5, cerBb-2, and Notch1 were assayed in 50 clinical breast cancer specimens using immunochemistry...
  32. ncbi Diagnostic and prognostic impact of p63 immunoreactivity in renal malignancies
    Burcin Tuna
    Department of Pathology, Dokuz Eylul University Medical Faculty, Inciralti, Izmir, Turkey
    Anal Quant Cytol Histol 31:118-22. 2009
    To determine the ability of p63 reactivity to confirm the diagnosis of urothelial carcinomas (UCs) that present clinically as kidney masses and to determine the association of p63 expression with clinicopathologic features in UCs.
  33. doi TP63 gene mutations in Chinese P63 syndrome patients
    W Yin
    Key Laboratory for Oral Biomedical Engineering of the Ministry of Education, Hospital and School of Stomatology, Wuhan University, Luoyu Road 237, Wuhan 430079, P R China
    J Dent Res 89:813-7. 2010
    ..two Chinese Ectrodactyly-Ectodermal-dysplasia-Cleft lip/palate syndrome (EEC) cases and a Limb-Mammary-Syndrome (LMS) patient to carry out TP63 gene sequencing. Three missense mutation, c.812G>C (Ser271Thr), c...
  34. ncbi Regulation of the cyclin-dependent kinase inhibitor p57Kip2 expression by p63
    Chiara Beretta
    Department of Biomolecular and Biotechnological Sciences, University of Milan, Milan, Italy
    Cell Cycle 4:1625-31. 2005
    ..of transactivation potential of the p57Kip2 promoter, while three other natural p63 mutants, associated to the EEC, LMS and SHFM-4 syndromes, were less affected...
  35. doi Giant cell tumor of bone express p63
    Brendan C Dickson
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
    Mod Pathol 21:369-75. 2008
    b>p63 contributes to skeletal development and tumor formation; however, little is known regarding its activity in the context of bone and soft tissue neoplasms...
  36. pmc p63 identifies keratinocyte stem cells
    G Pellegrini
    Laboratory of Tissue Engineering IDI, Istituto Dermopatico dell Immacolata, 00040 Rome, Italy
    Proc Natl Acad Sci U S A 98:3156-61. 2001
    ..Here we show that the p63 transcription factor, a p53 homologue essential for regenerative proliferation in epithelial development, ..
  37. doi The DeltaNp63 proteins are key allies of BRCA1 in the prevention of basal-like breast cancer
    Niamh E Buckley
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, United Kingdom
    Cancer Res 71:1933-44. 2011
    ..b>p63 family proteins that are structurally related to the p53 suppressor protein are known to function in stem cell ..
  38. ncbi Immunohistochemical expression of p63, p53 and MIB-1 in urinary bladder carcinoma. A tissue microarray study of 158 cases
    Eva Comperat
    Service Central d Anatomie et Cytologie Pathologiques et d Urologie, hôpital La Pitié Salpêtrière, 83, Bd de l Hopital, 75013 Paris, France
    Virchows Arch 448:319-24. 2006
    b>P63 is a member of the p53 family, which plays a role in the differentiation of urothelium and is supposed to play a role in urothelial carcinogenesis...
  39. ncbi Delta Np63 alpha expression is regulated by the phosphoinositide 3-kinase pathway
    Christopher E Barbieri
    Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 278:51408-14. 2003
    b>p63 is a homologue of p53 that functions to maintain progenitor cell populations in stratified epithelia. Delta Np63 alpha is overexpressed in epithelial cancers and has been shown to have oncogenic properties...
  40. doi Tp63 in oral development, neoplasia, and autoimmunity
    R A Romano
    State University of New York at Buffalo, Department of Biochemistry, Buffalo, NY, USA
    J Dent Res 91:125-32. 2012
    The Tp63 gene encodes for multiple isoforms of the p63 transcription factor, a member of the p53 family of proteins...
  41. pmc p63 regulates human keratinocyte proliferation via MYC-regulated gene network and differentiation commitment through cell adhesion-related gene network
    Ning Wu
    Commissariat a l Energie Atomique, Biologie à Grande Echelle, F 38054 Grenoble, France
    J Biol Chem 287:5627-38. 2012
    Although p63 and MYC are important in the control of epidermal homeostasis, the underlying molecular mechanisms governing keratinocyte proliferation or differentiation downstream of these two genes are not completely understood...
  42. pmc TAp63 induces senescence and suppresses tumorigenesis in vivo
    Xuecui Guo
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Nat Cell Biol 11:1451-7. 2009
    b>p63 is distinct from its homologue p53 in that its role as a tumour suppressor is controversial, an issue complicated by the existence of two classes of p63 isoforms...
