p38

Summary

Gene Symbol: p38
Description: mitogen-activated protein kinase 14
Alias: CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, SAPK2A, p38, p38ALPHA, CSAID-binding protein, Csaids binding protein, MAP kinase 14, MAP kinase Mxi2, MAP kinase p38 alpha, MAX-interacting protein 2, cytokine suppressive anti-inflammatory drug binding protein, cytokine suppressive anti-inflammatory drug-binding protein, mitogen-activated protein kinase p38 alpha, p38 MAP kinase, p38 mitogen activated protein kinase, p38alpha Exip, stress-activated protein kinase 2A
Species: human

Top Publications

  1. pmc p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint
    Vanesa Lafarga
    CNIO Spanish National Cancer Center, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Mol Cell Biol 29:4341-51. 2009
  2. ncbi Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1
    P Puigserver
    Dana Farber Cancer Institute, Department of Cell Biology, Boston, MA 02115, USA
    Mol Cell 8:971-82. 2001
  3. ncbi Hepatitis C virus and HIV envelope proteins collaboratively mediate interleukin-8 secretion through activation of p38 MAP kinase and SHP2 in hepatocytes
    Anuradha Balasubramanian
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    J Biol Chem 278:35755-66. 2003
  4. pmc Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3
    Sofia Edlund
    Ludwig Institute for Cancer Research, Biomedical Centre, 75124 Uppsala, Sweden
    Mol Biol Cell 14:529-44. 2003
  5. ncbi Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1
    Masahito Matsumoto
    Department of Molecular Biology, Saitama Medical School, Saitama, Japan
    J Biol Chem 279:45969-79. 2004
  6. ncbi Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals
    Y Wu
    Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, People s Republic of China
    Oncogene 25:5787-800. 2006
  7. pmc Role of Smad2/3 and p38 MAP kinase in TGF-β1-induced epithelial-mesenchymal transition of pulmonary epithelial cells
    Irina Kolosova
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Cell Physiol 226:1248-54. 2011
  8. pmc Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt
    David Romano
    Proteomics and Signalling Networks Group, The Beatson Institute for Cancer Research, London, United Kingdom
    Cancer Res 70:1195-203. 2010
  9. doi Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus
    Ying Liao
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    Virology 420:106-16. 2011
  10. doi Lack of the leukocyte-associated Ig-like receptor-1 expression in high-risk chronic lymphocytic leukaemia results in the absence of a negative signal regulating kinase activation and cell division
    A Poggi
    Laboratory of Experimental Oncology D, National Institute for Cancer Research, Genoa, Italy
    Leukemia 22:980-8. 2008

Research Grants

  1. Regulation of airway epithelial repair
    Steven White; Fiscal Year: 2006
  2. Regulation of airway epithelial repair
    Steven R White; Fiscal Year: 2010
  3. Regulation of airway epithelial repair
    Steven White; Fiscal Year: 2007
  4. Role of Signal Transduction in Burn and Wound Healing
    Saman Arbabi; Fiscal Year: 2006
  5. Modulation of CNS Proinflammatory Cytokine Production
    Linda J Van Eldik; Fiscal Year: 2010
  6. Mechanisms For p38 MAP Kinase DependentT Gene Induction
    Betty Pace; Fiscal Year: 2004
  7. Reactive Oxygen Species in Coronary Collateral Growth
    William M Chilian; Fiscal Year: 2010
  8. Reactive Oxygen Species in Coronary Collateral Growth
    WILLIAM CHILIAN; Fiscal Year: 2009
  9. Transcription & Function of Adipocyte Beta3AR in Obesity
    Sheila Collins; Fiscal Year: 2006
  10. p38 MAP kinase in early thymocyte development
    Mercedes Rincon; Fiscal Year: 2010

Detail Information

Publications258 found, 100 shown here

  1. pmc p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint
    Vanesa Lafarga
    CNIO Spanish National Cancer Center, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Mol Cell Biol 29:4341-51. 2009
    Activation of p38 mitogen-activated protein kinase (MAPK) plays an important role in the G(2)/M cell cycle arrest induced by DNA damage, but little is known about the role of this signaling pathway in the G(1)/S transition...
  2. ncbi Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1
    P Puigserver
    Dana Farber Cancer Institute, Department of Cell Biology, Boston, MA 02115, USA
    Mol Cell 8:971-82. 2001
    ..These data illustrate a direct thermogenic action of cytokines and p38 MAP kinase through the transcriptional coactivator PGC-1.
  3. ncbi Hepatitis C virus and HIV envelope proteins collaboratively mediate interleukin-8 secretion through activation of p38 MAP kinase and SHP2 in hepatocytes
    Anuradha Balasubramanian
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    J Biol Chem 278:35755-66. 2003
    ..Both specific inhibitors of p38 MAP kinase and sodium vanadate, a potent protein-tyrosine phosphatase inhibitor, blocked IL-8 production in a dose-..
  4. pmc Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3
    Sofia Edlund
    Ludwig Institute for Cancer Research, Biomedical Centre, 75124 Uppsala, Sweden
    Mol Biol Cell 14:529-44. 2003
    ..prostate cancer PC-3U cells induced by TGF-beta1 or Smad7 overexpression is caused by a specific activation of the p38 mitogen-activated protein kinase pathway in a TGF-beta-activated kinase 1 (TAK1)- and mitogen-activated protein ..
  5. ncbi Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1
    Masahito Matsumoto
    Department of Molecular Biology, Saitama Medical School, Saitama, Japan
    J Biol Chem 279:45969-79. 2004
    ..report the regulatory mechanisms of RANKL-induced cathepsin K gene expression during osteoclastogenesis in a p38 MAP kinase-dependent manner...
  6. ncbi Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals
    Y Wu
    Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, People s Republic of China
    Oncogene 25:5787-800. 2006
    ..Overexpression of GSTP1-1 inhibited TRAF2-induced activation of both JNK and p38 but not of nuclear factor-kappaB (NF-kappaB)...
  7. pmc Role of Smad2/3 and p38 MAP kinase in TGF-β1-induced epithelial-mesenchymal transition of pulmonary epithelial cells
    Irina Kolosova
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Cell Physiol 226:1248-54. 2011
    ..To test this hypothesis, we studied the roles and mechanisms of TGF-β1-induced Smad and p38 mitogen-activated protein kinase (MAPK) signaling in EMT-related changes in pulmonary epithelial cells...
  8. pmc Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt
    David Romano
    Proteomics and Signalling Networks Group, The Beatson Institute for Cancer Research, London, United Kingdom
    Cancer Res 70:1195-203. 2010
    ..kinase but enhanced binding to tumor suppressor RASSF1A, accentuating downstream c-Jun NH(2)-terminal kinase and p38 mitogen-activated protein kinase signaling and promoting apoptosis...
  9. doi Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus
    Ying Liao
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    Virology 420:106-16. 2011
    ..The results showed that IBV infection of cultured human and animal cells activated the p38 mitogen-activated protein kinase (MAPK) pathway and induced the expression of IL-6 and IL-8...
