p230

Summary

Gene Symbol: p230
Description: golgin A4
Alias: CRPF46, GCP2, GOLG, MU-RMS-40.18, p230, 256 kDa golgin, 72.1 protein, centrosome-related protein F46, golgi autoantigen, golgin subfamily a, 4, golgin subfamily A member 4, golgin-240, golgin-245, protein 72.1, trans-Golgi p230
Species: human

Top Publications

  1. pmc African swine fever virus causes microtubule-dependent dispersal of the trans-golgi network and slows delivery of membrane protein to the plasma membrane
    Christopher L Netherton
    Pirbright Laboratory, Institute for Animal Health, Ash Road, Pirbright, Surrey GU24 0NF, United Kingdom
    J Virol 80:11385-92. 2006
  2. ncbi Physiological and genetic characteristics of two bacterial strains utilizing phenoxypropionate and phenoxyacetate herbicides
    R H Muller
    UFZ Centre for Environmental Research, Department of Environmental Microbiology, Leipzig, Germany
    Microbiol Res 156:121-31. 2001
  3. doi Eukaryotic GCP1 is a conserved mitochondrial protein required for progression of embryo development beyond the globular stage in Arabidopsis thaliana
    Kirsten Haussuehl
    QIAGEN GmbH, Qiagen Strasse 1, DE 40724 Hilden, Germany
    Biochem J 423:333-41. 2009
  4. ncbi Identification of TFIID components required for transcriptional activation by upstream stimulatory factor
    T Kokubo
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:17554-8. 1993
  5. pmc Interaction between the N-terminal domain of the 230-kDa subunit and the TATA box-binding subunit of TFIID negatively regulates TATA-box binding
    T Kokubo
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 91:3520-4. 1994
  6. doi Isolation of two Locust protein targets of a protein tyrosine phosphatase from Metarhizium anisopliae strain CQMa102
    Zhenlun Li
    Genetic Engineering Research Center, Bioengineering College, Chongqing University, Chongqing 400030, China
    J Invertebr Pathol 99:151-5. 2008
  7. ncbi GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network
    Michael R Luke
    Russell Grimwade School of Biochemistry and Molecular Biology, The University of Melbourne, Victoria 3010, Australia
    J Biol Chem 278:4216-26. 2003
  8. ncbi Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl: longer disease latency, thrombocytosis, and mild leukocytosis
    Koiti Inokuchi
    Division of Hematology, Department of Internal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Blood 102:320-3. 2003
  9. ncbi TaqMan RT-PCR assay coupled with capillary electrophoresis for quantification and identification of bcr-abl transcript type
    Rajyalakshmi Luthra
    Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    Mod Pathol 17:96-103. 2004
  10. ncbi [A geometrical model for the perceived line of orientation based on subjective evaluations and human VEP data]
    Ch A Izmailov
    Lomonosov State University, Moscow
    Zh Vyssh Nerv Deiat Im I P Pavlova 54:237-49. 2004

Research Grants

Scientific Experts

Detail Information

Publications132 found, 100 shown here

  1. pmc African swine fever virus causes microtubule-dependent dispersal of the trans-golgi network and slows delivery of membrane protein to the plasma membrane
    Christopher L Netherton
    Pirbright Laboratory, Institute for Animal Health, Ash Road, Pirbright, Surrey GU24 0NF, United Kingdom
    J Virol 80:11385-92. 2006
    ..Golgin p230 and TGN46 are separated into distinct vesicles, whereupon TGN46 is depleted...
  2. ncbi Physiological and genetic characteristics of two bacterial strains utilizing phenoxypropionate and phenoxyacetate herbicides
    R H Muller
    UFZ Centre for Environmental Research, Department of Environmental Microbiology, Leipzig, Germany
    Microbiol Res 156:121-31. 2001
    Two strains, Rhodoferax sp. P230 and Delftia (Comamonas) acidovorans MCI, have previously been shown to carry activities for the degradation of the two enantiomers of (RS)-2-(2,4-dichlorophenoxy-)propionate (dichlorprop) and (RS)-2-(4-..
  3. doi Eukaryotic GCP1 is a conserved mitochondrial protein required for progression of embryo development beyond the globular stage in Arabidopsis thaliana
    Kirsten Haussuehl
    QIAGEN GmbH, Qiagen Strasse 1, DE 40724 Hilden, Germany
    Biochem J 423:333-41. 2009
    ..Our survey of genome databases revealed that all eukaryotic organisms contain two GCP genes [called GCP1 and GCP2/Kae1 (kinase-associated endopeptidase 1)], whereas prokaryotes have only one, either of the GCP1- (Bacteria) or the ..
  4. ncbi Identification of TFIID components required for transcriptional activation by upstream stimulatory factor
    T Kokubo
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:17554-8. 1993
    ..the relevance of the Drosophila TFIID components identified in this analysis, including the previously unrecognized p230 (Dynlacht, B. D., Hoey, T., and Tjian, R...
  5. pmc Interaction between the N-terminal domain of the 230-kDa subunit and the TATA box-binding subunit of TFIID negatively regulates TATA-box binding
    T Kokubo
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 91:3520-4. 1994
    ..Previously, the largest subunit of TFIID (p230) was cloned and demonstrated to inhibit the TATA-box binding of TBP in the absence of other subunits...
  6. doi Isolation of two Locust protein targets of a protein tyrosine phosphatase from Metarhizium anisopliae strain CQMa102
    Zhenlun Li
    Genetic Engineering Research Center, Bioengineering College, Chongqing University, Chongqing 400030, China
    J Invertebr Pathol 99:151-5. 2008
    ..migratoria hemolymph. One phosphoprotein was identified as trans-Golgi p230. Previous studies have shown that trans-Golgi p230 participates in vesicular transport of functional proteins from ..
