P2X1

Summary

Gene Symbol: P2X1
Description: purinergic receptor P2X, ligand-gated ion channel, 1
Alias: P2X1, ATP receptor, P2X purinoceptor 1, P2X receptor, subunit 1, P2X1 receptor, purinergic receptor P2X1
Species: human

Top Publications

  1. ncbi Potentiation of platelet activation through the stimulation of P2X1 receptors
    J A Erhardt
    GlaxoSmithKline, Department of Vascular Biology, UW2510, 709 Swedeland Road, King of Prussia, PA 19406, USA
    J Thromb Haemost 1:2626-35. 2003
  2. ncbi Cysteinyl-leukotrienes are released from astrocytes and increase astrocyte proliferation and glial fibrillary acidic protein via cys-LT1 receptors and mitogen-activated protein kinase pathway
    Renata Ciccarelli
    Department of Biomedical Sciences, Section of Pharmacology, Medical School, G D Annunzio University of Chieti, Chieti, Italy
    Eur J Neurosci 20:1514-24. 2004
  3. ncbi Molecular physiology of P2X receptors
    R Alan North
    Institute of Molecular Physiology, University of Sheffield, Western Bank, Sheffield, United Kingdom
    Physiol Rev 82:1013-67. 2002
  4. pmc Identification of human P2X1 receptor-interacting proteins reveals a role of the cytoskeleton in receptor regulation
    Ulyana Lalo
    Department of Cell Physiology and Pharmacology, Henry Wellcome Building, University of Leicester, Leicester LE1 9HN, United Kingdom
    J Biol Chem 286:30591-9. 2011
  5. pmc Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel
    Jonathan A Roberts
    Department of Cell Physiology and Pharmacology, University of Leicester, Leicester LE1 9HN, United Kingdom
    Proc Natl Acad Sci U S A 109:4663-7. 2012
  6. pmc Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells
    K Wareham
    Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield, UK
    Br J Pharmacol 157:1215-24. 2009
  7. ncbi The ATP-gated P2X1 ion channel acts as a positive regulator of platelet responses to collagen
    C Oury
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Thromb Haemost 86:1264-71. 2001
  8. pmc Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse
    Tobias Woehrle
    Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Blood 116:3475-84. 2010
  9. doi P2X(1) and P2X(3) purinergic receptors differentially modulate the inflammatory response in human osteoarthritic synovial fibroblasts
    Katia Varani
    Department of Clinical and Experimental Medicine, University of Ferrara, 44100 Ferrara, Italy
    Cell Physiol Biochem 25:325-36. 2010
  10. ncbi The intracellular tyrosine residues of the ATP-gated P2X(1) ion channel are essential for its function
    Emese Toth-Zsamboki
    Center for Molecular and Vascular Biology, University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    FEBS Lett 524:15-9. 2002

Research Grants

Detail Information

Publications159 found, 100 shown here

  1. ncbi Potentiation of platelet activation through the stimulation of P2X1 receptors
    J A Erhardt
    GlaxoSmithKline, Department of Vascular Biology, UW2510, 709 Swedeland Road, King of Prussia, PA 19406, USA
    J Thromb Haemost 1:2626-35. 2003
    The platelet P2X1 purinergic receptor is a ligand-gated ion channel that responds to ATP...
  2. ncbi Cysteinyl-leukotrienes are released from astrocytes and increase astrocyte proliferation and glial fibrillary acidic protein via cys-LT1 receptors and mitogen-activated protein kinase pathway
    Renata Ciccarelli
    Department of Biomedical Sciences, Section of Pharmacology, Medical School, G D Annunzio University of Chieti, Chieti, Italy
    Eur J Neurosci 20:1514-24. 2004
    ..to calcium ionophore A23187, 1 h combined oxygen-glucose deprivation or 2-methyl-thioATP, a selective P2Y(1)/ATP receptor agonist. MK-886, a LT synthesis inhibitor, prevented basal and evoked cys-LT release...
  3. ncbi Molecular physiology of P2X receptors
    R Alan North
    Institute of Molecular Physiology, University of Sheffield, Western Bank, Sheffield, United Kingdom
    Physiol Rev 82:1013-67. 2002
    ..Channels form as multimers of several subunits. Homomeric P2X1, P2X2, P2X3, P2X4, P2X5, and P2X7 channels and heteromeric P2X2/3 and P2X1/5 channels have been most fully ..
  4. pmc Identification of human P2X1 receptor-interacting proteins reveals a role of the cytoskeleton in receptor regulation
    Ulyana Lalo
    Department of Cell Physiology and Pharmacology, Henry Wellcome Building, University of Leicester, Leicester LE1 9HN, United Kingdom
    J Biol Chem 286:30591-9. 2011
    ..Disruption of the actin cytoskeleton with cytochalasin D inhibited P2X1 receptor currents with no effect on the time course of the response or surface expression of the receptor...
  5. pmc Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel
    Jonathan A Roberts
    Department of Cell Physiology and Pharmacology, University of Leicester, Leicester LE1 9HN, United Kingdom
    Proc Natl Acad Sci U S A 109:4663-7. 2012
    ..methanethiosulfonate) to show ATP-sensitive accessibility of cysteine mutants at the human P2X1 receptor. Mapping these data to a P2X1 receptor homology model identifies significant conformational rearrangement...
  6. pmc Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells
    K Wareham
    Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield, UK
    Br J Pharmacol 157:1215-24. 2009
    ..P2X receptors are widely expressed in cells of the immune system with varying functions. This study sought to characterize P2X receptor expression in the LAD2 human mast cell line and human lung mast cells (HLMCs)...
  7. ncbi The ATP-gated P2X1 ion channel acts as a positive regulator of platelet responses to collagen
    C Oury
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Thromb Haemost 86:1264-71. 2001
    ATP is a potent agonist of the P2X1 ion channel, mediating a rapid, quickly desensitized influx of Ca2+...
  8. pmc Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse
    Tobias Woehrle
    Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Blood 116:3475-84. 2010
    ..TCR stimulation results in the translocation of P2X1 and P2X4 receptors and pannexin-1 hemichannels to the immune synapse, while P2X7 receptors remain uniformly ..
  9. doi P2X(1) and P2X(3) purinergic receptors differentially modulate the inflammatory response in human osteoarthritic synovial fibroblasts
    Katia Varani
    Department of Clinical and Experimental Medicine, University of Ferrara, 44100 Ferrara, Italy
    Cell Physiol Biochem 25:325-36. 2010
    ....