  10. doi Lack of the leukocyte-associated Ig-like receptor-1 expression in high-risk chronic lymphocytic leukaemia results in the absence of a negative signal regulating kinase activation and cell division
    A Poggi
    Laboratory of Experimental Oncology D, National Institute for Cancer Research, Genoa, Italy
    Leukemia 22:980-8. 2008
    ..Constitutive activation of c-Jun aminoterminal kinase (JNK), p38 mitogen-activated protein kinase and extracellular signal-regulated kinase, has been reported in CLL...
  11. ncbi Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes
    Nastiti Wijayanti
    Institut für Klinische Immunologie und Transfusionsmedizin, Justus Liebig Universitat Giessen, Langhanstrasse 7, D 35392 Giessen, Germany
    J Biol Chem 280:21820-9. 2005
    ..AEBSF activated the mitogen-activated protein kinases (MAPK) JNK and p38. Inhibition of p38alpha and p38beta, but not that of JNK or p38gamma and p38delta, prevented the induction of HO-1 gene expression by ..
  12. pmc HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1
    Appakkudal R Anand
    Department of Pathology, Ohio State University, Columbus, OH 43210, USA
    Blood 114:3588-600. 2009
    ..analysis of the downstream signaling mechanisms involved in gp120-induced migration revealed that Pyk2 activates p38 mitogen-activated protein kinase, which in turn activates the F-actin-binding protein, leukocyte-specific protein 1,..
  13. doi Nox4 mediates the expression of plasminogen activator inhibitor-1 via p38 MAPK pathway in cultured human endothelial cells
    Amandine Jaulmes
    Division of Angiology, Servier Research Institute, 11 rue des Moulineaux, Suresnes, France
    Thromb Res 124:439-46. 2009
    ..The aim of the present study was to characterize the role of NADPH oxidase and in particular Nox4 in the regulation of PAI-1 expression in cultured Human Umbilical Venous Endothelial Cells (HUVECs)...
  14. pmc NSAID inhibition of prostate cancer cell migration is mediated by Nag-1 Induction via the p38 MAPK-p75(NTR) pathway
    Shehla Wynne
    Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, DC 20057, USA
    Mol Cancer Res 8:1656-64. 2010
    ..NSAIDs induce p75(NTR) through activation of the p38 mitogen-activated protein kinase (MAPK) pathway, with a concomitant decrease in cell survival...
  15. pmc Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
    D V Bulavin
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 18:6845-54. 1999
    Components of the ras signaling pathway contribute to activation of cellular p53. In MCF-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway...
  16. ncbi Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: role of mitogen-activated protein kinases and Nrf2
    Anila A Anwar
    Cardiovascular Division, GKT Schools of Biomedical Sciences and Medicine, King s College, University of London, Guy s Hospital Campus, London SE1 1UL, UK
    Free Radic Biol Med 39:227-36. 2005
    ..Inhibitors of protein kinase C (PKC) or mitogen-activated protein kinases (MAPK) p38(MAPK) and MEK or c-jun-NH2-terminal kinase (JNK) significantly attenuated induction of HO-1...
  17. pmc Human immunodeficiency virus type 1 Nef induces programmed death 1 expression through a p38 mitogen-activated protein kinase-dependent mechanism
    Karuppiah Muthumani
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Virol 82:11536-44. 2008
    ..Nef-induced PD-1 upregulation requires its proline-rich motif and the activation of the downstream kinase p38. Further, inhibition of Nef activity by p38 MAPK inhibitor effectively blocked PD-1 upregulation, suggesting that ..
  18. pmc Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope
    Jean Luc Perfettini
    Centre National Recherche Scientifique UMR8125, Institut Gustave Roussy, F 94805 Villejuif, France
    J Exp Med 201:279-89. 2005
    ..Cytoplasmic p38 mitogen-activated protein kinase (MAPK) was found to undergo an activating phosphorylation (p38T180/Y182P [p38 with ..
  19. doi Tumor necrosis factor-alpha regulates inflammatory and mesenchymal responses via mitogen-activated protein kinase kinase, p38, and nuclear factor kappaB in human endometriotic epithelial cells
    Eric M Grund
    EMD Serono Research Institute, One Technology Place, Rockland, MA 02190, USA
    Mol Pharmacol 73:1394-404. 2008
    ..nuclear factor kappaB, extracellular signal-regulated kinase > mitogen-activated protein kinase kinase (MEK), p38, and phosphatidylinositol 3-kinase (PI3K) > Akt1/2...
  20. ncbi HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways
    ChuHee Lee
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Leukoc Biol 78:1016-23. 2005
    ..mitogen-activated protein kinases (MAPK) extracellular signal-regulated kinase 1/2 (ERK-1/2; PD98059, U0126) and p38 (SB202190, PD169316) inhibited the secretion of TNF-alpha...
  21. pmc Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism
    A C Gingras
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Genes Dev 13:1422-37. 1999
    ..Taken together, our results suggest that 4E-BP1 phosphorylation by FRAP/mTOR on Thr-37 and Thr-46 is a priming event for subsequent phosphorylation of the carboxy-terminal serum-sensitive sites...
  22. ncbi IL-10 regulation by HIV-Tat in primary human monocytic cells: involvement of calmodulin/calmodulin-dependent protein kinase-activated p38 MAPK and Sp-1 and CREB-1 transcription factors
    Katrina Gee
    Department of Pathology and Laboratory Medicine, Division of Virology and Molecular Immunology, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario, Canada
    J Immunol 178:798-807. 2007
    ..in the calcium signaling suggested that calmodulin and calmodulin-dependent protein kinase-II (CaMK-II)-activated p38 MAPK played a role in extracellular Tat-induced IL-10 expression in primary human monocytes...
  23. ncbi Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes
    Abdelhamid Liacini
    Département de Médecine and Centre de Recherche du Centre Hospitalier de l Université de Montréal, Hôpital Notre Dame du CHUM, 1560 Sherbrooke Est, Montreal, Quebec, Canada H2L 4M1
    Matrix Biol 21:251-62. 2002
    ..IL-1 rapidly induced the activation of extracellular-signal regulated kinase (ERK), protein 38 (p38) and c-Jun N-terminal kinase (JNK) MAPKs in the first-passage human femoral head OA chondrocytes...
  24. ncbi p38alpha and p38delta mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells
    M R Junttila
    Deparment of Dermatology, University of Turku, Turku, Finland
    Oncogene 26:5267-79. 2007
    ..of p38 pathway component mRNA expression in HNSCC cell lines (n=42) compared to HEKs (n=8) revealed that p38alpha and p38delta isoforms are predominantly expressed in both cell types and that MKK3 is the primary upstream ..
