p53

Summary

Gene Symbol: p53
Description: tumor protein p53
Alias: BCC7, LFS1, P53, TRP53, antigen NY-CO-13, cellular tumor antigen p53, mutant tumor protein 53, p53 tumor suppressor, phosphoprotein p53, transformation-related protein 53, tumor protein 53
Species: human

Top Publications

  1. doi p53 polymorphisms: cancer implications
    Catherine Whibley
    Leeds Institute of Genetics, Health and Therapeutics, LIGHT Laboratories, University of Leeds, Leeds, LS2 9JT, UK
    Nat Rev Cancer 9:95-107. 2009
  2. doi p53 mutations in cancer
    Patricia A J Muller
    The Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow, G61 1BD, UK
    Nat Cell Biol 15:2-8. 2013
  3. doi Blinded by the Light: The Growing Complexity of p53
    Karen H Vousden
    The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Cell 137:413-31. 2009
  4. ncbi Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    M Serrano
    Cold Spring Harbor Laboratory, New York 11724, USA
    Cell 88:593-602. 1997
  5. doi Mutant p53 drives invasion by promoting integrin recycling
    Patricia A J Muller
    The Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Cell 139:1327-41. 2009
  6. ncbi Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
    W Gu
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
    Cell 90:595-606. 1997
  7. pmc Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
    Tsung Cheng Chang
    The McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell 26:745-52. 2007
  8. pmc A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response
    Maite Huarte
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Cell 142:409-19. 2010
  9. pmc TP53 mutations in human cancers: origins, consequences, and clinical use
    Magali Olivier
    Group of Molecular Carcinogenesis, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Cold Spring Harb Perspect Biol 2:a001008. 2010
  10. pmc p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
    Taewan Kim
    Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, 2 Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, OH 43210, USA
    J Exp Med 208:875-83. 2011

Research Grants

Detail Information

Publications397 found, 100 shown here

  1. doi p53 polymorphisms: cancer implications
    Catherine Whibley
    Leeds Institute of Genetics, Health and Therapeutics, LIGHT Laboratories, University of Leeds, Leeds, LS2 9JT, UK
    Nat Rev Cancer 9:95-107. 2009
    The normal functioning of p53 is a potent barrier to cancer...
  2. doi p53 mutations in cancer
    Patricia A J Muller
    The Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow, G61 1BD, UK
    Nat Cell Biol 15:2-8. 2013
    In the past fifteen years, it has become apparent that tumour-associated p53 mutations can provoke activities that are different to those resulting from simply loss of wild-type tumour-suppressing p53 function...
  3. doi Blinded by the Light: The Growing Complexity of p53
    Karen H Vousden
    The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Cell 137:413-31. 2009
    While the tumor suppressor functions of p53 have long been recognized, the contribution of p53 to numerous other aspects of disease and normal life is only now being appreciated...
  4. ncbi Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    M Serrano
    Cold Spring Harbor Laboratory, New York 11724, USA
    Cell 88:593-602. 1997
    ..of primary cells by ras requires either a cooperating oncogene or the inactivation of tumor suppressors such as p53 or p16...
  5. doi Mutant p53 drives invasion by promoting integrin recycling
    Patricia A J Muller
    The Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Cell 139:1327-41. 2009
    b>p53 is a tumor suppressor protein whose function is frequently lost in cancers through missense mutations within the Tp53 gene...
  6. ncbi Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
    W Gu
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
    Cell 90:595-606. 1997
    The tumor suppressor p53 exerts antiproliferation effects through its ability to function as a sequence-specific DNA-binding transcription factor. Here, we demonstrate that p53 can be modified by acetylation both in vivo and in vitro...
  7. pmc Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
    Tsung Cheng Chang
    The McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell 26:745-52. 2007
    The p53 tumor suppressor protein is a critical regulator of the cellular response to cancer-initiating insults such as genotoxic stress...
  8. pmc A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response
    Maite Huarte
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Cell 142:409-19. 2010
    ..Here, we report the identification of lincRNAs that are regulated by p53. One of these lincRNAs (lincRNA-p21) serves as a repressor in p53-dependent transcriptional responses...
  9. pmc TP53 mutations in human cancers: origins, consequences, and clinical use
    Magali Olivier
    Group of Molecular Carcinogenesis, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Cold Spring Harb Perspect Biol 2:a001008. 2010
    ..All mutations found in human cancers are compiled in the IARC TP53 Database (http://www-p53.iarc.fr/)...
  10. pmc p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
    Taewan Kim
    Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, 2 Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, OH 43210, USA
    J Exp Med 208:875-83. 2011
    b>p53 suppresses tumor progression and metastasis. Epithelial-mesenchymal transition (EMT) is a key process in tumor progression and metastasis. The transcription factors ZEB1 and ZEB2 promote EMT...
  11. ncbi Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2
    Thomas G Hofmann
    Division of Immunochemistry G0200 German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nat Cell Biol 4:1-10. 2002
    Transcriptional activity of p53, a central regulatory switch in a network controlling cell proliferation and apoptosis, is modulated by protein stability and post-translational modifications including phosphorylation and acetylation...
  12. pmc Regulation of autophagy by cytoplasmic p53
    Ezgi Tasdemir
    INSERM, U848, France
    Nat Cell Biol 10:676-87. 2008
    Multiple cellular stressors, including activation of the tumour suppressor p53, can stimulate autophagy...
  13. ncbi p53-mediated activation of miRNA34 candidate tumor-suppressor genes
    Guido T Bommer
    Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109 2200, USA
    Curr Biol 17:1298-307. 2007
    In response to varied cell stress signals, the p53 tumor-suppressor protein activates a multitude of genes encoding proteins with functions in cell-cycle control, DNA repair, senescence, and apoptosis...
  14. pmc p53 dynamics control cell fate
    Jeremy E Purvis
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 336:1440-4. 2012
    ..The dynamic behavior of the tumor suppressor p53 varies depending on the stimulus; in response to double-strand DNA breaks, it shows a series of repeated pulses...
  15. ncbi Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis
    Yi Tang
    Institute for Cancer Genetics, Surgeons, Columbia University, 1150 St Nicholas Ave, New York, New York 10032, USA
    Mol Cell 24:827-39. 2006
    Upon DNA damage and other types of stress, p53 induces either cell-cycle arrest or apoptosis depending on the cellular context...
  16. ncbi Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis
    Gabriella D'Orazi
    Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Via delle Messi d Oro 156, 00158 Rome, Italy
    Nat Cell Biol 4:11-9. 2002
    Phosphorylation of p53 at Ser 46 was shown to regulate p53 apoptotic activity...
  17. ncbi hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
    H Vaziri
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 107:149-59. 2001
    DNA damage-induced acetylation of p53 protein leads to its activation and either growth arrest or apoptosis. We show here that the protein product of the gene hSIR2(SIRT1), the human homolog of the S...
  18. ncbi Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    R Honda
    School of Life Science, Tokyo University of Pharmacy and Life Science, Japan
    FEBS Lett 420:25-7. 1997
    The tumor suppressor p53 is degraded by the ubiquitin-proteasome system. p53 was polyubiquitinated in the presence of E1, UbcH5 as E2 and MDM2 oncoprotein...
  19. ncbi Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
    D Malkin
    Division of Molecular Genetics, Massachusetts General Hospital Cancer Center, Charlestown 02129
    Science 250:1233-8. 1990
    ..The alternative approach was to select the most plausible candidate gene. The tumor suppressor gene, p53, was studied because of previous indications that this gene is inactivated in the sporadic (nonfamilial) forms of ..
  20. ncbi Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest
    Valery Tarasov
    Molecular Oncology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Cell Cycle 6:1586-93. 2007
    In a genome-wide screen for microRNAs regulated by the transcription factor encoded by the p53 tumor suppressor gene we found that after p53-activation the abundance of thirty-four miRNAs was significantly increased, whereas sixteen ..
