p53

Summary

Gene Symbol: p53
Description: tumor protein p53
Alias: BCC7, LFS1, P53, TRP53, antigen NY-CO-13, cellular tumor antigen p53, mutant tumor protein 53, p53 tumor suppressor, phosphoprotein p53, transformation-related protein 53, tumor protein 53
Species: human

Top Publications

  1. doi p53 polymorphisms: cancer implications
    Catherine Whibley
    Leeds Institute of Genetics, Health and Therapeutics, LIGHT Laboratories, University of Leeds, Leeds, LS2 9JT, UK
    Nat Rev Cancer 9:95-107. 2009
  2. doi Blinded by the Light: The Growing Complexity of p53
    Karen H Vousden
    The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Cell 137:413-31. 2009
  3. pmc Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
    Tsung Cheng Chang
    The McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell 26:745-52. 2007
  4. ncbi Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    M Serrano
    Cold Spring Harbor Laboratory, New York 11724, USA
    Cell 88:593-602. 1997
  5. ncbi p53 mutations in human cancers
    M Hollstein
    Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Science 253:49-53. 1991
  6. ncbi Modulation of microRNA processing by p53
    Hiroshi I Suzuki
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 460:529-33. 2009
  7. ncbi Transcriptional activation of miR-34a contributes to p53-mediated apoptosis
    Nina Raver-Shapira
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell 26:731-43. 2007
  8. ncbi p53-mediated activation of miRNA34 candidate tumor-suppressor genes
    Guido T Bommer
    Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109 2200, USA
    Curr Biol 17:1298-307. 2007
  9. ncbi p53 has a direct apoptogenic role at the mitochondria
    Motohiro Mihara
    Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA
    Mol Cell 11:577-90. 2003
  10. doi Mutant p53 drives invasion by promoting integrin recycling
    Patricia A J Muller
    The Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Cell 139:1327-41. 2009

Research Grants

  1. ALTERED PROTEOGLYCAN GENE EXPRESSION AND CANCER
    Renato V Iozzo; Fiscal Year: 2012
  2. ALTERED PROTEOGLYCAN GENE EXPRESSION AND CANCER
    Renato V Iozzo; Fiscal Year: 2013
  3. MECHANISMS OF P53 DEPENDENT APOPTOSIS
    H Ruley; Fiscal Year: 2000
  4. MECHANISMS OF P53 DEPENDENT APOPTOSIS
    H Ruley; Fiscal Year: 1999
  5. CHARACTERIZATION OF NEW HUMAN P53 DISSOCIATORS
    Rainer Brachmann; Fiscal Year: 2004
  6. CHARACTERIZATION OF NEW HUMAN P53 DISSOCIATORS
    Rainer Brachmann; Fiscal Year: 2002
  7. CHARACTERIZATION OF NEW HUMAN P53 DISSOCIATORS
    Rainer Brachmann; Fiscal Year: 2003
  8. CHARACTERIZATION OF NEW HUMAN P53 DISSOCIATORS
    Rainer Brachmann; Fiscal Year: 2000
  9. CHARACTERIZATION OF NEW HUMAN P53 DISSOCIATORS
    Rainer Brachmann; Fiscal Year: 2002
  10. CHARACTERIZATION OF NEW HUMAN P53 DISSOCIATORS
    Rainer Brachmann; Fiscal Year: 2001

Detail Information

Publications362 found, 100 shown here

  1. doi p53 polymorphisms: cancer implications
    Catherine Whibley
    Leeds Institute of Genetics, Health and Therapeutics, LIGHT Laboratories, University of Leeds, Leeds, LS2 9JT, UK
    Nat Rev Cancer 9:95-107. 2009
    The normal functioning of p53 is a potent barrier to cancer...
  2. doi Blinded by the Light: The Growing Complexity of p53
    Karen H Vousden
    The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Cell 137:413-31. 2009
    While the tumor suppressor functions of p53 have long been recognized, the contribution of p53 to numerous other aspects of disease and normal life is only now being appreciated...
  3. pmc Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
    Tsung Cheng Chang
    The McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell 26:745-52. 2007
    The p53 tumor suppressor protein is a critical regulator of the cellular response to cancer-initiating insults such as genotoxic stress...
  4. ncbi Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    M Serrano
    Cold Spring Harbor Laboratory, New York 11724, USA
    Cell 88:593-602. 1997
    ..of primary cells by ras requires either a cooperating oncogene or the inactivation of tumor suppressors such as p53 or p16...
  5. ncbi p53 mutations in human cancers
    M Hollstein
    Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Science 253:49-53. 1991
    Mutations in the evolutionarily conserved codons of the p53 tumor suppressor gene are common in diverse types of human cancer...
  6. ncbi Modulation of microRNA processing by p53
    Hiroshi I Suzuki
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 460:529-33. 2009
    ..Here we show that a central tumour suppressor, p53, enhances the post-transcriptional maturation of several miRNAs with growth-suppressive function, including miR-16-..
  7. ncbi Transcriptional activation of miR-34a contributes to p53-mediated apoptosis
    Nina Raver-Shapira
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell 26:731-43. 2007
    b>p53 is a potent tumor suppressor, whose biological effects are largely due to its function as a transcriptional regulator...
  8. ncbi p53-mediated activation of miRNA34 candidate tumor-suppressor genes
    Guido T Bommer
    Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109 2200, USA
    Curr Biol 17:1298-307. 2007
    In response to varied cell stress signals, the p53 tumor-suppressor protein activates a multitude of genes encoding proteins with functions in cell-cycle control, DNA repair, senescence, and apoptosis...
  9. ncbi p53 has a direct apoptogenic role at the mitochondria
    Motohiro Mihara
    Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA
    Mol Cell 11:577-90. 2003
    b>p53 induces apoptosis by target gene regulation and transcription-independent signaling. However, a mechanism for the latter was unknown...
  10. doi Mutant p53 drives invasion by promoting integrin recycling
    Patricia A J Muller
    The Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Cell 139:1327-41. 2009
    b>p53 is a tumor suppressor protein whose function is frequently lost in cancers through missense mutations within the Tp53 gene...
  11. ncbi Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest
    Valery Tarasov
    Molecular Oncology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Cell Cycle 6:1586-93. 2007
    In a genome-wide screen for microRNAs regulated by the transcription factor encoded by the p53 tumor suppressor gene we found that after p53-activation the abundance of thirty-four miRNAs was significantly increased, whereas sixteen ..
  12. ncbi Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
    W Gu
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
    Cell 90:595-606. 1997
    The tumor suppressor p53 exerts antiproliferation effects through its ability to function as a sequence-specific DNA-binding transcription factor. Here, we demonstrate that p53 can be modified by acetylation both in vivo and in vitro...
  13. doi A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis
    Maddalena Adorno
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padua School of Medicine, viale Colombo 3, 35100 Padua, Italy
    Cell 137:87-98. 2009
    ..Here, we show that TGFbeta-dependent cell migration, invasion and metastasis are empowered by mutant-p53 and opposed by p63...
  14. ncbi DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    S Y Shieh
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Cell 91:325-34. 1997
    DNA-damaging agents signal to p53 through as yet unidentified posttranscriptional mechanisms...
  15. ncbi Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
    Jerry E Chipuk
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Science 303:1010-4. 2004
    The tumor suppressor p53 exerts its anti-neoplastic activity primarily through the induction of apoptosis...
  16. pmc p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs
    Chun Ju Chang
    Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Nat Cell Biol 13:317-23. 2011
    ..Here, using genomic approaches, we show that tumour suppressor p53 has a role in regulating both EMT and EMT-associated stem cell properties through transcriptional activation of the ..
  17. pmc TP53 mutations in human cancers: origins, consequences, and clinical use
    Magali Olivier
    Group of Molecular Carcinogenesis, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Cold Spring Harb Perspect Biol 2:a001008. 2010
    ..All mutations found in human cancers are compiled in the IARC TP53 Database (http://www-p53.iarc.fr/)...
