p130Cas

Summary

Gene Symbol: p130Cas
Description: BCAR1, Cas family scaffold protein
Alias: CAS, CAS1, CASS1, CRKAS, P130Cas, breast cancer anti-estrogen resistance protein 1, BCAR1, Cas family scaffolding protein, Cas scaffolding protein family member 1, Crk-associated substrate p130Cas
Species: human
Products:     p130Cas

Top Publications

  1. Wisniewska M, Bossenmaier B, Georges G, Hesse F, Dangl M, Künkele K, et al. The 1.1 A resolution crystal structure of the p130cas SH3 domain and ramifications for ligand selectivity. J Mol Biol. 2005;347:1005-14 pubmed
    The Crk-associated tyrosine kinase substrate p130cas (CAS) is a docking protein containing an SH3 domain near its N terminus, followed by a short proline-rich segment, a large central substrate domain composed of 15 repeats of the four ..
  2. Dorssers L, Grebenchtchikov N, Brinkman A, Look M, van Broekhoven S, de Jong D, et al. The prognostic value of BCAR1 in patients with primary breast cancer. Clin Cancer Res. 2004;10:6194-202 pubmed
    BCAR1, the human homologue of the rat p130Cas protein, was identified in a functional screen for human breast cancer cell proliferation resistant to antiestrogen drugs...
  3. Manie S, Beck A, Astier A, Law S, Canty T, Hirai H, et al. Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells. J Biol Chem. 1997;272:4230-6 pubmed
    The Crk-associated substrate p130(Cas) (Cas) and the recently described human enhancer of filamentation 1 (HEF1) are two proteins with similar structure (64% amino acid homology), which are thought to act as "docking" molecules ..
  4. Sakakibara A, Hattori S. Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways. J Biol Chem. 2000;275:6404-10 pubmed
    b>Cas (Crk-associated substrate) and HEF1 (human enhancer of filamentation) are related adaptor proteins that function in integrin-mediated cell adhesion and antigen receptor signaling pathways...
  5. Mayer B, Hirai H, Sakai R. Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases. Curr Biol. 1995;5:296-305 pubmed
    ..and mutant Abl kinases to examine the roles of the Abl's SH2 and catalytic domains in phosphorylation of p130CAS, a model substrate that has multiple potential phosphorylation sites...
  6. Hempel N, Bartling T, Mian B, Melendez J. Acquisition of the metastatic phenotype is accompanied by H2O2-dependent activation of the p130Cas signaling complex. Mol Cancer Res. 2013;11:303-12 pubmed publisher
    ..Here, we define the signaling adaptor protein p130Cas (Crk-associated substrate) as a key redox-responsive molecular trigger that is engaged in highly invasive ..
  7. Schuh N, Guerrero M, Schrecengost R, Bouton A. BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling. J Biol Chem. 2010;285:2309-17 pubmed publisher
    ..One such protein, p130(Cas) (Cas), is expressed at high levels in both breast cancer cell lines and breast tumors, providing a potential ..
  8. Takino T, Tamura M, Miyamori H, Araki M, Matsumoto K, Sato H, et al. Tyrosine phosphorylation of the CrkII adaptor protein modulates cell migration. J Cell Sci. 2003;116:3145-55 pubmed
    ..of CrkII inhibited dephosphorylation of focal adhesion components such as p130 Crk-associated substrate (p130cas) and paxillin by protein tyrosine phosphatase 1B (PTP1B)...
  9. Cho S, Klemke R. Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold. J Cell Biol. 2002;156:725-36 pubmed
    ..Pseudopodia growth requires assembly of a p130Crk-associated substrate (CAS)/c-CrkII (Crk) scaffold, which facilitates translocation and activation of Rac1...

More Information

Publications76

  1. Yi J, Kloeker S, Jensen C, Bockholt S, Honda H, Hirai H, et al. Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers. J Biol Chem. 2002;277:9580-9 pubmed
    ..This assay revealed that both TRIP6 and zyxin interact with CasL/HEF1, a member of the Cas family...
