p57Kip2

Summary

Gene Symbol: p57Kip2
Description: cyclin dependent kinase inhibitor 1C
Alias: BWCR, BWS, KIP2, WBS, p57, p57Kip2, cyclin-dependent kinase inhibitor 1C, cyclin-dependent kinase inhibitor 1C (p57, Kip2), cyclin-dependent kinase inhibitor p57
Species: human
Products:     p57Kip2

Top Publications

  1. Matsuoka S, Thompson J, Edwards M, Bartletta J, Grundy P, Kalikin L, et al. Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15. Proc Natl Acad Sci U S A. 1996;93:3026-30 pubmed
    ..The gene encoding cyclin-dependent kinase inhibitor p57KIP2, whose overexpression causes G1 phase arrest, was recently cloned and mapped to this band...
  2. Diaz Meyer N, Day C, Khatod K, Maher E, Cooper W, Reik W, et al. Silencing of CDKN1C (p57KIP2) is associated with hypomethylation at KvDMR1 in Beckwith-Wiedemann syndrome. J Med Genet. 2003;40:797-801 pubmed
    Beckwith-Wiedemann syndrome (BWS) arises by several genetic and epigenetic mechanisms affecting the balance of imprinted gene expression in chromosome 11p15.5...
  3. Borriello A, Caldarelli I, Bencivenga D, Criscuolo M, Cucciolla V, Tramontano A, et al. p57(Kip2) and cancer: time for a critical appraisal. Mol Cancer Res. 2011;9:1269-84 pubmed publisher
    p57(Kip2) is a cyclin-dependent kinase inhibitor belonging to the Cip/Kip family, which also includes p21(Cip1) and p27(Kip1)...
  4. Hatada I, Ohashi H, Fukushima Y, Kaneko Y, Inoue M, Komoto Y, et al. An imprinted gene p57KIP2 is mutated in Beckwith-Wiedemann syndrome. Nat Genet. 1996;14:171-3 pubmed
    b>p57KIP2 is a potent tight-binding inhibitor of several G1 cyclin/Cdk complexes, and is a negative regulator of cell proliferation. The gene encoding p57KIP2 is located at 11p15.5 (ref...
  5. Chow S, Wang J, Lin M, Lee C. Downregulation of p57kip² promotes cell invasion via LIMK/cofilin pathway in human nasopharyngeal carcinoma cells. J Cell Biochem. 2011;112:3459-68 pubmed publisher
    ..p57(kip2) , a CDK inhibitor, is frequently down-regulated in several malignancy tumors...
  6. Merlo P, Fulco M, Costanzo A, Mangiacasale R, Strano S, Blandino G, et al. A role of p73 in mitotic exit. J Biol Chem. 2005;280:30354-60 pubmed
    ..We also found that the cyclin-dependent kinase inhibitor Kip2/p57 gene is a specific target of p73 regulation during mitotic exit and re-entry into G1...
  7. Vlachos P, Joseph B. The Cdk inhibitor p57(Kip2) controls LIM-kinase 1 activity and regulates actin cytoskeleton dynamics. Oncogene. 2009;28:4175-88 pubmed publisher
    The cyclin-dependent kinase inhibitor p57(Kip2) gene has been suggested to be a tumor suppressor gene, being inactivated in various cancer types, linked to tumor progression and poor patient outcome...
  8. Kuang S, Ling X, Sanchez Gonzalez B, Yang H, Andreeff M, Garcia Manero G. Differential tumor suppressor properties and transforming growth factor-beta responsiveness of p57KIP2 in leukemia cells with aberrant p57KIP2 promoter DNA methylation. Oncogene. 2007;26:1439-48 pubmed
    To investigate if the tumor suppressor properties of p57KIP2 are dependent on its DNA methylation status, we studied the impact of several stress stimuli in leukemic cell lines with different p57KIP2 promoter DNA methylation levels...
  9. Balint E, Phillips A, Kozlov S, Stewart C, Vousden K. Induction of p57(KIP2) expression by p73beta. Proc Natl Acad Sci U S A. 2002;99:3529-34 pubmed
    ..we describe the ability of p73beta but not p53 to activate expression of the cyclin-dependent kinase inhibitor p57(KIP) and KvLQT1, two genes that are coregulated in an imprinted region of the genome...