  18. pmc p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
    Taewan Kim
    Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, 2 Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, OH 43210, USA
    J Exp Med 208:875-83. 2011
    b>p53 suppresses tumor progression and metastasis. Epithelial-mesenchymal transition (EMT) is a key process in tumor progression and metastasis. The transcription factors ZEB1 and ZEB2 promote EMT...
  19. ncbi Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2
    Thomas G Hofmann
    Division of Immunochemistry G0200 German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nat Cell Biol 4:1-10. 2002
    Transcriptional activity of p53, a central regulatory switch in a network controlling cell proliferation and apoptosis, is modulated by protein stability and post-translational modifications including phosphorylation and acetylation...
  20. pmc Regulation of autophagy by cytoplasmic p53
    Ezgi Tasdemir
    INSERM, U848, France
    Nat Cell Biol 10:676-87. 2008
    Multiple cellular stressors, including activation of the tumour suppressor p53, can stimulate autophagy...
  21. ncbi Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis
    Gabriella D'Orazi
    Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Via delle Messi d Oro 156, 00158 Rome, Italy
    Nat Cell Biol 4:11-9. 2002
    Phosphorylation of p53 at Ser 46 was shown to regulate p53 apoptotic activity...
  22. ncbi Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis
    Yi Tang
    Institute for Cancer Genetics, Surgeons, Columbia University, 1150 St Nicholas Ave, New York, New York 10032, USA
    Mol Cell 24:827-39. 2006
    Upon DNA damage and other types of stress, p53 induces either cell-cycle arrest or apoptosis depending on the cellular context...
  23. ncbi Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
    D Malkin
    Division of Molecular Genetics, Massachusetts General Hospital Cancer Center, Charlestown 02129
    Science 250:1233-8. 1990
    ..The alternative approach was to select the most plausible candidate gene. The tumor suppressor gene, p53, was studied because of previous indications that this gene is inactivated in the sporadic (nonfamilial) forms of ..
  24. pmc Mutant p53 gain-of-function in cancer
    Moshe Oren
    Department of Molecular Cell Biology, The Weizmann Institute, Rehovot 76100, Israel
    Cold Spring Harb Perspect Biol 2:a001107. 2010
    In its wild-type form, p53 is a major tumor suppressor whose function is critical for protection against cancer. Many human tumors carry missense mutations in the TP53 gene, encoding p53...
  25. pmc p53 post-translational modification: deregulated in tumorigenesis
    Chao Dai
    Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, 1130 St Nicholas Avenue, New York, NY 10032, USA
    Trends Mol Med 16:528-36. 2010
    The p53 tumor suppressor protein has well-established roles in monitoring various types of stress signals by activating specific transcriptional targets that control cell cycle arrest and apoptosis, although some activities are also ..
  26. pmc Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
    Wenwei Hu
    Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA
    Proc Natl Acad Sci U S A 107:7455-60. 2010
    ..cycle arrest, apoptosis, and senescence are traditionally thought of as the major functions of the tumor suppressor p53, recent studies revealed two unique functions for this protein: p53 regulates cellular energy metabolism and ..
  27. pmc Acetylation is indispensable for p53 activation
    Yi Tang
    Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell 133:612-26. 2008
    The activation of the tumor suppressor p53 facilitates the cellular response to genotoxic stress; however, the p53 response can only be executed if its interaction with its inhibitor Mdm2 is abolished...
  28. doi Gain of function of mutant p53 by coaggregation with multiple tumor suppressors
    Jie Xu
    Switch Laboratory, Flanders Institute for Biotechnology, Vrije Universiteit Brussel, Brussels, Belgium
    Nat Chem Biol 7:285-95. 2011
    Many p53 missense mutations possess dominant-negative activity and oncogenic gain of function...
  29. pmc Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage
    Eric Batchelor
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 30:277-89. 2008
    DNA damage initiates a series of p53 pulses. Although much is known about the interactions surrounding p53, little is known about which interactions contribute to p53's dynamical behavior...
  30. pmc Acetylation of the p53 DNA-binding domain regulates apoptosis induction
    Stephen M Sykes
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Mol Cell 24:841-51. 2006
    The ability of p53 to induce apoptosis plays an important role in tumor suppression. Here, we describe a previously unknown posttranslational modification of the DNA-binding domain of p53...
  31. pmc P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis
    Munekazu Yamakuchi
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 107:6334-9. 2010
    ..Here we show that p53 regulates hypoxic signaling through the transcriptional regulation of microRNA-107 (miR-107)...
  32. ncbi ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    Y Zhang
    Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, 27599 3280, USA
    Cell 92:725-34. 1998
    ..p16INK4 binds to and inhibits the activity of CDK4 and CDK6, and ARF arrests the cell cycle in a p53-dependent manner. We show here that ARF binds to MDM2 and promotes the rapid degradation of MDM2...
  33. pmc A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53
    Surojit Sur
    The Howard Hughes Medical Institute and The Ludwig Center for Cancer Genetics and Therapeutics, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 106:3964-9. 2009
    ..This hypothesis was validated by demonstrating that stressed cancer cells without WT TP53 alleles were highly sensitive to PLK1 inhibitors, both in vivo and in vitro...
  34. pmc Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis
    Shunsuke Kato
    Department of Clinical Oncology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai 980 8575, Japan
    Proc Natl Acad Sci U S A 100:8424-9. 2003
    Inactivation of the tumor suppressor p53 by missense mutations is the most frequent genetic alteration in human cancers...
  35. ncbi Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
    Natalia Issaeva
    Microbiology and Tumor Biology Center, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Nat Med 10:1321-8. 2004
    In tumors that retain wild-type p53, its tumor-suppressor function is often impaired as a result of the deregulation of HDM-2, which binds to p53 and targets it for proteasomal degradation...
  36. pmc Wild-type p53 controls cell motility and invasion by dual regulation of MET expression
    Chang Il Hwang
    Department of Biomedical Sciences, Microarray Core Facility, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 108:14240-5. 2011
    Recent observations suggest that p53 mutations are responsible not only for growth of primary tumors but also for their dissemination...
  37. doi Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity
    Saifeng Wang
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences CAS, Beijing, PR China
    Hepatology 55:730-41. 2012
    ..and electrophoretic mobility shift assay, we further demonstrated that cyclin G(1) specifically interacted with p53, and this interaction blocked the specific binding of p53 to HBV enhancer elements and simultaneously abrogated p53-..
  38. ncbi p53 is regulated by the lysine demethylase LSD1
    Jing Huang
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nature 449:105-8. 2007
    b>p53, the tumour suppressor and transcriptional activator, is regulated by numerous post-translational modifications, including lysine methylation...
  39. ncbi Acetylation of p53 inhibits its ubiquitination by Mdm2
    Muyang Li
    Institute for Cancer Genetics, and Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 277:50607-11. 2002
    In response to DNA damage, the activity of the p53 tumor suppressor is modulated by protein stabilization and post-translational modifications including acetylation...
  40. ncbi Regulation of HDM2 activity by the ribosomal protein L11
    Marion A E Lohrum
    Regulation of Cell Growth Laboratory, NCI FRCDC, Frederick, MD 21702, USA
    Cancer Cell 3:577-87. 2003
    The HDM2 protein plays an important role in regulating the stability and function of the p53 tumor suppressor protein...
  41. ncbi Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5
    Mu Shui Dai
    Department of Biochemistry and Molecular Biology, School of Medicine, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Biol Chem 279:44475-82. 2004
    ..Both L11 and L23 have been shown to activate p53 by inhibiting MDM2-mediated p53 suppression. Here we have shown that L5 also activates p53...
  42. pmc Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53
    Ting Wang
    Center for Biomolecular Science and Engineering, and Howard Hughes Medical Institute, University of California, Santa Cruz, CA 95064, USA
    Proc Natl Acad Sci U S A 104:18613-8. 2007
    ..retrovirus (ERV) retroelements impact considerably the transcriptional network of human tumor suppressor protein p53. A total of 1,509 of approximately 319,000 human ERV LTR regions have a near-perfect p53 DNA binding site...