  25. ncbi p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
    Juan Jose Ventura
    CNIO Spanish National Cancer Center, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Nat Genet 39:750-8. 2007
    Stem cell function is central for the maintenance of normal tissue homeostasis. Here we show that deletion of p38alpha mitogen-activated protein (MAP) kinase in adult mice results in increased proliferation and defective differentiation ..
  26. ncbi IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation
    Dolores M Cortez
    Department of Veterans Affairs South Texas Veterans Health Care System, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Am J Physiol Heart Circ Physiol 293:H3356-65. 2007
    ..and ELISA; transcriptional induction and transcription factor binding by EMSA, ELISA, and reporter assay; and p38 MAPK and ERK1/2 activation by protein kinase assays and Western blotting...
  27. ncbi The mitogen-activated protein kinase p38 regulates activator protein 1 by direct phosphorylation of c-Jun
    Matjaz Humar
    Center for Clinical Research, Department of Anesthesiology, University Hospital Freiburg, Breisacherstrasse 66, D 79106 Freiburg, Germany
    Int J Biochem Cell Biol 39:2278-88. 2007
    The involvement of p38 in fundamental physiological processes and the fact that deregulation often leads to disease indicates the potential impact of p38 dependent mechanisms...
  28. pmc Involvement of Kv1.3 and p38 MAPK signaling in HIV-1 glycoprotein 120-induced microglia neurotoxicity
    J Liu
    Neurophysiology Laboratory, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Cell Death Dis 3:e254. 2012
    ..3-siRNA abrogated gp120-associated microglia neurotoxic activity. Further investigation unraveled an involvement of p38 MAPK in gp120 enhancement of microglia K(v)1.3 expression and resultant neurotoxic activity...
  29. ncbi VCAM-1 upregulation via PKCdelta-p38 kinase-linked cascade mediates the TNF-alpha-induced leukocyte adhesion and emigration in the lung airway epithelium
    Chang Hoon Woo
    School of Life Sciences and Biotechnology, Korea University, 5 1 Anam dong, Sungbuk Gu, Seoul, 136 701, Korea
    Am J Physiol Lung Cell Mol Physiol 288:L307-16. 2005
    ..In addition, TNF-alpha was shown to induce the expression of VCAM-1 in a p38 kinase-dependent manner; also, TNF-alpha-induced p38 kinase activation was blocked by inhibition of PKCdelta, ..
  30. ncbi Crystal structure of p38 mitogen-activated protein kinase
    K P Wilson
    Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts 02139 4211, USA
    J Biol Chem 271:27696-700. 1996
    b>p38 mitogen-activated protein kinase is activated by environmental stress and cytokines and plays a role in transcriptional regulation and inflammatory responses...
  31. doi GEF-H1/RhoA signalling pathway mediates lipopolysaccharide-induced intercellular adhesion molecular-1 expression in endothelial cells via activation of p38 and NF-κB
    Feng Guo
    Department of Burn and Plastic Surgery, Shanghai Jiao Tong University, School of Medicine, Rui Jin Hospital, Shanghai 230022, China
    Cytokine 57:417-28. 2012
    ..Furthermore, pretreatment with Y-27632, an inhibitor of ROCK, significantly reduced LPS-induced p38, ERK1/2 and p65 phosphorylation, indicating that ROCK acts as an upstream effector of p38 and ERK1/2 to promote LPS-..
  32. doi HIV-1 proteins preferentially activate anti-inflammatory M2-type macrophages
    Takashi Chihara
    Center for AIDS Research, Kumamoto University, Kumamoto 860 0811, Japan
    J Immunol 188:3620-7. 2012
    ....
  33. doi Matched work high-intensity interval and continuous running induce similar increases in PGC-1α mRNA, AMPK, p38, and p53 phosphorylation in human skeletal muscle
    Jonathan D Bartlett
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom
    J Appl Physiol (1985) 112:1135-43. 2012
    ..Furthermore, this is the first report of contraction-induced p53 phosphorylation in human skeletal muscle, thus highlighting an additional pathway by which exercise may initiate mitochondrial biogenesis...
  34. ncbi HIV type 1 glycoprotein 120 inhibits human B cell chemotaxis to CXC chemokine ligand (CXCL) 12, CC chemokine ligand (CCL)20, and CCL21
    Gamal Badr
    Institut National de la Sante et de la Recherche Medicale, Unité 131, Institut Paris Sud sur les Cytokines, Clamart, France
    J Immunol 175:302-10. 2005
    ..Unlike CXCL12, gp120 did not induce the activation of phospholipase Cbeta3 and PI3K downstream from CXCR4, whereas p38 MAPK activation was observed...
  35. doi Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis
    Mustafa Zakkar
    British Heart Foundation Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Circ Res 103:726-32. 2008
    ..induce adhesion molecules (eg, vascular cell adhesion molecule [VCAM]-1) in endothelial cells (ECs) by activating p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein (MAP) kinases by phosphorylation...
  36. pmc Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphatase
    Robin J Dickinson
    Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital, Dundee DD1 9SY, Scotland, U K
    Biochem J 364:145-55. 2002
    ..extracellular signal-regulated kinases (ERKs) 1 and 2 and, to a lesser extent, the stress-activated MAPK p38alpha. These properties define the ability of this enzyme to dephosphorylate and inactivate ERK1/2 and p38alpha, but ..
  37. pmc Mitogen-activated protein kinases regulate LSF occupancy at the human immunodeficiency virus type 1 promoter
    Loyda Ylisastigui
    University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Y9 206a, Dallas, TX 75390 9113, USA
    J Virol 79:5952-62. 2005
    ..In vitro, phosphorylation of LSF by Erk decreases binding to the LTR, while binding is increased by p38 phosphorylation...
  38. ncbi Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta-induced IL-8 expression in human vascular smooth muscle cells
    Young D Jung
    Chonnam National University Research Institute of Medical Sciences, Hakdong 5, Kwangju, Korea
    Cytokine 18:206-13. 2002
    ..b>P38 mitogen-activated protein kinase (MAPK) was activated after 5min of IL-1beta treatment, whereas the extracellular ..
  39. pmc p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression
    J Westermarck
    Turku Centre for Biotechnology, University of Turku, University of Turku, FIN 20520 Turku, Finland
    Mol Cell Biol 21:2373-83. 2001
    ..Specific activation of p38alpha by adenovirus-delivered constitutively active MKK3b resulted in potent inhibition of the activity of ERK1,2 and ..
  40. ncbi HIV-1 glycoprotein 120 induces the MMP-9 cytopathogenic factor production that is abolished by inhibition of the p38 mitogen-activated protein kinase signaling pathway
    D Missé
    Laboratoire d Immunologie Rétrovirale et Moléculaire, the Institut de Recherche pour le Développement and the Centre National de la Recherche Scientifique, 240 Av E Jeanbrau, 34094 Montpellier, France
    Blood 98:541-7. 2001
    ..Thus, both p38 and SAPK/Jun N-terminal kinase mitogen-activated protein kinases (MAPKs) are activated on stimulation of these ..