  7. ncbi GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network
    Michael R Luke
    Russell Grimwade School of Biochemistry and Molecular Biology, The University of Melbourne, Victoria 3010, Australia
    J Biol Chem 278:4216-26. 2003
    ..Previously we demonstrated that the GRIP domain of p230/golgin245 is specifically recruited to tubulovesicular structures of the trans-Golgi network (TGN)...
  8. ncbi Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl: longer disease latency, thrombocytosis, and mild leukocytosis
    Koiti Inokuchi
    Division of Hematology, Department of Internal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Blood 102:320-3. 2003
    b>P230 Bcr/Abl has been associated with indolent myeloproliferative disease (MPD)...
  9. ncbi TaqMan RT-PCR assay coupled with capillary electrophoresis for quantification and identification of bcr-abl transcript type
    Rajyalakshmi Luthra
    Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    Mod Pathol 17:96-103. 2004
    ..1 (e1), 13 (b2), or 14 (b3), or rarely to exon 19 (e19) of bcr resulting in chimeric proteins of p190, p210 and p230, respectively...
  10. ncbi [A geometrical model for the perceived line of orientation based on subjective evaluations and human VEP data]
    Ch A Izmailov
    Lomonosov State University, Moscow
    Zh Vyssh Nerv Deiat Im I P Pavlova 54:237-49. 2004
    ..the activity of the first channel affects the interpeak amplitudes of both the P1-N2 (P130-N180) and N2-P2 (N180-P230) components, whereas the second channel affects only the late component N180-P230...
  11. ncbi Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex
    L W McMahon
    Department of Pathology, University of Medicine and Dentistry New Jersey Medical School, Newark, New Jersey 07103, USA
    J Biol Chem 274:32904-8. 1999
    ..The FANCA gene appears to play a role in the stability or expression of this protein. We now show that p230 is a well known structural protein, human alpha spectrin II (alphaSpIISigma*), and that levels of alphaSpIISigma* ..
  12. pmc Arfaptins are localized to the trans-Golgi by interaction with Arl1, but not Arfs
    Zhiqiu Man
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    J Biol Chem 286:11569-78. 2011
    ..with Arl1 through their BAR domain-containing region and compete for Arl1 binding with golgin-97 and golgin-245/p230, both of which also bind to Arl1 through their GRIP (golgin-97/RanBP2/Imh1p/p230) domains...
  13. ncbi Early endosomes, late endosomes, and lysosomes display distinct partitioning strategies of inheritance with similarities to Golgi-derived membranes
    Kate Dunster
    Department of Pathology and Immunology, Monash Medical School, Prahran, Victoria, Australia
    Eur J Cell Biol 81:117-24. 2002
    ..We conclude a portion of endosomal compartments and Golgi-derived membranes undergo ordered partitioning based on the centrosome and mitotic spindle...
  14. doi Microtubule and katanin-dependent dynamics of microtubule nucleation complexes in the acentrosomal Arabidopsis cortical array
    Masayoshi Nakamura
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma 630 0192, Japan
    Nat Cell Biol 12:1064-70. 2010
    ..We visualized the dynamics of two fluorescently-tagged γ-tubulin complex proteins, GCP2 and GCP3, in Arabidopsis thaliana...
  15. ncbi The semantic component of the evoked potential of differentiation
    Chingis A Izmailov
    Moscow State University, Russia
    Span J Psychol 11:323-42. 2008
    ..is reflected in the occipital and temporal leads to an identical extent, but only in the amplitude of a later (N180-P230) component of the EPD...
  16. ncbi Cytogenetic and molecular genetic aspects of chronic myeloid leukaemia
    David J Barnes
    Department of Haematology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, UK
    Acta Haematol 108:180-202. 2002
    ..disease phenotypes are associated with each of the three Bcr-Abl oncoproteins, p190(Bcr-Abl), p210(Bcr-Abl )and p230(Bcr-Abl)...
  17. ncbi Cloning and genomic localization of the murine LPS-induced CXC chemokine (LIX) gene, Scyb5
    Jeffrey B Smith
    Pediatrics Neonatology B2 325, MDCC, David Geffen School of Medicine and Mattel Children s Hospital at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1752, USA
    Immunogenetics 54:599-603. 2002
    ..The sequence and mapping data suggest that the human ENA78-PBP-PF4 and GCP2- psi PBP-PF4V1 loci arose from an evolutionarily recent duplication of an ancestral locus related to the murine Lix-..
  18. doi Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis
    Yasser El-Hawari
    Institute of Toxicology and Pharmacology for Natural Scientists, University Medical School Schleswig Holstein, Kiel, Germany
    Chem Biol Interact 178:234-41. 2009
    ..In particular, when nine residues (236-244) in the vicinity of the catalytic center and a proline (P230) in CBR3 were mutated to the corresponding residues of CBR1 a much higher k(cat)/K(m) value (5...
  19. ncbi Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells
    Claudia Zahn
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Mol Membr Biol 23:475-85. 2006
    ..These data suggest that lethality of Arfrp1 knockout embryos is due to a specific disruption of protein targeting, e.g., of ARL1 and Golgin-245, to the Golgi...
  20. ncbi The phosphotriesterase gene opdA in Agrobacterium radiobacter P230 is transposable
    Irene Horne
    CSIRO Entomology, GPO Box 1700, Canberra, ACT 2601, Australia irene horne
    FEMS Microbiol Lett 222:1-8. 2003
    We report a transposase gene (tnpA) upstream of the opdA phosphotriesterase gene of Agrobacterium radiobacter P230, as well as inverted repeats indicative of insertion sequences, flanking the two genes...
  21. ncbi Deletion mapping using quantitative real-time PCR identifies two distinct 3p21.3 regions affected in most cervical carcinomas
    Vera Senchenko
    Microbiology and Tumor Biology Center, Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, 17177 Sweden
    Oncogene 22:2984-92. 2003
    ..The results strongly suggest that 3p21.3T and 3p21.3C regions harbor genes involved in the origin and/or development of CCs and imply that those genes might be multiple TSG(s)...
