p120ctn

Summary

Gene Symbol: p120ctn
Description: catenin delta 1
Alias: BCDS2, CAS, CTNND, P120CAS, P120CTN, p120, p120(CAS), p120(CTN), catenin delta-1, cadherin-associated Src substrate, catenin (cadherin-associated protein), delta 1, p120 catenin
Species: human
Products:     p120ctn

Top Publications

  1. Daniel J, Reynolds A. The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. Mol Cell Biol. 1999;19:3614-23 pubmed
    b>p120(ctn) is an Armadillo repeat domain protein with structural similarity to the cell adhesion cofactors beta-catenin and plakoglobin...
  2. Mortazavi F, An J, Dubinett S, Rettig M. p120-catenin is transcriptionally downregulated by FOXC2 in non-small cell lung cancer cells. Mol Cancer Res. 2010;8:762-74 pubmed publisher
    p120-catenin (p120ctn) plays a major role in cell adhesion and motility through the regulation of E-cadherin and interaction with RhoGTPase and Rac1...
  3. Miao Y, Liu N, Zhang Y, Liu Y, Yu J, Dai S, et al. p120ctn isoform 1 expression significantly correlates with abnormal expression of E-cadherin and poor survival of lung cancer patients. Med Oncol. 2010;27:880-6 pubmed publisher
    ..While the mean survival times of patients with normal p120 ctn isoform 1 or pan-p120ctn expression differed significantly, the mean survival times of patients with abnormal ..
  4. Mayerle J, Friess H, Buchler M, Schnekenburger J, Weiss F, Zimmer K, et al. Up-regulation, nuclear import, and tumor growth stimulation of the adhesion protein p120 in pancreatic cancer. Gastroenterology. 2003;124:949-60 pubmed
    ..We have studied the role of p120(ctn), a recently discovered member of the cadherin/catenin family, in human pancreatic cancer...
  5. Cheung L, Leung P, Wong A. Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropin-releasing hormone to promote tumor cell migration and invasion in ovarian cancer. Oncogene. 2010;29:2427-40 pubmed publisher
    ..effects of P-cadherin were mediated by activation of the Rho GTPases, Rac1, and Cdc42, through accumulation of p120 catenin (p120(ctn)) in the cytoplasm...
  6. Davis M, Ireton R, Reynolds A. A core function for p120-catenin in cadherin turnover. J Cell Biol. 2003;163:525-34 pubmed
    b>p120-catenin stabilizes epithelial cadherin (E-cadherin) in SW48 cells, but the mechanism has not been established. Here, we show that p120 acts at the cell surface to control cadherin turnover, thereby regulating cadherin levels...
  7. Xiao K, Allison D, Buckley K, Kottke M, Vincent P, Faundez V, et al. Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells. J Cell Biol. 2003;163:535-45 pubmed
    ..The mechanisms by which catenins regulate cadherin function are not fully understood, and the precise function of p120 catenin (p120ctn) has remained particularly elusive...
  8. Kelly K, Otchere A, Graham M, Daniel J. Nuclear import of the BTB/POZ transcriptional regulator Kaiso. J Cell Sci. 2004;117:6143-52 pubmed
    ..The identification of a Kaiso NLS thus clarifies the mechanism by which Kaiso translocates to the nucleus to regulate transcription of genes with diverse roles in cell growth and development. ..
  9. Ogden S, Wroblewski L, Weydig C, Romero Gallo J, O Brien D, Israel D, et al. p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7. Mol Biol Cell. 2008;19:4110-21 pubmed publisher
    ..We now report that H. pylori-mediated mmp-7 induction is transcriptionally regulated via aberrant activation of p120-catenin (p120), a component of adherens junctions. H...

