p300

Summary

Gene Symbol: p300
Description: E1A binding protein p300
Alias: KAT3B, RSTS2, p300, E1A-associated protein p300, E1A-binding protein, 300kD, p300 HAT
Species: human

Top Publications

  1. pmc Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
    Weibo Luo
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 145:732-44. 2011
  2. pmc CBP/p300-mediated acetylation of histone H3 on lysine 56
    Chandrima Das
    Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, PO Box 6511, Aurora Colorado 80045, USA
    Nature 459:113-7. 2009
  3. ncbi A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
    X J Yang
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2753, USA
    Nature 382:319-24. 1996
  4. pmc DNA damage activates p53 through a phosphorylation-acetylation cascade
    K Sakaguchi
    Laboratory of Cell Biology, National Cancer Institute NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 12:2831-41. 1998
  5. ncbi Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor
    R Eckner
    Dana Farber Cancer Institute, Boston, Massachusetts 02115
    Genes Dev 8:869-84. 1994
  6. pmc Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1
    Maimon E Hubbi
    Graduate Training Program in Cellular and Molecular Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 287:6139-49. 2012
  7. pmc The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling
    Rui Chen
    Department of Medicine, Veterans Affairs North Texas Health Care System, Dallas, TX 75216, USA
    J Biol Chem 287:30800-11. 2012
  8. doi Interplay of acetyltransferase EP300 and the proteasome system in regulating heat shock transcription factor 1
    Swasti Raychaudhuri
    Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Cell 156:975-85. 2014
  9. pmc Zinc-induced formation of a coactivator complex containing the zinc-sensing transcription factor MTF-1, p300/CBP, and Sp1
    Yong Li
    Department of Biochemistry and Molecular Biology, Mail Stop 3030, University of Kansas Medical Center, 39th and Rainbow Blvd, Kansas City, KS 66160 7421, USA
    Mol Cell Biol 28:4275-84. 2008
  10. ncbi The transcriptional coactivators p300 and CBP are histone acetyltransferases
    V V Ogryzko
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2753, USA
    Cell 87:953-9. 1996

Detail Information

Publications352 found, 100 shown here

  1. pmc Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
    Weibo Luo
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 145:732-44. 2011
    ..directly with the HIF-1α subunit and promotes transactivation of HIF-1 target genes by enhancing HIF-1 binding and p300 recruitment to hypoxia response elements, whereas PKM1 fails to regulate HIF-1 activity...
  2. pmc CBP/p300-mediated acetylation of histone H3 on lysine 56
    Chandrima Das
    Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, PO Box 6511, Aurora Colorado 80045, USA
    Nature 459:113-7. 2009
    ..Here we demonstrate that the histone acetyl transferase CBP (also known as Nejire) in flies and CBP and p300 (Ep300) in humans acetylate H3K56, whereas Drosophila Sir2 and human SIRT1 and SIRT2 deacetylate H3K56ac...
  3. ncbi A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
    X J Yang
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2753, USA
    Nature 382:319-24. 1996
    The adenoviral oncoprotein E1A induces progression through the cell cycle by binding to the products of the p300/CBP and retinoblastoma gene families...
  4. pmc DNA damage activates p53 through a phosphorylation-acetylation cascade
    K Sakaguchi
    Laboratory of Cell Biology, National Cancer Institute NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 12:2831-41. 1998
    ..p53 is acetylated in vitro at separate sites by two different histone acetyltransferases (HATs), the coactivators p300 and PCAF...
  5. ncbi Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor
    R Eckner
    Dana Farber Cancer Institute, Boston, Massachusetts 02115
    Genes Dev 8:869-84. 1994
    ..Among these are the retinoblastoma protein, p107, p130, and p300. We have isolated a cDNA encoding full-length human p300 and mapped the chromosomal location of the gene to ..
  6. pmc Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1
    Maimon E Hubbi
    Graduate Training Program in Cellular and Molecular Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 287:6139-49. 2012
    ..FHL2 directly interacts with HIF-1α to repress transcriptional activity. FHL1 binds to the p300/CBP co-activators and disrupts binding with HIF-1α...
  7. pmc The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling
    Rui Chen
    Department of Medicine, Veterans Affairs North Texas Health Care System, Dallas, TX 75216, USA
    J Biol Chem 287:30800-11. 2012
    ..now demonstrate that the lysine acetyltransferases cAMP-response element-binding protein-binding protein (CBP) and p300 are required for efficient Epo induction during hypoxia...
  8. doi Interplay of acetyltransferase EP300 and the proteasome system in regulating heat shock transcription factor 1
    Swasti Raychaudhuri
    Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Cell 156:975-85. 2014
    ..Finally, the nuclear proteasome system functions in attenuating the stress response by degrading activated HSF1 in a manner linked with the clearance of misfolded proteins. ..
  9. pmc Zinc-induced formation of a coactivator complex containing the zinc-sensing transcription factor MTF-1, p300/CBP, and Sp1
    Yong Li
    Department of Biochemistry and Molecular Biology, Mail Stop 3030, University of Kansas Medical Center, 39th and Rainbow Blvd, Kansas City, KS 66160 7421, USA
    Mol Cell Biol 28:4275-84. 2008
    ..to zinc resulted in the rapid formation of a multiprotein complex containing MTF-1, the histone acetyltransferase p300/CBP, and the transcription factor Sp1...
  10. ncbi The transcriptional coactivators p300 and CBP are histone acetyltransferases
    V V Ogryzko
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2753, USA
    Cell 87:953-9. 1996
    b>p300/CBP is a transcriptional adaptor that integrates signals from many sequence-specific activators via direct interactions. Various cellular and viral factors target p300/CBP to modulate transcription and/or cell cycle progression...
  11. pmc c-Myc-induced aberrant DNA synthesis and activation of DNA damage response in p300 knockdown cells
    Natesan Sankar
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 284:15193-205. 2009
    We previously showed that in quiescent cells, p300/CBP (CREB-binding protein)family coactivators repress c-myc and prevent premature induction of DNA synthesis...
  12. pmc Molecular characterization of HTLV-1 Tax interaction with the KIX domain of CBP/p300
    Julita A Ramírez
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523 1870, USA
    J Mol Biol 372:958-69. 2007
    ..to the HTLV-1 promoter facilitate viral transcription via the recruitment of the large cellular coactivators CBP/p300. While the interaction between the phosphorylated kinase inducible domain (pKID) of pCREB and the KIX domain of CBP/..
  13. ncbi The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism
    Yan Shan Dai
    Department of Pediatrics, University of Cincinnati, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 277:24390-8. 2002
    ..This transcriptional synergy observed between GATA4 and dHAND was associated with p300 recruitment, but not with alterations in DNA binding activity of either factor...
  14. pmc Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1
    H M Sheppard
    Department of Biochemistry, University of Leicester, Leicester, LE1 7RH, United Kingdom
    Mol Cell Biol 21:39-50. 2001
    ..receptor coactivator 1 (SRC1) and its homologues and the general coactivators CREB binding protein (CBP) and p300. SRC1 contains an activation domain (AD1) which functions via recruitment of CBP and and p300...
  15. pmc CBP/p300 interact with and function as transcriptional coactivators of BRCA1
    G M Pao
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 97:1020-5. 2000
    ..We now describe that BRCA1-mediated transactivation is enhanced by p300/CBP (CREB binding protein) and that this effect was suppressed by the adenovirus E1A oncoprotein...
  16. pmc Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1
    S Sengupta
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 1079, USA
    Oncogene 30:482-93. 2011
    ..APE1 is stably associated with the basic transcription factor RNA polymerase II (RNA pol II) and the coactivator p300 on the endogenous MDR1 promoter...