  43. ncbi Mono- versus polyubiquitination: differential control of p53 fate by Mdm2
    Muyang Li
    Institute for Cancer Genetics and Department of Pathology, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Science 302:1972-5. 2003
    Although Mdm2-mediated ubiquitination is essential for both degradation and nuclear export of p53, the molecular basis for the differential effects of Mdm2 remains unknown...
  44. ncbi TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes
    A Petitjean
    International Agency for Research on Cancer, Lyon, France
    Oncogene 26:2157-65. 2007
    ..New data on mutant p53 protein function, cancer phenotype and prognosis have recently been integrated in the International Agency for ..
  45. pmc Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
    Sawako Suzuki
    Department of Clinical Cell Biology and Division of Endocrinology and Metabolism, Chiba University Graduate School of Medicine, Chiba shi, Chiba 260 8670, Japan
    Proc Natl Acad Sci U S A 107:7461-6. 2010
    ..Thus, our results provide evidence for a unique metabolic role for p53, linking glutamine metabolism, energy, and ROS homeostasis, which may contribute to p53 tumor suppressor function.
  46. pmc Paradoxical suppression of cellular senescence by p53
    Zoya N Demidenko
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Proc Natl Acad Sci U S A 107:9660-4. 2010
    The tumor suppressor p53 is a canonical inducer of cellular senescence (irreversible loss of proliferative potential and senescent morphology)...
  47. pmc p53 mutant breast cancer patients expressing p53γ have as good a prognosis as wild-type p53 breast cancer patients
    Jean Christophe Bourdon
    Centre for Oncology and Molecular Medicine, Inserm European Associated Laboratory, University of Dundee, Dundee, DD1 9SY, UK
    Breast Cancer Res 13:R7. 2011
    Normal function of the p53 network is lost in most cancers, often through p53 mutation. The clinical impact of p53 mutations in breast cancer remains uncertain, especially where p53 isoforms may modify the effects of these p53 mutations.
  48. doi Beyond Li Fraumeni Syndrome: clinical characteristics of families with p53 germline mutations
    Kelly D Gonzalez
    Departments of Molecular Diagnosis, Molecular Genetics, Clinical Cancer Genetics, and Information Sciences, and the Bioinformatics Group, City of Hope, Duarte, CA 91010 0269, USA
    J Clin Oncol 27:1250-6. 2009
    A clinical testing cohort was used to gain a broader understanding of the spectrum of tumors associated with germline p53 mutations to aid clinicians in identifying high-risk families.
  49. pmc MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation
    Wei Fu
    Department of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    J Biol Chem 284:13987-4000. 2009
    ..In cells stably expressing a temperature-sensitive p53 mutant, activation of p53 by shifting to permissive temperatures leads to MDM2 induction and degradation of ..
  50. pmc Expression signatures of TP53 mutations in serous ovarian cancers
    Marcus Q Bernardini
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Toronto, 600 University Avenue, Toronto, Ontario M5G2M9, Canada
    BMC Cancer 10:237. 2010
    ..Mutations in the TP53 gene are extremely common and occur very early in the progression of serous ovarian cancers. Gene expression patterns that relate to mutational status may provide insight into the etiology and biology of the disease...
  51. ncbi p53 and breast cancer, an update
    Marc Lacroix
    Laboratoire Jean Claude Heuson de Cancérologie Mammaire, Institut Jules Bordet Université Libre de Bruxelles, 127 boulevard de Waterloo, B 1000 Bruxelles, Belgium
    Endocr Relat Cancer 13:293-325. 2006
    b>p53 plays a key role in mediating cell response to various stresses, mainly by inducing or repressing a number of genes involved in cell cycle arrest, senescence, apoptosis, DNA repair, and angiogenesis...
  52. pmc Regulation of p53 target gene expression by peptidylarginine deiminase 4
    Pingxin Li
    Center for Gene Regulation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    Mol Cell Biol 28:4745-58. 2008
    Histone Arg methylation has been correlated with transcriptional activation of p53 target genes. However, whether this modification is reversed to repress the expression of p53 target genes is unclear...
  53. ncbi The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer
    Magali Olivier
    IARC, Lyon, France
    Clin Cancer Res 12:1157-67. 2006
    ..These results, obtained on the largest series analyzed thus far, show that TP53 mutations identified by gene sequencing have an independent prognostic value in breast cancer and could have potential uses in clinical practice...
  54. pmc The p53 orchestra: Mdm2 and Mdmx set the tone
    Mark Wade
    Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Trends Cell Biol 20:299-309. 2010
    The activities of p53 cover diverse aspects of cell biology, including cell cycle control, apoptosis, metabolism, fertility, differentiation and cellular reprogramming...
  55. pmc The combined status of ATM and p53 link tumor development with therapeutic response
    Hai Jiang
    The Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 23:1895-909. 2009
    ..Specifically, evaluation of the combined status of ATM and p53, two commonly mutated tumor suppressor genes, can help to predict the clinical response to genotoxic chemotherapies...
  56. pmc A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition
    Nam Hee Kim
    Department of Oral Pathology, Oral Cancer Research Institute, College of Dentistry, Yonsei University, Seoul 120 752, South Korea
    J Cell Biol 195:417-33. 2011
    ..Herein, we demonstrate that p53 loss-of-function or mutation promotes cancer cell EMT by de-repressing Snail1 protein expression and activity...
  57. ncbi Cross talk between stimulated NF-kappaB and the tumor suppressor p53
    G Schneider
    Klinikum rechts der Isar, II, Medizinische Klinik, Technische Universitat Munchen, Munchen, Germany
    Oncogene 29:2795-806. 2010
    Nuclear factor-kappaB (NF-kappaB) and p53 critically determine cancer development and progression. Defining the cross talk between these transcription factors can expand our knowledge on molecular mechanisms of tumorigenesis...
  58. ncbi Deacetylation of p53 modulates its effect on cell growth and apoptosis
    J Luo
    Institute of Cancer Genetics, and Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Nature 408:377-81. 2000
    The p53 tumour suppressor is a transcriptional factor whose activity is modulated by protein stability and post-translational modifications including acetylation...
  59. ncbi The ubiquitin ligase COP1 is a critical negative regulator of p53
    David Dornan
    Department of Molecular Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 429:86-92. 2004
    ..2). The role of COP1 in mammalian cells is less well characterized. Here we identify the tumour-suppressor protein p53 as a COP1-interacting protein...
  60. ncbi Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
    J I Ju Leu
    Department of Genetics, University of Pennsylvania School of Medicine, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Nat Cell Biol 6:443-50. 2004
    The tumour suppressor activity of the p53 protein has been explained by its ability to induce apoptosis in response to a variety of cellular stresses...
  61. ncbi Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
    Vladimir J N Bykov
    Karolinska Institutet, Department of Oncology Pathology, Cancer Center Karolinska, Karolinska Hospital, Stockholm, Sweden
    Nat Med 8:282-8. 2002
    The tumor suppressor p53 inhibits tumor growth primarily through its ability to induce apoptosis. Mutations in p53 occur in at least 50% of human tumors...
  62. pmc Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells
    Alexander Loewer
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 142:89-100. 2010
    The tumor suppressor p53 is activated by stress and leads to cellular outcomes such as apoptosis and cell-cycle arrest. Its activation must be highly sensitive to ensure that cells react appropriately to damage...
  63. ncbi Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function
    D Chen
    Department of Pharmacology and Toxicology, Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Oncogene 26:5029-37. 2007
    As a major negative regulator of p53, the MDM2 oncogene plays an important role in carcinogenesis and tumor progression. MDM2 promotes p53 proteasomal degradation and negatively regulates p53 function...
  64. ncbi p21/CDKN1A mediates negative regulation of transcription by p53
    Kristina Löhr
    Institut fur Virologie, Philipps Universitat Marburg, Robert Koch str 17, 35037 Marburg, Germany
    J Biol Chem 278:32507-16. 2003
    The tumor suppressor p53 regulates transcription positively and negatively, depending on the target gene...
  65. ncbi MDM2--master regulator of the p53 tumor suppressor protein
    J Momand
    California State University at Los Angeles, Department of Chemistry and Biochemistry, 90032, USA
    Gene 242:15-29. 2000
    MDM2 is an oncogene that mainly functions to modulate p53 tumor suppressor activity...
