Genomes and Genes
Gene Symbol: p63
Description: tumor protein p63
Alias: AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L, CUSP, amplified in squamous cell carcinoma, chronic ulcerative stomatitis protein, keratinocyte transcription factor KET, transformation-related protein 63, tumor protein 63, tumor protein p53-competing protein, tumor protein p63 deltaN isoform delta
Publications257 found, 100 shown here
- Richner-Hanhart's syndrome: new ultrastructural observations on skin lesions of two casesS M el Shoura
Department of Pathology, College of Medicine, King Saud University, Abha, Kingdom of Saudi Arabia
Ultrastruct Pathol 21:51-6. 1997New ultrastructural observations are described in skin lesions of two brothers with Richner-Hanhart's syndrome (RHS)...
- p63 is a prostate basal cell marker and is required for prostate developmentS Signoretti
Department of Adult Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
Am J Pathol 157:1769-75. 2000The p53 homologue p63 encodes for different isotypes able to either transactivate p53 reporter genes (TAp63) or act as p53-dominant-negatives (DeltaNp63)...
- Physical interaction with Yes-associated protein enhances p73 transcriptional activityS Strano
Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Rome 00158, Italy
J Biol Chem 276:15164-73. 2001..Overexpression of YAP causes an increase of p73alpha transcriptional activity. Differential interaction of YAP with members of the p53 family may provide a molecular explanation for their functional divergence in signaling...
- Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domainsPamela Ghioni
Dipartimento di Genetica e Biologia dei Microrganismi, Milan, Italy
Mol Cell Biol 22:8659-68. 2002b>p63 is a transcription factor structurally related to the p53 tumor suppressor. The C-terminal region differs from p53's in that it contains a sterile alpha motif (SAM) domain and is subject to multiple alternative splicings...
- Identification of vitamin D receptor as a target of p63R Kommagani
Department of Biochemistry and Molecular Biology, Dayton, OH 45435, USA
Oncogene 25:3745-51. 2006b>p63, a p53 homolog has been shown to play a role in development and cancer. p63 is essential for both commitment of ectoderm to stratified epithelia and for the proliferative potential of epithelial stem cells...
- TAp63 induces senescence and suppresses tumorigenesis in vivoXuecui Guo
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Nat Cell Biol 11:1451-7. 2009b>p63 is distinct from its homologue p53 in that its role as a tumour suppressor is controversial, an issue complicated by the existence of two classes of p63 isoforms...
- p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosisJames W Rocco
Massachusetts General Hospital Center for Cancer Research and Harvard Medical School, Boston, Massachusetts 02114, USA
Cancer Cell 9:45-56. 2006..Inhibition of endogenous p63 expression by RNAi induces apoptosis selectively in HNSCC cells that overexpress deltaNp63alpha...
- p63 expression profiles in human normal and tumor tissuesCharles J Di Como
Division of Molecular Pathology, Department of Pathology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Clin Cancer Res 8:494-501. 2002The p63 gene, located on chromosome 3q27-28, is a member of the p53 gene family. The product encoded by the p63 gene has been reported to be essential for normal development.
- The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancersChee Onn Leong
Massachusetts General Hospital Cancer Center and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
J Clin Invest 117:1370-80. 2007..Here we demonstrated that the p53 family member p63 controls a pathway for p73-dependent cisplatin sensitivity specific to these "triple-negative" tumors...
- Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndromeJ Celli
Department of Human Genetics 417, University Hospital Nijmegen, The Netherlands
Cell 99:143-53. 1999..Analysis of the p63 gene, a homolog of p53 located in the critical LMS/EEC interval, revealed heterozygous mutations in nine unrelated ..
- p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53G Melino
Medical Research Council, Toxicology Unit, Hodgkin Building, Leicester University, Leicester, UK
Cell Death Differ 18:1487-99. 2011..This effect seems mediated at least partially by its ability to physically interact with p63, thus affecting a cell invasion pathway, and accordingly, p63 is deregulated in human cancers...
- A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancerLambertus A Kiemeney
Department of Epidemiology, Biostatistics and Health Technology Assessment, Nijmegen, The Netherlands
Nat Genet 42:415-9. 2010..The frequency of rs798766[T] is higher in Ta tumors that carry an activating mutation in FGFR3 than in Ta tumors with wild-type FGFR3. Our results show a link between germline variants, somatic mutations of FGFR3 and risk of UBC...
- p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activitiesA Yang
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cell 2:305-16. 1998We describe the cloning of p63, a gene at chromosome 3q27-29 that bears strong homology to the tumor suppressor p53 and to the related gene, p73...
- Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladderFumitaka Koga
Department of Urology and Reproductive Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Clin Cancer Res 9:5501-7. 2003b>p63 is proposed to play roles in normal development and differentiation of stratified epithelia including urothelium...
- Split-hand/split-foot malformation is caused by mutations in the p63 gene on 3q27P Ianakiev
Department of Pediatrics, University of Connecticut Health Center, Farmington 06030, USA
Am J Hum Genet 67:59-66. 2000..Results of gene-targeting studies have demonstrated that p63, a homologue of the cell-cycle regulator TP53, plays a critically important role in regulation of the formation and ..
- TP63 gene mutation in ADULT syndromeJ Amiel
Département de génétique, et Unité INSERM U 393, Hopital Necker Enfants Malades, 149, rue de Sevres, 75743 Paris Cedex 15, France
Eur J Hum Genet 9:642-5. 2001..with ectrodactyly as a major feature, have been mapped to chromosome 3q27 close by the TP63 locus, namely the LMS and ADULT syndromes. Here, we report on a missense TP63 gene mutation in an isolated ADULT syndrome case...
