P2X7

Summary

Gene Symbol: P2X7
Description: purinergic receptor P2X 7
Alias: P2X7, P2X purinoceptor 7, ATP receptor, P2X7 receptor, P2Z receptor, purinergic receptor P2X, ligand gated ion channel, 7, purinergic receptor P2X7 variant A
Species: human
Products:     P2X7

Top Publications

  1. Hejjas K, Szekely A, Domotor E, Halmai Z, Balogh G, Schilling B, et al. Association between depression and the Gln460Arg polymorphism of P2RX7 gene: a dimensional approach. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:295-9 pubmed publisher
    The P2RX7 gene (coding for P2X7 purinergic receptor) has been suggested as a novel candidate gene for major depressive disorder (MDD) and bipolar disorder (BPD)...
  2. Palomino Doza J, Rahman T, Avery P, Mayosi B, Farrall M, Watkins H, et al. Ambulatory blood pressure is associated with polymorphic variation in P2X receptor genes. Hypertension. 2008;52:980-5 pubmed publisher
    ..a proband with hypertension to investigate the relationship between common genetic variation in the P2X4, P2X6, and P2X7 genes and ambulatory blood pressure...
  3. Wesselius A, Bours M, Henriksen Z, Syberg S, Petersen S, Schwarz P, et al. Association of P2X7 receptor polymorphisms with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients. Osteoporos Int. 2013;24:1235-46 pubmed publisher
    The P2X7 receptor is thought to be involved in bone physiology in a pro-osteogenic manner. Therefore, we examined associations between genetic variations in the P2X7 receptor gene and bone mineral density (BMD)...
  4. Backlund L, Nikamo P, Hukic D, Ek I, Traskman Bendz L, Landen M, et al. Cognitive manic symptoms associated with the P2RX7 gene in bipolar disorder. Bipolar Disord. 2011;13:500-8 pubmed publisher
    ..016). ? There is an association between specific symptoms of bipolar disorder and the P2RX7 gene. This finding may open up new approaches to elucidating the neurobiology behind bipolar symptoms. ..
  5. Erhardt A, Lucae S, Unschuld P, Ising M, Kern N, Salyakina D, et al. Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders. J Affect Disord. 2007;101:159-68 pubmed
    ..The specific contribution of the herein reported gene polymorphisms to the clinical condition is still unclear and warrants further analysis. ..
  6. Bahari G, Hashemi M, Taheri M, Naderi M, Moazeni Roodi A, Kouhpayeh H, et al. Association of P2X7 gene polymorphisms with susceptibility to pulmonary tuberculosis in Zahedan, Southeast Iran. Genet Mol Res. 2013;12:160-6 pubmed publisher
    Susceptibility to tuberculosis may be influenced by variations in human genes. The P2X7 receptor is an ATP-gated cation channel expressed in immune cells, and it influences the release of proinflammatory cytokines from monocytes and ..
  7. Green E, Grozeva D, Raybould R, Elvidge G, Macgregor S, Craig I, et al. P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:1063-9 pubmed publisher
    ..Our data do not provide support for rs2230912 or the other polymorphisms studied within the P2RX7 locus, being involved in susceptibility to mood disorders. ..
  8. Gu B, Saunders B, Jursik C, Wiley J. The P2X7-nonmuscle myosin membrane complex regulates phagocytosis of nonopsonized particles and bacteria by a pathway attenuated by extracellular ATP. Blood. 2010;115:1621-31 pubmed publisher
    ..The inhibitory effect of ATP on particle uptake by the macrophage is regulated by the P2X(7) receptor and defines this phagocytic pathway. ..
  9. Grigoroiu Serbanescu M, Herms S, Mühleisen T, Georgi A, Diaconu C, Strohmaier J, et al. Variation in P2RX7 candidate gene (rs2230912) is not associated with bipolar I disorder and unipolar major depression in four European samples. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:1017-21 pubmed publisher
    ..Additional studies are needed to clarify the potential involvement of P2RX7 and of SNP rs2230912 in the etiology of major affective disorders. ..

More Information

Publications120 found, 100 shown here

  1. Xiao J, Sun L, Yan H, Jiao W, Miao Q, Feng W, et al. Metaanalysis of P2X7 gene polymorphisms and tuberculosis susceptibility. FEMS Immunol Med Microbiol. 2010;60:165-70 pubmed publisher
    Although many case-control studies have investigated the association between P2X7 gene polymorphisms and tuberculosis susceptibility, the interpretation of these data has been difficult due to limited power...
  2. Müller T, Vieira R, Grimm M, Dürk T, Cicko S, Zeiser R, et al. A potential role for P2X7R in allergic airway inflammation in mice and humans. Am J Respir Cell Mol Biol. 2011;44:456-64 pubmed publisher
    ..Our data suggest that targeting P2X?R on hematopoietic cells (e.g., DCs or eosinophils) might be a new therapeutic option for the treatment of asthma...