  2. Bouton A, Riggins R, Bruce Staskal P. Functions of the adapter protein Cas: signal convergence and the determination of cellular responses. Oncogene. 2001;20:6448-58 pubmed
    Since Cas was first identified as a highly phosphorylated 130 kilodalton protein that associated with the v-Src and v-Crk-oncoproteins, considerable effort has been made to determine its function...
  3. Li E, Stupack D, Brown S, Klemke R, Schlaepfer D, Nemerow G. Association of p130CAS with phosphatidylinositol-3-OH kinase mediates adenovirus cell entry. J Biol Chem. 2000;275:14729-35 pubmed
    The Crk-associated substrate, p130(CAS), has been implicated in the regulation of the actin cytoskeleton following ligation of cell integrins with the extracellular matrix...
  4. Kirsch K, Georgescu M, Ishimaru S, Hanafusa H. CMS: an adapter molecule involved in cytoskeletal rearrangements. Proc Natl Acad Sci U S A. 1999;96:6211-6 pubmed
    b>Cas ligand with multiple Src homology (SH) 3 domains (CMS) is an ubiquitously expressed signal transduction molecule that interacts with the focal adhesion protein p130(Cas)...
  5. Kirsch K, Georgescu M, Hanafusa H. Direct binding of p130(Cas) to the guanine nucleotide exchange factor C3G. J Biol Chem. 1998;273:25673-9 pubmed
    p130(Cas) (Cas; crk-associated substrate) belongs to a new family of docking molecules. It contains one Src homology (SH) 3 domain in its amino-terminal region followed by a region containing binding motifs for SH2 and SH3 domains...
  6. Klemke R, Leng J, Molander R, Brooks P, Vuori K, Cheresh D. CAS/Crk coupling serves as a "molecular switch" for induction of cell migration. J Cell Biol. 1998;140:961-72 pubmed
    ..Associated with this induction of migration was the anchorage-dependent phosphorylation of p130CAS (Crk-associated substrate), leading to its coupling to the adaptor protein c-CrkII (Crk)...
  7. Liu F, Sells M, Chernoff J. Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand. Mol Cell Biol. 1998;18:250-9 pubmed
    We have recently shown that protein tyrosine phosphatase 1B (PTP1B) associates with the docking protein p130Cas in 3Y1 rat fibroblasts. This interaction is mediated by a proline-rich sequence on PTP1B and the SH3 domain on p130Cas...
  8. Garton A, Flint A, Tonks N. Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST. Mol Cell Biol. 1996;16:6408-18 pubmed
    ..proteins associated in stable complexes exclusively with the same 130-kDa protein, which was identified as p130(cas) by immunoblotting...
  9. Liu F, Hill D, Chernoff J. Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas). J Biol Chem. 1996;271:31290-5 pubmed
    ..In this study, we establish that PTP1B interacts with Crk, Grb2, and p130(Cas) in vitro and with at least one of these, p130(Cas), in intact cells...
  10. Schlaepfer D, Hunter T. Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src. J Biol Chem. 1997;272:13189-95 pubmed
    ..Expression of wild type and Phe-925 FAK, but not Phe-397 FAK, enhanced p130(Cas) association with FAK, Shc tyrosine phosphorylation, and Grb2 binding to Shc after FN stimulation...
  11. Vuori K, Hirai H, Aizawa S, Ruoslahti E. Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases. Mol Cell Biol. 1996;16:2606-13 pubmed
    ..Among these are the focal adhesion proteins p130cas (Cas) and focal adhesion kinase (FAK)...
  12. Cai D, Felekkis K, Near R, O Neill G, van Seventer J, Golemis E, et al. The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42. J Immunol. 2003;170:969-78 pubmed
    ..B cell AND-34 associates with both the docking molecules p130Cas and HEF1...
  13. Wei L, Yang Y, Zhang X, Yu Q. Anchorage-independent phosphorylation of p130(Cas) protects lung adenocarcinoma cells from anoikis. J Cell Biochem. 2002;87:439-49 pubmed
    The regulation and function of the signaling adaptor protein p130(Cas) in tumor cell anchorage-independent survival, or anoikis resistance, were investigated in human lung adenocarcinoma cells...
