p130

Summary

Gene Symbol: p130
Description: RB transcriptional corepressor like 2
Alias: P130, Rb2, retinoblastoma-like protein 2, 130 kDa retinoblastoma-associated protein, PRB2, RBR-2, retinoblastoma-like 2, retinoblastoma-related protein 2
Species: human
Products:     p130

Top Publications

  1. Burchacka E, Łukaszewicz M, Kułażyński M. Determination of mechanisms of action of active carbons as a feed additive. Bioorg Chem. 2019;: pubmed publisher
    ..Our results also indicate that the examined active carbons from beech (KB), coconut shells (TE50), and hard coal (RB2) do not adsorb (or adsorb with very limited efficiency) the vitamins that are routinely added to feed, such as A, ..
  2. Basuroy S, DUNAGAN M, Sheth P, Seth A, Rao R. Hydrogen peroxide activates focal adhesion kinase and c-Src by a phosphatidylinositol 3 kinase-dependent mechanism and promotes cell migration in Caco-2 cell monolayers. Am J Physiol Gastrointest Liver Physiol. 2010;299:G186-95 pubmed publisher
    ..c-Src and FAK was associated with a rapid increase in the tyrosine phosphorylation and the levels of paxillin and p130(CAS) in actin-rich, detergent-insoluble fractions...
  3. Tanaka S, Suzuki K, Sakaguchi M. The prolyl oligopeptidase inhibitor SUAM-14746 attenuates the proliferation of human breast cancer cell lines in vitro. Breast Cancer. 2017;24:658-666 pubmed publisher
    ..Moreover, the SUAM-14746-mediated cell cycle arrest of MCF7 cells was associated with increased pRb2/p130 protein expression and an increase in the number of cells in the quiescent G0 state, as defined by low ..
  4. Shizu R, Abe T, Benoki S, Takahashi M, Kodama S, Miayata M, et al. PXR stimulates growth factor-mediated hepatocyte proliferation by cross-talk with the FOXO transcription factor. Biochem J. 2016;473:257-66 pubmed publisher
    ..The results of the present study suggest that PXR activation stimulates growth factor-mediated hepatocyte proliferation in mice, at least in part, through inhibiting FOXO3 from accelerating cell-cycle progression. ..
  5. Sancho V, Nuche Berenguer B, Jensen R. The Src kinase Yes is activated in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters, but not pancreatic growth factors, which stimulate its association with numerous other signaling molecules. Biochim Biophys Acta. 2012;1823:1285-94 pubmed publisher
    ..Moreover, CCK/TPA stimulated Yes interacted with a number of other signaling proteins, including Shc, PKD, p130(Cas), PI3K and PTEN...
  6. Nishida S, Yoshizaki H, Yasui Y, Kuwahara T, Kiyokawa E, Kohno M. Collagen VI suppresses fibronectin-induced enteric neural crest cell migration by downregulation of focal adhesion proteins. Biochem Biophys Res Commun. 2018;495:1461-1467 pubmed publisher
    ..Additionally, in ENCCs cultured on plates containing ColVI, the expression and phosphorylation of p130Cas, a members of focal adhesion complexes, was reduced...
  7. Thakre A, Zore G, Kodgire S, Kazi R, Mulange S, Patil R, et al. Limonene inhibits Candida albicans growth by inducing apoptosis. Med Mycol. 2018;56:565-578 pubmed publisher
    ..albicans growth by cell wall/membrane damage induced oxidative stress that leads to DNA damage resulting into modulation of cell cycle and induction of apoptosis through nucleolar stress and metacaspase dependent pathway. ..
  8. Wang Y, Liang X, Chen Y, Zhao X. Screening SIRT1 Activators from Medicinal Plants as Bioactive Compounds against Oxidative Damage in Mitochondrial Function. Oxid Med Cell Longev. 2016;2016:4206392 pubmed publisher
    ..Among those active compounds, four compounds, ginsenoside Rb2, ginsenoside F1, ginsenoside Rc, and schisandrin A, were further studied to validate the SIRT1-activation effects ..
  9. Namkung J, Song J, Jo H, Kim M, Lew Y, Donahoe P, et al. Mullerian inhibiting substance induces apoptosis of human endometrial stromal cells in endometriosis. J Clin Endocrinol Metab. 2012;97:3224-30 pubmed publisher
    ..In the ESCs, which contain defective p16, MIS increased the expression of pocket proteins p107 and p130 and decreased E2F transcription factor 1. The results support a central role for MIS in endometriosis...

More Information

Publications150 found, 100 shown here

  1. Su S, Chen X, Geng J, Minges J, Grossman G, Wilson E. Melanoma antigen-A11 regulates substrate-specificity of Skp2-mediated protein degradation. Mol Cell Endocrinol. 2017;439:1-9 pubmed publisher
    ..MAGE-A11 increased Skp2-mediated degradation of cyclin A and retinoblastoma-related protein p130. In contrast, MAGE-A11 decreased Skp2-mediated degradation of E2F1 and Skp2 self-ubiquitination...
  2. Li J, Wang R, Tang D. Vimentin dephosphorylation at ser-56 is regulated by type 1 protein phosphatase in smooth muscle. Respir Res. 2016;17:91 pubmed publisher
    ..Because vimentin phosphorylation is able to modulate p130 Crk-associated substrate (p130CAS) and actin polymerization, we also evaluated the role of PP1 in the biological ..