More Information

Publications82

  1. Joseph B, Andersson E, Vlachos P, Sodersten E, Liu L, Teixeira A, et al. p57Kip2 is a repressor of Mash1 activity and neuronal differentiation in neural stem cells. Cell Death Differ. 2009;16:1256-65 pubmed publisher
    ..Here, we show that the cyclin-dependent kinase (CDK) inhibitor p57Kip2 interacted with pro-neuronal basic helix-loop-helix (bHLH) factors such as Mash1, NeuroD, and Nex/Math2...
  2. Shen L, Toyota M, Kondo Y, Obata T, Daniel S, Pierce S, et al. Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia. Blood. 2003;101:4131-6 pubmed
    b>P57KIP2 is a cyclin-dependent kinase inhibitor silenced in a variety of human malignancies. DNA methylation of a region surrounding the transcription start site of p57KIP2 was found in acute lymphocytic leukemia (ALL)-derived cell lines...
  3. Larson P, Schlechter B, King C, Yang Q, Glass C, Mack C, et al. CDKN1C/p57kip2 is a candidate tumor suppressor gene in human breast cancer. BMC Cancer. 2008;8:68 pubmed publisher
    CDKN1C (also known as p57KIP2) is a cyclin-dependent kinase inhibitor previously implicated in several types of human cancer...
  4. Kobatake T, Yano M, Toyooka S, Tsukuda K, Dote H, Kikuchi T, et al. Aberrant methylation of p57KIP2 gene in lung and breast cancers and malignant mesotheliomas. Oncol Rep. 2004;12:1087-92 pubmed
    The p57KIP2 gene belongs to the Cip/Kip family of CDK inhibitors and has been demonstrated to be a tumor suppressor gene, being inactivated in various types of human cancers...
  5. Matsuoka S, Edwards M, Bai C, Parker S, Zhang P, Baldini A, et al. p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev. 1995;9:650-62 pubmed
    ..We describe a new CKI, p57KIP2, which is related to p21CIP1 and p27KIP1...
  6. Vlachos P, Nyman U, Hajji N, Joseph B. The cell cycle inhibitor p57(Kip2) promotes cell death via the mitochondrial apoptotic pathway. Cell Death Differ. 2007;14:1497-507 pubmed
    The p57(Kip2) gene belongs to the Cip/Kip family of cyclin-dependent kinase (CDK) inhibitors and has been suggested to be a tumor suppressor gene, being inactivated in various types of human cancers...
  7. Kim M, Nakamoto T, Nishimori S, Tanaka K, Chiba T. A new ubiquitin ligase involved in p57KIP2 proteolysis regulates osteoblast cell differentiation. EMBO Rep. 2008;9:878-84 pubmed publisher
    ..Previously, we reported that TGF-beta1 stimulation induces the degradation of p57(KIP2) in osteoblasts...
  8. Yang X, Karuturi R, Sun F, Aau M, Yu K, Shao R, et al. CDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cells. PLoS ONE. 2009;4:e5011 pubmed publisher
    CDKN1C (encoding tumor suppressor p57(KIP2)) is a cyclin-dependent kinase (CDK) inhibitor whose family members are often transcriptionally downregulated in human cancer via promoter DNA methylation...
  9. Hagiwara K, Li Y, Kinoshita T, Kunishma S, Ohashi H, Hotta T, et al. Aberrant DNA methylation of the p57KIP2 gene is a sensitive biomarker for detecting minimal residual disease in diffuse large B cell lymphoma. Leuk Res. 2010;34:50-4 pubmed publisher
    ..To resolve these problems, we applied a tumor-specific epigenetic alteration of the p57KIP2 gene as a biomarker for detecting MRD in DLBCL...
  10. Romanelli V, Belinchón A, Benito Sanz S, Martinez Glez V, Gracia Bouthelier R, Heath K, et al. CDKN1C (p57(Kip2)) analysis in Beckwith-Wiedemann syndrome (BWS) patients: Genotype-phenotype correlations, novel mutations, and polymorphisms. Am J Med Genet A. 2010;152A:1390-7 pubmed publisher
    Beckwith-Wiedemann syndrome (BWS) is an overgrowth syndrome characterized by macroglossia, macrosomia, and abdominal wall defects. It is a multigenic disorder caused in most patients by alterations in growth regulatory genes...