  14. Kirsch K, Kensinger M, Hanafusa H, August A. A p130Cas tyrosine phosphorylated substrate domain decoy disrupts v-crk signaling. BMC Cell Biol. 2002;3:18 pubmed
    The adaptor protein p130Cas (Cas) has been shown to be involved in different cellular processes including cell adhesion, migration and transformation...
  15. Salgia R, Pisick E, Sattler M, Li J, Uemura N, Wong W, et al. p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene. J Biol Chem. 1996;271:25198-203 pubmed
    ..Here we demonstrate that another cellular protein linked to BCR/ABL through the CRKL-SH2 domain is p130(CAS)...
  16. Cho S, Klemke R. Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix. J Cell Biol. 2000;149:223-36 pubmed
    ..kinase (ERK) activation and molecular coupling of the adaptor proteins p130 Crk-associated substrate (CAS) and c-CrkII (Crk) represent two distinct pathways that induce cell invasion and protect cells from apoptosis in a ..
  17. Donaldson J, Dempsey P, Reddy S, Bouton A, Coffey R, Hanks S. Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells. Exp Cell Res. 2000;256:168-78 pubmed
    Crk-associated substrate (p130(Cas), Cas) is a docking protein first recognized as having elevated phosphotyrosine content in mammalian cells transformed by v-Src and v-Crk oncoproteins...
  18. Tamura M, Gu J, Takino T, Yamada K. Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas. Cancer Res. 1999;59:442-9 pubmed
    ..PTEN on cell invasion, migration, and growth as well as the involvement of FAK and p130 Crk-associated substrate (p130Cas) were investigated in U87MG glioblastoma cells missing PTEN...
  19. van der Flier S, Brinkman A, Look M, Kok E, Meijer van Gelder M, Klijn J, et al. Bcar1/p130Cas protein and primary breast cancer: prognosis and response to tamoxifen treatment. J Natl Cancer Inst. 2000;92:120-7 pubmed
    The product of the Bcar1/p130Cas (breast cancer resistance/p130Crk-associated substrate) gene causes resistance to antiestrogen drugs in human breast cancer cells in vitro...
  20. Evans I, Yamaji M, Britton G, Pellet Many C, Lockie C, Zachary I, et al. Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells. Mol Cell Biol. 2011;31:1174-85 pubmed publisher
    ..However, the NRP1 signaling pathways important for cell motility are poorly understood. Here we report that p130(Cas) tyrosine phosphorylation is stimulated by hepatocyte growth factor and platelet-derived growth factor in U87MG ..
  21. Sakai R, Iwamatsu A, Hirano N, Ogawa S, Tanaka T, Mano H, et al. A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J. 1994;13:3748-56 pubmed
    ..substrate) is a common cellular target of phosphorylation signal via v-Crk and v-Src oncoproteins, and its unique structure indicates the possible role of p130Cas in assembling signals from multiple SH2-containing molecules.
  22. Tachibana K, Urano T, Fujita H, Ohashi Y, Kamiguchi K, Iwata S, et al. Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates. J Biol Chem. 1997;272:29083-90 pubmed
    ..phosphorylation of various proteins including focal adhesion kinase (pp125(FAK)) and Crk-associated substrate (Cas)...
  23. Sawada Y, Tamada M, Dubin Thaler B, Cherniavskaya O, Sakai R, Tanaka S, et al. Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Cell. 2006;127:1015-26 pubmed
    ..Previously, we showed that tyrosine phosphorylation of p130Cas (Cas) in a cytoskeletal complex is involved in force-dependent activation of the small GTPase Rap1...
  24. Angers Loustau A, Cote J, Charest A, Dowbenko D, Spencer S, Lasky L, et al. Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts. J Cell Biol. 1999;144:1019-31 pubmed
    ..This phenomenon appears to be due in part to a constitutive increase in tyrosine phosphorylation of p130(CAS), a known PTP-PEST substrate, paxillin, which associates with PTP-PEST in vitro, and focal adhesion kinase (FAK)...
