p63

Summary

Gene Symbol: p63
Description: tumor protein p63
Alias: AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L, tumor protein 63, amplified in squamous cell carcinoma, chronic ulcerative stomatitis protein, keratinocyte transcription factor KET, transformation-related protein 63, tumor protein p53-competing protein
Species: human
Products:     p63

Top Publications

  1. Yalcin Ozuysal O, Fiche M, Guitierrez M, Wagner K, Raffoul W, Brisken C. Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates. Cell Death Differ. 2010;17:1600-12 pubmed publisher
    ..The p53 homolog, p63, is required for the formation of mammary buds, but its function in the breast after birth is unknown...
  2. Du Z, Li J, Wang L, Bian C, Wang Q, Liao L, et al. Overexpression of ?Np63? induces a stem cell phenotype in MCF7 breast carcinoma cell line through the Notch pathway. Cancer Sci. 2010;101:2417-24 pubmed publisher
    To elucidate a role of ?Np63? in breast cancer, the expression levels of p63, estrogen receptor, progesterone receptor, p53, CK5, cerBb-2, and Notch1 were assayed in 50 clinical breast cancer specimens using immunochemistry...
  3. Melino G. p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ. 2011;18:1487-99 pubmed publisher
    ..This effect seems mediated at least partially by its ability to physically interact with p63, thus affecting a cell invasion pathway, and accordingly, p63 is deregulated in human cancers...
  4. Ergin H, Semerci C, Karakuş Y, Scheffer H, Ergin S, Koltuksuz U, et al. The EEC syndrome and SHFM: report of two cases and mutation analysis of p63 gene. Turk J Pediatr. 2010;52:529-33 pubmed
    The p63 gene is a transcription factor and a member of the p53 family. Heterozygote mutation of the p63 gene is suggested in a number of human syndromes including limb development and/or ectodermal dysplasia...
  5. Marcel V, Petit I, Murray Zmijewski F, Goullet de Rugy T, Fernandes K, Meuray V, et al. Diverse p63 and p73 isoforms regulate ?133p53 expression through modulation of the internal TP53 promoter activity. Cell Death Differ. 2012;19:816-26 pubmed publisher
    ..Here, we report that, in addition to p53, at least four p63/p73 isoforms regulate ?133p53 expression at transcriptional level: p63?, ?Np63?, ?Np63? and ?Np73?...
  6. Kiemeney L, Sulem P, Besenbacher S, Vermeulen S, Sigurdsson A, Thorleifsson G, et al. A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer. Nat Genet. 2010;42:415-9 pubmed publisher
    ..The frequency of rs798766[T] is higher in Ta tumors that carry an activating mutation in FGFR3 than in Ta tumors with wild-type FGFR3. Our results show a link between germline variants, somatic mutations of FGFR3 and risk of UBC. ..
  7. Ehsanian R, Brown M, Lu H, Yang X, Pattatheyil A, Yan B, et al. YAP dysregulation by phosphorylation or ΔNp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets. Oncogene. 2010;29:6160-71 pubmed publisher
    ..AKT and/or ΔNp63 are potential targets for enhancing YAP-mediated apoptosis and chemosensitivity in HNSCCs. ..
  8. Srinivasan M, Parwani A. Diagnostic utility of p63/P501S double sequential immunohistochemical staining in differentiating urothelial carcinoma from prostate carcinoma. Diagn Pathol. 2011;6:67 pubmed publisher
    ..We evaluated the diagnostic utility of a dual immunohistochemical stain comprising p63 and P501S (prostein), applied sequentially on a single slide and visualized by double chromogen reaction, in ..
  9. Zhang J, Jun Cho S, Chen X. RNPC1, an RNA-binding protein and a target of the p53 family, regulates p63 expression through mRNA stability. Proc Natl Acad Sci U S A. 2010;107:9614-9 pubmed publisher
    b>P63, a p53 family tumor suppressor, is involved in many cellular processes, including growth suppression and differentiation. Thus, p63 activity needs to be tightly controlled...

More Information

Publications114 found, 100 shown here

  1. Rinne T, Bolat E, Meijer R, Scheffer H, van Bokhoven H. Spectrum of p63 mutations in a selected patient cohort affected with ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (AEC). Am J Med Genet A. 2009;149A:1948-51 pubmed publisher
    ..syndromes, including ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (AEC) and Rapp Hodgkin syndrome (RHS), which involves varying degrees of ectodermal dysplasia, orofacial clefting and limb malformations...
  2. Suenaga Y, Ozaki T, Tanaka Y, Bu Y, Kamijo T, Tokuhisa T, et al. TATA-binding Protein (TBP)-like Protein Is Engaged in Etoposide-induced Apoptosis through Transcriptional Activation of Human TAp63 Gene. J Biol Chem. 2009;284:35433-40 pubmed publisher
    ..Taken together, our present study identifies a TLP-TAp63 pathway that is further implicated in stress-induced apoptosis. ..