  10. ncbi The intracellular tyrosine residues of the ATP-gated P2X(1) ion channel are essential for its function
    Emese Toth-Zsamboki
    Center for Molecular and Vascular Biology, University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    FEBS Lett 524:15-9. 2002
    ..Thus, Y16, Y362, Y363 and Y370 are required for the appropriate three-dimensional structure and function of the intracellular P2X(1) domains...
  11. doi ATP-gated P2X1 ion channels protect against endotoxemia by dampening neutrophil activation
    C Lecut
    GIGA Research, Human Genetics Unit, Laboratory of Cardiovascular Research, University of Liege, Liege, Belgium, France
    J Thromb Haemost 10:453-65. 2012
    ..Previously, we showed that, in addition to their role in platelet activation, ATP-gated P2X(1) ion channels are involved in promoting neutrophil chemotaxis...
  12. doi ATP-induced vasodilation and purinergic receptors in the human leg: roles of nitric oxide, prostaglandins, and adenosine
    Stefan P Mortensen
    The Copenhagen Muscle Research Centre, Rigshospitalet, Section 7652, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Am J Physiol Regul Integr Comp Physiol 296:R1140-8. 2009
    ..The expression and localization of the nucleotide selective P(2Y2) and P(2X1) receptors suggest that these receptors may mediate ATP-induced vasodilation in skeletal muscle...
  13. ncbi Overexpression of the platelet P2X1 ion channel in transgenic mice generates a novel prothrombotic phenotype
    Cecile Oury
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Blood 101:3969-76. 2003
    ..Activation of the ERK2 pathway is instrumental in these processes...
  14. doi P2X1 ion channels promote neutrophil chemotaxis through Rho kinase activation
    Christelle Lecut
    GIGA Research Human Genetics Unit, University of Liege, Liege, Belgium
    J Immunol 183:2801-9. 2009
    ..These ion channels may therefore play a significant role in host defense and inflammation...
  15. pmc Disruption of lipid rafts inhibits P2X1 receptor-mediated currents and arterial vasoconstriction
    Catherine Vial
    Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, LE1 9HN United Kingdom
    J Biol Chem 280:30705-11. 2005
    ..To determine whether lipid raft association was essential for P2X1 receptor channel function we used the cholesterol-depleting agent methyl-beta-cyclodextrin (10 mm for 1 h)...
  16. ncbi A major role for P2X1 receptors in the early collagen-evoked intracellular Ca2+ responses of human platelets
    C Y Eleanor Fung
    Department of Physiology, University of Cambridge, Cambridge, CB2 3EG, UK
    Thromb Haemost 94:37-40. 2005
    ..We now report that selective desensitisation of P2X1 receptor activity leads to a major reduction in the initial intracellular Ca2+ responses to a wide range of collagen ..
  17. ncbi Contribution of conserved glycine residues to ATP action at human P2X1 receptors: mutagenesis indicates that the glycine at position 250 is important for channel function
    Helen R Digby
    Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, UK
    J Neurochem 95:1746-54. 2005
    ..mutated individual conserved glycine residues and determined their effect on the ATP sensitivity and time-course of P2X1 receptors expressed in Xenopus oocytes...
  18. ncbi Reduced vas deferens contraction and male infertility in mice lacking P2X1 receptors
    K Mulryan
    Department of Cell Physiology and Pharmacology, University of Leicester, UK
    Nature 403:86-9. 2000
    ..Here we show that male fertility is reduced by approximately 90% in mice with a targeted deletion of the P2X1 receptor gene...
  19. pmc Cysteine scanning mutagenesis (residues Glu52-Gly96) of the human P2X1 receptor for ATP: mapping agonist binding and channel gating
    Rebecca C Allsopp
    Department of Cell Physiology and Pharmacology, University of Leicester, Leicester LE1 9HN, United Kingdom
    J Biol Chem 286:29207-17. 2011
    ..We have used cysteine-scanning mutagenesis to determine the contribution of residues Glu(52)-Gly(96) to human P2X1 receptor properties. ATP potency was reduced for the mutants K68C, K70C, and F92C...
  20. pmc P2X1 receptor mobility and trafficking; regulation by receptor insertion and activation
    Ulyana Lalo
    Department of Cell Physiology and Pharmacology, Henry Wellcome Building, University of Leicester, Leicester, UK
    J Neurochem 113:1177-87. 2010
    ..Following activation of the P2X1 receptor with alpha,beta-methylene ATP the associated calcium influx doubled the FRAP recovery rate...
  21. pmc Lipid raft association and cholesterol sensitivity of P2X1-4 receptors for ATP: chimeras and point mutants identify intracellular amino-terminal residues involved in lipid regulation of P2X1 receptors
    Rebecca C Allsopp
    Department of Cell Physiology and Pharmacology, University of Leicester, Leicester LE1 9HN, United Kingdom
    J Biol Chem 285:32770-7. 2010
    ..The cholesterol-depleting agents methyl-β-cyclodextrin or filipin disrupt lipid rafts and reduced P2X1 receptor currents by >90%. In contrast, ATP-evoked P2X2-4 receptor currents were unaffected by lipid raft disruption...
  22. ncbi Differential sensitivity of human platelet P2X1 and P2Y1 receptors to disruption of lipid rafts
    Catherine Vial
    Department of Cell Physiology and Pharmacology, University of Leicester, Leicester LE1 9HN, UK
    Biochem Biophys Res Commun 343:415-9. 2006
    ..We show that disruption of cholesterol-rich membrane lipid rafts reduces P2X1 receptor-mediated calcium increases by approximately 80%, while P2Y1 receptor-dependent Ca2+ release is unaffected...
  23. ncbi ATP binding at human P2X1 receptors. Contribution of aromatic and basic amino acids revealed using mutagenesis and partial agonists
    Jonathan A Roberts
    Department of Cell Physiology and Pharmacology, University of Leicester, University Road, Leicester LE1 9HN, United Kingdom
    J Biol Chem 279:9043-55. 2004
    ..These results suggest that residues Lys-68, Phe-185, Phe-291, Arg-292, and Lys-309 contribute to ligand binding at P2X(1) receptors, with Phe-185 and Phe-291 coordinating the binding of the adenine ring of ATP...