  3. Elenbaas J, Mouawad R, Henry R, Arnosti D, Payankaulam S. Role of Drosophila retinoblastoma protein instability element in cell growth and proliferation. Cell Cycle. 2015;14:589-97 pubmed publisher
    ..Intriguingly, cancer associated mutations affecting RB homologs p130 and p107 may similarly induce dominant phenotypes.
  4. Pietrzak J, Spickett C, Płoszaj T, Virag L, Robaszkiewicz A. PARP1 promoter links cell cycle progression with adaptation to oxidative environment. Redox Biol. 2018;18:1-5 pubmed publisher
    ..In summary, cell cycle controlled PARP1 transcription helps cells to adapt to a pro-oxidant redox shift. ..
  5. Li F, Tan Y, Chen H, Yan Y, Zhai K, Li D, et al. Identification of schisandrin as a vascular endothelium protective component in YiQiFuMai Powder Injection using HUVECs binding and HPLC-DAD-Q-TOF-MS/MS analysis. J Pharmacol Sci. 2015;129:1-8 pubmed publisher
    ..Nine compounds, which could interact with HUVECs, were identified as ginsenosides Rb1, Rc, Rb2, Rd, 20(S)-Rg3, 20(R)-Rg3, Rk1/Rg5 and schisandrin by comparing with reference substances or literature...
  6. Baade T, Paone C, Baldrich A, Hauck C. Clustering of integrin β cytoplasmic domains triggers nascent adhesion formation and reveals a protozoan origin of the integrin-talin interaction. Sci Rep. 2019;9:5728 pubmed publisher
    ..Proteins indirectly linked to integrins, such as vinculin, migfilin, p130CAS, or zyxin were not enriched around the integrin β1 tail...
  7. Kim J, Kim K, Kim I, Seong S, Nam K, Lee S, et al. Role of CrkII Signaling in RANKL-Induced Osteoclast Differentiation and Function. J Immunol. 2016;196:1123-31 pubmed publisher
    ..Phosphorylation of p130 Crk-associated substrate (p130Cas) by osteoclastogenic cytokines in preosteoclasts increased the interaction ..
  8. Vélez Cruz R, Johnson D. The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts. Int J Mol Sci. 2017;18: pubmed publisher
    ..RB, in some cases, acts through its interaction with E2F1, other members of the pocket protein family (p107 and p130), and/or chromatin remodelers and modifiers...
  9. Kimura M, Mizukami S, Watanabe Y, Hasegawa Baba Y, Onda N, Yoshida T, et al. Disruption of spindle checkpoint function ahead of facilitation of cell proliferation by repeated administration of hepatocarcinogens in rats. J Toxicol Sci. 2015;40:855-71 pubmed publisher
    ..These results suggest that hepatocarcinogens disrupt spindle checkpoint function after 28 or 90 days of administration, which may be induced ahead of cell proliferation facilitation. ..
  10. Zhou Y, Hambly B, McLachlan C. FTO associations with obesity and telomere length. J Biomed Sci. 2017;24:65 pubmed publisher
  11. Agrelo R, Kishimoto H, Novatchkova M, Peraza V, Paolino M, Souabni A, et al. SATB1 collaborates with loss of p16 in cellular transformation. Oncogene. 2013;32:5492-500 pubmed publisher
    ..A combined deletion of the RB proteins, RB, p107 and p130 (triple-mutant; TM), prevents SATB1-induced G1 arrest, which is restored upon the reintroduction of RB into SATB1-..
  12. Song Y, Sullivan T, Klarmann K, Gilbert D, O Sullivan T, Lu L, et al. RB inactivation in keratin 18 positive thymic epithelial cells promotes non-cell autonomous T cell hyperproliferation in genetically engineered mice. PLoS ONE. 2017;12:e0171510 pubmed publisher
    ..TEC was sufficient for thymocyte hyperplasia, we conditionally inactivated Rb and its family members p107 and p130 in K18+ TEC in genetically engineered mice (TgK18GT121; K18 mice)...
  13. Hinrichs B, Matthews J, Siuda D, O Leary M, Wolfarth A, Saeedi B, et al. Serum Amyloid A1 Is an Epithelial Prorestitutive Factor. Am J Pathol. 2018;188:937-949 pubmed publisher
    ..and time dependent and is associated with epithelial reactive oxygen species production and alterations in p130 Crk-associated substrate staining...
  14. Lee J, Jung J, Chae Y, Park H, Kim W, Lee S, et al. Long Noncoding RNA snaR Regulates Proliferation, Migration and Invasion of Triple-negative Breast Cancer Cells. Anticancer Res. 2016;36:6289-6295 pubmed
    ..Among 90 lncRNAs, E2F transcription factor 4, p107/p130-binding (E2F4) antisense, insulin-like growth factor 2 antisense (IGF2AS), snaR, and small nucleolar RNA host gene ..
  15. Stratigopoulos G, Burnett L, Rausch R, Gill R, Penn D, Skowronski A, et al. Hypomorphism of Fto and Rpgrip1l causes obesity in mice. J Clin Invest. 2016;126:1897-910 pubmed publisher
    ..Together, the results of this study indicate that the effects of FTO-associated SNPs on energy homeostasis are due in part to the effects of these genetic variations on hypothalamic FTO, RPGRIP1L, and possibly other genes. ..