More Information

Publications74

  1. Reynolds A, Carnahan R. Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer. Semin Cell Dev Biol. 2004;15:657-63 pubmed
    ..b>p120ctn has been indirectly implicated in clustering for some time, but it now appears that its main function is to ..
  2. Ohkubo T, Ozawa M. p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity. J Biol Chem. 1999;274:21409-15 pubmed
    ..In this report, we provide several lines of evidence that p120(ctn) is involved in this negative regulation...
  3. Wijnhoven B, Dinjens W, Pignatelli M. E-cadherin-catenin cell-cell adhesion complex and human cancer. Br J Surg. 2000;87:992-1005 pubmed
    ..Further studies may yield greater insight into the early molecular interactions critical to the initiation and progression of tumours. This should aid the development of novel strategies for both prevention and treatment of cancer. ..
  4. Kinch M, Clark G, Der C, Burridge K. Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia. J Cell Biol. 1995;130:461-71 pubmed
    ..Whereas in the normal cells beta-catenin is found in association with E-cadherin, p120 Cas is not...
  5. Menke A, Giehl K. Regulation of adherens junctions by Rho GTPases and p120-catenin. Arch Biochem Biophys. 2012;524:48-55 pubmed publisher
    ..will summarize the current findings about the influence of Rho GTPases on the formation and maintenance of adherens junction and will then proceed to discuss the involvement of p120-catenin on cell-cell adhesion and tumor cell migration.
  6. Schackmann R, van Amersfoort M, Haarhuis J, Vlug E, Halim V, Roodhart J, et al. Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance. J Clin Invest. 2011;121:3176-88 pubmed publisher
    ..Using a mouse model of human ILC, we show here that cytosolic p120-catenin (p120) regulates tumor growth upon loss of E-cadherin through the induction of anoikis resistance...
  7. Ishiyama N, Lee S, Liu S, Li G, Smith M, Reichardt L, et al. Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion. Cell. 2010;141:117-28 pubmed publisher
    The association of p120 catenin (p120) with the juxtamembrane domain (JMD) of the cadherin cytoplasmic tail is critical for the surface stability of cadherin-catenin cell-cell adhesion complexes...
  8. Kiss A, Troyanovsky R, Troyanovsky S. p120-catenin is a key component of the cadherin-gamma-secretase supercomplex. Mol Biol Cell. 2008;19:4042-50 pubmed publisher
    In this work, we show several previously unknown features of p120-catenin in a cadherin-catenin complex that are critical for our understanding of cadherin-based adhesion and signaling...
  9. Kim K, Sirota A, Chen Yh Y, Jones S, Dudek R, Lanford G, et al. Dendrite-like process formation and cytoskeletal remodeling regulated by delta-catenin expression. Exp Cell Res. 2002;275:171-84 pubmed
    ..Here we show that the expression of delta-catenin (or NPRAP/Neurojungin), a member of p120(ctn) subfamily of armadillo proteins can induce the branching of dendrite-like processes in 3T3 cells and enhance ..
  10. Thoreson M, Anastasiadis P, Daniel J, Ireton R, Wheelock M, Johnson K, et al. Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion. J Cell Biol. 2000;148:189-202 pubmed
    b>p120(ctn) is a catenin whose direct binding to the juxtamembrane domain of classical cadherins suggests a role in regulating cell-cell adhesion...
  11. Daniel J, Reynolds A. The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin. Mol Cell Biol. 1995;15:4819-24 pubmed
    The tyrosine kinase substrate p120cas (CAS), which is structurally similar to the cell adhesion proteins beta-catenin and plakoglobin, was recently shown to associate with the E-cadherin-catenin cell adhesion complex...
  12. Macpherson I, Hooper S, Serrels A, McGarry L, Ozanne B, Harrington K, et al. p120-catenin is required for the collective invasion of squamous cell carcinoma cells via a phosphorylation-independent mechanism. Oncogene. 2007;26:5214-28 pubmed
    ..b>p120-catenin has emerged as a key player in promoting E-cadherin stability and adherens junction integrity and has been ..
  13. Herron C, Lowery A, Hollister P, Reynolds A, Vincent P. p120 regulates endothelial permeability independently of its NH2 terminus and Rho binding. Am J Physiol Heart Circ Physiol. 2011;300:H36-48 pubmed publisher
    The association of p120-catenin (p120) with the juxtamembrane domain (JMD) of vascular endothelial (VE)-cadherin is required to maintain VE-cadherin levels and transendothelial resistance (TEER) of endothelial cell monolayers...
  14. Spring C, Kelly K, O Kelly I, Graham M, Crawford H, Daniel J. The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin. Exp Cell Res. 2005;305:253-65 pubmed
    ..Kaiso was first identified as a specific binding partner for the Armadillo catenin and cell adhesion cofactor, p120ctn. Kaiso is a unique POZ protein with bi-modal DNA-binding properties; it associates with a sequence-specific DNA ..
  15. Laura R, Witt A, Held H, Gerstner R, Deshayes K, Koehler M, et al. The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF. J Biol Chem. 2002;277:12906-14 pubmed
    ..These peptides most closely resembled the C-terminal PDZ domain-binding motifs of three p120-related catenins: delta-catenin, ARVCF, and p0071 (DSWV-COOH)...
  16. Jiang G, Wang Y, Dai S, Liu Y, Stoecker M, Wang E, et al. P120-catenin isoforms 1 and 3 regulate proliferation and cell cycle of lung cancer cells via ?-catenin and Kaiso respectively. PLoS ONE. 2012;7:e30303 pubmed publisher