  24. ncbi Regulation of human P2X1 promoter activity by beta helix-loop-helix factors in smooth muscle cells
    P D Dhulipala
    Department of Medicine, Division of Nephrology, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Gene 269:167-75. 2001
    We isolated and characterized genomic clones of the human P2X1 receptor (hP2X1) gene in an effort to understand its tissue specific expression. The hP2X1 gene contains 12 exons spanning 20 kb, with exon sizes ranging from 59 to 143 bp...
  25. ncbi The P2X1 receptor, an adenosine triphosphate-gated cation channel, is expressed in human platelets but not in human blood leukocytes
    E E Clifford
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Blood 91:3172-81. 1998
    ..Electrophysiological and biochemical studies have indicated expression of the P2X1 receptor, an ATP-gated cation channel, in human and rat platelets, rat basophilic leukemia (RBL) cells, and phorbol ..
  26. ncbi ATP-gamma-S shifts the operating point of outer hair cell transduction towards scala tympani
    Richard P Bobbin
    Kresge Hearing Research Laboratory, Department of Otolaryngology, Louisiana State University School of Medicine, New Orleans, LA 70112 2234, USA
    Hear Res 205:35-43. 2005
    b>ATP receptor agonists and antagonists alter cochlear mechanics as measured by changes in distortion product otoacoustic emissions (DPOAE)...
  27. pmc P2X antagonists inhibit styryl dye entry into hair cells
    M A Crumling
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan Medical School, 4605 MS II, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5616, USA
    Neuroscience 161:1144-53. 2009
    ..However, such dyes can also permeate the ATP receptor, P2X(2). Therefore, we explored the contribution of P2X receptors to the loading of hair cells with AM1-43...
  28. ncbi P2Y2 receptor up-regulation induced by guanosine or UTP in rat brain cultured astrocytes
    P Ballerini
    Dept of Biomedical Sciences, Section of Pharmacology and Toxicology, Medical School, University G d Annunzio of Chieti Pescara, Via dei Vestini 29, 66013 Chieti, Italy
    Int J Immunopathol Pharmacol 19:293-308. 2006
    ..yet been studied and little is known about the mechanisms underlying the regulation of the expression of this ATP receptor. We showed that not only UTP and ATP are the most potent and naturally occurring agonist for P2Y2 sites, but ..
  29. ncbi Recombinant P2Y receptors: the UCL experience
    B F King
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, Hampstead, NW3 2PF, London, UK
    J Auton Nerv Syst 81:164-70. 2000
    ..A., Gibb, A.J., Colquhoun, D., 1992. ATP receptor-mediated synaptic currents in the central nervous system. Nature 359, 144-147; Evans, R.J., Derkach, V...
  30. pmc Membrane-delimited coupling between sigma receptors and K+ channels in rat neurohypophysial terminals requires neither G-protein nor ATP
    P J Lupardus
    Departments of Physiology, Medicine, Molecular Biology and Pharmacology, University of Wisconsin School of Medicine, 1300 University Avenue, Madison, WI 53706, USA
    J Physiol 526:527-39. 2000
    ..This would allow for more rapid signal transduction than other ion channel modulation mechanisms, which in the present case of neurohypophysial nerve terminals would lead to the enhancement of neuropeptide release...
  31. ncbi Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems
    S A Deuchars
    School of Biomedical Sciences, University of Leeds, LS2 9NQ, Leeds, United Kingdom
    J Neurosci 21:7143-52. 2001
    The ionotropic ATP receptor subunits P2X(1-6) receptors play important roles in synaptic transmission, yet the P2X(7) receptor has been reported as absent from neurons in the normal adult brain...
  32. ncbi NAD+ released during inflammation participates in T cell homeostasis by inducing ART2-mediated death of naive T cells in vivo
    Sahil Adriouch
    University Denis Diderot Paris 7, EA 1556 Paris, France
    J Immunol 179:186-94. 2007
    ..In vitro, ADP-ribosylation by ART2 activates the P2X7 ATP receptor and is responsible for NAD(+)-induced T cell death (NICD)...
  33. ncbi Neurochemical characterisation of sensory receptors in airway smooth muscle: comparison with pulmonary neuroepithelial bodies
    Inge Brouns
    Laboratory of Cell Biology and Histology, Department of Biomedical Sciences, University of Antwerp, Groenenborgerlaan 171, 2020, Antwerp, Belgium
    Histochem Cell Biol 125:351-67. 2006
    ..alpha3, vesicular glutamate transporter 1 (VGLUT1) and VGLUT2-immunoreactivity, expression of the ATP receptor P2X(3), and the presence of calcium-binding proteins...
  34. ncbi Interaction between purinoceptor subtypes on hippocampal serotonergic transmission using in vivo microdialysis
    M Okada
    Department of Neuropsychiatry, Hirosaki University, Japan
    Neuropharmacology 38:707-15. 1999
    ..The P2X1-7 active P2 purinoceptor agonist, 2-methylthioATP (2-MeSATP: 100 microM) increased the extracellular serotonin ..
  35. ncbi Modulation of the effects of extracellular ATP on [Ca2+]i in rat brain microvacular endothelial cells
    M Nobles
    King s College London, Biomedical Sciences Division, Physiology Group, Strand, UK
    Eur J Pharmacol 361:119-27. 1998
    ..The modulation of the Ca2+ signal downstream to the activation of the ATP receptor was investigated, using agents selected for their ability to interfere with the intracellular pathways ..
  36. ncbi Platelet P2 receptors: old and new targets for antithrombotic drugs
    Marco Cattaneo
    Universita degli Studi di Milano, Unità di Ematologia e Trombosi Ospedale San Paolo, Via di Rudinì 820142 Milano, Italy
    Expert Rev Cardiovasc Ther 5:45-55. 2007
    Platelets possess three P2 receptors for adenine nucleotides: P2Y1 and P2Y12, which interact with ADP, and P2X1, which interacts with ATP...
  37. ncbi Novel variant of the P2X2 ATP receptor from the guinea pig organ of Corti
    M S Parker
    Department Otorhinolaryngology and Biocommunication, Louisiana State University Medical Center, New Orleans 70112 2234, USA
    Hear Res 121:62-70. 1998
    ..The multiple transcripts arise from alternative intron and exon splicing events. In situ hybridization with a probe common to the three variants localized P2X2 to many of the cells of the organ of Corti...