  41. doi Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase
    Ian M Evans
    Centre for Cardiovascular Biology and Medicine, Department of Medicine, The Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, United Kingdom
    Cell Signal 20:1375-84. 2008
    ..migration and tubulogenesis, whereas inhibition of the p38 kinase pathway using either SB203580 or siRNAs against p38alpha or MAPKAPK2, had no significant effect on the chemotactic response to VEGF...
  42. ncbi A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
    J Han
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    Science 265:808-11. 1994
    ..A protein kinase, p38, that was tyrosine phosphorylated in response to LPS, was cloned...
  43. pmc Suppression of p38 MAPK and JNK via Akt-mediated inhibition of apoptosis signal-regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose-dependent insulinotropic polypeptide
    Scott B Widenmaier
    Department of Cellular and Physiological Sciences and the Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 284:30372-82. 2009
    ..Akt, and Akt siRNA, it was demonstrated that GIP promoted beta-cell survival via Akt-dependent suppression of p38 MAPK and JNK and that combined inhibition was sufficient to explain the entire pro-survival responses to GIP during ..
  44. ncbi IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells
    Huei Ting Yang
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Sir James Black Centre, Dow Street, Dundee, DD1 5EH, United Kingdom
    Cell Signal 20:375-80. 2008
    ..Specific inhibition of p38alpha MAP kinase or preventing the activation of ERK1/ERK2 partially reduced the production of these substances, while ..
  45. ncbi Role of p38 MAPK and RNA-dependent protein kinase (PKR) in hepatitis C virus core-dependent nuclear delocalization of cyclin B1
    Alessandra Spaziani
    Laboratory of Clinical Hepatology, Department of Internal Medicine, University of L Aquila, 67100 L Aquila, Italy
    J Biol Chem 281:10983-9. 2006
    ..On the other hand, the viral protein also increases the activity of the cyclin B1-CDK1 complex via the p38 MAPK and JNK pathways...
  46. pmc UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53
    Nadine Chouinard
    Unité de BioTechnologie, Centre de recherche de l Hôpital St François d Assise de Québec, 10 rue de l Espinay, Quebec G1L 3L5, Canada
    Biochem J 365:133-45. 2002
    ..We found that UVA, UVB or UVC induced a marked and persistent activation of p38, whereas c-Jun N-terminal kinase or extracellular signal-regulated kinase were less or not activated respectively...
  47. pmc Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
    M Deak
    MRC Protein Phosphorylation Unit, Departments of Biochemistry, Anatomy and Physiology, University of Dundee, Scotland
    EMBO J 17:4426-41. 1998
    ..MSK1 is activated in vitro by MAPK2/ERK2 or SAPK2/p38. Endogenous MSK1 is activated in 293 cells by either growth factor/phorbol ester stimulation, or by exposure to UV ..
  48. pmc REX-1 expression and p38 MAPK activation status can determine proliferation/differentiation fates in human mesenchymal stem cells
    Dilli Ram Bhandari
    Adult Stem Cell Research, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea
    PLoS ONE 5:e10493. 2010
    ..Human mesenchymal stem cells (hMSCs) isolated from young tissues and cancer cells express REX1...
  49. pmc Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis
    Gaetane Mace
    European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 24:3235-46. 2005
    ..of an activated mutant of Rab5 stimulated endocytosis of MOR ligand-independently in wild-type but not in p38alpha-/- cells...
  50. ncbi p38 MAPK in development and cancer
    Cynthia Bradham
    DCMB Group, Duke University, Durham, North Carolina, USA
    Cell Cycle 5:824-8. 2006
    b>p38 is a MAPK that has been shown to induce a wide variety of biological effects in cell culture in response to a wide range of stimuli...
  51. ncbi Interaction of p38 and Sp1 in a mechanical force-induced, beta 1 integrin-mediated transcriptional circuit that regulates the actin-binding protein filamin-A
    Mario D'Addario
    Canadian Institutes of Health Research Group in Matrix Dynamics, University of Toronto, Ontario, Canada
    J Biol Chem 277:47541-50. 2002
    ..This induction required actin filaments and selective activation of the p38 mitogen-activated protein kinase...
  52. pmc Vascular cell adhesion molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/MAPK/NF-kappaB: inhibitory role of curcumin
    David G Binion
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Physiol Gastrointest Liver Physiol 297:G259-68. 2009
    ..expression in HIMEC was suppressed by Akt small-interfering RNA, curcumin, and inhibitors of NF-kappaB (SN-50), p38 MAPK (SB-203580) and PI 3-kinase/Akt (LY-294002)...
  53. pmc HIV-1 activates macrophages independent of Toll-like receptors
    Joseph N Brown
    Division of Rheumatology, Immunology and Infectious Diseases, Department of Pathology, Immunology, and Laboratory Medicine, and Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA
    PLoS ONE 3:e3664. 2008
    ..Multiple genetic networks involved in regulating signal transduction cascades and immune responses in macrophages are coordinately modulated by HIV-1 infection...
  54. ncbi ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling
    Y Sano
    Laboratory of Molecular Genetics, Tsukuba Life Science Center, RIKEN, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    J Biol Chem 274:8949-57. 1999
    ..activity is enhanced after phosphorylation by stress-activated protein kinases such as c-Jun N-terminal kinase and p38. The binding between ATF-2 and Smad3/4 is mediated via the MH1 region of the Smad proteins and the basic leucine ..
  55. ncbi Morphine potentiates HIV-1 gp120-induced neuronal apoptosis
    Shuxian Hu
    Division of Infectious Diseases and International Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    J Infect Dis 191:886-9. 2005
    ..mechanism whereby morphine potentiates gp120(IIIB)-induced neuronal apoptosis appears to involve activation of the p38 mitogen-activated protein kinase intracellular signaling pathway and microglial cells dispersed within the neuronal/..
  56. ncbi PKD, PKD2, and p38 MAPK mediate Hsp27 serine-82 phosphorylation induced by neurotensin in pancreatic cancer PANC-1 cells
    Jingzhen Yuan
    Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine CURE Digestive Diseases Research Center and Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
    J Cell Biochem 103:648-62. 2008
    It is widely recognized that Hsp27 is a downstream substrate of the p38 MAPK cascade whereas the role of PKD family members in mediating receptor-stimulated Hsp27 Ser-82 phosphorylation has not been evaluated...
  57. doi HIV-1 Tat protein induces TNF-alpha and IL-10 production by human macrophages: differential implication of PKC-betaII and -delta isozymes and MAP kinases ERK1/2 and p38
    Kaoutar Leghmari
    Laboratoire d Immuno Virologie des Lentivirus des Primates, Université Paul Sabatier 118, Toulouse, France
    Cell Immunol 254:46-55. 2008
    ..However, p38 MAP kinase seems to be involved only in IL-10 and not TNF-alpha production.