  22. ncbi Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus
    Bojana Panic
    MRC Laboratory of Molecular Biology, MRC Centre, Hills Road, Cambridge CB2 2QH, United Kingdom
    Mol Cell 12:863-74. 2003
    ..Despite no conservation of sequence, topology, or even helical direction, several other effectors form similar interactions with small GTPases via a pair of alpha helices, suggesting a common structural basis for effector recognition...
  23. pmc Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70
    Kai feng Xu
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:2784-9. 2005
    ..In cells incubated with brefeldin A, most of the BIG2, Exo70, and trans-Golgi protein p230 were widely dispersed from their perinuclear concentrations, but small amounts always remained, apparently at the ..
  24. pmc Giantin is the major Golgi autoantigen in human anti-Golgi complex sera
    Kazuhisa Nozawa
    Department of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, USA
    Arthritis Res Ther 6:R95-102. 2004
    ..The stable association of giantin with the putative released Golgi complex may contribute to its preferential autoantigenicity...
  25. doi Molecular modeling reveals binding interface of γ-tubulin with GCP4 and interactions with noscapinoids
    Charu Suri
    Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan, 173234, Himachal Pradesh, India
    Proteins 83:827-43. 2015
    ..e., GCP2, GCP3, GCP4, GCP5, and GCP6...
  26. ncbi ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins
    H Van Valkenburgh
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322 3050, USA
    J Biol Chem 276:22826-37. 2001
    ..These data reveal a complex network of interactions between GTPases in the ARF family and their effectors and reveal a potential for cross-talk not demonstrated previously...
  27. pmc Activation of the γ-tubulin complex by the Mto1/2 complex
    Eric M Lynch
    Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Swann Building, Mayfield Road, Edinburgh EH9 3JR, UK
    Curr Biol 24:896-903. 2014
    ..microtubules in vivo, we further determine the number and stoichiometry of Mto1, Mto2, and γ-TuC subunits Alp4 (GCP2) and Alp6 (GCP3) within active nucleation complexes...
  28. pmc Rab6a/a' are important Golgi regulators of pro-inflammatory TNF secretion in macrophages
    Massimo Micaroni
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
    PLoS ONE 8:e57034. 2013
    ..In live cells, Rab6-GFP were localized on trans-Golgi network (TGN)-derived tubular carriers demarked by the golgin p230. Rab6 depletion and inactive mutants altered carrier egress and partially reduced p230 membrane association...
  29. doi Triesterase and promiscuous diesterase activities of a di-Co(II)-containing organophosphate degrading enzyme reaction mechanisms
    Marta E Alberto
    Dipartimento di Chimica e Tecnologie Chimiche and Centro di Calcolo ad Alte Prestazioni per Elaborazioni Parallele e Distribuite Centro d Eccellenza MIUR, Universita della Calabria, 87036 Arcavacata di Rende CS Italy
    Chemistry 21:3736-45. 2015
    ..phosphodiester by the di-Co(II) derivative of organophosphate degrading enzyme from Agrobacterium radiobacter P230(OpdA), have been investigated at density functional level of theory in the framework of the cluster model approach...
  30. pmc Microtubule Reorganization during Mitosis and Cytokinesis: Lessons Learned from Developing Microgametophytes in Arabidopsis Thaliana
    Bo Liu
    Department of Plant Biology, University of California Davis, CA, USA
    Front Plant Sci 2:27. 2011
    ..However, a number of mutations like gem1, gcp2, and nedd1 can be maintained in heterozygous mutants in Arabidopsis thaliana...
  31. pmc MicroRNA and mRNA cargo of extracellular vesicles from porcine adipose tissue-derived mesenchymal stem cells
    Alfonso Eirin
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States
    Gene 551:55-64. 2014
    ..These observations may contribute to development of regenerative strategies using EVs to overcome potential complications of cell-based therapy...
  32. ncbi [Functional arrangement of genomic DNA and structure of nuclear matrix]
    Y Hibino
    School of Medicine, Toyama Medical and Pharmaceutical University, Japan
    Yakugaku Zasshi 120:520-33. 2000
    ..We have shown that an MAR binding protein, P230, is detectable in rat hepatoma cells but not in normal liver, and suggested that this protein is a diagnostic and ..
  33. pmc The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p
    S M Murphy
    Department of Biological Sciences, Stanford University, Stanford, California
    J Cell Biol 141:663-74. 1998
    ..b>GCP2 and GCP3 colocalize with gamma-tubulin at the centrosome, cosediment with gamma-tubulin in sucrose gradients, and ..
  34. doi Novel spectrophotometric methods for simultaneous determination of Amlodipine, Valsartan and Hydrochlorothiazide in their ternary mixture
    Hayam M Lotfy
    Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El Aini Street, 11562 Cairo, Egypt
    Spectrochim Acta A Mol Biomol Spectrosc 140:495-508. 2015
    ..applying successive derivative subtraction they were obtained in their first derivative spectra and determined at P230.8-246, P261.4-278.2, P233.7-246.8 for AML, HCT and VAL respectively...
  35. pmc Analysis of the human immunodeficiency virus type 1 M group Vpu domains involved in antagonizing tetherin
    Sarah J Petit
    MRC Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, Cruciform Building, 90 Gower Street, London WC1E 6BT, UK
    J Gen Virol 92:2937-48. 2011
    ..This work sheds light on the acquisition of anti-tetherin activity and the molecular details of pandemic HIV infection in humans...
  36. ncbi A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins
    L Kjer-Nielsen
    Department of Pathology and Immunology, Monash University Medical School, Melbourne, Victoria, Australia 3181
    Curr Biol 9:385-8. 1999
    ..Previously, we have identified a carboxy-terminal domain of the trans-Golgi-network (TGN) protein p230 that is responsible for Golgi localisation [1]...
