p38

Summary

Gene Symbol: p38
Description: mitogen-activated protein kinase 14
Alias: CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, SAPK2A, p38, p38ALPHA, CSAID-binding protein, Csaids binding protein, MAP kinase 14, MAP kinase Mxi2, MAP kinase p38 alpha, MAX-interacting protein 2, cytokine suppressive anti-inflammatory drug binding protein, cytokine suppressive anti-inflammatory drug-binding protein, mitogen-activated protein kinase p38 alpha, p38 MAP kinase, p38 mitogen activated protein kinase, p38alpha Exip, stress-activated protein kinase 2A
Species: human

Top Publications

  1. ncbi A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
    J Han
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    Science 265:808-11. 1994
  2. ncbi Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
    M Deak
    MRC Protein Phosphorylation Unit, Departments of Biochemistry, Anatomy and Physiology, University of Dundee, Scotland
    EMBO J 17:4426-41. 1998
  3. ncbi Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals
    Y Wu
    Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, People s Republic of China
    Oncogene 25:5787-800. 2006
  4. ncbi p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint
    Vanesa Lafarga
    CNIO Spanish National Cancer Center, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Mol Cell Biol 29:4341-51. 2009
  5. ncbi Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3
    Sofia Edlund
    Ludwig Institute for Cancer Research, Biomedical Centre, 75124 Uppsala, Sweden
    Mol Biol Cell 14:529-44. 2003
  6. ncbi IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation
    Dolores M Cortez
    Department of Veterans Affairs South Texas Veterans Health Care System, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Am J Physiol Heart Circ Physiol 293:H3356-65. 2007
  7. ncbi Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1
    P Puigserver
    Dana Farber Cancer Institute, Department of Cell Biology, Boston, MA 02115, USA
    Mol Cell 8:971-82. 2001
  8. ncbi Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: role of mitogen-activated protein kinases and Nrf2
    Anila A Anwar
    Cardiovascular Division, GKT Schools of Biomedical Sciences and Medicine, King s College, University of London, Guy s Hospital Campus, London SE1 1UL, UK
    Free Radic Biol Med 39:227-36. 2005
  9. ncbi p38alpha and p38delta mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells
    M R Junttila
    Deparment of Dermatology, University of Turku, Turku, Finland
    Oncogene 26:5267-79. 2007
  10. ncbi p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
    Juan Jose Ventura
    CNIO Spanish National Cancer Center, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Nat Genet 39:750-8. 2007

Research Grants

  1. Regulation of airway epithelial repair
    Steven R White; Fiscal Year: 2010
  2. Regulation of airway epithelial repair
    Steven White; Fiscal Year: 2006
  3. Regulation of airway epithelial repair
    Steven White; Fiscal Year: 2007
  4. Role of Signal Transduction in Burn and Wound Healing
    Saman Arbabi; Fiscal Year: 2006
  5. Reactive Oxygen Species in Coronary Collateral Growth
    William M Chilian; Fiscal Year: 2010
  6. Reactive Oxygen Species in Coronary Collateral Growth
    WILLIAM CHILIAN; Fiscal Year: 2009
  7. Transcription & Function of Adipocyte Beta3AR in Obesity
    Sheila Collins; Fiscal Year: 2006
  8. p38 MAP kinase in early thymocyte development
    Mercedes Rincon; Fiscal Year: 2009
  9. p38 MAP kinase in early thymocyte development
    Mercedes Rincon; Fiscal Year: 2010
  10. P38 MAP KINASE SIGNALING IN SKIN
    Tatiana Efimova; Fiscal Year: 2010

Detail Information

Publications231 found, 100 shown here

  1. ncbi A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
    J Han
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    Science 265:808-11. 1994
    ..A protein kinase, p38, that was tyrosine phosphorylated in response to LPS, was cloned...
  2. ncbi Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
    M Deak
    MRC Protein Phosphorylation Unit, Departments of Biochemistry, Anatomy and Physiology, University of Dundee, Scotland
    EMBO J 17:4426-41. 1998
    ..MSK1 is activated in vitro by MAPK2/ERK2 or SAPK2/p38. Endogenous MSK1 is activated in 293 cells by either growth factor/phorbol ester stimulation, or by exposure to UV ..
  3. ncbi Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals
    Y Wu
    Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, People s Republic of China
    Oncogene 25:5787-800. 2006
    ..Overexpression of GSTP1-1 inhibited TRAF2-induced activation of both JNK and p38 but not of nuclear factor-kappaB (NF-kappaB)...
  4. ncbi p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint
    Vanesa Lafarga
    CNIO Spanish National Cancer Center, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Mol Cell Biol 29:4341-51. 2009
    Activation of p38 mitogen-activated protein kinase (MAPK) plays an important role in the G(2)/M cell cycle arrest induced by DNA damage, but little is known about the role of this signaling pathway in the G(1)/S transition...
  5. ncbi Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3
    Sofia Edlund
    Ludwig Institute for Cancer Research, Biomedical Centre, 75124 Uppsala, Sweden
    Mol Biol Cell 14:529-44. 2003
    ..prostate cancer PC-3U cells induced by TGF-beta1 or Smad7 overexpression is caused by a specific activation of the p38 mitogen-activated protein kinase pathway in a TGF-beta-activated kinase 1 (TAK1)- and mitogen-activated protein ..
  6. ncbi IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation
    Dolores M Cortez
    Department of Veterans Affairs South Texas Veterans Health Care System, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Am J Physiol Heart Circ Physiol 293:H3356-65. 2007
    ..and ELISA; transcriptional induction and transcription factor binding by EMSA, ELISA, and reporter assay; and p38 MAPK and ERK1/2 activation by protein kinase assays and Western blotting...
  7. ncbi Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1
    P Puigserver
    Dana Farber Cancer Institute, Department of Cell Biology, Boston, MA 02115, USA
    Mol Cell 8:971-82. 2001
    ..These data illustrate a direct thermogenic action of cytokines and p38 MAP kinase through the transcriptional coactivator PGC-1.
  8. ncbi Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: role of mitogen-activated protein kinases and Nrf2
    Anila A Anwar
    Cardiovascular Division, GKT Schools of Biomedical Sciences and Medicine, King s College, University of London, Guy s Hospital Campus, London SE1 1UL, UK
    Free Radic Biol Med 39:227-36. 2005
    ..Inhibitors of protein kinase C (PKC) or mitogen-activated protein kinases (MAPK) p38(MAPK) and MEK or c-jun-NH2-terminal kinase (JNK) significantly attenuated induction of HO-1...
  9. ncbi p38alpha and p38delta mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells
    M R Junttila
    Deparment of Dermatology, University of Turku, Turku, Finland
    Oncogene 26:5267-79. 2007
    ..of p38 pathway component mRNA expression in HNSCC cell lines (n=42) compared to HEKs (n=8) revealed that p38alpha and p38delta isoforms are predominantly expressed in both cell types and that MKK3 is the primary upstream ..