  25. Tornillo G, Bisaro B, Camacho Leal M, Galiè M, Provero P, Di Stefano P, et al. p130Cas promotes invasiveness of three-dimensional ErbB2-transformed mammary acinar structures by enhanced activation of mTOR/p70S6K and Rac1. Eur J Cell Biol. 2011;90:237-48 pubmed publisher
    ..We have previously demonstrated that p130Cas adaptor is a crucial mediator of ErbB2 transformation...
  26. Brinkman A, van der Flier S, Kok E, Dorssers L. BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells. J Natl Cancer Inst. 2000;92:112-20 pubmed
    ..Sequence analysis of human BCAR1 cDNA predicted a protein of 870 amino acids that was strongly homologous to rat p130Cas-adapter protein. Genomic analysis revealed that BCAR1 consists of seven exons and is located at chromosome 16q23...
  27. Garton A, Burnham M, Bouton A, Tonks N. Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition. Oncogene. 1997;15:877-85 pubmed
    The protein tyrosine phosphatase PTP-PEST displays remarkable substrate specificity, in vitro and in vivo for p130cas a signalling intermediate implicated in mitogenic signalling, cell-adhesion induced signalling, and in transformation ..
  28. Girardin S, Yaniv M. A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation. EMBO J. 2001;20:3437-46 pubmed
    ..Furthermore, CrkII recruits JNK1 to a p130Cas multiprotein complex where it may be activated through a hematopoietic progenitor kinase 1- and mitogen-activated ..
  29. Law S, Estojak J, Wang B, Mysliwiec T, Kruh G, Golemis E. Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae. Mol Cell Biol. 1996;16:3327-37 pubmed
    ..In contrast to p130cas, the expression of HEF1 appears to be tissue specific...
  30. Cabodi S, Moro L, Baj G, Smeriglio M, Di Stefano P, Gippone S, et al. p130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells. J Cell Sci. 2004;117:1603-11 pubmed
    ..A major substrate of c-Src kinase activity is the cytoskeletal protein p130Cas, originally identified in v-Src-transformed cells...
  31. Guo C, Liu Q, Yang W, Zhang Z, Yao Y. Relation among p130Cas, E-cadherin and beta-catenin expression, clinicopathologic significance and prognosis in human hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int. 2008;7:490-6 pubmed
    b>p130Cas (p130Crk-associated substance) is a junction protein that is important to the adhesion between cytoskeleton and extracellular matrix...
  32. Wendt M, Smith J, Schiemann W. p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity. J Biol Chem. 2009;284:34145-56 pubmed publisher
    ..that these changes in TGF-beta signaling are concomitant with aberrant expression of the focal adhesion protein, p130Cas. Indeed, elevating expression of either the full-length (FL) or just the carboxyl terminus (CT) of p130Cas in ..
  33. Schrecengost R, Riggins R, Thomas K, Guerrero M, Bouton A. Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane ruffling. Cancer Res. 2007;67:6174-82 pubmed
    ..BCAR3 was highly expressed in multiple breast cancer cell lines, where it associated with another protein, p130(Cas) (also known as breast cancer antiestrogen resistance-1; BCAR1), that plays a role in both tamoxifen resistance and ..
  34. Polte T, Hanks S. Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas. Proc Natl Acad Sci U S A. 1995;92:10678-82 pubmed
    ..interact with FAK via their Src homology 3 (SH3) domains: a v-Crk-associated tyrosine kinase substrate (Cas), p130Cas, and a still uncharacterized protein, FIPSH3-2, which contains an SH3 domain closely related to that of p130Cas...
  35. Kim W, Seok Kang Y, Soo Kim J, Shin N, Hanks S, Song W. The integrin-coupled signaling adaptor p130Cas suppresses Smad3 function in transforming growth factor-beta signaling. Mol Biol Cell. 2008;19:2135-46 pubmed publisher
    ..signaling counteracts the inhibitory effects of TGF-beta on cell growth and that this effect is mediated by p130Cas (Crk-associated substrate, 130 kDa)...
  36. Cary L, Han D, Polte T, Hanks S, Guan J. Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration. J Cell Biol. 1998;140:211-21 pubmed
    ..In this report, we have examined the role of FAK association with Grb2 and p130(Cas), two downstream events of the FAK/Src complex that could mediate integrin-stimulated activation of extracellular ..