  3. Ramsey M, He L, Forster N, Ory B, Ellisen L. Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma. Cancer Res. 2011;71:4373-9 pubmed publisher
    ..A unifying feature of SCC is high-level expression of the p53-related protein p63 (TP63) in 80% of cases...
  4. Drewelus I, G pfert C, Hippel C, Dickmanns A, Damianitsch K, Pieler T, et al. p63 antagonizes Wnt-induced transcription. Cell Cycle. 2010;9:580-87 pubmed publisher
    The p53 homologue p63/TP73L is required for the proper development of squamous epithelia, mammary glands and limb buds, with some of these tissues also displaying strong canonical Wnt signalling activity...
  5. Parsons J, Saria E, Nakayama M, Vessella R, Sawyers C, Isaacs W, et al. Comprehensive mutational analysis and mRNA isoform quantification of TP63 in normal and neoplastic human prostate cells. Prostate. 2009;69:559-69 pubmed publisher
    ..b>p63 protein is found in the nuclei of basal cells of the normal prostate, yet it is absent in the vast majority of ..
  6. Beyer U, Moll Rocek J, Moll U, Dobbelstein M. Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes. Proc Natl Acad Sci U S A. 2011;108:3624-9 pubmed publisher
    ..An equivalent gene for guarding the male germ line is currently not known. Here we identify hitherto unknown human p63 transcripts with unique 5'-ends derived from incorporated exons upstream of the currently mapped TP63 gene...
  7. Li X, Chen J, Yi Y, Li C, Zhang Y. DNA damage down-regulates ?Np63? and induces apoptosis independent of wild type p53. Biochem Biophys Res Commun. 2012;423:338-43 pubmed publisher
    ..Mounting evidence indicates that p63 proteins, which are homologs of p53, are also involved in apoptosis under certain circumstances...
  8. Mangiulli M, Valletti A, Caratozzolo M, Tullo A, Sbisà E, Pesole G, et al. Identification and functional characterization of two new transcriptional variants of the human p63 gene. Nucleic Acids Res. 2009;37:6092-104 pubmed publisher
    b>p63 belongs to a family of transcription factors, which, while demonstrating striking conservation of functional domains, regulate distinct biological functions...
  9. Yang A, Zhu Z, Kettenbach A, Kapranov P, McKeon F, Gingeras T, et al. Genome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivo. PLoS ONE. 2010;5:e11572 pubmed publisher
    The p53 homologs, p63 and p73, share approximately 85% amino acid identity in their DNA-binding domains, but they have distinct biological functions...
  10. Giacobbe A, Bongiorno Borbone L, Bernassola F, Terrinoni A, Markert E, Levine A, et al. p63 regulates glutaminase 2 expression. Cell Cycle. 2013;12:1395-405 pubmed publisher
    The transcription factor p63 is critical for many biological processes, including development and maintenance of epidermal tissues and tumorigenesis...
  11. Guo X, Keyes W, Papazoglu C, Zuber J, Li W, Lowe S, et al. TAp63 induces senescence and suppresses tumorigenesis in vivo. Nat Cell Biol. 2009;11:1451-7 pubmed publisher
    b>p63 is distinct from its homologue p53 in that its role as a tumour suppressor is controversial, an issue complicated by the existence of two classes of p63 isoforms...
  12. Levine A, Tomasini R, McKeon F, Mak T, Melino G. The p53 family: guardians of maternal reproduction. Nat Rev Mol Cell Biol. 2011;12:259-65 pubmed publisher
    The p53 family of proteins consists of p53, p63 and p73, which are transcription factors that affect both cancer and development. It is now emerging that these proteins also regulate maternal reproduction...
  13. Wu N, Rollin J, Masse I, Lamartine J, Gidrol X. p63 regulates human keratinocyte proliferation via MYC-regulated gene network and differentiation commitment through cell adhesion-related gene network. J Biol Chem. 2012;287:5627-38 pubmed publisher
    Although p63 and MYC are important in the control of epidermal homeostasis, the underlying molecular mechanisms governing keratinocyte proliferation or differentiation downstream of these two genes are not completely understood...
  14. Tran M, Choi W, Wszolek M, Navai N, Lee I, Nitti G, et al. The p63 protein isoform ?Np63? inhibits epithelial-mesenchymal transition in human bladder cancer cells: role of MIR-205. J Biol Chem. 2013;288:3275-88 pubmed publisher
    ..Here we report that the p53 family member and p63 isoform, ?Np63?, promotes miR-205 transcription and controls EMT in human bladder cancer cells...
  15. Jung Y, Qian Y, Yan W, Chen X. Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63. J Invest Dermatol. 2013;133:1178-87 pubmed publisher
    b>p63, a homolog of the tumor-suppressor p53, is essential for the development of the epidermis and limbs. p63 is highly expressed in the epithelial cell layer and acts as a molecular switch that initiates epithelial stratification...