  10. ncbi p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
    Juan Jose Ventura
    CNIO Spanish National Cancer Center, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Nat Genet 39:750-8. 2007
    Stem cell function is central for the maintenance of normal tissue homeostasis. Here we show that deletion of p38alpha mitogen-activated protein (MAP) kinase in adult mice results in increased proliferation and defective differentiation ..
  11. ncbi Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta-induced IL-8 expression in human vascular smooth muscle cells
    Young D Jung
    Chonnam National University Research Institute of Medical Sciences, Hakdong 5, Kwangju, Korea
    Cytokine 18:206-13. 2002
    ..b>P38 mitogen-activated protein kinase (MAPK) was activated after 5min of IL-1beta treatment, whereas the extracellular ..
  12. ncbi Mitogen-activated protein kinases regulate LSF occupancy at the human immunodeficiency virus type 1 promoter
    Loyda Ylisastigui
    University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Y9 206a, Dallas, TX 75390 9113, USA
    J Virol 79:5952-62. 2005
    ..In vitro, phosphorylation of LSF by Erk decreases binding to the LTR, while binding is increased by p38 phosphorylation...
  13. ncbi Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphatase
    Robin J Dickinson
    Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital, Dundee DD1 9SY, Scotland, U K
    Biochem J 364:145-55. 2002
    ..extracellular signal-regulated kinases (ERKs) 1 and 2 and, to a lesser extent, the stress-activated MAPK p38alpha. These properties define the ability of this enzyme to dephosphorylate and inactivate ERK1/2 and p38alpha, but ..
  14. ncbi p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression
    J Westermarck
    Turku Centre for Biotechnology, University of Turku, University of Turku, FIN 20520 Turku, Finland
    Mol Cell Biol 21:2373-83. 2001
    ..Specific activation of p38alpha by adenovirus-delivered constitutively active MKK3b resulted in potent inhibition of the activity of ERK1,2 and ..
  15. ncbi HIV type 1 glycoprotein 120 inhibits human B cell chemotaxis to CXC chemokine ligand (CXCL) 12, CC chemokine ligand (CCL)20, and CCL21
    Gamal Badr
    Institut National de la Sante et de la Recherche Medicale, Unité 131, Institut Paris Sud sur les Cytokines, Clamart, France
    J Immunol 175:302-10. 2005
    ..Unlike CXCL12, gp120 did not induce the activation of phospholipase Cbeta3 and PI3K downstream from CXCR4, whereas p38 MAPK activation was observed...
  16. ncbi DJ-1 modulates the p38 mitogen-activated protein kinase pathway through physical interaction with apoptosis signal-regulating kinase 1
    Jung Soon Mo
    Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Yongbong Dong, Buk Ku, Gwangju 500 757, Republic of Korea
    J Cell Biochem 110:229-37. 2010
    ..of DJ-1 inhibited H(2)O(2)-induced activation of ASK1 as well as the activation of downstream kinases in the p38 mitogen-activated protein kinase (MAPK) signaling cascade...
  17. ncbi Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis
    Mustafa Zakkar
    British Heart Foundation Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Circ Res 103:726-32. 2008
    ..induce adhesion molecules (eg, vascular cell adhesion molecule [VCAM]-1) in endothelial cells (ECs) by activating p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein (MAP) kinases by phosphorylation...
  18. ncbi Suppression of p38 MAPK and JNK via Akt-mediated inhibition of apoptosis signal-regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose-dependent insulinotropic polypeptide
    Scott B Widenmaier
    Department of Cellular and Physiological Sciences and the Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 284:30372-82. 2009
    ..Akt, and Akt siRNA, it was demonstrated that GIP promoted beta-cell survival via Akt-dependent suppression of p38 MAPK and JNK and that combined inhibition was sufficient to explain the entire pro-survival responses to GIP during ..
  19. ncbi Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt
    David Romano
    Proteomics and Signalling Networks Group, The Beatson Institute for Cancer Research, London, United Kingdom
    Cancer Res 70:1195-203. 2010
    ..kinase but enhanced binding to tumor suppressor RASSF1A, accentuating downstream c-Jun NH(2)-terminal kinase and p38 mitogen-activated protein kinase signaling and promoting apoptosis...
  20. ncbi Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
    D V Bulavin
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 18:6845-54. 1999
    Components of the ras signaling pathway contribute to activation of cellular p53. In MCF-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway...
  21. ncbi HIV-1 glycoprotein 120 induces the MMP-9 cytopathogenic factor production that is abolished by inhibition of the p38 mitogen-activated protein kinase signaling pathway
    D Missé
    Laboratoire d Immunologie Rétrovirale et Moléculaire, the Institut de Recherche pour le Développement and the Centre National de la Recherche Scientifique, 240 Av E Jeanbrau, 34094 Montpellier, France
    Blood 98:541-7. 2001
    ..Thus, both p38 and SAPK/Jun N-terminal kinase mitogen-activated protein kinases (MAPKs) are activated on stimulation of these ..
  22. ncbi Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope
    Jean Luc Perfettini
    Centre National Recherche Scientifique UMR8125, Institut Gustave Roussy, F 94805 Villejuif, France
    J Exp Med 201:279-89. 2005
    ..Cytoplasmic p38 mitogen-activated protein kinase (MAPK) was found to undergo an activating phosphorylation (p38T180/Y182P [p38 with ..
  23. ncbi Human immunodeficiency virus type 1 Nef induces programmed death 1 expression through a p38 mitogen-activated protein kinase-dependent mechanism
    Karuppiah Muthumani
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Virol 82:11536-44. 2008
    ..Nef-induced PD-1 upregulation requires its proline-rich motif and the activation of the downstream kinase p38. Further, inhibition of Nef activity by p38 MAPK inhibitor effectively blocked PD-1 upregulation, suggesting that ..
  24. ncbi p38 MAPK in development and cancer
    Cynthia Bradham
    DCMB Group, Duke University, Durham, North Carolina, USA
    Cell Cycle 5:824-8. 2006
    b>p38 is a MAPK that has been shown to induce a wide variety of biological effects in cell culture in response to a wide range of stimuli...
  25. ncbi Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK
    Kazuyuki Kitatani
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 281:36793-802. 2006
    ..PMA treatment resulted in transient activation of mitogen-activated protein kinases (ERK1/2, JNK1/2, and p38) followed by dephosphorylation/inactivation...
  26. ncbi Role of p38 MAPK and RNA-dependent protein kinase (PKR) in hepatitis C virus core-dependent nuclear delocalization of cyclin B1
    Alessandra Spaziani
    Laboratory of Clinical Hepatology, Department of Internal Medicine, University of L Aquila, 67100 L Aquila, Italy
    J Biol Chem 281:10983-9. 2006
    ..On the other hand, the viral protein also increases the activity of the cyclin B1-CDK1 complex via the p38 MAPK and JNK pathways...
  27. ncbi MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
    J Raingeaud
    Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01605 USA
    Mol Cell Biol 16:1247-55. 1996
    ..The detection of p38 MAP kinase in the nucleus of activated cells suggests that p38 MAP kinase can mediate signaling to the nucleus...
