Gene Symbol: P2Y11
Description: purinergic receptor P2Y11
Alias: P2Y11, P2Y purinoceptor 11, purinergic receptor P2Y, G-protein coupled, 11
Species: human
Products:     P2Y11

Top Publications

  1. Communi D, Suarez Huerta N, Dussossoy D, Savi P, Boeynaems J. Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes. J Biol Chem. 2001;276:16561-6 pubmed
    ..There are very few examples of intergenic splicing in mammalian cells, and this is the first case involving a G-protein-coupled receptor. ..
  2. Vaughan K, Stokes L, Prince L, Marriott H, Meis S, Kassack M, et al. Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor. J Immunol. 2007;179:8544-53 pubmed
    ..Neutrophils were shown to express the P2Y11 receptor and inhibition of P2Y11 signaling using the antagonist NF157 abrogated the ATP-mediated delay of ..
  3. Amisten S, Melander O, Wihlborg A, Berglund G, Erlinge D. Increased risk of acute myocardial infarction and elevated levels of C-reactive protein in carriers of the Thr-87 variant of the ATP receptor P2Y11. Eur Heart J. 2007;28:13-8 pubmed
    Extracellular ATP acting on the P2Y11 receptor regulates inflammatory cells. We hypothesized that polymorphisms in the receptor could influence the risk of acute myocardial infarction (AMI)...
  4. Communi D, Govaerts C, Parmentier M, Boeynaems J. Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase. J Biol Chem. 1997;272:31969-73 pubmed
    Clones encoding a new human P2Y receptor, provisionally called P2Y11, have been isolated from human placenta complementary DNA and genomic DNA libraries. The 1113-base pair open reading frame is interrupted by one intron...
  5. Kornum B, Kawashima M, Faraco J, Lin L, Rico T, Hesselson S, et al. Common variants in P2RY11 are associated with narcolepsy. Nat Genet. 2011;43:66-71 pubmed publisher
    ..0007) and natural killer cells (P = 0.001). These results identify P2RY11 as an important regulator of immune-cell survival, with possible implications in narcolepsy and other autoimmune diseases...
  6. Moore D, Chambers J, Wahlin J, Tan K, Moore G, Jenkins O, et al. Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study. Biochim Biophys Acta. 2001;1521:107-19 pubmed
    ..Our extensive expression data indicate the many potentially important roles of P2Y receptors throughout the human body, and will help in elucidating the physiological function of each receptor subtype in a wide variety of human systems. ..
  7. Han F, Lin L, Li J, Aran A, Dong S, An P, et al. TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy. Sleep Med. 2012;13:269-72 pubmed publisher
    ..Our aim was to study whether these polymorphisms are associated with narcolepsy and its clinical characteristics in Chinese patients with narcolepsy...
  8. Duhant X, Schandene L, Bruyns C, Gonzalez N, Goldman M, Boeynaems J, et al. Extracellular adenine nucleotides inhibit the activation of human CD4+ T lymphocytes. J Immunol. 2002;169:15-21 pubmed
  9. Bourguignon T, Benoist L, Chadet S, Miquelestorena Standley E, Fromont G, Ivanes F, et al. Stimulation of murine P2Y11-like purinoreceptor protects against hypoxia/reoxygenation injury and decreases heart graft rejection lesions. J Thorac Cardiovasc Surg. 2018;: pubmed publisher
    ..Several in vitro studies demonstrated the protective effect of P2Y11-like purinoreceptor stimulation in the context of myocardial ischemia/reperfusion...

More Information


  1. Danino O, Grossman S, Fischer B. ATP-γ-S-(α,β-CH2) protects against oxidative stress and amyloid beta toxicity in neuronal culture. Biochem Biophys Res Commun. 2015;460:446-50 pubmed publisher
    ..by ecto-nucleotidases such as, NPPs and TNAP, and was found to be ∼7-fold more potent agonist than ATP at P2Y11 receptor...