  11. Guo H, Lv Y, Tian T, Hu T, Wang W, Sui X, et al. Downregulation of p57 accelerates the growth and invasion of hepatocellular carcinoma. Carcinogenesis. 2011;32:1897-904 pubmed publisher
    b>p57 is a multifunctional protein involved in the regulation of tumor formation and development; however, the biological role of p57 in the pathogenesis of hepatocellular carcinoma (HCC) is poorly understood...
  12. Arboleda V, Lee H, Parnaik R, Fleming A, Banerjee A, Ferraz de Souza B, et al. Mutations in the PCNA-binding domain of CDKN1C cause IMAGe syndrome. Nat Genet. 2012;44:788-92 pubmed publisher
    ..and validation by dideoxy sequencing, identified missense mutations in the imprinted gene CDKN1C (also known as P57KIP2) in two familial and four unrelated patients...
  13. Chang T, Kim M, Ryoo K, Park J, Eom S, Shim J, et al. p57KIP2 modulates stress-activated signaling by inhibiting c-Jun NH2-terminal kinase/stress-activated protein Kinase. J Biol Chem. 2003;278:48092-8 pubmed
    b>p57KIP2, a member of the Cip/Kip family of enzymes that inhibit several cyclin-dependent kinases, plays a role in many biological events including cell proliferation, differentiation, apoptosis, tumorigenesis and developmental changes...
  14. Lam W, Hatada I, Ohishi S, Mukai T, Joyce J, Cole T, et al. Analysis of germline CDKN1C (p57KIP2) mutations in familial and sporadic Beckwith-Wiedemann syndrome (BWS) provides a novel genotype-phenotype correlation. J Med Genet. 1999;36:518-23 pubmed
    ..Recently germline mutations in the cyclin dependent kinase inhibitor gene CDKN1C (p57KIP2) have been reported in a variable minority of BWS patients...
  15. Watanabe H, Pan Z, Schreiber Agus N, DePinho R, Hurwitz J, Xiong Y. Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen. Proc Natl Acad Sci U S A. 1998;95:1392-7 pubmed
    ..The p21 family currently includes three distinct genes, p21, p27(Kip1), and p57(Kip2), that share a common N-terminal domain for binding to and inhibiting the kinase activity of CDK-cyclin complexes...
  16. Kikuchi T, Toyota M, Itoh F, Suzuki H, Obata T, Yamamoto H, et al. Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors. Oncogene. 2002;21:2741-9 pubmed
    To clarify the role of DNA methylation in the silencing of the expression of cyclin-dependent kinase inhibitor p57KIP2 seen in certain tumors, we investigated the methylation status of its 5' CpG island in various tumor cell lines and ..
  17. Li Y, Nagai H, Ohno T, Yuge M, Hatano S, Ito E, et al. Aberrant DNA methylation of p57(KIP2) gene in the promoter region in lymphoid malignancies of B-cell phenotype. Blood. 2002;100:2572-7 pubmed
    The cyclin-dependent kinase inhibitor p57(KIP2) is thought to be a potential tumor suppressor gene (TSG). The present study examines this possibility...
  18. Joaquin M, Watson R. The cell cycle-regulated B-Myb transcription factor overcomes cyclin-dependent kinase inhibitory activity of p57(KIP2) by interacting with its cyclin-binding domain. J Biol Chem. 2003;278:44255-64 pubmed
    ..No in vivo interaction was found with either p21(Waf1/Cip1) or p27(KIP1), however, binding to p57(KIP2) was readily detectable in both in vivo and in vitro assays...
  19. Lee M, Reynisdottir I, Massague J. Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev. 1995;9:639-49 pubmed
    ..We have isolated a new member of the p21CIP1/p27KIP1 CDI family and named it p57KIP2 to denote its apparent molecular mass and higher similarity to p27KIP1...
  20. Joseph B, Wallén Mackenzie A, Benoit G, Murata T, Joodmardi E, Okret S, et al. p57(Kip2) cooperates with Nurr1 in developing dopamine cells. Proc Natl Acad Sci U S A. 2003;100:15619-24 pubmed
    ..Here we show that p57Kip2 is expressed in postmitotic differentiating midbrain dopamine cells...
  21. Sun K, Wang W, Lei S, Wu C, Li G. [MicroRNA-221 promotes colon carcinoma cell proliferation in vitro by inhibiting CDKN1C/p57 expression]. Nan Fang Yi Ke Da Xue Xue Bao. 2011;31:1885-9 pubmed
    To investigate the regulatory effect of microRNA-221 (MIR221) on CDKN1C/p57 expression in colon carcinoma cells in vitro. Caco2 cells were treated with or without anti-p57-siRNA prior to the addition of pre-MIR221 or anti-MIR221...
