p27

Summary

Gene Symbol: p27
Description: cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Alias: CDKN4, KIP1, MEN1B, MEN4, P27KIP1, cyclin-dependent kinase inhibitor 1B
Species: human

Top Publications

  1. ncbi Angiotensin II regulates the cell cycle of vascular smooth muscle cells from SHR
    A Kubo
    Second Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Am J Hypertens 13:1117-24. 2000
  2. ncbi Rho activity can alter the translation of p27 mRNA and is important for RasV12-induced transformation in a manner dependent on p27 status
    Anxo Vidal
    Programs in Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 277:16433-40. 2002
  3. ncbi p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2
    Isabel Chu
    Braman Family Breast Cancer Institute of the University of Miami Sylvester Comprehensive Cancer Center and Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Cell 128:281-94. 2007
  4. ncbi The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
    Jiyong Liang
    Department of Molecular Therapeutics, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Nat Cell Biol 9:218-24. 2007
  5. ncbi Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation
    Carlos le Sage
    Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    EMBO J 26:3699-708. 2007
  6. ncbi MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma
    F Fornari
    1Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Policlinico S Orsola, Bologna, Italy
    Oncogene 27:5651-61. 2008
  7. ncbi A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors
    Gustavo A Miranda-Carboni
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 22:3121-34. 2008
  8. ncbi C-terminal phosphorylation controls the stability and function of p27kip1
    Uta Kossatz
    Institute for Molecular Biology, Hannover Medical School, Hannover, Germany
    EMBO J 25:5159-70. 2006
  9. ncbi Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase
    Shuhei Kotoshiba
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Fukuoka 812 8582
    J Biol Chem 280:17694-700. 2005
  10. ncbi Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein
    Abdelmajid Sabile
    Institute of Cell Biology, ETH Honggerberg, 8093 Zurich, Switzerland
    Mol Cell Biol 26:5994-6004. 2006

Research Grants

  1. B-RAF Regulation of the Cell Cycle in Melanoma
    Andrew E Aplin; Fiscal Year: 2010
  2. Signaling Pathways in Hepatic Fibrogenesis
    Bruce Bacon; Fiscal Year: 2005
  3. Mechanisms of p27Kipl Proteolysis in Cancer Cells
    Xuedong Liu; Fiscal Year: 2009
  4. Cadherin-PS1-gamma-secretase signal transduction pathway
    NIKOLAOS ROBAKIS; Fiscal Year: 2005
  5. Mechanism of tumor suppression by p27
    Matthew Fero; Fiscal Year: 2003
  6. BREAST INDUCIBLE ANTISENSE CYCLIN D1 TRANSGENIC MICE
    Richard Pestell; Fiscal Year: 2001
  7. Bioflavonoid Effects on EGF Signaling and Cell Cycle Pathways in Prostate Cancer
    Barry Markaverich; Fiscal Year: 2009
  8. Bioflavonoid Effects on EGF Signaling and Cell Cycle Pathways in Prostate Cancer
    BARRY MATTHEW MARKAVERICH; Fiscal Year: 2010
  9. Cell cycle control of vascular remodeling
    RICHARD ASSOIAN; Fiscal Year: 2009
  10. Cell cycle control of vascular remodeling
    RICHARD ASSOIAN; Fiscal Year: 2007

Detail Information

Publications207 found, 100 shown here

  1. ncbi Angiotensin II regulates the cell cycle of vascular smooth muscle cells from SHR
    A Kubo
    Second Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Am J Hypertens 13:1117-24. 2000
    ..Expression of CDK2 inhibitor p27(kip1) mRNA was markedly higher in VSMC from SHR than in cells from WKY rats...
  2. ncbi Rho activity can alter the translation of p27 mRNA and is important for RasV12-induced transformation in a manner dependent on p27 status
    Anxo Vidal
    Programs in Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 277:16433-40. 2002
    The amount of p27(Kip1) establishes a threshold to which G(1) cyclin-cyclin-dependent kinase complexes must surpass prior to cells progressing into S-phase...
  3. ncbi p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2
    Isabel Chu
    Braman Family Breast Cancer Institute of the University of Miami Sylvester Comprehensive Cancer Center and Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Cell 128:281-94. 2007
    The kinase inhibitor p27Kip1 regulates the G1 cell cycle phase. Here, we present data indicating that the oncogenic kinase Src regulates p27 stability through phosphorylation of p27 at tyrosine 74 and tyrosine 88...
  4. ncbi The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
    Jiyong Liang
    Department of Molecular Therapeutics, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Nat Cell Biol 9:218-24. 2007
    ..We present evidence that the cyclin-dependent kinase inhibitor p27(Kip1), is phosphorylated at Thr 198 downstream of the Peutz-Jeghers syndrome protein-AMP-activated protein kinase (LKB1-..
  5. ncbi Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation
    Carlos le Sage
    Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    EMBO J 26:3699-708. 2007
    ..novel functional genetic approach and identified miR-221 and miR-222 (miR-221&222) as potent regulators of p27(Kip1), a cell cycle inhibitor and tumor suppressor...
  6. ncbi MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma
    F Fornari
    1Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Policlinico S Orsola, Bologna, Italy
    Oncogene 27:5651-61. 2008
    ..One proven target of miR-221 is CDKN1B/p27, whose downregulation affects HCC prognosis...
  7. ncbi A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors
    Gustavo A Miranda-Carboni
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 22:3121-34. 2008
    Loss of the CDK inhibitor p27(KIP1) is widely linked with poor prognosis in human cancer...
  8. ncbi C-terminal phosphorylation controls the stability and function of p27kip1
    Uta Kossatz
    Institute for Molecular Biology, Hannover Medical School, Hannover, Germany
    EMBO J 25:5159-70. 2006
    ..Degradation of p27kip1 is known to be a central component of this process as it allows controlled activation of cdk2-associated kinase ..
  9. ncbi Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase
    Shuhei Kotoshiba
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Fukuoka 812 8582
    J Biol Chem 280:17694-700. 2005
    ..We recently identified a novel ubiquitin ligase, KPC (Kip1 ubiquitylation-promoting complex), consisting of KPC1 and KPC2, which regulates the ubiquitin-dependent degradation ..
  10. ncbi Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein
    Abdelmajid Sabile
    Institute of Cell Biology, ETH Honggerberg, 8093 Zurich, Switzerland
    Mol Cell Biol 26:5994-6004. 2006
    Ubiquitin-mediated degradation of the cyclin-dependent kinase inhibitor p27 provides a powerful route for enforcing normal progression through the mammalian cell cycle...