  37. Defilippi P, Di Stefano P, Cabodi S. p130Cas: a versatile scaffold in signaling networks. Trends Cell Biol. 2006;16:257-63 pubmed
    ..The involvement of p130Cas in cell motility as a component of the integrin signaling machinery is well established...
  38. Lu Y, Brush J, Stewart T. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway. J Biol Chem. 1999;274:10047-52 pubmed
    ..or insulin leads to NSP1 phosphorylation and increased association with a hypophosphorylated adaptor protein, p130(Cas)...
  39. Cote J, Charest A, Wagner J, Tremblay M. Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases using PTP-PEST as a model. Biochemistry. 1998;37:13128-37 pubmed
    ..The p130 was identified as p130(Cas), and direct immunoprecipitates of p130(Cas) demonstrate that this protein is constitutively hyperphosphorylated in ..
  40. O Neill G, Fashena S, Golemis E. Integrin signalling: a new Cas(t) of characters enters the stage. Trends Cell Biol. 2000;10:111-9 pubmed
    ..The Cas proteins (p130Cas, HEF1/Cas-L and Efs/Sin), a family of docking proteins containing multiple interaction domains, are important ..
  41. Delogu G, Matos M, Fanti M, Era B, Medda R, Pieroni E, et al. 2-Phenylbenzofuran derivatives as butyrylcholinesterase inhibitors: Synthesis, biological activity and molecular modeling. Bioorg Med Chem Lett. 2016;26:2308-13 pubmed publisher
    ..Moreover, molecular dynamics simulations revealed that compound 16 binds to both the catalytic anionic site (CAS) and peripheral anionic site (PAS) of BChE and it displayed the best interaction energy value, in agreement with ..
  42. Shipman S, Nivala J, Macklis J, Church G. CRISPR-Cas encoding of a digital movie into the genomes of a population of living bacteria. Nature. 2017;547:345-349 pubmed publisher
    ..Using the Cas1-Cas2 integrase, the CRISPR-Cas microbial immune system stores the nucleotide content of invading viruses to confer ..
  43. Ding J, Zhang Y, Zhong H, Ao C, Li J, Han J. An all-atom molecular dynamics study of the anti-interferon signaling of Ebola virus: interaction mechanisms of EBOV VP24 binding to Karyopherin alpha5. Mol Biosyst. 2017;13:1031-1045 pubmed publisher
    ..Meanwhile, by combining the decomposition of binding free energies (DC) with computational alanine scanning (CAS) results, it is shown that VP24 residues R137 and T138 will be potential targets for EBOV VP24 inhibitors, and ..
  44. Pálmai M, Pethő A, Nagy L, Klébert S, May Z, Mihaly J, et al. Direct immobilization of manganese chelates on silica nanospheres for MRI applications. J Colloid Interface Sci. 2017;498:298-305 pubmed publisher
    The development of tissue specific magnetic resonance imaging (MRI) contrast agents (CAs) is very desirable to achieve high contrast ratio combined with excellent anatomical details...
  45. Watanabe J, Ogata T, Higashi T, Inoue T. Cognitive Change 1 Year after CEA or CAS Compared with Medication. J Stroke Cerebrovasc Dis. 2017;26:1297-1305 pubmed publisher
    ..aimed to investigate cognitive changes between before carotid endarterectomy (CEA) or carotid artery stenting (CAS) and 1 year after intervention using cognitive evaluation tools...
  46. Obeid T, Alshaikh H, Nejim B, Arhuidese I, Locham S, Malas M. Fixed and variable cost of carotid endarterectomy and stenting in the United States: A comparative study. J Vasc Surg. 2017;65:1398-1406.e1 pubmed publisher
    Despite multiple landmark clinical trials, little data exists on real-world cost of carotid artery stenting (CAS) and carotid endarterectomy (CEA) to the United States healthcare system...
  47. Yu C, Han X, Zhang X, Yu B, Dong Q. Long-term effects of white matter changes on the risk of stroke recurrence after carotid artery stenting in patients with symptomatic carotid artery stenosis. J Neurol Sci. 2016;369:11-14 pubmed publisher
    ..are associated with increased 30-day perioperative risk of stroke in patients undergoing carotid artery stenting (CAS). However, there is no data showing their impact on postoperative long-term stroke recurrence or survival...