  38. ncbi Purinergic (P2) receptor control of lower genitourinary tract function and new avenues for drug action: an overview
    Serap Gur
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Curr Pharm Des 13:3236-44. 2007
    ..In the prostate, P2X1-receptors, which mediate contraction, are present in the fibromuscular stroma while G protein-coupled P2Y ..
  39. ncbi Lysophosphatidylcholine stimulates IL-1beta release from microglia via a P2X7 receptor-independent mechanism
    Christian Stock
    Institute of Physiology II, University of Muenster, Muenster, Germany
    J Immunol 177:8560-8. 2006
    ..of IL-1beta release from activated microglia (brain macrophages) that occurred independently of P2X(7) ATP receptor activation...
  40. ncbi P2X receptors in the rat uterine cervix, lumbosacral dorsal root ganglia, and spinal cord during pregnancy
    Raymond E Papka
    Department of Neurobiology, Northeastern Ohio Universities College of Medicine, P O Box 95, 4209 State RT 44, Rootstown, OH 44272, USA
    Cell Tissue Res 321:35-44. 2005
    ..The P2X subtype of the ATP receptor is expressed in rat dorsal root ganglion (DRG) cells, spinal cord dorsal horn, and axons in peripheral tissues...
  41. doi P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain
    Kimiko Kobayashi
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    J Neurosci 28:2892-902. 2008
    ..A metabotropic ATP receptor, P2Y(12), has been shown to be expressed in spinal microglia constitutively and be involved in chemotaxis...
  42. ncbi ATP modulates the release of noradrenaline through two different prejunctional receptors on the adrenergic nerves of rat prostate
    Tsugumi Morikawa
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Clin Exp Pharmacol Physiol 34:601-5. 2007
    1. The effects of adenosine and ATP receptor agonists on the release of endogenous noradrenaline from electrically stimulated (2 Hz, 0...
  43. ncbi Activation of P2X(7) receptors stimulates the expression of P2Y(2) receptor mRNA in astrocytes cultured from rat brain
    I D'Alimonte
    Department of Biomedical Sciences, University of Chieti Pescara, Chieti, Italy
    Int J Immunopathol Pharmacol 20:301-16. 2007
    ..we report that the most potent P2X(7) receptor agonist BzATP stimulates the expression of the metabotropic ATP receptor P2Y(2) in cultured rat brain astrocytes...
  44. ncbi Molecular cloning and functional characterization of a rat pituitary G protein-coupled adenosine triphosphate (ATP) receptor
    Z P Chen
    Department of Medicine, University of Bristol, Bristol Royal Infirmary, England
    Endocrinology 137:1833-40. 1996
    ..This work reports the isolation and expression of a pituitary ATP receptor gene clone from a rat pituitary complementary DNA library...
  45. ncbi Properties of ATP receptor-mediated synaptic transmission in the rat medial habenula
    F A Edwards
    Department of Physiology, University College London, U K
    Neuropharmacology 36:1253-68. 1997
    ....
  46. pmc Emerging peripheral receptor targets for deep-tissue craniofacial pain therapies
    R Ambalavanar
    Department of Neural and Pain Sciences and Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
    J Dent Res 88:201-11. 2009
    ..For example, expression of the ATP receptor P2X(3) is strongly implicated in nociception and is more abundant on trigeminal primary afferent neurons than ..
  47. doi Management of erectile function by penile purinergic p2 receptors in the diabetic rat
    Serap Gur
    Department of Urology and Pharmacology, Tulane Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Urol 181:2375-82. 2009
    ..We determined the role of purine and pyrimidine nucleotides in erectile function in diabetic rats...
  48. ncbi The P2X7 ATP receptor modulates renal cyst development in vitro
    Kate A Hillman
    Nephrology and Physiology, Royal Free Campus, Institute of Child Health, University College London, London, UK
    Biochem Biophys Res Commun 322:434-9. 2004
    ..Thus, ATP may inhibit pathological renal cyst growth through P2X(7) signaling...
  49. ncbi The P2X7 ATP receptor in the kidney: a matter of life or death?
    K A Hillman
    Centre for Nephrology, Department of Physiology, Royal Free and University College Medical School, UCL, London, UK
    Nephron Exp Nephrol 101:e24-30. 2005
    ..Further investigation of the function of the P2X7 receptor in normal and abnormal kidneys might lead to novel therapeutic targets in a wide range of renal diseases...
  50. ncbi Modulation of gene expression by moxonidine in rats with chronic renal failure
    Oliver Vonend
    Marienhospital Herne, Ruhr Universitat Bochum, Hölkeskampring 40, D 44625 Herne, Germany
    Nephrol Dial Transplant 19:2217-22. 2004
    ..The present study investigates whether moxonidine influences the expression of genes associated with adaptive changes in kidneys of subtotally nephrectomized rats...
  51. pmc Functional evidence that ATP or a related purine is an inhibitory NANC neurotransmitter in the mouse jejunum: study on the identity of P2X and P2Y purinoceptors involved
    Joris G De Man
    Division of Gastroenterology, Faculty of Medicine, University of Antwerp, Universiteitsplein 1, Wilrijk B 2610, Belgium
    Br J Pharmacol 140:1108-16. 2003
    ..5. Desensitisation of alphabetaMeATP-sensitive P2X receptors, the P2X receptor blocker Evans blue and the P2X1,2,3 receptor blocker NF 279 inhibited the l-NOARG-resistant NANC relaxations to EFS and that to alphabetaMeATP ..
  52. ncbi ATP receptor-mediated synaptic currents in the central nervous system
    F A Edwards
    Department of Pharmacology, University College London, UK
    Nature 359:144-7. 1992
    ..unaffected by blockers of glutamate, gamma-aminobutyric acid or acetylcholine receptors but were blocked by the ATP receptor-blocker, suramin and the desensitizing ATP receptor-agonist alpha,beta-methylene-ATP...
  53. pmc Stimulation of rat erythrocyte P2X7 receptor induces the release of epoxyeicosatrienoic acids
    H Jiang
    Department of Pharmacology, New York Medical College, Valhalla, NY, USA
    Br J Pharmacol 151:1033-40. 2007
    ..This study addresses the formation and release of erythrocyte-derived EETs in response to ATP receptor stimulation that may represent an important mechanism regarding circulatory regulation.