  22. Fornari F, Gramantieri L, Ferracin M, Veronese A, Sabbioni S, Calin G, et al. MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma. Oncogene. 2008;27:5651-61 pubmed publisher
    ..Here, we proved that the cyclin-dependent kinase inhibitor (CDKI) CDKN1C/p57 is also a direct target of miR-221...
  23. Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, et al. Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation. Proc Natl Acad Sci U S A. 2003;100:10231-6 pubmed
    The abundance of the cyclin-dependent kinase (CDK) inhibitor p57Kip2, an important regulator of cell cycle progression, is thought to be controlled by the ubiquitin-proteasome pathway...
  24. Bozdogan O, Atasoy P, Batislam E, Basar M, Basar H. Significance of p57(Kip2) down-regulation in oncogenesis of bladder carcinoma: an immunohistochemical study. Tumori. 2008;94:556-62 pubmed
    ..The aim of this study was to establish the importance of p57(Kip2), a unique cyclin-dependent kinase inhibitor, in the oncogenesis of bladder carcinoma...
  25. Li J, Wu F, Usuki H, Kubo A, Masaki T, Fujita J, et al. Loss of p57KIP2 is associated with colorectal carcinogenesis. Int J Oncol. 2003;23:1537-43 pubmed
    The expression and significance of p57KIP2, an important inhibitor of the cell cycle, remain unclear during carcinogenesis and during late metastasis to lymph nodes of tumors...
  26. Tokino T, Urano T, Furuhata T, Matsushima M, Miyatsu T, Sasaki S, et al. Characterization of the human p57KIP2 gene: alternative splicing, insertion/deletion polymorphisms in VNTR sequences in the coding region, and mutational analysis. Hum Genet. 1996;97:625-31 pubmed
    We have isolated human cDNA and genomic clones of a gene termed p57KIP2, which is related to the p2I WAFI and p27 KIP1 genes that encode inducible inhibitors of cyclin-dependent kinase activity...
  27. Sengupta S, Nie J, Wagner R, Yang C, Stewart R, Thomson J. MicroRNA 92b controls the G1/S checkpoint gene p57 in human embryonic stem cells. Stem Cells. 2009;27:1524-8 pubmed publisher
    ..b>p57, a gene whose product inhibits G(1) to S-phase progression, is one of the predicted targets of miR-92b...
  28. Soejima H, Nakagawachi T, Zhao W, Higashimoto K, Urano T, Matsukura S, et al. Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer. Oncogene. 2004;23:4380-8 pubmed
  29. Arima T, Kamikihara T, Hayashida T, Kato K, Inoue T, Shirayoshi Y, et al. ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndrome. Nucleic Acids Res. 2005;33:2650-60 pubmed
    ..Mutations in ZAC and p57KIP2 have been implicated in transient neonatal diabetes mellitus (TNDB) and Beckwith-Wiedemann syndrome, respectively...
  30. Wang L, Ye X, Cai X, Su J, Ma R, Yin X, et al. Curcumin suppresses cell growth and invasion and induces apoptosis by down-regulation of Skp2 pathway in glioma cells. Oncotarget. 2015;6:18027-37 pubmed
    ..Mechanistically, we defined that curcumin markedly down-regulated Skp2 expression and subsequently up-regulated p57 expression...
  31. de Almeida Pereira L, Repossi M, Magalhães C, Azevedo R, Corrêa Velloso J, Ulrich H, et al. P2Y12 but not P2Y13 Purinergic Receptor Controls Postnatal Rat Retinogenesis In Vivo. Mol Neurobiol. 2018;: pubmed publisher
    ..are known to control retinal progenitor cell (RPC) proliferation by modulating expression of the p57KIP2, a cell cycle regulator...
  32. Giovannoni I, Boldrini R, Benedetti M, Inserra A, De Pasquale M, Francalanci P. Pediatric adrenocortical neoplasms: immunohistochemical expression of p57 identifies loss of heterozygosity and abnormal imprinting of the 11p15.5. Pediatr Res. 2017;81:468-472 pubmed publisher
    Diagnosis of adrenocortical neoplasms (ACN), in pediatric age, is based on Wieneke criteria. The p57, a cyclin-dependent kinase inhibitor, acts to negatively regulate cell proliferation and is frequently found dysregulated in cancer...