  16. Scheel A, Beyer U, Agami R, Dobbelstein M. Immunofluorescence-based screening identifies germ cell associated microRNA 302 as an antagonist to p63 expression. Cell Cycle. 2009;8:1426-32 pubmed
    The tumor suppressor homologue p63 is required for proper skin and limb development, but specific isoforms of it also act as a "guardian of the germline...
  17. Yuan M, Luong P, Hudson C, Gudmundsdottir K, Basu S. c-Abl phosphorylation of ?Np63? is critical for cell viability. Cell Death Dis. 2010;1:e16 pubmed publisher
    The p53 family member p63 has been shown to be critical for growth, proliferation and chemosensitivity...
  18. Danilov A, Neupane D, Nagaraja A, Feofanova E, Humphries L, DiRenzo J, et al. DeltaNp63alpha-mediated induction of epidermal growth factor receptor promotes pancreatic cancer cell growth and chemoresistance. PLoS ONE. 2011;6:e26815 pubmed publisher
    ..p53 homolog p63 is a transcription factor essential for the development and differentiation of epithelial surfaces...
  19. Scott D, Mungall K, Ben Neriah S, Rogic S, Morin R, Slack G, et al. TBL1XR1/TP63: a novel recurrent gene fusion in B-cell non-Hodgkin lymphoma. Blood. 2012;119:4949-52 pubmed publisher
    ..The recurrence, subtype enrichment, and the remarkably conserved nature of the TP63 portion of the fusion suggest an important functional role in the lymphomas that harbor this event. ..
  20. Jeon Y, Jo M, Yoo H, Hong S, Park J, Ka S, et al. Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15. J Clin Invest. 2012;122:2622-36 pubmed publisher
    ..Treatment of a human mammary epithelial cell line with doxorubicin resulted in ISGylation of the p53 family protein p63. An alternative splice variant of p63, ?Np63?, suppressed the transactivity of other p53 family members, and its ..
  21. Sakiz D, Turkmenoglu T, Kabukcuoglu F. The expression of p63 and p53 in keratoacanthoma and intraepidermal and invasive neoplasms of the skin. Pathol Res Pract. 2009;205:589-94 pubmed publisher
    ..b>p63 is a homologue of the tumor suppressor gene p53, which is expressed in human basal squamous epithelium, and despite ..
  22. Karni Schmidt O, Castillo Martin M, Shen T, Huaishen T, Gladoun N, Domingo Domenech J, et al. Distinct expression profiles of p63 variants during urothelial development and bladder cancer progression. Am J Pathol. 2011;178:1350-60 pubmed publisher
    ..The lack of p63 isoform-specific antibodies has limited the analysis of the biological significance of p63...
  23. Chikh A, Matin R, Senatore V, Hufbauer M, Lavery D, Raimondi C, et al. iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia. EMBO J. 2011;30:4261-73 pubmed publisher
    ..a novel autoregulatory feedback loop which controls crucial physiological activities by linking iASPP to p63, via two previously unreported microRNAs, miR-574-3p and miR-720...
  24. Paris M, Rouleau M, Puceat M, Aberdam D. Regulation of skin aging and heart development by TAp63. Cell Death Differ. 2012;19:186-93 pubmed publisher
    Since the discovery of the TP63 gene in 1998, many studies have demonstrated that ?Np63, a p63 isoform of the p53 gene family, is involved in multiple functions during skin development and in adult stem/progenitor cell regulation...
  25. Zhou Q, Chang H, Zhang H, Han Y, Liu H. Increased numbers of P63-positive/CD117-positive cells in advanced adenoid cystic carcinoma give a poorer prognosis. Diagn Pathol. 2012;7:119 pubmed publisher
    ..A retrospective study of 80 ACC patients was performed. Clinical data were collected, and p63, CD117 were detected by immunohistochemical staining...
  26. Leonard M, Hill N, Grant E, Kadakia M. ?Np63? represses nuclear translocation of PTEN by inhibition of NEDD4-1 in keratinocytes. Arch Dermatol Res. 2013;305:733-9 pubmed publisher
    ..Altogether, these studies suggest that ?Np63?-mediated suppression of nuclear PTEN in basal layer keratinocytes occurs through repression of NEDD4-1. ..
  27. Galli F, Rossi M, D Alessandra Y, De Simone M, Lopardo T, Haupt Y, et al. MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation. J Cell Sci. 2010;123:2423-33 pubmed publisher
    Tight control of p63 protein levels must be achieved under differentiation or apoptotic conditions. Here, we describe a new regulatory pathway for the DeltaNp63alpha protein...
  28. Yuan Y, Zeng Z, Liu X, Gong D, Tao J, Cheng H, et al. MicroRNA-203 inhibits cell proliferation by repressing ?Np63 expression in human esophageal squamous cell carcinoma. BMC Cancer. 2011;11:57 pubmed publisher
    ..Our data implied that miR-203 could inhibit cell proliferation in human ESCC through ?Np63-mediated signal pathway. Therefore, we propose that miR-203 might be used as a therapeutic agent for human ESCC. ..