  17. pmc Interaction and functional collaboration of p300 and C/EBPbeta
    S Mink
    Hans Spemann Laboratory, Max Planck Institute for Immunobiology, Freiburg, Germany
    Mol Cell Biol 17:6609-17. 1997
    Transcriptional coactivators such as p300 and CREB-binding protein (CBP) function as important elements in the transcription factor network, linking individual transactivators via protein-protein interactions to the basal transcriptional ..
  18. ncbi Regulation of the p300 HAT domain via a novel activation loop
    Paul R Thompson
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Struct Mol Biol 11:308-15. 2004
    ..However, the molecular events that regulate p300 HAT activity are poorly understood...
  19. ncbi p300 mediates androgen-independent transactivation of the androgen receptor by interleukin 6
    Jose D Debes
    Departments of Urology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Cancer Res 62:5632-6. 2002
    ..The coactivator p300 has been shown to interact with the AR during its androgen-dependent transactivation...
  20. pmc p300-mediated acetylation of histone H3 lysine 56 functions in DNA damage response in mammals
    Rahul K Vempati
    Department of Biology, Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046, India
    J Biol Chem 285:28553-64. 2010
    ..We also demonstrate that the histone acetyltransferase p300 acetylates H3K56 in vitro and in vivo, whereas hSIRT2 and hSIRT3 deacetylate H3K56ac in vivo...
  21. ncbi Activator-dependent transcription from chromatin in vitro involving targeted histone acetylation by p300
    T K Kundu
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021, USA
    Mol Cell 6:551-61. 2000
    The transcriptional coactivator p300 shows physical and functional interactions with a diverse group of activators and contains an intrinsic acetyltransferase activity whose exact coactivator functions in the acetylation of nucleosomal ..
  22. ncbi Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)
    Ralf Janknecht
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Oncogene 22:746-55. 2003
    ..Consistently, MSK1 interacts with two homologous coactivators of ER81, CBP and p300, and stimulates the transactivation domains of CBP...
  23. pmc Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300
    Jorge L Ruas
    Department of Cell and Molecular Biology, Karolinska Institutet, Von Eulers vag 3, S 171 77 Stockholm, Sweden
    J Biol Chem 285:2601-9. 2010
    ..domain of HIF-1 alpha has been shown to interact with cysteine/histidine-rich region 1 (CH1) of the coactivator CBP/p300 in a hypoxia-dependent manner...
  24. pmc Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination
    Young Ho Lee
    Department of Pathology, University of Southern California, 2011 Zonal Avenue, HMR 301, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 102:3611-6. 2005
    ..retinoid receptors], the histone acetyltransferases cAMP response element binding protein binding protein (CBP) and p300 and the histone methyltransferase coactivator-associated arginine methyltransferase (CARM1) depends on the ..
  25. ncbi DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes
    Antonio Costanzo
    Laboratory of Gene Expression, Fondazione Andrea Cesalpino, University of Rome La Sapienza, 00161, Rome, Italy
    Mol Cell 9:175-86. 2002
    ..Here, we show that DNA damage induces the acetylation of p73 by the acetyltransferase p300. Inhibiting the enzymatic activity of p300 hampers apoptosis in a p53(-/-) background...
  26. pmc Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling
    J J Zhang
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 93:15092-6. 1996
    ..We show here that Stat1 can directly interact with the CREB-binding protein (CBP)/p300 family of transcriptional coactivators...
  27. pmc A transcription cofactor required for the heat-shock response
    Danmei Xu
    Laboratory of Cancer Biology, Medical Sciences Division, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
    EMBO Rep 9:662-9. 2008
    The Stress-responsive activator of p300 (Strap) is a transcription cofactor that has an important role in the control of DNA damage response through its ability to regulate p53 activity...
  28. ncbi Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP
    J R Lundblad
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    Nature 374:85-8. 1995
    ..in CREB binding and transcriptional activation are highly related to the adenoviral E1A-associated cellular protein p300 (refs 2, 3), and to two hypothetical proteins from Caenorhabditis elegans, R10E11.1 and K03H1...
  29. ncbi The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1
    Haihong Zhong
    Immunobiology Section and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Cell 9:625-36. 2002
    ..Our results demonstrate that phosphorylation of p65 determines whether it associates with either CBP or HDAC-1, ensuring that only p65 entering the nucleus from cytoplasmic NF-kappa B:Ikappa B complexes can activate transcription...
  30. pmc Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion
    Yonghua Yang
    Medical College of Georgia Cancer Center, Augusta, Georgia, USA
    Cancer Res 68:4833-42. 2008
    ..Thus, reversible hyperacetylation modulates the intracellular and extracellular chaperone function of hsp90, and targeting extracellular hyperacetylated hsp90alpha may undermine tumor invasion and metastasis...
  31. ncbi Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
    W Gu
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
    Cell 90:595-606. 1997
    ..Remarkably, the site of p53 that is acetylated by its coactivator, p300, resides in a C-terminal domain known to be critical for the regulation of p53 DNA binding...
  32. pmc p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
    L Liu
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 19:1202-9. 1999
    ..studies suggest that full transcriptional activity of p53 requires the coactivators CREB binding protein (CBP)/p300 and PCAF...
  33. ncbi Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
    David Lando
    Department of Molecular Biosciences Biochemistry, Adelaide University, SA 5005, Australia
    Science 295:858-61. 2002
    ..dioxygenases prevented hydroxylation of the Asn, thus allowing the CAD to interact with the p300 transcription coactivator...
  34. ncbi Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer
    Michael Wirtenberger
    Division of Molecular Genetic Epidemiology, Helmholtz University Group Molecular Epidemiology, German Cancer Research Center DKFZ Heidelberg, Germany
    Carcinogenesis 27:2201-8. 2006
    ..Owing to their impact on estrogen signaling, these polymorphisms might also influence adjuvant anti-estrogen therapy, using agents such as tamoxifen and raloxifen, and outcome of breast cancer patients...
  35. ncbi Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300
    J S Lee
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 9:1188-98. 1995
    ..of E1A to relieve YY1 repression was impaired by mutations that affect E1A binding to its associated protein p300. This suggests that E1A may modulate the repressor activity of YY1 by binding to p300, which may be physically ..
  36. pmc Regulation of human SRY subcellular distribution by its acetylation/deacetylation
    Laurie Thevenet
    Human Molecular Genetics Group, Institut de Genetique Humaine, CNRS UPR 1142, Montpellier, France
    EMBO J 23:3336-45. 2004
    ..In this study, we demonstrate that interaction of the human SRY with histone acetyltransferase p300 induces the acetylation of SRY both in vitro and in vivo at a single conserved lysine residue...
  37. doi The TRIM family protein KAP1 inhibits HIV-1 integration
    Awatef Allouch
    Molecular Biology Laboratory, Scuola Normale Superiore, Piazza dei Cavalieri 7, Pisa 56126, Italy
    Cell Host Microbe 9:484-95. 2011
    ..IN), a viral enzyme that is positively regulated by acetylation via the cellular histone acetyl transferase (HAT) p300. To investigate the relevance of IN acetylation, we searched for cellular proteins that selectively bind acetylated ..
  38. pmc Binding site specificity and factor redundancy in activator protein-1-driven human papillomavirus chromatin-dependent transcription
    Wei Ming Wang
    Simmons Comprehensive Cancer Center, Dallas, Texas 75390, USA
    J Biol Chem 286:40974-86. 2011
    ..HPV), and each AP-1 complex is capable of activating transcription from in vitro-reconstituted HPV chromatin in a p300- and acetyl-CoA-dependent manner...