  66. ncbi Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases
    N A Barlev
    Molecular Genetics Program, The Wistar Institute, Philadelphia, PA 19104, USA
    Mol Cell 8:1243-54. 2001
    Cellular DNA damage causes stabilization and activation of the tumor suppressor and transcription factor p53, in part by promoting multiple covalent modifications of the p53 protein, including acetylation...
  67. pmc TP53 mutations and survival in squamous-cell carcinoma of the head and neck
    M Luana Poeta
    Johns Hopkins University, Baltimore, MD 21287, USA
    N Engl J Med 357:2552-61. 2007
    The abrogation of function of the tumor-suppressor protein p53 as a result of mutation of its gene, TP53, is one of the most common genetic alterations in cancer cells...
  68. pmc Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a
    M Murphy
    Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Genes Dev 13:2490-501. 1999
    There is growing evidence that the p53 tumor suppressor protein not only can function to activate gene transcription but also to repress the expression of specific genes...
  69. doi EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset
    Kentaro Inamura
    Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, Koto ku, Tokyo, Japan
    Mod Pathol 22:508-15. 2009
    ....
  70. pmc Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition
    Mu Shui Dai
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97201, USA
    Mol Cell Biol 24:7654-68. 2004
    The p53-MDM2 feedback loop is vital for cell growth control and is subjected to multiple regulations in response to various stress signals. Here we report another regulator of this loop...
  71. pmc Interaction of the p53 DNA-binding domain with its n-terminal extension modulates the stability of the p53 tetramer
    Eviatar Natan
    MRC Laboratory of Molecular Biology, Cambridge, UK
    J Mol Biol 409:358-68. 2011
    The tetrameric tumor suppressor p53 plays a pivotal role in the control of the cell cycle and provides a paradigm for an emerging class of oligomeric, multidomain proteins with structured and intrinsically disordered regions...
  72. ncbi Regulation of p53 activity through lysine methylation
    Sergei Chuikov
    Howard Hughes Medical Institute, Division of Nucleic Acids Enzymology, Department of Biochemistry, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Nature 432:353-60. 2004
    b>p53 is a tumour suppressor that regulates the cellular response to genotoxic stresses. p53 is a short-lived protein and its activity is regulated mostly by stabilization via different post-translational modifications...
  73. pmc HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase
    Ataman Sendoel
    Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Nature 465:577-83. 2010
    ..germ cell apoptosis by antagonizing the function of CEP-1, the homologue of the tumour suppressor p53. The antiapoptotic property of HIF-1 is mediated by means of transcriptional upregulation of the tyrosinase family ..
  74. pmc Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway
    Yanping Zhang
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 23:8902-12. 2003
    The gene encoding p53 mediates a major tumor suppression pathway that is frequently altered in human cancers. p53 function is kept at a low level during normal cell growth and is activated in response to various cellular stresses...
  75. ncbi Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cells
    Soo Jin Jeong
    Virus Tumor Biology Section, Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 5055, USA
    Oncogene 24:6719-28. 2005
    ..that AKT is activated in HTLV-1-transformed cells and that Tax activation of AKT is linked to NF-kappaB activation, p53 inhibition and cell survival...
  76. ncbi Shaping genetic alterations in human cancer: the p53 mutation paradigm
    Thierry Soussi
    Université P M Curie, 4 place Jussieu, 75005 Paris, France
    Cancer Cell 12:303-12. 2007
    b>p53 mutations are found in 50% of human cancers. Molecular epidemiology has shown strong correlations between the spectrum of p53 mutations and exposure to exogenous carcinogens...
  77. pmc PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney St, Room JF 215C, Boston, MA 02115 USA
    J Clin Oncol 27:1477-84. 2009
    ..PIK3CA mutation and subsequent activation of the AKT pathway play an important role in colorectal carcinogenesis. However, little is known about the prognostic role of PIK3CA mutation in colon cancer...
  78. pmc Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain
    Mark Wells
    MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 0QH, United Kingdom
    Proc Natl Acad Sci U S A 105:5762-7. 2008
    ..Having solved the quaternary structure of the folded domains in the tumor suppressor p53 by a multidisciplinary approach, we have now determined the average ensemble structure of the intrinsically ..
  79. ncbi Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
    W G An
    Department of Cell and Cancer Biology, Medicine Branch, NCI, NIH, Bethesda, Maryland 20892, USA
    Nature 392:405-8. 1998
    Although hypoxia (lack of oxygen in body tissues) is perhaps the most physiological inducer of the wild-type p53 gene, the mechanism of this induction is unknown...
  80. ncbi Synergistic activation of transcription by CBP and p53
    W Gu
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York 10021, USA
    Nature 387:819-23. 1997
    The tumour suppressor p53 is a transcriptional regulator whose ability to inhibit cell growth is dependent upon its transactivation function...
  81. ncbi Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53
    Hiroshi Katayama
    Department of Molecular Pathology, Division of Pathology and Laboratory Medicine, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Genet 36:55-62. 2004
    ..chromosome instability and oncogenic transformation, a phenotype characteristic of loss-of-function mutations of p53. Here we show that aurora kinase A phosphorylates p53 at Ser315, leading to its ubiquitination by Mdm2 and ..
  82. pmc p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation
    Tamara Terzian
    Department of Dermatology and Charles C Gates Center for Regenerative Medicine and Stem Cell Biology, UC Denver, Aurora, CO 80045, USA
    Pigment Cell Melanoma Res 23:781-94. 2010
    b>p53 is the central member of a critical tumor suppressor pathway in virtually all tumor types, where it is silenced mainly by missense mutations. In melanoma, p53 predominantly remains wild type, thus its role has been neglected...
  83. ncbi Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms
    P D Jeffrey
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Science 267:1498-502. 1995
    The p53 protein is a tetrameric transcription factor that plays a central role in the prevention of neoplastic transformation...
  84. pmc Regulation of nucleolar signalling to p53 through NEDDylation of L11
    Anders Sundqvist
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, Scotland, UK
    EMBO Rep 10:1132-9. 2009
    Several studies have shown that ribosomal proteins (RPs) are important mediators of p53 activation in response to nucleolar disruption; however, the pathways that control this signalling function of RPs are currently unknown...
  85. ncbi p53 proteasomal degradation: poly-ubiquitination is not the whole story
    Gad Asher
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Cell Cycle 4:1015-8. 2005
    ..Studies on the tumor suppressor p53 have indeed demonstrated that poly-ubiquitination of p53 by different E3 ubiquin ligases targets p53 for ..
  86. ncbi p53 regulates mitochondrial respiration
    Satoaki Matoba
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Science 312:1650-3. 2006
    ..Here, we show that p53, one of the most frequently mutated genes in cancers, modulates the balance between the utilization of respiratory ..
  87. ncbi Yin Yang 1 is a negative regulator of p53
    Guangchao Sui
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Cell 117:859-72. 2004
    ..We find that YY1 ablation results in p53 accumulation due to a reduction of p53 ubiquitination in vivo...
  88. pmc p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation
    Ran Brosh
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Mol Syst Biol 4:229. 2008
    ..we investigated the mammalian cell proliferation control network consisting of transcriptional regulators, E2F and p53, their targets and a family of 15 miRNAs...
  89. pmc Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence
    Kensuke Kumamoto
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4258, USA
    Cancer Res 68:3193-203. 2008
    Nutlin-3, an MDM2 inhibitor, activates p53, resulting in several types of cancer cells undergoing apoptosis. Although p53 is mutated or deleted in approximately 50% of all cancers, p53 is still functionally active in the other 50%...
  90. ncbi Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity
    Dimitris P Xirodimas
    University of Dundee, Ninewells Hospital and Medical School, Department of Surgery and Molecular Oncology, Dundee DD1 9SY, UK
    Cell 118:83-97. 2004
    ..Here, we show that the Mdm2 RING finger E3 ubiquitin ligase can also promote NEDD8 modification of the p53 tumor suppressor protein...