  43. doi Molecular basis of EEC (ectrodactyly, ectodermal dysplasia, clefting) syndrome: five new mutations in the DNA-binding domain of the TP63 gene and genotype-phenotype correlation
    S E Clements
    Genetic Skin Disease Group, St John s Institute of Dermatology, King s College London Guy s Campus, London, UK
    Br J Dermatol 162:201-7. 2010
    ..We highlight the significant intra- and interfamilial phenotypic variability in affected individuals and outline the emerging paradigm for genotype-phenotype correlation in this inherited ectodermal dysplasia syndrome...
  44. pmc Structural evolution of p53, p63, and p73: implication for heterotetramer formation
    Andreas C Joerger
    Centre for Protein Engineering, Medical Research Council, Hills Road, Cambridge CB2 0QH, United Kingdom
    Proc Natl Acad Sci U S A 106:17705-10. 2009
    Oligomerization of members of the p53 family of transcription factors (p53, p63, and p73) is essential for their distinct functions in cell-cycle control and development...
  45. doi Expression of p63 is the sole independent marker of aggressiveness in localised (stage I-II) Merkel cell carcinomas
    Sofia Asioli
    Department of Biomedical Sciences and Human Oncology, University of Torino, Torino, Italy
    Mod Pathol 24:1451-61. 2011
    ..The same cases were studied for p63 expression by immunohistochemistry, by reverse-transcription PCR (RT-PCR) and TP63 gene status by FISH and for ..
  46. pmc Distinct expression profiles of p63 variants during urothelial development and bladder cancer progression
    Orit Karni-Schmidt
    Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA
    Am J Pathol 178:1350-60. 2011
    ..The lack of p63 isoform-specific antibodies has limited the analysis of the biological significance of p63...
  47. ncbi p63 in laryngeal squamous cell carcinoma: evidence for a role of TA-p63 down-regulation in tumorigenesis and lack of prognostic implications of p63 immunoreactivity
    Giancarlo Pruneri
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Lab Invest 82:1327-34. 2002
    b>p63 is a p53-related gene that encodes for multiple mRNA transcripts with (TA-p63) or without (DeltaN-p63) transactivating properties on p53-responsive genes...
  48. pmc A mutation of the p63 gene in non-syndromic cleft lip
    P Leoyklang
    J Med Genet 43:e28. 2006
    Mutations in the p63 gene (TP63) underlie several monogenic malformation syndromes manifesting cleft lip with or without cleft palate (CL/P). We investigated whether p63 mutations also result in non-syndromic CL/P...
  49. pmc A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism
    Zach Serber
    Graduate Group in Biophysics, University of California San Francisco, San Francisco, California 94143, USA
    Mol Cell Biol 22:8601-11. 2002
    ..The p53 homologue p63, for example, is a tetrameric transcription factor implicated in epithelial development and expressed as at least ..
  50. pmc Genome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivo
    Annie Yang
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 5:e11572. 2010
    The p53 homologs, p63 and p73, share approximately 85% amino acid identity in their DNA-binding domains, but they have distinct biological functions.
  51. ncbi TP63 gene mutation in ADULT syndrome
    J Amiel
    Département de génétique, et Unité INSERM U 393, Hopital Necker Enfants Malades, 149, rue de Sevres, 75743 Paris Cedex 15, France
    Eur J Hum Genet 9:642-5. 2001
    ..with ectrodactyly as a major feature, have been mapped to chromosome 3q27 close by the TP63 locus, namely the LMS and ADULT syndromes. Here, we report on a missense TP63 gene mutation in an isolated ADULT syndrome case...
  52. doi IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias
    Barbara Marinari
    Department of Dermatology, University of Rome Tor Vergata, Rome, Italy
    J Invest Dermatol 129:60-9. 2009
    The transcription factor p63 plays a pivotal role in the development and differentiation of the epidermis and epithelial appendages...
  53. ncbi Endogenous p63 acts as a survival factor for tumour cells of SCCHN origin
    Niklas Thurfjell
    Department of Medical Biosciences Pathology, Umea University, SE 901 85 Umea, Sweden
    Int J Mol Med 16:1065-70. 2005
    The human p63 gene encodes a series of proteins that differ in their N- and/or C-terminal sequences and have widely differing properties in promoting or repressing p53-related functions such as growth arrest and apoptosis...
  54. doi Differential altered stability and transcriptional activity of ΔNp63 mutants in distinct ectodermal dysplasias
    Gareth Browne
    Medical Research Council, Leicester University, Leicester LE19HN, UK
    J Cell Sci 124:2200-7. 2011
    Heterozygous mutations of p63, a key transcription factor in epithelial development, are causative in a variety of human ectodermal dysplasia disorders...