  39. ncbi Six lysine residues on c-Myc are direct substrates for acetylation by p300
    Kangling Zhang
    Department of Chemistry, University of California at Riverside, Riverside, CA 92521, USA
    Biochem Biophys Res Commun 336:274-80. 2005
    ..Here, we have analyzed the acetylation of recombinant Myc:Max complexes by purified p300 HAT in vitro by using MALDI-TOF and LC-ESI-MS/MS mass spectrometry...
  40. pmc Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment
    Charles E Foulds
    Huntsman Cancer Institute, 2000 Circle of Hope, University of Utah, Salt Lake City, UT 84112 5550, USA
    Mol Cell Biol 24:10954-64. 2004
    ..resulted in enhanced transactivation by preferential recruitment of the coactivators CREB binding protein (CBP) and p300. We discovered this phosphorylation-augmented interaction in an unbiased affinity chromatography screen of HeLa ..
  41. pmc AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins
    Y C Peng
    Department of Dermatology, New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    J Virol 74:5872-9. 2000
    ..Mol. Cell. Biol. 17:7208-7219, 1997). We show here that AMF-1 also binds the transcriptional coactivator p300 in vitro and in vivo. E2 interacted weakly with p300...
  42. ncbi p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint
    Daniel Stauffer
    Department of Biochemistry, Oregon Health and Sciences University, Portland, Oregon 97201, USA
    J Biol Chem 282:9678-87. 2007
    The highly related acetyltransferases, p300 and CREB-binding protein (CBP) are coactivators of signal-responsive transcriptional activation...
  43. doi Intracellular distribution of p300 and its differential recruitment to aggresomes in breast cancer
    María E Fermento
    Laboratorio de Biología Básica del Cáncer, Instituto de Investigaciones Bioquímicas Bahía Blanca INIBIBB CONICET, Camino La Carrindanga Km 7, 8000, Bahia Blanca, Argentina
    Exp Mol Pathol 88:256-64. 2010
    It has been recently suggested that p300 cytoplasmic redistribution and degradation are important for controlling the availability and activity of the protein as a transcriptional coactivator...
  44. ncbi Role of Akt/protein kinase B in the activity of transcriptional coactivator p300
    J Chen
    Ottawa Health Research Institute, University of Ottawa, 725 Parkdale Avenue, Ottawa, Ontario K1Y 4E9, Canada
    Cell Mol Life Sci 61:1675-83. 2004
    ..The function of transcriptional coactivator p300 is required by many transcription factors to either activate or repress gene expression...
  45. pmc p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro
    Annika E Wallberg
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 22:7812-9. 2002
    ..This report investigates the Notch IC-interacting proteins, p300, PCAF, and Mastermind-like 1 (MAML1), in an in vitro transcription system with purified factors and naked DNA or ..
  46. pmc The HTLV-1 tax protein cooperates with phosphorylated CREB, TORC2 and p300 to activate CRE-dependent cyclin D1 transcription
    Y M Kim
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523 1870, USA
    Oncogene 29:2142-52. 2010
    ..of phosphorylated CREB (pCREB) in vitro, and together the Tax-pCREB complex recruits the cellular co-activator p300 to the promoter through this unconventional Tax-responsive element...
  47. pmc Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates
    Lata Balakrishnan
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 285:4398-404. 2010
    ..Acetylation of FEN1 by p300 inhibits its endonuclease activity, impairing flap cleavage, a seemingly undesirable effect...
  48. pmc Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB
    Lin Feng Chen
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, CA 94141, USA
    EMBO J 21:6539-48. 2002
    ..We now demonstrate that the p300 and CBP acetyltransferases play a major role in the in vivo acetylation of RelA, principally targeting lysines 218, ..
  49. pmc Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription
    Francesco Faiola
    Department of Biochemistry, University of California Riverside, Riverside, CA 92521, USA
    Mol Cell Biol 25:10220-34. 2005
    ..Here, we report a novel functional interaction between Myc TAD and the p300 coactivator-acetyltransferase...
  50. pmc CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53
    Dingding Shi
    Department of Cancer Biology, University of Massachusetts Medical School and University of Massachusetts Memorial Cancer Center, 364 Plantation Street, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 106:16275-80. 2009
    b>p300 and CREB-binding protein (CBP) act as multifunctional regulators of p53 via acetylase and polyubiquitin ligase (E4) activities...
  51. pmc Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha
    Steven J Freedman
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 99:5367-72. 2002
    ..by transactivation of hypoxia-responsive genes by hypoxia-inducible factor-1 (HIF-1) in complex with the CBP and p300 transcriptional coactivators...
  52. ncbi Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300
    K Nakashima
    Department of Molecular Cell Biology, Cell Fate Modulation Research Unit, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 101 0062, Japan
    Science 284:479-82. 1999
    ..The transcriptional coactivator p300 interacts physically with STAT3 at its amino terminus in a cytokine stimulation-independent manner, and with Smad1 ..
  53. ncbi Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo
    Maria Fousteri
    Department of Toxicogenetics, Leiden University Medical Center, Einthovenweg 20, 2333 RC Leiden
    Mol Cell 23:471-82. 2006
    ..CSB fulfills a key role as a coupling factor to attract histone acetyltransferase p300, nucleotide excision repair (NER) proteins, and CSA-DDB1 E3-ubiquitin ligase complex with the COP9 signalosome...
  54. pmc The proline repeat domain of p53 binds directly to the transcriptional coactivator p300 and allosterically controls DNA-dependent acetylation of p53
    David Dornan
    Cancer Research UK Laboratories, p53 Signal Transduction Group, Department of Molecular and Cellular Pathology, University of Dundee, Dundee DD1 9SY, United Kingdom
    Mol Cell Biol 23:8846-61. 2003
    The transcription coactivator p300 cannot acetylate native p53 tetramers, thus revealing intrinsic conformational constraints on p300-catalyzed acetylation...
  55. ncbi Polyubiquitination of p53 by a ubiquitin ligase activity of p300
    Steven R Grossman
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Science 300:342-4. 2003
    Rapid turnover of the tumor suppressor protein p53 requires the MDM2 ubiquitin ligase, and both interact with p300-CREB-binding protein transcriptional coactivator proteins...
  56. ncbi E6 oncoprotein represses p53-dependent gene activation via inhibition of protein acetylation independently of inducing p53 degradation
    Mary C Thomas
    Department of Biochemistry, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Mol Cell 17:251-64. 2005
    ..We demonstrate that E6 does not prevent p53 or p300 recruitment to the chromatin but inhibits p300-mediated acetylation on p53 and nucleosomal core histones...
  57. pmc HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator
    L K Felzien
    Departments of Internal Medicine and Biological Chemistry, Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109 0650, USA
    Proc Natl Acad Sci U S A 95:5281-6. 1998
    ..HIV transcription correlates with its ability to induce G2/M growth arrest, and this effect is mediated by the p300 transcriptional co-activator, which promotes cooperative interactions between the Rel A subunit of NF-kappaB and ..
  58. pmc Acetylation of the human T-cell leukemia virus type 1 Tax oncoprotein by p300 promotes activation of the NF-kappaB pathway
    Julie Lodewick
    Institute for Microbiological Research J M Wiame and Laboratory of Microbiology, Universite Libre de Bruxelles, 1, avenue Emile Gryson, B 1070 Brussels, Belgium
    Virology 386:68-78. 2009
    ..a pool of Tax molecules acetylated on lysine residue at amino acid position 346 by the transcriptional coactivator p300. Phosphorylation of Tax on serine residues 300/301 was a prerequisite for Tax localization in the nucleus and ..
  59. pmc Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300
    W Zhang
    Center for Retrovirus Research and Department of Veterinary Biosciences, The Arthur James Cancer Hospital and Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    J Virol 75:9885-95. 2001
    The highly conserved coadapters CREB binding protein (CBP) and p300 form complexes with CREB as well as other DNA binding transcription factors to modulate chromatin remodeling and thus transcription...