  48. Tsukahara T. Surgical Treatment of Carotid Artery Stenosis. Acta Neurochir Suppl. 2016;123:109-14 pubmed publisher
    The indications for carotid endarterectomy (CEA) and carotid artery stenting (CAS) have not been established...
  49. Zhu D, Yang X, He Y, Zhou W, Song X, Wang J, et al. Comparative genomic analysis identifies structural features of CRISPR-Cas systems in Riemerella anatipestifer. BMC Genomics. 2016;17:689 pubmed publisher
    ..Only three cas genes (cas1, cas2 and cas9) were located upstream of CRISPR1...
  50. Akdemir A, Güzel Akdemir Ã, Karalı N, Supuran C. Isatin analogs as novel inhibitors of Candida spp. β-carbonic anhydrase enzymes. Bioorg Med Chem. 2016;24:1648-52 pubmed publisher
    ..inhibition data of structurally novel isatin-containing sulfonamides were determined for two carbonic anhydrases (CAs, EC 4.2.1.1) from pathogenic Candida species (CaNce103 from C. albicans and CgNce103 from C. glabrata)...
  51. Zhao X, Xu M, Wei R, Liu Y. Expression of OsCAS (Calcium-Sensing Receptor) in an Arabidopsis Mutant Increases Drought Tolerance. PLoS ONE. 2015;10:e0131272 pubmed publisher
    The calcium-sensing receptor (CaS), which is localized in the chloroplasts, is a crucial regulator of extracellular calcium-induced stomatal closure in Arabidopsis. It has homologs in Oryza sativa and other plants...
  52. Larsson H, Klint P, Landgren E, Claesson Welsh L. Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk. J Biol Chem. 1999;274:25726-34 pubmed
    ..Crk SH2 and SH3 domains formed ligand-independent complexes with Shc, C3G, and the Crk-associated substrate (Cas). Tyrosine phosphorylation of C3G and Cas increased as a consequence of growth factor treatment...
  53. Dunnick J, Merrick B, Brix A, Morgan D, Gerrish K, Wang Y, et al. Molecular Changes in the Nasal Cavity after N, N-dimethyl-p-toluidine Exposure. Toxicol Pathol. 2016;44:835-47 pubmed publisher
    N, N-dimethyl-p-toluidine (DMPT; Cas No...
  54. Good E, Länne T, Wilhelm E, Perk J, Jaarsma T, De Muinck E. High-grade carotid artery stenosis: A forgotten area in cardiovascular risk management. Eur J Prev Cardiol. 2016;23:1453-60 pubmed publisher
    Patients with high-grade (≥70%) carotid artery stenosis (CAS) rank in the highest risk category for future cardiovascular (CV) events, but the quality of cardiovascular risk management in this patient group is unknown...
  55. Kumar B, Chandran B. KSHV Entry and Trafficking in Target Cells-Hijacking of Cell Signal Pathways, Actin and Membrane Dynamics. Viruses. 2016;8: pubmed
    ..which results in the simultaneous induction of FAK, Src, PI3-K, Rho-GTPase, ROS, Dia-2, PKC ?, c-Cbl, CIB1, Crk, p130Cas and GEF-C3G signal and adaptor molecules that play critical roles in the modulation of membrane and actin ..
  56. van Erp P, Patterson A, Kant R, Berry L, Golden S, Forsman B, et al. Conformational Dynamics of DNA Binding and Cas3 Recruitment by the CRISPR RNA-guide Cascade Complex. ACS Chem Biol. 2017;: pubmed publisher
    ..In Escherichia coli, short CRISPR-derived RNAs (crRNAs) assemble with Cas (CRISPR-associated) proteins into a 405-kilodalton multi-subunit surveillance complex called Cascade (CRISPR-..
  57. Weng L, Wang X, Yu Q. Transmembrane tyrosine phosphatase LAR induces apoptosis by dephosphorylating and destabilizing p130Cas. Genes Cells. 1999;4:185-96 pubmed
    ..The over-expression of LAR in tissue culture cells specifically decreased the steady state protein level of p130Cas, a multifunctional signal assembly protein in signal transduction, by reducing the tyrosine phosphorylation and ..