  33. Biaoxue R, Xiguang C, Hua L, Hui M, Shuanying Y, Wei Z, et al. Decreased expression of decorin and p57(KIP2) correlates with poor survival and lymphatic metastasis in lung cancer patients. Int J Biol Markers. 2011;26:9-21 pubmed
    Decorin, p57(KIP2), and TGF-beta 1 have been investigated as prognostic factors because they appear to be associated with tumorigenesis; however, the effect of decorin and p57(KIP2) in lung cancer remains poorly understood...
  34. Shen W, Xing F, Kong L, Chen S, Li H. Expression of imprinted genes related to Beckwith-Wiedemann syndrome in human oocytes and preimplantation embryos. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005;22:265-7 pubmed
    ..Using nested reverse transcription-PCR to analyze the expression of P57KIP2, LIT1, TSSC3 in human oocytes and preimplantation embryos...
  35. Duffy K, Grand K, Zelley K, Kalish J. Tumor Screening in Beckwith-Wiedemann Syndrome: Parental Perspectives. J Genet Couns. 2018;27:844-853 pubmed publisher
    Children with Beckwith-Wiedemann Syndrome (BWS) and Isolated Hemihypertrophy (IHH) are at an increased risk for developing tumors...
  36. Ozawa S, Wonodi C, Babalola O, Ismail T, Bridges J. Using best-worst scaling to rank factors affecting vaccination demand in northern Nigeria. Vaccine. 2017;35:6429-6437 pubmed publisher
    ..This study applies best-worst scaling (BWS) to rank various factors affecting parents' demand for routine childhood immunization...
  37. Chen K, Liu Y, Li C, Chang Y, Chang S. Prenatal diagnosis of paternal duplication of 11p15.5?14.3: Its implication of Beckwith-Wiedemann syndrome. Taiwan J Obstet Gynecol. 2016;55:877-880 pubmed publisher
    ..aberration with molecular cytogenetic approaches and explore its relationship with Beckwith-Wiedemann syndrome (BWS)...
  38. Kalish J, Boodhansingh K, Bhatti T, Ganguly A, Conlin L, Becker S, et al. Congenital hyperinsulinism in children with paternal 11p uniparental isodisomy and Beckwith-Wiedemann syndrome. J Med Genet. 2016;53:53-61 pubmed publisher
    ..Although HI has long been recognised to be common in children with Beckwith-Wiedemann syndrome (BWS), the underlying mechanism is not known...
  39. Duquesnes N, Callot C, Jeannot P, Daburon V, Nakayama K, Manenti S, et al. p57(Kip2) knock-in mouse reveals CDK-independent contribution in the development of Beckwith-Wiedemann syndrome. J Pathol. 2016;239:250-61 pubmed publisher
    CDKN1C encodes the cyclin-CDK inhibitor p57(Kip2) (p57), a negative regulator of the cell cycle and putative tumour suppressor...
  40. Henique C, Bollée G, Loyer X, Grahammer F, Dhaun N, Camus M, et al. Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis. Nat Commun. 2017;8:1829 pubmed publisher
    ..The CDK inhibitor p57Kip2 is a major target of miR-92a that constitutively safeguards podocyte cell cycle quiescence...
  41. Whitty J, Oliveira Gonçalves A. A Systematic Review Comparing the Acceptability, Validity and Concordance of Discrete Choice Experiments and Best-Worst Scaling for Eliciting Preferences in Healthcare. Patient. 2018;11:301-317 pubmed publisher
    ..to compare the acceptability, validity and concordance of discrete choice experiment (DCE) and best-worst scaling (BWS) stated preference approaches in health...
  42. Lueangsakulthai J, Phosri S, Theansungnoen T, Jangpromma N, Temsiripong T, McKendrick J, et al. Novel antioxidant and anti-inflammatory peptides from the Siamese crocodile (Crocodylus siamensis) hemoglobin hydrolysate. Biotechnol Appl Biochem. 2017;: pubmed publisher
    ..Peptide fraction P57 isolated from 6H-CHH was found to exhibit the highest nitric oxide radical inhibition activity (32.0%)...