  60. ncbi Human ING1 proteins differentially regulate histone acetylation
    Diego Vieyra
    Department of Biochemistry, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Biol Chem 277:29832-9. 2002
    ..interact with proteins associated with histone acetyltransferase (HAT) activity, such as TRRAP, PCAF, CBP, and p300. Human ING1 immunocomplexes contain HAT activity, and overexpression of p33(ING1b), but not of p47(ING1a), induces ..
  61. doi The ins and outs of HIV-1 Tat
    Solène Debaisieux
    CPBS, UMR 5236 CNRS, Universite de Montpellier, 1919 Route de Mende, 34923, Montpellier Cedex 05, France
    Traffic 13:355-63. 2012
    ..This review focuses on some of the recently identified molecular details underlying the unusual transcellular transport pathway used by Tat, such as the role of the single Trp in Tat for its membrane insertion and translocation...
  62. pmc HIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic intervention
    Michael Kogan
    Department of Neuroscience, Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA 19140, USA
    Retrovirology 8:25. 2011
    ..In view of the pivotal functions of Vpr in virus infection, replication, and persistence of infection, this protein represents an attractive target for therapeutic intervention...
  63. ncbi HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas
    Michael J Gray
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcomb Boulevard, Houston, TX 77030, USA
    Oncogene 24:3110-20. 2005
    ..simultaneously to the VEGF promoter, where they form a molecular complex with the transcription coactivators CBP/p300 and Ref-1/APE...
  64. ncbi HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators
    R Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec H3T IE2, Canada
    Oncogene 20:800-11. 2001
    ..Rather, vIRF-1 interacted with the CBP/p300 coactivators and efficiently inhibited the formation of transcriptionally competent IRF-3-CBP/p300 complexes...
  65. ncbi Repression of p15INK4b expression by Myc through association with Miz-1
    P Staller
    Institute of Molecular Biology and Tumour Research, Emil Mannkopff Strabetae 2, 35033 Marburg, Germany
    Nat Cell Biol 3:392-9. 2001
    ..Alleles of c-myc that are unable to bind to Miz-1 fail to inhibit accumulation of p15INK4b messenger RNA in primary cells and are, as a consequence, deficient in immortalization...
  66. ncbi Mutations truncating the EP300 acetylase in human cancers
    S A Gayther
    Department of Oncology, University of Cambridge, Cambridge, UK
    Nat Genet 24:300-3. 2000
    ..Our data show that EP300 is mutated in epithelial cancers and provide the first evidence that it behaves as a classical tumour-suppressor gene...
  67. pmc Regulation of transcription factor YY1 by acetylation and deacetylation
    Y L Yao
    Department of Medical Microbiology and Immunology, Interdisciplinary Oncology Program, H Lee Moffitt Cancer Center and Research Institute, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    Mol Cell Biol 21:5979-91. 2001
    ..Previous studies have established that YY1 interacts with histone acetyltransferases p300 and CREB-binding protein (CBP) and histone deacetylase 1 (HDAC1), HDAC2, and HDAC3...
  68. pmc Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation
    Mari Shimura
    Department of Intractable Diseases, Research Institute, National Center for Global Health and Medicine, Shinjuku, Tokyo 162 8655, Japan
    J Cell Biol 194:721-35. 2011
    ..Notably, Vpr stimulated the acetylation of histone H3, whereas p300 RNAi attenuated the Vpr-induced displacement of HP1-α and PCS...
  69. ncbi A p300 protein as a coactivator of GATA-6 in the transcription of the smooth muscle-myosin heavy chain gene
    H Wada
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan
    J Biol Chem 275:25330-5. 2000
    ..In addition, we show that the transcriptional coactivator p300 associated with GATA-6 during the transcription of the Sm-MHC gene...
  70. ncbi Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain
    Shiraz Mujtaba
    Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    Mol Cell 9:575-86. 2002
    ..activity is dependent on lysine acetylation and its association with nuclear histone acetyltransferases p300/CBP (CREB binding protein) and p300/CBP-associated factor (PCAF)...
  71. ncbi Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription
    Marc Tini
    Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell 9:265-77. 2002
    ..We report that TDG associates with transcriptional coactivators CBP and p300 and that the resulting complexes are competent for both the excision step of repair and histone acetylation...
  72. ncbi Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation
    N Billon
    Differentiation and Cell Cycle Group, Laboratoire de Biologie Moleculaire et Cellulaire, UMR 49 CNRS Ecole Normale Supérieure de Lyon, France
    Oncogene 18:2872-82. 1999
    ..The addition of NGF resulted in an accumulation of the transcriptional co-activator p300 in complexes associated with the NGF-responsive region...
  73. pmc Posttranslational modifications of HIV-1 integrase by various cellular proteins during viral replication
    Yingfeng Zheng
    Laboratory of Molecular Human Retrovirology, Department of Medical Microbiology, University of Manitoba, 508 730 William Avenue, Winnipeg R3E 0W3, Canada
    Viruses 5:1787-801. 2013
    ..A number of host cellular proteins, including Lens Epithelium-derived Growth factor (LEDGF/p75), p300 and Ku70 have been shown to interact with IN and be involved in the PTM process of IN, either facilitating or ..
  74. doi Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1
    Paul O Hassa
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Mol Biol 377:668-78. 2008
    ..and human immunodeficiency virus 1 long terminal repeat promoters in concert with the transcriptional coactivators p300/CREB binding protein, CARM1, and poly(ADP-ribose) polymerase 1...
  75. doi Mapping acetylation sites in E2A identifies a conserved lysine residue in activation domain 1 that promotes CBP/p300 recruitment and transcriptional activation
    Brandy D Hyndman
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, Canada
    Biochim Biophys Acta 1819:375-81. 2012
    ..E2A proteins can interact directly with the transcriptional co-activators and lysine acetyltranferases (KATs) CBP, p300 and PCAF to induce target gene transcription...
  76. pmc Absence of p300 induces cellular phenotypic changes characteristic of epithelial to mesenchyme transition
    D Krubasik
    Department of Oncology, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
    Br J Cancer 94:1326-32. 2006
    b>p300 is a transcriptional cofactor and prototype histone acetyltransferase involved in regulating multiple cellular processes. We generated p300 deficient (p300-) cells from the colon carcinoma cell line HCT116 by gene targeting...
  77. doi p300 provides a corepressor function by cooperating with YY1 and HDAC3 to repress c-Myc
    N Sankar
    Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Oncogene 27:5717-28. 2008
    We showed earlier that p300/CBP plays an important role in G1 progression by negatively regulating c-Myc and thereby preventing premature G1 exit...
  78. ncbi Thyroid transcription factor 1 rescues PAX8/p300 synergism impaired by a natural PAX8 paired domain mutation with dominant negative activity
    Helmut Grasberger
    The University of Chicago, MC3090, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Mol Endocrinol 19:1779-91. 2005
    ..we found that in nonthyroid cells, the acetylation-independent synergism with the general transcriptional adaptor p300 is completely abrogated, suggesting that PAX8-S48F may be unable to efficiently recruit p300...
  79. pmc Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53
    David Dornan
    CRUK Interferon and Cell Signalling Group, Cell Signalling Unit, Cancer Research Centre, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, United Kingdom
    Mol Cell Biol 24:10083-98. 2004
    ..by IRF-1 does not require its DNA-binding activity but relies on the ability of IRF-1 to bind the coactivator p300 and to stimulate p53-dependent transcription by an allosteric mechanism...