  29. Yang X, Lu H, Yan B, Romano R, Bian Y, Friedman J, et al. ΔNp63 versatilely regulates a Broad NF-κB gene program and promotes squamous epithelial proliferation, migration, and inflammation. Cancer Res. 2011;71:3688-700 pubmed publisher
    ..Np63 with cRel and/or RelA are recruited to form novel binding complexes on p63 or NF-κB/Rel sites of multitarget gene promoters...
  30. Deutsch G, Zielonka E, Coutandin D, Weber T, Schäfer B, Hannewald J, et al. DNA damage in oocytes induces a switch of the quality control factor TAp63? from dimer to tetramer. Cell. 2011;144:566-76 pubmed publisher
    ..Furthermore, we show that a helix in the oligomerization domain of p63 is crucial for tetramer stabilization and competes with the transactivation domain for the same binding site...
  31. Browne G, Cipollone R, Lena A, Serra V, Zhou H, van Bokhoven H, et al. Differential altered stability and transcriptional activity of ?Np63 mutants in distinct ectodermal dysplasias. J Cell Sci. 2011;124:2200-7 pubmed publisher
    Heterozygous mutations of p63, a key transcription factor in epithelial development, are causative in a variety of human ectodermal dysplasia disorders...
  32. Di Iorio E, Kaye S, Ponzin D, Barbaro V, Ferrari S, Böhm E, et al. Limbal stem cell deficiency and ocular phenotype in ectrodactyly-ectodermal dysplasia-clefting syndrome caused by p63 mutations. Ophthalmology. 2012;119:74-83 pubmed publisher
    ..To describe the ocular phenotype in patients with ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome (MIM#604292) and to determine the pathogenic basis of visual morbidity...
  33. Li Y, Peart M, Prives C. Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation. Mol Cell Biol. 2009;29:3953-63 pubmed publisher
    b>p63, a member of the p53 tumor suppressor family, is essential for the development of epidermis as well as other stratified epithelia...
  34. Cheng C, Wang D, Kao M, Chen J. The growth-promoting effect of KGF on limbal epithelial cells is mediated by upregulation of DeltaNp63alpha through the p38 pathway. J Cell Sci. 2009;122:4473-80 pubmed publisher
    ..Interestingly, p63 was highly expressed in KGF-treated limbal epithelial sheets but not in those treated with HGF...
  35. Yin W, Ye X, Shi L, Wang Q, Jin H, Wang P, et al. TP63 gene mutations in Chinese P63 syndrome patients. J Dent Res. 2010;89:813-7 pubmed publisher
    ..two Chinese Ectrodactyly-Ectodermal-dysplasia-Cleft lip/palate syndrome (EEC) cases and a Limb-Mammary-Syndrome (LMS) patient to carry out TP63 gene sequencing. Three missense mutation, c.812G>C (Ser271Thr), c...
  36. Hsiao Y, Su Y, Tsai H, Mason J, Chou M, Man Y. Increased invasiveness and aggressiveness in breast epithelia with cytoplasmic p63 expression. Int J Biol Sci. 2010;6:428-42 pubmed
    Our previous studies revealed that pregnancy associated breast cancer (PABC) had significantly reduced nuclear p63 expression in myoepithelia, while intense cytoplasmic p63 expression in associated epithelia...
  37. Tuna B, Unlu M, Aslan G, Secil M, Yorukoglu K. Diagnostic and prognostic impact of p63 immunoreactivity in renal malignancies. Anal Quant Cytol Histol. 2009;31:118-22 pubmed
    To determine the ability of p63 reactivity to confirm the diagnosis of urothelial carcinomas (UCs) that present clinically as kidney masses and to determine the association of p63 expression with clinicopathologic features in UCs...
  38. Wang N, Guo L, Rueda B, Tilly J. Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress. EMBO Rep. 2010;11:633-9 pubmed publisher
    The p63 gene product regulates epithelial morphogenesis and female germline integrity...
  39. Bellomaria A, Barbato G, Melino G, Paci M, Melino S. Recognition of p63 by the E3 ligase ITCH: Effect of an ectodermal dysplasia mutant. Cell Cycle. 2010;9:3730-9 pubmed
    The E3 ubiquitin ligase Itch mediates the degradation of the p63 protein. Itch contains four WW domains which are pivotal for the substrate recognition process...
  40. Girardini J, Napoli M, Piazza S, Rustighi A, Marotta C, Radaelli E, et al. A Pin1/mutant p53 axis promotes aggressiveness in breast cancer. Cancer Cell. 2011;20:79-91 pubmed publisher
    ..In breast cancer cells, Pin1 promotes mutant p53 dependent inhibition of the antimetastatic factor p63 and induction of a mutant p53 transcriptional program to increase aggressiveness...