  55. pmc A new E6/P63 pathway, together with a strong E7/E2F mitotic pathway, modulates the transcriptome in cervical cancer cells
    Sebastien Teissier
    Unité Expression Génétique et Maladies, CNRS FRE 2850, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Virol 81:9368-76. 2007
    ..study, using new high-density microarrays containing more than 22,000 human cDNA sequences, we identified a novel p63 pathway among E2-activated genes and 38 new mitotic genes repressed by E2...
  56. ncbi The promyelocytic leukaemia protein tumour suppressor functions as a transcriptional regulator of p63
    Francesca Bernassola
    Department of Pathology, Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Oncogene 24:6982-6. 2005
    b>p63 plays unique developmental roles in epidermal morphogenesis, despite its structural similarity with p53...
  57. pmc TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria
    Olav Gressner
    Department of Internal Medicine IV, Hepatology and Gastroenterology, University Hospital, Heidelberg, Germany
    EMBO J 24:2458-71. 2005
    TP63, an important epithelial developmental gene, has significant homology to p53. Unlike p53, the expression of p63 is regulated by two different promoters resulting in proteins with opposite functions: the full-length transcriptionally ..
  58. pmc The p53 homologue DeltaNp63alpha interacts with the nuclear factor-kappaB pathway to modulate epithelial cell growth
    Kathryn E King
    Division of Monoclonal Antibodies, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Cancer Res 68:5122-31. 2008
    ..This is the first report indicating that high levels of DeltaNp63alpha interact with activated c-Rel in keratinocytes and SCC, thereby promoting uncontrolled proliferation, a key alteration in the pathogenesis of cancers...
  59. ncbi DeltaNp63 expression is associated with poor survival in ovarian cancer
    S Marchini
    Laboratory of Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Ann Oncol 19:501-7. 2008
    b>P63 belongs to the 'p53 family' whose role in cancer progression has been recently revisited in light of the plethora of splicing variants that are generated...
  60. ncbi Expression of p63 in cutaneous metastases
    Jean Kanitakis
    Laboratory of Dermatopathology, Ed Herriot Hospital, Lyon, France
    Am J Clin Pathol 128:753-8. 2007
    b>p63 is an oncogene belonging to the p53 gene family...
  61. doi Overexpression of p63 is associated with radiation resistance and prognosis in oral squamous cell carcinoma
    Maximilian Moergel
    Department of Oral and Maxillofacial Surgery, University of Mainz, Medical Center, Mainz, Germany
    Oral Oncol 46:667-71. 2010
    The tumor suppressor homologue p63 is expressed in basal and parabasal layers of intraoral mucosa...
  62. pmc ΔNp63α represses anti-proliferative genes via H2A.Z deposition
    Corrie L Gallant-Behm
    Howard Hughes Medical Institute
    Genes Dev 26:2325-36. 2012
    ..Z whose depletion suffices to reverse the arrest phenotype caused by ΔNp63α knockdown. Collectively, these results illuminate a molecular pathway contributing to the autonomous oncogenic effects of ΔNp63α...
  63. ncbi A novel mutation of p63 in a Chinese family with inherited syndactyly and adactylism
    Tongxiu Luo
    The Center for Heart Development, Key Lab of MOE for Development Biology and Protein Chemistry, College of Life Science, Hunan Normal University, Changsha 410081, Hunan, PR China
    Mutat Res 637:182-9. 2008
    b>p63 is a transcription factor homologous to p53 and p73; mutations in this gene have been identified in individuals with several types of developmental abnormalities, including EEC (ectrodactyly, ectodermal dysplasia, facial clefts) ..
  64. ncbi The EEC syndrome and SHFM: report of two cases and mutation analysis of p63 gene
    Hacer Ergin
    Department of Pediatrics, Pamukkale University Faculty of Medicine, Denizli, Turkey
    Turk J Pediatr 52:529-33. 2010
    The p63 gene is a transcription factor and a member of the p53 family. Heterozygote mutation of the p63 gene is suggested in a number of human syndromes including limb development and/or ectodermal dysplasia...
  65. pmc ΔNp63 versatilely regulates a Broad NF-κB gene program and promotes squamous epithelial proliferation, migration, and inflammation
    Xinping Yang
    Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 71:3688-700. 2011
    ..Np63 with cRel and/or RelA are recruited to form novel binding complexes on p63 or NF-κB/Rel sites of multitarget gene promoters...