- Distinct expression profiles of p63 variants during urothelial development and bladder cancer progressionOrit Karni-Schmidt
Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA
Am J Pathol 178:1350-60. 2011..The lack of p63 isoform-specific antibodies has limited the analysis of the biological significance of p63...
- Genome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivoAnnie Yang
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
PLoS ONE 5:e11572. 2010The p53 homologs, p63 and p73, share approximately 85% amino acid identity in their DNA-binding domains, but they have distinct biological functions.
- Regulation of p53 family member isoform DeltaNp63alpha by the nuclear factor-kappaB targeting kinase IkappaB kinase betaAditi Chatterjee
Division of Head and Neck Cancer Research, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Cancer Res 70:1419-29. 2010The p53 family gene p63 plays an instrumental role in cellular stress responses including responses to DNA damage...
- p63 in laryngeal squamous cell carcinoma: evidence for a role of TA-p63 down-regulation in tumorigenesis and lack of prognostic implications of p63 immunoreactivityGiancarlo Pruneri
Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
Lab Invest 82:1327-34. 2002b>p63 is a p53-related gene that encodes for multiple mRNA transcripts with (TA-p63) or without (DeltaN-p63) transactivating properties on p53-responsive genes...
- Structural evolution of p53, p63, and p73: implication for heterotetramer formationAndreas C Joerger
Centre for Protein Engineering, Medical Research Council, Hills Road, Cambridge CB2 0QH, United Kingdom
Proc Natl Acad Sci U S A 106:17705-10. 2009Oligomerization of members of the p53 family of transcription factors (p53, p63, and p73) is essential for their distinct functions in cell-cycle control and development...
- p63 Gene mutations in eec syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype-phenotype correlationH van Bokhoven
Department of Human Genetics, University Medical Centre, Nijmegen, The Netherlands
Am J Hum Genet 69:481-92. 2001b>p63 mutations have been associated with EEC syndrome (ectrodactyly, ectodermal dysplasia, and cleft lip/palate), as well as with nonsyndromic split hand-split foot malformation (SHFM)...
- A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanismZach Serber
Graduate Group in Biophysics, University of California San Francisco, San Francisco, California 94143, USA
Mol Cell Biol 22:8601-11. 2002..The p53 homologue p63, for example, is a tetrameric transcription factor implicated in epithelial development and expressed as at least ..
- The p53 homologue DeltaNp63alpha interacts with the nuclear factor-kappaB pathway to modulate epithelial cell growthKathryn E King
Division of Monoclonal Antibodies, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Cancer Res 68:5122-31. 2008..This is the first report indicating that high levels of DeltaNp63alpha interact with activated c-Rel in keratinocytes and SCC, thereby promoting uncontrolled proliferation, a key alteration in the pathogenesis of cancers...
- TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondriaOlav Gressner
Department of Internal Medicine IV, Hepatology and Gastroenterology, University Hospital, Heidelberg, Germany
EMBO J 24:2458-71. 2005TP63, an important epithelial developmental gene, has significant homology to p53. Unlike p53, the expression of p63 is regulated by two different promoters resulting in proteins with opposite functions: the full-length transcriptionally ..
- DeltaNp63 expression is associated with poor survival in ovarian cancerS Marchini
Laboratory of Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Ann Oncol 19:501-7. 2008b>P63 belongs to the 'p53 family' whose role in cancer progression has been recently revisited in light of the plethora of splicing variants that are generated...
- The promyelocytic leukaemia protein tumour suppressor functions as a transcriptional regulator of p63Francesca Bernassola
Department of Pathology, Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Oncogene 24:6982-6. 2005b>p63 plays unique developmental roles in epidermal morphogenesis, despite its structural similarity with p53...
- The Role of p63 and p73 in tumor formation and progression: coming of age toward clinical usefulness. Commentary re: F. Koga et al., Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of thUte M Moll
Department of Pathology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
Clin Cancer Res 9:5437-41. 2003
- p63 maintains keratinocyte proliferative capacity through regulation of Skp2-p130 levelsSimon S McDade
Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen s University Belfast, Belfast BT9 7BL, UK
J Cell Sci 124:1635-43. 2011b>p63 is a master regulator of proliferation and differentiation in stratifying epithelia, and its expression is frequently altered in carcinogenesis. However, its role in maintaining proliferative capacity remains unclear...
- Differential altered stability and transcriptional activity of ΔNp63 mutants in distinct ectodermal dysplasiasGareth Browne
Medical Research Council, Leicester University, Leicester LE19HN, UK
J Cell Sci 124:2200-7. 2011Heterozygous mutations of p63, a key transcription factor in epithelial development, are causative in a variety of human ectodermal dysplasia disorders...
- A new E6/P63 pathway, together with a strong E7/E2F mitotic pathway, modulates the transcriptome in cervical cancer cellsSebastien Teissier
Unité Expression Génétique et Maladies, CNRS FRE 2850, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
J Virol 81:9368-76. 2007..study, using new high-density microarrays containing more than 22,000 human cDNA sequences, we identified a novel p63 pathway among E2-activated genes and 38 new mitotic genes repressed by E2...
- TAp63 regulates VLA-4 expression and chronic lymphocytic leukemia cell migration to the bone marrow in a CD74-dependent mannerInbal Binsky
Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
J Immunol 184:4761-9. 2010..These results could form the basis of novel therapeutic strategies aimed at blocking homing of CLL cells in their return to the BM and attenuating their survival...