  28. ncbi Crystal structure of p38 mitogen-activated protein kinase
    K P Wilson
    Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts 02139 4211, USA
    J Biol Chem 271:27696-700. 1996
    b>p38 mitogen-activated protein kinase is activated by environmental stress and cytokines and plays a role in transcriptional regulation and inflammatory responses...
  29. ncbi Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest
    K Takenaka
    Department of Biophysics, Graduate School of Science, Kyoto University, Kitashirakawa Oiwake, Sakyo ku, Kyoto 606 01, Japan
    Science 280:599-602. 1998
    ..classical MAPK (also called ERK), c-Jun amino-terminal or stress-activated protein kinase (JNK or SAPK), and p38. Although MAPK is essential for meiotic processes in Xenopus oocytes and the spindle assembly checkpoint in Xenopus ..
  30. ncbi REX-1 expression and p38 MAPK activation status can determine proliferation/differentiation fates in human mesenchymal stem cells
    Dilli Ram Bhandari
    Adult Stem Cell Research, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea
    PLoS ONE 5:e10493. 2010
    ..Human mesenchymal stem cells (hMSCs) isolated from young tissues and cancer cells express REX1...
  31. ncbi HIV-1 Tat protein induces IL-10 production by an alternative TNF-alpha-independent pathway in monocytes: role of PKC-delta and p38 MAP kinase
    Kaoutar Leghmari
    Laboratoire d Immuno Virologie, EA 3038, Université Paul Sabatier 118, route de Narbonne 4R3, 31062 Toulouse, Cedex, France
    Cell Immunol 253:45-53. 2008
    ..induce IL-10 production, we evaluated the link between Tat, TNF-alpha and IL-10 and the implication of PKC and p38 MAP kinase pathways...
  32. ncbi The mitogen-activated protein kinase p38 regulates activator protein 1 by direct phosphorylation of c-Jun
    Matjaz Humar
    Center for Clinical Research, Department of Anesthesiology, University Hospital Freiburg, Breisacherstrasse 66, D 79106 Freiburg, Germany
    Int J Biochem Cell Biol 39:2278-88. 2007
    The involvement of p38 in fundamental physiological processes and the fact that deregulation often leads to disease indicates the potential impact of p38 dependent mechanisms...
  33. ncbi Hepatitis C virus and HIV envelope proteins collaboratively mediate interleukin-8 secretion through activation of p38 MAP kinase and SHP2 in hepatocytes
    Anuradha Balasubramanian
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    J Biol Chem 278:35755-66. 2003
    ..Both specific inhibitors of p38 MAP kinase and sodium vanadate, a potent protein-tyrosine phosphatase inhibitor, blocked IL-8 production in a dose-..
  34. ncbi Lack of the leukocyte-associated Ig-like receptor-1 expression in high-risk chronic lymphocytic leukaemia results in the absence of a negative signal regulating kinase activation and cell division
    A Poggi
    Laboratory of Experimental Oncology D, National Institute for Cancer Research, Genoa, Italy
    Leukemia 22:980-8. 2008
    ..Constitutive activation of c-Jun aminoterminal kinase (JNK), p38 mitogen-activated protein kinase and extracellular signal-regulated kinase, has been reported in CLL...
  35. ncbi Role of Smad2/3 and p38 MAP kinase in TGF-β1-induced epithelial-mesenchymal transition of pulmonary epithelial cells
    Irina Kolosova
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Cell Physiol 226:1248-54. 2011
    ..To test this hypothesis, we studied the roles and mechanisms of TGF-β1-induced Smad and p38 mitogen-activated protein kinase (MAPK) signaling in EMT-related changes in pulmonary epithelial cells...
  36. ncbi Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions
    T Tanoue
    Department of Biophysics, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    EMBO J 20:466-79. 2001
    ..However, the CD domain alone does not determine the docking specificity. Here we have identified a novel site on p38 and ERK2 MAPKs that regulates the docking specificity towards MAPKAPKs...
  37. ncbi ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts
    Indira Prasadam
    Queensland University of Technology, Brisbane, Queensland, Australia
    Arthritis Rheum 62:1349-60. 2010
    ..The aim of this study was to investigate the in vitro effects of OA SBOs on the phenotypical changes in normal ACCs and to unveil the potential involvement of MAPK signaling pathways during this process...
  38. ncbi VCAM-1 upregulation via PKCdelta-p38 kinase-linked cascade mediates the TNF-alpha-induced leukocyte adhesion and emigration in the lung airway epithelium
    Chang Hoon Woo
    School of Life Sciences and Biotechnology, Korea University, 5 1 Anam dong, Sungbuk Gu, Seoul, 136 701, Korea
    Am J Physiol Lung Cell Mol Physiol 288:L307-16. 2005
    ..In addition, TNF-alpha was shown to induce the expression of VCAM-1 in a p38 kinase-dependent manner; also, TNF-alpha-induced p38 kinase activation was blocked by inhibition of PKCdelta, ..
  39. ncbi Nox4 mediates the expression of plasminogen activator inhibitor-1 via p38 MAPK pathway in cultured human endothelial cells
    Amandine Jaulmes
    Division of Angiology, Servier Research Institute, 11 rue des Moulineaux, Suresnes, France
    Thromb Res 124:439-46. 2009
    ..The aim of the present study was to characterize the role of NADPH oxidase and in particular Nox4 in the regulation of PAI-1 expression in cultured Human Umbilical Venous Endothelial Cells (HUVECs)...
  40. ncbi Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes
    Nastiti Wijayanti
    Institut für Klinische Immunologie und Transfusionsmedizin, Justus Liebig Universitat Giessen, Langhanstrasse 7, D 35392 Giessen, Germany
    J Biol Chem 280:21820-9. 2005
    ..AEBSF activated the mitogen-activated protein kinases (MAPK) JNK and p38. Inhibition of p38alpha and p38beta, but not that of JNK or p38gamma and p38delta, prevented the induction of HO-1 gene expression by ..
  41. ncbi Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase
    Thomais Markou
    Laboratory of Animal Physiology, Department of Zoology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
    Biochem J 365:757-63. 2002
    ..Maximal activation of MSK1 in adult cardiomyocytes temporally coincided with maximal p38 MAPK activation while activation of the extracellular-signal-regulated kinase (ERK) cascade was more rapid...
  42. ncbi p38 MAPK and ERK activation by 9-cis-retinoic acid induces chemokine receptors CCR1 and CCR2 expression in human monocytic THP-1 cells
    Jesang Ko
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    Exp Mol Med 39:129-38. 2007
    ..up-regulation of CCR1 and CCR2 in 9CRA-stimulated cells were weakly blocked by the pretreatment of SB202190, a p38 MAPK inhibitor, and PD98059, an upstream ERK inhibitor...