  11. ncbi Inactivation of p27Kip1 by the viral E1A oncoprotein in TGFbeta-treated cells
    A Mal
    Department of Molecular Biology, Cleveland Clinic Research Institute, Ohio 44195, USA
    Nature 380:262-5. 1996
    ..4), inactivation of the cyclin E/A-cdk2 complex by the inhibitory protein p27Kip1 (refs 5-7), and with the accumulation of unphosphorylated retinoblastoma protein...
  12. ncbi High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancers
    Mai Shimada
    Department of Biochemistry 1, Hamamatsu University School of Medicine, Higashi ku, Hamamatsu, Shizuoka, Japan
    Cancer Sci 100:866-72. 2009
    Downregulation of the cyclin-dependent kinase inhibitory protein p27 is frequently observed in various cancers due to enhancement of its degradation...
  13. ncbi A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression
    Pradip K Majumder
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Cell 14:146-55. 2008
    ..In luminal epithelial cells of Akt-driven PIN, we show the concomitant induction of p27(Kip1) and senescence...
  14. ncbi SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
    A C Carrano
    Department of Pathology, New York University Medical Center, New York 10016, USA
    Nat Cell Biol 1:193-9. 1999
    Degradation of the mammalian cyclin-dependent kinase (CDK) inhibitor p27 is required for the cellular transition from quiescence to the proliferative state...
  15. ncbi Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization
    Naoya Fujita
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113 0032, Japan
    J Biol Chem 277:28706-13. 2002
    In many human cancers, the cyclin-dependent kinase inhibitor p27(Kip1) is expressed at low or undetectable levels...
  16. ncbi A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1
    C Spruck
    The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Cell 7:639-50. 2001
    ..Here we demonstrate that Cks1 directs the ubiquitin-mediated proteolysis of the CDK-bound substrate p27Kip1 by the protein ubiquitin ligase (E3) SCF(Skp2)...
  17. ncbi Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity
    M Schreiber
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Oncogene 18:1663-76. 1999
    ..vectors were constructed to overexpress cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 under the control of the murine cytomegalovirus immediate early gene promoter...
  18. ncbi Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase
    Takumi Kamura
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Fukuoka 812 8582, Japan
    Nat Cell Biol 6:1229-35. 2004
    The cyclin-dependent kinase inhibitor p27(Kip1) is degraded at the G0-G1 transition of the cell cycle by the ubiquitin-proteasome pathway...
  19. ncbi [Expression and significance of Ser10 phosphorylated p27(kip1) and JAB1 protein in human hepatocellular carcinoma]
    Mu-Dan Lu
    Zhonghua Bing Li Xue Za Zhi 36:840-1. 2007
  20. ncbi Patterns of expression of cell cycle/apoptosis genes along the spectrum of thyroid carcinoma progression
    Benjamin Saltman
    Department of Otolaryngology, Columbia University College of Physicians and Surgeons, New York, NY 10021, USA
    Surgery 140:899-905; discussion 905-6. 2006
    ..The aim of this study is to determine to what extent cell cycle/apoptosis regulators contribute to cancer progression...
  21. ncbi CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis
    Michael K Connor
    Molecular and Cell Biology, Sunnybrook and Women s College Health Science Centre, 2075 Bayview Ave, Toronto, Ontario, Canada, M4N 3M5
    Mol Biol Cell 14:201-13. 2003
    We show that p27 localization is cell cycle regulated and we suggest that active CRM1/RanGTP-mediated nuclear export of p27 may be linked to cytoplasmic p27 proteolysis in early G1...
  22. ncbi Deregulated degradation of the cdk inhibitor p27 and malignant transformation
    Joanna Bloom
    Department of Pathology and NYU Cancer Instutute, MSB599, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Semin Cancer Biol 13:41-7. 2003
    b>p27 acts as a critical negative regulator of the cell cycle by inhibiting the activity of cyclin/cdk complexes during G0 and G1...
  23. ncbi Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival
    Guang Yang
    Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 8:3419-26. 2002
    ..regulator of G1-S transition and promotes ubiquitin-mediated proteolysis of the cyclin-dependent kinase inhibitor p27. Its overexpression has been implicated in cell transformation and oncogenesis in both in vitro and in vivo models...
  24. ncbi Cytoplasmic localization of Jab1 and p27 Kip1 might be associated with invasiveness of papillary thyroid carcinoma
    Jihyun Ahn
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea
    Endocr J 56:707-13. 2009
    p27(kip1) is a well known negative regulator of cell cycle progression. Jab1 directly binds to p27(kip1) and induces nuclear export and subsequent degradation...
  25. ncbi RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility
    MICHELLE D LARREA
    Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute, University of Miami Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 106:9268-73. 2009
    ..We present evidence that RSK1 drives p27 phosphorylation at T198 to increase RhoA-p27 binding and cell motility...
  26. ncbi Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer
    Giuseppe Viglietto
    Istituto di Endocrinologia ed Oncologia Sperimentale, CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Naples, Italy
    Nat Med 8:1136-44. 2002
    The cyclin-dependent kinase inhibitor p27(kip1) is a putative tumor suppressor for human cancer. The mechanism underlying p27(kip1) deregulation in human cancer is, however, poorly understood...
  27. ncbi Association between the V109G polymorphism of the p27 gene and the risk and progression of oral squamous cell carcinoma
    Guojun Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 10:3996-4002. 2004
    Abnormalities in p27 may alter cell cycle delay required for DNA repair after exposure to carcinogens. A coding exon 1 polymorphism at codon 109 (T-->G) in p27 was identified and thought to have an effect on the functions of its protein...
  28. ncbi Paradoxical expression of cell cycle inhibitor p27 in endometrioid adenocarcinoma of the uterine corpus - correlation with proliferation and clinicopathological parameters
    J Watanabe
    Department of Pathology, Kitasato University School of Medicine, 1 15 1, Kitasato, Sagamihara, Kanagawa, 228 8555, Japan
    Br J Cancer 87:81-5. 2002
    b>p27 is regarded as a cyclin-dependent kinase inhibitor of the G1-to-S cell cycle progression by suppressing the kinase activity of cyclin/cyclin-dependent kinase complex...
  29. ncbi p27-Associated G1 arrest induced by hinokitiol in human malignant melanoma cells is mediated via down-regulation of pRb, Skp2 ubiquitin ligase, and impairment of Cdk2 function
    Shicheng Liu
    Research and Development Department, Nipro Patch Co, Ltd, Kasukabe, Saitama 344 0057, Japan
    Cancer Lett 286:240-9. 2009
    ..Consistent with blocking the G1-S-phase transition, hinokitiol markedly increased p27 protein levels, but caused only a moderate increase in p21, in addition to a decrease in Cdk2, cyclin E, and ..