  3. Ben Selma W, Ben Kahla I, Boukadida J, Harizi H. Contribution of the P2X7 1513A/C loss-of-function polymorphism to extrapulmonary tuberculosis susceptibility in Tunisian populations. FEMS Immunol Med Microbiol. 2011;63:65-72 pubmed publisher
    The P2X7 receptor has been found to be linked to an increased risk for tuberculosis in some populations. In this study, we investigate whether the P2X7 receptor plays a role in increasing susceptibility to tuberculosis in Tunisia...
  4. Gomez Villafuertes R, del Puerto A, Diaz Hernandez M, Bustillo D, Diaz Hernandez J, Huerta P, et al. Ca2+/calmodulin-dependent kinase II signalling cascade mediates P2X7 receptor-dependent inhibition of neuritogenesis in neuroblastoma cells. FEBS J. 2009;276:5307-25 pubmed publisher
    ..Previously, we have reported that P2X7 receptor inhibition promotes axonal growth and branching in cultured hippocampal neurons...
  5. Verhoef P, Estacion M, Schilling W, Dubyak G. P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release. J Immunol. 2003;170:5728-38 pubmed
    ..Similar image analyses in human embryonic kidney 293 cells expressing recombinant P2X7R (HEK-P2X7) permitted comparison of P2X7R-dependent effects in macrophage vs nonmacrophage backgrounds...
  6. Adinolfi E, Cirillo M, Woltersdorf R, Falzoni S, Chiozzi P, Pellegatti P, et al. Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor. FASEB J. 2010;24:3393-404 pubmed publisher
    ..P2X7B is widely expressed in several human tissues, modulates P2X7A functions, participates in the control of cell growth, and may help understand the role of the P2X7 receptor in the control of normal and cancer cell proliferation.
  7. Bradley H, Baldwin J, Goli G, Johnson B, Zou J, Sivaprasadarao A, et al. Residues 155 and 348 contribute to the determination of P2X7 receptor function via distinct mechanisms revealed by single-nucleotide polymorphisms. J Biol Chem. 2011;286:8176-87 pubmed publisher
    ..Such interpretations are consistent with the locations of the residues in the structural model of the hP2X(7) receptor. ..
  8. Swartz T, Esposito A, Durham N, Hartmann B, Chen B. P2X-selective purinergic antagonists are strong inhibitors of HIV-1 fusion during both cell-to-cell and cell-free infection. J Virol. 2014;88:11504-15 pubmed publisher
    ..Clinical studies on these drugs for other inflammatory indications suggest that they are safe, and thus, if developed for use as anti-HIV agents, they could reduce both HIV replication and HIV-related inflammation. ..
  9. Sambasivan V, Murthy K, Reddy R, Vijayalakshimi V, Hasan Q. P2X7 gene polymorphisms and risk assessment for pulmonary tuberculosis in Asian Indians. Dis Markers. 2010;28:43-8 pubmed publisher
    ..Extracellular ATP induces macrophage bactericidal activity through activation of the purinergic P2X7 receptor. This case- control study assesses the association of -762 T/C, 1513A/C and 1729T/A P2X7 polymorphisms in ..
  10. Witting A, Walter L, Wacker J, Moller T, Stella N. P2X7 receptors control 2-arachidonoylglycerol production by microglial cells. Proc Natl Acad Sci U S A. 2004;101:3214-9 pubmed
  11. Xiao J, Sun L, Jiao W, Li Z, Zhao S, Li H, et al. Lack of association between polymorphisms in the P2X7 gene and tuberculosis in a Chinese Han population. FEMS Immunol Med Microbiol. 2009;55:107-11 pubmed publisher
    ..that genetic factors may affect the susceptibility of a population to tuberculosis, and it has been found that P2X7 is linked to an increased risk for tuberculosis in some West African, Southeast Asian, North American, and North ..
  12. Hewinson J, Moore S, Glover C, Watts A, Mackenzie A. A key role for redox signaling in rapid P2X7 receptor-induced IL-1 beta processing in human monocytes. J Immunol. 2008;180:8410-20 pubmed
    ..These data demonstrate that signaling via NADPH oxidase activity is fundamental for the processing of mature IL-1beta induced by P2X(7)R stimulation. ..
  13. Jørgensen N, Husted L, Skarratt K, Stokes L, Tofteng C, Kvist T, et al. Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fractures. Eur J Hum Genet. 2012;20:675-81 pubmed publisher
    The purinergic P2X7 receptor has a major role in the regulation of osteoblast and osteoclast activity and changes in receptor function may therefore affect bone mass in vivo...
  14. Nuckel H, Frey U, Dürig J, Duhrsen U, Siffert W. 1513A/C polymorphism in the P2X7 receptor gene in chronic lymphocytic leukemia: absence of correlation with clinical outcome. Eur J Haematol. 2004;72:259-63 pubmed
    Purinergic P2X7 receptors are ligand-gated cation channels expressed on the cells of the immune and hemopoietic system which have been shown to mediate the ATP-induced apoptotic death of monocytes, macrophages and lymphocytes...