  54. ncbi P2X purinergic receptor antagonist accelerates skin barrier repair and prevents epidermal hyperplasia induced by skin barrier disruption
    Mitsuhiro Denda
    Shiseido Research Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama, Japan
    J Invest Dermatol 119:1034-40. 2002
    The effects of ATP receptor agonists/antagonists on skin barrier recovery rate were evaluated in hairless mice. Topical application of ATP and alpha,beta-methylene ATP (agonist of P2X receptor) delayed barrier recovery...
  55. ncbi Cloning and functional expression of a brain G-protein-coupled ATP receptor
    T E Webb
    Molecular Neurobiology Unit, Royal Free Hospital School of Medicine, London, UK
    FEBS Lett 324:219-25. 1993
    A cDNA encoding a novel member of the G-protein-coupled receptor (GCR) superfamily, an ATP receptor, has been isolated from an embryonic chick whole brain cDNA library by hybridization screening...
  56. ncbi Cloning and expression of a P2y purinoceptor from the adult bovine corpus callosum
    G Deng
    Department of Psychobiology, University of California at Irvine 92697, USA
    Neurobiol Dis 5:259-70. 1998
    We have isolated an ATP receptor clone by screening a bovine corpus callosum cDNA library...
  57. ncbi A primitive ATP receptor from the little skate Raja erinacea
    J A Dranoff
    Department of Medicine and Liver Study Unit, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 275:30701-6. 2000
    ..Functional evidence suggests that hepatocytes from the little skate Raja erinacea express a primitive P2Y ATP receptor lacking pharmacologic selectivity, so we cloned and characterized this receptor...
  58. ncbi Quantification of ADP and ATP receptor expression in human platelets
    L Wang
    Department of Cardiology, Lund University Hospital, Lund, Sweden
    J Thromb Haemost 1:330-6. 2003
    ..Incubation in vitro revealed a more rapid degradation rate for P2X1 receptor mRNA than for P2Y1 and P2Y12, indicating that the level of P2X1 may be relatively higher in newly released ..
  59. ncbi Mechanism of interferon action. X--Antagonistic effect of ATP on pppA2'p5'A2'p5'A receptor
    S W Li
    Shanghai Institute of Biochemistry, Academia Sinica
    Sci Sin B 31:304-12. 1988
    ..But ATP can compete with 2'-5'P3A3 for the receptor. This raises a question whether this is an ATP receptor. If not, what is the role of ATP for this receptor? Data available in this article show that ATP can bind to ..
  60. pmc Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth
    Elena Adinolfi
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, and Interdisciplinary Center for the Study of Inflammation, University of Ferrara, 44100 Ferrara, Italy
    Mol Biol Cell 16:3260-72. 2005
    ..These findings reveal a hitherto undescribed mechanism for growth stimulation by a plasma membrane pore...
  61. ncbi New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
    A J Brake
    Department of Pharmacology, University of California, San Francisco 94143 0450
    Nature 371:519-23. 1994
    ..There is sequence similarity between the ATP receptor and RP-2, a gene activated in thymocytes undergoing programmed cell death...
  62. pmc Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells
    Shunichi Shimizu
    Department of Pathophysiology, School of Pharmaceutical Sciences, Showa University, Shinagawa ku, Tokyo, Japan
    J Physiol 570:219-35. 2006
    ..Ca(2+) entry through TRPC5 channels, induced upon stimulation of the G-protein-coupled ATP receptor, was abolished by treatment with W-13, an inhibitor of calmodulin...
  63. pmc Expression cloning of an ATP receptor from mouse neuroblastoma cells
    K D Lustig
    Department of Pharmacology, University of California, San Francisco 94143
    Proc Natl Acad Sci U S A 90:5113-7. 1993
    ..mRNA encoding the P2U purinergic receptor is found in neural and nonneural tissues...
  64. ncbi Identification of negative residues in the P2X3 ATP receptor ectodomain as structural determinants for desensitization and the Ca2+-sensing modulatory sites
    Elsa Fabbretti
    Neurobiology Sector, International School for Advanced Studies SISSA, Via Beirut 4, 34014 Trieste, Italy
    J Biol Chem 279:53109-15. 2004
    ..Thus, these findings outline diverse potential molecular targets to modulate P2X(3) receptor function in relation to its functional state...
  65. ncbi Cloning and pharmacological characterization of a fourth P2X receptor subtype widely expressed in brain and peripheral tissues including various endocrine tissues
    C Z Wang
    Center for Biomedical Science, Chiba University School of Medicine, Inohana, Chuo Ku, Japan
    Biochem Biophys Res Commun 220:196-202. 1996
    We have isolated cDNA encoding a fourth member (P2X-4) of the ATP receptor P2X receptor family from a rat pancreatic islet cDNA library...
  66. pmc Dynamic aspects of functional regulation of the ATP receptor channel P2X2
    Yoshihiro Kubo
    Division of Biophysics and Neurobiology, Department of Molecular Physiology, National Institute for Physiological Sciences, Okazaki, Aichi, Japan
    J Physiol 587:5317-24. 2009
    ..Complete elucidation of these regulatory mechanisms awaits dynamic imaging of functioning P2X(2) channels...
  67. ncbi Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor
    T Okada
    Laboratory of Humoral Information, Department of Information Physiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    J Biol Chem 274:27359-70. 1999
    ..TRP7 induced Ca(2+) influx in response to ATP receptor stimulation at ATP concentrations lower than those necessary for activation of TRP3 and for Ca(2+) release from ..
  68. ncbi P2X receptors-mediated cytosolic phospholipase A2 activation in primary afferent sensory neurons contributes to neuropathic pain
    Makoto Tsuda
    Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi, Fukuoka, Japan
    J Neurochem 103:1408-16. 2007
    Activation of P2X(3) and P2X(2/3) receptors (P2X(3)R/P2X(2/3)R), ionotropic ATP receptor subtypes, in primary sensory neurons is involved in neuropathic pain, a debilitating chronic pain that occurs after peripheral nerve injury...
  69. doi Neurotoxic species of misfolded SOD1G93A recognized by antibodies against the P2X4 subunit of the ATP receptor accumulate in damaged neurons of transgenic animal models of amyotrophic lateral sclerosis
    Sara Hernandez
    From the Universitat de Lleida, Facultat de Medicina, Departament de Medicina Experimental, Unitat de Neurobiologia Cel lular, and IRBLLEIDA, Lleida, Catalonia, Spain
    J Neuropathol Exp Neurol 69:176-87. 2010
    ..We conclude that neuronal SOD1 conformers with P2X(4)-LIR may have pathogenetic relevance in the promotion of neuroinflammation...