  2. Liñán Rico A, Wunderlich J, Grants I, Frankel W, Xue J, Williams K, et al. Purinergic autocrine regulation of mechanosensitivity and serotonin release in a human EC model: ATP-gated P2X3 channels in EC are downregulated in ulcerative colitis. Inflamm Bowel Dis. 2013;19:2366-79 pubmed publisher
    ..2% of 5-HThECs. Human mucosa and BON expressed P2X1, P2X3, P2X4, P2X5, P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, and P2Y12R-messenger RNA transcripts...
  3. Delville M, Sigdel T, Wei C, Li J, Hsieh S, Fornoni A, et al. A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation. Sci Transl Med. 2014;6:256ra136 pubmed publisher
    ..Human trials of anti-CD40 therapies are warranted to evaluate their efficacy for preventing rFSGS and improving graft survival. ..
  4. Helenius M, Vattulainen S, Orcholski M, Aho J, Komulainen A, Taimen P, et al. Suppression of endothelial CD39/ENTPD1 is associated with pulmonary vascular remodeling in pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2015;308:L1046-57 pubmed publisher
    ..we also identified that the ATP receptor P2Y11 is essential for ATP-mediated EC survival...
  5. Holm A, Lin L, Faraco J, Mostafavi S, Battle A, Zhu X, et al. EIF3G is associated with narcolepsy across ethnicities. Eur J Hum Genet. 2015;23:1573-80 pubmed publisher
    ..EIF3G is located in the narcolepsy risk locus and EIF3G expression correlates with PPAN and P2RY11 expression. This suggests shared regulatory mechanisms that might be affected by the polymorphism and are of relevance to narcolepsy. ..
  6. Ng P, McIntosh K, Hargrave G, Ho K, Paul A, Plevin R. Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells. Cell Signal. 2018;51:59-71 pubmed publisher
    ..Collectively, these studies indicate the potential for activation of purinergic receptors to protect the endothelium from inflammatory driven JNK activation and may be a new target for inflammatory disease therapy. ..
  7. Barragán Iglesias P, Mendoza Garcés L, Pineda Farias J, Solano Olivares V, Rodríguez Silverio J, Flores Murrieta F, et al. Participation of peripheral P2Y1, P2Y6 and P2Y11 receptors in formalin-induced inflammatory pain in rats. Pharmacol Biochem Behav. 2015;128:23-32 pubmed publisher
    Metabotropic P2Y receptors subfamily consists of eight functional mammalian receptors. Specifically, P2Y1, P2Y6 and P2Y11 receptors have been described in the sensory nervous system, but their participation, at peripheral level, in ..
  8. Lefort C, Benoist L, Chadet S, Piollet M, Heraud A, Babuty D, et al. Stimulation of P2Y11 receptor modulates cardiac fibroblasts secretome toward immunomodulatory and protective roles after Hypoxia/Reoxygenation injury. J Mol Cell Cardiol. 2018;121:212-222 pubmed publisher
    ..g. ATP, leading to purinergic receptors activation. P2Y11 receptor (P2Y11R) is an ATP-sensitive GPCR playing an immunomodulatory role in human dendritic cells (DC)...
  9. Martins J, Silva A, Ferreira I, Goncalo M, Custódio J, Lopes M, et al. Adenosine diphosphate involvement in THP-1 maturation triggered by the contact allergen 1-fluoro-2,4-dinitrobenzene. Toxicol Res (Camb). 2016;5:1512-1521 pubmed publisher
    ..purinergic signaling inhibition, and that the transcription of the purinergic metabotropic receptors P2Y2 and P2Y11 is modulated by the sensitizer...
  10. Jacobson K, Paoletta S, KATRITCH V, Wu B, Gao Z, Zhao Q, et al. Nucleotides Acting at P2Y Receptors: Connecting Structure and Function. Mol Pharmacol. 2015;88:220-30 pubmed publisher
    ..The human P2YRs are fully activated by ATP (P2Y2 and P2Y11), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2 and P2Y4), UDP (P2Y6 and P2Y14), and UDP glucose (P2Y14)...
  11. Azimi I, Beilby H, Davis F, Marcial D, Kenny P, Thompson E, et al. Altered purinergic receptor-Ca²⁺ signaling associated with hypoxia-induced epithelial-mesenchymal transition in breast cancer cells. Mol Oncol. 2016;10:166-78 pubmed publisher
    ..P2X4, P2X5, P2X7, P2Y1 and P2Y11 mRNAs decreased with hypoxia, whereas P2Y6 mRNA increased...