  21. pmc p53 post-translational modification: deregulated in tumorigenesis
    Chao Dai
    Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, 1130 St Nicholas Avenue, New York, NY 10032, USA
    Trends Mol Med 16:528-36. 2010
    The p53 tumor suppressor protein has well-established roles in monitoring various types of stress signals by activating specific transcriptional targets that control cell cycle arrest and apoptosis, although some activities are also ..
  22. pmc Acetylation is indispensable for p53 activation
    Yi Tang
    Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell 133:612-26. 2008
    The activation of the tumor suppressor p53 facilitates the cellular response to genotoxic stress; however, the p53 response can only be executed if its interaction with its inhibitor Mdm2 is abolished...
  23. doi A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis
    Maddalena Adorno
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padua School of Medicine, viale Colombo 3, 35100 Padua, Italy
    Cell 137:87-98. 2009
    ..Here, we show that TGFbeta-dependent cell migration, invasion and metastasis are empowered by mutant-p53 and opposed by p63...
  24. ncbi DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    S Y Shieh
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Cell 91:325-34. 1997
    DNA-damaging agents signal to p53 through as yet unidentified posttranscriptional mechanisms...
  25. pmc Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage
    Eric Batchelor
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 30:277-89. 2008
    DNA damage initiates a series of p53 pulses. Although much is known about the interactions surrounding p53, little is known about which interactions contribute to p53's dynamical behavior...
  26. pmc Acetylation of the p53 DNA-binding domain regulates apoptosis induction
    Stephen M Sykes
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Mol Cell 24:841-51. 2006
    The ability of p53 to induce apoptosis plays an important role in tumor suppression. Here, we describe a previously unknown posttranslational modification of the DNA-binding domain of p53...
  27. ncbi ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    Y Zhang
    Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, 27599 3280, USA
    Cell 92:725-34. 1998
    ..p16INK4 binds to and inhibits the activity of CDK4 and CDK6, and ARF arrests the cell cycle in a p53-dependent manner. We show here that ARF binds to MDM2 and promotes the rapid degradation of MDM2...
  28. pmc A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53
    Surojit Sur
    The Howard Hughes Medical Institute and The Ludwig Center for Cancer Genetics and Therapeutics, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 106:3964-9. 2009
    ..This hypothesis was validated by demonstrating that stressed cancer cells without WT TP53 alleles were highly sensitive to PLK1 inhibitors, both in vivo and in vitro...
  29. pmc Mutant p53 gain-of-function in cancer
    Moshe Oren
    Department of Molecular Cell Biology, The Weizmann Institute, Rehovot 76100, Israel
    Cold Spring Harb Perspect Biol 2:a001107. 2010
    In its wild-type form, p53 is a major tumor suppressor whose function is critical for protection against cancer. Many human tumors carry missense mutations in the TP53 gene, encoding p53...
  30. ncbi Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
    Natalia Issaeva
    Microbiology and Tumor Biology Center, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Nat Med 10:1321-8. 2004
    In tumors that retain wild-type p53, its tumor-suppressor function is often impaired as a result of the deregulation of HDM-2, which binds to p53 and targets it for proteasomal degradation...
  31. ncbi Acetylation of p53 inhibits its ubiquitination by Mdm2
    Muyang Li
    Institute for Cancer Genetics, and Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 277:50607-11. 2002
    In response to DNA damage, the activity of the p53 tumor suppressor is modulated by protein stabilization and post-translational modifications including acetylation...
  32. pmc Wild-type p53 controls cell motility and invasion by dual regulation of MET expression
    Chang Il Hwang
    Department of Biomedical Sciences, Microarray Core Facility, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 108:14240-5. 2011
    Recent observations suggest that p53 mutations are responsible not only for growth of primary tumors but also for their dissemination...
  33. doi Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity
    Saifeng Wang
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences CAS, Beijing, PR China
    Hepatology 55:730-41. 2012
    ..and electrophoretic mobility shift assay, we further demonstrated that cyclin G(1) specifically interacted with p53, and this interaction blocked the specific binding of p53 to HBV enhancer elements and simultaneously abrogated p53-..
  34. ncbi Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5
    Mu Shui Dai
    Department of Biochemistry and Molecular Biology, School of Medicine, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Biol Chem 279:44475-82. 2004
    ..Both L11 and L23 have been shown to activate p53 by inhibiting MDM2-mediated p53 suppression. Here we have shown that L5 also activates p53...
  35. ncbi p53 is regulated by the lysine demethylase LSD1
    Jing Huang
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nature 449:105-8. 2007
    b>p53, the tumour suppressor and transcriptional activator, is regulated by numerous post-translational modifications, including lysine methylation...
  36. pmc Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53
    Ting Wang
    Center for Biomolecular Science and Engineering, and Howard Hughes Medical Institute, University of California, Santa Cruz, CA 95064, USA
    Proc Natl Acad Sci U S A 104:18613-8. 2007
    ..retrovirus (ERV) retroelements impact considerably the transcriptional network of human tumor suppressor protein p53. A total of 1,509 of approximately 319,000 human ERV LTR regions have a near-perfect p53 DNA binding site...
  37. ncbi Mono- versus polyubiquitination: differential control of p53 fate by Mdm2
    Muyang Li
    Institute for Cancer Genetics and Department of Pathology, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Science 302:1972-5. 2003
    Although Mdm2-mediated ubiquitination is essential for both degradation and nuclear export of p53, the molecular basis for the differential effects of Mdm2 remains unknown...
  38. ncbi Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
    Jerry E Chipuk
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Science 303:1010-4. 2004
    The tumor suppressor p53 exerts its anti-neoplastic activity primarily through the induction of apoptosis...
  39. ncbi Transcriptional activation of miR-34a contributes to p53-mediated apoptosis
    Nina Raver-Shapira
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell 26:731-43. 2007
    b>p53 is a potent tumor suppressor, whose biological effects are largely due to its function as a transcriptional regulator...
  40. ncbi TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes
    A Petitjean
    International Agency for Research on Cancer, Lyon, France
    Oncogene 26:2157-65. 2007
    ..New data on mutant p53 protein function, cancer phenotype and prognosis have recently been integrated in the International Agency for ..
  41. pmc P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis
    Munekazu Yamakuchi
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 107:6334-9. 2010
    ..Here we show that p53 regulates hypoxic signaling through the transcriptional regulation of microRNA-107 (miR-107)...
  42. pmc p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs
    Chun Ju Chang
    Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Nat Cell Biol 13:317-23. 2011
    ..Here, using genomic approaches, we show that tumour suppressor p53 has a role in regulating both EMT and EMT-associated stem cell properties through transcriptional activation of the ..
  43. pmc Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary
    Ahmed Ashour Ahmed
    Functional Genomics of Ovarian Cancer Laboratory, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK
    J Pathol 221:49-56. 2010
    ..7% (n = 119/123) of HGPSC cases. Molecular and pathological review of mutation-negative cases showed evidence of p53 dysfunction associated with copy number gain of MDM2 or MDM4, or indicated the exclusion of samples as being low-..
  44. pmc p53 represses c-Myc through induction of the tumor suppressor miR-145
    Mohit Sachdeva
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Proc Natl Acad Sci U S A 106:3207-12. 2009
    The tumor suppressor p53 negatively regulates a number of genes, including the proto-oncogene c-Myc, in addition to activating many other genes. One mechanism of the p53-mediated c-Myc repression may involve transcriptional regulation...
  45. ncbi p53 has a direct apoptogenic role at the mitochondria
    Motohiro Mihara
    Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA
    Mol Cell 11:577-90. 2003
    b>p53 induces apoptosis by target gene regulation and transcription-independent signaling. However, a mechanism for the latter was unknown...
  46. pmc Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
    Jennifer P Morton
    Beatson Institute for Cancer Research, Glasgow G61 1BD, United Kingdom
    Proc Natl Acad Sci U S A 107:246-51. 2010
    ..In this study we elucidate the functions of mutant p53 (Trp53(R172H)), compared to knockout p53 (Trp53(fl)), in a mouse model of PDAC...