  15. Pelegrin P, Surprenant A. Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J. 2006;25:5071-82 pubmed
  16. Al Shukaili A, Al Kaabi J, Hassan B. A comparative study of interleukin-1beta production and p2x7 expression after ATP stimulation by peripheral blood mononuclear cells isolated from rheumatoid arthritis patients and normal healthy controls. Inflammation. 2008;31:84-90 pubmed
    ..These data suggest that RA patient mononuclear cells are more sensitive to ATP stimulation than healthy individuals perhaps due to genetic polymorphism in the P2X(7) gene. ..
  17. Lavebratt C, Aberg E, Sjöholm L, Forsell Y. Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort. J Affect Disord. 2010;125:249-55 pubmed publisher
    ..P2RX7:2230912 and CACNA1C:rs1006737 did not have a large or moderate-size effect on depression risk. Further studies are required to estimate the significance of these findings. ..
  18. Zhang L, Ibbotson R, Orchard J, Gardiner A, Seear R, Chase A, et al. P2X7 polymorphism and chronic lymphocytic leukaemia: lack of correlation with incidence, survival and abnormalities of chromosome 12. Leukemia. 2003;17:2097-100 pubmed
    The P2X7 receptor, a plasma membrane ATP-gated ion channel that plays a role in lymphocyte apoptosis, has been suggested as an important contributory factor to the pathogenesis of chronic lymphocytic leukaemia (CLL)...
  19. Hansen R, Nielsen C, Nasser A, Thomsen S, Eghorn L, Pham Y, et al. P2X7 receptor-deficient mice are susceptible to bone cancer pain. Pain. 2011;152:1766-76 pubmed publisher
    The purinergic P2X7 receptor is implicated in both neuropathic and inflammatory pain, and has been suggested as a possible target in pain treatment. However, the specific role of the P2X7 receptor in bone cancer pain is unknown...
  20. Hazleton J, Berman J, Eugenin E. Purinergic receptors are required for HIV-1 infection of primary human macrophages. J Immunol. 2012;188:4488-95 pubmed publisher
    ..Our data implicate a novel role for a family of host proteins in HIV replication in macrophages and suggest new therapeutic targets to reduce the devastating consequences of HIV infection and AIDS. ..
  21. Foster J, Carter E, Kilty I, Mackenzie A, Ward S. Mitochondrial superoxide generation enhances P2X7R-mediated loss of cell surface CD62L on naive human CD4+ T lymphocytes. J Immunol. 2013;190:1551-9 pubmed publisher
    ..The clearance of apoptotic cells may therefore be enhanced by this mechanism which requires functional P2X7R expression. ..
  22. Adriouch S, Bannas P, Schwarz N, Fliegert R, Guse A, Seman M, et al. ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site. FASEB J. 2008;22:861-9 pubmed
    ..b>P2X7, an ATP-gated ion channel with important roles in inflammation and cell death, in contrast, is activated by ADP-..
  23. Madec S, Rossi C, Chiarugi M, Santini E, Salvati A, Ferrannini E, et al. Adipocyte P2X7 receptors expression: a role in modulating inflammatory response in subjects with metabolic syndrome?. Atherosclerosis. 2011;219:552-8 pubmed publisher
    ..Adipocytes from MS patients show an enhanced P2X(7)R expression, which might contribute to the subclinical inflammatory status characterizing these patients and conferring them an increased CV risk. ..
  24. Lees M, Fuller S, McLeod R, Boulter N, Miller C, Zakrzewski A, et al. P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages. J Immunol. 2010;184:7040-6 pubmed publisher
    ..gondii as effectively as macrophages from wild-type mice. We show that P2X7R-mediated T. gondii killing occurs in parallel with host cell apoptosis and is independent of NO production. ..
  25. Li C, Campbell S, Kumararatne D, Bellamy R, Ruwende C, McAdam K, et al. Association of a polymorphism in the P2X7 gene with tuberculosis in a Gambian population. J Infect Dis. 2002;186:1458-62 pubmed
    ..70; 95% confidence interval [CI], 0.54-0.89; P=.003; OR for CC genotype, 0.545; 95% CI, 0.318-0.934; P=.027). This association supports a role for ATP/P2X(7)-mediated host regulation of Mycobacterium tuberculosis infection. ..
  26. Chessell I, Hatcher J, Bountra C, Michel A, Hughes J, Green P, et al. Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain. 2005;114:386-96 pubmed
    ..Drugs which block this target may have the potential to deliver broad-spectrum analgesia. ..
  27. Ohlendorff S, Tofteng C, Jensen J, Petersen S, Civitelli R, Fenger M, et al. Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatment. Pharmacogenet Genomics. 2007;17:555-67 pubmed
    ..The aim of this study was to determine the presence of polymorphisms in exon 13 of the P2X7 gene and the association with osteoclast apoptosis in vitro and bone status in vivo...
  28. Sharma S, Kumar V, Khosla R, Kajal N, Sarin B, Sehajpal P. Association of P2X7 receptor +1513 (A-->C) polymorphism with tuberculosis in a Punjabi population. Int J Tuberc Lung Dis. 2010;14:1159-63 pubmed
    ..002). The +1513C allele is a risk factor for the development of TB in the North Indian Punjabi population. ..