  12. Kawano A, Kadomatsu R, Ono M, Kojima S, Tsukimoto M, Sakamoto H. Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors. PLoS ONE. 2015;10:e0127919 pubmed publisher
    ..was increased after UVA irradiation, and this increase was inhibited by ecto-nucleotidase or by antagonists of P2Y11 or P2Y13 receptor...
  13. Avanzato D, Genova T, Fiorio Pla A, Bernardini M, Bianco S, Bussolati B, et al. Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling. Sci Rep. 2016;6:32602 pubmed publisher
    ..In conclusion, we have identified a purinergic pathway selectively acting as an antiangiogenic and normalizing signal for human tumor-derived vascular endothelium. ..
  14. Silber M. Autoimmune sleep disorders. Handb Clin Neurol. 2016;133:317-26 pubmed publisher
    ..antigen (HLA) DQB1*06:02 haplotype and polymorphisms in the T-cell receptor alpha locus and purinergic receptor P2Y11 genes...
  15. Song S, Jacobson K, McDermott K, Reddy S, Cress A, Tang H, et al. ATP promotes cell survival via regulation of cytosolic [Ca2+] and Bcl-2/Bax ratio in lung cancer cells. Am J Physiol Cell Physiol. 2016;310:C99-114 pubmed publisher
    ..The distribution of P2X (P2X1-7) and P2Y (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11) receptors was different between lung cancer cells and normal cells...
  16. Dreisig K, Degn M, Sund L, Hadaczek P, Samaranch L, San Sebastián W, et al. Validation of antibodies for neuroanatomical localization of the P2Y11 receptor in macaque brain. J Chem Neuroanat. 2016;78:25-33 pubmed publisher
    ..Hence, the neuroanatomical localization of the P2Y11 receptor remains undetermined due to the lack of specific P2Y11 antibodies for brain immunohistochemistry. ..
  17. Ono Y, Saitow F, Konishi S. Differential Modulation of GABAA Receptors Underlies Postsynaptic Depolarization- and Purinoceptor-Mediated Enhancement of Cerebellar Inhibitory Transmission: A Non-Stationary Fluctuation Analysis Study. PLoS ONE. 2016;11:e0150636 pubmed publisher
    ..of the channel conductance by stimulating adenylyl cyclase-PKA signaling cascade, possibly via activation of P2Y11 purinoceptor...
  18. Xu P, Feng X, Luan H, Wang J, Ge R, Li Z, et al. Current knowledge on the nucleotide agonists for the P2Y2 receptor. Bioorg Med Chem. 2018;26:366-375 pubmed publisher
    ..There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14)...
  19. Dreisig K, Kornum B. A critical look at the function of the P2Y11 receptor. Purinergic Signal. 2016;12:427-37 pubmed publisher
    The P2Y11 receptor is a member of the purinergic receptor family...
  20. Certal M, Vinhas A, Pinheiro A, Ferreirinha F, Barros Barbosa A, Silva I, et al. Calcium signaling and the novel anti-proliferative effect of the UTP-sensitive P2Y11 receptor in rat cardiac myofibroblasts. Cell Calcium. 2015;58:518-33 pubmed publisher
    ..response to UTP was attenuated respectively by P2Y4 blockers, like reactive blue-2 and suramin, and by the P2Y11 antagonist, NF340...
  21. van der Weyden L, Conigrave A, Morris M. Signal transduction and white cell maturation via extracellular ATP and the P2Y11 receptor. Immunol Cell Biol. 2000;78:369-74 pubmed
    ..In 1997, a novel ATP-selective P2Y receptor, P2Y11, was cloned and shown to be linked to both cAMP and Ca2+ signalling pathways...
  22. Khalid M, Brisson L, Tariq M, Hao Y, Guibon R, Fromont G, et al. Carcinoma-specific expression of P2Y11 receptor and its contribution in ATP-induced purinergic signalling and cell migration in human hepatocellular carcinoma cells. Oncotarget. 2017;8:37278-37290 pubmed publisher
    ..NF546, a P2Y11 receptor agonist was equally effective in inducing an increase in the [Ca2+]i...