  30. ncbi Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases
    Matthias Grimmler
    Max Planck Institute of Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Cell 128:269-80. 2007
    b>p27Kip1 controls cell proliferation by binding to and regulating the activity of cyclin-dependent kinases (Cdks). Here we show that Cdk inhibition and p27 stability are regulated through direct phosphorylation by tyrosine kinases...
  31. ncbi A molecularly genetic determination of prognostic factors of the prostate cancer and their relationships to expression of protein p27kip1
    J Dvorackova
    CGB laborator spol s r o Ostrava
    Neoplasma 54:149-54. 2007
    ..their relationship to the prognosis of prostate cancer patients in relation to Gleason score and expression of p27Kip1. We chose a subgroup of 17 monitored patients who had died during five years following diagnosis, and a group of ..
  32. ncbi CDKN1A and CDKN1B polymorphisms and risk of advanced prostate carcinoma
    Adam S Kibel
    Departments of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 63:2033-6. 2003
    ..nucleotide polymorphic variants in the 3'-untranslated region of CDKN1A (p21(cip1)) and in codon 109 of CDKN1B (p27(kip1)) for association with advanced prostate cancer in a European-American population...
  33. ncbi Germline CDKN1B/p27Kip1 mutation in multiple endocrine neoplasia
    Marianthi Georgitsi
    Department of Medical Genetics, University of Helsinki, Finland
    J Clin Endocrinol Metab 92:3321-5. 2007
    ..Recently, a germline mutation in the CDKN1B gene, encoding p27(Kip1), was reported in one suspected MEN1 family with two acromegalic patients.
  34. ncbi Prognostic impact of Skp2 and p27 in human breast cancer
    Frank Traub
    Institue of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625, Hannover, Germany
    Breast Cancer Res Treat 99:185-91. 2006
    ..cycle is controlled by cyclin-dependent kinases and one of the key players is the cyclin-dependent kinase inhibitor p27. The F-box protein Skp2 is a regulator of G1-S transition and promotes specifically the ubiquitin-mediated ..
  35. ncbi Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition
    Irina Nickeleit
    Institute for Molecular Biology, Hannover Medical School, 30625 Hannover, Germany
    Cancer Cell 14:23-35. 2008
    A reduction in the cellular levels of the cyclin kinase inhibitor p27(kip1) is frequently found in many human cancers and correlates directly with patient prognosis...
  36. ncbi p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion
    Gustavo Baldassarre
    Oncologia Sperimentale 2, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Aviano 33081, Italy
    Cancer Cell 7:51-63. 2005
    ..Here, we report that cytoplasmic expression of p27(kip1) affects microtubule (MT) stability following cell adhesion on extracellular matrix (ECM) constituents...
  37. ncbi The V109G polymorphism of the p27 gene CDKN1B indicates a worse outcome in node-negative breast cancer patients
    Thomas Schondorf
    Department of Natural Sciences, University of Applied Sciences Bonn Rhein Sieg, DE 53359 Rheinbach, Germany
    Tumour Biol 25:306-12. 2004
    Although p27 plays a central role in cell cycle regulation, its role in breast cancer prognosis is controversial. Furthermore, the p27 gene CDKN1B carries a polymorphism with unknown functional relevance...
  38. ncbi Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1
    Takayuki Hattori
    Department of Biochemistry 1, Hamamatsu University School of Medicine, Higashi ku, Hamamatsu, Japan
    Cancer Res 67:10789-95. 2007
    The cyclin-dependent kinase inhibitor p27(Kip1) is degraded in late G(1) phase by the ubiquitin-proteasome pathway, allowing cells to enter S phase...
  39. ncbi Variant genotypes of CDKN1A and CDKN1B are associated with an increased risk of breast cancer in Chinese women
    Hongxia Ma
    Laboratory of Reproductive Medicine and Applied Toxicology, Nanjing Medical University, Nanjing, China
    Int J Cancer 119:2173-8. 2006
    p21(Cip1) and p27(Kip1) are cyclin-dependent kinase inhibitors, which can arrest cell proliferation and serve as tumor suppressors...
  40. ncbi A polymorphism in the CDKN1B gene is associated with increased risk of hereditary prostate cancer
    Bao Li Chang
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Res 64:1997-9. 2004
    The loss of cell cycle control is believed to be an important mechanism in the promotion of carcinogenesis. CDKN1B (p27) belongs to the Cip/Kip family and functions as an important cell cycle gatekeeper...
  41. ncbi MicroRNAs (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle
    Rosa Visone
    Dipartimento di Biologia e Patologia Cellulare e Molecolare c o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facolta di Medicina e Chirurgia, Universita degli Studi di Napoli Federico II, Via Pansini, 5, 80131 Naples, Italy
    Endocr Relat Cancer 14:791-8. 2007
    ..Bioinformatic analysis proposed the p27(Kip1) protein, a key regulator of cell cycle, as a candidate target for the miR-221/222 cluster...
  42. ncbi Jun activation domain binding protein 1 expression is associated with low p27(Kip1)levels in node-negative breast cancer
    Francisco J Esteva
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:5652-9. 2003
    ..in breast cancer tissue and adjacent normal tissue, to determine whether JAB1 expression is associated with p27(Kip1) expression in invasive breast carcinomas, and to evaluate the prognostic significance of JAB1 and p27(Kip1) in ..
  43. ncbi Frequent loss of expression of the cyclin-dependent kinase inhibitor p27(Kip1) in estrogen-related Endometrial adenocarcinomas
    Valeria Masciullo
    Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 9:5332-8. 2003
    p27(Kip1) is a member of the Cip1/Kip1 family of cyclin-dependent kinase inhibitors and is a potential tumor suppressor gene...
  44. ncbi Regulation of p27Kip1 by miRNA 221/222 in glioblastoma
    Jana K Gillies
    Ottawa Health Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada
    Cell Cycle 6:2005-9. 2007
    Levels of p27(Kip1), a key negative regulator of the cell cycle, are often decreased in cancer...
  45. ncbi Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states
    Sunita K Agarwal
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1802, USA
    J Clin Endocrinol Metab 94:1826-34. 2009
    ..However, the prevalence of identifiable germline MEN1 mutations in familial MEN1 cases is only 70%. Some cases may have a germline mutation in another gene such as the p27 cyclin-dependent kinase inhibitor (CDKI).