  43. Roche Seruendo L, García Pinillos F, Auria Martin I, Bataller Cervero A, Latorre Román P, Soto Hermoso V. Effects of different percentages of body weight support on spatiotemporal step characteristics during running. J Sports Sci. 2017;:1-6 pubmed publisher
    This study aimed to determine the effect of different percentages of body weight support (BWS) on spatiotemporal step characteristics during running...
  44. Holm R, Førsund M, Nguyen M, Nesland J, Trope C. Expression of p15INK?b and p57KIP² and relationship with clinicopathological features and prognosis in patients with vulvar squamous cell carcinoma. PLoS ONE. 2013;8:e61273 pubmed publisher
    The cyclin-dependent kinase inhibitors p15(INK4b) and p57(KIP2) are important regulators of the cell cycle, and their abnormal expression has been detected in various tumors...
  45. Sun K, Zeng J, Wang W, Wu C, Lei S, Li G. [MicroRNA-221 controls CDKN1C/P57 expression in human colorectal carcinoma]. Zhonghua Wei Chang Wai Ke Za Zhi. 2011;14:279-83 pubmed
    To investigate the expression of microRNA-221 (miR-221) and CDKN1C/P57 in colorectal carcinoma (CRC) and adjacent non-cancerous tissues...
  46. Ungar W, Hadioonzadeh A, Najafzadeh M, Tsao N, Dell S, Lynd L. Parents and adolescents preferences for asthma control: a best-worst scaling choice experiment using an orthogonal main effects design. BMC Pulm Med. 2015;15:146 pubmed publisher
    ..of parents and adolescents with asthma with regard to asthma control parameters using best worst scaling (BWS)...
  47. Zariwala M, Liu J, Xiong Y. Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins. Oncogene. 1998;17:2787-98 pubmed
    ..These data suggest that the expression of these two G1 E-type cyclins may be similarly regulated by the pRb function, but distinctly by the p53 activity. ..
  48. Botnaru V, Rusu D, Munteanu O. Williams-Beuren syndrome--a rare cause of recurrent hemoptysis. Pneumologia. 2016;65:39-44 pubmed
    Williams-Beuren syndrome (WBS) is a rare genetic disease with a distinctive constellation of clinical findings...
  49. Mardaryev A, Liu B, Rapisarda V, Poterlowicz K, Malashchuk I, Rudolf J, et al. Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium. J Cell Biol. 2016;212:77-89 pubmed publisher
    ..with activation of numerous neuronal genes and genes encoding cyclin-dependent kinase inhibitors (p16/p19 and p57)...
  50. Xu J, Shin J, Park S, Kang S, Jeong S, Moon J, et al. Differences in the metabolic profiles and antioxidant activities of wild and cultivated black soybeans evaluated by correlation analysis. Food Res Int. 2017;100:166-174 pubmed publisher
    ..In this study, the non-targeted metabolic profiling of 26 soybean varieties, 15 wild black soybeans (WBS) and 11 cultivated black soybeans (CBS), using liquid chromatography-mass spectrometry (LC-MS) in combination with ..
  51. Ma Z, Gu S, Song M, Yan C, Hui B, Ji H, et al. Long non-coding RNA SNHG17 is an unfavourable prognostic factor and promotes cell proliferation by epigenetically silencing P57 in colorectal cancer. Mol Biosyst. 2017;13:2350-2361 pubmed publisher
    ..Mechanistic studies revealed the capability of lncRNA SNHG17 to epigenetically suppress P57 by binding to enhancer of zeste homolog 2 (a key component of polycomb repressive complex 2) in CRC cells, and ..
  52. Ferronato M, Alonso E, Salomón D, Fermento M, Gandini N, Quevedo M, et al. Antitumoral effects of the alkynylphosphonate analogue of calcitriol EM1 on glioblastoma multiforme cells. J Steroid Biochem Mol Biol. 2018;178:22-35 pubmed publisher
    ..showed that EM1 produces cell cycle arrest in the T98G cell line, which is accompanied by an increase in p21, p27, p57 protein levels and a decrease in cyclin D1, p-Akt-S473, p-ERK1/2 and c-Jun expression...
  53. Unek G, Ozmen A, Kipmen Korgun D, Korgun E. Immunolocalization of PCNA, Ki67, p27 and p57 in normal and dexamethasone-induced intrauterine growth restriction placental development in rat. Acta Histochem. 2012;114:31-40 pubmed publisher
    ..investigate the spatial and temporal immunolocalization of proliferating cell nuclear antigen (PCNA), Ki67, p27 and p57 in normal and IUGR placental development in pregnant Wistar rats...