  58. ncbi Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo
    K Deacon
    Department of Cell Physiology and Pharmacology, University of Leicester School of Medicine, P O Box 138, Medical Sciences Building, University Road, Leicester LE1 9HN, United Kingdom
    J Biol Chem 272:14489-96. 1997
    ..MKK3 specifically phosphorylates and activates p38, whereas MKK4 phosphorylates and activates both p38 and JNK...
  59. doi DJ-1 modulates the p38 mitogen-activated protein kinase pathway through physical interaction with apoptosis signal-regulating kinase 1
    Jung Soon Mo
    Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Yongbong Dong, Buk Ku, Gwangju 500 757, Republic of Korea
    J Cell Biochem 110:229-37. 2010
    ..of DJ-1 inhibited H(2)O(2)-induced activation of ASK1 as well as the activation of downstream kinases in the p38 mitogen-activated protein kinase (MAPK) signaling cascade...
  60. pmc MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
    J Raingeaud
    Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01605 USA
    Mol Cell Biol 16:1247-55. 1996
    ..The detection of p38 MAP kinase in the nucleus of activated cells suggests that p38 MAP kinase can mediate signaling to the nucleus...
  61. ncbi Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK
    Kazuyuki Kitatani
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 281:36793-802. 2006
    ..PMA treatment resulted in transient activation of mitogen-activated protein kinases (ERK1/2, JNK1/2, and p38) followed by dephosphorylation/inactivation...
  62. ncbi Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest
    K Takenaka
    Department of Biophysics, Graduate School of Science, Kyoto University, Kitashirakawa Oiwake, Sakyo ku, Kyoto 606 01, Japan
    Science 280:599-602. 1998
    ..classical MAPK (also called ERK), c-Jun amino-terminal or stress-activated protein kinase (JNK or SAPK), and p38. Although MAPK is essential for meiotic processes in Xenopus oocytes and the spindle assembly checkpoint in Xenopus ..
  63. doi HIV-1 Tat protein induces IL-10 production by an alternative TNF-alpha-independent pathway in monocytes: role of PKC-delta and p38 MAP kinase
    Kaoutar Leghmari
    Laboratoire d Immuno Virologie, EA 3038, Université Paul Sabatier 118, route de Narbonne 4R3, 31062 Toulouse, Cedex, France
    Cell Immunol 253:45-53. 2008
    ..induce IL-10 production, we evaluated the link between Tat, TNF-alpha and IL-10 and the implication of PKC and p38 MAP kinase pathways...
  64. ncbi Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
    J Raingeaud
    Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605, USA
    J Biol Chem 270:7420-6. 1995
    ..Immunofluorescence microscopy demonstrated that p38 MAP kinase is present in both the nucleus and cytoplasm of activated cells...
  65. ncbi The Epstein-Barr virus oncoprotein latent membrane protein 1 induces expression of the chemokine IP-10: importance of mRNA half-life regulation
    Martina Vockerodt
    Zentrum Kinderheilkunde und Jugendmedizin, Abteilung Pädiatrie I, Georg August Universitat, Gottingen, Germany
    Int J Cancer 114:598-605. 2005
    ..IP-10 induction is inhibited by blockade of p38/SAPK2 with SB 202190, which results in decreased IP-10 mRNA half-life without affecting IP-10 promoter activity...
  66. ncbi Signal transducer and activator of transcription factor 1 mediates apoptosis induced by hepatitis C virus and HIV envelope proteins in hepatocytes
    Anuradha Balasubramanian
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA
    J Infect Dis 194:670-81. 2006
    ..Moreover, inhibitor studies indicated that Lyn kinase, p38 mitogen-activated protein kinase, and protein kinase C delta might be involved in STAT1 phosphorylation...
  67. ncbi Kiss-1 suppresses MMP-9 expression by activating p38 MAP kinase in human stomach cancer
    Kyung Hee Lee
    Department of Hematology Oncology, College of Medicine, Yeungnam University, Daegu, Korea
    Oncol Res 18:107-16. 2009
    ..Downregulation of Kiss-1 using Kiss-1 shRNA also increased in vitro cell invasion. In conclusion, Kiss-1 suppresses MMP-9 expression by activating the p38 MAP kinase signaling pathway.
  68. doi A p38(MAPK)/HIF-1 pathway initiated by UVB irradiation is required to induce Noxa and apoptosis of human keratinocytes
    Kris Nys
    Cell Death Research and Therapy Laboratory, Department of Molecular Cell Biology, Catholic University of Leuven, Leuven, Belgium
    J Invest Dermatol 130:2269-76. 2010
    ..Previously, we reported that in UVB-irradiated keratinocytes, p38(MAPK) instigates Bcl-2-associated X protein (Bax) activation and mitochondrial apoptosis...
  69. doi Nox2-based NADPH oxidase mediates HIV-1 Tat-induced up-regulation of VCAM-1/ICAM-1 and subsequent monocyte adhesion in human astrocytes
    Ha Yong Song
    Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chunchon 200 702, Republic of Korea
    Free Radic Biol Med 50:576-84. 2011
    ..siRNA decreased HIV-1 Tat-induced NF-κB activation as well as activation of MAP kinases including ERK, JNK, and p38. These data indicate that Nox2-based NADPH oxidase is responsible for HIV-1 Tat-induced generation of ROS and plays ..
  70. doi Caveolin-1 acts as a tumor suppressor by down-regulating epidermal growth factor receptor-mitogen-activated protein kinase signaling pathway in pancreatic carcinoma cell lines
    Fei Han
    Department of Pathology, Fudan University, Shanghai, China
    Pancreas 38:766-74. 2009
    ..To investigate the effect of caveolin-1 (cav1) in pancreatic carcinoma panc1 cell growth in vitro and in vivo...
  71. ncbi Interleukin-8 induces the endothelial cell migration through the Rac 1/RhoA-p38MAPK pathway
    Y Lai
    Institute of Biomedical Engineering, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China
    Eur Rev Med Pharmacol Sci 16:630-8. 2012
    ..The objective of this study was to investigate the molecular mechanism of IL-8 induced endothelial cell migration in vitro...
  72. ncbi Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2
    V Sanz
    Unidad de Biología Molecular del Cáncer, Departamento de Biologia Molecular, Universidad de Cantabria, Santander, Spain
    FEBS Lett 474:169-74. 2000
    The p38 family of mitogen-activated protein kinases is composed of several isoforms. Mxi2 is a splicing variant of p38alpha that harbors a unique carboxy-terminus...
  73. pmc T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascade
    Vinod S Ramgolam
    Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, Departments of Medicine Cardiovascular Medicine and Immunobiology, Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 5:e14450. 2010
    ..However, little is known regarding integrin-induced signaling cascades that affect mRNA catabolism. This study examines the role of the GTPases, Rac 1 and Rac 2, and their downstream effectors, in the LFA-1-induced effects on mRNA...