  29. Gu B, Sluyter R, Skarratt K, Shemon A, Dao Ung L, Fuller S, et al. An Arg307 to Gln polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptor. J Biol Chem. 2004;279:31287-95 pubmed
  30. Hill L, Gavala M, Lenertz L, Bertics P. Extracellular ATP may contribute to tissue repair by rapidly stimulating purinergic receptor X7-dependent vascular endothelial growth factor release from primary human monocytes. J Immunol. 2010;185:3028-34 pubmed publisher
    ..This previously unrecognized action of P2RX7 suggests that it may not only participate in inflammation and cell death, but that it is also likely to be important in the control of angiogenesis and wound repair. ..
  31. García Hernández M, Portales Cervantes L, Cortez Espinosa N, Vargas Morales J, Fritche Salazar J, Rivera López E, et al. Expression and function of P2X(7) receptor and CD39/Entpd1 in patients with type 2 diabetes and their association with biochemical parameters. Cell Immunol. 2011;269:135-43 pubmed publisher
    ..Therefore, CD39(+) cells could have a balancing regulatory role in the inflammatory process observed in patients with T2D. ..
  32. Al Shukaili A, Al Kaabi J, Hassan B, Al Araimi T, Al Tobi M, Al Kindi M, et al. P2X7 receptor gene polymorphism analysis in rheumatoid arthritis. Int J Immunogenet. 2011;38:389-96 pubmed publisher
    The P2X7 receptor, a member of the P2X family of nucleotide-gated channels, is predominantly expressed by monocytic cells...
  33. Wiley J, Sluyter R, Gu B, Stokes L, Fuller S. The human P2X7 receptor and its role in innate immunity. Tissue Antigens. 2011;78:321-32 pubmed publisher
    The human P2X7 receptor is a two-transmembrane ionotropic receptor which has a ubiquitous distribution and is most highly expressed on immune cells...
  34. Gartland A, Buckley K, Bowler W, Gallagher J. Blockade of the pore-forming P2X7 receptor inhibits formation of multinucleated human osteoclasts in vitro. Calcif Tissue Int. 2003;73:361-9 pubmed
    ..The ATP-gated P2X7 receptor is a plasma membrane receptor belonging to the family of P2X purinergic receptors...
  35. Adinolfi E, Callegari M, Cirillo M, Pinton P, Giorgi C, Cavagna D, et al. Expression of the P2X7 receptor increases the Ca2+ content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis. J Biol Chem. 2009;284:10120-8 pubmed publisher
    ..e. those observed in response to basal ATP release, has an anti-apoptotic or even growth promoting rather than cytotoxic activity. ..
  36. Cabrini G, Falzoni S, Forchap S, Pellegatti P, Balboni A, Agostini P, et al. A His-155 to Tyr polymorphism confers gain-of-function to the human P2X7 receptor of human leukemic lymphocytes. J Immunol. 2005;175:82-9 pubmed
    ..These data identify the 489C>T as a gain-of-function polymorphism of the P2X(7)R. ..
  37. Feng Y, Li X, Wang L, Zhou L, Gorodeski G. A truncated P2X7 receptor variant (P2X7-j) endogenously expressed in cervical cancer cells antagonizes the full-length P2X7 receptor through hetero-oligomerization. J Biol Chem. 2006;281:17228-37 pubmed
    ..terminus, the second transmembrane domain, and the distal third of the extracellular loop of the full-length P2X7 receptor. The P2X7-j was expressed in the plasma membrane; it showed diminished ligand-binding and channel function ..
  38. Riedel T, Schmalzing G, Markwardt F. Influence of extracellular monovalent cations on pore and gating properties of P2X7 receptor-operated single-channel currents. Biophys J. 2007;93:846-58 pubmed
  39. Tekin D, Kayaalti Z, Dalgic N, Cakir E, Soylemezoglu T, Isin Kutlubay B, et al. Polymorphism in the p2x7 gene increases susceptibility to extrapulmonary tuberculosis in Turkish children. Pediatr Infect Dis J. 2010;29:779-82 pubmed publisher
    The P2X7 gene polymorphisms have been linked to increased risk for pulmonary and extrapulmonary tuberculosis in some populations...
  40. Gu B, Zhang W, Worthington R, Sluyter R, Dao Ung P, Petrou S, et al. A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor. J Biol Chem. 2001;276:11135-42 pubmed
    ..6 versus 35.2%). The data suggest that the glutamic acid at position 496 is required for optimal assembly of the P2X(7) receptor. ..
  41. Rahman O, Sasvari Szekely M, Szekely A, Faludi G, Guttman A, Nemoda Z. Analysis of a polymorphic microRNA target site in the purinergic receptor P2RX7 gene. Electrophoresis. 2010;31:1790-5 pubmed publisher
    ..The developed genotyping method was applied in our depression-related association study. ..
  42. Pupovac A, Stokes L, Sluyter R. CAY10593 inhibits the human P2X7 receptor independently of phospholipase D1 stimulation. Purinergic Signal. 2013;9:609-19 pubmed publisher
    The P2X7 receptor is a trimeric ATP-gated cation channel important in health and disease...