  58. Ishida Y, Otsuka A, Kabashima K. Cutaneous angiosarcoma: update on biology and latest treatment. Curr Opin Oncol. 2017;: pubmed publisher
    The present review aims to provide readers with the latest updates on the biology and clinical management of cutaneous angiosarcoma (cAS).
  59. Zhou B, Liu L, Reddivari M, Zhang X. The palmitoylation of metastasis suppressor KAI1/CD82 is important for its motility- and invasiveness-inhibitory activity. Cancer Res. 2004;64:7455-63 pubmed
    ..reversal of cell motility seen in the palmitoylation-deficient KAI1/CD82 mutant correlates with regaining of p130(CAS)-CrkII coupling, a signaling step important for KAI1/CD82's activity...
  60. Repizo G, Viale A, Borges V, Cameranesi M, Taib N, Espariz M, et al. The Environmental Acinetobacter baumannii Isolate DSM30011 Reveals Clues into the Preantibiotic Era Genome Diversity, Virulence Potential, and Niche Range of a Predominant Nosocomial Pathogen. Genome Biol Evol. 2017;9:2292-2307 pubmed publisher
    ..phage-related genes, five containing toxin genes of the type-6 secretion system, and one with an atypical CRISPRs/cas cluster...
  61. Tummala S, Schiphof D, Byrjalsen I, Dam E. Gender Differences in Knee Joint Congruity Quantified from MRI: A Validation Study with Data from Center for Clinical and Basic Research and Osteoarthritis Initiative. Cartilage. 2018;9:38-45 pubmed publisher
    ..Results Female CAs were significantly higher than male CAs after normalization, male CIs were significantly higher than female CIs ..
  62. Abe N, Iki N. Multi-coloration of Calixarene-coated Silver Nanoparticles for the Visual Discrimination of Metal Elements. Anal Sci. 2017;33:1141-1145 pubmed publisher
    ..0, solutions of silver nanoparticles (AgNPs) coated with calix[4]arene-p-tetrasulfonate (CAS-AgNP) exhibited multi-coloration from yellow to orange, violet, and green, depending on the metal elements present, ..
  63. Zalatan J. CRISPR-Cas RNA Scaffolds for Transcriptional Programming in Yeast. Methods Mol Biol. 2017;1632:341-357 pubmed publisher
    ..This protocol describes how to construct multi-scRNA transcriptional programs in yeast, including target site selection, cloning strategies, and yeast engineering. ..
  64. Taciak M, Barszcz M, Swiech E, Tuśnio A, Bachanek I. Interactive effects of protein and carbohydrates on production of microbial metabolites in the large intestine of growing pigs. Arch Anim Nutr. 2017;71:192-209 pubmed publisher
    ..36 pigs (15 kg initial body weight) divided into six groups, fed cereal-based diets with highly digestible casein (CAS) or potato protein concentrate (PPC) of lower ileal digestibility...
  65. Bisaro B, Montani M, Konstantinidou G, Marchini C, Pietrella L, Iezzi M, et al. p130Cas/Cyclooxygenase-2 axis in the control of mesenchymal plasticity of breast cancer cells. Breast Cancer Res. 2012;14:R137 pubmed publisher
    ..The p130Cas scaffold protein is overexpressed in human ER+ and HER2+ breast cancer where it contributes to cancer progression,..
  66. Tang D. p130 Crk-associated substrate (CAS) in vascular smooth muscle. J Cardiovasc Pharmacol Ther. 2009;14:89-98 pubmed publisher
    ..Crk-associated substrate (CAS), the first discovered member of the adapter protein CAS family, has recently emerged as a critical cellular ..
  67. Dorssers L, van Agthoven T, Dekker A, van Agthoven T, Kok E. Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bcar-1, a common integration site. Mol Endocrinol. 1993;7:870-8 pubmed
    ..In addition, we have shown that in vitro insertional mutagenesis using defective retroviruses can be applied for gene tagging in human cells. ..