  66. pmc The E3 ubiquitin ligase Itch controls the protein stability of p63
    Mario Rossi
    Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, United Kingdom
    Proc Natl Acad Sci U S A 103:12753-8. 2006
    b>p63, a member of the p53 family of transcription factors, plays an important role in epithelial development, regulating both cell cycle and apoptosis...
  67. ncbi Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63
    J A McGrath
    Department of Cell and Molecular Pathology, St John s Institute of Dermatology, The Guy s, King s College and St Thomas Hospitals Medical School, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Hum Mol Genet 10:221-9. 2001
    ..for example ectrodactyly--ectodermal dysplasia--cleft lip/palate (EEC; OMIM 604292), limb--mammary syndrome (LMS; OMIM 603543), acro-dermato-ungual-lacrimal-tooth syndrome (ADULT; OMIM 103285) and recessive cleft lip/palate--..
  68. doi Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation
    Sibel Aylin Ugur
    Department of Molecular Biology and Genetics, Boaziçi University, Istanbul 34342, Turkey
    Hum Mol Genet 17:2644-53. 2008
    ..Four of the loci were excluded, while in TP63 [tumor protein p63 (SHFM4)], the only known gene responsible for SHFM, we detected in most affected subjects a rare insertion variant (..
  69. ncbi p63
    Natalie A Little
    Department of Molecular and Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Centre, P O Box 9503, 2300 RA Leiden, The Netherlands
    Int J Biochem Cell Biol 34:6-9. 2002
    The p63 gene, a member of the p53 gene family, is expressed into at least six protein isoforms which are divided into two groups, those containing the transcription activation domain (TA isoforms) and those that do not (Delta N isoforms)...
  70. ncbi Split-hand/split-foot malformation with paternal mutation in the p63 gene
    I Witters
    Department of Obstetrics and Gynecology, University of Leuven, Leuven, Belgium
    Prenat Diagn 21:1119-22. 2001
    ..Mutation analysis of the p63 gene on chromosome 3q27 showed a missense mutation 577A-->G (predicting amino acid substitution K193E) in the ..
  71. ncbi Recognition of p63 by the E3 ligase ITCH: Effect of an ectodermal dysplasia mutant
    A Bellomaria
    Dipartimento di Scienze e Tecnologie Chimiche, University of Rome Tor Vergata, Italy
    Cell Cycle 9:3730-9. 2010
    The E3 ubiquitin ligase Itch mediates the degradation of the p63 protein. Itch contains four WW domains which are pivotal for the substrate recognition process...
  72. ncbi The Role of p63 and p73 in tumor formation and progression: coming of age toward clinical usefulness. Commentary re: F. Koga et al., Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of th
    Ute M Moll
    Department of Pathology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    Clin Cancer Res 9:5437-41. 2003
  73. doi DeltaNp63alpha repression of the Notch1 gene supports the proliferative capacity of normal human keratinocytes and cervical cancer cells
    Takashi Yugawa
    Virology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo, Japan
    Cancer Res 70:4034-44. 2010
    The p53 family member p63 is a master regulator of epithelial development...
  74. pmc p63 maintains keratinocyte proliferative capacity through regulation of Skp2-p130 levels
    Simon S McDade
    Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen s University Belfast, Belfast BT9 7BL, UK
    J Cell Sci 124:1635-43. 2011
    b>p63 is a master regulator of proliferation and differentiation in stratifying epithelia, and its expression is frequently altered in carcinogenesis. However, its role in maintaining proliferative capacity remains unclear...
  75. doi Spectrum of p63 mutations in a selected patient cohort affected with ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (AEC)
    Tuula Rinne
    Department of Human Genetics, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Am J Med Genet A 149:1948-51. 2009
    ..syndromes, including ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (AEC) and Rapp Hodgkin syndrome (RHS), which involves varying degrees of ectodermal dysplasia, orofacial clefting and limb malformations...
  76. pmc YAP dysregulation by phosphorylation or ΔNp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets
    R Ehsanian
    Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892 1419, USA
    Oncogene 29:6160-71. 2010
    ..AKT and/or ΔNp63 are potential targets for enhancing YAP-mediated apoptosis and chemosensitivity in HNSCCs...
  77. ncbi DeltaNp63alpha promotes apoptosis of human epidermal keratinocytes
    Ling Zhu
    Department of Physiology and Biophysics, Case School of Medicine, Cleveland, Ohio, USA
    J Invest Dermatol 127:1980-91. 2007
    ..Both deltaNp63alpha and TAp63alpha reduce SCC-13 cell survival. These studies indicate that both deltaNp63alpha and TAp63alpha can negatively regulate keratinocyte survival...