  46. ncbi Low expression of p27(Kip1) is associated with tumor size and poor prognosis in patients with renal cell carcinoma
    Toshiro Migita
    Department of Anatomic Pathology, Kyushu University, Fukuoka, Japan
    Cancer 94:973-9. 2002
    Proliferative activity in tumors depends on regulation of the cell cycle. p27(Kip1) (p27) plays a pivotal role as a negative regulator of the cell cycle...
  47. ncbi Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias
    J A Pietenpol
    Johns Hopkins Oncology Center, Baltimore, Maryland 21231
    Cancer Res 55:1206-10. 1995
    The p27Kip1 (p27) gene encodes an inducible inhibitor of cyclin-dependent kinase activity. Using a murine p27 cDNA as probe, we obtained a human cDNA clone and subsequently used it to isolate a genomic clone of this gene...
  48. ncbi Cyclin E-CDK2 is a regulator of p27Kip1
    R J Sheaff
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center FHCRC, Seattle, Washington 98104, USA
    Genes Dev 11:1464-78. 1997
    ..We show that expression of cyclin E-CDK2 in murine fibroblasts causes phosphorylation of the CDK inhibitor p27Kip1 on T187, and that cyclin E-CDK2 can directly phosphorylate p27 T187 in vitro...
  49. ncbi Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle
    S Coats
    Department of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    Science 272:877-80. 1996
    ..Murine Balb/c-3T3 fibroblasts deprived of serum mitogens accumulated the cyclin-dependent kinase (CDK) inhibitor p27Kip1. This was correlated with inactivation of essential G1 cyclin-CDK complexes and with cell cycle arrest in G1...
  50. ncbi Translational control of p27Kip1 accumulation during the cell cycle
    L Hengst
    Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 271:1861-4. 1996
    ..The p28lck1 protein was shown to be identical to p27Kip1, and the periodic or induced inhibitory activity resulted from a periodic accumulation of the protein...
  51. ncbi p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors
    M V Ponce-Castañeda
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Cancer Res 55:1211-4. 1995
    The p27Kip1 gene codes for a cyclin-dependent kinase inhibitor implicated in G1 arrest by transforming growth factor beta, cell-cell contact, agents that elevate cyclic AMP, and the growth-inhibitory drug rapamycin...
  52. ncbi Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma
    C Cordon-Cardo
    Memorial Sloan Kettering Cancer, New York, NY 10021, USA
    J Natl Cancer Inst 90:1284-91. 1998
    The p27KIP1 gene, whose protein product is a negative regulator of the cell cycle, is a potential tumor suppressor gene; however, no tumor-specific mutations of this gene have been found in humans...
  53. ncbi Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence
    J Lin
    Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Oncogene 20:2000-9. 2001
    ..rat fibroblast, only Cdk6-D3 retains kinase activity due mainly to its ability to evade inhibition by p27(KIP1) and p21(CIP1) with a resemblance to viral cyclin-bound Cdk6...
  54. ncbi Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation
    A Montagnoli
    Department of Pathology and Kaplan Comprehensive Cancer Center, New York University Medical Center, New York, New York 10016, USA
    Genes Dev 13:1181-9. 1999
    The cellular abundance of the cyclin-dependent kinase (Cdk) inhibitor p27 is regulated by the ubiquitin-proteasome system. Activation of p27 degradation is seen in proliferating cells and in many types of aggressive human carcinomas...
  55. ncbi Down-regulation of p27 is associated with malignant transformation and aggressive phenotype of cervical neoplasms
    Lee Wen Huang
    Department of Obstetrics and Gynecology, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Gynecol Oncol 85:524-8. 2002
    b>p27Kip1 (p27) is a member of the cyclin-dependent kinase inhibitor family. The level of p27 protein expression decreases during tumor development and progression in some epithelial tumors...
  56. ncbi Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing
    M Shirane
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 274:13886-93. 1999
    The intracellular level of p27(Kip1), a cyclin-dependent kinase (CDK) inhibitory protein, is rapidly reduced at the G1/S transition phase when the cell cycle pause ceases...
  57. ncbi Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans
    Natalia S Pellegata
    Institutes of Pathology, GSF National Research Center for Environment and Health, 85764 Neuherberg, Germany
    Proc Natl Acad Sci U S A 103:15558-63. 2006
    ..identification of a homozygous frameshift mutation in Cdkn1b, encoding the cyclin-dependent kinase inhibitor p27(Kip1). As a consequence of the mutation, MENX-affected rats show dramatic reduction in p27(Kip1) protein...
  58. ncbi The role of p27Kip1 in proteasome inhibitor induced apoptosis
    Hannes C A Drexler
    Max Planck Institute for Physiological and Clinical Research, Department of Molecular Cell Biology, Bad Nauheim, Germany
    Cell Cycle 2:438-41. 2003
    ..Conflicting results have been reported on the role of the CKI p27Kip1 either in promoting or inhibiting apoptosis mediated by proteasome inhibitors and other drugs...
  59. ncbi The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells
    Lifang Lu
    Department of Cancer Cell Biology, Harvard School of Public Health, Boston, USA
    BMC Cell Biol 3:22. 2002
    The cyclin-dependent kinase inhibitor p27 is a putative tumor suppressor that is downregulated in the majority of human prostate cancers...
  60. ncbi Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex
    A A Russo
    Cellular Biochemistry and Biophysics Program, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York 10021, USA
    Nature 382:325-31. 1996
    The crystal structure of the human p27Kip1 kinase inhibitory domain bound to the phosphorylated cyclin A-cyclin-dependent kinase 2 (Cdk2) complex has been determined at 2.3 angstrom...
  61. ncbi A U-rich element in the 5' untranslated region is necessary for the translation of p27 mRNA
    S S Millard
    Graduate Program in Cell Biology and Genetics, Weill Graduate School of Medical Sciences, Cornell University, New York, New York 10021, USA
    Mol Cell Biol 20:5947-59. 2000
    Increased translation of p27 mRNA correlates with withdrawal of cells from the cell cycle...
  62. ncbi p27(kip1) functional regulation in human cancer: a potential target for therapeutic designs
    B Belletti
    Division of Experimental Oncology, Centro di Riferimento Oncologico, Via Pedemontana Occidentale, 12, Aviano 33081, Italy
    Curr Med Chem 12:1589-605. 2005
    ..The present review will deal with the role of one of this CKI, p27(kip1), in human cancer, focusing in particular on the mechanisms underlying its functional inactivation in tumor cells...