  54. Suchi M, MacMullen C, Thornton P, Adzick N, Ganguly A, Ruchelli E, et al. Molecular and immunohistochemical analyses of the focal form of congenital hyperinsulinism. Mod Pathol. 2006;19:122-9 pubmed
    ..In addition, the hyperplastic endocrine cells show loss of maternal 11p15, where imprinted genes such as p57(kip2) reside...
  55. Ding L, Li R, Sun R, Zhou Y, Zhou Y, Han X, et al. S-phase kinase-associated protein 2 promotes cell growth and motility in osteosarcoma cells. Cell Cycle. 2017;16:1547-1555 pubmed publisher
    ..Mechanically, our Western blotting data suggested that Skp2 decreased the expression of E-cadherin, Foxo1, p21, and p57, but increased MMP-9 in OS cells...
  56. Singh V, Sribenja S, Wilson K, Attwood K, Hillman J, Pathak S, et al. Blocked transcription through KvDMR1 results in absence of methylation and gene silencing resembling Beckwith-Wiedemann syndrome. Development. 2017;144:1820-1830 pubmed publisher
    ..5. Disruption of imprinting leads to Beckwith-Wiedemann syndrome (BWS), an overgrowth and cancer predisposition condition...
  57. Romanelli V, Belinchon A, Campos Barros A, Heath K, Garcia Minaur S, Martinez Glez V, et al. CDKN1C mutations in HELLP/preeclamptic mothers of Beckwith-Wiedemann Syndrome (BWS) patients. Placenta. 2009;30:551-4 pubmed publisher
    ..To the best of our knowledge this is the first report of CDKN1C mutations in children born to women with preeclampsia/HELLP syndrome, thus suggesting the involvement of an imprinted gene in the pathophysiology of preeclampsia. ..
  58. Otieno S, Grace C, Kriwacki R. The role of the LH subdomain in the function of the Cip/Kip cyclin-dependent kinase regulators. Biophys J. 2011;100:2486-94 pubmed publisher
    The Cip/Kip protein family, which includes p27, p21, and p57, modulates the activity of cyclin-dependent kinases (Cdks)...
  59. Chen Z, Li D, Tong L, Stewart P, Chu C, Pflugfelder S. Targeted inhibition of p57 and p15 blocks transforming growth factor beta-inhibited proliferation of primary cultured human limbal epithelial cells. Mol Vis. 2006;12:983-94 pubmed
    To evaluate the role of cyclin-dependent kinase inhibitors p57 and p15 in transforming growth factor (TGF)-beta1 or TGF-beta2 inhibited proliferation of primary cultured human limbal epithelial cells using short interfering RNA (siRNA)...
  60. Giovanella L, Castellani M, Suriano S, Ruberto T, Ceriani L, Tagliabue L, et al. Multi-field-of-view SPECT is superior to whole-body scanning for assessing metastatic bone disease in patients with prostate cancer. Tumori. 2011;97:629-33 pubmed publisher
    The aim of this study was to compare the diagnostic performance of whole-body bone scintigraphy (WBS) and multi-field-of-view single photon emission tomography (multi-FOV SPECT) with 99mTc-oxidronate (99mTc-HDP) in patients with prostate ..
  61. Higashimoto K, Soejima H, Saito T, Okumura K, Mukai T. Imprinting disruption of the CDKN1C/KCNQ1OT1 domain: the molecular mechanisms causing Beckwith-Wiedemann syndrome and cancer. Cytogenet Genome Res. 2006;113:306-12 pubmed
    ..CDKN1C (alias p57KIP2), an imprinted gene with maternal expression, encoding a cyclin-dependent kinase inhibitor, is a critical gene ..
  62. Kavanagh E, Vlachos P, Emourgeon V, Rodhe J, Joseph B. p57(KIP2) control of actin cytoskeleton dynamics is responsible for its mitochondrial pro-apoptotic effect. Cell Death Dis. 2012;3:e311 pubmed publisher
    p57 (Kip2, cyclin-dependent kinase inhibitor 1C), often found downregulated in cancer, is reported to hold tumor suppressor properties...