  80. pmc Proteasomal inhibition attenuates transcriptional activity of hypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1alpha C-terminal activation domain
    Stefan Kaluz
    Department of Microbiology and Molecular Genetics, Medical Science I B210, University of California at Irvine, College of Medicine, Irvine, CA 92697 4025, USA
    Mol Cell Biol 26:5895-907. 2006
    ..PI specifically inhibited the HIF-1 alpha CAD despite activating the HIF-1 alpha coactivator p300 and another p300 cysteine/histidine-rich domain 1-dependent transcription factor, STAT-2...
  81. pmc Regulation of beta -catenin transformation by the p300 transcriptional coactivator
    Y Sun
    Vaccine Research Center, National Institutes of Health, 40 Convent Drive, Bethesda, MD 20892 3005, USA
    Proc Natl Acad Sci U S A 97:12613-8. 2000
    ..We report that the transcriptional coactivator p300 interacts with beta-catenin in vitro and in vivo and is critical for beta-catenin-mediated neoplastic ..
  82. ncbi Stat3 dimerization regulated by reversible acetylation of a single lysine residue
    Zheng Long Yuan
    Department of Surgery, Brown University Medical School Rhode Island Hospital, Providence, RI 02903, USA
    Science 307:269-73. 2005
    ..Histone acetyltransferase p300-mediated Stat3 acetylation on Lys685 was reversible by type I histone deacetylase (HDAC)...
  83. ncbi The expression levels of the transcriptional regulators p300 and CtBP modulate the correlations between SNAIL, ZEB1, E-cadherin and vitamin D receptor in human colon carcinomas
    Cristina Peña
    Department of Medical Oncology, Hospital Universitario Puerta de Hierro, Madrid, Spain
    Int J Cancer 119:2098-104. 2006
    ..The mRNA expression levels of SNAIL and ZEB1, and of transcriptional regulators p300 and CtBP, were measured by RT-PCR in tumor and normal tissue from 101 colon carcinoma patients...
  84. pmc The biphasic redox sensing of SENP3 accounts for the HIF-1 transcriptional activity shift by oxidative stress
    Ying Wang
    Department of Biochemistry and Molecular Cell Biology, Key Laboratory of the Shanghai Science and Technology Commission for Cancer Microenvironment and Inflammation, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, China
    Acta Pharmacol Sin 33:953-63. 2012
    ..To investigate the mechanisms underlying the biphasic redox regulation of hypoxia-inducible factor-1 (HIF-1) transcriptional activity under different levels of oxidative stress caused by reactive oxidative species (ROS)...
  85. pmc p300-Dependent ATF5 acetylation is essential for Egr-1 gene activation and cell proliferation and survival
    David X Liu
    Departments of Neural and Behavioural Sciences, Penn State University College of Medicine, Hershey, PA 17033, USA
    Mol Cell Biol 31:3906-16. 2011
    ..We demonstrate here that ATF5 interacts with the transcriptional coactivator p300, which acetylates ATF5 at lysine-29 (K29), which in turn enhances the interaction between ATF5 and p300 and binding ..
  86. pmc SIRT1 deacetylates APE1 and regulates cellular base excision repair
    Tohru Yamamori
    University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Nucleic Acids Res 38:832-45. 2010
    ..These findings identify APE1 as a novel protein target of SIRT1, and suggest that SIRT1 plays a vital role in maintaining genomic integrity through regulation of the BER pathway...
  87. ncbi Binding and modulation of p53 by p300/CBP coactivators
    N L Lill
    The Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 387:823-7. 1997
    The adenovirus E1A and SV40 large-T-antigen oncoproteins bind to members of the p300/CBP transcriptional coactivator family. Binding of p300/CBP is implicated in the transforming mechanisms of E1A and T-antigen oncoproteins...
  88. doi Transcriptional upregulation of HIF-1α by NF-κB/p65 and its associations with β-catenin/p300 complexes in endometrial carcinoma cells
    Tsutomu Yoshida
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan
    Lab Invest 93:1184-93. 2013
    ..In addition, HIF-1α was indirectly associated with nuclear β-catenin through interactions with p300, leading to slight enhancement of both HIF-1α- and β-catenin-mediated transcriptional activity...
  89. pmc A rearranged EP300 gene in the human B-cell lymphoma cell line RC-K8 encodes a disabled transcriptional co-activator that contributes to cell growth and oncogenicity
    Michael R Garbati
    Department of Biology, Boston University, Boston, MA 02215, USA
    Cancer Lett 302:76-83. 2011
    ..RC-K8 has an altered EP300 locus that encodes a C-terminally truncated histone acetyltransferase (HAT) protein (p300ΔC)...
  90. pmc Regulation of the cyclin-dependent kinase inhibitor 1A gene (CDKN1A) by the repressor BOZF1 through inhibition of p53 acetylation and transcription factor Sp1 binding
    Min Kyeong Kim
    Department of Biochemistry and Molecular Biology, Brain Korea 21 Project for Medical Science, Severance Biomedical Research Institute, Yonsei University School of Medicine, 134 Shinchon dong, Seodaemoon ku, Seoul 120 752, Korea
    J Biol Chem 288:7053-64. 2013
    ..In addition, BOZF1 interacted with p53 and decreased the acetylation of p53 by p300, which reduced the DNA binding activity of p53 at the far distal p53-binding element...
  91. ncbi Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation
    Katrin Kaehlcke
    Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    Mol Cell 12:167-76. 2003
    The HIV transcriptional activator Tat is acetylated by p300 at a single lysine residue in the TAR RNA binding domain. We have generated monoclonal and polyclonal antibodies specific for the acetylated form of Tat (AcTat)...
  92. doi Menadione and ethacrynic acid inhibit the hypoxia-inducible factor (HIF) pathway by disrupting HIF-1α interaction with p300
    Yu Ran Na
    Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14 gil 5, Seongbuk gu, Seoul 136 791, Republic of Korea
    Biochem Biophys Res Commun 434:879-84. 2013
    ..factor (HIF)-1α that elicits transcriptional activity through recruitment of the CREB binding protein (CBP)/p300 coactivator...
  93. ncbi p300/cAMP-responsive element-binding protein interactions with ets-1 and ets-2 in the transcriptional activation of the human stromelysin promoter
    G Jayaraman
    Lurie Cancer Center and Microbiology and Immunology Department, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 274:17342-52. 1999
    In this paper we show that transcription factors Ets-1 and Ets-2 recruit transcription adapter proteins p300 and CBP (cAMP-responsive element-binding protein) during the transcriptional activation of the human stromelysin promoter, which ..
  94. pmc CBP-mediated FOXO-1 acetylation inhibits pancreatic tumor growth by targeting SirT
    Kartick C Pramanik
    Corresponding Author Sanjay K Srivastava, Department of Biomedical Sciences, Suite 1103, Texas Tech University Health Sciences Center, 1406 Coulter Drive, Amarillo, TX 79106
    Mol Cancer Ther 13:687-98. 2014
    ..Taken together, our results suggest that capsaicin activated JNK and FOXO-1, leading to the acetylation of FOXO-1 through CBP and SirT-1. Acetylated FOXO1 induced apoptosis in pancreatic cancer cells through BIM activation...
  95. pmc Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity
    Kishor K Bhakat
    Sealy Center for Molecular Science and Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 1079, USA
    Nucleic Acids Res 32:3033-9. 2004
    ..Here we show that the transcriptional coactivator p300 stably interacts with, and acetylates, the recently discovered human DNA glycosylase NEIL2, involved in the repair ..
  96. doi Phosphorylation of p300 increases its protein degradation to enhance the lung cancer progression
    Shao An Wang
    Institute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan
    Biochim Biophys Acta 1843:1135-49. 2014
    b>p300 is a transcription cofactor for a number of nuclear proteins. Most studies of p300 have focused on the regulation of its function, which primarily includes its role as a transcription co-factor for a number of nuclear proteins...