  91. pmc Origin licensing and p53 status regulate Cdk2 activity during G(1)
    Kathleen R Nevis
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Cell Cycle 8:1952-63. 2009
    ..Co-depletion of Cdc6 and p53 in normal cells restored Cdk2 activation and Rb phosphorylation, permitting them to enter S phase with a reduced ..
  92. doi PRIMA-1 reactivates mutant p53 by covalent binding to the core domain
    Jeremy M R Lambert
    Department of Oncology Pathology, Cancer Center Karolinska, Karolinska Institutet, SE 171 76 Stockholm, Sweden International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Cancer Cell 15:376-88. 2009
    Restoration of wild-type p53 expression triggers cell death and eliminates tumors in vivo...
  93. pmc Ribosomal protein S7 is both a regulator and a substrate of MDM2
    Yan Zhu
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Mol Cell 35:316-26. 2009
    ..S7, and this interaction is required to inhibit MDM2's E3 ligase activity, leading to stabilization of MDM2 and p53. Notably, the MDM2 homolog MDMX facilitates the inhibition of MDM2 E3 ligase activity by S7...
  94. ncbi C-terminal modifications regulate MDM2 dissociation and nuclear export of p53
    Stephanie Carter
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
    Nat Cell Biol 9:428-35. 2007
    b>p53 functions to prevent malignant progression, in part by inhibiting proliferation or inducing the death of potential tumour cells...
  95. pmc Monoubiquitylation promotes mitochondrial p53 translocation
    Natasha D Marchenko
    Department of Pathology, Stony Brook University, Stony Brook, New York, NY 11794 869, USA
    EMBO J 26:923-34. 2007
    A major function of the p53 tumor suppressor is the induction of a pleiotropic apoptotic program in response to stress through transcription-dependent and -independent mechanisms...
  96. ncbi hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
    H Vaziri
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 107:149-59. 2001
    DNA damage-induced acetylation of p53 protein leads to its activation and either growth arrest or apoptosis. We show here that the protein product of the gene hSIR2(SIRT1), the human homolog of the S...
  97. doi Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation
    Carolyn Ying Zhao
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Cancer Res 70:3372-81. 2010
    Proteasomal degradation of p53 by human papilloma virus (HPV) E6 oncoprotein plays a pivotal role in the survival of cervical carcinoma cells...
  98. doi Inhibition of β-TrcP-dependent ubiquitination of p53 by HIV-1 Vpu promotes p53-mediated apoptosis in human T cells
    Sachin Verma
    Laboratory of Virology, National Institute of Immunology, New Delhi, India
    Blood 117:6600-7. 2011
    ..of wild-type Vpu protein with SCF complex leads to inhibition of ubiquitination and proteasomal degradation of p53 protein in a β-TrcP-dependent manner...
  99. ncbi Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2
    Erik Meulmeester
    Department of Molecular and Cell Biology, Leiden University Medical Center, P O Box 9503, 2300 RA Leiden, The Netherlands
    Mol Cell 18:565-76. 2005
    The p53 tumor suppressor protein has a major role in protecting the integrity of the genome. In unstressed cells, p53 is maintained at low levels by the ubiquitin-proteasome pathway...
  100. ncbi The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo
    Harumi Shimizu
    Department of Molecular and Cellular Pathology, The Cancer Research UK Laboratories, The University of Dundee, Dundee DD1 9SY, Scotland
    J Biol Chem 277:28446-58. 2002
    Although the N-terminal BOX-I domain of the tumor suppressor protein p53 contains the primary docking site for MDM2, previous studies demonstrated that RNA stabilizes the MDM2.p53 complex using a p53 mutant lacking the BOX-I motif...
  101. ncbi Estrogen receptor alpha inhibits p53-mediated transcriptional repression: implications for the regulation of apoptosis
    Aejaz Sayeed
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 67:7746-55. 2007
    Estrogen receptor alpha (ERalpha) and tumor suppressor protein p53 exert opposing effects on cellular proliferation. As a transcriptional regulator, p53 is capable of activating or repressing various target genes...

Research Grants122 found, 100 shown here

  1. ALTERED PROTEOGLYCAN GENE EXPRESSION AND CANCER
    Renato V Iozzo; Fiscal Year: 2012
    ..a targeted disruption of decorin develop spontaneous colon tumors and mice with a double knock out of decorin and p53 genes die rapidly of thymic lymphomas, indicating that lack of decorin is permissive for tumorigenesis...
  2. ALTERED PROTEOGLYCAN GENE EXPRESSION AND CANCER
    Renato V Iozzo; Fiscal Year: 2013
    ..a targeted disruption of decorin develop spontaneous colon tumors and mice with a double knock out of decorin and p53 genes die rapidly of thymic lymphomas, indicating that lack of decorin is permissive for tumorigenesis...
  3. MECHANISMS OF P53 DEPENDENT APOPTOSIS
    H Ruley; Fiscal Year: 2000
    Experiments are described to understand mechanisms of tumor suppression by p53 and to characterize biochemical regulation of p53 and the cellular responses to p53 action...
  4. MECHANISMS OF P53 DEPENDENT APOPTOSIS
    H Ruley; Fiscal Year: 1999
    Experiments are described to understand mechanisms of tumor suppression by p53 and to characterize biochemical regulation of p53 and the cellular responses to p53 action...
  5. CHARACTERIZATION OF NEW HUMAN P53 DISSOCIATORS
    Rainer Brachmann; Fiscal Year: 2004
    The human tumor suppressor protein and transcription factor p53 integrates stress signals, such as DNA damage, hypoxia and ribonucleotide depletion, and induces either cell cycle arrest or apoptosis...
  6. CHARACTERIZATION OF NEW HUMAN P53 DISSOCIATORS
    Rainer Brachmann; Fiscal Year: 2002
    The human tumor suppressor protein and transcription factor p53 integrates stress signals, such as DNA damage, hypoxia and ribonucleotide depletion, and induces either cell cycle arrest or apoptosis...
  7. CHARACTERIZATION OF NEW HUMAN P53 DISSOCIATORS
    Rainer Brachmann; Fiscal Year: 2003
    The human tumor suppressor protein and transcription factor p53 integrates stress signals, such as DNA damage, hypoxia and ribonucleotide depletion, and induces either cell cycle arrest or apoptosis...
  8. CHARACTERIZATION OF NEW HUMAN P53 DISSOCIATORS
    Rainer Brachmann; Fiscal Year: 2000
    The human tumor suppressor protein and transcription factor p53 integrates stress signals, such as DNA damage, hypoxia and ribonucleotide depletion, and induces either cell cycle arrest or apoptosis...
  9. CHARACTERIZATION OF NEW HUMAN P53 DISSOCIATORS
    Rainer Brachmann; Fiscal Year: 2002
    The human tumor suppressor protein and transcription factor p53 integrates stress signals, such as DNA damage, hypoxia and ribonucleotide depletion, and induces either cell cycle arrest or apoptosis...
  10. CHARACTERIZATION OF NEW HUMAN P53 DISSOCIATORS
    Rainer Brachmann; Fiscal Year: 2001
    The human tumor suppressor protein and transcription factor p53 integrates stress signals, such as DNA damage, hypoxia and ribonucleotide depletion, and induces either cell cycle arrest or apoptosis...
  11. Synthetic Lethal Targeting of p53 in Myelodysplasia
    A Thomas Look; Fiscal Year: 2010
    ..targeted therapy for a subset of MDS patients defined by a high frequency of complex aberrant karyotypes and p53 mutations (MDS-CAK, ~20% of all MDS cases)...
  12. Synthetic Lethal Targeting of p53 in Myelodysplasia
    A Look; Fiscal Year: 2009
    ..targeted therapy for a subset of MDS patients defined by a high frequency of complex aberrant karyotypes and p53 mutations (MDS-CAK, ~20% of all MDS cases)...
  13. Synthetic Lethal Targeting of p53 in Myelodysplasia
    A Look; Fiscal Year: 2007
    ..targeted therapy for a subset of MDS patients defined by a high frequency of complex aberrant karyotypes and p53 mutations (MDS-CAK, ~20% of all MDS cases)...