  70. doi P2Y12 receptor-mediated integrin-beta1 activation regulates microglial process extension induced by ATP
    Keiko Ohsawa
    Department of Neurochemistry, National Institute of Neuroscience, Kodaira, Tokyo 187 8502, Japan
    Glia 58:790-801. 2010
    ..rapidly extend their processes toward the damaged areas in response to stimulation of the metabotropic ATP receptor P2Y(12) by ATP released from damaged tissue...
  71. ncbi P2X7-related modulation of pathological nociception in rats
    S McGaraughty
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R4PM, AP9 1, 100 Abbott Park Road, Abbott Park, IL 60064 6118, USA
    Neuroscience 146:1817-28. 2007
    ..ATP is a key neurotransmitter in this process. Recent studies demonstrate that the glial ATP receptor, P2X7, contributes to the modulation of pathological pain...
  72. doi Large-conductance channel formation mediated by P2X7 receptor activation is regulated through distinct intracellular signaling pathways in peritoneal macrophages and 2BH4 cells
    R X Faria
    Laboratory of Cellular Communication, Department of Immunology, Oswaldo Cruz Institute, FIOCRUZ Oswaldo Cruz Foundation, Av Brazil, 4365, Manguinhos, Rio de Janeiro 21045 900, Brazil
    Naunyn Schmiedebergs Arch Pharmacol 382:73-87. 2010
    The P2X(7) receptor (P2X7R) is a ligand-gated ATP receptor that acts as a low- and large-conductance channel (pore) and is known to be coupled to several downstream effectors...
  73. ncbi Characterisation of subtypes of the P2X and P2Y families of ATP receptors in the foetal human heart
    Y Bogdanov
    Department of Anatomy and Developmental Biology, University College London, UK
    Life Sci 62:697-703. 1998
    ..In order to characterise the ATP receptor subtypes involved in these effects, degenerate oligonucleotides were used to clone receptors of both P2X and ..
  74. ncbi Enhanced thermal avoidance in mice lacking the ATP receptor P2X3
    Isao Shimizu
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 408 Biophysics Building, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Pain 116:96-108. 2005
    ..in wild-type mice injected subcutaneously with the P2X3 antagonist, A317491 or intrathecally with the P2X3 and P2X1 antagonist TNP-ATP...
  75. ncbi The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA
    F Rassendren
    Geneva Biomedical Research Institute, GlaxoWellcome Research and Development, Plan les Ouates, 1228 Geneva, Switzerland
    J Biol Chem 272:5482-6. 1997
    ..Expression of chimeric molecules indicated that some of the differences between the rat and human receptor could be reversed by exchanging the intracellular C-terminal domain of the proteins...
  76. ncbi Increased platelet purinergic sensitivity in peripheral arterial disease--a pilot study
    Oscar O Braun
    Department of Cardiology, Lund University Hospital, Lund, Sweden
    Platelets 16:261-7. 2005
    ..Platelets express three different purinergic receptors: P2Y1, P2Y12 and P2X1. We assessed the hypothesis that the hyperaggregability associated with PAD is partly due to an increased P2 ..
  77. ncbi P2X1 receptor currents after disruption of the PKC site and its surroundings by dominant negative mutations in HEK293 cells
    Guo Jun Liu
    The Neurobiology Laboratory, Department of Physiology and Institute for Biomedical Research, University of Sydney, New South Wales 2006, Australia
    Auton Neurosci 108:12-6. 2003
    It has been suggested that phosphorylation at the T18P19R20 PKC sites of the P2X1 receptor regulates its functions...
  78. ncbi Impaired Ca2+ signaling attenuates P2X receptor-mediated vasoconstriction of afferent arterioles in angiotensin II hypertension
    Xueying Zhao
    Vascular Biology Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912 3000, USA
    Hypertension 46:562-8. 2005
    ..These results indicate that the impaired autoregulatory response observed in Ang II-dependent hypertension can be attributed to impairment of P2X1 receptor-mediated signal transduction.
  79. ncbi ATP-stimulated ANP release through P1 receptor subtype
    Chunhua Cao
    Department of Physiology, Medical School, Institute for Medical Sciences, Chonbuk National University, 2 20 Keum Am Dong San, JeonJu 561 180, Korea
    Regul Pept 127:37-43. 2005
    ..also caused an increase in ANP release with similarity to ATP, but alpha,beta-methylene ATP (alpha,beta-MeATP, P2X1 receptor agonist) and 2-methylthioADP (2-MesADP, P2Y1 receptor agonist) did not...
  80. doi P2X1 receptor-mediated inhibition of the proliferation of human coronary smooth muscle cells involving the transcription factor NR4A1
    Annette Viktoria Hinze
    Federal Institute for Drugs and Medical Devices, Kurt Georg Kiesinger Allee 3, 53175, Bonn, Germany
    Purinergic Signal 9:677-86. 2013
    ..3 and 0.08 μM, respectively. The effects were abolished or markedly attenuated by the P2X1 receptor antagonist NF449 (carbonylbis-imino-benzene-triylbis-(carbonylimino)tetrakis-benzene-1,3-disulfonic acid; 100 ..
  81. pmc Voltage- and [ATP]-dependent gating of the P2X(2) ATP receptor channel
    Yuichiro Fujiwara
    Division of Biophysics and Neurobiology, Department of Molecular Physiology, National Institute for Physiological Sciences, Aichi, Japan
    J Gen Physiol 133:93-109. 2009
    ..We then executed simulation analyses using the calculated rate constants and successfully reproduced the results observed experimentally, voltage-dependent activation that is accelerated by increases in [ATP]...
  82. ncbi Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist
    Jürgen Rettinger
    Department of Molecular Pharmacology, Medical School of the Technical University of Aachen, Wendlingweg 2, D 52074 Aachen, Germany
    Neuropharmacology 48:461-8. 2005
    ..Altogether, these results characterize NF449 as the so far most potent and selective antagonist of receptors incorporating the P2X(1) subunit such as the P2X(1) homomer and the P2X(1 + 5) heteromer...
  83. doi Valproic acid attenuates microgliosis in injured spinal cord and purinergic P2X4 receptor expression in activated microglia
    Wen Hsin Lu
    Department of Life Sciences, National Cheng Kung University, Tainan, Taiwan
    J Neurosci Res 91:694-705. 2013
    ..2013 Wiley Periodicals, Inc...