  78. doi Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6
    Sanjay Mukhopadhyay
    Department of Pathology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    Am J Surg Pathol 35:15-25. 2011
    ..biopsies and resections were stained with CK7, TTF-1, napsin A (novel aspartic proteinase of the pepsin family), p63, CK5/6, and 34βE12...
  79. ncbi Yes-associated protein 1 regulates the stability of DeltaNp63alpha
    Aditi Chatterjee
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cell Cycle 9:162-7. 2010
    ..Thus, our results strongly suggest that Yap1 plays a role in the regulation of endogenous DeltaNp63alpha levels and is likely to contribute to the regulation of DeltaNp63alpha, in physiological conditions...
  80. pmc Regulation of p53 family member isoform DeltaNp63alpha by the nuclear factor-kappaB targeting kinase IkappaB kinase beta
    Aditi Chatterjee
    Division of Head and Neck Cancer Research, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 70:1419-29. 2010
    The p53 family gene p63 plays an instrumental role in cellular stress responses including responses to DNA damage...
  81. pmc Split-hand/split-foot malformation is caused by mutations in the p63 gene on 3q27
    P Ianakiev
    Department of Pediatrics, University of Connecticut Health Center, Farmington 06030, USA
    Am J Hum Genet 67:59-66. 2000
    ..Results of gene-targeting studies have demonstrated that p63, a homologue of the cell-cycle regulator TP53, plays a critically important role in regulation of the formation and ..
  82. ncbi Mutational analysis of the p63/p73L/p51/p40/CUSP/KET gene in human cancer cell lines using intronic primers
    K Hagiwara
    Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 59:4165-9. 1999
    ..identification of p73, a second homologue of the human p53 tumor suppressor gene has been reported and named p63/p73L/p51/p40/CUSP/KET...
  83. pmc Loss of p63 expression is associated with tumor progression in bladder cancer
    Marshall J Urist
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Am J Pathol 161:1199-206. 2002
    b>p63, a member of the p53 gene family, encodes multiple proteins that may either transactivate p53 responsive genes (TAp63) or act as a dominant-negative factor toward p53 and p73 (Delta Np63)...
  84. ncbi RACK1 and stratifin target DeltaNp63alpha for a proteasome degradation in head and neck squamous cell carcinoma cells upon DNA damage
    Alexey Fomenkov
    Department of Dermatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell Cycle 3:1285-95. 2004
    ..Our data suggest that modification and down regulation of DeltaNp63alpha is one of the major determinants of the cellular response to DNA damage in human head and neck cancers...
  85. pmc DNA-binding and transactivation activities are essential for TAp63 protein degradation
    Haoqiang Ying
    Department of Biochemistry, Boston University School of Medicine, K423, 715 Albany St, Boston, Massachusetts 02118, USA
    Mol Cell Biol 25:6154-64. 2005
    The p53-related p63 gene encodes six isoforms with differing N and C termini. TAp63 isoforms possess a transactivation domain at the N terminus and are able to transactivate a set of genes, including some targets downstream of p53...
  86. doi WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis
    Y Li
    Center for Cell Biology and Cancer Research, MS355, Albany Medical College, Albany, NY 12208, USA
    Cell Death Differ 15:1941-51. 2008
    ..However, the mechanism of WWP1 action is still largely unknown. p63, a member of the p53 family of transcription factors, has an important function in tumor development by regulating ..
  87. ncbi Cloning and chromosomal mapping of the human p53-related KET gene to chromosome 3q27 and its murine homolog Ket to mouse chromosome 16
    M Augustin
    Fraunhofer Institute of Toxicology and Aerosol Research, Center for Medical Biotechnology and Department of Cell Biology, Nikolai Fuchs Str 1, D 30625 Hannover, Germany
    Mamm Genome 9:899-902. 1998
    b>KET is a member of the newly discovered family of proteins that is related to the tumor suppressor p53. Here we describe the molecular cloning of a human cDNA of 4846 bp encoding a protein of 680 amino acids...
  88. ncbi p53 and Delta Np63 alpha differentially bind and regulate target genes involved in cell cycle arrest, DNA repair and apoptosis
    K L Schavolt
    Department of Biochemistry, Center for Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Oncogene 26:6125-32. 2007
    ....
  89. ncbi p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53
    T S Davison
    Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada
    J Biol Chem 274:18709-14. 1999
    ..Here we report in vitro and in vivo analysis of homo- and hetero-oligomerization of p53 and its homologues, p63 and p73...
  90. pmc Novel in vivo targets of DeltaNp63 in keratinocytes identified by a modified chromatin immunoprecipitation approach
    Barbara Birkaya
    Department of Biochemistry, State University of New York at Buffalo, Buffalo, NY 14214, USA
    BMC Mol Biol 8:43. 2007
    b>p63 is a transcription factor that plays an important role in skin epidermal development and differentiation...