  14. The role of DNA polymerase eta in DNA damage response and p53 activation
    Xinbin Chen; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: It is well-known that loss of p53 tumor suppressor leads to genome instability and Xeroderma Pigmentosum (XP) patients often exhibit a high frequency of ..
  15. MDMX REGULATION OF THE P53 TUMOR SUPPRESSOR PROTEIN
    STEVEN BERBERICH; Fiscal Year: 2004
    ..Inactivation of the p53 tumor suppressor gene represents the most common genetic abnormality found in human cancer [1]...
  16. MDMX REGULATION OF THE P53 TUMOR SUPPRESSOR PROTEIN
    STEVEN BERBERICH; Fiscal Year: 2002
    ..Inactivation of the p53 tumor suppressor gene represents the most common genetic abnormality found in human cancer [1]...
  17. MDMX REGULATION OF THE P53 TUMOR SUPPRESSOR PROTEIN
    STEVEN BERBERICH; Fiscal Year: 2001
    ..Inactivation of the p53 tumor suppressor gene represents the most common genetic abnormality found in human cancer [1]...
  18. MDMX REGULATION OF THE P53 TUMOR SUPPRESSOR PROTEIN
    STEVEN BERBERICH; Fiscal Year: 2000
    ..Inactivation of the p53 tumor suppressor gene represents the most common genetic abnormality found in human cancer [1]...
  19. MDMX REGULATION OF THE P53 TUMOR SUPPRESSOR PROTEIN
    STEVEN BERBERICH; Fiscal Year: 2003
    ..Inactivation of the p53 tumor suppressor gene represents the most common genetic abnormality found in human cancer [1]...
  20. Role of ribosome impairments in X-linked Dyskeratosis Congenita pathogenesis
    Davide Ruggero; Fiscal Year: 2013
    ..translational screen and uncovered the first functional targets of X-DC that include important mRNAs such as p53 and p27...
  21. Role of PALB2 in the DNA damage response and breast cancer suppression
    Bing Xia; Fiscal Year: 2013
    ..will be asked: 1) Does PALB2 inactivation in breast epithelial cells lead to mammary tumor formation? 2) Does p53 play a role in PALB2-mediated tumor suppression, given that p53 and BRCA2 function synergistically to suppress ..
  22. Role of PALB2 in the DNA damage response and breast cancer suppression
    Bing Xia; Fiscal Year: 2012
    ..will be asked: 1) Does PALB2 inactivation in breast epithelial cells lead to mammary tumor formation? 2) Does p53 play a role in PALB2-mediated tumor suppression, given that p53 and BRCA2 function synergistically to suppress ..
  23. Retention of somatic mutations in cancers by changes in pH sensing
    RYAN DANIEL HERNANDEZ; Fiscal Year: 2013
    ..To our knowledge mutations in cancers conferring pH sensing, such as p53-R273H, one of the most commonly occurring mutations we will test, has not been reported, nor has the retention of ..
  24. Functional Analysis of p53 Polymorphic Variants
    Maureen E Murphy; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The central importance of the p53 tumor suppressor gene to human cancer research is best epitomized by the following facts: 1) p53 is the most frequently mutated gene in human cancer;2) p53 is a ..
  25. Functional Analysis of p53 Polymorphic Variants
    Maureen E Murphy; Fiscal Year: 2010
    The central importance of the p53 tumor suppressor gene to human cancer research is best epitomized by the following facts: 1) p53 is the most frequently mutated gene in human cancer;2) p53 is a central signaling molecule in DNA damage-..
  26. Genetic Susceptibility to Nanoparticle-Induced Respiratory Disease
    JAMES CHRISTOPHER BONNER; Fiscal Year: 2013
    ..and mesothelioma is due to reduced expression or impaired functional interaction between COX-2, STAT-1, and p53. The following specific aims will be carried out to test this hypothesis: In Aim 1, we will determine whether COX-2 ..
  27. MECHANISMS OF RADIORESISTANCE AND CELL CYCLE PROGRESSION
    Howard B Lieberman; Fiscal Year: 2013
    ..In addition, RAD9 can, like p53, act as a sequence specific transcription factor...
  28. Regulation of Human Papillomavirus Replication via Cell Signaling Pathways
    ANASTACIA GRIEGO; Fiscal Year: 2013
    ..in EGFR-pathway signaling will result in down regulation of HPV activities in infected cells, leading to recovered p53 and pRb activity, which could render cells more susceptible to chemotherapy and radiation...
  29. Regulations of DNA Alkylation/Deamination Damage Repair
    Rabindra Roy; Fiscal Year: 2013
    ..and repair efficiency depending on sequence context including mutation hotspot sequences in tumor suppressor gene, p53;(2) elucidate the mechanism of recognition of base lesions in MPG-specific BER pathway by analyzing the effect of ..
  30. FOXO1 Inhibition in Genotoxic Stress Response and Prostate Cancer Survival
    Haojie Huang; Fiscal Year: 2013
    ..details as to how damaged cells escape to survive genotoxic stress, especially in the absence of a functional p53, are far from elucidated...
  31. Role of vitamin D receptor in DNA repair
    Dennis H Oh; Fiscal Year: 2013
    ..The dependence of UV-induced VDR expression on the p53 family and on biologically active vitamin D will be measured...
  32. Cell cycle checkpoint defects lead to chronic inflammation in RA
    Thomas M Aune; Fiscal Year: 2013
    ..or other intrinsic pathways, these repair mechanisms;ATR, DNA-PKcs, and ATM, and cell cycle checkpoints, JNK2, p53, p21, p27, CHEK2, RANGAP1 are defective resulting in failure of DNA repair and loss of genomic integrity...
  33. Targeted Degradation of DNA Damage Response Proteins by Autophagy
    Thomas J Begley; Fiscal Year: 2013
    ..Additionally, mTOR inhibition and the induction of autophagy have been linked to p53 and Ataxia-telangiectasia mutated (ATM) signaling after DNA damage...
  34. Genome maintenance functions of CREB/ATF transcription factors
    RANDAL SCOT TIBBETTS; Fiscal Year: 2013
    ..A key aspect of these studies is to test whether the ATM-CREB pathway synergizes with a parallel ATM-p53 pathway to mediate tumor suppression in vivo...
  35. Novel small-molecule inhibitors of Wee1 kinase for medulloblastoma treatment
    Philip Reigan; Fiscal Year: 2013
    ..In addition, we will determine if p53 playsa role in mediating sensitivity to Wee1 inhibition in medulloblastoma and if Wee1 inhibition has therapeutic ..
  36. Characterization of persistent hyperemic foci and their role in photocarcinogenes
    Raymond L Konger; Fiscal Year: 2013
    ..whether the epidermis overlying early hyperemic areas exhibit increased mutations of the key DNA damage regulator, p53, which is known to augment the SASP response...
  37. Molecular Mechanism of Mule in DNA Damage Response and Tumorigenesis
    Qing Zhong; Fiscal Year: 2013
    ..Besides Mcl-1, Mule also ubiquitinates other substrates including p53, thus adding another intriguing link to the apoptosis pathway...
  38. Genome wide analysis of p53 inhibition by high glucose
    Selene Bobadilla; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The tumor suppressor p53 plays a prominent role in cancer and much of human biology...
  39. Epigenetic Regulation of Cell and Tissue Aging
    Nikolai A Timchenko; Fiscal Year: 2013
    ..The RB/p16INK4a, but not p53, pathway regulates the senescence of human melanocytes in culture and melanocytic nevi in vivo...
  40. Biologic and therapeutic relevance of DNMT3A mutations in acute myeloid leukemia
    Olga A Guryanova; Fiscal Year: 2013
    ..Our mechanistic studies point at impaired DNA damage response including attenuation of p53 activation...
  41. Role of p53-mediated unconventional functions in tumor suppression
    Wei Gu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): There is accumulating evidence indicating that p53 is critical in regulation of glycolysis, reactive oxygen species (ROS) production and oxidative stress responses under normal physiological ..