  37. ncbi Leukemogenesis of b2a2-type p210 BCR/ABL in a bone marrow transplantation mouse model using a lentiviral vector
    Naoya Uchida
    Department of Molecular and Medical Genetics, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 76:134-47. 2009
    The BCR/ABL fusion oncogene found in Philadelphia-positive leukemia exists in three principle forms: p190, p210 and p230. P210 BCR/ABL is commonly found in patients with chronic myelogenous leukemia (CML) and is further categorized into ..
  38. ncbi Thin is better!: ultrathin cryosection immunocytochemistry
    Toshihiro Takizawa
    Department of Anatomy, Nippon Medical School, 1 1 5 Sendagi, Bunnkyo ku, Tokyo 113 8602, Japan
    J Nippon Med Sch 71:306-7. 2004
    ..Cryosections were incubated with mouse anti-p230, a trans-Golgi network marker, and subsequently incubated with Alexa 488-labeled goat anti-mouse IgG or with goat ..
  39. ncbi Age-related differences in neuromagnetic brain activity underlying concurrent sound perception
    Claude Alain
    Rotman Research Institute, Baycrest Centre for Care, Toronto, Ontario, Canada M6A 2E1
    J Neurosci 27:1308-14. 2007
    ..140-180 ms) that overlapped the N1 and P2 waves, and a positive displacement that peaked at approximately 230 ms (P230) after sound onset...
  40. ncbi tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre
    Atsuko Yoshino
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6082, USA
    J Cell Sci 118:2279-93. 2005
    tGolgin-1 (trans-Golgi p230, golgin-245) is a member of a family of large peripheral membrane proteins that associate with the trans-Golgi network (TGN) via a C-terminal GRIP domain...
  41. doi Trans-Golgi protein p230/golgin-245 is involved in phagophore formation
    Miwa Sohda
    Division of Oral Biochemistry, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata 951 8514, Japan
    Biochem Biophys Res Commun 456:275-81. 2015
    b>p230/golgin-245 is a trans-Golgi coiled-coil protein that is known to participate in regulatory transport from the trans-Golgi network (TGN) to the cell surface...
  42. doi Resistance of human butyrylcholinesterase to methylene blue-catalyzed photoinactivation; mass spectrometry analysis of oxidation products
    Ozden Tacal
    Department of Biochemistry, School of Pharmacy, Hacettepe University, Ankara, Turkey
    Photochem Photobiol 89:336-48. 2013
    ..412, 490, 522), oxidized methionine (M81, 144, 302, 532, 554, 555), oxidized histidine (H214), oxidized proline (P230), oxidized cysteine (C519) and oxidized serine (S215)...
  43. pmc The {gamma}-tubulin complex protein GCP4 is required for organizing functional microtubule arrays in Arabidopsis thaliana
    Zhaosheng Kong
    Department of Plant Biology, University of California, Davis, California 95616, USA
    Plant Cell 22:191-204. 2010
    ..and organization depend on the evolutionarily conserved protein gamma -tubulin, which forms a complex with GCP2-GCP6 (GCP for gamma -Tubulin Complex Protein)...
  44. pmc GTPase ARFRP1 is essential for normal hepatic glycogen storage and insulin-like growth factor 1 secretion
    Deike Hesse
    Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Mol Cell Biol 32:4363-74. 2012
    ..Our data indicate that ARFRP1 in the liver is involved in the regulation of IGF1 secretion and GLUT2 sorting and is thereby essential for normal growth and glycogen storage...
  45. doi Clonal evolution with double Ph followed by tetraploidy in imatinib-treated chronic myeloid leukemia with e19a2 transcript in transformation
    Gaku Oshikawa
    Department of Hematology, Tokyo Medical and Dental University, Bunkyoku, Japan
    Cancer Genet Cytogenet 199:56-61. 2010
    Chronic myeloid leukemia (CML) with the e19a2 transcript coding for p230 is typically associated with a benign clinical course unless accompanied at presentation with additional chromosomal abnormalities...
  46. ncbi Effect of glutamate carboxypeptidase II and reduced folate carrier polymorphisms on folate and total homocysteine concentrations in dialysis patients
    Manuela Fodinger
    Institute of Medical and Chemical Laboratory Diagnostics, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Am Soc Nephrol 14:1314-9. 2003
    ..nucleotide polymorphisms in the reduced folate carrier 1 (RFC1 80G>A) and the glutamate carboxypeptidase 2 (GCP2 1561C>T) gene on total homocysteine (tHcy) plasma level and folate status in 120 chronic dialysis patients...
  47. ncbi [Screening of proteins binding to FXR1P using yeast two-hybrid technique]
    Jiao Su
    Department of Biochemistry, Changzhi Medical College, Changzhi 046000, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:2394-6, 2400. 2009
    ..To screen the proteins interacting with FXR1P for functional investigation of FXR1P...
  48. ncbi The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure
    Merran C Derby
    Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria 3010, Australia, and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria 3010, Australia
    Traffic 8:758-73. 2007
    ..The TGN golgins, p230/golgin-245 and golgin-97, are recruited via the GTPase Arl1, whereas the TGN golgin GCC185 is recruited ..
  49. ncbi The GRIP domain - a novel Golgi-targeting domain found in several coiled-coil proteins
    S Munro
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH
    Curr Biol 9:377-80. 1999
    ..In this paper, we show that two other mammalian Golgi coiled-coil proteins, golgin-245/p230 and golgin-97, have a conserved domain of about 50 amino acids at their carboxyl termini...
  50. ncbi Effects of distraction on pain-related somatosensory evoked magnetic fields and potentials following painful electrical stimulation
    H Yamasaki
    Department of Integrative Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan
    Brain Res Cogn Brain Res 9:165-75. 2000
    ..In the SEP recording, the middle-latency components (N140 and P230) were identified as being maximal around the vertex...