  43. Gartland A, Hipskind R, Gallagher J, Bowler W. Expression of a P2X7 receptor by a subpopulation of human osteoblasts. J Bone Miner Res. 2001;16:846-56 pubmed
    ..In nonskeletal tissue recent attention has focused on one particular P2 receptor, the P2X7 receptor (previously termed P2Z), and its ability to form nonselective aqueous pores in the plasma membrane on ..
  44. Michel A, Ng S, Roman S, Clay W, Dean D, Walter D. Mechanism of action of species-selective P2X(7) receptor antagonists. Br J Pharmacol. 2009;156:1312-25 pubmed publisher
    ..The differential interaction of the two compounds with the receptor suggests there may be more than one allosteric regulatory site on the P2X(7) receptor at which antagonists can bind and affect receptor function. ..
  45. Roger S, Mei Z, Baldwin J, Dong L, Bradley H, Baldwin S, et al. Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions. J Psychiatr Res. 2010;44:347-55 pubmed publisher
    ..These results provide essential knowledge for a better understanding of the relationships between human P2RX7 SNPs and associated pathologies as well as the receptor structure-function relationships. ..
  46. Sorge R, Trang T, Dorfman R, Smith S, Beggs S, Ritchie J, et al. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nat Med. 2012;18:595-9 pubmed publisher
    ..Here we show that variation within the coding sequence of the gene encoding the P2X7 receptor (P2X7R) affects chronic pain sensitivity in both mice and humans...
  47. Wiley J, Dao Ung L, Li C, Shemon A, Gu B, Smart M, et al. An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor. J Biol Chem. 2003;278:17108-13 pubmed
    ..These data identify a second loss-of-function polymorphism within the P2X(7) receptor and show that Ile-568 is critical to the trafficking domain, which we have shown to lie between residues 551 and 581. ..
  48. Stokes L, Fuller S, Sluyter R, Skarratt K, Gu B, Wiley J. Two haplotypes of the P2X(7) receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1beta secretion. FASEB J. 2010;24:2916-27 pubmed publisher
    ..Inheritance of these P2X(7) haplotypes predisposing to increased proinflammatory cytokine secretion may be important in genetic association studies of inflammatory, infectious, and psychiatric disorders. ..
  49. Wesselius A, Bours M, Arts I, Theunisz E, Geusens P, Dagnelie P. The P2X(7) loss-of-function Glu496Ala polymorphism affects ex vivo cytokine release and protects against the cytotoxic effects of high ATP-levels. BMC Immunol. 2012;13:64 pubmed publisher
    ..Blood from n=9 subjects with the Glu496Ala P2X7 SNP (P2X7MUT) and n=7 'wild-type' subjects (no P2X7 SNP; P2X7WT) was used.Addition of ATP (0...
  50. Jelassi B, Anchelin M, Chamouton J, Cayuela M, Clarysse L, Li J, et al. Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors. Carcinogenesis. 2013;34:1487-96 pubmed publisher
    The adenosine 5'-triphosphate (ATP)-gated Ca(2+)-permeable channel P2X7 receptor (P2X7R) is strongly upregulated in many tumors and cancer cells, and has an important role in cancer cell invasion associated with metastases...
  51. Solini A, Chiozzi P, Morelli A, Adinolfi E, Rizzo R, Baricordi O, et al. Enhanced P2X7 activity in human fibroblasts from diabetic patients: a possible pathogenetic mechanism for vascular damage in diabetes. Arterioscler Thromb Vasc Biol. 2004;24:1240-5 pubmed
    We have investigated expression and function of the P2X7 receptor in fibroblasts from healthy subjects and patients with type 2 diabetes. Fibroblasts were isolated from skin biopsies...
  52. Skarratt K, Fuller S, Sluyter R, Dao Ung L, Gu B, Wiley J. A 5' intronic splice site polymorphism leads to a null allele of the P2X7 gene in 1-2% of the Caucasian population. FEBS Lett. 2005;579:2675-8 pubmed
    ..The splice site mutation is an inherited polymorphism and gives rise to a P2X(7) null allele in 1-2% of the Caucasian population. ..
  53. Lucae S, Salyakina D, Barden N, Harvey M, Gagné B, Labbé M, et al. P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder. Hum Mol Genet. 2006;15:2438-45 pubmed
    ..This polymorphism results in an amino acid exchange in the C-terminal cytosolic domain of the P2RX7 channel protein, suggesting that the observed P2RX7 polymorphism might play a causal role in the development of depression. ..
  54. Kim M, Jiang L, Wilson H, North R, Surprenant A. Proteomic and functional evidence for a P2X7 receptor signalling complex. EMBO J. 2001;20:6347-58 pubmed
    P2X receptors are ATP-gated ion channels in the plasma membrane, but activation of the P2X7 receptor also leads to rapid cytoskeletal re-arrangements such as membrane blebbing...
  55. Li X, Qi X, Zhou L, Catera D, Rote N, Potashkin J, et al. Decreased expression of P2X7 in endometrial epithelial pre-cancerous and cancer cells. Gynecol Oncol. 2007;106:233-43 pubmed
    ..Cancerous epithelial cells degrade P2X(7) mRNA by activation of instability domains located at the 3'UTR of the P2X(7). ..