  47. pmc Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
    Sawako Suzuki
    Department of Clinical Cell Biology and Division of Endocrinology and Metabolism, Chiba University Graduate School of Medicine, Chiba shi, Chiba 260 8670, Japan
    Proc Natl Acad Sci U S A 107:7461-6. 2010
    ..Thus, our results provide evidence for a unique metabolic role for p53, linking glutamine metabolism, energy, and ROS homeostasis, which may contribute to p53 tumor suppressor function.
  48. pmc Paradoxical suppression of cellular senescence by p53
    Zoya N Demidenko
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Proc Natl Acad Sci U S A 107:9660-4. 2010
    The tumor suppressor p53 is a canonical inducer of cellular senescence (irreversible loss of proliferative potential and senescent morphology)...
  49. pmc Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells
    Alexander Loewer
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 142:89-100. 2010
    The tumor suppressor p53 is activated by stress and leads to cellular outcomes such as apoptosis and cell-cycle arrest. Its activation must be highly sensitive to ensure that cells react appropriately to damage...
  50. ncbi DNA damage-induced activation of p53 by the checkpoint kinase Chk2
    A Hirao
    The Amgen Institute, Ontario Cancer Institute, and Departments of Medical Biophysics and Immunology, University of Toronto, 620 University Avenue, Suite 706, Toronto, Ontario, M5G 2C1, Canada
    Science 287:1824-7. 2000
    ..Chk2-/- thymocytes were resistant to DNA damage-induced apoptosis. Chk2-/- cells were defective for p53 stabilization and for induction of p53-dependent transcripts such as p21 in response to gamma irradiation...
  51. pmc p53 regulates nuclear GSK-3 levels through miR-34-mediated Axin2 suppression in colorectal cancer cells
    Nam Hee Kim
    Department of Oral Pathology, Oral Cancer Research Institute, College of Dentistry, Yonsei University, Seoul, Korea
    Cell Cycle 12:1578-87. 2013
    b>p53 is a bona fide tumor suppressor gene whose loss of function marks the most common genetic alteration in human malignancy...
  52. pmc p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells
    Abhinav K Jain
    Program in Genes and Development, Center for Stem Cell and Development Biology, Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    PLoS Biol 10:e1001268. 2012
    Multiple studies show that tumor suppressor p53 is a barrier to dedifferentiation; whether this is strictly due to repression of proliferation remains a subject of debate...
  53. ncbi p53 mutations in human cancers
    M Hollstein
    Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Science 253:49-53. 1991
    Mutations in the evolutionarily conserved codons of the p53 tumor suppressor gene are common in diverse types of human cancer...
  54. pmc p53 mutant breast cancer patients expressing p53γ have as good a prognosis as wild-type p53 breast cancer patients
    Jean Christophe Bourdon
    Centre for Oncology and Molecular Medicine, Inserm European Associated Laboratory, University of Dundee, Dundee, DD1 9SY, UK
    Breast Cancer Res 13:R7. 2011
    Normal function of the p53 network is lost in most cancers, often through p53 mutation. The clinical impact of p53 mutations in breast cancer remains uncertain, especially where p53 isoforms may modify the effects of these p53 mutations.
  55. doi Beyond Li Fraumeni Syndrome: clinical characteristics of families with p53 germline mutations
    Kelly D Gonzalez
    Departments of Molecular Diagnosis, Molecular Genetics, Clinical Cancer Genetics, and Information Sciences, and the Bioinformatics Group, City of Hope, Duarte, CA 91010 0269, USA
    J Clin Oncol 27:1250-6. 2009
    A clinical testing cohort was used to gain a broader understanding of the spectrum of tumors associated with germline p53 mutations to aid clinicians in identifying high-risk families.
  56. pmc MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation
    Wei Fu
    Department of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    J Biol Chem 284:13987-4000. 2009
    ..In cells stably expressing a temperature-sensitive p53 mutant, activation of p53 by shifting to permissive temperatures leads to MDM2 induction and degradation of ..
  57. pmc Expression signatures of TP53 mutations in serous ovarian cancers
    Marcus Q Bernardini
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Toronto, 600 University Avenue, Toronto, Ontario M5G2M9, Canada
    BMC Cancer 10:237. 2010
    ..Mutations in the TP53 gene are extremely common and occur very early in the progression of serous ovarian cancers. Gene expression patterns that relate to mutational status may provide insight into the etiology and biology of the disease...
  58. pmc The p53 orchestra: Mdm2 and Mdmx set the tone
    Mark Wade
    Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Trends Cell Biol 20:299-309. 2010
    The activities of p53 cover diverse aspects of cell biology, including cell cycle control, apoptosis, metabolism, fertility, differentiation and cellular reprogramming...
  59. ncbi The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer
    Magali Olivier
    IARC, Lyon, France
    Clin Cancer Res 12:1157-67. 2006
    ..These results, obtained on the largest series analyzed thus far, show that TP53 mutations identified by gene sequencing have an independent prognostic value in breast cancer and could have potential uses in clinical practice...
  60. pmc Regulation of p53 target gene expression by peptidylarginine deiminase 4
    Pingxin Li
    Center for Gene Regulation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    Mol Cell Biol 28:4745-58. 2008
    Histone Arg methylation has been correlated with transcriptional activation of p53 target genes. However, whether this modification is reversed to repress the expression of p53 target genes is unclear...
  61. ncbi p53 and breast cancer, an update
    Marc Lacroix
    Laboratoire Jean Claude Heuson de Cancérologie Mammaire, Institut Jules Bordet Université Libre de Bruxelles, 127 boulevard de Waterloo, B 1000 Bruxelles, Belgium
    Endocr Relat Cancer 13:293-325. 2006
    b>p53 plays a key role in mediating cell response to various stresses, mainly by inducing or repressing a number of genes involved in cell cycle arrest, senescence, apoptosis, DNA repair, and angiogenesis...
  62. pmc The combined status of ATM and p53 link tumor development with therapeutic response
    Hai Jiang
    The Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 23:1895-909. 2009
    ..Specifically, evaluation of the combined status of ATM and p53, two commonly mutated tumor suppressor genes, can help to predict the clinical response to genotoxic chemotherapies...
  63. ncbi Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation
    Silvia Di Agostino
    Experimental Oncology Department, Istituto Regina Elena, Via delle Messi d Oro 156, 00158 Rome, Italy
    Cancer Cell 10:191-202. 2006
    This article investigates the mechanistic aspects of mutant p53 "gain of function" in response to DNA damage. We show that mutant forms of p53 protein interact with NF-Y...
  64. pmc p53 isoforms can regulate p53 transcriptional activity
    Jean Christophe Bourdon
    Department of Surgery, Cancer Research UK Cell Transformation Research Group, University of Dundee, Ninewells Hospital, Scotland, UK
    Genes Dev 19:2122-37. 2005
    The recently discovered p53-related genes, p73 and p63, express multiple splice variants and N-terminally truncated forms initiated from an alternative promoter in intron 3...
  65. pmc Negative regulation of tumor suppressor p53 by microRNA miR-504
    Wenwei Hu
    Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA
    Mol Cell 38:689-99. 2010
    Tumor suppressor p53 plays a central role in tumor prevention. p53 protein levels and activity are under a tight and complex regulation in cells to maintain the proper function of p53...
  66. doi Modulation of microRNA processing by p53
    Hiroshi I Suzuki
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 460:529-33. 2009
    ..Here we show that a central tumour suppressor, p53, enhances the post-transcriptional maturation of several miRNAs with growth-suppressive function, including miR-16-..
  67. pmc A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition
    Nam Hee Kim
    Department of Oral Pathology, Oral Cancer Research Institute, College of Dentistry, Yonsei University, Seoul 120 752, South Korea
    J Cell Biol 195:417-33. 2011
    ..Herein, we demonstrate that p53 loss-of-function or mutation promotes cancer cell EMT by de-repressing Snail1 protein expression and activity...