- Spectrum of p63 mutations in a selected patient cohort affected with ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (AEC)Tuula Rinne
Department of Human Genetics, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands
Am J Med Genet A 149:1948-51. 2009Heterozygous mutations in the p63 gene underlie a group of at least seven allelic syndromes, including ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (AEC) and Rapp Hodgkin syndrome (RHS), which involves varying degrees of ..
- YAP dysregulation by phosphorylation or ΔNp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsetsR Ehsanian
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892 1419, USA
Oncogene 29:6160-71. 2010..AKT and/or ΔNp63 are potential targets for enhancing YAP-mediated apoptosis and chemosensitivity in HNSCCs...
- DeltaNp63alpha repression of the Notch1 gene supports the proliferative capacity of normal human keratinocytes and cervical cancer cellsTakashi Yugawa
Virology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo, Japan
Cancer Res 70:4034-44. 2010The p53 family member p63 is a master regulator of epithelial development...
- Immunohistochemical expression of p63, p53 and MIB-1 in urinary bladder carcinoma. A tissue microarray study of 158 casesEva Comperat
Service Central d Anatomie et Cytologie Pathologiques et d Urologie, hôpital La Pitié Salpêtrière, 83, Bd de l Hopital, 75013 Paris, France
Virchows Arch 448:319-24. 2006b>P63 is a member of the p53 family, which plays a role in the differentiation of urothelium and is supposed to play a role in urothelial carcinogenesis...
- Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6Sanjay Mukhopadhyay
Department of Pathology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
Am J Surg Pathol 35:15-25. 2011..biopsies and resections were stained with CK7, TTF-1, napsin A (novel aspartic proteinase of the pepsin family), p63, CK5/6, and 34βE12...
- Yes-associated protein 1 regulates the stability of DeltaNp63alphaAditi Chatterjee
Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Cell Cycle 9:162-7. 2010..Thus, our results strongly suggest that Yap1 plays a role in the regulation of endogenous DeltaNp63alpha levels and is likely to contribute to the regulation of DeltaNp63alpha, in physiological conditions...
- DeltaNp63alpha promotes apoptosis of human epidermal keratinocytesLing Zhu
Department of Physiology and Biophysics, Case School of Medicine, Cleveland, Ohio, USA
J Invest Dermatol 127:1980-91. 2007..Both deltaNp63alpha and TAp63alpha reduce SCC-13 cell survival. These studies indicate that both deltaNp63alpha and TAp63alpha can negatively regulate keratinocyte survival...
- DNA-binding and transactivation activities are essential for TAp63 protein degradationHaoqiang Ying
Department of Biochemistry, Boston University School of Medicine, K423, 715 Albany St, Boston, Massachusetts 02118, USA
Mol Cell Biol 25:6154-64. 2005The p53-related p63 gene encodes six isoforms with differing N and C termini. TAp63 isoforms possess a transactivation domain at the N terminus and are able to transactivate a set of genes, including some targets downstream of p53...
- WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosisY Li
Center for Cell Biology and Cancer Research, MS355, Albany Medical College, Albany, NY 12208, USA
Cell Death Differ 15:1941-51. 2008..However, the mechanism of WWP1 action is still largely unknown. p63, a member of the p53 family of transcription factors, has an important function in tumor development by regulating ..
- Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinomaMaurice Phillip DeYoung
Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
Cancer Res 66:9362-8. 2006b>p63 is essential for normal epithelial development and is overexpressed in the vast majority of squamous cell carcinomas (SCC)...
- The E3 ubiquitin ligase Itch controls the protein stability of p63Mario Rossi
Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, United Kingdom
Proc Natl Acad Sci U S A 103:12753-8. 2006b>p63, a member of the p53 family of transcription factors, plays an important role in epithelial development, regulating both cell cycle and apoptosis...
- Loss of p63 expression is associated with tumor progression in bladder cancerMarshall J Urist
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Am J Pathol 161:1199-206. 2002b>p63, a member of the p53 gene family, encodes multiple proteins that may either transactivate p53 responsive genes (TAp63) or act as a dominant-negative factor toward p53 and p73 (Delta Np63)...
- Gain-of-function mutation in ADULT syndrome reveals the presence of a second transactivation domain in p63Pascal H G Duijf
Department of Human Genetics 417, University Medical Centre Nijmegen, Box 9101, 6500 HB Nijmegen, The Netherlands
Hum Mol Genet 11:799-804. 2002The transcriptional co-activator p63 is of crucial importance for correct development of the limbs, ectodermal appendages (skin, nails, teeth, hair, glands), lip and palate...
- Novel in vivo targets of DeltaNp63 in keratinocytes identified by a modified chromatin immunoprecipitation approachBarbara Birkaya
Department of Biochemistry, State University of New York at Buffalo, Buffalo, NY 14214, USA
BMC Mol Biol 8:43. 2007b>p63 is a transcription factor that plays an important role in skin epidermal development and differentiation...
- Mutational analysis of the p63/p73L/p51/p40/CUSP/KET gene in human cancer cell lines using intronic primersK Hagiwara
Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Cancer Res 59:4165-9. 1999..identification of p73, a second homologue of the human p53 tumor suppressor gene has been reported and named p63/p73L/p51/p40/CUSP/KET...
- p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53T S Davison
Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada
J Biol Chem 274:18709-14. 1999..Here we report in vitro and in vivo analysis of homo- and hetero-oligomerization of p53 and its homologues, p63 and p73...