  63. ncbi Loss of cell cycle regulators p27(Kip1) and cyclin E in transitional cell carcinoma of the bladder correlates with tumor grade and patient survival
    J J Del Pizzo
    Division of Urology, Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Pathol 155:1129-36. 1999
    The cyclin-dependent kinase inhibitor p27(Kip1) is a powerful molecular determinant of cell cycle progression. Loss of expression of p27(Kip1) has been shown to be predictive of disease progression in several human malignancies...
  64. ncbi Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels
    Daisuke Morishita
    Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, The University of Tokyo, Tokyo, Japan
    Cancer Res 68:5076-85. 2008
    ..family members (Pim1, Pim2, and Pim3) bind to and directly phosphorylate the cyclin-dependent kinase inhibitor p27(Kip1) at threonine-157 and threonine-198 residues in cells and in vitro...
  65. ncbi Increased apoptosis in differentiating p27-deficient mouse embryonic stem cells
    V Bryja
    Center for Cell Therapy and Tissue Repair, Charles University, V Uvalu 84, 150 06 Prague, Czech Republic
    Cell Mol Life Sci 61:1384-400. 2004
    In mouse embryonic stem (mES) cells, the expression of p27 is elevated when differentiation is induced...
  66. ncbi Kip1 degradation via the ubiquitin-proteasome pathway
    S W Tam
    Mitotix Inc, Cambridge, MA 02139, USA
    Leukemia 11:363-6. 1997
    ..b>Kip1 is a potent inhibitor of Cdks. In quiescent cells Kip1 accumulates without an increase in mRNA or protein synthesis...
  67. ncbi p27kip1 Antisense-induced proliferative activity of rat corneal endothelial cells
    Michiharu Kikuchi
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 45:1763-70. 2004
    To determine whether antisense downregulation of p27(kip1) will overcome G(1)-phase arrest and promote cell cycle progression in rat corneal endothelial cells (CECs).
  68. ncbi Concordant upregulation of type II-TGF-beta-receptor, the cyclin-dependent kinases inhibitor P27Kip1 and cyclin E in human atherosclerotic tissue: implications for lesion cellularity
    C Ihling
    Department of Pathology, University of Freiburg, Germany
    Atherosclerosis 144:7-14. 1999
    ..of TGF-beta-RI and TGF-beta-RII, we investigated the topographical association between TGF-beta-RI, TGF-beta-RII, P27Kip1 and CE by immunohistochemistry in coronary artery segments without atherosclerosis and carotid atheromatous ..
  69. ncbi Aberrant expression of p27(Kip1)-interacting cell-cycle regulatory proteins in ovarian clear cell carcinomas and their precursors with special consideration of two distinct multistage clear cell carcinogenetic pathways
    Sohei Yamamoto
    Department of Basic Pathology, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, 359 8513, Japan
    Virchows Arch 455:413-22. 2009
    We have previously reported that alterations of p27(Kip1)-interacting cell-cycle proteins frequently occur during the development of endometriosis-associated ovarian clear cell adenocarcinoma (CCA; Yamamoto et al...
  70. ncbi Cell cycle dysregulation influences survival in high risk breast cancer patients
    Robert Königsberg
    Third Medical Department, Centre for Oncology and Hematology, CEADDP, Applied Cancer Research, Institution for Translational Research Vienna, and Ludwig Boltzmann Institute for Applied Cancer Research, Vienna, Austria
    Cancer Invest 26:734-40. 2008
    ..studies suggested that dysregulation of cyclin A, cyclin D, cyclin E, p16(ink4), p21(waf1/cip1), and p27(kip1) are of prognostic value in patients with breast cancer...
  71. ncbi Expression of cell cycle proteins in ovarian carcinoma cells in serous effusions-biological and prognostic implications
    B Davidson
    Department of Pathology, The Norwegian Radium Hospital, Oslo, Norway
    Gynecol Oncol 83:249-56. 2001
    ..The aim of this study was to investigate the expression of cell cycle proteins in ovarian carcinoma cells in serous effusions and respective solid tumors...
  72. ncbi Cell cycle regulatory proteins and apoptosis in B-cell chronic lymphocytic leukemia
    D Wolowiec
    Department of Hematology, Medical University, ul Pasteura 4, PL 50 367 Wroclaw, Poland
    Haematologica 86:1296-304. 2001
    ..A particular role in the regulation of these phenomena is played by proteins involved in early G1 phase regulation: pRb kinases: cyclin-dependent kinases (cdk): cdk4 and cdk6 activated by cyclins D, and universal cdk inhibitor p27(Kip1).
  73. ncbi Reduced levels of the cell-cycle inhibitor p27Kip1 in epithelial dysplasia and carcinoma of the oral cavity
    R C Jordan
    Department of Oral Pathology, Faculty of Dentistry, University of Toronto, Ontario, Canada
    Am J Pathol 152:585-90. 1998
    ..Alterations in the cdk inhibitors also appear to be important in cancer development in a number of human tumors. p27Kip1 is a member of the CIP/KIP family of cdk inhibitors that negatively regulates cyclin-cdk complexes...
  74. ncbi Altered expression of cell cycle proteins and prolonged duration of cardiac myocyte hyperplasia in p27KIP1 knockout mice
    R A Poolman
    Cardiovascular Cellular and Molecular Biology, The Rayne Institute, St Thomas Hospital, London, UK
    Circ Res 85:117-27. 1999
    ..We report that loss of p27(KIP1) in the mouse results in a significant increase in heart size and in the total number of cardiac myocytes...
  75. ncbi Expression patterns of cyclins D1, E and cyclin-dependent kinase inhibitors p21waf1/cip1, p27kip1 in colorectal carcinoma: correlation with other cell cycle regulators (pRb, p53 and Ki-67 and PCNA) and clinicopathological features
    E Ioachim
    Department of Pathology, Medical School, University of Ioannina, Ioannina, Greece
    Int J Clin Pract 62:1736-43. 2008
    ..The expression patterns of cyclins D1 and E as well as cyclin-dependent kinase (CDK) inhibitors p21waf1/cip1 and p27kip1 and their interrelationship with other cell cycle checkpoint proteins [p53, pRb, Ki-67 and proliferative cell ..
  76. ncbi p27(Kip1) Knockout mice are protected from diabetic nephropathy: evidence for p27(Kip1) haplotype insufficiency
    Gunter Wolf
    Klinik fur Innere Medizin III, University of Jena, Jena, Germany
    Kidney Int 68:1583-9. 2005
    High glucose up-regulates the mesangial cell expression of p27(Kip1), an inhibitor of cyclin-dependent kinases/cyclin complexes...