  51. pmc CDK5RAP2 stimulates microtubule nucleation by the gamma-tubulin ring complex
    Yuk Kwan Choi
    Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, China
    J Cell Biol 191:1089-95. 2010
    ..TuRC bound to γ-TuNA contains NME7, FAM128A/B, and actin in addition to γ-tubulin and GCP2-6...
  52. doi Functional replacement of fission yeast γ-tubulin small complex proteins Alp4 and Alp6 by human GCP2 and GCP3
    Timothy D Riehlman
    College of Nanoscale Science and Engineering, State University of New York SUNY, Nanobioscience, Albany, NY12203, USA
    J Cell Sci 126:4406-13. 2013
    ..that GCP3/Spc98 function is fully conserved with Alp6 across species but that functional differences exist between GCP2/Spc97 and Alp4...
  53. ncbi Antiangiogenic gene therapy of myeloproliferative disease developed in transgenic mice expressing P230 bcr/abl
    K Miyake
    Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan
    Gene Ther 12:541-5. 2005
    ..We have recently produced transgenic mice expressing P230 bcr/abl that develop myeloproliferative disease (MPD) closely resembling human chronic myelogenous leukemia...
  54. pmc Effects of {gamma}-tubulin complex proteins on microtubule nucleation and catastrophe in fission yeast
    Sabina Zimmerman
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Mol Biol Cell 16:2719-33. 2005
    ..Here, we investigated gamma-TuC function by analyzing MT behavior in mto1Delta and alp4 (GCP2 homologue) mutants...
  55. ncbi N-substituted 4-aminobenzamides (procainamide analogs): an assessment of multiple cellular effects concerning ion trapping
    Guillaume Morissette
    Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Quebec, 2705 Laurier Blvd, Quebec, QC, Canada G1V 4G2
    Mol Pharmacol 68:1576-89. 2005
    ..Giant vacuole formation, of confirmed trans-Golgi origin (labeled with C5-ceramide, p230, golgin-97), is a cellular response to all tested amines in the series (> or = 2.5 mM), including triethylamine...
  56. ncbi Autoantibodies to protein transport and messenger RNA processing pathways: endosomes, lysosomes, Golgi complex, proteasomes, assemblyosomes, exosomes, and GW bodies
    Laura M Stinton
    Faculty of Medicine, University of Calgary, Calgary, AB, Canada
    Clin Immunol 110:30-44. 2004
    ..Current evidence suggests that GWBs are involved in the cytoplasmic processing of mRNAs. Autoantibodies to the "cytoplasmic somes" are relatively uncommon and serological tests to detect most of them are not widely available...
  57. pmc Differential effects of depletion of ARL1 and ARFRP1 on membrane trafficking between the trans-Golgi network and endosomes
    Kirika Nishimoto-Morita
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 284:10583-92. 2009
    ..Furthermore, we have obtained evidence suggesting that a SNARE complex containing Vti1a, syntaxin 6, and syntaxin 16 is involved in Shiga toxin transport downstream of ARL1...
  58. pmc Characterization of the different BCR-ABL transcripts with a single multiplex RT-PCR
    Jacques Chasseriau
    Laboratoire de Genetique Cellulaire et Moleculaire, UPRES EA2622, Poitiers Cedex, France
    J Mol Diagn 6:343-7. 2004
    ..Identification of the transcript (p190, p210 or p230) does not reveal the type of junction but this information is very important for classification of patients in ..
  59. ncbi Combination with an antisense oligonucleotide synergistically improves the antileukemic efficacy of erucylphospho-N,N,N-trimethylpropylammonium in chronic myeloid leukemia cell lines
    Spiro M Konstantinov
    Unit of Toxicology and Chemotherapy, German Cancer Research Center, 69120 Heidelberg, Germany
    Mol Cancer Ther 1:877-84. 2002
    ..01). AR-230 cells that express high levels of p230(BCR-ABL) showed an intermediate decrease in colony formation in response to the ASO-bcr (T/C%, 20; P < 0.05)...
  60. ncbi Bcr-Abl variants: biological and clinical aspects
    Anjali S Advani
    Departments of Hematology and Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Leuk Res 26:713-20. 2002
    ..Three different Bcr-Abl variants can be formed, depending on the amount of Bcr gene included: p185, p210, and p230. The three variants are associated with distinct types of human leukemias...
  61. ncbi Targeting of the GRIP domain to the trans-Golgi network is conserved from protists to animals
    Malcolm J McConville
    Russell Grimwade School of Biochemistry and Molecular Biology, University of Melbourne, Victoria, Australia
    Eur J Cell Biol 81:485-95. 2002
    ..GFP fusion proteins containing either the T. brucei GRIP domain or the human p230 GRIP (p230GRIP) domain were also expressed in the trypanosomatid parasite, Leishmania mexicana, and localized by ..
  62. pmc The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium
    Alexander Jaschke
    Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam Rehbruecke, D 14558 Nuthetal, Germany
    Hum Mol Genet 21:3128-42. 2012
    ..Thus, the GTPase ARFRP1 and its downstream proteins are required for the lipidation of chylo-microns and the assembly of ApoA-I to these particles in the Golgi of intestinal epithelial cells...
  63. doi Arabidopsis GCP3-interacting protein 1/MOZART 1 is an integral component of the γ-tubulin-containing microtubule nucleating complex
    Masayoshi Nakamura
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630 0192, Japan
    Plant J 71:216-25. 2012
    ..a pattern largely consistent with, but partly distinct from, the localization of the γ-tubulin complex containing GCP2 or GCP3 in planta...