  56. Barberà Cremades M, Baroja Mazo A, Gómez A, Machado F, Di Virgilio F, Pelegrin P. P2X7 receptor-stimulation causes fever via PGE2 and IL-1? release. FASEB J. 2012;26:2951-62 pubmed publisher
    ..Barberà-Cremades, M., Baroja-Mazo, A., Gomez, A. I., Machado, F., Di Virgilio, F., Pelegrín, P. P2X7 receptor-stimulation causes fever via PGE2 and IL-1? release.
  57. Denlinger L, Sommer J, Parker K, Gudipaty L, Fisette P, Watters J, et al. Mutation of a dibasic amino acid motif within the C terminus of the P2X7 nucleotide receptor results in trafficking defects and impaired function. J Immunol. 2003;171:1304-11 pubmed
    ..These data suggest that the lipid interaction motif of the P2X(7) C terminus controls receptor trafficking and modulates channel activity. ..
  58. Cheewatrakoolpong B, Gilchrest H, Anthes J, Greenfeder S. Identification and characterization of splice variants of the human P2X7 ATP channel. Biochem Biophys Res Commun. 2005;332:17-27 pubmed
    The P2X7 channel is a member of the P2X family of ligand-gated ion channels which respond to ATP as the endogenous agonist...
  59. Wiley J, Gu B. A new role for the P2X7 receptor: a scavenger receptor for bacteria and apoptotic cells in the absence of serum and extracellular ATP. Purinergic Signal. 2012;8:579-86 pubmed publisher
    The P2X7 receptor is widely recognized to mediate the proinflammatory effects of extracellular ATP. However this receptor in the absence of ATP may have a function unrelated to inflammation...
  60. Alves L, Bezerra R, Faria R, Ferreira L, da Silva Frutuoso V. Physiological roles and potential therapeutic applications of the P2X7 receptor in inflammation and pain. Molecules. 2013;18:10953-72 pubmed publisher
    The P2X7 receptor (P2X7R) is a nonselective cation channel that is activated by extracellular ATP and triggers the secretion of several proinflammatory substances, such as IL-1β, IL-18, TNF-α, and nitric oxide...
  61. Wilson H, Wilson S, Surprenant A, North R. Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus. J Biol Chem. 2002;277:34017-23 pubmed
    ..These findings suggest that the P2X(7) C-terminal domain associates with EMPs, and this interaction may mediate some aspects of the downstream signaling following P2X(7) receptor activation. ..
  62. Gonnord P, Delarasse C, Auger R, Benihoud K, Prigent M, Cuif M, et al. Palmitoylation of the P2X7 receptor, an ATP-gated channel, controls its expression and association with lipid rafts. FASEB J. 2009;23:795-805 pubmed publisher
    The P2X7 receptor (P2X7R) is an ATP-gated cationic channel expressed by hematopoietic, epithelial, and neuronal cells. Prolonged ATP exposure leads to the formation of a nonselective pore, which can result in cell death...
  63. Gartland A, Skarratt K, Hocking L, Parsons C, Stokes L, Jørgensen N, et al. Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women. Eur J Hum Genet. 2012;20:559-64 pubmed publisher
    The P2X7 receptor gene (P2RX7) is highly polymorphic with five previously described loss-of-function (LOF) single-nucleotide polymorphisms (SNP; c.151+1G>T, c.946G>A, c.1096C>G, c.1513A>C and c...
  64. McHugh S, Roman S, Davis B, Koch A, Pickett A, Richardson J, et al. Effects of genetic variation in the P2RX7 gene on pharmacodynamics of a P2X(7) receptor antagonist: a prospective genotyping approach. Br J Clin Pharmacol. 2012;74:376-80 pubmed publisher
    ..Leukocyte P2X₇ receptors had significantly altered pharmacodynamic responses to a specific antagonist (GSK1370319A), directly related to SNP genotype. ..
  65. Fernando S, Saunders B, Sluyter R, Skarratt K, Wiley J, Britton W. Gene dosage determines the negative effects of polymorphic alleles of the P2X7 receptor on adenosine triphosphate-mediated killing of mycobacteria by human macrophages. J Infect Dis. 2005;192:149-55 pubmed
    Stimulation of the P2X7 purinergic receptor (P2X7) in bacille Calmette-Guerin (BCG)-infected human macrophages with extracellular adenosine triphosphate (ATP) leads to pore formation and killing of mycobacteria...
  66. Raffaghello L, Chiozzi P, Falzoni S, Di Virgilio F, Pistoia V. The P2X7 receptor sustains the growth of human neuroblastoma cells through a substance P-dependent mechanism. Cancer Res. 2006;66:907-14 pubmed
    ..Therefore, neuroblastoma cells seem to have molded P2X(7) function to their advantage in two ways (i.e., by silencing P2X(7) proapoptotic activity and by coupling P2X(7) stimulation to release of locally acting trophic factors). ..