  42. Skin Cancer Chemoprevention by Silibinin: Mechanisms and Efficacy
    Rajesh Agarwal; Fiscal Year: 2013
    ..These initiated cells harbor mutations primarily in p53 tumor suppressor gene that eventually lead to their clonal expansion and formation of skin tumors...
  43. The role of p53 redox-modification in cell fate signaling
    Jason M Held; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The tumor suppressor p53 is a central hub in multiple cancer-related signaling networks that control cell proliferation and cell fate decisions...
  44. Cellular Stress Response Signaling Pathways
    MICHAEL BARRY KASTAN; Fiscal Year: 2013
    ..The induction of p53 protein after DNA damage and other stresses is a critical determinant of cellular outcome after exposure to many ..
  45. Characterization and regulation of the MED17-p53 binding interface.
    Zachary C Poss; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The p53 protein is a transcription factor and tumor suppressor that is frequently mutated in human cancers...
  46. Defining novel pathways that arrest genetically unstable tetraploid cells
    Neil J Ganem; Fiscal Year: 2013
    ..Consequently, cells possess p53-dependent tumor suppression mechanisms that limit the further proliferation of these cells by promoting a durable ..
  47. Telomere induced senescence as a supressor of tumorigenesis
    SANDY S CHANG; Fiscal Year: 2012
    ..In the setting of an intact p53- dependent DNA damage response (DDR) pathway, this instability promotes cellular senescence, a potent tumor ..
  48. Roles of p63 in regulation of miRNA and LincRNA targets in metastatic cancer
    Elsa R Flores; Fiscal Year: 2013
    ..The functions of p63, a p53 family member, are beginning to be understood in contexts in which p53 function has been well established, ..
  49. MITOCHONDRIAL MOTILITY AND INHERITANCE
    Liza A Pon; Fiscal Year: 2013
    ..Since mutation of Chk2 and its upstream (ATM) and downstream (p53) regulators also results in changes in mtDNA content and cell cycle delays in mammalian and human cells, this ..
  50. STATUS OF P53 IN A LFS CANCER PRONE FAMILY
    Esther Chang; Fiscal Year: 1999
    ..The tumor suppressor gene p53 has been shown to frequently altered in a wide variety of sporatic tumors...
  51. Regulation of p53 by BRCA1 in Breast Cancer
    JOY CHIEH YU LIN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The overall frequency of p53 mutation in breast cancer is much lower compared to other cancers despite a high risk of breast cancer associated with p53 germ-line mutations...
  52. The Study of the Circadian Rhythm in p53 Signaling
    LONING NONE FU; Fiscal Year: 2013
    ..We have reported previously that the expression of c-myc and p53 follows a circadian rhythm in vivo and loss of function in the circadian genes, Period1 and 2, leads to neoplastic ..
  53. Re-replication of chromosomes and cancer
    Anindya Dutta; Fiscal Year: 2013
    ..checkpoint pathways used several genes whose mutations predispose individuals to genomic instability and cancer: p53, BrCa1 and the Fanconi Anemia proteins...
  54. Protein Kinase Signaling and Cell Cycle Control
    Michael B Yaffe; Fiscal Year: 2013
    ..a third DNA damage response pathway mediated by p38MAPK and MAPKAP Kinase-2 (MK2) that is absolutely essential for p53-defective tumor cells to survive after DNA damage...
  55. Mechanisms of DNA damage-induced, p53-dependent repression of the Cdc25C Phosphat
    Luis A Carvajal; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The tumor suppressor p53 is the most commonly mutated gene found in human cancers [3]. It plays a vital role in guarding mammalian cells against tumorigenesis [22,23]...
  56. Nuclear Accumulation of Cyclin D1 and Oncogenesis
    JOHN ALAN DIEHL; Fiscal Year: 2013
    ..to human MCL, is genomically unstable and exhibits a paradox associated with human disease;retention of wild type p53. Because p53 functions to limit expansion of genomically unstable cells, MCL must bypass p53 without selection for ..
  57. Gain of function mutant p53 in telomere uncapping-driven breast tumorigenesis
    Yibin Deng; Fiscal Year: 2013
    ..the other hand, recent systematic genomic analyses in human breast carcinomas have revealed that tumor suppressor p53 is the most commonly alerted gene, predominantly through missense mutations that result in accumulation of mutant ..
  58. The Role of ATF3 in the DNA Damage Response
    Chunhong Yan; Fiscal Year: 2013
    ..We therefore hypothesize that these interactions could be behind the mechanisms by which ATF3 regulates p53 tumor suppressor activity in the DNA damage response...
  59. Selective Sensitization of Pancreatic Cancer to Therapy by Chk1 and PARP1 Inhibit
    Meredith A Morgan; Fiscal Year: 2013
    ..Importantly, Chk1 inhibition preferentially sensitizes p53-mutant tumor cells and K-Ras mutation may also confer sensitivity to Chk1 inhibition...
  60. Regulation of Mdmx stability and subcellular localization by ubiquitination
    Wei Gu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The p53 tumor suppressor acts as the major sensor for a regulatory circuit that monitors signaling pathways from diverse sources, including DNA damage, oncogenic events, ribosomal stress and others ..
  61. REGULATION OF SKELETAL MUSCLE METABOLISM
    Leonard S Jefferson; Fiscal Year: 2013
    ..perform a detailed analysis of components of the mTORC1 signaling pathway, including novel upstream inputs such as p53 and Sestrin 1, 2, and 3, as well as selected novel regulatory mechanisms that mediate control of protein synthesis, ..
  62. Spindle Assembly Checkpoint, Chromosome Stability, and Cancer
    Pumin Zhang; Fiscal Year: 2013
    ..scale, one must ask: do cells mount a response to it? Our previous work demonstrated that aneuploidy could activate p53 and cause apoptotic cell death...
  63. The SMC5/6 Complex - DNA Damage Response Regulation Ensures Meiotic Fidelity
    Philip W Jordan; Fiscal Year: 2013
    ..The BAT3-EP300 complex is required for the activation of a TRP53-mediated DNA damage response...
  64. SBIR PHASE II: SITE-SPECIFIC ANTIBODIES FOR GLCNACYLATED PROTEINS IN CANCER
    Hyesook Kim; Fiscal Year: 2013
    ..O-GlcNAcylation of c-myc proteins induces ubiquitin-dependent c-myc degradation. GlcNAcylation of p53 prevents p53 degradation and stabilizes p53 proteins, which are beneficial in cancer cells by arresting cell growth ..
  65. Wwox and Fhit loss and the DNA damage response in breast cancer subtypes
    Kay Huebner; Fiscal Year: 2013
    ..DNA damage response (DDR) proteins ([unreadable]H2AX, pChk2, p53) were expressed highly significantly more in TN and basal-like tumors...
  66. Regulation of p53 function by Daxx
    Xiaolu Yang; Fiscal Year: 2012
    ..this project is to elucidate the role of death domain-associated protein (Daxx) in regulating the tumor suppressor p53. p53 induces apoptosis, cell cycle, or senescence in response to a variety of stresses such as DNA damage and the ..
  67. Modulation of p53 induction by targeting cap-dependent translation in cancer
    Da Qing Yang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The p53 tumor suppressor protein protects cells against malignant transformation through induction of either cell cycle arrest or apoptosis...
  68. Role of NIAM, A Putative Cancer Gene, in Chromosomal Instability and Glioblastoma
    SARA MARIE FRANCIS-REED; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Uncontrolled cellular proliferation, altered p53 tumor suppressor signaling, and chromosomal instability (CIN) are signature features of tumorigenesis...
  69. Regulation of Mutant P53 Expression and Oncogenic Activity
    Xinbin Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mutation of p53 is the most frequent genetic alteration in human cancer. The majority of tumor- derived p53 mutations is missense mutation and clustered within the central DNA-binding domain...
  70. A Strategy for Reactivating p53 in Cancer Stem Cells Using a Novel HdmX Inhibitor
    David Wald; Fiscal Year: 2013
    ..A critical cell cycle checkpoint regulator is the p53 tumor suppressor, which is kept in check in normal cells by HdmX and Hdm2...