  64. doi Prenatal stress alters dendritic morphology and synaptic connectivity in the prefrontal cortex and hippocampus of developing offspring
    Richelle Mychasiuk
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada
    Synapse 66:308-14. 2012
    The current study used stereological techniques in combination with Golg-Cox methods to examine the neuroanatomical alterations in the prefrontal cortex and hippocampus of developing offspring exposed to gestational stress...
  65. pmc In vivo analysis of the functions of gamma-tubulin-complex proteins
    Yi Xiong
    Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Cell Sci 122:4218-27. 2009
    ..proteins (GCPs), we identified and analyzed the functions of the Aspergillus nidulans homologs of GCP2-GCP6 (here designated GCPB-GCBF)...
  66. pmc Cell edges accumulate gamma tubulin complex components and nucleate microtubules following cytokinesis in Arabidopsis thaliana
    Chris Ambrose
    Department of Botany, The University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 6:e27423. 2011
    ..Here we use live imaging to show that components of the gamma tubulin nucleation complex (GCP2 and GCP3) localize at distinct sites along the outer periclinal edge of newly formed crosswalls, and that ..
  67. doi An interstitial deletion at 3p21.3 results in the genetic fusion of MLH1 and ITGA9 in a Lynch syndrome family
    Claus Meyer
    Institute of Pharmaceutical Biology Diagnostic Center for Acute Leukemia Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit Cluster of Excellence Frankfurt, Biocenter, Goethe University Frankfurt, Frankfurt Main, Germany
    Clin Cancer Res 15:762-9. 2009
    ..Here, we describe the discovery and first functional characterization of a novel germline MLH1 mutant allele...
  68. doi In vivo study of response threshold in retinal degenerate model at different degenerate stages
    L H Chan
    Biomedical Engineering Department, University of Southern California, Los Angeles 90033, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:1781-4. 2008
    ..180 degenerate groups, threshold currents were not significantly different from the normal control group (P90 and P230). For P300 degenerate group, the threshold currents progressively increased...
  69. doi Baclofen does not counteract the acute effects of ethanol on flash-evoked potentials in Long-Evans rats
    Bruce E Hetzler
    Department of Psychology, Lawrence University, Appleton, Wisconsin 54912, USA
    Int J Neurosci 118:1558-81. 2008
    ..P47, N62, and P87, but very similar to baclofen alone for primary component N31 and late components N147 and P230. In the SC, component amplitudes were generally decreased by ethanol, baclofen, and the combination treatment...
  70. pmc N-substituted glutamyl sulfonamides as inhibitors of glutamate carboxypeptidase II (GCP2)
    Brian R Blank
    Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA 94132, USA
    Chem Biol Drug Des 77:241-7. 2011
    Glutamate carboxypeptidase II (GCP2) is a membrane-bound cell-surface peptidase which is implicated in several neurological disorders and is also over-expressed in prostate tumor cells...
  71. doi The localization of the Golgin GCC185 is independent of Rab6A/A' and Arl1
    Fiona J Houghton
    The Department of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Victoria 3010, Australia
    Cell 138:787-94. 2009
    ..The localization of two TGN golgins, p230/golgin-245 and golgin-97, is mediated by the small GTPase Arl1, whereas recruitment of the TGN golgin GCC185 is ..
  72. pmc Three members of the 6-cys protein family of Plasmodium play a role in gamete fertility
    Melissa R van Dijk
    Laboratory for Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
    PLoS Pathog 6:e1000853. 2010
    ..berghei. This analysis revealed that in addition to P48/45, two members (P230 and P47) also play an essential role in the process of parasite fertilization...
  73. pmc Stability of the small gamma-tubulin complex requires HCA66, a protein of the centrosome and the nucleolus
    Xavier Fant
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK
    J Cell Sci 122:1134-44. 2009
    ..Immunoblotting revealed reduced protein levels of all components of the gamma-tubulin small complex (gamma-tubulin, GCP2, and GCP3) in HCA66-depleted cells...
  74. pmc Crystal structure of γ-tubulin complex protein GCP4 provides insight into microtubule nucleation
    Valerie Guillet
    Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, Toulouse, France
    Nat Struct Mol Biol 18:915-9. 2011
    ..small complexes (γTuSCs) that comprise two molecules of γ-tubulin bound to γ-tubulin complex proteins (GCPs) GCP2 and GCP3...
  75. doi The role of chemokines in proangiogenic action induced by human adipose tissue-derived mesenchymal stem cells in the murine model of hindlimb ischemia
    Hyun Hwa Cho
    Department of Physiology, Pusan National University, Yangsan, Korea
    Cell Physiol Biochem 24:511-8. 2009
    ..In this study, we determined if human granulocyte chemotactic protein-2(GCP2) or monocyte chemoattractant protein-1(MCP1) is involved in the proangiogenic action of hASCs transplantation in ..
  76. pmc Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion
    Pei Ching Low
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia
    J Cell Biol 190:1053-65. 2010
    ..Kinase-active p110δ localizes to the Golgi complex in LPS-activated macrophages, and TNF is loaded into p230-labeled tubules, which cannot undergo fission when p110δ is inactivated...
  77. pmc A dispensable Plasmodium locus for stable transgene expression
    Vanessa Y Jacobs-Lorena
    Seattle Biomedical Research Institute, Seattle, WA 98109 5219, USA
    Mol Biochem Parasitol 171:40-4. 2010
    ..In P. berghei, the p230 paralog locus has been used for transgene expression. Here, we show that the P...
  78. doi Fusion of PDGFRB to two distinct loci at 3p21 and a third at 12q13 in imatinib-responsive myeloproliferative neoplasms
    Claire Hidalgo-Curtis
    University of Southampton, UK
    Br J Haematol 148:268-73. 2010
    ..We conclude that PDGFRB fuses to diverse partner genes in atypical myeloproliferative neoplasms (MPNs). Although very rare, identification of these fusions is critical for proper management of affected individuals...
