p164 RhoGEF


Gene Symbol: p164 RhoGEF
Description: Rho guanine nucleotide exchange factor 17
Alias: P164RHOGEF, RHOGEF17, TEM4, p164-RhoGEF, rho guanine nucleotide exchange factor 17, 164 kDa Rho-specific guanine-nucleotide exchange factor, Rho guanine nucleotide exchange factor (GEF) 17, Rho-specific guanine-nucleotide exchange factor 164 kDa, tumor endothelial marker 4
Species: human
Products:     p164 RhoGEF

Top Publications

  1. Rümenapp U, Freichel Blomquist A, Wittinghofer B, Jakobs K, Wieland T. A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domain. Biochem J. 2002;366:721-8 pubmed
    ..Apparently, its N- and C-termini interact with each other, thereby inhibiting its GEF activity. ..
  2. Cervantes Villagrana R, Color Aparicio V, Reyes Cruz G, Vazquez Prado J. Protumoral bone marrow-derived cells migrate via Gβγ-dependent signaling pathways and exhibit a complex repertoire of RhoGEFs. J Cell Commun Signal. 2019;: pubmed publisher
  3. Wang S, Ma J, Zhang W, Shen J, Huang J, Peng J, et al. Typing tumors using pathways selected by somatic evolution. Nat Commun. 2018;9:4159 pubmed publisher
    ..This ESP framework substantially improves the definition of cancer pathways and subtypes from tumor genome data. ..
  4. Drake J, Strohbehn G, Bair T, Moreland J, Henry M. ZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cells. Mol Biol Cell. 2009;20:2207-17 pubmed publisher
    ..We isolated a subpopulation of cells, TEM4-18, that crossed an endothelial barrier more efficiently, but surprisingly, were less invasive than parental PC-3 ..
  5. Yang X, Li J, Fang Y, Zhang Z, Jin D, Chen X, et al. Rho Guanine Nucleotide Exchange Factor ARHGEF17 Is a Risk Gene for Intracranial Aneurysms. Circ Genom Precis Med. 2018;11:e002099 pubmed publisher
    ..Endothelial lesions were identified exclusively on cerebral blood vessels in the arhgef17-deficient zebrafish. Our results provide compelling evidence that ARHGEF17 is a risk gene for IA. ..
  6. Hernández García R, Iruela Arispe M, Reyes Cruz G, Vázquez Prado J. Endothelial RhoGEFs: A systematic analysis of their expression profiles in VEGF-stimulated and tumor endothelial cells. Vascul Pharmacol. 2015;74:60-72 pubmed publisher
    ..In summary, our results provide a detailed assessment of RhoGEFs expression profiles in the endothelium and set the basis to systematically address their regulation in vascular signaling. ..
  7. Marquardt J, Fisk H. ARHGEF17 sets the timer for retention of Mps1 at kinetochores. J Cell Biol. 2016;212:615-6 pubmed publisher
    ..2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201408089) show that interaction with and phosphorylation of its substrate, ARHGEF17, regulates Mps1 kinetochore retention, suggesting an autoregulated, timer-like mechanism. ..
  8. Mitin N, Rossman K, Der C. Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4. PLoS ONE. 2012;7:e41876 pubmed publisher
    ..In this study, we provide the first characterization of the full-length protein encoded by RhoGEF TEM4 and delineate its domain structure, catalytic activity, and subcellular localization...
  9. Lutz S, Mohl M, Rauch J, Weber P, Wieland T. RhoGEF17, a Rho-specific guanine nucleotide exchange factor activated by phosphorylation via cyclic GMP-dependent kinase I?. Cell Signal. 2013;25:630-8 pubmed publisher
    b>RhoGEF17, the product of the ARHGEF17 gene, is a Rho-specific guanine nucleotide exchange factor (GEF) with an unusual structure and so far unknown function...

More Information


  1. Carson Walter E, Watkins D, Nanda A, Vogelstein B, Kinzler K, St Croix B. Cell surface tumor endothelial markers are conserved in mice and humans. Cancer Res. 2001;61:6649-55 pubmed
    ..The coordinate expression of TEM1, TEM5, and TEM8 on tumor endothelium in humans and mice makes these genes attractive targets for the development of antiangiogenic therapies. ..
  2. Bloethner S, Mould A, Stark M, Hayward N. Identification of ARHGEF17, DENND2D, FGFR3, and RB1 mutations in melanoma by inhibition of nonsense-mediated mRNA decay. Genes Chromosomes Cancer. 2008;47:1076-85 pubmed publisher
    ..We conclude that although the false positive rate is high, most likely due to the lack of DNA mismatch repair gene defects, the GINI protocol is one approach to discover novel TSGs in melanoma. ..
  3. Mitin N, Rossman K, Currin R, Anne S, Marshall T, Bear J, et al. The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility. PLoS ONE. 2013;8:e66260 pubmed publisher
    ..Here, we examined the role of the RhoGEF TEM4, an activator of Rho family GTPases, in regulating cellular migration of endothelial cells...
  4. Isokane M, Walter T, Mahen R, Nijmeijer B, Hériché J, Miura K, et al. ARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochores. J Cell Biol. 2016;212:647-59 pubmed publisher
    ..This mitosis-specific role is independent of ARHGEF17's RhoGEF activity in interphase. Our study thus assigns a new mitotic function to ARHGEF17 and reveals the molecular mechanism for a key step in SAC establishment. ..