  74. doi p38 MAP kinase controls EGF receptor downregulation via phosphorylation at Ser1046/1047
    Seiji Adachi
    Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, Japan
    Cancer Lett 277:108-13. 2009
    ..Anisomycin, a potent kinase activator, induced the activation of both p38 mitogen-activated protein kinase (MAPK) and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), but ..
  75. ncbi Shock waves increase T-cell proliferation or IL-2 expression by activating p38 MAP kinase
    Tie Cheng Yu
    Department of Orthopedics, The First Teaching Hospital of Jilin University, Changchun 130021, China
    Acta Biochim Biophys Sin (Shanghai) 36:741-8. 2004
    ..organelles, might augment T-cell proliferation as well as IL-2 expression, and if mitogen activated protein kinase p38 (p38 MAPK) might be an underlying mechanism through which the LDSWs enhanced T-cell function...
  76. pmc Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase
    Thomais Markou
    Laboratory of Animal Physiology, Department of Zoology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
    Biochem J 365:757-63. 2002
    ..Maximal activation of MSK1 in adult cardiomyocytes temporally coincided with maximal p38 MAPK activation while activation of the extracellular-signal-regulated kinase (ERK) cascade was more rapid...
  77. pmc Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions
    T Tanoue
    Department of Biophysics, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    EMBO J 20:466-79. 2001
    ..However, the CD domain alone does not determine the docking specificity. Here we have identified a novel site on p38 and ERK2 MAPKs that regulates the docking specificity towards MAPKAPKs...
  78. doi ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts
    Indira Prasadam
    Queensland University of Technology, Brisbane, Queensland, Australia
    Arthritis Rheum 62:1349-60. 2010
    ..The aim of this study was to investigate the in vitro effects of OA SBOs on the phenotypical changes in normal ACCs and to unveil the potential involvement of MAPK signaling pathways during this process...
  79. ncbi p38 MAPK and ERK activation by 9-cis-retinoic acid induces chemokine receptors CCR1 and CCR2 expression in human monocytic THP-1 cells
    Jesang Ko
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    Exp Mol Med 39:129-38. 2007
    ..up-regulation of CCR1 and CCR2 in 9CRA-stimulated cells were weakly blocked by the pretreatment of SB202190, a p38 MAPK inhibitor, and PD98059, an upstream ERK inhibitor...
  80. doi Toll-like receptor 4 regulates heme oxygenase-1 expression after hemorrhagic shock induced acute lung injury in mice: requirement of p38 mitogen-activated protein kinase activation
    Chang Chen
    Department of Anesthesiology, Zhongnan Hospital, Medical College of Wuhan University, Wuhan, Hubei, People s Republic of China
    Shock 31:486-92. 2009
    ..Arterial blood gases; expressions of TLR-4, heme oxygenase 1 (HO-1), and p38 mitogen-activated protein kinase (p38MAPK); myeloperoxidase activity; lung wet/dry ratios; and IL-10 levels in lung ..
  81. ncbi Cell growth of ovarian cancer cells is stimulated by xenoestrogens through an estrogen-dependent pathway, but their stimulation of cell growth appears not to be involved in the activation of the mitogen-activated protein kinases ERK-1 and p38
    Se Hyung Park
    Department of Obstetrics and Gynecology, British Columbia Women s Hospital, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    J Reprod Dev 55:23-9. 2009
    ..BPA rapidly induced activation of extracellular signal-regulated kinase (ERK) 1/2 and p38 MAPK at 15 min, but the effect of BPA (10 microM) on stimulation of cell growth was not blocked by pretreatment ..
  82. pmc Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor
    Pallavi S Peter
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Clin Invest 117:1335-43. 2007
    We examined the role of p38alpha MAPK in mediating cardiomyopathy in mice overexpressing beta(1)-adrenergic receptor (beta(1)-AR) or beta(2)-AR by mating them with dominant-negative p38alpha (DNp38alpha) MAPK mice...
  83. pmc Involvement of connexin 43 in angiotensin II-induced migration and proliferation of saphenous vein smooth muscle cells via the MAPK-AP-1 signaling pathway
    Guanghong Jia
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    J Mol Cell Cardiol 44:882-90. 2008
    ..The effect of angiotensin II was blocked by siRNA of ERK 1/2, p38 MAPK and JNK, respectively. Overexpression of Cx43 markedly increased the proliferation of saphenous vein SMCs...
  84. pmc A novel protein kinase A-independent, beta-arrestin-1-dependent signaling pathway for p38 mitogen-activated protein kinase activation by beta2-adrenergic receptors
    Kaizheng Gong
    Institute of Vascular Medicine, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, China
    J Biol Chem 283:29028-36. 2008
    A growing body of evidence has demonstrated that p38 mitogen-activated protein kinase (MAPK) has a crucial role in various physiological and pathological processes mediated by beta(2)-adrenergic receptors (beta(2)-ARs)...
  85. pmc STAT3, p38 MAPK, and NF-kappaB drive unopposed monocyte-dependent fibroblast MMP-1 secretion in tuberculosis
    Cecilia M O'Kane
    Department of Infectious Diseases and Immunity, Hammersmith Campus, Imperial College London, London, United Kingdom
    Am J Respir Cell Mol Biol 43:465-74. 2010
    ..MMP-1 up-regulation and TIMP-1 down-regulation were p38 (but not extracellular signal-regulated kinase or c-Jun N-terminal kinase) mitogen-activated protein kinase-..
  86. pmc Differential induction of interleukin-10 in monocytes by HIV-1 clade B and clade C Tat proteins
    Justine K Wong
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:18319-25. 2010
    ..Moreover, we show that p38alpha/p38beta and phosphoinositide 3-kinase are crucial to Tat-induced IL-10 production...
  87. pmc Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway
    Jennifer A Markovics
    Department of Pathology, Pulmonary Division, School of Medicine, University of California, San Francisco, California 94110, USA
    J Biol Chem 285:24695-706. 2010
    ..expression and that Sp1, Sp3, and several AP-1 transcription factors form a complex that binds to these sites in a p38-dependent manner...
  88. doi Reactive oxygen species-activated p38/ERK 1/2 MAPK signaling pathway in the Mycobacterium bovis bacillus Calmette Guérin (BCG)-induced CCL2 secretion in human monocytic cell line THP-1
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, IPN, Mexico, D F, Mexico
    Arch Med Res 41:579-85. 2010
    ....
  89. doi Tumor necrosis factor-alpha upregulates 11beta-hydroxysteroid dehydrogenase type 1 expression by CCAAT/enhancer binding protein-beta in HepG2 cells
    Irena D Ignatova
    Depts of Nephrology and Hypertension and Clinical Research, Freiburgstrasse 15, Univ Hospital, Berne, CH 3010 Berne, Switzerland
    Am J Physiol Endocrinol Metab 296:E367-77. 2009
    ..We found that TNF-alpha acts via p38 MAPK pathway...