  68. ncbi Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
    Muyang Li
    Institute for Cancer Genetics, and Department of Pathology, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, New York, New York 10032, USA
    Nature 416:648-53. 2002
    The p53 tumour suppressor is a short-lived protein that is maintained at low levels in normal cells by Mdm2-mediated ubiquitination and subsequent proteolysis. Stabilization of p53 is crucial for its tumour suppressor function...
  69. doi Cross talk between stimulated NF-kappaB and the tumor suppressor p53
    G Schneider
    Klinikum rechts der Isar, II, Medizinische Klinik, Technische Universitat Munchen, Munchen, Germany
    Oncogene 29:2795-806. 2010
    Nuclear factor-kappaB (NF-kappaB) and p53 critically determine cancer development and progression. Defining the cross talk between these transcription factors can expand our knowledge on molecular mechanisms of tumorigenesis...
  70. ncbi Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
    J I Ju Leu
    Department of Genetics, University of Pennsylvania School of Medicine, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Nat Cell Biol 6:443-50. 2004
    The tumour suppressor activity of the p53 protein has been explained by its ability to induce apoptosis in response to a variety of cellular stresses...
  71. ncbi Deacetylation of p53 modulates its effect on cell growth and apoptosis
    J Luo
    Institute of Cancer Genetics, and Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Nature 408:377-81. 2000
    The p53 tumour suppressor is a transcriptional factor whose activity is modulated by protein stability and post-translational modifications including acetylation...
  72. ncbi Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
    Vladimir J N Bykov
    Karolinska Institutet, Department of Oncology Pathology, Cancer Center Karolinska, Karolinska Hospital, Stockholm, Sweden
    Nat Med 8:282-8. 2002
    The tumor suppressor p53 inhibits tumor growth primarily through its ability to induce apoptosis. Mutations in p53 occur in at least 50% of human tumors...
  73. ncbi The ubiquitin ligase COP1 is a critical negative regulator of p53
    David Dornan
    Department of Molecular Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 429:86-92. 2004
    ..2). The role of COP1 in mammalian cells is less well characterized. Here we identify the tumour-suppressor protein p53 as a COP1-interacting protein...
  74. pmc Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage
    Jonathan M Solomon
    Elixir Pharmaceuticals, Inc, One Kendall Square, Cambridge, MA 02139, USA
    Mol Cell Biol 26:28-38. 2006
    Human SIRT1 is an enzyme that deacetylates the p53 tumor suppressor protein and has been suggested to modulate p53-dependent functions including DNA damage-induced cell death...
  75. pmc Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
    Wenwei Hu
    Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA
    Proc Natl Acad Sci U S A 107:7455-60. 2010
    ..cycle arrest, apoptosis, and senescence are traditionally thought of as the major functions of the tumor suppressor p53, recent studies revealed two unique functions for this protein: p53 regulates cellular energy metabolism and ..
  76. pmc Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion
    P A J Muller
    The Beatson Institute for Cancer Research, Glasgow, UK
    Oncogene 32:1252-65. 2013
    Tumour-derived mutant p53 proteins promote invasion, in part, by enhancing Rab coupling protein (RCP)-dependent receptor recycling. Here we identified MET as an RCP-binding protein and showed that mutant p53 promoted MET recycling...
  77. ncbi The p53-Mdm2 module and the ubiquitin system
    Dan Michael
    Department of Molecular Cell Biology, Weizmann Institute of Science, PO Box 26, Rehovot 76100, Israel
    Semin Cancer Biol 13:49-58. 2003
    The p53 tumor suppressor protein is a short-lived protein, which is stabilized in response to cellular stress. The ubiquitination and degradation of p53 are largely controlled by Mdm2, an oncogenic E3 ligase...
  78. ncbi Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53
    Hiroshi Katayama
    Department of Molecular Pathology, Division of Pathology and Laboratory Medicine, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Genet 36:55-62. 2004
    ..chromosome instability and oncogenic transformation, a phenotype characteristic of loss-of-function mutations of p53. Here we show that aurora kinase A phosphorylates p53 at Ser315, leading to its ubiquitination by Mdm2 and ..
  79. pmc Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
    R Ravi
    Johns Hopkins Oncology Center, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 USA
    Genes Dev 14:34-44. 2000
    ..We demonstrate that homozygous deletion of the p53 tumor suppressor gene via homologous recombination in a human cancer cell line promotes the neovascularization and growth of ..
  80. doi Gain of function of mutant p53 by coaggregation with multiple tumor suppressors
    Jie Xu
    Switch Laboratory, Flanders Institute for Biotechnology, Vrije Universiteit Brussel, Brussels, Belgium
    Nat Chem Biol 7:285-95. 2011
    Many p53 missense mutations possess dominant-negative activity and oncogenic gain of function...
  81. ncbi p21/CDKN1A mediates negative regulation of transcription by p53
    Kristina Löhr
    Institut fur Virologie, Philipps Universitat Marburg, Robert Koch str 17, 35037 Marburg, Germany
    J Biol Chem 278:32507-16. 2003
    The tumor suppressor p53 regulates transcription positively and negatively, depending on the target gene...
  82. ncbi Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function
    D Chen
    Department of Pharmacology and Toxicology, Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Oncogene 26:5029-37. 2007
    As a major negative regulator of p53, the MDM2 oncogene plays an important role in carcinogenesis and tumor progression. MDM2 promotes p53 proteasomal degradation and negatively regulates p53 function...
  83. ncbi MDM2--master regulator of the p53 tumor suppressor protein
    J Momand
    California State University at Los Angeles, Department of Chemistry and Biochemistry, 90032, USA
    Gene 242:15-29. 2000
    MDM2 is an oncogene that mainly functions to modulate p53 tumor suppressor activity...
  84. ncbi Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases
    N A Barlev
    Molecular Genetics Program, The Wistar Institute, Philadelphia, PA 19104, USA
    Mol Cell 8:1243-54. 2001
    Cellular DNA damage causes stabilization and activation of the tumor suppressor and transcription factor p53, in part by promoting multiple covalent modifications of the p53 protein, including acetylation...
  85. pmc A germline variant in the TP53 polyadenylation signal confers cancer susceptibility
    Simon N Stacey
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 43:1098-103. 2011
    ..35, P = 1.0 × 10(-5)) and colorectal adenoma (OR = 1.39, P = 1.6 × 10(-4)). However, we observed no effect for breast cancer, a common Li-Fraumeni syndrome tumor (OR = 1.06, P = 0.57, 95% confidence interval 0.88-1.27)...
  86. pmc Regulation of p53: a collaboration between Mdm2 and Mdmx
    Dongsheng Pei
    Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou, China
    Oncotarget 3:228-35. 2012
    b>p53 plays an important role in the regulation of the cell cycle, DNA repair, and apoptosis and is an attractive cancer therapeutic target. Mdm2 and Mdmx are recognized as the main p53 negative regulators...
  87. doi A Pin1/mutant p53 axis promotes aggressiveness in breast cancer
    Javier E Girardini
    Laboratorio Nazionale CIB, Trieste, Italy
    Cancer Cell 20:79-91. 2011
    ..Here we demonstrate the fundamental role of the prolyl isomerase Pin1 in mutant p53 oncogenic functions...
  88. pmc Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53
    Saurabh Dayal
    CR UK Cell Transformation Research Group, Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland
    J Biol Chem 284:5030-41. 2009
    Both p53 and its repressor Mdm2 are subject to ubiquitination and proteasomal degradation...
  89. pmc Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a
    M Murphy
    Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Genes Dev 13:2490-501. 1999
    There is growing evidence that the p53 tumor suppressor protein not only can function to activate gene transcription but also to repress the expression of specific genes...
  90. pmc Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition
    Mu Shui Dai
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97201, USA
    Mol Cell Biol 24:7654-68. 2004
    The p53-MDM2 feedback loop is vital for cell growth control and is subjected to multiple regulations in response to various stress signals. Here we report another regulator of this loop...
  91. doi EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset
    Kentaro Inamura
    Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, Koto ku, Tokyo, Japan
    Mod Pathol 22:508-15. 2009
    ....