  71. Acute Kidney Injury by Cisplatin and Renoprotective Strategies
    Zheng Dong; Fiscal Year: 2013
    ..has revealed several upstream signaling pathways in tubular damage during cisplatin-AKI, including Src, MAPK, p53 and a rapid DNA damage response...
  72. Alternative Mechanisms to Inactivate p53 During Oncogenesis
    Zhiyuan Shen; Fiscal Year: 2013
    ..Based on these studies, we hypothesize that BCCIP defect represents a new mechanism to inactivate the p53 tumor suppressor activity, and plays a role in breast cancer development...
  73. Alternative Mechanisms to Inactivate p53 During Oncogenesis
    Zhiyuan Shen; Fiscal Year: 2013
    ..Based on these studies, we hypothesize that BCCIP defect represents a new mechanism to inactivate the p53 tumor suppressor activity, and plays a role in breast cancer development...
  74. Alternative Mechanisms to Inactivate p53 During Oncogenesis
    Zhiyuan Shen; Fiscal Year: 2012
    ..Based on these studies, we hypothesize that BCCIP defect represents a new mechanism to inactivate the p53 tumor suppressor activity, and plays a role in breast cancer development...
  75. Life Cycle of Human Papillomaviruses
    Laimonis A Laimins; Fiscal Year: 2013
    ..Additional important activities identified for E6 include blocking of p300 acetylation of p53 and activation of p63 upon differentiation...
  76. MCAV in Organ-Confined Bladder CA based on p53 Status
    Richard Cote; Fiscal Year: 2006
    This is a renewal application to our on-going "p53/MVAC" study. Tumor progression in transitional cell carcinoma (TCC) of the urinary bladder is believed to occur through a multistep accumulation of genetic alterations...
  77. MCAV in Organ-Confined Bladder CA based on p53 Status
    Richard Cote; Fiscal Year: 2005
    This is a renewal application to our on-going "p53/MVAC" study. Tumor progression in transitional cell carcinoma (TCC) of the urinary bladder is believed to occur through a multistep accumulation of genetic alterations...
  78. MCAV in Organ-Confined Bladder CA based on p53 Status
    Richard Cote; Fiscal Year: 2004
    This is a renewal application to our on-going "p53/MVAC" study. Tumor progression in transitional cell carcinoma (TCC) of the urinary bladder is believed to occur through a multistep accumulation of genetic alterations...
  79. MCAV in Organ-Confined Bladder CA based on p53 Status
    Richard Cote; Fiscal Year: 2003
    This is a renewal application to our on-going "p53/MVAC" study. Tumor progression in transitional cell carcinoma (TCC) of the urinary bladder is believed to occur through a multistep accumulation of genetic alterations...
  80. REGULATION OF P53 EXPRESSION BY C7 TRANSCRIPTION FACTOR
    David Strayer; Fiscal Year: 1999
    DESCRIPTION: This is an application to study control of p53 transcription using a unique new system...
  81. DEPENDENCE OF P53 ON THIOL MAINTENANCE PROTEINS
    Gary Merrill; Fiscal Year: 2000
    Stimulation of transcription by the human tumor suppressor protein p53 is compromised in yeast lacking the enzyme thioredoxin reductase (Trr1). The result suggests that p53 is prone to oxidative inactivation...
  82. DEPENDENCE OF P53 ON THIOL MAINTENANCE PROTEINS
    Gary Merrill; Fiscal Year: 2001
    Stimulation of transcription by the human tumor suppressor protein p53 is compromised in yeast lacking the enzyme thioredoxin reductase (Trr1). The result suggests that p53 is prone to oxidative inactivation...
  83. DEPENDENCE OF P53 ON THIOL MAINTENANCE PROTEINS
    Gary Merrill; Fiscal Year: 1999
    Stimulation of transcription by the human tumor suppressor protein p53 is compromised in yeast lacking the enzyme thioredoxin reductase (Trr1). The result suggests that p53 is prone to oxidative inactivation...
  84. Gene Delivery of P53 in a Tumor-bearing Mouse Model
    A Mixson; Fiscal Year: 2004
    Systemic gene delivery of p53 with cationic liposomes has been shown to reduce tumor growth in pre-clinical models...
  85. Gene Delivery of P53 in a Tumor-bearing Mouse Model
    A Mixson; Fiscal Year: 2006
    Systemic gene delivery of p53 with cationic liposomes has been shown to reduce tumor growth in pre-clinical models...
  86. The effect of p53 signaling on the metabolism and therapeutic response of glioma
    Tracy Richmond McKnight; Fiscal Year: 2010
    ..the metabolic profile and therapeutic responsiveness of glioma cells with functional and non-functional p53 tumor suppressor protein to test the hypothesis that cells with non-functional p53 will have lower creatine+phosphocreatine ..
  87. Gene Delivery of P53 in a Tumor-bearing Mouse Model
    A Mixson; Fiscal Year: 2005
    Systemic gene delivery of p53 with cationic liposomes has been shown to reduce tumor growth in pre-clinical models...
  88. Gene Delivery of P53 in a Tumor-bearing Mouse Model
    ARCHIBALD MIXSON; Fiscal Year: 2007
    Systemic gene delivery of p53 with cationic liposomes has been shown to reduce tumor growth in pre-clinical models...
  89. HTLV I Tax1 protein chemosensitization of p53 mutant tumors
    Gary M Kupfer; Fiscal Year: 2010
    Our work on human T cell leukemia virus I (HTLV I) has revealed that the oncoprotein Tax, when introduced into p53 null cells, causes apoptosis upon exposure to UV damage, resulting in increased cell death...
  90. Skin Cancer Chemoprevention by Silibinin: Mechanisms and Efficacy
    Rajesh Agarwal; Fiscal Year: 2012
    ..These initiated cells harbor mutations primarily in p53 tumor suppressor gene that eventually lead to their clonal expansion and formation of skin tumors...
  91. Skin Cancer Chemoprevention by Silibinin: Mechanisms and Efficacy
    Rajesh Agarwal; Fiscal Year: 2010
    ..These initiated cells harbor mutations primarily in p53 tumor suppressor gene that eventually lead to their clonal expansion and formation of skin tumors...
  92. Mechanism of p53-Mediated Tumor Suppression
    Xinbin Chen; Fiscal Year: 2009
    b>p53 tumor suppressor is a transcription factor and can be activated in response to various stress signals, including DNA damage, oncogene activation, and hypoxia...
  93. p53-Independent Cell Death Signaling by Mitomycin DNA Adducts
    JILL E BARGONETTI; Fiscal Year: 2010
    The need to identify drugs and pathways that induce cell death independently of p53 deserves substantial attention...
  94. p53-Independent Cell Death Signaling by Mitomycin DNA Adducts
    Jill Bargonetti; Fiscal Year: 2009
    The need to identify drugs and pathways that induce cell death independently of p53 deserves substantial attention...
  95. Mechanisms of p53 activation in tumorsuppression
    Wei Gu; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: The p53 tumor suppressor is mutated in every type of human cancers...
  96. Mechanisms of p53 activation in tumorsuppression
    Wei Gu; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The p53 tumor suppressor is mutated in every type of human cancers...
  97. Study of a FACTp140-SSRP1-associated p53 Kinase
    Hua Lu; Fiscal Year: 2004
    ..of this proposal is to understand the molecular and biochemical basis underlying the regulation of the p53 tumor suppressor protein in mammalian systems...
  98. Study of a FACTp140-SSRP1-associated p53 Kinase
    Hua Lu; Fiscal Year: 2006
    ..of this proposal is to understand the molecular and biochemical basis underlying the regulation of the p53 tumor suppressor protein in mammalian systems...
  99. HYPOXIA AND GENE REPRESSION
    Amato J Giaccia; Fiscal Year: 2010
    ..The tumor suppressor protein p53 induces rapid apoptosis in response to oxygen concentrations that induce an S-phase arrest...
  100. Study of a FACTp140-SSRP1-associated p53 Kinase
    Hua Lu; Fiscal Year: 2003
    ..of this proposal is to understand the molecular and biochemical basis underlying the regulation of the p53 tumor suppressor protein in mammalian systems...