  97. doi Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1
    Hyun Jin Kang
    Authors Affiliations College of Pharmacy and Bio MAX institute, Research Institute of Pharmaceutical Sciences and College of Veterinary Medicine, BK21 Plus Program for Veterinary Science, Seoul National University, Seoul, Korea
    Cancer Res 74:1484-94. 2014
    ....
  98. pmc Modulation of histone acetyltransferase activity through interaction of epstein-barr nuclear antigen 3C with prothymosin alpha
    M A Cotter
    Department of Microbiology and Immunology and Cellular and Molecular Biology Program, University of Michigan Medical School, University of Michigan Medical Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Biol 20:5722-35. 2000
    ..Additionally, we show that EBNA3C also interacts with p300, a cellular acetyltransferase...
  99. pmc Human Kruppel-related 3 (HKR3) is a novel transcription activator of alternate reading frame (ARF) gene
    Jae Hyeon Yoon
    From the Department of Biochemistry and Molecular Biology, Brain Korea 21 PLUS Project for Medical Science, Severance Biomedical Science Institute, Yonsei University School of Medicine, 50 Yonsei ro, Seodaemun gu, Seoul 120 752, Korea
    J Biol Chem 289:4018-31. 2014
    ..HKR3 interacted with the co-activator p300 to activate ARF transcription, which increased the acetylation of histones H3 and H4 within the proximal promoter...
  100. pmc Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation
    Vesna Rapić-Otrin
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, E1240 BST, Pittsburgh, PA 15261, USA
    Nucleic Acids Res 30:2588-98. 2002
    ..In addition, we find that the p127 subunit of UV-DDB binds in vivo to p300, a histone acetyltransferase...
  101. ncbi Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300
    H Chen
    Howard Hughes Medical Institute, School of Medicine, University of California at San Diego, La Jolla 92037, USA
    Cell 90:569-80. 1997
    ....

Research Grants70

  1. Lead exposure, externalizing behavior, and neurobiological mediating factors
    Jianghong Liu; Fiscal Year: 2013
    ..Lead exposure is hypothesized to give rise to two related symptoms, cognitive impairment (low IQ, reduced P300 event- related potentials, poor school performance) and emotion dysregulation (low vagal tone, low arousal, and low ..
  2. ALCOHOL, P3 TOPOGRAPHY & FAMILY HISTORY OF ALCOHOLISM
    JORGE DARUNA; Fiscal Year: 1991
    ..The proposed study will focus on the P300 component of event-related potentials...
  3. Understanding and enhancing visual search performance in complex scenes
    MELISSA LE HOA VO; Fiscal Year: 2012
    ..neural correlates that might evolve in the course of training using electroencephalography (EEG), namely the P300 and the N2pc...
  4. Paradigm and attentional manipulations to improve P300-based BCI
    Eric Sellers; Fiscal Year: 2010
    ..The current proposal will address three factors that can significantly improve P300-based BCI performance. First, we will manipulate matrix size from the traditional 6x6 to an 8x9 matrix...
  5. Tilt/Recline Adjustment by Subjects with ALS using Brain Computer Interfaces
    Jane Huggins; Fiscal Year: 2009
    ..proposed work will address the overall research question: "How well can subjects with ALS use a BCI based on the P300 response in electroencephalogram (EEG) to operate a power wheelchair tilt/recline system in their home environments?..
  6. EVENT RELATED POTENTIALS IN OLDER SCHIZOPHRENIA PATIENTS
    John Olichney; Fiscal Year: 1999
    DESCRIPTION (Adapted from applicant's abstract): Specific Aims: To examine the P300 and N4OO Event-Related Potentials (ERPs) in a well-characterized cohort of older schizophrenia patients, with comparably aged samples of patients with ..
  7. EVOKED POTENTIALS: EARLY ALZHEIMERS DISEASE DETECTION
    KENNETH ERICKSON; Fiscal Year: 1993
    ..specific aims of the proposed study are to: 1) Replicate the investigators preliminary findings of diminished N200-P300 amplitude and prolonged P300 latency in mild AD, using a larger, carefully selected and neuropsycholigically ..
  8. Regulation of LPS-mediated HMGB1 Release by Poly (ADP-ribose) Polymerase-1
    RAJESH K ANEJA; Fiscal Year: 2013
    ..modulates extracellular signal-regulated kinase (ERK) 1/2-mediated histone acetyl-transferase (HAT) activity of p300 and a closely related protein, cAMP response element-binding protein (CREB)-binding protein (CBP);3) PARP-1 ..
  9. Genomic approaches to inner ear hair cell regeneration
    Michael Lovett; Fiscal Year: 2010
    ..utricle-specific enhancer elements using ChIP-Seq methods and an antibody to the enhancer-associated co-factor p300. By correlating these three sets of data we expect to gain insights into which genes, which microRNAs and which ..
  10. Role of histone acetyltransferases in memory storage and synaptic plasticity
    MARCEL ANDRE ESTEVEZ; Fiscal Year: 2012
    ..like CREB, but also transcriptional coactivators, such as the paralogous factors CREB- binding protein (CBP) and p300. CBP and p300 are potent histone acetyltransferases (HATs) that coordinately regulate gene activity in a cell type- ..
  11. Acetylation-Dependent IFN Signal Transduction
    Y Eugene Chin; Fiscal Year: 2010
    ..acetylation by recruiting tumor suppressor-like transcription cofactor CREB-binding protein (CBP) or its homologous p300. Acetylated IFNR2 can then recruit IRF9...
  12. Cannabidiol Modulation of ???-9-THC???s Psychotomimetic Effects in Healthy Humans
    Mohini Ranganathan; Fiscal Year: 2012
    ..effects (measured on a visual analog scale of mood states for anxiety and euphoria), psychophysiological effects (P300 event related potential) and endocrine effects (serum ACTH, cortisol and prolactin levels)...
  13. Bipolar &Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Godfrey D Pearlson; Fiscal Year: 2012
    ..We will obtain measures of neurophysiology (e.g., eye tracking, P50 gating, PPI, and P300), neurocognition (e.g., attention/vigilance, episodic and working memory), and brain structure (e.g...
  14. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Matcheri S Keshavan; Fiscal Year: 2010
    ..We will obtain measures of neurophysiology (e.g., eye tracking, P50 gating, PPI, and P300), neurocognition (e.g., attention/vigilance, episodic and working memory), and brain structure (e.g...
  15. Bipolar &Schizophrenia Consortium for Parsing Intermediate Phenotypes
    John A Sweeney; Fiscal Year: 2010
    ..We will obtain measures of neurophysiology (e.g., eye tracking, P50 gating, PPI, and P300), neurocognition (e.g., attention/vigilance, episodic and working memory), and brain structure (e.g...
  16. Bipolar &Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Carol A Tamminga; Fiscal Year: 2012
    ..We will obtain measures of neurophysiology (e.g., eye tracking, P50 gating, PPI, and P300), neurocognition (e.g., attention/vigilance, episodic and working memory), and brain structure (e.g...
  17. Psychometric and Neurobiological Mechanisms of Impulse Control Disorders
    Lindsay Nelson; Fiscal Year: 2010
    ..Primary ERP measures of interest include: (1) variants of the P300, an index of cognitive processing known to function as an endophenotype of externalizing proneness, and (2) the ..
  18. Mechanism of CREB dysregulation in Alzheimer brain
    Subbiah Pugazhenthi; Fiscal Year: 2013
    ..STAT-1 and NF-?B, the transcriptions factors that compete with CREB for the limited pool of coactivators, CBP and p300. (iii) Inflammation can direct CREB to pathways other than those needed for neuronal function...