  79. doi An Fgfr3-iCreER(T2) transgenic mouse line for studies of neural stem cells and astrocytes
    Kaylene M Young
    The Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, United Kingdom
    Glia 58:943-53. 2010
    ..of all major interneuron subtypes in the olfactory bulb (OB) from postnatal day 50 (P50) until at least P230 ( approximately 8 months of age)...
  80. doi Motility and protein phosphorylation in healthy and asthenozoospermic sperm
    Chying Chyuan Chan
    Graduate Institute of Medical Sciences, National Defence Medical Center, Taipei, Taiwan, ROC
    J Proteome Res 8:5382-6. 2009
    ..12 protein spots as having differential phosphorylation, including gamma-tubulin complex associated protein 2 (GCP2)...
  81. doi Altered GLUT4 trafficking in adipocytes in the absence of the GTPase Arfrp1
    Deike Hesse
    Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Biochem Biophys Res Commun 394:896-903. 2010
    ..Thus, Arfrp1 appears to be involved in sorting of GLUT4...
  82. doi A mutation in the Arabidopsis gamma-tubulin-containing complex causes helical growth and abnormal microtubule branching
    Masayoshi Nakamura
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630 0192, Japan
    J Cell Sci 122:2208-17. 2009
    ..We here show that a null mutation of Arabidopsis GCP2, a core subunit of the gamma-tubulin-containing complex, severely impaired the development of male and female ..
  83. doi A Golgi PKD activity reporter reveals a crucial role of PKD in nocodazole-induced Golgi dispersal
    Yannick F Fuchs
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    Traffic 10:858-67. 2009
    ..substrate sequence fused to enhanced green fluorescent protein (EGFP), specifically targeted to the TGN via the p230 GRIP domain...
  84. doi Frequency of BCR-ABL fusion transcripts in Iranian patients with chronic myeloid leukemia
    Marjan Yaghmaie
    Hematology Oncology and Bone Marrow Transplant Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Arch Iran Med 11:247-51. 2008
    ..Other less common fusion genes are b3a3 or b2a3 (p203) and e19a2 (p230). The incidence of one or other rearrangement in chronic myeloid leukemia patients varies in different reports...
  85. ncbi Molecular cloning of Drosophila TFIID subunits
    T Kokubo
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
    Nature 367:484-7. 1994
    ..Thus, TAFs are essential cofactors for regulated transcription. The complementary DNAs encoding the p230 (M(r) 230,000), p110 and p85 subunits of TFIID have recently been cloned...
  86. ncbi Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3
    Y Daigo
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan
    DNA Res 6:37-44. 1999
    ..The other gene F56 revealed no significant homology to any known genes. These results disclosed complete physical and transcriptional maps of the 1200-kb region of 3p present in YAC 936c1...
  87. pmc The fission yeast gamma-tubulin complex is required in G(1) phase and is a component of the spindle assembly checkpoint
    L Vardy
    Laboratory of Cell Regulation, Imperial Cancer Research Fund, PO Box 123, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    EMBO J 19:6098-111. 2000
    ..Spc97/Hs.Gcp2 and Sc. Spc98/Hs.Gcp3, respectively...
  88. ncbi Phosphatidyl inositol signaling by BCR/ABL: opportunities for drug development
    J D Griffin
    Leukemia Program, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Chemother Pharmacol 48:S11-6. 2001
    ..on chromosome 22, resulting in the production of one or more of a family of chimeric oncoproteins, p190, p210, or p230 BCR/ABL...
  89. pmc GCP5 and GCP6: two new members of the human gamma-tubulin complex
    S M Murphy
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Mol Biol Cell 12:3340-52. 2001
    ..Stoichiometry experiments revealed that there is a single copy of GCP5 and multiple copies of gamma-tubulin, GCP2, GCP3, and GCP4 within the gamma-tubulin complex...
  90. ncbi The gamma-tubulin complex protein Alp4 provides a link between the metaphase checkpoint and cytokinesis in fission yeast
    Leah Vardy
    Laboratory of Cell Regulation, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, PO Box 123, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Genes Cells 7:365-73. 2002
    ..The gamma-tubulin complex (gamma-TuC) localizes to the centrosome throughout the cell cycle and is directly involved in the organization of the mitotic spindle...
  91. ncbi BCR/ABL p210, p190 and p230 fusion genes in 250 Mexican patients with chronic myeloid leukaemia (CML)
    R M Arana-Trejo
    Genetica, Hospital General de Mexico, O D Facultad de Medicina, UNAM Mexico D F, Mexico
    Clin Lab Haematol 24:145-50. 2002
    ..Another, less common fusion gene is c3a2[e19a2], which encodes a p230 protein...
  92. ncbi Characterization of mouse tGolgin-1 (golgin-245/trans-golgi p230/256 kD golgin) and its upregulation during oligodendrocyte development
    David A Cowan
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6082, USA
    DNA Cell Biol 21:505-17. 2002
    ..we isolated a mouse cDNA that encodes tGolgin-1, a homolog of the human protein known as golgin-245, trans-golgi p230, or 256 kD golgin...
  93. ncbi BCR/ABL genes and leukemic phenotype: from molecular mechanisms to clinical correlations
    Fabrizio Pane
    CEINGE Biotechnologie Avanzate, and Dipartimento di Biochimica e Biotecnologie Mediche, Facolta di Medicina, Universita di Napoli Federico II, Italy
    Oncogene 21:8652-67. 2002
    ..depending on the length of the sequence of the BCR gene included, encode for the p190(BCR/ABL), P210(BCR/ABL), and P230(BCR/ABL) proteins. These three main variants are associated with distinct clinical types of human leukemias...
  94. ncbi Dual representation of pain in the operculo-insular cortex in humans
    Maud Frot
    Department of Functional Neurology and Epileptology, Hopital Neurologique, Lyon, France
    Brain 126:438-50. 2003
    ..and a deeper insular area, where responses with a similar pattern peaked 180-230 ms after the stimulus (N180-P230)...