- p53 and Delta Np63 alpha differentially bind and regulate target genes involved in cell cycle arrest, DNA repair and apoptosisK L Schavolt
Department of Biochemistry, Center for Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA
Oncogene 26:6125-32. 2007....
- Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63J A McGrath
Department of Cell and Molecular Pathology, St John s Institute of Dermatology, The Guy s, King s College and St Thomas Hospitals Medical School, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
Hum Mol Genet 10:221-9. 2001..We have recently demonstrated that heterozygous mutations in the p63 gene are the major cause of EEC syndrome...
- DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and developmentGuojun Wu
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
Cancer Res 63:2351-7. 2003The p63 gene shows remarkable structural similarity to the p53 and p73 genes. Because of two promoters, the p63 gene generates two types of protein isoforms, TAp63 and DeltaNp63...
- Connecting p63 to cellular proliferation: the example of the adenosine deaminase target geneElisabetta Sbisà
Istituto Tecnologie Biomediche CNR Sede di Bari di Bioinformatica e Genomica, Bari, Italy
Cell Cycle 5:205-12. 2006An unresolved issue regards the role of p73 and p63, the two homologs of the p53 oncosuppressor gene, in normal cells and in tumor development...
- SSRP1 functions as a co-activator of the transcriptional activator p63Shelya X Zeng
Department of Biochemistry and Molecular Biology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
EMBO J 21:5487-97. 2002The p53 homolog p63 is a transcriptional activator. Here, we describe the identification of an HMG1-like protein SSRP1 as a co-activator of p63...
- p300 regulates p63 transcriptional activityMary MacPartlin
Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon 97239, USA
J Biol Chem 280:30604-10. 2005..Here we describe a study showing that this coactivator also regulates the transcriptional function of p63. p300 bound to the N-terminal domain of p63gamma, and p63gamma bound to the N terminus of p300 in vitro and in ..
- The protein stability and transcriptional activity of p63alpha are regulated by SUMO-1 conjugationPamela Ghioni
Department of Biomolecular and Biotechnological Sciences, University of Milan, Milan, Italy
Cell Cycle 4:183-90. 2005..Four natural p63 mutations, falling within the SAM and post-SAM domain of p63alpha, were found to be altered in their sumoylation ..
- TAp63gamma can substitute for p53 in inducing expression of the maspin tumor suppressorKatja Spiesbach
Department of Internal Medicine II, University of Leipzig, Leipzig, Germany
Int J Cancer 114:555-62. 2005..Maspin gene expression can be upregulated by the tumor suppressor p53. We tested 7 p53-related proteins of the p63 and p73 families for their ability to induce maspin expression...
- ASPP1 and ASPP2: common activators of p53 family membersDaniele Bergamaschi
Ludwig Institute for Cancer Research, Imperial College School of Medicine, St Mary s Campus, London W2 1PG, United Kingdom
Mol Cell Biol 24:1341-50. 2004..We show here that ASPP1 and ASPP2 also induce apoptosis independently of p53. By binding to p63 and p73 in vitro and in vivo, ASPP1 and ASPP2 stimulate the transactivation function of p63 and p73 on the ..
- Phospho-DeltaNp63alpha/NF-Y protein complex transcriptionally regulates DDIT3 expression in squamous cell carcinoma cells upon cisplatin exposureYiping Huang
Department of Dermatology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Cell Cycle 9:328-38. 2010....
- The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutationsMatthew D Westfall
Department of Biochemistry, Center in Molecular Toxicology, The Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Mol Cell Biol 23:2264-76. 2003b>p63 is a recently identified homolog of p53 that is found in the basal layer of several stratified epithelial tissues such as the epidermis, oral mucosa, prostate, and urogenital tract...
- Mutations in the p53 homolog p63: allele-specific developmental syndromes in humansHans van Bokhoven
Dept of Human Genetics, University Medical Center Nijmegen, The Netherlands
Trends Mol Med 8:133-9. 2002b>p63 is the most recently discovered but most ancient member of the p53 family. In marked contrast to p53, p63 is highly expressed in embryonic ectoderm and in the basal, regenerative layers of many epithelial tissues in the adult...
- The unique NH2-terminally deleted (DeltaN) residues, the PXXP motif, and the PPXY motif are required for the transcriptional activity of the DeltaN variant of p63E Scott Helton
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
J Biol Chem 281:2533-42. 2006b>p63, a member of the p53 family of transcription factors, is known to be involved in epithelial development. However, its role in tumorigenesis is unclear...
- Properties of the six isoforms of p63: p53-like regulation in response to genotoxic stress and cross talk with DeltaNp73A Petitjean
INSERM UMR590, Unité d Oncogenèse et de Progression Tumorale, Centre Leon Berard, 28 rue Laennec, F69008 Lyon, France
Carcinogenesis 29:273-81. 2008..role of these isoforms and to better understand their functional overlap with p53, we ectopically expressed each p63 isoform in the p53-null hepatocellular carcinoma cell line Hep3B...
- Identification of new p63 targets in human keratinocytesBarbara Testoni
Dipartimento di Scienze Biomolecolari e Biotecnologie, U di Milano, Milano, Italy
Cell Cycle 5:2805-11. 2006b>p63 is a transcription factor involved in the development of ectodermal tissues, including limb, skin and, in general, multilayered epithelia...
- A functional enhancer of keratin14 is a direct transcriptional target of deltaNp63Rose Anne Romano
Department of Biochemistry, State University of New York at Buffalo, Buffalo, New York 14214, USA
J Invest Dermatol 127:1175-86. 2007..Finally, we show that ectopic expression of either p63 isoform (deltaN or TA) can induce de novo expression of K14...