  16. Petrov N, Vereschagina N, Sushilova E, Kropotov A, Miheeva N, Popov B. [PRODUCT OF THE BMI1--A KEY COMPONENT OF POLYCOMB--POSITIVELY REGULATES ADIPOCYTE DIFFERENTIATION OF MOUSE MESENCHYMAL STEM CELLS]. Tsitologiia. 2016;58:83-90 pubmed
    ..C3H10T1/2 cell line was associated with an increase in the expression levels of BMI1, the genes of pRb family (RB, p130) and demethylase UTX, but not methyltransferase EZH2, whose products regulate the methylation levels of H3K27...
  17. Burkhart D, Ngai L, Roake C, Viatour P, Thangavel C, Ho V, et al. Regulation of RB transcription in vivo by RB family members. Mol Cell Biol. 2010;30:1729-45 pubmed publisher
    ..Using these reporter mice and mutant alleles for Rb, p107, and p130, we found that RB family members modulate Rb transcription in specific cell populations in vivo and in culture...
  18. Redwood A, Perkins S, VanderWaal R, Feng Z, Biehl K, Gonzalez Suarez I, et al. A dual role for A-type lamins in DNA double-strand break repair. Cell Cycle. 2011;10:2549-60 pubmed
    ..involving transcriptional downregulation of BRCA1 and RAD51 by the repressor complex formed by the Rb family member p130 and E2F4. In line with the DNA repair defects, lamins-deficient cells exhibit increased radiosensitivity...
  19. Schwentner R, Papamarkou T, Kauer M, Stathopoulos V, Yang F, Bilke S, et al. EWS-FLI1 employs an E2F switch to drive target gene expression. Nucleic Acids Res. 2015;43:2780-9 pubmed publisher
    ..in Ewing sarcoma we report replacement of E2F3/pRB by constitutively expressed repressive E2F4/p130 complexes on target genes upon EWS-FLI1 modulation...
  20. Li P, Lv B, Jiang X, Wang T, Ma X, Chang N, et al. Identification of NF-?B inhibitors following Shenfu injection and bioactivity-integrated UPLC/Q-TOF-MS and screening for related anti-inflammatory targets in vitro and in silico. J Ethnopharmacol. 2016;194:658-667 pubmed publisher
    ..The results of high throughput screening (HTS) revealed that protopanaxadiol glycosides (ginsenosides Rb1, Rb2, Rb3, Rc and Rd), protopanaxatriol glycosides (ginsenosides Rg1, Rg2, Re, Rf and F1), diester-type alkaloids (..
  21. Qiang L, Shah P, Barcellos Hoff M, He Y. TGF-β signaling links E-cadherin loss to suppression of nucleotide excision repair. Oncogene. 2016;35:3293-302 pubmed publisher
    ..Loss of E-cadherin activates the E2F4 and p130/107 transcription repressor complexes to suppress the transcription of both XPC and DDB1 through activating the ..
  22. Zhang W, Chen H, Chen Y, Liu J, Wang X, Yu X, et al. Cancerous inhibitor of protein phosphatase 2A contributes to human papillomavirus oncoprotein E7-induced cell proliferation via E2F1. Oncotarget. 2015;6:5253-62 pubmed
    ..significantly upregulating CIP2A mRNA and protein expression depended on retinoblastoma protein pRb rather than p130. CIP2A siRNA knockdown in HPV-E7-expressing cells inhibited cell proliferation, DNA synthesis and G1/S cell cycle ..
  23. Oshikawa M, Okada K, Tabata H, Nagata K, Ajioka I. Dnmt1-dependent Chk1 pathway suppression is protective against neuron division. Development. 2017;144:3303-3314 pubmed publisher
    ..Here, we have found that acute inactivation of retinoblastoma (Rb) family proteins (Rb, p107 and p130) in mouse postmitotic neurons leads to cell death after S-phase progression...
  24. Meng W, Pathak S, Ding Z, Zhang H, Adell G, Holmlund B, et al. Special AT-rich sequence binding protein 1 expression correlates with response to preoperative radiotherapy and clinical outcome in rectal cancer. Cancer Biol Ther. 2015;16:1738-45 pubmed publisher
    ..SATB1 negatively correlated with ataxia telangiectasia mutated (ATM) and pRb2/p130, and positively with Ki-67 and Survivin in RT patients, and their potential interaction through different ..
  25. Tomiatti V, Istvánffy R, Pietschmann E, Kratzat S, Hoellein A, Quintanilla Fend L, et al. Cks1 is a critical regulator of hematopoietic stem cell quiescence and cycling, operating upstream of Cdk inhibitors. Oncogene. 2015;34:4347-57 pubmed publisher
    ..Lin-Sca-1+Kit+ (LSK) HSC, and the loss resulted in accumulation of the SCF(Skp2)/Cks1 substrates p21, p27, p57 and p130 particularly in CD150+ LSK cells...
  26. Chung Y, Kim H, Park S, Yoon J, Kim M, Nam S, et al. Transcriptome analysis reveals that Müllerian inhibiting substance regulates signaling pathways that contribute to endometrial carcinogenesis. Int J Oncol. 2015;46:2039-46 pubmed publisher
    ..apoptotic protease activating factor-1 (APAF-1), β-catenin-interacting protein (ICAT), Rb related protein 130 (p130), and inhibitor of disheveled Dvl and Axin complex (IDAX), were gradually increased over the time of the study, ..