  41. Gallant Behm C, Ramsey M, Bensard C, Nojek I, Tran J, Liu M, et al. ?Np63? represses anti-proliferative genes via H2A.Z deposition. Genes Dev. 2012;26:2325-36 pubmed publisher
    ..Z whose depletion suffices to reverse the arrest phenotype caused by ?Np63? knockdown. Collectively, these results illuminate a molecular pathway contributing to the autonomous oncogenic effects of ?Np63?. ..
  42. Yan W, Zhang Y, Zhang J, Cho S, Chen X. HuR is necessary for mammary epithelial cell proliferation and polarity at least in part via ?Np63. PLoS ONE. 2012;7:e45336 pubmed publisher
    ..Consistent with this, we identified two U-rich elements in the 3'-untranslated region of p63 mRNA, to which HuR specifically binds...
  43. Kommagani R, Leonard M, Lewis S, Romano R, Sinha S, Kadakia M. Regulation of VDR by deltaNp63alpha is associated with inhibition of cell invasion. J Cell Sci. 2009;122:2828-35 pubmed publisher
    The p63 transcription factor has a pivotal role in epithelial morphogenesis. Multiple transcripts of the TP63 gene are generated because of alternative promoter usage and splicing...
  44. Chatterjee A, Chang X, Sen T, Ravi R, Bedi A, Sidransky D. Regulation of p53 family member isoform DeltaNp63alpha by the nuclear factor-kappaB targeting kinase IkappaB kinase beta. Cancer Res. 2010;70:1419-29 pubmed publisher
    The p53 family gene p63 plays an instrumental role in cellular stress responses including responses to DNA damage...
  45. Huang Y, Chuang A, Romano R, Liegeois N, Sinha S, Trink B, et al. Phospho-DeltaNp63alpha/NF-Y protein complex transcriptionally regulates DDIT3 expression in squamous cell carcinoma cells upon cisplatin exposure. Cell Cycle. 2010;9:328-38 pubmed
  46. Mukhopadhyay S, Katzenstein A. Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6. Am J Surg Pathol. 2011;35:15-25 pubmed publisher
    ..biopsies and resections were stained with CK7, TTF-1, napsin A (novel aspartic proteinase of the pepsin family), p63, CK5/6, and 34?E12...
  47. Balboni A, Hutchinson J, DeCastro A, Cherukuri P, Liby K, Sporn M, et al. ?Np63?-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells. Cancer Res. 2013;73:1020-30 pubmed publisher
    ..These studies support a model in which ?Np63?-mediated activation of BMP signaling governs epithelial cell plasticity, EMT, and tumorigenicity during breast cancer initiation and progression. ..
  48. Mattiske S, Ho K, Noll J, Neilsen P, Callen D, Suetani R. TAp63 regulates oncogenic miR-155 to mediate migration and tumour growth. Oncotarget. 2013;4:1894-903 pubmed
    ..We have previously shown that miR-155 is regulated by p63, and here we investigate the role of the major p63 isoforms TAp63 and ?Np63 in this regulation...
  49. Yugawa T, Narisawa Saito M, Yoshimatsu Y, Haga K, Ohno S, Egawa N, et al. DeltaNp63alpha repression of the Notch1 gene supports the proliferative capacity of normal human keratinocytes and cervical cancer cells. Cancer Res. 2010;70:4034-44 pubmed publisher
    The p53 family member p63 is a master regulator of epithelial development...
  50. Miki D, Kubo M, Takahashi A, Yoon K, Kim J, Lee G, et al. Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. Nat Genet. 2010;42:893-6 pubmed publisher
    ..Our results suggest that genetic variation in TP63 may influence susceptibility to lung adenocarcinoma in East Asian populations. ..
  51. de la Roza G. p63 expression in giant cell-containing lesions of bone and soft tissue. Arch Pathol Lab Med. 2011;135:776-9 pubmed publisher
    Previous studies have demonstrated p63 overexpression in giant cell tumors of bone and advocate its use as a potential diagnostic marker...
  52. Vasmatzis G, Johnson S, Knudson R, Ketterling R, Braggio E, Fonseca R, et al. Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas. Blood. 2012;120:2280-9 pubmed publisher
    ..abnormalities were novel TP63 rearrangements encoding fusion proteins homologous to ?Np63, a dominant-negative p63 isoform that inhibits the p53 pathway. TP63 rearrangements were seen in 11 (5...
  53. Higashikawa K, Yoneda S, Tobiume K, Saitoh M, Taki M, Mitani Y, et al. DeltaNp63alpha-dependent expression of Id-3 distinctively suppresses the invasiveness of human squamous cell carcinoma. Int J Cancer. 2009;124:2837-44 pubmed publisher
    b>p63 is a member of the p53 family and DeltaNp63alpha is the dominant-expressing isoform of p63 in basal layer of normal stratified epithelium and human squamous cell carcinoma (SCC) cells...