  92. pmc Interaction of the p53 DNA-binding domain with its n-terminal extension modulates the stability of the p53 tetramer
    Eviatar Natan
    MRC Laboratory of Molecular Biology, Cambridge, UK
    J Mol Biol 409:358-68. 2011
    The tetrameric tumor suppressor p53 plays a pivotal role in the control of the cell cycle and provides a paradigm for an emerging class of oligomeric, multidomain proteins with structured and intrinsically disordered regions...
  93. ncbi Regulation of p53 activity through lysine methylation
    Sergei Chuikov
    Howard Hughes Medical Institute, Division of Nucleic Acids Enzymology, Department of Biochemistry, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Nature 432:353-60. 2004
    b>p53 is a tumour suppressor that regulates the cellular response to genotoxic stresses. p53 is a short-lived protein and its activity is regulated mostly by stabilization via different post-translational modifications...
  94. pmc HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase
    Ataman Sendoel
    Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Nature 465:577-83. 2010
    ..germ cell apoptosis by antagonizing the function of CEP-1, the homologue of the tumour suppressor p53. The antiapoptotic property of HIF-1 is mediated by means of transcriptional upregulation of the tyrosinase family ..
  95. pmc The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
    S Y Shieh
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Genes Dev 14:289-300. 2000
    Upon DNA damage, the amino terminus of p53 is phosphorylated at a number of serine residues including S20, a site that is particularly important in regulating stability and function of the protein...
  96. pmc p53 mutations in colorectal cancer
    N R Rodrigues
    Director s Laboratory, Imperial Cancer Research Fund, Lincolns Inn Fields, London, United Kingdom
    Proc Natl Acad Sci U S A 87:7555-9. 1990
    Immunohistological staining of primary colorectal carcinomas with antibodies specific to p53 demonstrated gross overexpression of the protein in approximately 50% of the malignant tumors examined...
  97. pmc USP10 regulates p53 localization and stability by deubiquitinating p53
    Jian Yuan
    Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA
    Cell 140:384-96. 2010
    Stability and localization of p53 is essential for its tumor suppressor function. Ubiquitination by the E3 ubiquitin ligase Mdm2 is the major regulatory mechanism of p53, which induces p53 nuclear export and degradation...
  98. pmc Biological functions of p53 isoforms through evolution: lessons from animal and cellular models
    V Marcel
    Centre for Oncology and Molecular Medicine, Inserm European Associated Laboratory, University of Dundee, Ninewells Hospital, Dundee, Scotland, UK
    Cell Death Differ 18:1815-24. 2011
    ..Although first described in the eighties, the importance of p53 isoforms in regulating the suppressive functions of p53 has only become evident in the last 10 years, by analogy ..
  99. pmc DNA damage activates p53 through a phosphorylation-acetylation cascade
    K Sakaguchi
    Laboratory of Cell Biology, National Cancer Institute NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 12:2831-41. 1998
    Activation of p53-mediated transcription is a critical cellular response to DNA damage...
  100. pmc Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway
    Yanping Zhang
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 23:8902-12. 2003
    The gene encoding p53 mediates a major tumor suppression pathway that is frequently altered in human cancers. p53 function is kept at a low level during normal cell growth and is activated in response to various cellular stresses...
  101. ncbi Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cells
    Soo Jin Jeong
    Virus Tumor Biology Section, Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 5055, USA
    Oncogene 24:6719-28. 2005
    ..that AKT is activated in HTLV-1-transformed cells and that Tax activation of AKT is linked to NF-kappaB activation, p53 inhibition and cell survival...

Research Grants119 found, 100 shown here

  1. BRCA1 and progesterone receptors in breast cancer
    Eva Y Lee; Fiscal Year: 2013
    ..We have established a mouse model in which specific ablation of BRCA1 as well as p53 genes occurred in the mammary epithelial cells by WAP promoter...
  2. Chemoprevention by black raspberry in oral cancer induced by DB[a,l]P in mice
    KARAM E EL-BAYOUMY; Fiscal Year: 2013
    ..Mutations in both lacI and p53 genes in oral tissues of mice treated with DB[a,l]P are similar to those observed in OSCC in humans...
  3. Etiologic Role of HPV in Keratinocyte Carcinomas
    Margaret Karagas; Fiscal Year: 2009
    ..the presence of HPV DNA in tumor tissue and examine constitutional genetic variation in \beXRCC1, EVER1, EVER2 and p53 genes as potential modifiers of SCC susceptibility related to HPV infection...
  4. CDX2 TUMOR SUPPRESSOR PATHWAY DEFECTS IN COLON CANCER
    Eric Fearon; Fiscal Year: 2009
    ..Recent studies in CRC show that whereas the APC (adenomatous polyposis coli), KRAS, and p53 genes are each frequently altered, many other genes are each mutated in only a subset of CRCs...
  5. ALTERED PROTEOGLYCAN GENE EXPRESSION AND CANCER
    Renato V Iozzo; Fiscal Year: 2013
    ..a targeted disruption of decorin develop spontaneous colon tumors and mice with a double knock out of decorin and p53 genes die rapidly of thymic lymphomas, indicating that lack of decorin is permissive for tumorigenesis...
  6. Impact of BRG1 Loss in Lung Cancer Development
    David N Reisman; Fiscal Year: 2012
    ..However, both Rb and P53 have been functionally linked to BRG1 and BRM in vitro, suggesting that the loss of these proteins might negatively ..
  7. MECHANISMS OF P53 DEPENDENT APOPTOSIS
    H Ruley; Fiscal Year: 2000
    Experiments are described to understand mechanisms of tumor suppression by p53 and to characterize biochemical regulation of p53 and the cellular responses to p53 action...
  8. Mechanisms of Mdm2/Mdmx in repressing p53
    Wei Gu; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The p53 tumor suppressor is mutated in all kinds of human cancers...
  9. Mechanisms of Pituitary Tumorigenesis
    Shlomo Melmed; Fiscal Year: 2012
    ..E2F1 induction of Pttg transcription and protein expression in Rb mice, in mutant human cancer cells devoid of p53 or p21, as well as in human pituitary adenomas...
  10. Optimization of DNA Repair by Abh8
    Lauren Endres; Fiscal Year: 2013
    ..Indeed, defects in components of the DDR, such as ATM, BRCA1 and p53 are known to cause a predisposition to cancer development as well as hypersensitivity to ultraviolet and ionizing ..
  11. Translational Machinery in Stress Signaling and Tumor Suppression
    THOMAS J contact BEGLEY; Fiscal Year: 2010
    ..and in vivo whether specific proteins that regulate the cell cycle machinery (cyclin D1/D3, CDK4) and/or apoptosis (p53) are subject to translational regulation by TRM9...
  12. Prostate cancer chemoprevention by penta-galloyl-glucose
    Junxuan Lu; Fiscal Year: 2013
    ..PGG for chemoprevention include a rapid inhibition of DNA replicative synthesis, and an activation of the p53 tumor suppressor and inactivating the Stat3 oncogenic signaling, associated with cyclin D1 (cell cycle) and Bcl-xL/Mcl-1 (..
  13. MECHANISMS OF RADIORESISTANCE AND CELL CYCLE PROGRESSION
    Howard B Lieberman; Fiscal Year: 2013
    ..In addition, RAD9 can, like p53, act as a sequence specific transcription factor...
  14. MECHANISMS OF INTESTINAL TUMORIGENESIS
    Vincent W Yang; Fiscal Year: 2013
    ..Thus, somatic or germline inactivation of TSGs such as adenomatous polyposis coli (APC), p53 and several genes involved in DNA mismatch repair;and oncogenic activation of KRAS, BRAF and ?-catenin have been ..
  15. Functional study of C53 protein as a novel regulator of checkpoint kinases
    Honglin Li; Fiscal Year: 2012
    ..By phosphorylating downstream effectors such as p53 and Cdc25 phosphatases, Chk1/Chk2 spread damage signal and elicit either cell cycle arrest or apoptotic cell death...