  77. ncbi Angiotensin II-induced hypertrophy of proximal tubular cells requires p27Kip1
    Gunter Wolf
    Division of Nephrology and Osteology, Department of Medicine, University of Hamburg, Hamburg, Germany
    Kidney Int 64:71-81. 2003
    ..Ang II also stimulated the expression of p27Kip1, an inhibitor of cyclin-dependent kinases (CDK)...
  78. ncbi Skp2 is an independent prognosticator of gallbladder carcinoma among p27(Kip1)-interacting cell cycle regulators: an immunohistochemical study of 62 cases by tissue microarray
    Shau Hsuan Li
    Division of Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Mod Pathol 20:497-507. 2007
    ..Skp2 and cyclin-dependent kinase subunit 1 (Cks1), are involved in post-transcriptional degradation of p27(Kip1) tumor suppressor, which inhibits both cdk2/cyclin E and cdk2/cyclin A complexes and thus prevents transition to ..
  79. ncbi Cell type-specific induction of cyclin D and cyclin-dependent kinase inhibitor p27(kip1) expression by estrogen in rat endometrium
    Y H Zhuang
    Department of Cell Biology, Tampere University Medical School, 33014, Tampere, Finland
    J Steroid Biochem Mol Biol 78:193-9. 2001
    Cyclins, cyclin-dependent kinases (CDKs) and the CDK inhibitor p27(kip1) are known to be involved in the regulation of G(1)/S phase transition by estrogen in the rodent endometrium...
  80. ncbi p27Kip1 metabolism: a fascinating labyrinth
    Adriana Borriello
    Department of Biochemistry and Biophysics F Cedrangolo, Second University of Naples, Naples, Italy
    Cell Cycle 6:1053-61. 2007
    ..Among the CKIs, p27Kip1 represents a protein of central activity for the control of several phenotypes, including proliferation, ..
  81. ncbi Aberrant expression of p27(Kip1) is associated with malignant transformation of the rat urinary bladder epithelium
    K Ogawa
    First Department of Pathology, Nagoya City University, Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Carcinogenesis 21:117-21. 2000
    ..in reversible hyperplastic and irreversible tumorigenic lesions in the rat urinary bladder, expression of p27(Kip1), cyclin D1 and cyclin E proteins was sequentially compared...
  82. ncbi Hormone-induced proliferation and differentiation of granulosa cells: a coordinated balance of the cell cycle regulators cyclin D2 and p27Kip1
    R L Robker
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 12:924-40. 1998
    ..localization and hormonal regulation of cell cycle activators (cyclin D1, D2, and D3) and cell cycle inhibitors (p27Kip1 and p21Cip1) were analyzed in ovaries of mice and rats at defined stages of follicular growth and differentiation...
  83. ncbi Expression patterns of cyclins D1, E and cyclin-dependent kinase inhibitors p21(Waf1/Cip1) and p27(Kip1) in urothelial carcinoma: correlation with other cell-cycle-related proteins (Rb, p53, Ki-67 and PCNA) and clinicopathological features
    E Ioachim
    Department of Pathology, Medical School, University of Ioannina, Ioannina, Greece
    Urol Int 73:65-73. 2004
    The expression pattern of cyclins D1 and E, as well as cyclin-dependent kinase inhibitors p21(Wa1/Cip1) and p27(Kip1) and their relationship to tumour behaviour and patients' prognosis was examined in 142 urothelial cell carcinomas...
  84. ncbi Posttranslational modifications of p27kip1 determine its binding specificity to different cyclins and cyclin-dependent kinases in vivo
    Wenqing Zhang
    Ludwig Institute for Cancer Research, University College London, 91 Riding House St, London W1W 7BS, United Kingdom
    Blood 105:3691-8. 2005
    ..2D-gel) analysis, we show here that cell-cycle entry is associated with a significant increase in p27(kip1) phosphorylation in human primary B cells...
  85. ncbi Cyclin D1 overexpression induces progestin resistance in T-47D breast cancer cells despite p27(Kip1) association with cyclin E-Cdk2
    E A Musgrove
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria St, Darlinghurst, Sydney, NSW 2010, Australia
    J Biol Chem 276:47675-83. 2001
    ..cyclin expression, induction of p18(INK4c) and increased association of the CDK inhibitors p21(WAF1/Cip1) and p27(Kip1) with cyclin E-Cdk2 have been implicated in these responses...
  86. ncbi High glucose-induced hypertrophy of mesangial cells requires p27(Kip1), an inhibitor of cyclin-dependent kinases
    G Wolf
    University of Hamburg, University Hospital Eppendorf, Department of Medicine, Division of Nephrology and Osteology, Pavilion 61, Martinistrasse 52, D 20246 Hamburg, Germany
    Am J Pathol 158:1091-100. 2001
    ..To further investigate a potential role of p27Kip1 in the development of glucose-induced hypertrophy, mesangial cells from p27Kip1 wild-type (+/+) and knockout (-/-)..
  87. ncbi Cloning and functional expression of a degradation-resistant novel isoform of p27Kip1
    K Hirano
    Department of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem J 353:51-57. 2001
    p27(Kip1) is an inhibitor of cyclin-dependent kinases...
  88. ncbi RANKL coordinates cell cycle withdrawal and differentiation in osteoclasts through the cyclin-dependent kinase inhibitors p27KIP1 and p21CIP1
    Uma Sankar
    Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    J Bone Miner Res 19:1339-48. 2004
    ..that RANKL promoted cell cycle withdrawal of osteoclast precursors dependent on the cyclin kinase inhibitor p27-KIP1, but that both p27-KIP1 and p21-CIP1 were required for osteoclast differentiation...
  89. ncbi Skp2 and p27kip1 expression in melanocytic nevi and melanoma: an inverse relationship
    Qing Li
    Department of Pathology and Laboratory Medicine, Albany Medical College, New Scotland Ave, Albany, NY 12208, USA
    J Cutan Pathol 31:633-42. 2004
    S-phase kinase associated protein-2 (Skp2) ubiquitin ligase p45(SKP2) is important in the degradation of p27kip1 (a cyclin dependent kinase inhibitor) and progression through the G1-S cell-cycle checkpoint...
  90. ncbi Prognostic factors in stage T1 grade 3 bladder cancer survival: the role of G1-S modulators (p53, p21Waf1, p27kip1, Cyclin D1, and Cyclin D3) and proliferation index (ki67-MIB1)
    A Lopez-Beltran
    Department of Pathology, Reina Sofia University Hospital and Cordoba University Medical School, Cordoba, Spain
    Eur Urol 45:606-12. 2004
    ..To determine the prognostic value of a subset of regulators of the transition from G1-to-S phase of cell cycle in stage T1 grade 3 bladder cancers...