  54. Chen C, Gorlatova N, Kelman Z, Herzberg O. Structures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elements. Proc Natl Acad Sci U S A. 2011;108:6456-61 pubmed publisher
    Transcription factor p63, a p53 family member, plays a role in epithelial cell development, cell cycle arrest, apoptosis, and tumorigenesis. Point mutations, primarily in the DNA binding domain (p63DBD), lead to malformation syndromes...
  55. Wang Y, Broderick P, Matakidou A, Vijayakrishnan J, Eisen T, Houlston R. Variation in TP63 is associated with lung adenocarcinoma in the UK population. Cancer Epidemiol Biomarkers Prev. 2011;20:1453-62 pubmed publisher
    ..Elucidating the functional basis of this association will be contingent on future fine mapping of the TP63 loci. ..
  56. Asioli S, Righi A, de Biase D, Morandi L, Caliendo V, Picciotto F, et al. Expression of p63 is the sole independent marker of aggressiveness in localised (stage I-II) Merkel cell carcinomas. Mod Pathol. 2011;24:1451-61 pubmed publisher
    ..The same cases were studied for p63 expression by immunohistochemistry, by reverse-transcription PCR (RT-PCR) and TP63 gene status by FISH and for ..
  57. Hosgood H, Wang W, Hong Y, Wang J, Chen K, Chang I, et al. Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia. Hum Genet. 2012;131:1197-203 pubmed publisher
    ..037; allelic risk = 0.82, 95% CI = 0.67-0.99). Our findings provide strong evidence that genetic variation in TP63 is associated with the risk of lung adenocarcinoma among Asian females in the absence of tobacco smoking. ..
  58. Lan Q, Hsiung C, Matsuo K, Hong Y, Seow A, Wang Z, et al. Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet. 2012;44:1330-5 pubmed publisher
    ..3. We observed no evidence of association for lung cancer at 15q25 in never-smoking women in Asia, providing strong evidence that this locus is not associated with lung cancer independent of smoking. ..
  59. Leonard M, Kommagani R, Payal V, Mayo L, Shamma H, Kadakia M. ?Np63? regulates keratinocyte proliferation by controlling PTEN expression and localization. Cell Death Differ. 2011;18:1924-33 pubmed publisher
    ..of Akt activation by phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and the presence of putative p63-binding sites in the pten promoter led us to investigate whether ?Np63? regulates PTEN expression...
  60. Huang Y, Bell L, Okamura J, Kim M, Mohney R, Guerrero Preston R, et al. Phospho-?Np63?/SREBF1 protein interactions: bridging cell metabolism and cisplatin chemoresistance. Cell Cycle. 2012;11:3810-27 pubmed publisher
  61. Nobre A, Albergaria A, Schmitt F. p40: a p63 isoform useful for lung cancer diagnosis - a review of the physiological and pathological role of p63. Acta Cytol. 2013;57:1-8 pubmed publisher
    At present, p63, TTF-1, and Napsin-A are the main immunochemical markers used to distinguish squamous cell carcinoma (SCC) from lung adenocarcinoma (ADC)...
  62. Binsky I, Lantner F, Grabovsky V, Harpaz N, Shvidel L, Berrebi A, et al. TAp63 regulates VLA-4 expression and chronic lymphocytic leukemia cell migration to the bone marrow in a CD74-dependent manner. J Immunol. 2010;184:4761-9 pubmed publisher
    ..These results could form the basis of novel therapeutic strategies aimed at blocking homing of CLL cells in their return to the BM and attenuating their survival. ..
  63. McDade S, Patel D, McCance D. p63 maintains keratinocyte proliferative capacity through regulation of Skp2-p130 levels. J Cell Sci. 2011;124:1635-43 pubmed publisher
    b>p63 is a master regulator of proliferation and differentiation in stratifying epithelia, and its expression is frequently altered in carcinogenesis. However, its role in maintaining proliferative capacity remains unclear...
  64. Romano R, Solomon L, Sinha S. Tp63 in oral development, neoplasia, and autoimmunity. J Dent Res. 2012;91:125-32 pubmed publisher
    The Tp63 gene encodes for multiple isoforms of the p63 transcription factor, a member of the p53 family of proteins...
  65. McDade S, Henry A, Pivato G, Kozarewa I, Mitsopoulos C, Fenwick K, et al. Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40:7190-206 pubmed publisher
    The p63 transcription factor (TP63) is critical in development, growth and differentiation of stratifying epithelia...
  66. Sun R, Zhang Y, Lv Q, Liu B, Jin M, Zhang W, et al. Toll-like receptor 3 (TLR3) induces apoptosis via death receptors and mitochondria by up-regulating the transactivating p63 isoform alpha (TAP63alpha). J Biol Chem. 2011;286:15918-28 pubmed publisher
    ..A p53-related protein, the transactivating p63 isoform ? (TAp63?), was induced by TLR3 activation and contributed to the activation of both the intrinsic and ..