  43. ncbi Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells
    Hye Jung Kang
    College of Pharmacy, Duksung Women s University, 4129 Ssangmun dong, Tobong ku, Seoul 132 714, Korea
    Int J Cancer 103:475-82. 2003
    ..In H-ras MCF10A cells, capsaicin treatment markedly activated c-Jun N-terminal protein kinase (JNK)-1 and p38 matigen-activated protein kinase (MAPK) while it deactivated extracellular signal-regulated protein kinases (ERKs)...
  44. ncbi Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor
    Pallavi S Peter
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Clin Invest 117:1335-43. 2007
    We examined the role of p38alpha MAPK in mediating cardiomyopathy in mice overexpressing beta(1)-adrenergic receptor (beta(1)-AR) or beta(2)-AR by mating them with dominant-negative p38alpha (DNp38alpha) MAPK mice...
  45. ncbi STAT3, p38 MAPK, and NF-kappaB drive unopposed monocyte-dependent fibroblast MMP-1 secretion in tuberculosis
    Cecilia M O'Kane
    Department of Infectious Diseases and Immunity, Hammersmith Campus, Imperial College London, London, United Kingdom
    Am J Respir Cell Mol Biol 43:465-74. 2010
    ..MMP-1 up-regulation and TIMP-1 down-regulation were p38 (but not extracellular signal-regulated kinase or c-Jun N-terminal kinase) mitogen-activated protein kinase-..
  46. ncbi Toll-like receptor 4 regulates heme oxygenase-1 expression after hemorrhagic shock induced acute lung injury in mice: requirement of p38 mitogen-activated protein kinase activation
    Chang Chen
    Department of Anesthesiology, Zhongnan Hospital, Medical College of Wuhan University, Wuhan, Hubei, People s Republic of China
    Shock 31:486-92. 2009
    ..Arterial blood gases; expressions of TLR-4, heme oxygenase 1 (HO-1), and p38 mitogen-activated protein kinase (p38MAPK); myeloperoxidase activity; lung wet/dry ratios; and IL-10 levels in lung ..
  47. ncbi ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling
    Y Sano
    Laboratory of Molecular Genetics, Tsukuba Life Science Center, RIKEN, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    J Biol Chem 274:8949-57. 1999
    ..activity is enhanced after phosphorylation by stress-activated protein kinases such as c-Jun N-terminal kinase and p38. The binding between ATF-2 and Smad3/4 is mediated via the MH1 region of the Smad proteins and the basic leucine ..
  48. ncbi A novel protein kinase A-independent, beta-arrestin-1-dependent signaling pathway for p38 mitogen-activated protein kinase activation by beta2-adrenergic receptors
    Kaizheng Gong
    Institute of Vascular Medicine, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, China
    J Biol Chem 283:29028-36. 2008
    A growing body of evidence has demonstrated that p38 mitogen-activated protein kinase (MAPK) has a crucial role in various physiological and pathological processes mediated by beta(2)-adrenergic receptors (beta(2)-ARs)...
  49. ncbi Tumor necrosis factor-alpha upregulates 11beta-hydroxysteroid dehydrogenase type 1 expression by CCAAT/enhancer binding protein-beta in HepG2 cells
    Irena D Ignatova
    Depts of Nephrology and Hypertension and Clinical Research, Freiburgstrasse 15, Univ Hospital, Berne, CH 3010 Berne, Switzerland
    Am J Physiol Endocrinol Metab 296:E367-77. 2009
    ..We found that TNF-alpha acts via p38 MAPK pathway...
  50. ncbi Differential induction of interleukin-10 in monocytes by HIV-1 clade B and clade C Tat proteins
    Justine K Wong
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:18319-25. 2010
    ..Moreover, we show that p38alpha/p38beta and phosphoinositide 3-kinase are crucial to Tat-induced IL-10 production...
  51. ncbi Cell growth of ovarian cancer cells is stimulated by xenoestrogens through an estrogen-dependent pathway, but their stimulation of cell growth appears not to be involved in the activation of the mitogen-activated protein kinases ERK-1 and p38
    Se Hyung Park
    Department of Obstetrics and Gynecology, British Columbia Women s Hospital, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    J Reprod Dev 55:23-9. 2009
    ..BPA rapidly induced activation of extracellular signal-regulated kinase (ERK) 1/2 and p38 MAPK at 15 min, but the effect of BPA (10 microM) on stimulation of cell growth was not blocked by pretreatment ..
  52. ncbi Involvement of connexin 43 in angiotensin II-induced migration and proliferation of saphenous vein smooth muscle cells via the MAPK-AP-1 signaling pathway
    Guanghong Jia
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    J Mol Cell Cardiol 44:882-90. 2008
    ..The effect of angiotensin II was blocked by siRNA of ERK 1/2, p38 MAPK and JNK, respectively. Overexpression of Cx43 markedly increased the proliferation of saphenous vein SMCs...
  53. ncbi Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway
    Jennifer A Markovics
    Department of Pathology, Pulmonary Division, School of Medicine, University of California, San Francisco, California 94110, USA
    J Biol Chem 285:24695-706. 2010
    ..expression and that Sp1, Sp3, and several AP-1 transcription factors form a complex that binds to these sites in a p38-dependent manner...
  54. ncbi Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus
    Ying Liao
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    Virology 420:106-16. 2011
    ..The results showed that IBV infection of cultured human and animal cells activated the p38 mitogen-activated protein kinase (MAPK) pathway and induced the expression of IL-6 and IL-8...
  55. ncbi Reactive oxygen species-activated p38/ERK 1/2 MAPK signaling pathway in the Mycobacterium bovis bacillus Calmette Guérin (BCG)-induced CCL2 secretion in human monocytic cell line THP-1
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, IPN, Mexico, D F, Mexico
    Arch Med Res 41:579-85. 2010
    ....
  56. ncbi Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines
    Rosa A Cardone
    Department of General and Environmental Physiology, University of Bari, 70126 Bari, Italy
    Mol Biol Cell 16:3117-27. 2005
    ....
  57. ncbi Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1
    D N Slack
    Imperial Cancer Research Fund Molecular Pharmacology Unit, Biomedical Research Centre, Level 5, Ninewells Hospital, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 276:16491-500. 2001
    ..that MKP-1 is able to interact selectively with the extracellular signal-regulated kinase 1/2 (ERK1/2), p38alpha, and c-Jun NH(2)-terminal kinase (JNK) MAP kinase isoforms...
  58. ncbi Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type 1 responses
    Hermann R Bohnenkamp
    Cancer Research UK, Breast Cancer Biology Group, Thomas Guy House, 3rd Floor, Guy s Hospital, London SE1 9RT, UK
    Cell Immunol 247:72-84. 2007
    ..activation of nuclear factor-kappaB (NF-kappaB) and mitogen activated protein kinases (MAPK) such as SAPK/JNK and p38 MAPK and the interferon (IFN) dependent pathway that signals via TRIF and results in the production of IFN-alpha/..