  23. Kennedy C. P2Y11 Receptors: Properties, Distribution and Functions. Adv Exp Med Biol. 2017;1051:107-122 pubmed publisher
    ..Thus proposed potential therapeutic applications relate, in the main, to modulation of acute and chronic inflammatory responses. ..
  24. Fruscione F, Scarfi S, Ferraris C, Bruzzone S, Benvenuto F, Guida L, et al. Regulation of human mesenchymal stem cell functions by an autocrine loop involving NAD+ release and P2Y11-mediated signaling. Stem Cells Dev. 2011;20:1183-98 pubmed publisher
    ..These findings suggest a potential beneficial role of NAD(+)(e) in modulating MSC functions relevant to MSC-based cell therapies. ..
  25. Gorini S, Callegari G, Romagnoli G, Mammi C, Mavilio D, Rosano G, et al. ATP secreted by endothelial cells blocks CX?CL 1-elicited natural killer cell chemotaxis and cytotoxicity via P2Y?? receptor activation. Blood. 2010;116:4492-500 pubmed publisher
    ..These findings point out the P2Y??R as a potential target for pharmacologic intervention aimed at reducing NK-mediated vascular injury. ..
  26. Han F, Faraco J, Dong X, Ollila H, Lin L, Li J, et al. Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic. PLoS Genet. 2013;9:e1003880 pubmed publisher
  27. Zylberg J, Ecke D, Fischer B, Reiser G. Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysis. Biochem J. 2007;405:277-86 pubmed
    The P2Y11-R (P2Y11 receptor) is a less explored drug target. We computed an hP2Y11-R (human P2Y11) homology model with two templates, bovine-rhodopsin (2.6 A resolution; 1 A=0.1 nm) and a hP2Y1-ATP complex model...
  28. Moreschi I, Bruzzone S, Nicholas R, Fruscione F, Sturla L, Benvenuto F, et al. Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes. J Biol Chem. 2006;281:31419-29 pubmed
    ..These results demonstrate that beta-NAD(e)+ is an agonist of the P2Y(11) purinoceptor and that P2Y(11) is the endogenous receptor in granulocytes mediating the sustained [Ca2+]i increase responsible for their functional activation. ..
  29. Ishimaru M, Tsukimoto M, Harada H, Kojima S. Involvement of P2Y?? receptor in IFN-?-induced IL-6 production in human keratinocytes. Eur J Pharmacol. 2013;703:67-73 pubmed publisher
    ..A non-selective antagonist of P2Y receptors (suramin), a selective P2Y11 receptor antagonist (NF157), ecto-nucleotidase (apyrase), and a soluble adenylate cyclase inhibitor (KH7) all ..
  30. Ecke D, Hanck T, Tulapurkar M, Schafer R, Kassack M, Stricker R, et al. Hetero-oligomerization of the P2Y11 receptor with the P2Y1 receptor controls the internalization and ligand selectivity of the P2Y11 receptor. Biochem J. 2008;409:107-16 pubmed
    ..These receptors, P2Y1 and P2Y11, were found to associate together when co-expressed in HEK293 cells...
  31. Higgins G, Buchanan P, Perriere M, Al Alawi M, Costello R, Verriere V, et al. Activation of P2RY11 and ATP release by lipoxin A4 restores the airway surface liquid layer and epithelial repair in cystic fibrosis. Am J Respir Cell Mol Biol. 2014;51:178-90 pubmed publisher
    ..Taken together, our results provide evidence for a novel role of LXA4 in stimulating apical ATP secretion via Pannexin-1 channels and P2RY11 purinoreceptors activation leading to an ASL height increase and epithelial repair. ..