  27. Mele D, Bista P, Baez D, Huber B. Dipeptidyl peptidase 2 is an essential survival factor in the regulation of cell quiescence. Cell Cycle. 2009;8:2425-34 pubmed
    ..A decrease in DPP2 activity was found to cause resting cells to exit from G(0), accompanied by a decrease in p130, p27(Kip1) and p21(Cip1) protein levels...
  28. Shainberg A, Yitzhaki S, Golan O, Jacobson K, Hochhauser E. Involvement of UTP in protection of cardiomyocytes from hypoxic stress. Can J Physiol Pharmacol. 2009;87:287-99 pubmed publisher
    ..trigger a cardioprotective response: a transient increase of [Ca2+]i, an effect that was abolished by PPADS or RB2; phosphorylation of the kinases ERK and Akt, which was abolished by U0126 and LY294002, respectively; and reduced ..
  29. Cox C, Mandell E, STEWART L, Lu R, Johnson D, McCarter S, et al. Endosomal regulation of contact inhibition through the AMOT:YAP pathway. Mol Biol Cell. 2015;26:2673-84 pubmed publisher
    ..This increase in proliferation is dependent upon YAP activity and is complemented by overexpression of p130-AMOT. Furthermore, overexpression of EDTB inhibits the AMOT:YAP interaction...
  30. Ma L, Liu F, Zhong Z, Wan J. Comparative study on chemical components and anti-inflammatory effects of Panax notoginseng flower extracted by water and methanol. J Sep Sci. 2017;40:4730-4739 pubmed publisher
    ..Specifically, the major components of Panax notoginseng flower, ginsenosides Rb1, Rc, Rb2, Rb3, and Rd, can be near completely transformed to the minor components, gypenoside XVII, notoginsenoside Fe, ..
  31. Schroder E, Klamer Z, Saral A, Sugg K, June C, Wymore T, et al. Clinical Variants of the Native Class D ?-Lactamase of Acinetobacter baumannii Pose an Emerging Threat through Increased Hydrolytic Activity against Carbapenems. Antimicrob Agents Chemother. 2016;60:6155-64 pubmed publisher
    ..Molecular dynamics simulations show that in OXA-66, P130 inhibits the side-chain rotation of I129 and thereby prevents doripenem binding because of steric clash...
  32. Zerr I, Zafar S, Schmitz M, Llorens F. Cerebrospinal fluid in Creutzfeldt-Jakob disease. Handb Clin Neurol. 2017;146:115-124 pubmed publisher
    ..First observations were made using two-dimensional gel electrophoresis for proteins named p130/131, identified as belonging to the 14-3-3 protein family group...
  33. Qiang L, Zhao B, Shah P, Sample A, Yang S, He Y. Autophagy positively regulates DNA damage recognition by nucleotide excision repair. Autophagy. 2016;12:357-68 pubmed publisher
    ..These findings demonstrate the crucial role of autophagy in maintaining proper nucleotide excision repair in mammalian cells and suggest a previously unrecognized tumor-suppressive mechanism of autophagy in cancer. ..
  34. Ortiz A, Lee Y, Yu G, Liu H, Lin S, Bilen M, et al. Angiomotin is a novel component of cadherin-11/β-catenin/p120 complex and is critical for cadherin-11-mediated cell migration. FASEB J. 2015;29:1080-91 pubmed publisher
    ..Further, Cad11 preferentially interacts with Amot-p80 than Amot-p130 isoform and binds directly to the middle domain of Amot-p80...
  35. Radulescu R. The nucleocrine pathway comes of age. Rom J Morphol Embryol. 2015;56:343-8 pubmed
    ..obtained as to the intranuclear presence of the previously surmised heterodimer between the EGF precursor and the p130 tumor suppressor...
  36. Alvaro Blanco J, Urso K, Chiodo Y, Martín Cortázar C, Kourani O, Arco P, et al. MAZ induces MYB expression during the exit from quiescence via the E2F site in the MYB promoter. Nucleic Acids Res. 2017;45:9960-9975 pubmed publisher
    ..Moreover, while forced RB or p130 expression repressed the activity of a luciferase reporter driven by the MYB-E2F element, co-expression of MAZ ..
  37. Chudasama P, Mughal S, Sanders M, Hübschmann D, Chung I, Deeg K, et al. Integrative genomic and transcriptomic analysis of leiomyosarcoma. Nat Commun. 2018;9:144 pubmed publisher
    ..This comprehensive study of LMS genomics has uncovered key biological features that may inform future experimental research and enable the design of novel therapies. ..
  38. Mushtaq M, Gaza H, Kashuba E. Role of the RB-Interacting Proteins in Stem Cell Biology. Adv Cancer Res. 2016;131:133-57 pubmed publisher
    ..In this review we have focused on 27 RB-binding partners that may have potential roles in different aspects of stem cell biology. ..
  39. Zeng H, Ortiz A, Shen P, Cheng C, Lee Y, Yu G, et al. Angiomotin regulates prostate cancer cell proliferation by signaling through the Hippo-YAP pathway. Oncotarget. 2017;8:10145-10160 pubmed publisher
    ..We found that AMOTp80, but not AMOT p130, functioned as a tumor promoter by enhancing PCa cell proliferation...
  40. Basagiannis D, Christoforidis S. Constitutive Endocytosis of VEGFR2 Protects the Receptor against Shedding. J Biol Chem. 2016;291:16892-903 pubmed publisher
    ..fragment (100 kDa, s100), which is released in the extracellular space, and a residual C-terminal part (130 kDa, p130) that remains integrated at the plasma membrane...