  90. ncbi Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells
    Hye Jung Kang
    College of Pharmacy, Duksung Women s University, 4129 Ssangmun dong, Tobong ku, Seoul 132 714, Korea
    Int J Cancer 103:475-82. 2003
    ..In H-ras MCF10A cells, capsaicin treatment markedly activated c-Jun N-terminal protein kinase (JNK)-1 and p38 matigen-activated protein kinase (MAPK) while it deactivated extracellular signal-regulated protein kinases (ERKs)...
  91. pmc Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines
    Rosa A Cardone
    Department of General and Environmental Physiology, University of Bari, 70126 Bari, Italy
    Mol Biol Cell 16:3117-27. 2005
    ....
  92. ncbi Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1
    D N Slack
    Imperial Cancer Research Fund Molecular Pharmacology Unit, Biomedical Research Centre, Level 5, Ninewells Hospital, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 276:16491-500. 2001
    ..that MKP-1 is able to interact selectively with the extracellular signal-regulated kinase 1/2 (ERK1/2), p38alpha, and c-Jun NH(2)-terminal kinase (JNK) MAP kinase isoforms...
  93. ncbi Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type 1 responses
    Hermann R Bohnenkamp
    Cancer Research UK, Breast Cancer Biology Group, Thomas Guy House, 3rd Floor, Guy s Hospital, London SE1 9RT, UK
    Cell Immunol 247:72-84. 2007
    ..activation of nuclear factor-kappaB (NF-kappaB) and mitogen activated protein kinases (MAPK) such as SAPK/JNK and p38 MAPK and the interferon (IFN) dependent pathway that signals via TRIF and results in the production of IFN-alpha/..
  94. pmc Hierarchical phosphorylation of the translation inhibitor 4E-BP1
    A C Gingras
    Department of Biochemistry and McGill Cancer Centre, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Genes Dev 15:2852-64. 2001
    ..Finally, we show that phosphorylation of Ser 65 and Thr 70 alone is insufficient to block binding to eIF4E, indicating that a combination of phosphorylation events is necessary to dissociate 4E-BP1 from eIF4E...
  95. ncbi Hypoxia activates beta(1)-integrin via ERK 1/2 and p38 MAP kinase in human vascular smooth muscle cells
    Florian Blaschke
    Deutsches Herzzentrum Berlin, Department of Cardiology, Augustenburger Platz 1, 13353 Berlin, Germany
    Biochem Biophys Res Commun 296:890-6. 2002
    ..of the pharmacological ERK 1/2 mitogen-activated protein kinase (MAPK) pathway inhibitor PD98059 (30 microM) or the p38 MAPK inhibitor SB203580 (1 microM)...
  96. ncbi p38 mitogen-activated protein kinase stimulates estrogen-mediated transcription and proliferation through the phosphorylation and potentiation of the p160 coactivator glucocorticoid receptor-interacting protein 1
    Daniel E Frigo
    Molecular and Cellular Biology Program, Center for Bioenvironmental Research, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Mol Endocrinol 20:971-83. 2006
    ..Here, we demonstrate that the p38 MAPK stimulates both ERalpha- and ERbeta-mediated transcription in MCF-7 breast carcinoma, Ishikawa endometrial ..
  97. ncbi Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light
    Tamara Tanos
    Laboratorio de Fisiologia y Biologia Molecular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIBYNE CONICET, 1428 Buenos Aires, Argentina
    J Biol Chem 280:18842-52. 2005
    ..Using a specific pharmacological inhibitor for p38alpha and -beta, we found that most likely these two isoforms mediate UV-induced c-Fos phosphorylation in vivo...
  98. ncbi A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
    L Tong
    Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut 06877, USA
    Nat Struct Biol 4:311-6. 1997
    The crystal structure of human p38 mitogen-activated protein (MAP) kinase in complex with a potent and highly specific pyridinyl-imidazole inhibitor has been determined at 2.0 A resolution...
  99. ncbi Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells
    Richard M Ogborne
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, CB1 9NL, UK
    Arterioscler Thromb Vasc Biol 25:2100-5. 2005
    ..This study examined the effects of ALA on HO-1 expression in human monocytic cells...
  100. ncbi Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
    J Han
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 386:296-9. 1997
    ..In mammalian cells the MAPK p38 is thought to play an important role in the regulation of cellular responses during infection through its effects ..
  101. ncbi The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase
    S Katz
    Department of Molecular Genetics and the Rappaport Family Institute for Research in the Medical Sciences and the B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O Box 9649, Bat Galim, 31096, Haifa, Israel
    FEBS Lett 506:196-200. 2001
    ..Our data indicate that JDP2 is a bona fide substrate for the c-Jun N-terminal kinase. The precise role of JDP2 phosphorylation on its function is not yet known...

Research Grants72

  1. Regulation of airway epithelial repair
    Steven White; Fiscal Year: 2006
    ..cytokines activate specific signaling pathways that activate the mitogen-activated protein kinases (MAPKs), such as p38 MARK and JNK, that in turn initiate early steps in the migration of airway epithelial cells to cover damaged ..
  2. Regulation of airway epithelial repair
    Steven R White; Fiscal Year: 2010
    ..cytokines activate specific signaling pathways that activate the mitogen-activated protein kinases (MAPKs), such as p38 MARK and JNK, that in turn initiate early steps in the migration of airway epithelial cells to cover damaged ..
  3. Regulation of airway epithelial repair
    Steven White; Fiscal Year: 2007
    ..cytokines activate specific signaling pathways that activate the mitogen-activated protein kinases (MAPKs), such as p38 MARK and JNK, that in turn initiate early steps in the migration of airway epithelial cells to cover damaged ..
  4. Role of Signal Transduction in Burn and Wound Healing
    Saman Arbabi; Fiscal Year: 2006
    ..We have focused on p38 and ERK, two important MAPK families, regulating inflammatory response and apoptosis...
  5. Modulation of CNS Proinflammatory Cytokine Production
    Linda J Van Eldik; Fiscal Year: 2010
    ..proinflammatory cytokine overproduction and subsequent neuronal/synaptic damage, and that suppression of p38 MAPK signaling in the microglia and/or neuron can lead to selective, beneficial outcomes...
  6. Mechanisms For p38 MAP Kinase DependentT Gene Induction
    Betty Pace; Fiscal Year: 2004
    ..on this deduction, we initiated studies with two HDAIs sodium butyrate and trichosatin A and found both to activate p38 mitogen activating protein kinase (p38 MAPK) and activating transcription factor 2 (ATF-2)...
  7. Reactive Oxygen Species in Coronary Collateral Growth
    William M Chilian; Fiscal Year: 2010
    ..Aim 4. Determine the cell type where expression of a constitutively active p38 MAP kinase will restore collateral growth in the JCR rat...
  8. Reactive Oxygen Species in Coronary Collateral Growth
    WILLIAM CHILIAN; Fiscal Year: 2009
    ..Aim 4. Determine the cell type where expression of a constitutively active p38 MAP kinase will restore collateral growth in the JCR rat...