  91. ncbi Gain-of-function mutation in ADULT syndrome reveals the presence of a second transactivation domain in p63
    Pascal H G Duijf
    Department of Human Genetics 417, University Medical Centre Nijmegen, Box 9101, 6500 HB Nijmegen, The Netherlands
    Hum Mol Genet 11:799-804. 2002
    ..syndromes, including ectrodactyly-ectodermal dysplasia-cleft lip/palate (EEC) syndrome, limb-mammary syndrome (LMS), Hay-Wells syndrome and in non-syndromic split-hand/split-foot malformation (SHFM)...
  92. ncbi Physical interaction between Wilms tumor 1 and p73 proteins modulates their functions
    V Scharnhorst
    Laboratory of Molecular Carcinogenesis and Centre for Biomedical Genetics, Leiden University Medical Center, P O Box 9503, 2300 RA Leiden, The Netherlands
    J Biol Chem 275:10202-11. 2000
    ..This, taken together with our finding that WT1 also interacts with p63/KET, another p53 homologue, suggests that association between WT1 and the members of the p53 family of proteins may ..
  93. pmc AIS is an oncogene amplified in squamous cell carcinoma
    K Hibi
    Department of Otolaryngology Head and Neck Surgery, Division of Head and Neck Cancer Research, Johns Hopkins University School of Medicine, 818 Ross Research Building, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
    Proc Natl Acad Sci U S A 97:5462-7. 2000
    ..We named this locus AIS for amplified in squamous cell carcinoma.) Furthermore, amplification of the AIS locus was accompanied by RNA and protein overexpression of ..
  94. pmc Differential recognition of response elements determines target gene specificity for p53 and p63
    Motonobu Osada
    Department of Otolaryngology, Division of Head and Neck Surgery, Johns Hopkins University School of Medicine, 818 Ross Research Building, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
    Mol Cell Biol 25:6077-89. 2005
    b>p63 is a member of the p53 tumor suppressor gene family, which regulates downstream target gene expression by binding to sequence-specific response elements similar to those of p53...
  95. ncbi p300 regulates p63 transcriptional activity
    Mary MacPartlin
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 280:30604-10. 2005
    ..Here we describe a study showing that this coactivator also regulates the transcriptional function of p63. p300 bound to the N-terminal domain of p63gamma, and p63gamma bound to the N terminus of p300 in vitro and in ..
  96. ncbi The protein stability and transcriptional activity of p63alpha are regulated by SUMO-1 conjugation
    Pamela Ghioni
    Department of Biomolecular and Biotechnological Sciences, University of Milan, Milan, Italy
    Cell Cycle 4:183-90. 2005
    ..Four natural p63 mutations, falling within the SAM and post-SAM domain of p63alpha, were found to be altered in their sumoylation ..
  97. ncbi TAp63gamma can substitute for p53 in inducing expression of the maspin tumor suppressor
    Katja Spiesbach
    Department of Internal Medicine II, University of Leipzig, Leipzig, Germany
    Int J Cancer 114:555-62. 2005
    ..Maspin gene expression can be upregulated by the tumor suppressor p53. We tested 7 p53-related proteins of the p63 and p73 families for their ability to induce maspin expression...
  98. ncbi The p53 family member genes are involved in the Notch signal pathway
    Yasushi Sasaki
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, S 1, W 17, Chuo Ku, Sapporo, 060 8556 Japan
    J Biol Chem 277:719-24. 2002
    ..b>p63/p51 and p73 were recently identified as members of the p53 gene family...
  99. pmc Reciprocal regulation of p63 by C/EBP delta in human keratinocytes
    Serena Borrelli
    Dipartimento di Scienze Biomolecolari e Biotecnologie, U, di Milano, Via Celoria 26, 20133 Milano, Italy
    BMC Mol Biol 8:85. 2007
    Genetic experiments have clarified that p63 is a key transcription factor governing the establishment and maintenance of multilayered epithelia. Key to our understanding of p63 strategy is the identification of target genes...
  100. ncbi p63 regulates an adhesion programme and cell survival in epithelial cells
    Danielle K Carroll
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Nat Cell Biol 8:551-61. 2006
    b>p63 is critical for epithelial development yet little is known about the transcriptional programmes it regulates...
  101. ncbi Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells
    Annie Yang
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 24:593-602. 2006
    Using tiled microarrays covering the entire human genome, we identify approximately 5800 target sites for p63, a p53 homolog essential for stratified epithelial development...