  84. ncbi Agonists and antagonists acting at P2X receptors: selectivity profiles and functional implications
    G Lambrecht
    Department of Pharmacology, Biocentre Niederursel, University of Frankfurt, Main, Germany
    Naunyn Schmiedebergs Arch Pharmacol 362:340-50. 2000
    ..In the past 7 years, an extended series (P2X1-7) of P2X subunits has been cloned from vertebrate tissues...
  85. pmc Purinergic receptors are required for HIV-1 infection of primary human macrophages
    Joy E Hazleton
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 188:4488-95. 2012
    ..Our data implicate a novel role for a family of host proteins in HIV replication in macrophages and suggest new therapeutic targets to reduce the devastating consequences of HIV infection and AIDS...
  86. ncbi Antagonistic properties of the suramin analogue NF023 at heterologously expressed P2X receptors
    F Soto
    Max Planck Institute for Experimental Medicine, Gottingen, Germany
    Neuropharmacology 38:141-9. 1999
    ..the present study, the effect of NF023 on voltage-clamped Xenopus oocytes heterologously expressing homomultimeric P2X1-P2X4 as well as heteromultimeric P2X2/P2X3 receptors has been characterized...
  87. doi Exhaustive swimming differentially inhibits P2X1 receptor- and α1-adrenoceptor-mediated vasoconstriction in isolated rat arteries
    Lu Li
    Department of Pharmacology, Institute of Chinese Integrative Medicine, Hebei Medical University, Shijiazhuang, China
    Acta Pharmacol Sin 33:221-9. 2012
    To investigate the effects of exhaustive swimming exercise on P2X1 receptor- and α1-adrenoceptor-mediated vasoconstriction of different types of arteries in rats.
  88. pmc Postsynaptic mechanisms of CO(2) responses in parafacial respiratory neurons of newborn rats
    Hiroshi Onimaru
    Department of Physiology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    J Physiol 590:1615-24. 2012
    ..We found that ATP receptor and substance P receptor antagonists do not block membrane potential responses to hypercapnic stimulation (2%→..
  89. pmc Involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor
    Eva Lörinczi
    Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, 37075 Gottingen, Germany
    Proc Natl Acad Sci U S A 109:11396-401. 2012
    ..We also conclude that P2XR activation and desensitization involve movements of the cysteine-rich head domain...
  90. pmc Agonist and antagonist effects of diadenosine tetraphosphate, a platelet dense granule constituent, on platelet P2Y1, P2Y12 and P2X1 receptors
    Hung Chang
    Center for Platelet Function Studies, Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA, USA
    Thromb Res 125:159-65. 2010
    ..Diadenosine 5',5'''-P(1),P(4)- tetraphosphate (Ap(4)A) is stored in platelet dense granules, but its effects on platelet function are not well understood...
  91. doi Pain and purinergic signaling
    Makoto Tsuda
    Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi, Fukuoka 812 8582, Japan
    Brain Res Rev 63:222-32. 2010
    ..P2X receptors (seven types; P2X1-P2X7) contain intrinsic pores that open by binding with ATP, and P2Y receptors (eight types; P2Y1, 2, 4, 6, 11, 12, ..
  92. ncbi Unique functional properties of a sensory neuronal P2X ATP-gated channel from zebrafish
    E Boue-Grabot
    Cell Biology of Excitable Tissue Research Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Neurochem 75:1600-7. 2000
    We report here the structural and functional characterization of an ionotropic P2X ATP receptor from the lower vertebrate zebrafish (Danio rerio)...
  93. ncbi P2X2 receptor expression by interstitial cells of Cajal in vas deferens implicated in semen emission
    L D Burton
    Department of Physiology, Faculty of Medicine and Health Sciences, University of Auckland, New Zealand
    Auton Neurosci 84:147-61. 2000
    ..b>P2X1 receptor immunolabelling was associated with sympathetic innervation of the smooth muscle in the outer longitudinal and ..
  94. ncbi Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes
    D Communi
    Institute of Interdisciplinary Research, School of Medicine, Universite Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium
    J Biol Chem 276:16561-6. 2001
    The P2Y(11) receptor is an ATP receptor positively coupled to the cAMP and phosphoinositide pathways. Ssf1 is a Saccharomyces cerevisiae nuclear protein, which plays an important role in mating...
  95. pmc Rho-kinase inhibition reduces pressure-mediated autoregulatory adjustments in afferent arteriolar diameter
    Edward W Inscho
    Department of Physiology, Medical College of Georgia, 1120 15th St, Augusta, Georgia 30912 3000, USA
    Am J Physiol Renal Physiol 296:F590-7. 2009
    ..afferent arteriolar autoregulatory behavior and vasoconstrictor responses evoked by angiotensin II and P2X1 receptor activation. Rat kidneys were studied in vitro using the blood-perfused juxtamedullary nephron technique...
  96. ncbi Spatial distribution and developmental appearance of postjunctional P2X1 receptors on smooth muscle cells of the mouse vas deferens
    S X Liang
    Department of Physiology F13, University of Sydney, NSW 2006, Australia
    Synapse 42:1-11. 2001
    ..Immunofluorescence staining of the vas deferens with antibodies against P2X1 receptor showed a diffuse, grainy distribution over the entire membrane of each smooth muscle cell...
  97. doi Purinergic receptors and calcium signalling in human pancreatic duct cell lines
    Mette R Hansen
    Department of Biology, August Krogh Building, University of Copenhagen, Denmark
    Cell Physiol Biochem 22:157-68. 2008
    ..and also Capan-1 cells, express RNA transcripts for the following receptors: P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14 and P2X1, P2X2, P2X4, P2X5, P2X6 and P2X7...
  98. ncbi Role of P2X receptors in positive inotropic effect of rat myocardium during ontogeny
    A A Zverev
    Department of Anatomy, Physiology, and Human Health Protection, Tatar State Humanitarian Pedagogical University, Kazan
    Bull Exp Biol Med 145:174-6. 2008
    ..Selective P2X1 receptor agonist beta,gamma-methylene-ATP induced a dose-dependent increase in the strength of atrial and ventricular ..