  91. ncbi Decreased p27(Kip1) expression and cyclin D1 overexpression, alone and in combination, influence recurrence and survival of patients with resectable extrahepatic bile duct carcinoma
    A M Hui
    Hepato Biliary Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Hepatology 30:1167-73. 1999
    This study was undertaken to identify potential abnormalities of p27(Kip1) and cyclin D1 expression in extrahepatic bile duct carcinomas and to assess the prognostic significance of p27(Kip1) and cyclin D1 levels for patients with this ..
  92. ncbi p27 Kip1 protein expression in Hashimoto's thyroiditis
    G Troncone
    Dipartimento di Scienze Biomorfologiche e Funzionali, University Federico II, 80131 Naples, Italy
    J Clin Pathol 56:587-91. 2003
    Hashimoto's thyroiditis (HT) is an autoimmune disease in which both proliferation and apoptosis are enhanced. p27(Kip1) protein protects tissues from disease mechanisms that involve excessive cell proliferation and apoptosis...
  93. ncbi Focal adhesion kinase (FAK)-dependent regulation of S-phase kinase-associated protein-2 (Skp-2) stability. A novel mechanism regulating smooth muscle cell proliferation
    Mark Bond
    Bristol Heart Institute, University of Bristol, Bristol BS2 8HW, United Kingdom
    J Biol Chem 279:37304-10. 2004
    ..The cyclin-dependent kinase inhibitors, including p27(Kip1), play important roles in maintaining SMC quiescence...
  94. ncbi High Cks1 expression in transgenic and carcinogen-initiated mammary tumors is not always accompanied by reduction in p27Kip1
    Louise Westbrook
    Biochemistry and Molecular Biology Department, Drug Discovery Division, Southern Research Institute, Birmingham, AL 35255, USA
    Int J Oncol 34:1425-31. 2009
    ..role in SCFSkp2-mediated ubiquitination, and consequently turnover, of the cdk2 inhibitor and tumor supressor p27Kip1. High Cks1 expression is associated with aggressive breast tumors and correlates with low p27Kip1 levels in some ..
  95. ncbi EGCG stabilizes p27kip1 in E2-stimulated MCF-7 cells through down-regulation of the Skp2 protein
    Hsiu Chen Huang
    Institute of Biochemistry and Molecular Biology, National Taiwan University Medicine College, Taipei 100, Taiwan
    Endocrinology 149:5972-83. 2008
    Loss of p27Kip1 is associated with a poor prognosis in breast cancer...
  96. ncbi Mutant B-RAF signaling and cyclin D1 regulate Cks1/S-phase kinase-associated protein 2-mediated degradation of p27Kip1 in human melanoma cells
    K V Bhatt
    Center for Cell Biology and Cancer Research, 47 New Scotland Avenue, Albany Medical College, Albany, NY 12208, USA
    Oncogene 26:1056-66. 2007
    ..In melanoma, cyclin D1 is highly expressed and downregulation of the Cdk inhibitor, p27(Kip1), is associated with a poor prognosis...
  97. ncbi PI3K/Akt signaling regulates p27(kip1) expression via Skp2 in PC3 and DU145 prostate cancer cells, but is not a major factor in p27(kip1) regulation in LNCaP and PC346 cells
    Petra W van Duijn
    Department of Pathology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
    Prostate 66:749-60. 2006
    We compared the involvement of PI3K/PTEN/Akt signaling in the regulation of the cell-cycle regulator p27(kip1) and investigated the mechanism of PI3K/PTEN/Akt modulation of p27(kip1) in the prostate cancer cell lines LNCaP, PC346, PC3, ..
  98. ncbi Analysis of cyclin D3-cdk4 complexes in fibroblasts expressing and lacking p27(kip1) and p21(cip1)
    T K Bagui
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida
    Mol Cell Biol 20:8748-57. 2000
    Our studies examined the effects of p27(kip1) and p21(cip1) on the assembly and activity of cyclin D3-cdk4 complexes and determined the composition of the cyclin D3 pool in cells containing and lacking these cyclin-dependent kinase ..
  99. ncbi Forkhead transcription factor FoxO1 transduces insulin-like growth factor's signal to p27Kip1 in primary skeletal muscle satellite cells
    Shuichi Machida
    Department of Biomedical Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    J Cell Physiol 196:523-31. 2003
    ..with the activation of phosphatidylinositol 3'-kinase (PI3K)/Akt and the downregulation of a cell-cycle inhibitor p27Kip1. To understand mechanisms by which IGF-I signals the downregulation of p27Kip1 in rat skeletal satellite cells, ..
  100. ncbi Mechanisms of mitotic inhibition in corneal endothelium: contact inhibition and TGF-beta2
    Nancy C Joyce
    Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 43:2152-9. 2002
    ..Cyclin-dependent kinase inhibitors (CKIs), such as p27kip1 and p15INK4b, help mediate mitotic inhibition in other cell types...
  101. ncbi Defects in retinal pigment epithelium cell proliferation and retinal attachment in mutant mice with p27(Kip1) gene ablation
    Dennis M Defoe
    Department of Anatomy and Cell Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 0582, USA
    Mol Vis 13:273-86. 2007
    ..The present study examines the potential role of the negative cell cycle regulator p27(Kip1) in controlling RPE proliferation, using mice with targeted ablation of the p27(Kip1) gene.

Research Grants73

  1. B-RAF Regulation of the Cell Cycle in Melanoma
    Andrew E Aplin; Fiscal Year: 2010
    ..cells elevates activation of the MEK-ERK1/2 pathway and regulates two key G1 cell cycle proteins: cyclin D1 and p27Kip1. Our preliminary data indicate that mutant B-RAF signaling and cyclin D1 regulate p27Kip1 via expression of Skp2 ..
  2. Signaling Pathways in Hepatic Fibrogenesis
    Bruce Bacon; Fiscal Year: 2005
    ..cell cycle, and is dependent on the balance of positive (cyclins, cyclin-dependent kinases; CDK) and negative (p27Kip1) regulatory cell-cycle proteins...
  3. Mechanisms of p27Kipl Proteolysis in Cancer Cells
    Xuedong Liu; Fiscal Year: 2009
    The cyclin kinase inhibitor p27Kip1 is a potent inhibitor of cell proliferation and plays important roles in the suppression of tumorigenesis in a variety of human cancers...