Research Grants89

  1. P63 mediators as therapeutic targets in HNSCC
    Leif W Ellisen; Fiscal Year: 2010
    ..Cell Carcinoma (HNSCC) and related cancers, by understanding the function and regulation of the p53 family members p63 and p73. The p53 family of proteins plays a key role in the pathogenesis of HNSCC...
  2. Role of PUMA in EGFR targeted therapy in HNSCC
    Jian Yu; Fiscal Year: 2010
    ..Furthermore, EGFR TKIs induce PUMA through the effects on the p53 family members p63 and p73, but not p53 itself...
  3. INFLAMMATORY NEUROLOGICAL DISEASES
    Iain Campbell; Fiscal Year: 2001
    ..Assays to be used here include analysis of p35 and p40 RNA induction, an anti-IL12 ELISA system, and a bioassay for IL12 using a human lymphoblastoid cell line generated ..
  4. Control of Renal Glutaminase Expression during Acidosis
    Norman Curthoys; Fiscal Year: 2009
    ..HuR and p40-AUF1 bind to the pHRE with high affinity and specificity...
  5. Control of Renal Glutaminase Expression during Acidosis
    Norman P Curthoys; Fiscal Year: 2010
    ..HuR and p40-AUF1 bind to the pHRE with high affinity and specificity...
  6. Control of Renal Glutaminase Expression during Acidosis
    Norman Curthoys; Fiscal Year: 2009
    ..HuR and p40-AUF1 bind to the pHRE with high affinity and specificity...
  7. P63 mediators as therapeutic targets in HNSCC
    LEIF ELLISEN; Fiscal Year: 2009
    ..Cell Carcinoma (HNSCC) and related cancers, by understanding the function and regulation of the p53 family members p63 and p73. The p53 family of proteins plays a key role in the pathogenesis of HNSCC...
  8. THE ROLE OF P40 IN SQUAMOUS CELL CARCINOMA
    David Sidransky; Fiscal Year: 2003
    ..Adapted from the investigator's abstract) The PI has cloned and characterized a novel p53 homolgoue p40 (AIS), one of several variants (p40/51/63/73L) that is encoded by the 3q27-28 gene locus...
  9. Mechanism of Modulation of Interleukin-12 Production by Triptolide
    Xiaojing Ma; Fiscal Year: 2007
    Interleukin-12 (IL-12) is a heterodimeric cytokine composed of the p40 and p35 chains...
  10. ACTIVATION OF NF-KB IN GLIAL CELLS AND CNS OF EAE
    Kalipada Pahan; Fiscal Year: 2009
    ..We have discovered a new group of inducers of NF-kappaB activation [interleukin-12 (IL-12) p40 homodimer (p40-2) and monomer (p40)] in glial cells. It was known that p40-2 and p40 were biologically inactive...
  11. Clinically relevant molecular subtypes in leiomyosarcoma
    JAN MATT VAN DE RIJN; Fiscal Year: 2010
    The current treatment of leiomyosarcoma (LMS), the most common form of sarcoma, involves ineffective systemic therapy that is based on a trial and error approach and on the assumption that tumors called "LMS" form a homogenous group...
  12. MOLECULAR REGULATION OF INTERLEUKIN 12 GENE EXPRESSION
    Xiaojing Ma; Fiscal Year: 2003
    ..IL-12 is a heterodimer consisted to two subunits, p40 and p35 that are encoded on different human chromosomes...
  13. Mechanisms of action IL-23 in relapsing demyelination
    Abdolmohamad Rostami; Fiscal Year: 2007
    Project 3. The Role of IL-23 in CNS Inflammatory DemyelinaUon. We have shown that antibodies against the p40 subunit of interleukin-12 (IL-12) prevent spontaneous and superantigen-induced relapses of experimental autoimmune ..
  14. Pairing of EBI-3 and IL12 p35 To Yield A Novel Regulatory T cell Cytokine
    LAUREN COLLISON; Fiscal Year: 2007
    Epstein barr virus induced gene 3 (EBI-3) is a soluble protein that shares structural similarities to the IL12 p40 chain...
  15. Regulation of IL-12 Expression and Activity by Oncogenes
    Xiaojing Ma; Fiscal Year: 2007
    ..The genes encoding the two heterologous chains of IL-12, p40 and p35 are located on different chromosomes. Together, p40 and p35 form the biologically active IL-12...
  16. The role of p63 in normal epidermal differentiation and ectodermal dysplasias
    MARANKE KOSTER; Fiscal Year: 2007
    Project Summary: Dominant mutations in p63, a transcription factor expressed as six isoforms, underlie the skin fragility syndrome ankyloblepharon ectodermal dysplasia and clefting (AEC)...