  67. Mishra A, Chintagari N, Guo Y, Weng T, Su L, Liu L. Purinergic P2X7 receptor regulates lung surfactant secretion in a paracrine manner. J Cell Sci. 2011;124:657-68 pubmed publisher
    ..These results suggest that the activation of P2X(7)R increases surfactant secretion by releasing ATP from AEC I and subsequently stimulating P2Y(2) receptors in AEC II. ..
  68. North R. Molecular physiology of P2X receptors. Physiol Rev. 2002;82:1013-67 pubmed
    ..In the last case, P2X7 receptor activation stimulates cytokine release by engaging intracellular signaling pathways.
  69. Taylor J, Han Z. Purinergic receptor functionality is necessary for infection of human hepatocytes by hepatitis delta virus and hepatitis B virus. PLoS ONE. 2010;5:e15784 pubmed publisher
    ..BBG, unlike suramin and PPADS, is known to be more specific for just one purinergic receptor, P2X7. These studies provide the first evidence that purinergic receptor functionality is necessary for virus entry...
  70. Zhang X, Zheng G, Ma X, Yang Y, Li G, Rao Q, et al. Expression of P2X7 in human hematopoietic cell lines and leukemia patients. Leuk Res. 2004;28:1313-22 pubmed
    The P2X7 nucleotide receptor is an adenosine 5'-triphosphate (ATP) -gated ion channel, which is widely expressed in cells of hematopoietic origin and functions as a non-selective cation channel permeable to Na+, Ca2+, etc upon stimulation...
  71. Adinolfi E, Raffaghello L, Giuliani A, Cavazzini L, Capece M, Chiozzi P, et al. Expression of P2X7 receptor increases in vivo tumor growth. Cancer Res. 2012;72:2957-69 pubmed publisher
    The P2X7 receptor is an ATP-gated ion channel known for its cytotoxic activity. However, recent evidence suggests a role for P2X7 in cell proliferation. Here, we found that P2X7 exhibits significant growth-promoting effects in vivo...
  72. Saunders B, Fernando S, Sluyter R, Britton W, Wiley J. A loss-of-function polymorphism in the human P2X7 receptor abolishes ATP-mediated killing of mycobacteria. J Immunol. 2003;171:5442-6 pubmed
    ..We have recently identified a single nucleotide polymorphism in the P2X7 gene (1513A-->C), with 1-2% prevalence in the homozygous state, which codes for a nonfunctional receptor...
  73. Hansen T, Jakobsen K, Fenger M, Nielsen J, Krane K, Fink Jensen A, et al. Variation in the purinergic P2RX(7) receptor gene and schizophrenia. Schizophr Res. 2008;104:146-52 pubmed publisher
    ..The high ethnic and diagnostic homogeneity of the sample adds credibility to this finding. P2XR(7) was not associated with schizophrenia in this study. ..
  74. Furlan Freguia C, Marchese P, Gruber A, Ruggeri Z, Ruf W. P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice. J Clin Invest. 2011;121:2932-44 pubmed publisher
    ..in mouse myeloid cells, ATP-triggered signaling through purinergic receptor P2X, ligand-gated ion channel, 7 (P2X7 receptor; encoded by P2rx7) induced activation (decryption) of TF procoagulant activity and promoted release of TF+ MPs ..
  75. Adinolfi E, Callegari M, Ferrari D, Bolognesi C, Minelli M, Wieckowski M, et al. Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth. Mol Biol Cell. 2005;16:3260-72 pubmed
    b>P2X7 is a bifunctional receptor (P2X7R) for extracellular ATP that, depending on the level of activation, forms a cation-selective channel or a large conductance nonselective pore...
  76. Solini A, Cuccato S, Ferrari D, Santini E, Gulinelli S, Callegari M, et al. Increased P2X7 receptor expression and function in thyroid papillary cancer: a new potential marker of the disease?. Endocrinology. 2008;149:389-96 pubmed
    ..These data suggest that an enhanced P2X(7)R function might be a feature of human thyroid cancer. ..
  77. Soronen P, Mantere O, Melartin T, Suominen K, Vuorilehto M, Rytsälä H, et al. P2RX7 gene is associated consistently with mood disorders and predicts clinical outcome in three clinical cohorts. Am J Med Genet B Neuropsychiatr Genet. 2011;156B:435-47 pubmed publisher
    ..The same risk alleles resulted in clinically significant differences in outcome of patients with major depressive and bipolar disorder. ..
  78. Yip L, Woehrle T, Corriden R, Hirsh M, Chen Y, Inoue Y, et al. Autocrine regulation of T-cell activation by ATP release and P2X7 receptors. FASEB J. 2009;23:1685-93 pubmed publisher
    ..We conclude that ATP release and autocrine, positive feedback through P2X(7) receptors is required for the effective activation of T cells. ..
  79. Wareham K, Vial C, Wykes R, Bradding P, Seward E. Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells. Br J Pharmacol. 2009;157:1215-24 pubmed publisher
    ..RT-PCR revealed P2X1, P2X4 and P2X7 transcripts in both cell types; mRNA for P2X6 was also detected in LAD2 cells...