  67. Sen G, Boxer L, Webster D, Bussat R, Qu K, Zarnegar B, et al. ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation. Dev Cell. 2012;22:669-77 pubmed publisher
    ..The epidermal master regulator, p63, bound the ZNF750 promoter and was necessary for its induction...
  68. Ching B, Wittler L, Proske J, Yagnik G, Qi L, Draaken M, et al. p63 (TP73L) a key player in embryonic urogenital development with significant dysregulation in human bladder exstrophy tissue. Int J Mol Med. 2010;26:861-7 pubmed
    ..Several lines of evidence implicate genetic factors in the formation of BEEC. Among them a murine p63+/+ knockout model showed the full picture of classic exstrophy of the bladder and other urogenital defects within ..
  69. Feng Z, Zhang C, Kang H, Sun Y, Wang H, Naqvi A, et al. Regulation of female reproduction by p53 and its family members. FASEB J. 2011;25:2245-55 pubmed publisher
    ..Studies with p63- and p73-knockout mice have demonstrated the involvement of p63 and p73 in female reproduction and their roles in ..
  70. Hu Z, Wu C, Shi Y, Guo H, Zhao X, Yin Z, et al. A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet. 2011;43:792-6 pubmed publisher
    ..12 and 22q12.2) were newly identified in the Chinese population. These results suggest that genetic variants in 3q28, 5p15.33, 13q12.12 and 22q12.2 may contribute to the susceptibility of lung cancer in Han Chinese. ..
  71. Ramsey M, Wilson C, Ory B, Rothenberg S, Faquin W, Mills A, et al. FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma. J Clin Invest. 2013;123:3525-38 pubmed publisher
    ..somatic oncogene-activating mutations, they exhibit frequent overexpression of the p53-related transcription factor p63. We developed an in vivo murine tumor model to investigate the function and key transcriptional programs of p63 in ..
  72. Chiang C, Chu W, Chow S, Chen J. Overexpression of delta Np63 in a human nasopharyngeal carcinoma cell line downregulates CKIs and enhances cell proliferation. J Cell Physiol. 2009;219:117-22 pubmed publisher
    b>p63 belongs to a member of the tumor suppressor protein p53 family. Due to alternative promoter usage, two types of p63 proteins are produced...
  73. Clements S, Techanukul T, Coman D, Mellerio J, McGrath J. Molecular basis of EEC (ectrodactyly, ectodermal dysplasia, clefting) syndrome: five new mutations in the DNA-binding domain of the TP63 gene and genotype-phenotype correlation. Br J Dermatol. 2010;162:201-7 pubmed publisher
    ..We highlight the significant intra- and interfamilial phenotypic variability in affected individuals and outline the emerging paradigm for genotype-phenotype correlation in this inherited ectodermal dysplasia syndrome...
  74. Wu J, Bergholz J, Lu J, Sonenshein G, Xiao Z. TAp63 is a transcriptional target of NF-kappaB. J Cell Biochem. 2010;109:702-10 pubmed publisher
    The p53 homologue p63 encodes multiple protein isoforms either with (TA) or without (DeltaN) the N-terminal transactivation domain...
  75. Buckley N, Conlon S, Jirstrom K, Kay E, Crawford N, O Grady A, et al. The DeltaNp63 proteins are key allies of BRCA1 in the prevention of basal-like breast cancer. Cancer Res. 2011;71:1933-44 pubmed publisher
    ..b>p63 family proteins that are structurally related to the p53 suppressor protein are known to function in stem cell ..
  76. Bishop J, Teruya Feldstein J, Westra W, Pelosi G, Travis W, Rekhtman N. p40 (?Np63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. Mod Pathol. 2012;25:405-15 pubmed publisher
    ..Although the most frequently recommended squamous marker p63 is extremely sensitive, it suffers from low specificity due to its reactivity in a substantial proportion of lung ..
  77. Celardo I, Grespi F, Antonov A, Bernassola F, Garabadgiu A, Melino G, et al. Caspase-1 is a novel target of p63 in tumor suppression. Cell Death Dis. 2013;4:e645 pubmed publisher
    b>p63 is a p53 family transcription factor, which besides unique roles in epithelial development, shares tumor suppressive activity with its homolog p53...
  78. Chakravarti D, Su X, Cho M, Bui N, Coarfa C, Venkatanarayan A, et al. Induced multipotency in adult keratinocytes through down-regulation of ?Np63 or DGCR8. Proc Natl Acad Sci U S A. 2014;111:E572-81 pubmed publisher
    ..Here, we show that the p53 family member and p63 isoform, ?Np63, is a transcriptional activator of a cofactor critical for miRNA processing (DGCR8)...
  79. Joerger A, Rajagopalan S, Natan E, Veprintsev D, Robinson C, Fersht A. Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Proc Natl Acad Sci U S A. 2009;106:17705-10 pubmed publisher
    Oligomerization of members of the p53 family of transcription factors (p53, p63, and p73) is essential for their distinct functions in cell-cycle control and development...