  19. BIOLOGICAL RISK FACTORS IN RELATIVES OF ALCOHOLIC WOMEN
    Shirley Y Hill; Fiscal Year: 2013
    ..A total of 1167 day long clinical evaluations, measures of environmental variation, ERP recordings to identify P300 amplitude have been performed that spans childhood, adolescence and young adulthood...
  20. Longitudinal Predictors of Alcohol Dependence in Offspring of Multiplex Families
    Shirley Y Hill; Fiscal Year: 2013
    ..Aim 4 will investigate the relationship between right OFC volume and P300 trajectories and SUD outcome...
  21. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2011
    ..Mass spectrometry analysis of PRDM16 transcriptional complexes showed that PRDM16 associates with p300/CBP in brown adipocyteswhether this acetyltransferase complex mediates activation of PPARs remains to be tested...
  22. Maternal Obesity affects AMP-Kinase in Muscle Cell Differentiation
    Min Du; Fiscal Year: 2013
    ..AMPK also phosphorylates p300, which is expected to impair its function as a co-activator, and p300 is a necessary co-activator for transcription ..
  23. Beta-cell Proliferation
    Fredric E Wondisford; Fiscal Year: 2013
    ..Phosphorylated CREB recruits the nuclear co-activators CREB binding protein (CBP), and the related protein p300, which stimulate gene transcription through histone deacetylase activity and stimulating RNA polymerase...
  24. Nuclear Receptor Coactivator Functions and Mechanisms
    Robert G Roeder; Fiscal Year: 2013
    ..such as RIP140) that necessitate opposing coactivator functions, histone modifying factors such as the activating p300 acetyl- and SET1/MLL methyl-transferases, and other DNA-binding regulatory factors (C/EBPs) that act ..
  25. HTS development for targeted anti-fungal small molecules
    Paul D Kaufman; Fiscal Year: 2010
    ..Rtt109 is very distantly related the mammalian p300/CBP HAT enzyme, but compounds that inhibit p300/CBP do not inhibit Rtt109...
  26. Nuclear Events in PTH Action on Bone
    Nicola C Partridge; Fiscal Year: 2013
    ..In the nucleus, Runx2 then recruits the histone acetyl transferases (HATs), p300 and p300/CBP associated factor (PCAF)...
  27. Prevention of acute GvHD by inhibition of cdk2
    Vassiliki A Boussiotis; Fiscal Year: 2012
    ..Cdk2 directly regulates expression of genes including NF?B, Sp1, p300/CBP, and subunits of the RNA polymerase...
  28. DEVELOPMENT OF SPLIT DAMID AS AN ALTERNATIVE METHODOLOGY TO CHROMATIN IMMUNOPRECI
    Raphael Kopan; Fiscal Year: 2010
    ..health related factors (Notch, DeltaFosB, CREB, NF[unreadable]B, and Mef2) and common transcription co-activators (p300, others) to reconstitute Dam activity only at sites where transcription takes place...
  29. C/EBP, atrogin-1, and muscle wasting
    Per Olof Hasselgren; Fiscal Year: 2009
    ..the expression and activity of transcription factors and nuclear cofactors, such as the histone acetyl transferase p300, are involved in the loss of muscle mass in catabolic conditions...
  30. Role of Cited2 in Hematopoiesis
    Yu Chung Yang; Fiscal Year: 2011
    Cited2 [CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2] is one of the founding members of a new family of transcriptional modulators...
  31. MAP KINASE IN ISLET FUNCTION
    Melanie H Cobb; Fiscal Year: 2013
    ..events that control insulin gene transcription by focusing on mechanisms of recruitment of the coactivator p300. These studies should provide new understanding of how amino acids regulate insulin production, stability and ..
  32. Regulation of Hepatic Gluconeogenesis by the CREB:TORC2 Pathway
    Marc R Montminy; Fiscal Year: 2010
    ..Preliminary studies indicate that TORC2 is transiently activated through P300-dependent acetylation during early fasting, when it stimulates the gluconeogenic program via an association with a ..
  33. Regulation of Hepatic Gluconeogenesis by the CREB:TORC2 Pathway
    Marc R Montminy; Fiscal Year: 2013
    ..Preliminary studies indicate that TORC2 is transiently activated through P300-dependent acetylation during early fasting, when it stimulates the gluconeogenic program via an association with a ..
  34. E2-Cellular Complexes in HPV Chromatin Transcription
    Cheng Ming Chiang; Fiscal Year: 2013
    ..transcription system that we have developed to define the role of cellular chromatin-modifying enzymes, including p300 and CBP histone acetyltransferases (HATs), in AP-1-dependent activation of HPV chromatin transcription...
  35. Role of aberrant organelle stress responses in alcohol-induced liver injury
    Cheng Ji; Fiscal Year: 2012
    ..XBP-1, CHOP, ATF6, ATF4, CREB, TORC3, PGC-1a), general transcription factors (Pol II, NF-Y, NFR, Sp1, TBP and p300) and epigenetic marks (methylation of H3-K4 and H3-K79 and acetylation of H3 and H4) in promoters of mitochondrial ..
  36. Role of Protein Acetylation in Ncx1 Expression
    Donald R Menick; Fiscal Year: 2012
    ..5 leading to the recruitment of p300 and upregulation of the Ncx1 promoter...
  37. Identification of a Molecular Signature for Barrier Insulators
    LAURIE ANN STEINER; Fiscal Year: 2013
    ..the USF proteins, their associated histone methyltransferases (PRMT1, PRMT4, SET7/9), and acetyltransferases (CBP, P300, PCF), as well as an active chromatin structure (H3Ac, H4Ac, H3K4me2)...
  38. REGULATION OF GROWTH FACTORS AND EMBRYOGENESIS
    ARNOLD RIZZINO; Fiscal Year: 2005
    ..mediate its effects? Recent studies argue that Sox-2 and Oct-3 can mediate their effects through the co-activators p300 and CBP (p300/CBP)...
  39. Regulation of CFTR gene expression
    Martin Walsh; Fiscal Year: 2004
    ..examine whether transcription factors ATF1 and CBF/NF-Y and the histone acetyltransferase coactivator proteins, p300/CREB-binding protein (p300/CBP) and p300/CBP-associated factor (PCAF) mediate histone acetylation of CFTR...
  40. Targeting the Obesity-Inflammation-COX-Aromatase Axis to Lower Breast Cancer Risk
    ANDREW JESS DANNENBERG; Fiscal Year: 2013
    ..PGE2, BRCA1, histone acetylation and aromatase induction, based on our novel data implicating BRCA1, Sirt-1 and CBP/p300 in PGE2-mediated aromatase induction...
  41. Characterization of Enhancers in the Epidermal Differentiation Complex
    CRISTINA DE GUZMAN STRONG; Fiscal Year: 2012
    ..from Washington University: In Specific Aim 2B, we will also determine if these CNS EDC map to regions bound by p300 and monomethylated H3K4 enriched in enhancer sequences using chromatin immunoprecipitation (ChIP)...
  42. Human tendon stem progenitor cell aging and regeneration
    Hui Bin Sun; Fiscal Year: 2013
    ..Our preliminary study indicates that the transcription factor CITED2 (CREB-binding protein/p300-interacting transactivator with ED- rich tail), a cell growth regulator and potent suppressor of cel senescence, is ..
  43. Mechanism and inhibition of SREBP-dependent cholesterol/lipid metabolism
    Gerhard Wagner; Fiscal Year: 2013
    ..by SREBPs, demonstrating a central role for the MED15 subunit of the Mediator co-activator complex and the CBP/p300 acetyltransferases...