- Correlation of p63 immunoreactivity with tumor grade in meningiomasElisabeth J Rushing
Department of Neuropathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
Int J Surg Pathol 16:38-42. 2008..The present study was undertaken to assess the correlation between p63 expression and histological grade of meningiomas...
- Differential recognition of response elements determines target gene specificity for p53 and p63Motonobu Osada
Department of Otolaryngology, Division of Head and Neck Surgery, Johns Hopkins University School of Medicine, 818 Ross Research Building, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
Mol Cell Biol 25:6077-89. 2005b>p63 is a member of the p53 tumor suppressor gene family, which regulates downstream target gene expression by binding to sequence-specific response elements similar to those of p53...
- [Expression of GLUT-1, p63 and DNA-Pkcs in serous ovarian tumors and their significance]Shu Li Shao
Department of Gynecology, Tumor Hospital of Shanxi Province, Taiyuan 030013, China
Zhonghua Zhong Liu Za Zhi 29:697-700. 2007To investigate the expression of GLUT1, p63 and DNA-Pkcs in serous ovarian tumors and their significance.
- p63 regulates an adhesion programme and cell survival in epithelial cellsDanielle K Carroll
Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
Nat Cell Biol 8:551-61. 2006b>p63 is critical for epithelial development yet little is known about the transcriptional programmes it regulates...
- Cross-regulation between Notch and p63 in keratinocyte commitment to differentiationBach Cuc Nguyen
Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA, and Department of Biochemistry, University of Lausanne, Switzerland
Genes Dev 20:1028-42. 2006Notch signaling promotes commitment of keratinocytes to differentiation and suppresses tumorigenesis. p63, a p53 family member, has been implicated in establishment of the keratinocyte cell fate and/or maintenance of epithelial self-..
- Dual regulation of the DeltaNp63 transcriptional activity by DeltaNp63 in human nasopharyngeal carcinoma cellWing Keung Chu
Department of Physiology, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Biochem Biophys Res Commun 342:1356-60. 2006b>p63 splicing variants lacking NH(2)-terminal transactivating domain, known as DeltaNp63, are thought to antagonize p53 and p63 functions and are suggested to play roles in keratinocyte differentiation...
- GPX2, a direct target of p63, inhibits oxidative stress-induced apoptosis in a p53-dependent mannerWensheng Yan
Department of Cell Biology, The University of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
J Biol Chem 281:7856-62. 2006The p53 family consists of p53, p63, and p73, each of which has multiple isoforms due to transcription at two separate promoters and alternative splicing...
- Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cellsAnnie Yang
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cell 24:593-602. 2006Using tiled microarrays covering the entire human genome, we identify approximately 5800 target sites for p63, a p53 homolog essential for stratified epithelial development...
- miR-203 represses 'stemness' by repressing DeltaNp63A M Lena
Biochemistry Laboratory IDI IRCCS and University of Rome Tor Vergata, Department of Experimental Medicine and Biochemical Sciences, Rome, Italy
Cell Death Differ 15:1187-95. 2008..The epidermis develops depending on the transcription factor p63, a member of the p53 family of transcription factors...
- Utility of WT-1, p63, MOC31, mesothelin, and cytokeratin (K903 and CK5/6) immunostains in differentiating adenocarcinoma, squamous cell carcinoma, and malignant mesothelioma in effusionsRobert T Pu
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Diagn Cytopathol 36:20-5. 2008..This study evaluates the utility of WT-1, p63, MOC31, mesothelin, and cytokeratin (K903 and CK5/6) immunostains in effusions when ADC and SCC of the lung are in ..
- ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damageYiping Huang
Department of Dermatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Cell Cycle 7:2846-55. 2008..Our results implicate specific kinases, and target phosphorylation sites in the degradation of Delta Np63 alpha following DNA damage...
- p63 and epithelial biologyChristopher E Barbieri
Department of Biochemistry, Center in Molecular Toxicology, 652 Preston Research Building, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Exp Cell Res 312:695-706. 2006The transcription factor p63 is a homologue of the tumor suppressor p53...
- Antibodies targeting p63 react specifically in the cytoplasm of breast epithelial cells exhibiting secretory differentiationG L Bratthauer
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington DC 20306, USA
Histopathology 47:611-6. 2005The nuclear detection of p63 in myoepithelial cells of the breast has been useful in identifying possibly invasive carcinomas...
- Reciprocal regulation of p63 by C/EBP delta in human keratinocytesSerena Borrelli
Dipartimento di Scienze Biomolecolari e Biotecnologie, U, di Milano, Via Celoria 26, 20133 Milano, Italy
BMC Mol Biol 8:85. 2007Genetic experiments have clarified that p63 is a key transcription factor governing the establishment and maintenance of multilayered epithelia. Key to our understanding of p63 strategy is the identification of target genes...
- Physical interaction between Wilms tumor 1 and p73 proteins modulates their functionsV Scharnhorst
Laboratory of Molecular Carcinogenesis and Centre for Biomedical Genetics, Leiden University Medical Center, P O Box 9503, 2300 RA Leiden, The Netherlands
J Biol Chem 275:10202-11. 2000..This, taken together with our finding that WT1 also interacts with p63/KET, another p53 homologue, suggests that association between WT1 and the members of the p53 family of proteins may ..
- p63 expression in normal skin and usual cutaneous carcinomasJorge S Reis-Filho
IPATIMUP, Institute of Molecular Pathology and Immunology, University of Porto, Portugal
J Cutan Pathol 29:517-23. 2002b>p63 is a p53 homologue that is mapped to chromosome 3q27. This gene encodes six different isoforms, which have either transactivating or dominant negative effects on p53-reporter genes...