  41. Berrios C, Jung J, Primi B, Wang M, Pedamallu C, Duke F, et al. Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors. J Virol. 2015;89:857-62 pubmed publisher
    ..The MWPyV small T antigen (ST) binds protein phosphatase 2A (PP2A), and the large T antigen (LT) binds pRb, p107, p130, and p53...
  42. Lai K, Liu Y, Su J, El Shazly M, Wu C, Du Y, et al. Antileukemic Scalarane Sesterterpenoids and Meroditerpenoid from Carteriospongia (Phyllospongia) sp., Induce Apoptosis via Dual Inhibitory Effects on Topoisomerase II and Hsp90. Sci Rep. 2016;6:36170 pubmed publisher
    ..The expression of Hsp90 client proteins, Akt, p70S6k, NF?B, Raf-1, p-GSK3?, and XIAP, MDM 2 and Rb2, and CDK4 and Cyclin D3, HIF 1 and HSF1 were suppressed by the use of 1...
  43. Ullah F, Khan T, Ali N, Malik F, Kayani M, Shah S, et al. Promoter Methylation Status Modulate the Expression of Tumor Suppressor (RbL2/p130) Gene in Breast Cancer. PLoS ONE. 2015;10:e0134687 pubmed publisher
    ..Aberrant expression of tumor suppressor genes may correspond to the abnormal cell development and tumorigenesis. Rbl2/p130, a member of retinoblastoma family of proteins, has growth suppressive properties...
  44. Cross A, Wilson A, Guerrero M, Thomas K, Bachir A, Kubow K, et al. Breast cancer antiestrogen resistance 3-p130Cas interactions promote adhesion disassembly and invasion in breast cancer cells. Oncogene. 2016;35:5850-5859 pubmed publisher
    ..One of two established binding partners of BCAR3 is the adaptor molecule, p130Cas...
  45. Kooi I, van Mil S, MacPherson D, Mol B, Moll A, Meijers Heijboer H, et al. Genomic landscape of retinoblastoma in Rb-/- p130-/- mice resembles human retinoblastoma. Genes Chromosomes Cancer. 2017;56:231-242 pubmed publisher
    ..by deleting the genes encoding for retinoblastoma susceptibility protein pRb and one of its family members p107 or p130. In Rb-/- p107-/- retinoblastomas, somatic copy number alterations (SCNAs) like Mdm2 ..
  46. Gao C, Ren S, Wang J, Zhang S, Jin F, Nakajima T, et al. P130 and its truncated form mediate p53-induced cell cycle arrest in Rb(-/-) Saos2 cells. Oncogene. 2002;21:7569-79 pubmed
    ..The induction of several p53-responsive genes as well as a small form of p130 (S-p130) was detected upon p53 activation...
  47. D Andrilli G, Masciullo V, Bagella L, Tonini T, Minimo C, Zannoni G, et al. Frequent loss of pRb2/p130 in human ovarian carcinoma. Clin Cancer Res. 2004;10:3098-103 pubmed
    RB2/p130, a member of the retinoblastoma gene family, maps to human chromosome 16q12.2, a region in which deletions have been found in several human neoplasms including breast, prostatic, and ovarian carcinoma...
  48. Zhang B, Chen W, Roman A. The E7 proteins of low- and high-risk human papillomaviruses share the ability to target the pRB family member p130 for degradation. Proc Natl Acad Sci U S A. 2006;103:437-42 pubmed
    ..Second, we analyzed the ability of wild-type HPV-6 E7 to destabilize the other pRB family members, p107 and p130. HPV-6 E7, like HPV-16 E7, decreased the level of p130 protein...
  49. Cong F, Liu J, Wang C, Yuan Z, Bi L, Liang J, et al. Ginsenoside Rb2 inhibits osteoclast differentiation through nuclear factor-kappaB and signal transducer and activator of transcription protein 3 signaling pathway. Biomed Pharmacother. 2017;92:927-934 pubmed publisher
    Ginsenoside-Rb2 (Rb2) is a 20(S)-protopanaxadiol glycoside extracted from ginseng possessing various bioactivities which has drawn considerable interest regarding the area of bone metabolism...
  50. Li E, Zhang J. Essential role of SH3GL1 in interleukin-6(IL-6)- and vascular endothelial growth factor (VEGF)-triggered p130cas-mediated proliferation and migration of osteosarcoma cells. Hum Cell. 2017;30:300-310 pubmed publisher
    ..and migration are parallel to significant increased expression of SH3GL1 and the phosphorylation level of P130cas...
  51. Kim J, Yi Y, Kim M, Cho J. Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases. J Ginseng Res. 2017;41:435-443 pubmed publisher
    ..have reported that ginsenosides and their metabolites/derivatives-including ginsenoside (G)-Rb1, compound K, G-Rb2, G-Rd, G-Re, G-Rg1, G-Rg3, G-Rg5, G-Rh1, G-Rh2, and G-Rp1-exert anti-inflammatory activities in inflammatory ..
  52. Macaluso M, Cinti C, Russo G, Russo A, Giordano A. pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer. Oncogene. 2003;22:3511-7 pubmed
    ..Here we show a new molecular mechanism of ER-alpha gene inactivation mediated by pRb2/p130 in ER-negative breast cancer cells...