  4. Cadherin-PS1-gamma-secretase signal transduction pathway
    NIKOLAOS ROBAKIS; Fiscal Year: 2005
    ..of about 20kDa (termed pC20) and regulate expression of both cyclin D1 and cyclin-dependent kinase inhibitor p27Kip1, two important cell cycle proteins. pC20 seems to be derived from a larger cadherin precursor termed pC35...
  5. Mechanism of tumor suppression by p27
    Matthew Fero; Fiscal Year: 2003
    ..Fero to further our understanding of tumor suppression by the cell cycle inhibitor (CKI) gene p27kip1, while making a transition in his career from the position of a mentored researcher to an independent ..
  6. BREAST INDUCIBLE ANTISENSE CYCLIN D1 TRANSGENIC MICE
    Richard Pestell; Fiscal Year: 2001
    ..Activity of the cyclin D1 complex is inhibited by kinase inhibitor proteins including p16Knk4a and p27Kip1. Cyclin D1 levels are increased in 70-100 percent of breast tumor cell lines and the majority of human breast ..
  7. Bioflavonoid Effects on EGF Signaling and Cell Cycle Pathways in Prostate Cancer
    Barry Markaverich; Fiscal Year: 2009
    ..These studies may lead to the development of new drugs and/or dietary components for use in cancer prevention or treatment. ..
  8. Bioflavonoid Effects on EGF Signaling and Cell Cycle Pathways in Prostate Cancer
    BARRY MATTHEW MARKAVERICH; Fiscal Year: 2010
    ..These studies may lead to the development of new drugs and/or dietary components for use in cancer prevention or treatment. ..
  9. Cell cycle control of vascular remodeling
    RICHARD ASSOIAN; Fiscal Year: 2009
    ..find that these positive and negative regulators act largely by controlling levels of the cdk inhibitory protein, p27kip1. Moreover, this convergence is also seen in the regulation of Skp2, the E3 ubiquitin ligase that controls the ..
  10. Cell cycle control of vascular remodeling
    RICHARD ASSOIAN; Fiscal Year: 2007
    ..find that these positive and negative regulators act largely by controlling levels of the cdk inhibitory protein, p27kip1. Moreover, this convergence is also seen in the regulation of Skp2, the E3 ubiquitin ligase that controls the ..
  11. ECM MATRIX, PROTEASE AND MELANOMA PROLIFERATION
    Yves DeClerck; Fiscal Year: 2007
    ..interphase and that this arrest involves a specific up-regulation of the cell cyclin dependent kinase inhibitor p27KIP1 (Henriet et al., PNAS, 97:10026-10031, 2000)...
  12. Regulation of cyclin D3 in B lymphocyte development
    Marcus R Clark; Fiscal Year: 2010
    ..a novel, lymphoid specific mechanism, controls the subnuclear location of cyclin D3 relative to the inhibitor p27kip1 and the CDK4/Rb effector complex...
  13. Physiologic Regulation of Hematopoiesis by Notch
    Nadia Carlesso; Fiscal Year: 2009
    ..activation of SKP2, the F-box subunit of the SCFskp2 complex that targets the cell cycle inhibitors p27Kip1 and p21Cip1 for degradation, promoting their downregulation and the entry into S-phase...
  14. Physiologic Regulation of Hematopoiesis by Notch
    Nadia Carlesso; Fiscal Year: 2010
    ..activation of SKP2, the F-box subunit of the SCFskp2 complex that targets the cell cycle inhibitors p27Kip1 and p21Cip1 for degradation, promoting their downregulation and the entry into S-phase...
  15. Regulation and Role of Ornithine Decarboxylase in Cell Proliferation and Cancer
    John L Cleveland; Fiscal Year: 2010
    ..by selectively affecting Myc's ability to provoke the degradation of the cyclin- dependent kinase inhibitor p27Kip1, a tumor suppressor that inhibits entry and progression through S-phase...
  16. Regulation and Role of Ornithine Decarboxylase in Cell Proliferation and Cancer
    John L Cleveland; Fiscal Year: 2011
    ..by selectively affecting Myc's ability to provoke the degradation of the cyclin- dependent kinase inhibitor p27Kip1, a tumor suppressor that inhibits entry and progression through S-phase...
  17. Regulation of Bladder Smooth Muscle Hyperplasia
    Paul Austin; Fiscal Year: 2007
    ..to varying degrees of resistance to contraction, the candidate has found that the cell cycle control protein p27KIP1 is downregulated by the development of increased tension within the SMC...
  18. MOLECULAR-GENETIC ANALYSIS OF 3P14 GENOMIC STABILITY
    Harry Drabkin; Fiscal Year: 2006
    ..and JAB 1 has also been shown to regulate nuclear-cytoplasmic transport and proteasome-mediated degradation of p27 kip1, which is characteristically abnormal in RCCs and which has been linked to VHL mutations...
  19. Mechanisms of p27Kipl Proteolysis in Cancer Cells
    Xuedong Liu; Fiscal Year: 2010
    Decreased levels of cell cycle inhibitor p27Kip1 due to excessive degradation occur in a variety of aggressive human tumors...
  20. Mechanisms of p27Kipl Proteolysis in Cancer Cells
    Xuedong Liu; Fiscal Year: 2010
    Decreased levels of cell cycle inhibitor p27Kip1 due to excessive degradation occur in a variety of aggressive human tumors...
  21. P27Kipl deficiency, potential promoter of carcinogenesis
    Konstantin Christov Tzelkov; Fiscal Year: 2003
    ..We will examine the feasibility of p27/Kip1 deficiency in transgenic mice for potential use in mammary carcinogenesis studies in chemopreventive studies...
  22. Mechanisms of p27Kip1 Proteolysis in Cancer Cells
    Xuedong Liu; Fiscal Year: 2007
    Abnormally low amounts of the cell cycle inhibitor p27 due to excessive proteolysis are hallmarks of several types of aggressive tumors...
  23. HTLV-I Tax activates the anaphase promoting complex
    Chou Zen Giam; Fiscal Year: 2009
    ..arrested in G1, and enter into a senescence-like state with drastically elevated levels of p21[CIP1/WAF1 and p27[KIP1]...
  24. Gonadotropins & Cox-2 in Ovarian Cancer Prevention
    XIANGXI MIKE XU; Fiscal Year: 2010
    ..Furthermore, addition of oncogenic mutation such as loss of p27kip1 or loss of p53 converts the ovarian adenomas into neoplastic tumors...
  25. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009
    ..showed that the depletion of polyamines in MYCN-amplified NB cells caused G1 cell cycle arrest and affected p27Kip1 levels, retinoblastoma protein Rb phosphorylation, and most intriguingly, blocked MYCN expression, thus providing ..