- Cloning and functional analysis of human p51, which structurally and functionally resembles p53M Osada
Department of Cell Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
Nat Med 4:839-43. 1998..9 kDa. In contrast with the ubiquitous expression of p53, expression of p51 mRNA was found in a limited number of tissues, including skeletal muscle, placenta, mammary gland, prostate, ..
- DeltaNp63 induces beta-catenin nuclear accumulation and signalingMeera Patturajan
Department of Otolaryngology Head and Neck Surgery, John Hopkins School of Medicine, Baltimore, MD 21205, USA
Cancer Cell 1:369-79. 2002The P53 homolog p63 encodes multiple proteins with transactivating, apoptosis-inducing, and oncogenic activities...
- AIS is an oncogene amplified in squamous cell carcinomaK Hibi
Department of Otolaryngology Head and Neck Surgery, Division of Head and Neck Cancer Research, Johns Hopkins University School of Medicine, 818 Ross Research Building, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
Proc Natl Acad Sci U S A 97:5462-7. 2000..We named this locus AIS for amplified in squamous cell carcinoma.) Furthermore, amplification of the AIS locus was accompanied by RNA and protein overexpression of ..
- p63 and p73 are required for p53-dependent apoptosis in response to DNA damageElsa R Flores
Massachusetts Institute of Technology, Department of Biology and Center for Cancer Research, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
Nature 416:560-4. 2002..Although the p53 family members p63 and p73 are structurally related to p53, they have not been directly linked to tumour suppression, although they ..
- The p53 family member genes are involved in the Notch signal pathwayYasushi Sasaki
Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, S 1, W 17, Chuo Ku, Sapporo, 060 8556 Japan
J Biol Chem 277:719-24. 2002..b>p63/p51 and p73 were recently identified as members of the p53 gene family...
- Cloning and chromosomal mapping of the human p53-related KET gene to chromosome 3q27 and its murine homolog Ket to mouse chromosome 16M Augustin
Fraunhofer Institute of Toxicology and Aerosol Research, Center for Medical Biotechnology and Department of Cell Biology, Nikolai Fuchs Str 1, D 30625 Hannover, Germany
Mamm Genome 9:899-902. 1998b>KET is a member of the newly discovered family of proteins that is related to the tumor suppressor p53. Here we describe the molecular cloning of a human cDNA of 4846 bp encoding a protein of 680 amino acids...
- Differential expression of p53 gene family members p63 and p73 in head and neck squamous tumorigenesisHong Ran Choi
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Hum Pathol 33:158-64. 2002p73 and p63 are recently cloned genes that share considerable structural and functional homologies with the p53 tumor suppressor gene...
- Isoforms of DeltaNp63 and the migration of ocular limbal cells in human corneal regenerationEnzo Di Iorio
Epithelial Stem Cell Research Center, Veneto Eye Bank Foundation, 30122 Venice, Italy
Proc Natl Acad Sci U S A 102:9523-8. 2005The p63 gene generates transactivating and N-terminally truncated transcripts (DeltaNp63) initiated by different promoters. Alternative splicing gives rise to three different C termini, designated alpha, beta, and gamma...
- Abnormalities of sex differentiationH Nawata
Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
Horm Res 46:15-9. 1996..Androgen insensitivity syndrome (AIS) is a good model to clarify the relationship between the structure and function of androgen receptor, the androgen ..
- Risk assessment of inhaled chloroform based on its mode of actionD C Wolf
Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 25:49-52. 1997..When information to the contrary is not available, the linearized multistage (LMS) model, a conservative model that assumes some risk of cancer at any dose, is traditionally employed...
- Prospective pulmonary function evaluation following open thoracotomy for anterior spinal fusion in adolescent idiopathic scoliosisE J Graham
Washington University, Department of Orthopaedic Surgery, St Louis, MO, USA
Spine (Phila Pa 1976) 25:2319-25. 2000..PFTs) at a minimum 2-year follow-up after an open anterior spinal fusion (ASF) with instrumentation for thoracic AIS. SUMMARY OF BACKGROUND DATA: Anterior spinal fusion with instrumentation is currently undergoing evaluation as an ..
- The Ste-Justine Adolescent Idiopathic Scoliosis Cohort Study. Part II: Perception of health, self and body image, and participation in physical activitiesM S Goldberg
Occupational and Environmental Health Section, Montreal Public Health Department, Quebec
Spine (Phila Pa 1976) 19:1562-72. 1994OBJECTIVES. This study determined the health and well being of persons with adolescent idiopathic scoliosis (AIS) more than 10 years after referral...
- The use of p63 as an effective immunomarker in the diagnosis of pulmonary squamous cell carcinomas on de-stained bronchial lavage cytological smearsM Uke
Division of Cytology, Tata Memorial Hospital, Mumbai, India
Cytopathology 21:56-63. 2010..Lately, p63 antibody has been used for distinguishing squamous cell carcinoma from SCLC and adenocarcinoma...
- Is atmospheric superoxide vitally necessary? Accelerated death of animals in a quasi-neutral electric atmosphereN Goldstein
Goldstein and Lewin Technology GmbH, Dept of Medical Research, Stahnsdorf, Germany
Z Naturforsch C 52:396-404. 1997To estimate the necessity of air ions (AIs) as a natural source of atmospheric gaseous superoxide for mammalia the effect of air ion deprivation on mice and rats was investigated...