  53. Jiang Y, Saavedra H, Holloway M, Leone G, Altura R. Aberrant regulation of survivin by the RB/E2F family of proteins. J Biol Chem. 2004;279:40511-20 pubmed
    ..We demonstrate that both pRB and p130 can interact with the survivin promoter and can repress survivin transcription...
  54. Lehmann B, Brooks A, Paine M, Chappell W, McCubrey J, Terrian D. Distinct roles for p107 and p130 in Rb-independent cellular senescence. Cell Cycle. 2008;7:1262-8 pubmed
    ..A small family of tumor suppressor genes encoding the retinoblastoma susceptibility protein family (Rb, p107, p130) exerts a partially redundant control of entry into S phase of DNA replication and cellular proliferation...
  55. Rozenblatt Rosen O, Deo R, Padi M, Adelmant G, Calderwood M, Rolland T, et al. Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature. 2012;487:491-5 pubmed publisher
    ..Combining systems-level studies of pathogen-encoded gene products with genomic approaches will facilitate the prioritization of cancer-causing driver genes to advance the understanding of the genetic basis of human cancer...
  56. Soprano K, Purev E, Vuocolo S, Soprano D. Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid. Oncogene. 2006;25:5315-25 pubmed
    ..has been shown to arrest the growth of ovarian carcinoma cells in G0/G1 and to significantly elevate levels of Rb2/p130 protein, a member of the retinoblastoma family of tumor suppressors...
  57. Fiorentino F, Macaluso M, Miranda F, Montanari M, Russo A, Bagella L, et al. CTCF and BORIS regulate Rb2/p130 gene transcription: a novel mechanism and a new paradigm for understanding the biology of lung cancer. Mol Cancer Res. 2011;9:225-33 pubmed publisher
    ..many aspects thereof remain to be addressed, including the role played by the retinoblastoma-related protein Rb2/p130 during the evolution of this disease...
  58. Nor Rashid N, Yong Z, Yusof R, Watson R. HPV 16E7 and 48E7 proteins use different mechanisms to target p130 to overcome cell cycle block. Virol J. 2016;13:2 pubmed publisher
    b>Retinoblastoma like protein 2 (RBL2) or p130 is a member of the pocket protein family, which is infrequently mutated in human tumours. Its expression is posttranscriptionally regulated and largely G0 restricted...
  59. Kochan E, Szymczyk P, Kuźma Ł, Lipert A, Szymanska G. Yeast Extract Stimulates Ginsenoside Production in Hairy Root Cultures of American Ginseng Cultivated in Shake Flasks and Nutrient Sprinkle Bioreactors. Molecules. 2017;22: pubmed publisher
    ..The maximum yield (20 mg g-1 d.w.) of the sum of six examined ginsenosides (Rb1, Rb2, Rc, Rd, Re and Rg1) in hairy roots cultivated in shake flasks was achieved after application of YE at 50 mg L-..
  60. Prathapam T, Kühne C, Banks L. Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity. Nucleic Acids Res. 2002;30:5261-8 pubmed
    ..Taken together, these studies suggest that one potential function of the Skip-Ski complex is to overcome the growth-suppressive activities of pRb. ..
  61. Nozoe T, Korenaga D, Itoh S, Futatsugi M, Maehara Y. Clinicopathological significance of pRb2/p130 expression in squamous cell carcinoma of the esophagus. J Cancer Res Clin Oncol. 2002;128:691-6 pubmed
    The aim of the current study was to find out the significance of the immunohistochemical expression of pRb2/p130, which is a member of the retinoblastoma gene family, in squamous cell carcinoma of the esophagus...
  62. Kong L, Meloni A, Nevins J. The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1. Mol Cell. 2006;22:63-71 pubmed
    ..work has implicated the Rb family of proteins in the control of telomere length, and we now demonstrate that the p130 member of the Rb family is critical for telomere length control...
  63. Barrow Laing L, Chen W, Roman A. Low- and high-risk human papillomavirus E7 proteins regulate p130 differently. Virology. 2010;400:233-9 pubmed publisher
    The E7 protein of high-risk human papillomaviruses (HR HPVs) targets pRb family members (pRb, p107 and p130) for degradation; low-risk (LR) HPV E7 only targets p130 for degradation...
  64. Zhang W, Tian Y, Chen J, Zhao W, Yu X. A postulated role of p130 in telomere maintenance by human papillomavirus oncoprotein E7. Med Hypotheses. 2012;79:178-80 pubmed publisher
    ..We propose that degradation of tumor suppressor pRb family member p130 plays an essential role in E7-regulated telomere extension by ALT...
  65. Hesbacher S, Pfitzer L, Wiedorfer K, Angermeyer S, Borst A, Haferkamp S, et al. RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells. Oncotarget. 2016;7:32956-68 pubmed publisher
    The pocket protein (PP) family consists of the three members RB1, p107 and p130 all possessing tumor suppressive properties. Indeed, the PPs jointly control the G1/S transition mainly by inhibiting E2F transcription factors...
  66. Dai S, Hong Y, Xu J, Lin Y, Si Q, Gu X. Ginsenoside Rb2 promotes glucose metabolism and attenuates fat accumulation via AKT-dependent mechanisms. Biomed Pharmacother. 2018;100:93-100 pubmed publisher
    ..Ginsenoside Rb2 (Rb2) is the most abundant saponin in Panax ginseng, this study investigates the role of Rb2 in the anti-..