  9. Transcription & Function of Adipocyte Beta3AR in Obesity
    Sheila Collins; Fiscal Year: 2006
    ..Aims proposed: (1) to characterize the signal transduction pathway linking the betaARs in adipocytes to the p38 MAP kinase; to test the hypothesis that Rac1/Cdc42 and the MLKs are activated by PKA and, in turn, directly activate MKK3/..
  10. p38 MAP kinase in early thymocyte development
    Mercedes Rincon; Fiscal Year: 2010
    The p38 MAP kinase (MAPK) pathway is activated in response to stress stimuli (e.g...
  11. p38 MAP kinase in early thymocyte development
    Mercedes Rincon; Fiscal Year: 2009
    The p38 MAP kinase (MAPK) pathway is activated in response to stress stimuli (e.g...
  12. P38 MAP KINASE SIGNALING IN SKIN
    Tatiana Efimova; Fiscal Year: 2010
    ..The p38 MAPK family members function in a cell type-specific and cell context-specific manner to regulate cell ..
  13. Role of p38 MAPK in IL-4-induced IL-6 expression in vascular endothelium
    Yongwoo Lee; Fiscal Year: 2007
    ..the proposed project, we hypothesize that IL-4 may induce inflammatory pathways in vascular endothelium through the p38 MAPK-mediated up-regulation of IL-6 expression...
  14. MECHANISMS OF THROMBIN INDUCED TOLERANCE TO BRAIN INJURY
    Guohua Xi; Fiscal Year: 2002
    ..may be associated with heat shock protein (HSP) 27 and/or colligin induction; 3) TPC activates p38 mitogen activated protein kinase (p38 MAP kinase) and extracellular signal regulated kinase (ERK) p44/42 MAP kinase; 4) TPC-induced ..
  15. Macrophage Foam Cells, Cathepsins and Cholesterol Efflux
    ALAN RICHARD TALL; Fiscal Year: 2010
    ..by binding of RANK ligand to RANK (Receptor Activator of NFkB) on macrophages and requiring activation of p38 MAP kinase. In Aim1 we will further define the relationship between different endosomal cholesterol pools, induction of ..
  16. Macrophage Foam Cells, Cathepsins and Cholesterol Efflux
    Alan Tall; Fiscal Year: 2007
    ..by binding of RANK ligand to RANK (Receptor Activator of NFkB) on macrophages and requiring activation of p38 MAP kinase. In Aim1 we will further define the relationship between different endosomal cholesterol pools, induction of ..
  17. ERYTHROPOIETIN AND THE REGULATION OF ERYTHROPOIESIS
    Sanford Krantz; Fiscal Year: 2003
    ..In addition, withdrawal of EPO activates the Jun N-terminal kinases (JNKs) and p38 MAP kinase which also produce apoptosis...
  18. Development of Novel p38 MAPK Inhibitors as Therapeutics for CNS Disorders
    DANIEL MARTIN WATTERSON; Fiscal Year: 2010
    ..This proposal tests the hypothesis that novel p38 MAPK inhibitors that are orally bioavailable, have good brain uptake, and are non-toxic can be developed into a new ..
  19. Role of p38 MAPK in HSC Self-Renewal and Radiation-Induced Bone Marrow Injury
    Daohong Zhou; Fiscal Year: 2010
    ..Recent studies from our laboratory and others suggest that p38 0-activated protein kinase (p38) is a negative regulator of HSC self- renewal and its activation may mediate IR-..
  20. Role of p38 MAPK in HSC Self-Renewal and Radiation-Induced Bone Marrow Injury
    Daohong Zhou; Fiscal Year: 2009
    ..Recent studies from our laboratory and others suggest that p38 0-activated protein kinase (p38) is a negative regulator of HSC self- renewal and its activation may mediate IR-..
  21. Development of Novel p38 MAPK Inhibitors as Therapeutics for CNS Disorders
    D Watterson; Fiscal Year: 2009
    ..This proposal tests the hypothesis that novel p38 MAPK inhibitors that are orally bioavailable, have good brain uptake, and are non-toxic can be developed into a new ..
  22. Urolithiasis: Oxalate Interactions with the Renal Cells
    Hari Koul; Fiscal Year: 2009
    ..During the five year funding period, we demonstrated that oxalate and COM-crystals activate p38 MAP kinase pathway and NF-kB transcription factor...
  23. Urolithiasis: Oxalate Interactions with the Renal Cells
    Hari K Koul; Fiscal Year: 2010
    ..During the five year funding period, we demonstrated that oxalate and COM-crystals activate p38 MAP kinase pathway and NF-kB transcription factor...
  24. Urolithiasis: Oxalate Interactions with the Renal Cells
    Hari K Koul; Fiscal Year: 2010
    ..During the five year funding period, we demonstrated that oxalate and COM-crystals activate p38 MAP kinase pathway and NF-kB transcription factor...
  25. p38 MAP Kinase and Akt Interaction in HUVEC
    Shehla Pervin; Fiscal Year: 2007
    ..umbilical vein endothelial cells (HUVEC) to stress, with emphasis on cross talk between PI-3 Kinase/Akt and p38 MAP Kinase pathways. It is found that male fetus has greater mortality rate than female...
  26. Novel Bioactive Lipid Receptors in Growth Regulation
    Yan Xu; Fiscal Year: 2005
    ..We hypothesize that p38 MAP kinase plays a critical role in mediating the growth inhibitory effect of SPC...
  27. p38 MAPK in Ras-induced Senescence and Transformation
    Peiqing Sun; Fiscal Year: 2010
    The p38 MAPK pathway was initially identified as a mediator of inflammatory and stress responses. We and others have shown that this pathway also participates in tumor suppressing cellular responses such as oncogene-induced senescence...
  28. Regulation of Neuronal Survival by the Rit GTPase
    DOUGLAS ALLEN ANDRES; Fiscal Year: 2010
    ..and neurotrophin-initiated signals, to activate a distinct pro-survival signaling cascade that relies upon p38 MAP kinase signaling...
  29. Epilepsy and dendritic excitability
    Nicholas P Poolos; Fiscal Year: 2010
    ..A novel modulator of HCN channel gating, p38 mitogen- activated kinase (p38 MAPK), was characterized as well, with inhibition of p38 MAPK causing downregulation ..
  30. The Role of Xanthine Oxidoreductase in Ventilator-Associated Lung Injury
    Paul M Hassoun; Fiscal Year: 2010
    ..and pharmacological inhibitors to test our hypotheses that the enzyme xanthine oxidoreductase (XOR) and the p38 MAP kinase signaling pathway play crucial roles in the pathogenesis of VALI, and anticipate that the studies proposed ..
  31. REGULATION OF PHOSPHOLIPASE A2 IN HUMAN AMNION
    Leslie Myatt; Fiscal Year: 2003
    ..We have preliminary evidence for involvement of p38 MAP kinase in this pathway...