  32. Bornø A, Ploug T, Bune L, Rosenmeier J, Thaning P. Purinergic receptors expressed in human skeletal muscle fibres. Purinergic Signal. 2012;8:255-64 pubmed publisher
  33. Sakaki H, Tsukimoto M, Harada H, Moriyama Y, Kojima S. Autocrine regulation of macrophage activation via exocytosis of ATP and activation of P2Y11 receptor. PLoS ONE. 2013;8:e59778 pubmed publisher
    ..We show here that ATP release via exocytosis, followed by activation of P2Y11 receptor, is a major pathway of the macrophage activation, leading to release of cytokines...
  34. Dănilă M, Privistirescu A, Duicu O, Raţiu C, Angoulvant D, Muntean D, et al. The effect of purinergic signaling via the P2Y11 receptor on vascular function in a rat model of acute inflammation. Mol Cell Biochem. 2017;431:37-44 pubmed publisher
  35. King B, Townsend Nicholson A. Involvement of P2Y1 and P2Y11 purinoceptors in parasympathetic inhibition of colonic smooth muscle. J Pharmacol Exp Ther. 2008;324:1055-63 pubmed
    ..These P2Y receptor subtypes, plus neuronal P2X receptors, may explain the phenomenon of parasympathetic inhibition first described by Langley (1898). ..
  36. Peng H, Hao Y, Mousawi F, Roger S, Li J, Sim J, et al. Purinergic and Store-Operated Ca(2+) Signaling Mechanisms in Mesenchymal Stem Cells and Their Roles in ATP-Induced Stimulation of Cell Migration. Stem Cells. 2016;34:2102-14 pubmed publisher
    ..of mRNA transcripts and interrogation of agonist-induced increases in the [Ca(2+) ]c support that P2X7, P2Y1 , and P2Y11 receptors participate in ATP-induced Ca(2+) signaling...
  37. Haas M, Shaaban A, Reiser G. Alanine-(87)-threonine polymorphism impairs signaling and internalization of the human P2Y11 receptor, when co-expressed with the P2Y1 receptor. J Neurochem. 2014;129:602-13 pubmed publisher
    The P2Y11 nucleotide receptor detects high extracellular ATP concentrations...
  38. Degn M, Dauvilliers Y, Dreisig K, Lopez R, Pfister C, Pradervand S, et al. Rare missense mutations in P2RY11 in narcolepsy with cataplexy. Brain. 2017;140:1657-1668 pubmed publisher
    ..is unknown how these genetic variants affect narcolepsy pathogenesis and whether the effect is directly related to P2Y11 signalling or EIF3G function...
  39. Chadet S, Ivanes F, Benoist L, Salmon Gandonnière C, Guibon R, Velge Roussel F, et al. Hypoxia/Reoxygenation Inhibits P2Y11 Receptor Expression and Its Immunosuppressive Activity in Human Dendritic Cells. J Immunol. 2015;195:651-60 pubmed publisher
    ..Additionally, we demonstrated that the time-dependent downregulation of P2Y11R by hypoxia orientates DCs toward a proinflammatory phenotype that may be involved in post-I/R injuries as observed after organ transplantation. ..
  40. Zuccarini M, Giuliani P, Buccella S, Di Liberto V, Mudo G, Belluardo N, et al. Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells. Purinergic Signal. 2017;13:429-442 pubmed publisher
    ..Furthermore, we showed that A1, A2A, P2Y1, P2Y11, and P2X7 purine receptor agonists modulated the TGF-β1-induced EMT through the involvement of PKA and/or MAPK/..
  41. Moreschi I, Bruzzone S, Bodrato N, Usai C, Guida L, Nicholas R, et al. NAADP+ is an agonist of the human P2Y11 purinergic receptor. Cell Calcium. 2008;43:344-55 pubmed
    ..Moreschi, S. Bruzzone, R.A. Nicholas, et al., Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes, J. Biol. Chem. 281 (2006) 31419-31429]...
  42. Lugo Garcia L, Nadal B, Gomis R, Petit P, Gross R, Lajoix A. Human pancreatic islets express the purinergic P2Y11 and P2Y12 receptors. Horm Metab Res. 2008;40:827-30 pubmed publisher
  43. von Kügelgen I, Hoffmann K. Pharmacology and structure of P2Y receptors. Neuropharmacology. 2016;104:50-61 pubmed publisher
    ..There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14)...