  67. Ferreira R, Magnaghi Jaulin L, Robin P, Harel Bellan A, Trouche D. The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase. Proc Natl Acad Sci U S A. 1998;95:10493-8 pubmed
    ..Here, we show that the two other members of the pocket proteins family, p107 and p130, also are able to interact physically with HDAC1 in live cells...
  68. Moparthi S, Bergman V, Adell G, Thorstensson S, Sun X. pRb2/p130 protein in relation to clinicopathological and biological variables in rectal cancers with a clinical trial of preoperative radiotherapy. Int J Colorectal Dis. 2009;24:1303-10 pubmed publisher
    b>pRb2/p130 plays a key role in cell proliferation and is a considerable progress about expression patterns of pRb2/p130 in number of malignancies. However, pRb2/p130 expression and its significance in rectal cancer remain unknown...
  69. Xue M, Yang L, Shi D, Radauer C, Breiteneder H, Ma Y. Qualitative analysis of xinyue capsules by high-performance liquid chromatography: Preliminary evaluation of drug quality in a Sino-Austrian joint study. Chin J Integr Med. 2015;21:772-7 pubmed publisher
    ..liquid chromatography ultraviolet (HPLC-UV) method was established to analyse six main ginsenosides (Rb1, Rb2, Rc, Rd, Re and Rg1) in six different batches (120 capsules/batch) from the same lot of xinyue capsules and in one ..
  70. Fischer M, Quaas M, Nickel A, Engeland K. Indirect p53-dependent transcriptional repression of Survivin, CDC25C, and PLK1 genes requires the cyclin-dependent kinase inhibitor p21/CDKN1A and CDE/CHR promoter sites binding the DREAM complex. Oncotarget. 2015;6:41402-17 pubmed publisher
    ..Chromatin immunoprecipitation (ChIP) data indicate that promoter binding of B-MYB switches to binding of E2F4 and p130 resulting in a replacement of the MMB (Myb-MuvB) by the DREAM complex...
  71. Seawright J, Trache A, Wilson E, Woodman C. Short-duration increases in intraluminal pressure improve vasoconstrictor responses in aged skeletal muscle feed arteries. Eur J Appl Physiol. 2016;116:931-7 pubmed publisher
    ..Following the 1-h treatment, pressure in P130 arteries was lowered to 90 cmH2O for examination of vasoconstrictor responses to norepinephrine (NE), ..
  72. Uchida C, Miwa S, Kitagawa K, Hattori T, Isobe T, Otani S, et al. Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation. EMBO J. 2005;24:160-9 pubmed
    ..Downregulation of pRB expression was correlated with a high level of expression of Mdm2 in human lung cancers. These results suggest that Mdm2 regulates function of pRB via ubiquitin-dependent degradation of pRB. ..
  73. Helmbold H, Komm N, Deppert W, Bohn W. Rb2/p130 is the dominating pocket protein in the p53-p21 DNA damage response pathway leading to senescence. Oncogene. 2009;28:3456-67 pubmed publisher
    ..we show that in a broad range of wild-type p53-expressing human tumor cells, and in human diploid fibroblasts, Rb2/p130 is the dominating pocket protein in replicative and in accelerated senescence...
  74. Seawright J, Luttrell M, Trache A, Woodman C. Short-term increases in pressure and shear stress attenuate age-related declines in endothelial function in skeletal muscle feed arteries. Eur J Appl Physiol. 2016;116:1305-11 pubmed publisher
    ..SFA from young (4 months) and old (24 months) Fischer 344 rats were cannulated and pressurized at 90 (P90) or 130 (P130) cmH2O and exposed to no SS (0 dyn/cm(2)) or high SS (~65 dyn/cm(2)) for 1 h...
  75. Shigeno Nakazawa Y, Kasai T, Ki S, Kostyanovskaya E, Pawlak J, Yamagishi J, et al. A pre-metazoan origin of the CRK gene family and co-opted signaling network. Sci Rep. 2016;6:34349 pubmed publisher
    ..the mammalian CRK/CRKL SH2 binding consensus phospho-YxxP, and to the SRC substrate/focal adhesion protein BCAR1 (p130CAS) in the presence of activated SRC...
  76. Zhou X, Chen L, Xie R, Lam W, Zhang Z, Jiang Z, et al. Chemosynthesis pathway and bioactivities comparison of saponins in radix and flower of Panax notoginseng (Burk.) F.H. Chen. J Ethnopharmacol. 2017;201:56-72 pubmed publisher
    ..contents of Rg1, Rb1, Re, R1, Rg3-20R, Rh1 and Rf in radix are abundant; in contrast, the contents of Rb3, Fc, Ft1, Rb2 and Rh2-20s in flowers are plentiful...
  77. Cavallotti I, De Luca L, D Aponte A, De Falco M, Acanfora F, Visciano M, et al. Expression of the retinoblastoma-related p107 and Rb2/p130 genes in human placenta: an immunohistochemical study. Histol Histopathol. 2001;16:1057-60 pubmed publisher
    ..p107 and pRb2/p130 showed the most abundant expression levels during the first trimester of gestation and progressively declined ..
  78. Farkas T, Hansen K, Holm K, Lukas J, Bartek J. Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4. J Biol Chem. 2002;277:26741-52 pubmed
    The "pocket proteins" pRb (retinoblastoma tumor suppressor protein), p107, and p130 regulate cell proliferation via phosphorylation-sensitive interactions with E2F transcription factors and other proteins...