  44. CBP Bromodomain Antagonists Block Androgen Receptor in Prostate Cancer
    SYED S MUJTABA; Fiscal Year: 2010
    ..Resultantly, AR remains a valuable therapeutic target due to this organ specificity. Although it is known that CBP/p300 (CREB binding protein) mediated lysine acetylation of AR (ARKac) plays a vital role in AR activation and control of ..
  45. HAT Inhibition to Impair Foxp3+ Treg Function and Boost Anti-Tumor Immunity
    WAYNE WILLIAM HANCOCK; Fiscal Year: 2013
    ..approaches affect Treg function in vitro? Since preliminary data points to roles for the HATs, PCAF and p300, in control of Treg suppression, we will analyze the relative contribution of these HATs to regulation of Treg vs...
  46. EBNA3C and tumor supressors
    Erle S Robertson; Fiscal Year: 2010
    ..We will investigate the recruitment of acetylases including p300 and CBP by EBNA3C to determine its ability to modify p53 through acetylation and whether or not phosphorylation is ..
  47. Functional Definition of MYC Acetylation
    MATTHEW THOMAS HURD; Fiscal Year: 2013
    ..e., GCN5 and p300)...
  48. Opposing and complementary roles of KLF1 and KLF2 in erythropoiesis
    Joyce A Lloyd; Fiscal Year: 2012
    ..knockout (KO) mouse models will be used to determine if KLF1 and KLF2 are required for recruitment of BRG1 and CBP/p300 chromatin remodeling complexes to the [unreadable]-globin LCR and promoters...
  49. Effect of chromatin remodelers/modifiers on HIV-1 Tat activated transcription
    Fatah Kashanchi; Fiscal Year: 2010
    ..level in HIV-1 infected cells by binding the trans-activation response region (TAR) and recruiting cdk9/cyclin T1, p300/CBP, SWI/SNF, and RNA Polymerase II. Sustained HIV-1 replication further progresses infected T cells towards AIDS...
  50. Investigation of Sox9 target genes in the pancreas
    REBECCA BEER; Fiscal Year: 2013
    ..The work will be supplemented with coursework in data analysis and statistics. Ultimately, the multidisciplinary nature of my postdoctoral training will propel me into my desired career as an academic PI. ..
  51. Determination of the role of CBP and p300 mediated Wnt signaling on colonic cells
    Michael Bordonaro; Fiscal Year: 2010
    ..in the association between beta-catenin and the transcriptional coactivators CREB binding protein (CBP) and p300. Association of CBP with beta-catenin is thought to activate a set of genes linked to cell proliferation, while the ..
  52. Identifying enhancers with human-specific developmental functions
    James P Noonan; Fiscal Year: 2013
    ..conjunction with computational and experimental filters, such as extreme evolutionary constraint and recruitment of p300, to predict enhancers and mouse transgenic technologies to identify and characterize enhancers with human-specific ..
  53. Mechanisms of p53 activation in tumorsuppression
    Wei Gu; Fiscal Year: 2012
    ..In our early studies, we found that histone acetyltransferase CBP/p300 promotes p53-dependent transcription by directly acetylating lysine residues in the C-terminal region of p53...
  54. Histone Acetylation and Insulin Gene Expression
    Sabire Ozcan; Fiscal Year: 2010
    ..by causing hyperacetylation of histone H4 at the insulin promoter via the recruitment of the histone acetylase p300 by Pdx-1...
  55. Role of Cited2 in lens development and hyaloid vascular regression
    Yu Chung Yang; Fiscal Year: 2010
    Cited2 (CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2) is a founding member of a new family of transcriptional modulators...
  56. Regulation of p53 Transcription by Viral Oncoproteins &Covalent Modifications
    Cheng Ming Chiang; Fiscal Year: 2012
    ..We found that both p53 and histone acetyltransferase (HAT) p300 are essential for E6-mediated repression of p21 gene transcription...
  57. Using AKT1 and 2 and Rb1 to approach MyoD binding mechanisms genome-wide
    Sandra B Sharp; Fiscal Year: 2012
    ..MyoD binding at numerous muscle-specific genes is facilitated by phosphorylation of the histone acetyl transferase p300 by the protein kinases AKTs 1 and 2, the consequent association of p300 with MyoD, and the removal of HDAC1 from ..
  58. Functional analysis of leukemic CREBBP mutations
    Charles G Mullighan; Fiscal Year: 2013
    ..the two genes encoding the KAT3 family of histone acetyltransferases, CREB-binding protein (CBP, CREBBP) and EP300 (p300). ALL is the most common childhood cancer and the focus of this proposal...
  59. Transcriptional Coactivators and Pregnancy Outcomes
    Robert M Greene; Fiscal Year: 2012
    ..Specifically, we propose that not only is proper expression of Folbp and transcriptional coactivators such as CBP, p300, Cited2, Cart1, and AP-2 requisite for CNS formation, but the integration of these molecules into a functional ..
  60. Effects of Acitretin on the activation of latent HIV
    Peilin Li; Fiscal Year: 2013
    ..IRF-1 also can interact with HAT, such as p300/CBP (cAMP-responsive-element-binding factor (CREB)-binding protein) to evoke HIV transcription from the LTR in the ..
  61. RENIN CELL FATE IN THE KIDNEY VASCULATURE
    ROBERTO ARIEL GOMEZ; Fiscal Year: 2013
    ..that the transcriptional effects of cAMP are mediated by the binding of CREB and histone acetyl transferases CBP/p300 to the cAMP response element (CRE) located in the enhancer region ofthe renin gene...
  62. Testing the role of chromatin in healthspan
    Nikolai A Timchenko; Fiscal Year: 2012
    ..To achieve this goal we generated a transgenic mouse that expresses the CH3 domain of the p300 (CH3p300)...
  63. Transcriptional Regulation by the HTLV-1 Tax Protein
    Jennifer K Nyborg; Fiscal Year: 2013
    ..Together, this complex recruits the cellular coactivators CBP/p300, which is a fundamental step in transcriptional activation of HTLV-1...
  64. Role of MN1-TEL and MN1 in Leukemogenesis
    Gerard C Grosveld; Fiscal Year: 2010
    ..Although we determined that MN1 can interact with the transcription coactivators p300 and RAC and stimulates transcription of the retinoic acid receptor in HeLa cells, we know little about the ..
  65. Regulation of HTLV-1 and cellular gene transcription by the viral protein HBZ
    ISABELLE MICHELE LEMASSON; Fiscal Year: 2013
    ..We found that HBZ also binds directly to the cellular coactivators p300 and CBP, which is mediated through regions of the viral protein outside its bZIP domain...
  66. Role of Cited2 in Lung Development
    Yu Chung Yang; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Cited2 [CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2] is one of the founding members of a new family of transcriptional activators...
  67. Role of the Acetyltransferase p300 in Cellular Responses
    Maria Avantaggiati; Fiscal Year: 2006
    ..We made the novel finding that a transcription coactivator possessing acetyltransferase activity, p300, enhances the mitotic arrest elicited by taxol...
  68. CONTROL OF P53 TUMOR SUPPRESSOR BY CBP/P300
    Tso Pang Yao; Fiscal Year: 2005
    ..application): The long-term objective of this proposal is to elucidate the function of CBP and its family member p300 in cellular growth and oncogenesis...
  69. Mechanism of HTLV-1 Tax-mediated activation of CDK6 transcription.
    ISABELLE MICHELE LEMASSON; Fiscal Year: 2010
    ..These complexes nucleate the formation of a preinitiation complex that notably includes the coactivator p300, which is recruited directly by Tax...
  70. Genetic architecture of alcohol misuse candidate endophenotypes
    Godfrey D Pearlson; Fiscal Year: 2010
    ..We will also obtain an auditory oddball P300 event related potential assessment in all subjects undergoing imaging and derive event-related oscillation (ERO) ..