  63. Gosselet F, Magnaldo T, Culerrier R, Sarasin A, Ehrhart J. BMP2 and BMP6 control p57(Kip2) expression and cell growth arrest/terminal differentiation in normal primary human epidermal keratinocytes. Cell Signal. 2007;19:731-9 pubmed
    ..we showed evidence that, of the three members of the Cip/Kip family of cyclin-dependent kinase inhibitors, only p57(Kip2) and p21(Cip1) have a BMP2/6-induced expression...
  64. Joaquin M, Gubern A, Gonzalez Nunez D, Josué Ruiz E, Ferreiro I, de Nadal E, et al. The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress. EMBO J. 2012;31:2952-64 pubmed publisher
    The p57(Kip2) cyclin-dependent kinase inhibitor (CDKi) has been implicated in embryogenesis, stem-cell senescence and pathologies, but little is known of its role in cell cycle control...
  65. Yokoo T, Toyoshima H, Miura M, Wang Y, Iida K, Suzuki H, et al. p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus. J Biol Chem. 2003;278:52919-23 pubmed
    b>p57Kip2 is the only cyclin-dependent kinase (Cdk) inhibitor shown to be essential for mouse embryogenesis. The fact suggests that p57 has a specific role that cannot be compensated by other Cdk inhibitors...
  66. Xu X, Wang W, Zhang L, Li Y, Tang M, Jiang N, et al. Clinical implications of p57 KIP2 expression in breast cancer. Asian Pac J Cancer Prev. 2012;13:5033-6 pubmed
    To study the relationship between expression of p57KIP2 and prognosis and other clinicopathological parameters in invasive breast cancers...
  67. Wang S, Yang Z, Li H. [Clinical and genetic characteristics of Williams-Beuren syndrome: 2 cases report]. Beijing Da Xue Xue Bao Yi Xue Ban. 2017;49:899-903 pubmed
    To explore the clinical and genetic characteristics of Williams-Beuren syndrome (WBS) and to raise awareness of the disease...
  68. Hamajima N, Johmura Y, Suzuki S, Nakanishi M, Saitoh S. Increased protein stability of CDKN1C causes a gain-of-function phenotype in patients with IMAGe syndrome. PLoS ONE. 2013;8:e75137 pubmed publisher
    ..These results thus suggested that the reduced-growth phenotype of IMAGe syndrome derives from CDKN1C gain-of-function due to IMAGe-associated mutations driving increased protein stability. ..
  69. Lelić M, Fatusic Z, Iljazovic E, Ramic S, Markovic S, Alicelebić S. Challenges in the Routine Praxis Diagnosis of Hydatidiform Mole: a Tertiary Health Center Experience. Med Arch. 2017;71:256-260 pubmed publisher
    ..Protein p57, encoded by CKDN1C gene, is paternally imprinted and maternally expressed gene and provides quick insight in ..
  70. Peng Y, Wu W, Chen L, Kuo K, Tsai C, Huang Y, et al. Upregulation of cyclin-dependent kinase inhibitors CDKN1B and CDKN1C in hepatocellular carcinoma-derived cells via goniothalamin-mediated protein stabilization and epigenetic modifications. Toxicol Rep. 2015;2:322-332 pubmed publisher
    ..insufficient cyclin-dependent kinase inhibitor 1B (CDKN1B, also known as p27Kip1) and CDKN1C (p57Kip2) proteins are characteristics of high-risk HCC...
  71. Neckel N. Novel spatiotemporal analysis of gait changes in body weight supported treadmill trained rats following cervical spinal cord injury. J Neuroeng Rehabil. 2017;14:96 pubmed publisher
    ..The performance of trained rats was recorded during training with BWS, as well as at the end of the training week without BWS...
  72. Reynaud E, Leibovitch M, Tintignac L, Pelpel K, Guillier M, Leibovitch S. Stabilization of MyoD by direct binding to p57(Kip2). J Biol Chem. 2000;275:18767-76 pubmed
    ..In the present study, we show that in presence of p57(Kip2), MyoD(Ala200), a MyoD mutant that cannot be phosphorylated by cyclin-Cdk complexes, displayed activity 2-5-fold ..
  73. He S, Limi S, McGreal R, Xie Q, Brennan L, Kantorow W, et al. Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation. Development. 2016;143:1937-47 pubmed publisher
    ..as a key regulator of lens vesicle polarity through spatial control of Prox1, Jag1, p27(Kip1) (Cdkn1b) and p57(Kip2) (Cdkn1c) gene expression. The abnormal Snf2h(-/-) fiber cells also retain their nuclei...