  17. P63 Network in Pathogenesis of Ectodermal Dysplasia
    Alexey Fomenkov; Fiscal Year: 2006
    We hypothesize that p63 functions through physical and functional interaction with other cellular proteins contributing in regulation of cell proliferation, differentiation and pathogenesis of skin-related disorders...
  18. NNRTI induced conformational changes in HIV-1 Reverse Transcriptase
    Nicolas Sluis Cremer; Fiscal Year: 2007
    ..RT) is a heterodimeric enzyme consisting of a 66-kDa subunit (termed p66) and a p66- derived 51-kDa subunit (p51)...
  19. Cytoplasmic Reactivation of p53 Family Members
    Charles Walker; Fiscal Year: 2004
    ..leukemia in the soft-shell clam, Mya arenaria, in which clam homologs that we have identified for human p53 and p63/73 proteins are rendered non-functional by their sequestration in the cytoplasm of leukemic clam hemocytes...
  20. P63/IGFBP3/BCL2 Control of Corneal Epithelial Homeostasis
    Danielle M Robertson; Fiscal Year: 2010
    ....
  21. P63/IGFBP3/BCL2 Control of Corneal Epithelial Homeostasis
    DANIELLE ROBERTSON; Fiscal Year: 2009
    ....
  22. Characterization of the Desmosome Protein Perp
    LAURA ATTARDI; Fiscal Year: 2007
    ..Using knockout mice, we recently identified the Perp tetraspan membrane protein as a component of the p63 stratified epithelial development program, where it plays an essential role in desmosome function and epithelial ..
  23. Mechanisms regulating prostate epithelium maintenance and regeneration
    Sabina Signoretti; Fiscal Year: 2010
    ..The p63 gene is selectively expressed in basal cells of various epithelia and is required for epithelial development...
  24. Characterization of the Desmosome Protein Perp
    Laura D Attardi; Fiscal Year: 2010
    ..Using knockout mice, we recently identified the Perp tetraspan membrane protein as a component of the p63 stratified epithelial development program, where it plays an essential role in desmosome function and epithelial ..
  25. Probiotics-derived soluble proteins regulate intestinal inflammation
    Fang Yan; Fiscal Year: 2010
    ..We have successfully purified and cloned two novel LGG-derived soluble proteins (p40 and p75) that prevent cytokine-induced apoptosis through activating Akt in intestinal epithelial cells...
  26. BABOON RESEARCH RESOURCE PROGRAM
    Gary White; Fiscal Year: 2007
    This P40 competitive renewal proposes to continue the aims of the initial grant application and expand the support of research investigators using baboons as models in biomedical and behavioral research...
  27. Viper Resource Center (VRC) at Texas A&M University-Kingsville
    John Perez; Fiscal Year: 2009
    The Viper Resource Center (VRC), P40 competitive renewal, at Texas A&M University-Kingsville proposes to continue the aims of the initial grant application...
  28. Viper Resource Center (VRC) at Texas A&M University-Kingsville
    JOHN CARLOS PEREZ; Fiscal Year: 2010
    The Viper Resource Center (VRC), P40 competitive renewal, at Texas A&M University-Kingsville proposes to continue the aims of the initial grant application...
  29. Viper Resource Center (VRC) at Texas A&M University-Kingsville
    John Perez; Fiscal Year: 2009
    The Viper Resource Center (VRC), P40 competitive renewal, at Texas A&M University-Kingsville proposes to continue the aims of the initial grant application...
  30. Oxytocin, Postnatal Experience & Adult Maternal Behavior
    Cort Pedersen; Fiscal Year: 2006
    ..In Preliminary Studies, rat dams subjected to brief and long daily maternal separations (BMS vs. LMS) during infancy exhibited, respectively, increased and decreased pup-grooming (PG), maternal aggression and ..
  31. ROLE OF IL-23 IN PSORIASIS PATHOGENESIS
    Andrew Blauvelt; Fiscal Year: 2007
    ..IL-23, a recently discovered cytokine that consists of p19 and p40 subunits, is now believed to be critical in the development of several classic autoimmune inflammatory diseases in ..
  32. REGULATION AND FUNCTION OF KERATINS IN THE EPIDERMIS
    DENNIS ROOP; Fiscal Year: 2010
    ..We have recently demonstrated that the transcription factor p63 is the molecular switch for initiation of the epidermal stratification program...
  33. IRON UPTAKE AS A VIRULENCE FACTOR IN PATHOGENIC VIBRIOS
    JORGE CROSA; Fiscal Year: 1993
    ..characterized the essential components of this system: the siderophore anguibactin; the transport proteins OM2 and P40, and regulatory elements controlling their biosynthesis...