  59. ncbi Hierarchical phosphorylation of the translation inhibitor 4E-BP1
    A C Gingras
    Department of Biochemistry and McGill Cancer Centre, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Genes Dev 15:2852-64. 2001
    ..Finally, we show that phosphorylation of Ser 65 and Thr 70 alone is insufficient to block binding to eIF4E, indicating that a combination of phosphorylation events is necessary to dissociate 4E-BP1 from eIF4E...
  60. ncbi Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light
    Tamara Tanos
    Laboratorio de Fisiologia y Biologia Molecular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIBYNE CONICET, 1428 Buenos Aires, Argentina
    J Biol Chem 280:18842-52. 2005
    ..Using a specific pharmacological inhibitor for p38alpha and -beta, we found that most likely these two isoforms mediate UV-induced c-Fos phosphorylation in vivo...
  61. ncbi Vascular cell adhesion molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/MAPK/NF-kappaB: inhibitory role of curcumin
    David G Binion
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Physiol Gastrointest Liver Physiol 297:G259-68. 2009
    ..expression in HIMEC was suppressed by Akt small-interfering RNA, curcumin, and inhibitors of NF-kappaB (SN-50), p38 MAPK (SB-203580) and PI 3-kinase/Akt (LY-294002)...
  62. ncbi Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38alpha
    Feng Hao
    Department of Pathobiology, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN 37996, USA
    Biochim Biophys Acta 1771:883-92. 2007
    ..of p38 MAPK isotypes of alpha, beta, gamma and delta, we have identified that the activation of ERK2 (p42) and p38alpha, but not of ERK1 and the other isoforms of p38 MAPK, is required for LPA-induced migration...
  63. ncbi cAMP targeting of p38 MAP kinase inhibits thrombin-induced NF-kappaB activation and ICAM-1 expression in endothelial cells
    Arshad Rahman
    Department of Pediatrics, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Am J Physiol Lung Cell Mol Physiol 287:L1017-24. 2004
    ..Because p38 MAPK can induce transcriptional activity of RelA/p65 without altering the DNA binding function of NF-kappaB, we ..
  64. ncbi Morphine potentiates HIV-1 gp120-induced neuronal apoptosis
    Shuxian Hu
    Division of Infectious Diseases and International Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    J Infect Dis 191:886-9. 2005
    ..mechanism whereby morphine potentiates gp120(IIIB)-induced neuronal apoptosis appears to involve activation of the p38 mitogen-activated protein kinase intracellular signaling pathway and microglial cells dispersed within the neuronal/..
  65. ncbi Identification of extracellular signal-regulated kinase 1/2 and p38 MAPK as regulators of human sperm motility and acrosome reaction and as predictors of poor spermatozoan quality
    Tal Almog
    Department of Biochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
    J Biol Chem 283:14479-89. 2008
    ..Here we report that ERK1/2 and p38 MAPK are primarily localized to the tail of mature human spermatozoa...
  66. ncbi Target gene specificity of USF-1 is directed via p38-mediated phosphorylation-dependent acetylation
    Sébastien Corre
    Signaling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted RH8 OTL, United Kingdom
    J Biol Chem 284:18851-62. 2009
    ..Following UV irradiation, USF-1 is phosphorylated by the p38 stress-activated kinase on threonine 153 and directly up-regulates expression of the POMC, MC1R, TYR, TYRP-1 and ..
  67. ncbi Herpes simplex virus type 1 ICP27 induces p38 mitogen-activated protein kinase signaling and apoptosis in HeLa cells
    Peter A Gillis
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, 55455, USA
    J Virol 83:1767-77. 2009
    ..viral replication including host shutoff, viral gene expression, activation of mitogen-activated protein kinases p38 and Jun N-terminal protein kinase (JNK), and apoptosis inhibition...
  68. ncbi HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways
    ChuHee Lee
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Leukoc Biol 78:1016-23. 2005
    ..mitogen-activated protein kinases (MAPK) extracellular signal-regulated kinase 1/2 (ERK-1/2; PD98059, U0126) and p38 (SB202190, PD169316) inhibited the secretion of TNF-alpha...
  69. ncbi Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis
    Gaetane Mace
    European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 24:3235-46. 2005
    ..of an activated mutant of Rab5 stimulated endocytosis of MOR ligand-independently in wild-type but not in p38alpha-/- cells...
  70. ncbi Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus
    Vigdis Sørensen
    Centre for Cancer Biomedicine, Faculty Division Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Mol Cell Biol 28:4129-41. 2008
    ..translocation was inhibited after chemical inhibition of p38 MAPK or after small interfering RNA knockdown of p38alpha. Translocation was increased after stimulation of p38 MAPK with anisomycin, mannitol, or H2O2...
  71. ncbi p38 mitogen-activated protein kinase stimulates estrogen-mediated transcription and proliferation through the phosphorylation and potentiation of the p160 coactivator glucocorticoid receptor-interacting protein 1
    Daniel E Frigo
    Molecular and Cellular Biology Program, Center for Bioenvironmental Research, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Mol Endocrinol 20:971-83. 2006
    ..Here, we demonstrate that the p38 MAPK stimulates both ERalpha- and ERbeta-mediated transcription in MCF-7 breast carcinoma, Ishikawa endometrial ..
  72. ncbi IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells
    Huei Ting Yang
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Sir James Black Centre, Dow Street, Dundee, DD1 5EH, United Kingdom
    Cell Signal 20:375-80. 2008
    ..Specific inhibition of p38alpha MAP kinase or preventing the activation of ERK1/ERK2 partially reduced the production of these substances, while ..
  73. ncbi Signal transducer and activator of transcription factor 1 mediates apoptosis induced by hepatitis C virus and HIV envelope proteins in hepatocytes
    Anuradha Balasubramanian
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA
    J Infect Dis 194:670-81. 2006
    ..Moreover, inhibitor studies indicated that Lyn kinase, p38 mitogen-activated protein kinase, and protein kinase C delta might be involved in STAT1 phosphorylation...
  74. ncbi Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells
    Richard M Ogborne
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, CB1 9NL, UK
    Arterioscler Thromb Vasc Biol 25:2100-5. 2005
    ..This study examined the effects of ALA on HO-1 expression in human monocytic cells...
  75. ncbi p38alpha isoform Mxi2 binds to extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase and regulates its nuclear activity by sustaining its phosphorylation levels
    Victoria Sanz-Moreno
    Departamento de Biologia Molecular, Universidad de Cantabria, Santander 39011, Spain
    Mol Cell Biol 23:3079-90. 2003
    Mxi2 is a p38alpha splice isoform that is distinctively activated by mitogenic stimuli...
  76. ncbi Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation
    Nam On Ku
    Department of Medicine, and Geriatric Research, Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Biol Chem 277:10775-82. 2002
    ..Here we show that Ser-73 is exclusively phosphorylated in vitro by p38 mitogen-activated protein kinase...
  77. ncbi Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
    J Han
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 386:296-9. 1997
    ..In mammalian cells the MAPK p38 is thought to play an important role in the regulation of cellular responses during infection through its effects ..