- The Ste-Justine Adolescent Idiopathic Scoliosis Cohort Study. Part IV: Surgical correction and back painB Poitras
, , Quebec
Spine (Phila Pa 1976) 19:1582-8. 1994..STUDY DESIGN. This study was designed as a comparative retrospective cohort study. Subjects referred for AIS between 1960 and 1979 to a large pediatric hospital in Montreal, Quebec, were entered into the cohort...
- Characteristics that distinguish accidental from abusive injury in hospitalized young children with head traumaKirsten Bechtel
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
Pediatrics 114:165-8. 2004..To describe the clinical features that distinguish accidental from abusive head injury in hospitalized children <24 months of age...
- Increased femoral neck-shaft angles in adolescent idiopathic scoliosisM J Saji
Duchess of Kent Children s Hospital, Sandy Bay, Hong Kong
Spine (Phila Pa 1976) 20:303-11. 1995..studies have suggested there is an association between asymmetry of the hip and lower limb and the curvature in AIS. In this study, femoral neck-shaft angle in patients with adolescent idiopathic scoliosis and in normal subjects ..
- Expression of p63 in conjunctival intraepithelial neoplasia and squamous cell carcinomaClaudia Auw-Haedrich
Eye Hospital, Albert Ludwigs University, 79106 Freiburg, Germany
Graefes Arch Clin Exp Ophthalmol 244:96-103. 2006b>p63 is a homologue of the tumour suppressor gene p53, which is expressed in human basal squamous epithelium...
- Claudin-1 is a p63 target gene with a crucial role in epithelial developmentTeresa Lopardo
Department of Biomolecular Sciences and Biotechnology, University of Milan, Milan, Italy
PLoS ONE 3:e2715. 2008..b>p63 is a transcription factor essential for proliferation of stem cells and for stratification in epithelia, mutated in ..
- Dominant negative p63 isoform expression in head and neck squamous cell carcinomaJoseph C Sniezek
Department of Otolaryngology Head and Neck Surgery, Tripler Army Medical Center, 1 Jarrett White Road, Honolulu, HI 96859 5000, USA
Laryngoscope 114:2063-72. 2004b>p63, a member of the p53 family of genes, is vital for normal epithelial development and may play a critical role in epithelial tumor formation...
- Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defectsNadia Lo Iacono
Dulbecco Telethon Institute, Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino, 10126, Italy
Development 135:1377-88. 2008..SHFM-IV and Ectrodactyly-Ectodermal dysplasia-Cleft lip (EEC) are caused by mutations in p63, an ectoderm-specific p53-related transcription factor...
- INFLAMMATORY NEUROLOGICAL DISEASESIain Campbell; Fiscal Year: 2001..Assays to be used here include analysis of p35 and p40 RNA induction, an anti-IL12 ELISA system, and a bioassay for IL12 using a human lymphoblastoid cell line generated ..
- Role of PUMA in EGFR targeted therapy in HNSCCJian Yu; Fiscal Year: 2010..Furthermore, EGFR TKIs induce PUMA through the effects on the p53 family members p63 and p73, but not p53 itself...
- P63 mediators as therapeutic targets in HNSCCLEIF ELLISEN; Fiscal Year: 2009..Cell Carcinoma (HNSCC) and related cancers, by understanding the function and regulation of the p53 family members p63 and p73. The p53 family of proteins plays a key role in the pathogenesis of HNSCC...
- P63 mediators as therapeutic targets in HNSCCLeif W Ellisen; Fiscal Year: 2010..Cell Carcinoma (HNSCC) and related cancers, by understanding the function and regulation of the p53 family members p63 and p73. The p53 family of proteins plays a key role in the pathogenesis of HNSCC...
- Mechanism of Modulation of Interleukin-12 Production by TriptolideXiaojing Ma; Fiscal Year: 2007Interleukin-12 (IL-12) is a heterodimeric cytokine composed of the p40 and p35 chains...
- THE ROLE OF P40 IN SQUAMOUS CELL CARCINOMADavid Sidransky; Fiscal Year: 2003DESCRIPTION: (Adapted from the investigator's abstract) The PI has cloned and characterized a novel p53 homolgoue p40 (AIS), one of several variants (p40/51/63/73L) that is encoded by the 3q27-28 gene locus...
- Control of Renal Glutaminase Expression during AcidosisNorman Curthoys; Fiscal Year: 2009..HuR and p40-AUF1 bind to the pHRE with high affinity and specificity...
- Control of Renal Glutaminase Expression during AcidosisNorman P Curthoys; Fiscal Year: 2010..HuR and p40-AUF1 bind to the pHRE with high affinity and specificity...
- Control of Renal Glutaminase Expression during AcidosisNorman Curthoys; Fiscal Year: 2009..HuR and p40-AUF1 bind to the pHRE with high affinity and specificity...
- ACTIVATION OF NF-KB IN GLIAL CELLS AND CNS OF EAEKalipada Pahan; Fiscal Year: 2009..We have discovered a new group of inducers of NF-kappaB activation [interleukin-12 (IL-12) p40 homodimer (p40-2) and monomer (p40)] in glial cells. It was known that p40-2 and p40 were biologically inactive...
- MOLECULAR REGULATION OF INTERLEUKIN 12 GENE EXPRESSIONXiaojing Ma; Fiscal Year: 2003..IL-12 is a heterodimer consisted to two subunits, p40 and p35 that are encoded on different human chromosomes...