  79. Los A, Vinke F, de Widt J, Topham M, van Blitterswijk W, Divecha N. The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta. J Biol Chem. 2006;281:858-66 pubmed
    ..DGKzeta also binds to the pRB-related pocket proteins p107 and p130 in vitro and in cells...
  80. Jiao X, Lu X, Chen A, Luo Y, Hao J, Gao W. Effects of Fusarium solani and F. oxysporum Infection on the Metabolism of Ginsenosides in American Ginseng Roots. Molecules. 2015;20:10535-52 pubmed publisher
    ..oxysporum) and the levels of six ginsenosides (Rb1, Rb2, Rc, Rd, Re, and Rg1) were then measured in the phloem and xylem around the discolored lesions and adjacent healthy ..
  81. Orlando S, Gallastegui E, Besson A, Abril G, Aligué R, Pujol M, et al. p27Kip1 and p21Cip1 collaborate in the regulation of transcription by recruiting cyclin-Cdk complexes on the promoters of target genes. Nucleic Acids Res. 2015;43:6860-73 pubmed publisher
    Transcriptional repressor complexes containing p130 and E2F4 regulate the expression of genes involved in DNA replication...
  82. Hoe S, Lee E, Khoo A, Peh S. Lack of Rb2/p130 genetic alteration in Malaysian nasopharyngeal carcinoma. Malays J Pathol. 2009;31:53-6 pubmed
    The retinoblastoma-related gene Rb2/p130 has been reported to be mutated in several malignancies such as lung cancer and Burkitt's lymphoma...
  83. Kalungi S, Wabinga H, Bostad L. The RB (pRb2/p16) and p53 (p14/p53/p21) tumor-suppressor pathways in endemic Burkitt lymphoma. J Pediatr Hematol Oncol. 2011;33:e54-9 pubmed publisher
    ..The aim of the study was to examine the expression profile of the RB (pRb2 or p16) and p53 (p53, p14, or p21) pathways in biopsies of endemic BL, and compare it to the pattern found in ..
  84. Dyson N, Guida P, M nger K, Harlow E. Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins. J Virol. 1992;66:6893-902 pubmed
    ..to pRB binding, these regions are necessary for E1A association with several other cellular proteins, including p130, p107, cyclin A, and p33cdk2...
  85. Iavarone A, Massague J. E2F and histone deacetylase mediate transforming growth factor beta repression of cdc25A during keratinocyte cell cycle arrest. Mol Cell Biol. 1999;19:916-22 pubmed
    ..that the cell cycle arrest program activated by TGF-beta in human keratinocytes includes the generation of E2F4-p130 complexes that in association with histone deacetylase HDAC1 inhibit the activity of the cdc25A promoter from this ..
  86. Zini N, Trimarchi C, Claudio P, Stiegler P, Marinelli F, Maltarello M, et al. pRb2/p130 and p107 control cell growth by multiple strategies and in association with different compartments within the nucleus. J Cell Physiol. 2001;189:34-44 pubmed
    ..In a first series of experiments, we showed that pRb2/p130 and p107 are not evenly distributed within the nucleus and that cell cycle-dependent binding with E2F4 changes also ..
  87. Weinmann A, Yan P, Oberley M, Huang T, Farnham P. Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. Genes Dev. 2002;16:235-44 pubmed
    ..We suggest that human CpG microarrays, in combination with chromatin immunoprecipitation, will allow rapid identification of target promoters for many mammalian transcription factors. ..
  88. Garriga J, Jayaraman A, Limon A, Jayadeva G, Sotillo E, Truongcao M, et al. A dynamic equilibrium between CDKs and PP2A modulates phosphorylation of pRB, p107 and p130. Cell Cycle. 2004;3:1320-30 pubmed
    ..Moreover, dephosphorylation of p130 and p107 in cell extracts is inhibited by concentrations of okadaic acid known to inhibit PP2A, but not PP1...
  89. Zargar Z, Kimidi M, Tyagi S. Dynamic site-specific recruitment of RBP2 by pocket protein p130 modulates H3K4 methylation on E2F-responsive promoters. Nucleic Acids Res. 2017;: pubmed publisher
    ..of removing tri-methylation marks on H3K4, associates with the E2F4 transcription factor via the pocket protein-p130-in a cell-cycle-stage specific manner. The association of RBP2 with p130 is LxCxE motif dependent...
  90. D Souza S, Pajak A, Balazsi K, Dagnino L. Ca2+ and BMP-6 signaling regulate E2F during epidermal keratinocyte differentiation. J Biol Chem. 2001;276:23531-8 pubmed
    ..E2F-5 up-regulation is also accompanied by formation of heteromeric nuclear complexes containing E2F5, p130, and histone deacetylase (HDAC) 1...
  91. Miles W, Korenjak M, Griffiths L, Dyer M, Provero P, Dyson N. Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells. EMBO J. 2014;33:2201-15 pubmed publisher
    ..Our data suggest that NANOS increases in importance in pRb-deficient cells and helps to maintain homeostasis by repressing the translation of transcripts containing PUM Regulatory Elements (PRE). ..
  92. De Falco G, Bellan C, Lazzi S, Claudio P, La Sala D, Cinti C, et al. Interaction between HIV-1 Tat and pRb2/p130: a possible mechanism in the pathogenesis of AIDS-related neoplasms. Oncogene. 2003;22:6214-9 pubmed
    ..Among these genes, it has recently been shown that pRb2/p130 oncosuppressor protein is one of the targets in the interaction between HIV gene product Tat and host proteins...