  78. ncbi A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
    L Tong
    Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut 06877, USA
    Nat Struct Biol 4:311-6. 1997
    The crystal structure of human p38 mitogen-activated protein (MAP) kinase in complex with a potent and highly specific pyridinyl-imidazole inhibitor has been determined at 2.0 A resolution...
  79. ncbi The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase
    S Katz
    Department of Molecular Genetics and the Rappaport Family Institute for Research in the Medical Sciences and the B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O Box 9649, Bat Galim, 31096, Haifa, Israel
    FEBS Lett 506:196-200. 2001
    ..Our data indicate that JDP2 is a bona fide substrate for the c-Jun N-terminal kinase. The precise role of JDP2 phosphorylation on its function is not yet known...
  80. ncbi Hypoxia activates beta(1)-integrin via ERK 1/2 and p38 MAP kinase in human vascular smooth muscle cells
    Florian Blaschke
    Deutsches Herzzentrum Berlin, Department of Cardiology, Augustenburger Platz 1, 13353 Berlin, Germany
    Biochem Biophys Res Commun 296:890-6. 2002
    ..of the pharmacological ERK 1/2 mitogen-activated protein kinase (MAPK) pathway inhibitor PD98059 (30 microM) or the p38 MAPK inhibitor SB203580 (1 microM)...
  81. ncbi Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein
    A S Zervos
    Cutaneous Biology Research Center, Massachusetts General Hospital Harvard Medical School, Charlestown, USA
    Proc Natl Acad Sci U S A 92:10531-4. 1995
    We describe Mxi2, a human protein that interacts with Max protein, the heterodimeric partner of the Myc oncoprotein...
  82. ncbi Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes
    Abdelhamid Liacini
    Département de Médecine and Centre de Recherche du Centre Hospitalier de l Université de Montréal, Hôpital Notre Dame du CHUM, 1560 Sherbrooke Est, Montreal, Quebec, Canada H2L 4M1
    Matrix Biol 21:251-62. 2002
    ..IL-1 rapidly induced the activation of extracellular-signal regulated kinase (ERK), protein 38 (p38) and c-Jun N-terminal kinase (JNK) MAPKs in the first-passage human femoral head OA chondrocytes...
  83. ncbi Isolation of hyperactive mutants of the MAPK p38/Hog1 that are independent of MAPK kinase activation
    M Bell
    Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Biol Chem 276:25351-8. 2001
    ..Equivalent mutations, introduced to the human p38alpha, rendered the enzyme active even when produced in Escherichia coli, showing that the mutations increased the ..
  84. ncbi Nuclear factor-kappa B activation by the CXC chemokine melanoma growth-stimulatory activity/growth-regulated protein involves the MEKK1/p38 mitogen-activated protein kinase pathway
    D Wang
    Department of Veterans Affairs, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 276:3650-9. 2001
    ..as well as mitogen-activated protein (MAP) kinase kinase kinase (MEKK) 1, MAP kinase kinase (MEK) 3/6, and p38 MAP kinase activation...
  85. ncbi Hypoxia induces apoptosis by caspase activation accompanying cytochrome C release from mitochondria in MC3T3E1 osteoblasts. p38 MAPK is related in hypoxia-induced apoptosis
    H J Chae
    Department of Dental Pharmacology and Wonkwang Dental Reseaarch Institute, School of Dentistry, Wonkwang University, South Korea
    Immunopharmacol Immunotoxicol 23:133-52. 2001
    ..Furthermore, we have observed that pre-treatment with SB203580, a selective p38 MAP kinase (p38 MAPK) inhibitor, attenuated the hypoxia-induced apoptosis...
  86. ncbi Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation
    J Buteau
    Molecular Nutrition Unit, Department of Nutrition, University of Montreal, the Centre de Recherche du CHUM and Institut du Cancer, Montreal, Quebec, Canada
    Diabetes 50:2237-43. 2001
    ..GLP-1 increased extracellular signal-related kinase 1/2, p38 mitogen-activated protein kinase (MAPK), and protein kinase B activities nonadditively with glucose in pancreatic ..
  87. ncbi The small GTP-binding protein rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells. Evidence for a Pak-independent signaling pathway
    H Teramoto
    Laboratory of Cellular Development and Oncology, NIDR, National Institutes of Health, Bethesda, Maryland 20892 4330, USA
    J Biol Chem 271:25731-4. 1996
    ..extracellular signal-regulated kinases (ERKs), also known as MAPKs; c-Jun N-terminal kinases (JNKs); and p38 kinase...
  88. ncbi The activation of ERK1/2 and p38 mitogen-activated protein kinases is dynamically regulated in the developing rat visual system
    Camila Salum Oliveira
    Laboratório de Neuroquímica 3, Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil
    Int J Dev Neurosci 26:355-62. 2008
    ..Kojic, L.Z., Zhang, L., Prasad, S.S., Douglas, R., Wang, Y., Cynader, M.S., 2006. Anisomycin activates p38 MAP kinase to induce LTD in mouse primary visual cortex. Brain Res. 1085, 68-76]...
  89. ncbi Glial phosphorylated p38 MAP kinase mediates pain in a rat model of lumbar disc herniation and induces motor dysfunction in a rat model of lumbar spinal canal stenosis
    Toshinori Ito
    Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 32:159-67. 2007
    ..Immunohistochemical and behavioral study using rat models of lumbar disc herniation and cauda equina syndrome...
  90. ncbi Thyroid-stimulating hormone and cyclic AMP activate p38 mitogen-activated protein kinase cascade. Involvement of protein kinase A, rac1, and reactive oxygen species
    M Pomerance
    Unité 486 INSERM, Transduction Hormonale et Régulation Cellulaire, Faculte de Pharmacie, 92296 Chatenay Malabry, France
    J Biol Chem 275:40539-46. 2000
    b>p38 mitogen-activated protein kinases (p38-MAPKs) are activated by cytokines, cellular stresses, growth factors, and hormones. We show here that p38-MAPKs are activated upon stimulation by thyroid-stimulating hormone (TSH) or cAMP...
  91. ncbi Endotoxin-induced activation of equine digital vein endothelial cells: role of p38 MAPK
    Andrew C Brooks
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA, UK
    Vet Immunol Immunopathol 129:174-80. 2009
    ..endotoxin (lipopolysaccharide; LPS) to endothelium initiates a range of signalling events, including activation of p38 mitogen activated protein kinases (MAPKs) that are involved in the initiation of inflammatory responses...
  92. ncbi Variations of p38 MAPK and sICAM-1 with therapeutic effect of different resuscitation fluids on severe traumatic patients
    Mei Bing
    Emergency Department, First Affiliated Hospital, Second Military Medical University, Shanghai 200433, China
    Chin J Traumatol 10:263-8. 2007
    To investigate the dynamic variation and action mechanism of sICAM-1 and p38 mitogen-activated protein kinases (MAPK) signal transduction in human severe trauma and resuscitation, as well as the effect of lactated Ringer's solution(LR), ..