  80. Roger S, Gillet L, Baroja Mazo A, Surprenant A, Pelegrin P. C-terminal calmodulin-binding motif differentially controls human and rat P2X7 receptor current facilitation. J Biol Chem. 2010;285:17514-24 pubmed publisher
    ..The absence of Ca(2+)-dependent facilitation at the human P2X(7)R may represent a protective adaptation of the innate immune response in which P2X(7)R plays significant roles. ..
  81. Solini A, Menini S, Rossi C, Ricci C, Santini E, Blasetti Fantauzzi C, et al. The purinergic 2X7 receptor participates in renal inflammation and injury induced by high-fat diet: possible role of NLRP3 inflammasome activation. J Pathol. 2013;231:342-53 pubmed publisher
    ..The purinergic 2X7 receptor (P2X7 R) and the nucleotide-binding and oligomerization domain-like receptor containing a pyrin domain 3 (NLRP3) ..
  82. Sluyter R, Shemon A, Wiley J. Glu496 to Ala polymorphism in the P2X7 receptor impairs ATP-induced IL-1 beta release from human monocytes. J Immunol. 2004;172:3399-405 pubmed
    ..biologically inactive IL-1beta that can be processed and released by subsequent activation of the P2X7 receptor by extracellular ATP...
  83. Denlinger L, Angelini G, Schell K, Green D, Guadarrama A, Prabhu U, et al. Detection of human P2X7 nucleotide receptor polymorphisms by a novel monocyte pore assay predictive of alterations in lipopolysaccharide-induced cytokine production. J Immunol. 2005;174:4424-31 pubmed
  84. Cesaro A, Brest P, Hofman V, Hebuterne X, Wildman S, Ferrua B, et al. Amplification loop of the inflammatory process is induced by P2X7R activation in intestinal epithelial cells in response to neutrophil transepithelial migration. Am J Physiol Gastrointest Liver Physiol. 2010;299:G32-42 pubmed publisher
    ..Overall, these changes in P2X(7)R function may serve to tailor the intensity of the inflammatory response and to prevent IL-1beta overproduction and inflammatory disease. ..
  85. Backlund L, Lavebratt C, Frisén L, Nikamo P, Hukic Sudic D, Traskman Bendz L, et al. P2RX7: expression responds to sleep deprivation and associates with rapid cycling in bipolar disorder type 1. PLoS ONE. 2012;7:e43057 pubmed publisher
    ..This supports earlier findings of P2RX7 associations to affective disorder and is in agreement with that particularly rapid cycling patients have a more vulnerable diurnal system. ..
  86. Rassendren F, Buell G, Virginio C, Collo G, North R, Surprenant A. The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA. J Biol Chem. 1997;272:5482-6 pubmed
    A cDNA was isolated from a human monocyte library that encodes the P2X7 receptor; the predicted protein is 80% identical to the rat receptor...
  87. Narcisse L, Scemes E, Zhao Y, Lee S, Brosnan C. The cytokine IL-1beta transiently enhances P2X7 receptor expression and function in human astrocytes. Glia. 2005;49:245-58 pubmed
    ..These studies suggest that signaling via the P2X7R may modulate the astrocytic response to inflammation in the human central nervous system. ..
  88. Georgiou J, Skarratt K, Fuller S, Martin C, Christopherson R, Wiley J, et al. Human epidermal and monocyte-derived langerhans cells express functional P2X receptors. J Invest Dermatol. 2005;125:482-90 pubmed
    ..in Mo-LC obtained from subjects homozygous for the loss-of-function Glu-496 to Ala polymorphism in the P2X7 receptor. These results demonstrate that human LC express functional P2X7 receptors, and suggest a role for this ..
  89. Guo C, Masin M, Qureshi O, Murrell Lagnado R. Evidence for functional P2X4/P2X7 heteromeric receptors. Mol Pharmacol. 2007;72:1447-56 pubmed
    ..Coexpression of a dominant-negative P2X4 mutant (C353W) with P2X7, inhibited P2X7 receptor mediated currents by greater than 2-fold, whereas a nonfunctional but non-dominant-negative mutant (S341W) did ..
  90. Becker D, Woltersdorf R, Boldt W, Schmitz S, Braam U, Schmalzing G, et al. The P2X7 carboxyl tail is a regulatory module of P2X7 receptor channel activity. J Biol Chem. 2008;283:25725-34 pubmed publisher
    ..Together, these results identify the tail extension as a regulatory gating module, potentially making P2X(7) channel gating sensitive to intracellular regulation. ..
  91. Buell G, Talabot F, Gos A, Lorenz J, Lai E, Morris M, et al. Gene structure and chromosomal localization of the human P2X7 receptor. Receptors Channels. 1998;5:347-54 pubmed
    The genomic organization for the human P2X7 receptor gene was determined to comprise 13 exons...
  92. Gu B, Wiley J. Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor. Blood. 2006;107:4946-53 pubmed
    ..These observations suggest a novel role for P2X(7) as a pro-inflammatory receptor involved in rapid MMP-9 release and leukocyte recruitment. ..