  16. PROBES FOR CYTOMETRY
    Zbigniew Darzynkiewicz; Fiscal Year: 2013
    ..and multiparameter cytometry to measure phosphorylation/activation of key DDRs: histone H2AX, ATM, Chk2 and p53. The probes ability to measure DDR in response to different types of DNA damage will be assessed including that ..
  17. Mechanism of p63-Dependent Tumor Suppression
    Xinbin Chen; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: P63 is a member of the p53 tumor suppressor family and known to play a role in tumor suppression...
  18. PCAF/GCN5 ACETYLATION ON P53 TRANSACTIVATION
    Shelley L Berger; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The p53 tumor suppressor gene is frequently inactivated by mutations in human cancers...
  19. FOXO1 Inhibition in Genotoxic Stress Response and Prostate Cancer Survival
    Haojie Huang; Fiscal Year: 2013
    ..details as to how damaged cells escape to survive genotoxic stress, especially in the absence of a functional p53, are far from elucidated...
  20. Cyclin E Regulation in Normal and Neoplastic Hematopoiesis
    ALEXANDER C MINELLA; Fiscal Year: 2013
    ..We recently found that the p53 tumor suppressor is activated in erythroid progenitor cells in a DNA damage-type response to impaired Fbw7-mediated cyclin E ..
  21. Hepatitis C and Tumor Suppressors in Hepatocellular
    Stanley M Lemon; Fiscal Year: 2011
    ..Our hypothesis is that these and other interactions with host proteins (p53 and DDX5) promote proliferation of hepatocytes and impair DNA damage responses, tljiereby contributing to HCV ..
  22. HYPOXIA AND GENE REPRESSION
    Amato J Giaccia; Fiscal Year: 2013
    ..The tumor suppressor protein p53 induces rapid apoptosis in response to oxygen concentrations that induce an S-phase arrest...
  23. The MRAD9 Radioresistance Gene
    Howard B Lieberman; Fiscal Year: 2013
    ..We also found that this multifunctional Rad9 protein can bind p53 and co- regulate p21. Recent studies indicate that Rad9 also participates in multiple DNA repair pathways as well...
  24. Targeted Degradation of DNA Damage Response Proteins by Autophagy
    Thomas J Begley; Fiscal Year: 2013
    ..Additionally, mTOR inhibition and the induction of autophagy have been linked to p53 and Ataxia-telangiectasia mutated (ATM) signaling after DNA damage...
  25. Cell cycle checkpoint defects lead to chronic inflammation in RA
    Thomas M Aune; Fiscal Year: 2013
    ..or other intrinsic pathways, these repair mechanisms;ATR, DNA-PKcs, and ATM, and cell cycle checkpoints, JNK2, p53, p21, p27, CHEK2, RANGAP1 are defective resulting in failure of DNA repair and loss of genomic integrity...
  26. Mechanism of p73-dependent tumor suppression
    Xinbin Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The p73 gene, a member of the p53 family, is controlled by two alternate promoters. When the upstream P1 promoter is used for p73 expression, several TAp73 isoforms are produced...
  27. Chemical Modulators for p53 Functions in Transcriptional Regulation
    SYED S MUJTABA; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The most essential human tumor suppressor protein p53 is mutated in more than 50% of the human cancers...
  28. The Identification and characterization of the methylation of Retinablastoma
    Louis A Saddic; Fiscal Year: 2010
    ..Based on previous observations regarding how methylation affects the function of p53, another cell cycle and cell death regulator, we will use a combination of biochemical, molecular, and cellular ..
  29. Rapamycin-induced Selective Apoptosis in Malignant Cells
    Peter J Houghton; Fiscal Year: 2012
    ..mTORC1 by rapamycin induced a prolonged stress response that resulted in apoptosis only in cells lacking functional p53. Thus, potentially identifying a synthetic lethal interaction between mTORC1 and p53 that could be exploited ..
  30. The role of DEK in breast cancer development and therapy
    LISA MARIE PRIVETTE VINNEDGE; Fiscal Year: 2010
    ..and apoptosis in primary keratinocytes and in cervical cancer cells, presumably through regulation of the p53 protein family. However, its oncogenic activities in vivo remain poorly understood...
  31. Regulation and Function of C/EBP in UVB Responses
    Robert C Smart; Fiscal Year: 2010
    ..agents, are potent inducers of C/EBPa expression in human and mouse keratinocytes and that this induction requires p53, Thus, we have identified C/EBPa as a novel p53-regulated DNA damage-inducible gene in human and mouse ..
  32. Development of cambinol analogues as antilymphoma agents
    Antonio Bedalov; Fiscal Year: 2012
    ..cellular responses to stress and in tumorigenesis through deacetylation of important regulatory proteins including p53 and the BCL6 oncoprotein...
  33. Regultion of p53 Deubiquitination
    Zhenkun Lou; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): p53 is an important tumor suppressor that is mutated in more than 50% of human cancers...
  34. Molecular Mechanism of Mule in DNA Damage Response and Tumorigenesis
    Qing Zhong; Fiscal Year: 2013
    ..Besides Mcl-1, Mule also ubiquitinates other substrates including p53, thus adding another intriguing link to the apoptosis pathway...
  35. Genome wide analysis of p53 inhibition by high glucose
    Selene Bobadilla; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The tumor suppressor p53 plays a prominent role in cancer and much of human biology...
  36. A Novel Human DNA Damage Response Which Directly Alters DNA Polymerase Delta
    CHRISTINE ELIZABETH LEROY; Fiscal Year: 2013
    ..In addition, cell lines which are deficient in specific DNA damage response proteins (such as p53 or ATM) will be utilized, such that the signaling processes which lead to p12 degradation can be more ..
  37. Dual Targeting of DNA Repair and p53 pathways for treatment of brain cancer
    KAREN ELIZABETH POLLOK; Fiscal Year: 2013
    ..remains poor, and is largely due to the ability of these malignancies to acquire chemoresistance by modulation of p53-regulated signaling pathways that control cell survival...
  38. The Role of JAB1 in osteosarcoma pathogenesis
    Guang Zhou; Fiscal Year: 2013
    ..JAB1 expression is inversely correlated with the expression of tumor suppressor p27 and p53 in some metastases...
  39. Role of p53-mediated unconventional functions in tumor suppression
    Wei Gu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): There is accumulating evidence indicating that p53 is critical in regulation of glycolysis, reactive oxygen species (ROS) production and oxidative stress responses under normal physiological ..
  40. Therapeutic Targeting of Oncogenic Stress in Cancer Treatment
    Weei Chin Lin; Fiscal Year: 2013
    ..Oncogenic stress can lead to activation of p53, which induces either apoptosis or cellular senescence and serves as an important barrier to tumorigenesis...
  41. Chk1 signaling in the G2 DNA damage checkpoint
    MATTHEW O CONNELL; Fiscal Year: 2009
    ..Whilst loss of p53-dependent checkpoints are common in tumors, Chk1 loss is not seen and suggests that Chk1 is essential for tumor ..
  42. Cellular Stress Response Signaling Pathways
    MICHAEL BARRY KASTAN; Fiscal Year: 2013
    ..The induction of p53 protein after DNA damage and other stresses is a critical determinant of cellular outcome after exposure to many ..
  43. Transcriptional regulation of apoptosis
    James J Manfredi; Fiscal Year: 2013
    Resistance to apoptosis contributes to tumorigenesis as well as poor therapeutic outcome. The tumor suppressor p53 mediates two predominant cellular responses, cell cycle arrest and apoptosis, but the molecular basis for this cell fate ..
  44. Defining novel pathways that arrest genetically unstable tetraploid cells
    Neil J Ganem; Fiscal Year: 2013
    ..Consequently, cells possess p53-dependent tumor suppression mechanisms that limit the further proliferation of these cells by promoting a durable ..
  45. Alcohol and PAH-induced carcinogenesis
    Jagat J Mukherjee; Fiscal Year: 2013
    ..Previously we observed accumulation of p53 tumor suppressor protein and G1->S cell cycle arrest as well as cell transformation in response to BPDE treatment of JB6 ..