  95. pmc Identification of an opd (organophosphate degradation) gene in an Agrobacterium isolate
    Irene Horne
    CSIRO Entomology, GPO Box 1700, Canberra, ACT 2601, Australia
    Appl Environ Microbiol 68:3371-6. 2002
    We isolated a bacterial strain, Agrobacterium radiobacter P230, which can hydrolyze a wide range of organophosphate (OP) insecticides. A gene encoding a protein involved in OP hydrolysis was cloned from A. radiobacter P230 and sequenced...
  96. ncbi Isolation and characterization of a 230 kDa protein (p230) specifically expressed in fetal brains: its involvement in neurite outgrowth from rat cerebral cortex neurons grown on monolayer of astrocytes
    S Wakatsuki
    Department of Biotechnology, The University of Tokyo
    J Biochem 122:1146-52. 1997
    ..against growth cone membrane fraction from fetal porcine brains, we have identified a 230 kDa antigen, termed p230. Western blot analysis of extracts from various tissues demonstrated that p230 is specifically expressed in brains, ..
  97. ncbi Apoptosis is induced in BHK cells by the tsBN462/13 mutation in the CCG1/TAFII250 subunit of the TFIID basal transcription factor
    T Sekiguchi
    Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Exp Cell Res 218:490-8. 1995
    ..golden hamsters, tsBN462 has a mutation in the gene encoding the largest subunit of the TFIID complex, TAFII250/p230/CCG1, and arrests in the G1 phase at the nonpermissive temperature, 39.5 degrees C...
  98. pmc The Drosophila 110-kDa transcription factor TFIID subunit directly interacts with the N-terminal region of the 230-kDa subunit
    T Kokubo
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 90:5896-900. 1993
    ..protein expressed in Sf9 cells via a baculovirus vector interacts directly with the 230-kDa subunit of TFIID (p230)...
  99. ncbi Drosophila 230-kD TFIID subunit, a functional homolog of the human cell cycle gene product, negatively regulates DNA binding of the TATA box-binding subunit of TFIID
    T Kokubo
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    Genes Dev 7:1033-46. 1993
    A Drosophila cDNA encoding the largest TFIID subunit (p230) was isolated using a degenerate oligodeoxynucleotide probe based on an amino acid sequence of the purified protein...
  100. ncbi Molecular characterization of Golgin-245, a novel Golgi complex protein containing a granin signature
    M J Fritzler
    Department of Medical Biochemistry, University of Calgary, Alberta, Canada
    J Biol Chem 270:31262-8. 1995
    ..This is the first report of a Golgi complex autoantigen that bears structural similarities to the granin family of proteins...
  101. ncbi p230 is associated with vesicles budding from the trans-Golgi network
    P A Gleeson
    Department of Pathology and Immunology, Monash University Medical School, Melbourne, Victoria, Australia
    J Cell Sci 109:2811-21. 1996
    ..We have previously described a brefeldin-A sensitive, hydrophilic protein (p230), containing a very high frequency of heptad repeats, found in the cytosol and associated with Golgi membranes...

Research Grants9

  1. Contribution of Pfs48/45 to Malaria Transmission-Blocking Immunity
    Kim C Williamson; Fiscal Year: 2013
    ..Pfs48/45 is one of four Plasmodium proteins (Pfs48/45 and P230, P25 and P28) that are the targets of monoclonal antibodies that effectively block malaria Tx and have been ..
  2. ROLE OF CHEMOKINES IN T CELL MEDIATED COLITIS
    James Lillard; Fiscal Year: 2002
    ..The second aim will assess the role of mIL-8Rh (murine IL- 8/GCP2 receptor), CCR5 (a RANTES receptor), CXCR3, and XCRl (Lptn receptor) interactions in the CD45RBHI CD4+ T cell ..
  3. ANTI-GAL IGG ON HUMAN RED CELLS: A MODEL FOR CELL AGING
    Uri Galili; Fiscal Year: 1993
    ..was found to result from diminished activity of the enzyme, alpha1>3 galactosyltransferase, which, in the Golg: apparatus, catalyzes the following reaction: Galbeta1>4GlcNAc-R + UDP- Gal>Gal alpha1>3Gal beta1>..
  4. BCR/ABL SIGNALING IN HUMAN LEUKEMIAS
    Ann Marie Pendergast; Fiscal Year: 2003
    ..P185 which is associated with a subset of acute lymphocytic leukemias (ALL), and P230 which is associated with chronic neutrophilic leukemia (CNL), a rare myeloproliferative disorder characterized by a ..
  5. APPLIED BISYSTEMS PRISM 3100 GENETIC ANALYZER
    Edward Chan; Fiscal Year: 2002
    ..This instrument will be an important asset to serve well in furthering the progress of many NIH- funded research in the MEM Department and the proposed RDCC. ..
  6. GOLGI COMPLEX ANTIBODIES AND AUTOANTIGENS
    Edward Chan; Fiscal Year: 2004
    ..It is anticipated that testing of the P.I.'s hypotheses will provide new insights into autoimmunity and autoimmune diseases associated with subcellular organelles. ..
  7. International Workshop on Autoantibodies & Autoimmunity
    Edward Chan; Fiscal Year: 2005
    ..abstract_text> ..
  8. GLUCOCORTICOID ATTENUATED RESPONSE GENES IN INFLAMMATION
    Jeffrey Smith; Fiscal Year: 2001
    ..Genes identified in this search are likely to encode pro-inflammatory mediators that participate in a wide range of inflammatory lung diseases in addition to endotoxemia. ..
  9. Regulation of Hematopoiesis by Notch Receptors
    James Griffin; Fiscal Year: 2007
    ..abstract_text> ..