- Mechanisms of action IL-23 in relapsing demyelinationAbdolmohamad Rostami; Fiscal Year: 2007Project 3. The Role of IL-23 in CNS Inflammatory DemyelinaUon. We have shown that antibodies against the p40 subunit of interleukin-12 (IL-12) prevent spontaneous and superantigen-induced relapses of experimental autoimmune ..
- Pairing of EBI-3 and IL12 p35 To Yield A Novel Regulatory T cell CytokineLAUREN COLLISON; Fiscal Year: 2007Epstein barr virus induced gene 3 (EBI-3) is a soluble protein that shares structural similarities to the IL12 p40 chain...
- Regulation of IL-12 Expression and Activity by OncogenesXiaojing Ma; Fiscal Year: 2007..The genes encoding the two heterologous chains of IL-12, p40 and p35 are located on different chromosomes. Together, p40 and p35 form the biologically active IL-12...
- Clinically relevant molecular subtypes in leiomyosarcomaJAN MATT VAN DE RIJN; Fiscal Year: 2010The current treatment of leiomyosarcoma (LMS), the most common form of sarcoma, involves ineffective systemic therapy that is based on a trial and error approach and on the assumption that tumors called "LMS" form a homogenous group...
- NNRTI induced conformational changes in HIV-1 Reverse TranscriptaseNicolas Sluis Cremer; Fiscal Year: 2007..RT) is a heterodimeric enzyme consisting of a 66-kDa subunit (termed p66) and a p66- derived 51-kDa subunit (p51)...
- Cytoplasmic Reactivation of p53 Family MembersCharles Walker; Fiscal Year: 2004..leukemia in the soft-shell clam, Mya arenaria, in which clam homologs that we have identified for human p53 and p63/73 proteins are rendered non-functional by their sequestration in the cytoplasm of leukemic clam hemocytes...
- P63/IGFBP3/BCL2 Control of Corneal Epithelial HomeostasisDANIELLE ROBERTSON; Fiscal Year: 2009....
- P63/IGFBP3/BCL2 Control of Corneal Epithelial HomeostasisDanielle M Robertson; Fiscal Year: 2010....
- Characterization of the Desmosome Protein PerpLaura D Attardi; Fiscal Year: 2010..Using knockout mice, we recently identified the Perp tetraspan membrane protein as a component of the p63 stratified epithelial development program, where it plays an essential role in desmosome function and epithelial ..
- Mechanisms regulating prostate epithelium maintenance and regenerationSabina Signoretti; Fiscal Year: 2010..The p63 gene is selectively expressed in basal cells of various epithelia and is required for epithelial development...
- Characterization of the Desmosome Protein PerpLAURA ATTARDI; Fiscal Year: 2007..Using knockout mice, we recently identified the Perp tetraspan membrane protein as a component of the p63 stratified epithelial development program, where it plays an essential role in desmosome function and epithelial ..
- Probiotics-derived soluble proteins regulate intestinal inflammationFang Yan; Fiscal Year: 2010..We have successfully purified and cloned two novel LGG-derived soluble proteins (p40 and p75) that prevent cytokine-induced apoptosis through activating Akt in intestinal epithelial cells...
- BABOON RESEARCH RESOURCE PROGRAMGary White; Fiscal Year: 2007This P40 competitive renewal proposes to continue the aims of the initial grant application and expand the support of research investigators using baboons as models in biomedical and behavioral research...
- Viper Resource Center (VRC) at Texas A&M University-KingsvilleJohn Perez; Fiscal Year: 2009The Viper Resource Center (VRC), P40 competitive renewal, at Texas A&M University-Kingsville proposes to continue the aims of the initial grant application...
- Viper Resource Center (VRC) at Texas A&M University-KingsvilleJOHN CARLOS PEREZ; Fiscal Year: 2010The Viper Resource Center (VRC), P40 competitive renewal, at Texas A&M University-Kingsville proposes to continue the aims of the initial grant application...
- Viper Resource Center (VRC) at Texas A&M University-KingsvilleJohn Perez; Fiscal Year: 2009The Viper Resource Center (VRC), P40 competitive renewal, at Texas A&M University-Kingsville proposes to continue the aims of the initial grant application...
- Oxytocin, Postnatal Experience & Adult Maternal BehaviorCort Pedersen; Fiscal Year: 2006..In Preliminary Studies, rat dams subjected to brief and long daily maternal separations (BMS vs. LMS) during infancy exhibited, respectively, increased and decreased pup-grooming (PG), maternal aggression and ..
- ROLE OF IL-23 IN PSORIASIS PATHOGENESISAndrew Blauvelt; Fiscal Year: 2007..IL-23, a recently discovered cytokine that consists of p19 and p40 subunits, is now believed to be critical in the development of several classic autoimmune inflammatory diseases in ..
- REGULATION AND FUNCTION OF KERATINS IN THE EPIDERMISDENNIS ROOP; Fiscal Year: 2010..We have recently demonstrated that the transcription factor p63 is the molecular switch for initiation of the epidermal stratification program...
- IRON UPTAKE AS A VIRULENCE FACTOR IN PATHOGENIC VIBRIOSJORGE CROSA; Fiscal Year: 1993..characterized the essential components of this system: the siderophore anguibactin; the transport proteins OM2 and P40, and regulatory elements controlling their biosynthesis...
- The role of p63 in normal epidermal differentiation and ectodermal dysplasiasMARANKE KOSTER; Fiscal Year: 2007Project Summary: Dominant mutations in p63, a transcription factor expressed as six isoforms, underlie the skin fragility syndrome ankyloblepharon ectodermal dysplasia and clefting (AEC)...