  46. Curcumin inhbits BPDE-induced damage by lowering the threshold of p53 activation
    ERICA NICOLE ROGERS; Fiscal Year: 2011
    ..of this project is to elucidate whether pretreatment with curcumin inhibits BPDE-induced DMA damage by activating p53. We hypothesize that curcumin may reduce the mutagenic activity of low dose BPDE by lowering the threshold of p53 ..
  47. Mechanism of p53-dependent tumor suppression
    Xinbin Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mechanism of p53-dependent tumor suppression Summary P53 tumor suppressor is activated in response to stress signals, including DNA damage and hypoxia...
  48. Defining novel pathways that arrest genetically unstable tetraploid cells
    Neil J Ganem; Fiscal Year: 2012
    ..Consequently, cells possess p53-dependent tumor suppression mechanisms that limit the further proliferation of these cells by promoting a durable ..
  49. PATHOGENESIS OF HEPATOCELLULAR CARCINOMA
    Nelson Fausto; Fiscal Year: 2010
    ..A striking feature of tumorigenesis in Ku70-/- mice is the almost complete lack of p53 protein expression without alteration in p53 mRNA levels...
  50. Bid regulation of cutaneous photodamage responses
    Laura Timares; Fiscal Year: 2010
    ..The dual functions of Bid have some similarities to the tumor suppressor p53, the best-known regulator of cell fate...
  51. MITOCHONDRIAL MOTILITY AND INHERITANCE
    Liza A Pon; Fiscal Year: 2013
    ..Since mutation of Chk2 and its upstream (ATM) and downstream (p53) regulators also results in changes in mtDNA content and cell cycle delays in mammalian and human cells, this ..
  52. Genomic stability of human pluripotent stem cells
    PAUL HUBERT LEROU; Fiscal Year: 2010
    ..ES cells maintain genomic stability even though they have altered Rb and p53 function and they are able to escape senescence, dividing indefinitely without the accruing DNA damage...
  53. Structural Biology of Lysine Methylation in DNA Damage and Checkpoint Signaling
    Georges Mer; Fiscal Year: 2012
    ..We will probe several molecular interactions driven by the methylation of histone H4 at lysine 20 (H4-K20) and p53 at lysine 370 (p53-K370), and their possible synergistic coupling to other post-translational modifications (e.g...
  54. Mechanisms for Selective Transcription of p53 Targets by the AcK120 Isoform
    Jessica Monteith; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The p53 tumor suppressor pathway is inactivated in most forms of human cancer. In normal cells, p53 is maintained at low levels by ubiquitylation and subsequent proteosome-mediated degradation...
  55. Regulation of the ATM/ATR-p53 DNA Damage Signaling Pathway by the Wip1 Phosphatas
    Xiongbin Lu; Fiscal Year: 2013
    ..aberrantly regulated, Wip1 becomes an oncogenic phosphatase that inhibits ATM/ATR DNA damage response and p53 tumor suppressor pathways...
  56. Role of p53 in cell cycle checkpoints
    James J Manfredi; Fiscal Year: 2013
    b>p53 has clearly been implicated as a tumor suppressor in human cancer with mutation of the p53 gene being a common event. p53 has a well-characterized role in mediating the cellular response to DNA damage...
  57. Re-replication of chromosomes and cancer
    Anindya Dutta; Fiscal Year: 2013
    ..checkpoint pathways used several genes whose mutations predispose individuals to genomic instability and cancer: p53, BrCa1 and the Fanconi Anemia proteins...
  58. Epigenetic Regulation by Large Non-Coding RNAs in the p53 Mediated DNA Damage Res
    JOHN LOUIS RINN; Fiscal Year: 2013
    ..For example, we discovered that p53 directly regulates a lincRNA that is required for proper localization of chromatin factors to mediate p53 dependent ..
  59. The Study of the Circadian Rhythm in p53 Signaling
    LONING NONE FU; Fiscal Year: 2013
    ..We have reported previously that the expression of c-myc and p53 follows a circadian rhythm in vivo and loss of function in the circadian genes, Period1 and 2, leads to neoplastic ..
  60. Protein Kinase Signaling and Cell Cycle Control
    Michael B Yaffe; Fiscal Year: 2013
    ..a third DNA damage response pathway mediated by p38MAPK and MAPKAP Kinase-2 (MK2) that is absolutely essential for p53-defective tumor cells to survive after DNA damage...
  61. Regulation of Ionizing Radiation Induced DNA Damage Response
    Xiaochun Yu; Fiscal Year: 2013
    ..RNF8-dependent H2AX ubiquitination may regulate downstream 53BP1 (p53 Binding Protein 1) and BRCA1 (Breast Cancer Susceptibility Gene 1) translocation to DNA damage sites...
  62. Genomic stability of human pluripotent stem cells
    PAUL HUBERT LEROU; Fiscal Year: 2013
    ..ES cells maintain genomic stability even though they have altered Rb and p53 function and they are able to escape senescence, dividing indefinitely without the accruing DNA damage...
  63. CHARACTERIZATION OF NEW HUMAN P53 DISSOCIATORS
    Rainer Brachmann; Fiscal Year: 2004
    The human tumor suppressor protein and transcription factor p53 integrates stress signals, such as DNA damage, hypoxia and ribonucleotide depletion, and induces either cell cycle arrest or apoptosis...
  64. Lipid peroxidation product induced DNA damage in the p53 gene and liver cancer
    ERIC MOON SHONG M TANG; Fiscal Year: 2010
    ..By mapping the 4-HNE-DNA adduct distribution at the sequence level in human p53 gene fragments and genomic DNA we have found that 4-HNE preferentially binds to -GAGGC/A- sequences, including ..
  65. Functional Analysis of p53 Polymorphic Variants
    Maureen E Murphy; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The central importance of the p53 tumor suppressor gene to human cancer research is best epitomized by the following facts: 1) p53 is the most frequently mutated gene in human cancer;2) p53 is a ..
  66. Resolution of Epithelial Cell Hyperplasia
    Yohannes Tesfaigzi; Fiscal Year: 2013
    ..A polymorphism in the p53 gene at codon 72 (Arg/Pro) differentially affects Bcl-2 expression;p53Pro increases more efficiently than p53Arg, ..
  67. Epigenetic Changes Link COPD and Lung Cancer
    Yohannes Tesfaigzi; Fiscal Year: 2013
    ..within this pathway as determinants for gene methylation in sputum and that the proline variant at codon 72 of p53 is protective from mucous cell hyperplasia and decline of pulmonary function in the LSC...
  68. Role of ribosome impairments in X-linked Dyskeratosis Congenita pathogenesis
    Davide Ruggero; Fiscal Year: 2013
    ..translational screen and uncovered the first functional targets of X-DC that include important mRNAs such as p53 and p27...
  69. Molecular Epidemiology of DNA Repair in Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2012
    ..proposed association study is highly hypothesis-driven, expanding our preliminary data on the findings of a novel p53-PHB-PIG3 apoptosis mechanism...
  70. Genotypes and Phenotypes of Apoptosis and Risk of Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2013
    ..proposed association study is highly hypothesis driven, expanding our preliminary data on the findings of a novel p53-PHB-PIG3 apoptosis mechanism...
  71. Murine Model of HCV-Associated Human Liver Cancer
    Lishan Su; Fiscal Year: 2013
    ..In Aim 2, p53 will be inactivated in human hepatoblasts prior to transplantation into AFC8 mice to provide for accelerated ..
  72. Role of PALB2 in the DNA damage response and breast cancer suppression
    Bing Xia; Fiscal Year: 2013
    ..will be asked: 1) Does PALB2 inactivation in breast epithelial cells lead to mammary tumor formation? 2) Does p53 play a role in PALB2-mediated tumor suppression, given that p53 and BRCA2 function synergistically to suppress ..
  73. Allergies, Genetic Susceptibility and Adult Glioma Risk
    Dominique S Michaud; Fiscal Year: 2011
    ..Improving our understanding of the etiology of gliomas will provide opportunities for treatment options or prevention of this deadly cancer. ..