  80. Cordani N, Pozzi S, Martynova E, Fanoni D, Borrelli S, Alotto D, et al. Mutant p53 subverts p63 control over KLF4 expression in keratinocytes. Oncogene. 2011;30:922-32 pubmed publisher
    Genetic experiments established that p63 is crucial for the development and maintenance of pluri-stratified epithelia and KLF4 for the barrier function of the skin. KLF4 is one of the factors that reprogram differentiated cells to iPS...
  81. Qian Y, Jung Y, Chen X. DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation. J Biol Chem. 2011;286:12033-41 pubmed publisher
    The p63 gene, a member of the p53 family, is expressed as TA and ?N isoforms. ?Np63 is the predominant isoform expressed in cells of epithelial origin and frequently overexpressed in cancers...
  82. Wei J, Xue Y, Wu L, Ma J, Yi X, Zhang J, et al. Analysis of large phenotypic variability of EEC and SHFM4 syndromes caused by K193E mutation of the TP63 gene. PLoS ONE. 2012;7:e35337 pubmed publisher
    ..dysplasia (EE), isolated ectodermal dysplasia, and isolated Split Hand/Foot Malformation type 4 (SHFM4)...
  83. Crum C, McKeon F. p63 in epithelial survival, germ cell surveillance, and neoplasia. Annu Rev Pathol. 2010;5:349-71 pubmed publisher
    ..However, although these two fundamental roles of p63 attest to its powerful place in development, its other functions-specifically the apparent capacity of p63, when ..
  84. Moretti F, Marinari B, Lo Iacono N, Botti E, Giunta A, Spallone G, et al. A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias. J Clin Invest. 2010;120:1570-7 pubmed publisher
    ..Mutations in the p63 and interferon regulatory factor 6 (IRF6) genes have been found in human patients with these syndromes, consistent ..
  85. Shiraishi K, Kunitoh H, Daigo Y, Takahashi A, Goto K, Sakamoto H, et al. A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. Nat Genet. 2012;44:900-3 pubmed publisher
    ..4 × 10(-11), OR = 1.20) and 6p21.3 (rs3817963, P(combined) = 2.7 × 10(-10), OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma. ..
  86. Yang C, Hayashida T, Forster N, Li C, Shen D, Maheswaran S, et al. The integrin alpha(v)beta(3-5) ligand MFG-E8 is a p63/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in ER(+) and erbB2(+) breast cancers. Cancer Res. 2011;71:937-45 pubmed publisher
    ..Knockdown, chromatin immunoprecipitation, and reporter assays all showed that p63 regulates MFG-E8 expression, and MFG-E8 knockdowns sensitized triple-negative breast cancers to cisplatin treatment...
  87. Zhang Y, Gu C, Shi H, Zhang A, Kong X, Bao W, et al. Association between C3orf21, TP63 polymorphisms and environment and NSCLC in never-smoking Chinese population. Gene. 2012;497:93-7 pubmed publisher
    ..In addition, the C3orf21 gene may be a potential susceptibility marker for lung adenocarcinoma independent of ethnic background and environmental agents. ..
  88. Candi E, Agostini M, Melino G, Bernassola F. How the TP53 family proteins TP63 and TP73 contribute to tumorigenesis: regulators and effectors. Hum Mutat. 2014;35:702-14 pubmed publisher
    In mammals, the p53 family comprises two additional members, p63 and p73 (hereafter referred to as TP53, TP63, and TP73, respectively)...
  89. Adorno M, Cordenonsi M, Montagner M, Dupont S, Wong C, Hann B, et al. A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Cell. 2009;137:87-98 pubmed publisher
    ..we show that TGFbeta-dependent cell migration, invasion and metastasis are empowered by mutant-p53 and opposed by p63. Mechanistically, TGFbeta acts in concert with oncogenic Ras and mutant-p53 to induce the assembly of a mutant-p53/..
  90. Komatsu S, Takenobu H, Ozaki T, Ando K, Koida N, Suenaga Y, et al. Plk1 regulates liver tumor cell death by phosphorylation of TAp63. Oncogene. 2009;28:3631-41 pubmed publisher
    ..Immunoprecipitation and in vitro pull-down assay showed that p63 binds to the kinase domain of Plk1 through its DNA-binding region...
  91. Chatterjee A, Sen T, Chang X, Sidransky D. Yes-associated protein 1 regulates the stability of DeltaNp63alpha. Cell Cycle. 2010;9:162-7 pubmed
    ..Thus, our results strongly suggest that Yap1 plays a role in the regulation of endogenous DeltaNp63alpha levels and is likely to contribute to the regulation of DeltaNp63alpha, in physiological conditions. ..
  92. Nonaka D. A study of ?Np63 expression in lung non-small cell carcinomas. Am J Surg Pathol. 2012;36:895-9 pubmed publisher
    ..The p63 gene encodes two different N-termini (TA and ?N)...