  99. ncbi Conserved cysteine residues in the extracellular loop of the human P2X(1) receptor form disulfide bonds and are involved in receptor trafficking to the cell surface
    Steven J Ennion
    Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, United Kingdom
    Mol Pharmacol 61:303-11. 2002
    ..However, trafficking of the receptor to the cell membrane is severely reduced by disruption of the C261-C270 disulfide bond or disruption of C117-C165 together with another bond...
  100. doi P2X(3) expression is not altered by lingual nerve injury
    James E Biggs
    Department of Oral and Maxillofacial Surgery, School of Clinical Dentistry, University of Sheffield, UK
    Neurosci Lett 441:110-4. 2008
    We have investigated a possible role for the ATP receptor subunit P2X(3), in the development of neuropathic pain following injury to a peripheral branch of the trigeminal nerve...
  101. doi The dual nature of extracellular ATP as a concentration-dependent platelet P2X1 agonist and antagonist
    Welvitya Karunarathne
    Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA
    Integr Biol (Camb) 1:655-63. 2009
    ..and inhibition of that aggregation, is affected by free Ca(2+) entering the platelet through the ATP-gated P2X1 receptor. The addition of ATP (10 microM) increased the platelet NO by 26.7 +/- 7.7%...

Research Grants71

  1. TRANSMEMBRANE SIGNALLING IN SMOOTH MUSCLE CELL LINES
    GEORGE DUBYAK; Fiscal Year: 1991
    ..Additional experiments will be directed towards: 1) characterization of the stereo-specificity of the putative ATP receptor; 2) evaluation of the possible relationships between the signalling actions of extracellular ATP and the ..
  2. PURINERGIC NEUROGENIC MUCOSAL SECRETION
    JACKIE WOOD; Fiscal Year: 2007
    ..a novel purinergic slow excitatory postsynaptic potential (EPSP) that is mediated by a metabotropic ATP receptor (P2Y1 receptor) in the enteric nervous system...
  3. PURIFICATION AND CHARACTERIZATION OF ADENOSINE RECEPTORS
    Joel Linden; Fiscal Year: 1993
    ....
  4. P2T PURINERGIC RECEPTORS
    JOSE BOYER; Fiscal Year: 2004
    ..nucleotide effects of platelet function result from the activation of at least three different receptor subtypes: P2X1, P2Y1 and P2Y AC receptors...
  5. NPY AND ATP COTRANMISSION IN CHROMAFFIN CELLS
    TERRY HEXUM; Fiscal Year: 2003
    ..are to characterize the enhancing effect of NPY on ATP- stimulated inositol phosphate formation, identify the ATP receptor subtype mediating the stimulation of InsP formation and increased [Ca2+]i, determine the specificity of the ATP ..
  6. An ATP receptor-operated ionic conductance in Paramecium
    Todd Hennessey; Fiscal Year: 2002
    ..shows ATP-induced behavioral responses (backward swimming), inhibition of these responses by a vertebrate ATP receptor antagonist (PPNDS), ATP-induced depolarizations, high affinity external 3zP-ATP binding and contains membrane ..
  7. SIGNAL TRANSDUCTION BY ATP/UTP RECEPTORS
    GEORGE DUBYAK; Fiscal Year: 1993
    ..Recent physiological, biochemical, and pharmacological studies indicate that there are multiple ATP receptor subtypes: 1) ATP receptors which directly activate cation channels in some excitable cell types; 2) ATP ..
  8. STUDY OF ACTIVITY-DEPENDENT SYMPATHETIC SPROUTING
    Jun Ming Zhang; Fiscal Year: 2010
    ..New reagents for specific ATP receptor subtypes will help investigate its role...
  9. ADENOSINE & KATP CHANNEL CONTROL OF CORONARY BLOOD FLOW
    ERIC FEIGL; Fiscal Year: 2005
    ..The proposed basic research is fundamental to understanding the normal coronary physiology that underlies coronary artery disease. ..
  10. REGULATION OF AIRWAY GOBLET CELL MUCIN RELEASE IN VITRO
    Kwang Kim; Fiscal Year: 1993
    ..by putative antagonists indicate that the action of ATP may be mediated by the recently described P2-type ATP receptor, likely the P2y subtype...
  11. Regulation of Gliosis by Purinergic Receptor Signaling
    W Dalton Dietrich; Fiscal Year: 2006
    ..The objective of this application is to determine how ATP receptor/ERK signaling regulates the commitment to cell cycle progression or growth arrest in astrocytes...
  12. ATP RECEPTORS IN MACROPHAGES AND MONOCYTES
    GEORGE DUBYAK; Fiscal Year: 2000
    ..Our studies indicate that at least four ATP receptor subtypes are differentially expressed in mature phagocytic leukocytes and in myeloid progenitor cells...
  13. Coronary Physiology
    Eric O Feigl; Fiscal Year: 2010
    ..This is a resubmission of RO1 HL 082781-01-A1 (This time as a modular grant.) ..
  14. Coronary Physiology
    ERIC FEIGL; Fiscal Year: 2007
    ..This is a resubmission of RO1 HL 082781-01-A1 (This time as a modular grant.) ..
  15. Regulation of Caspase-1 Signaling and Inflammation by the P2X7 ATP Receptor
    GEORGE DUBYAK; Fiscal Year: 2009
    ..abstract_text> ..
  16. Regulation of Caspase-1 Signaling and Inflammation by the P2X7 ATP Receptor
    George R Dubyak; Fiscal Year: 2010
    ..abstract_text> ..
  17. Regulation of Caspase-1 Signaling and Inflammation by the P2X7 ATP Receptor
    GEORGE DUBYAK; Fiscal Year: 2007
    ....
  18. Molecular Basis for ADP-Induced Platelet Activation
    Satya P Kunapuli; Fiscal Year: 2010
    ..the previous grant periods, we have demonstrated the presence of three ADP receptor subtypes, P2Y1, P2Y12, and P2X1 on platelets and elucidated several signaling mechanisms in platelets...
  19. Platelet ADP receptors
    Satya Kunapuli; Fiscal Year: 2007
    ..During the previous grant period, we have demonstrated 3 ADP receptor subtypes, P2Y1, P2Y12, and P2X1, on platelets and elucidated a number of signaling mechanisms in platelets...
  20. Molecular Basis for ADP-Induced Platelet Activation
    Satya Kunapuli; Fiscal Year: 2006
    ..During the previous grant period, we have demonstrated three ADP receptor subtypes, P2Y1, P2Y12, and P2X1, on platelets and elucidated a number of signaling mechanisms in platelets...