  74. Development of a Urine Test for the Early Detection of Liver Cancer
    Wei Song; Fiscal Year: 2012
    ..We propose a new diagnostic method, based on our progress in detecting the HCC-specific p53 mutation in the urine of patients with HCC that will enable detection of small fractions of HCC-derived genetic and ..
  75. Role of p53 polymorphisms in disparities in breast carcinogenesis and outcome .
    ROBIN S FUCHS-YOUNG; Fiscal Year: 2013
    ..We hypothesize that racially disproportionate p53 variants with reduced or altered function contribute to breast cancer health disparities and lack of pregnancy ..
  76. Non-invasive sampling of DNA markers for pancreatic cancer screening
    Yu Tsueng Liu; Fiscal Year: 2013
    ..and the particles to normal mice, test the recovery of KRAS mutations in stool;(2b) Using triple knockout (KRAS-cre-p53) pancreatic cancer model (KPC), test the increase in sensitivity of detection of KRAS mutation in stool...
  77. Retention of somatic mutations in cancers by changes in pH sensing
    RYAN DANIEL HERNANDEZ; Fiscal Year: 2013
    ..To our knowledge mutations in cancers conferring pH sensing, such as p53-R273H, one of the most commonly occurring mutations we will test, has not been reported, nor has the retention of ..
  78. Genetic Susceptibility to Nanoparticle-Induced Respiratory Disease
    JAMES CHRISTOPHER BONNER; Fiscal Year: 2013
    ..and mesothelioma is due to reduced expression or impaired functional interaction between COX-2, STAT-1, and p53. The following specific aims will be carried out to test this hypothesis: In Aim 1, we will determine whether COX-2 ..
  79. Regulation of Human Papillomavirus Replication via Cell Signaling Pathways
    ANASTACIA GRIEGO; Fiscal Year: 2013
    ..in EGFR-pathway signaling will result in down regulation of HPV activities in infected cells, leading to recovered p53 and pRb activity, which could render cells more susceptible to chemotherapy and radiation...
  80. Regulations of DNA Alkylation/Deamination Damage Repair
    Rabindra Roy; Fiscal Year: 2013
    ..and repair efficiency depending on sequence context including mutation hotspot sequences in tumor suppressor gene, p53;(2) elucidate the mechanism of recognition of base lesions in MPG-specific BER pathway by analyzing the effect of ..
  81. Role of vitamin D receptor in DNA repair
    Dennis H Oh; Fiscal Year: 2013
    ..The dependence of UV-induced VDR expression on the p53 family and on biologically active vitamin D will be measured...
  82. Genome maintenance functions of CREB/ATF transcription factors
    RANDAL SCOT TIBBETTS; Fiscal Year: 2013
    ..A key aspect of these studies is to test whether the ATM-CREB pathway synergizes with a parallel ATM-p53 pathway to mediate tumor suppression in vivo...
  83. Novel small-molecule inhibitors of Wee1 kinase for medulloblastoma treatment
    Philip Reigan; Fiscal Year: 2013
    ..In addition, we will determine if p53 playsa role in mediating sensitivity to Wee1 inhibition in medulloblastoma and if Wee1 inhibition has therapeutic ..
  84. Characterization of persistent hyperemic foci and their role in photocarcinogenes
    Raymond L Konger; Fiscal Year: 2013
    ..whether the epidermis overlying early hyperemic areas exhibit increased mutations of the key DNA damage regulator, p53, which is known to augment the SASP response...
  85. Epigenetic Regulation of Cell and Tissue Aging
    Nikolai A Timchenko; Fiscal Year: 2013
    ..The RB/p16INK4a, but not p53, pathway regulates the senescence of human melanocytes in culture and melanocytic nevi in vivo...
  86. Biologic and therapeutic relevance of DNMT3A mutations in acute myeloid leukemia
    Olga A Guryanova; Fiscal Year: 2013
    ..Our mechanistic studies point at impaired DNA damage response including attenuation of p53 activation...
  87. Skin Cancer Chemoprevention by Silibinin: Mechanisms and Efficacy
    Rajesh Agarwal; Fiscal Year: 2013
    ..These initiated cells harbor mutations primarily in p53 tumor suppressor gene that eventually lead to their clonal expansion and formation of skin tumors...
  88. The role of p53 redox-modification in cell fate signaling
    Jason M Held; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The tumor suppressor p53 is a central hub in multiple cancer-related signaling networks that control cell proliferation and cell fate decisions...
  89. Characterization and regulation of the MED17-p53 binding interface.
    Zachary C Poss; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The p53 protein is a transcription factor and tumor suppressor that is frequently mutated in human cancers...
  90. Roles of p63 in regulation of miRNA and LincRNA targets in metastatic cancer
    Elsa R Flores; Fiscal Year: 2013
    ..The functions of p63, a p53 family member, are beginning to be understood in contexts in which p53 function has been well established, ..
  91. STATUS OF P53 IN A LFS CANCER PRONE FAMILY
    Esther Chang; Fiscal Year: 1999
    ..The tumor suppressor gene p53 has been shown to frequently altered in a wide variety of sporatic tumors...
  92. Regulation of p53 by BRCA1 in Breast Cancer
    JOY CHIEH YU LIN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The overall frequency of p53 mutation in breast cancer is much lower compared to other cancers despite a high risk of breast cancer associated with p53 germ-line mutations...
  93. Nuclear Accumulation of Cyclin D1 and Oncogenesis
    JOHN ALAN DIEHL; Fiscal Year: 2013
    ..to human MCL, is genomically unstable and exhibits a paradox associated with human disease;retention of wild type p53. Because p53 functions to limit expansion of genomically unstable cells, MCL must bypass p53 without selection for ..
  94. Mechanisms of DNA damage-induced, p53-dependent repression of the Cdc25C Phosphat
    Luis A Carvajal; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The tumor suppressor p53 is the most commonly mutated gene found in human cancers [3]. It plays a vital role in guarding mammalian cells against tumorigenesis [22,23]...
  95. Gain of function mutant p53 in telomere uncapping-driven breast tumorigenesis
    Yibin Deng; Fiscal Year: 2013
    ..the other hand, recent systematic genomic analyses in human breast carcinomas have revealed that tumor suppressor p53 is the most commonly alerted gene, predominantly through missense mutations that result in accumulation of mutant ..
  96. The Role of ATF3 in the DNA Damage Response
    Chunhong Yan; Fiscal Year: 2013
    ..We therefore hypothesize that these interactions could be behind the mechanisms by which ATF3 regulates p53 tumor suppressor activity in the DNA damage response...
  97. Selective Sensitization of Pancreatic Cancer to Therapy by Chk1 and PARP1 Inhibit
    Meredith A Morgan; Fiscal Year: 2013
    ..Importantly, Chk1 inhibition preferentially sensitizes p53-mutant tumor cells and K-Ras mutation may also confer sensitivity to Chk1 inhibition...
  98. Regulation of Mdmx stability and subcellular localization by ubiquitination
    Wei Gu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The p53 tumor suppressor acts as the major sensor for a regulatory circuit that monitors signaling pathways from diverse sources, including DNA damage, oncogenic events, ribosomal stress and others ..
  99. REGULATION OF SKELETAL MUSCLE METABOLISM
    Leonard S Jefferson; Fiscal Year: 2013
    ..perform a detailed analysis of components of the mTORC1 signaling pathway, including novel upstream inputs such as p53 and Sestrin 1, 2, and 3, as well as selected novel regulatory mechanisms that mediate control of protein synthesis, ..
  100. Spindle Assembly Checkpoint, Chromosome Stability, and Cancer
    Pumin Zhang; Fiscal Year: 2013
    ..scale, one must ask: do cells mount a response to it? Our previous work demonstrated that aneuploidy could activate p53 and cause apoptotic cell death...
  101. The SMC5/6 Complex - DNA Damage Response Regulation Ensures Meiotic Fidelity
    Philip W Jordan; Fiscal Year: 2013
    ..The BAT3-EP300 complex is required for the activation of a TRP53-mediated DNA damage response...