  93. ncbi ERK1/2 and p38 mitogen-activated protein kinase mediate iNOS-induced spinal neuron degeneration after acute traumatic spinal cord injury
    Zhen Xu
    Institute of Neurosciences, The Fourth Military Medical University, Xi an, 710032, PR China
    Life Sci 79:1895-905. 2006
    ..the synthesis and release of NO, we examined activation of extracellular signal regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinases (p38 MAPK) in microglia/macrophages in the injured area of adult rats subjected ..
  94. ncbi Effect of NF-kappaB and p38 MAPK in activated monocytes/macrophages on pro-inflammatory cytokines of rats with acute pancreatitis
    Hong Shan Liu
    Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi an Jiaotong University, Xi an 710061, Shaanxi Province, China
    World J Gastroenterol 9:2513-8. 2003
    ..through two major signaling pathways at the level of proteins: nuclear transcription factor-kappaB (NF-kappaB) and p38 mitogen-activated protein kinase (p38 MAPK)...
  95. ncbi Altering dietary nutrient intake that reduces glycogen content leads to phosphorylation of nuclear p38 MAP kinase in human skeletal muscle: association with IL-6 gene transcription during contraction
    M H Stanley Chan
    Skeletal Muscle Research Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology, Bundoora, Victoria, Australia
    FASEB J 18:1785-7. 2004
    ..and analyzed for the mitogen- activated protein kinases (MAPK) c-jun amino-terminal kinase (JNK) 1 and 2 and p38 MAPK...
  96. ncbi Activation of p38 mitogen-activated protein kinase (p38 MAPK), extracellular signal-regulated kinase (ERK) and c-jun N-terminal kinase (JNK) during hypoxia in cerebral cortical nuclei of guinea pig fetus at term: role of nitric oxide
    Dev Maulik
    Department of Obstetrics and Gynecology, University of Missouri, Kansas City, Hospital Hill Building, Truman Medical Center, 2301 Holmes Street, Kansas City, MO 64108, United States
    Neurosci Lett 439:94-9. 2008
    ..methyl ester (L-NAME), a NOS inhibitor, prior to hypoxia prevents the hypoxia-induced activation of p38 mitogen-activated protein kinase (p38 MAPK), extracellular signal-regulated kinase (ERK) and c-jun N-terminal ..
  97. ncbi Chronic exposure of human mesangial cells to high glucose environments activates the p38 MAPK pathway
    W A Wilmer
    Nephrology Division, Department of Internal Medicine, Heart Lung Research Institute, The Ohio State University College of Medicine, Columbus, Ohio, USA
    Kidney Int 60:858-71. 2001
    ..The p38 MAPK pathway is activated by events that occur in the setting of diabetes, such as protein kinase C (PKC) up-..
  98. ncbi Inhibition of myocardial apoptosis by ischaemic and beta-adrenergic preconditioning is dependent on p38 MAPK
    Johannes A Moolman
    Department of Medical Physiology and Biochemistry, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Republic of South Africa
    Cardiovasc Drugs Ther 20:13-25. 2006
    ..ischaemia /reperfusion contributes independently to tissue damage, and involves activation of the stress-kinase, p38 MAPK during reperfusion...
  99. ncbi A role for the p38 mitogen-activated protein kinase/Hsp 27 pathway in cholecystokinin-induced changes in the actin cytoskeleton in rat pancreatic acini
    C Schafer
    Department of Physiology and Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0622, USA
    J Biol Chem 273:24173-80. 1998
    ..CCK and osmotic stress induced by sorbitol activated p38 MAP kinase within minutes; their effects were dose-dependent, with maximal activation of 2.8- and 4.4-fold, respectively...
  100. ncbi Hypotonic shock mediation by p38 MAPK, JNK, PKC, FAK, OSR1 and SPAK in osmosensing chloride secreting cells of killifish opercular epithelium
    W S Marshall
    Department of Biology, St Francis Xavier University, PO Box 5000 Antigonish, Nova Scotia, Canada B2G 2W5
    J Exp Biol 208:1063-77. 2005
    ..Gö6976 that selectively blocks PKC alpha and beta subtypes, H-89 that blocks PKA, SB203580 that blocks p38 mitogen-activated protein kinase (MAPK), as well as serine/threonine protein phosphatase (PP1 and 2A) inhibitor ..
  101. ncbi [The effects of p38 mitogen activated protein kinase inhibitor SB203580 on colonic mucosa tumor necrosis factor alpha expression in ulcerative colitis]
    Wen Quan Yi
    Department of Gastroenterology, West China Hospital of Sichuan University, Chengdu 610041, China
    Zhonghua Nei Ke Za Zhi 46:747-50. 2007
    To investigate the expression of phosphorylated p38 mitogen activated protein kinase (MAPK) in colonic mucosa of patients with ulcerative colitis (UC) and the effects of SB203580 which is a p38 MAPK inhibitor on the secretion of TNFalpha ..

Research Grants72

  1. Regulation of airway epithelial repair
    Steven R White; Fiscal Year: 2010
    ..cytokines activate specific signaling pathways that activate the mitogen-activated protein kinases (MAPKs), such as p38 MARK and JNK, that in turn initiate early steps in the migration of airway epithelial cells to cover damaged ..
  2. Regulation of airway epithelial repair
    Steven White; Fiscal Year: 2006
    ..cytokines activate specific signaling pathways that activate the mitogen-activated protein kinases (MAPKs), such as p38 MARK and JNK, that in turn initiate early steps in the migration of airway epithelial cells to cover damaged ..
  3. Regulation of airway epithelial repair
    Steven White; Fiscal Year: 2007
    ..cytokines activate specific signaling pathways that activate the mitogen-activated protein kinases (MAPKs), such as p38 MARK and JNK, that in turn initiate early steps in the migration of airway epithelial cells to cover damaged ..
  4. Role of Signal Transduction in Burn and Wound Healing
    Saman Arbabi; Fiscal Year: 2006
    ..We have focused on p38 and ERK, two important MAPK families, regulating inflammatory response and apoptosis...
  5. Reactive Oxygen Species in Coronary Collateral Growth
    William M Chilian; Fiscal Year: 2010
    ..Aim 4. Determine the cell type where expression of a constitutively active p38 MAP kinase will restore collateral growth in the JCR rat...
  6. Reactive Oxygen Species in Coronary Collateral Growth
    WILLIAM CHILIAN; Fiscal Year: 2009
    ..Aim 4. Determine the cell type where expression of a constitutively active p38 MAP kinase will restore collateral growth in the JCR rat...
  7. Transcription & Function of Adipocyte Beta3AR in Obesity
    Sheila Collins; Fiscal Year: 2006
    ..Aims proposed: (1) to characterize the signal transduction pathway linking the betaARs in adipocytes to the p38 MAP kinase; to test the hypothesis that Rac1/Cdc42 and the MLKs are activated by PKA and, in turn, directly activate MKK3/..
  8. p38 MAP kinase in early thymocyte development
    Mercedes Rincon; Fiscal Year: 2009
    The p38 MAP kinase (MAPK) pathway is activated in response to stress stimuli (e.g...
  9. p38 MAP kinase in early thymocyte development
    Mercedes Rincon; Fiscal Year: 2010
    The p38 MAP kinase (MAPK) pathway is activated in response to stress stimuli (e.g...
  10. P38 MAP KINASE SIGNALING IN SKIN
    Tatiana Efimova; Fiscal Year: 2010
    ..The p38 MAPK family members function in a cell type-specific and cell context-specific manner to regulate cell ..
  11. Role of p38 MAPK in IL-4-induced IL-6 expression in vascular endothelium
    Yongwoo Lee; Fiscal Year: 2007
    ..the proposed project, we hypothesize that IL-4 may induce inflammatory pathways in vascular endothelium through the p38 MAPK-mediated up-regulation of IL-6 expression...
  12. MECHANISMS OF THROMBIN INDUCED TOLERANCE TO BRAIN INJURY
    Guohua Xi; Fiscal Year: 2002
    ..may be associated with heat shock protein (HSP) 27 and/or colligin induction; 3) TPC activates p38 mitogen activated protein kinase (p38 MAP kinase) and extracellular signal regulated kinase (ERK) p44/42 MAP kinase; 4) TPC-induced ..
  13. Macrophage Foam Cells, Cathepsins and Cholesterol Efflux
    ALAN RICHARD TALL; Fiscal Year: 2010
    ..by binding of RANK ligand to RANK (Receptor Activator of NFkB) on macrophages and requiring activation of p38 MAP kinase. In Aim1 we will further define the relationship between different endosomal cholesterol pools, induction of ..
  14. Macrophage Foam Cells, Cathepsins and Cholesterol Efflux
    Alan Tall; Fiscal Year: 2007
    ..by binding of RANK ligand to RANK (Receptor Activator of NFkB) on macrophages and requiring activation of p38 MAP kinase. In Aim1 we will further define the relationship between different endosomal cholesterol pools, induction of ..
  15. ERYTHROPOIETIN AND THE REGULATION OF ERYTHROPOIESIS
    Sanford Krantz; Fiscal Year: 2003
    ..In addition, withdrawal of EPO activates the Jun N-terminal kinases (JNKs) and p38 MAP kinase which also produce apoptosis...
  16. Modulation of CNS Proinflammatory Cytokine Production
    Linda J Van Eldik; Fiscal Year: 2010
    ..proinflammatory cytokine overproduction and subsequent neuronal/synaptic damage, and that suppression of p38 MAPK signaling in the microglia and/or neuron can lead to selective, beneficial outcomes...
  17. Development of Novel p38 MAPK Inhibitors as Therapeutics for CNS Disorders
    DANIEL MARTIN WATTERSON; Fiscal Year: 2010
    ..This proposal tests the hypothesis that novel p38 MAPK inhibitors that are orally bioavailable, have good brain uptake, and are non-toxic can be developed into a new ..
  18. Development of Novel p38 MAPK Inhibitors as Therapeutics for CNS Disorders
    D Watterson; Fiscal Year: 2009
    ..This proposal tests the hypothesis that novel p38 MAPK inhibitors that are orally bioavailable, have good brain uptake, and are non-toxic can be developed into a new ..
  19. Role of p38 MAPK in HSC Self-Renewal and Radiation-Induced Bone Marrow Injury
    Daohong Zhou; Fiscal Year: 2009
    ..Recent studies from our laboratory and others suggest that p38 0-activated protein kinase (p38) is a negative regulator of HSC self- renewal and its activation may mediate IR-..
  20. Role of p38 MAPK in HSC Self-Renewal and Radiation-Induced Bone Marrow Injury
    Daohong Zhou; Fiscal Year: 2010
    ..Recent studies from our laboratory and others suggest that p38 0-activated protein kinase (p38) is a negative regulator of HSC self- renewal and its activation may mediate IR-..
  21. Epilepsy and dendritic excitability
    Nicholas P Poolos; Fiscal Year: 2010
    ..A novel modulator of HCN channel gating, p38 mitogen- activated kinase (p38 MAPK), was characterized as well, with inhibition of p38 MAPK causing downregulation ..
  22. The Role of Xanthine Oxidoreductase in Ventilator-Associated Lung Injury
    Paul M Hassoun; Fiscal Year: 2010
    ..and pharmacological inhibitors to test our hypotheses that the enzyme xanthine oxidoreductase (XOR) and the p38 MAP kinase signaling pathway play crucial roles in the pathogenesis of VALI, and anticipate that the studies proposed ..
  23. Urolithiasis: Oxalate Interactions with the Renal Cells
    Hari K Koul; Fiscal Year: 2010
    ..During the five year funding period, we demonstrated that oxalate and COM-crystals activate p38 MAP kinase pathway and NF-kB transcription factor...
  24. Urolithiasis: Oxalate Interactions with the Renal Cells
    Hari K Koul; Fiscal Year: 2010
    ..During the five year funding period, we demonstrated that oxalate and COM-crystals activate p38 MAP kinase pathway and NF-kB transcription factor...
  25. Urolithiasis: Oxalate Interactions with the Renal Cells
    Hari Koul; Fiscal Year: 2009
    ..During the five year funding period, we demonstrated that oxalate and COM-crystals activate p38 MAP kinase pathway and NF-kB transcription factor...
  26. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2003
    ..We have preliminary evidence for involvement of p38 MAP kinase in this pathway...
  27. Mechanisms For p38 MAP Kinase DependentT Gene Induction
    Betty Pace; Fiscal Year: 2004
    ..on this deduction, we initiated studies with two HDAIs sodium butyrate and trichosatin A and found both to activate p38 mitogen activating protein kinase (p38 MAPK) and activating transcription factor 2 (ATF-2)...
  28. p38 MAP Kinase and Akt Interaction in HUVEC
    Shehla Pervin; Fiscal Year: 2007
    ..umbilical vein endothelial cells (HUVEC) to stress, with emphasis on cross talk between PI-3 Kinase/Akt and p38 MAP Kinase pathways. It is found that male fetus has greater mortality rate than female...
  29. p38 MAPK in Ras-induced Senescence and Transformation
    Peiqing Sun; Fiscal Year: 2010
    The p38 MAPK pathway was initially identified as a mediator of inflammatory and stress responses. We and others have shown that this pathway also participates in tumor suppressing cellular responses such as oncogene-induced senescence...
  30. Novel Bioactive Lipid Receptors in Growth Regulation
    Yan Xu; Fiscal Year: 2005
    ..We hypothesize that p38 MAP kinase plays a critical role in mediating the growth inhibitory effect of SPC...
  31. Regulation of Neuronal Survival by the Rit GTPase
    DOUGLAS ALLEN ANDRES; Fiscal Year: 2010
    ..and neurotrophin-initiated signals, to activate a distinct pro-survival signaling cascade that relies upon p38 MAP kinase signaling...