    The different mechanisms involved in p120-catenin (p120ctn) isoforms' 1/3 regulation of cell cycle progression are still not elucidated to date...
  17. Ferreri D, Minnear F, Yin T, Kowalczyk A, Vincent P. N-cadherin levels in endothelial cells are regulated by monolayer maturity and p120 availability. Cell Commun Adhes. 2008;15:333-49 pubmed publisher
    ..Experiments in which p120, a catenin that binds N- and VE-cadherin, was knocked down or overexpressed indicate that these two cadherins ..
  18. Yu J, Miao Y, Xu H, Liu Y, Jiang G, Stoecker M, et al. N-terminal 1-54 amino acid sequence and Armadillo repeat domain are indispensable for P120-catenin isoform 1A in regulating E-cadherin. PLoS ONE. 2012;7:e37008 pubmed publisher
    P120-catenin (p120ctn) exerts important roles in regulating E-cadherin and invasiveness in cancer cells. However, the mechanisms by which p120ctn isoforms 1 and 3 modulate E-cadherin expression are poorly understood...
  19. Aono S, Nakagawa S, Reynolds A, Takeichi M. p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells. J Cell Biol. 1999;145:551-62 pubmed
    b>p120(ctn) binds to the cytoplasmic domain of cadherins but its role is poorly understood. Colo 205 cells grow as dispersed cells despite their normal expression of E-cadherin and catenins...
  20. Nanes B, Chiasson MacKenzie C, Lowery A, Ishiyama N, Faundez V, Ikura M, et al. p120-catenin binding masks an endocytic signal conserved in classical cadherins. J Cell Biol. 2012;199:365-80 pubmed publisher
    b>p120-catenin (p120) binds to the cytoplasmic tails of classical cadherins and inhibits cadherin endocytosis...
  21. Hazan R, Norton L. The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton. J Biol Chem. 1998;273:9078-84 pubmed
    ..of E-cadherin or catenin expression nor the association of catenins (beta-catenin, plakoglobin/gamma-catenin, or p120(cas)) with E-cadherin...
  22. Lampugnani M, Corada M, Andriopoulou P, Esser S, Risau W, Dejana E. Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells. J Cell Sci. 1997;110 ( Pt 17):2065-77 pubmed
    ..Tyrosine phosphorylation of VE-cadherin, beta-catenin and p120, occurred in looser AJ, i.e. in recently confluent cells, and was notably reduced in tightly confluent cultures...
  23. Reynolds A, Daniel J, Mo Y, Wu J, Zhang Z. The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts. Exp Cell Res. 1996;225:328-37 pubmed
    b>p120cas (CAS) is a tyrosine kinase substrate whose phosphorylation has been implicated in cell transformation by Src and in ligand-induced signaling through the EGF, PDGF, and CSF-1 receptors...
  24. Zhang J, O Donnell J, Holian O, Vincent P, Kim K, Lum H. P120 catenin represses transcriptional activity through Kaiso in endothelial cells. Microvasc Res. 2010;80:233-9 pubmed publisher
    b>P120 catenin (p120ctn) belongs to the family of Armadillo repeat-containing proteins, which are believed to have dual functions of cell-cell adhesion and transcriptional regulation...
  25. Fukumoto Y, Shintani Y, Reynolds A, Johnson K, Wheelock M. The regulatory or phosphorylation domain of p120 catenin controls E-cadherin dynamics at the plasma membrane. Exp Cell Res. 2008;314:52-67 pubmed
    In contrast to growth factor-stimulated tyrosine phosphorylation of p120, its relatively constitutive serine/threonine phosphorylation is not well understood...
  26. Yanagisawa M, Anastasiadis P. p120 catenin is essential for mesenchymal cadherin-mediated regulation of cell motility and invasiveness. J Cell Biol. 2006;174:1087-96 pubmed
    ..We show that both p120 catenin and mesenchymal cadherins are required for the invasiveness of E-cadherin-deficient cells...
  27. Liu Y, Li Q, Miao Y, Xu H, Dai S, Wei Q, et al. Ablation of p120-catenin enhances invasion and metastasis of human lung cancer cells. Cancer Sci. 2009;100:441-8 pubmed publisher
    b>p120-catenin, a member of the Armadillo gene family, has emerged as both a master regulator of cadherin stability and an important modulator of small GTPase activities...
  28. Molina Ortiz I, Bartolomé R, Hernández Varas P, Colo G, Teixido J. Overexpression of E-cadherin on melanoma cells inhibits chemokine-promoted invasion involving p190RhoGAP/p120ctn-dependent inactivation of RhoA. J Biol Chem. 2009;284:15147-57 pubmed publisher
    ..Furthermore, we show that p190RhoGAP and p120ctn associated predominantly on the plasma membrane of cells overexpressing E-cadherin, and that E-cadherin-bound ..
  29. Zhang P, Wang Y, Liu Y, Jiang G, Li Q, Wang E. p120-catenin isoform 3 regulates subcellular localization of Kaiso and promotes invasion in lung cancer cells via a phosphorylation-dependent mechanism. Int J Oncol. 2011;38:1625-35 pubmed publisher
    b>p120-catenin regulates E-cadherin stability at the plasma membrane as well as Rho GTPase activity in the cytoplasm, and also interacts with the transcriptional repressor, Kaiso, in the nucleus...
  30. Shibata T, Kokubu A, Sekine S, Kanai Y, Hirohashi S. Cytoplasmic p120ctn regulates the invasive phenotypes of E-cadherin-deficient breast cancer. Am J Pathol. 2004;164:2269-78 pubmed
    ..frequently inactivated, and found that E-cadherin down-regulation correlated with the cytoplasmic localization of p120ctn. Similar cytoplasmic localization of p120ctn and growth factor-induced accumulation of tyrosine-phosphorylated ..
  31. Xia X, Mariner D, Reynolds A. Adhesion-associated and PKC-modulated changes in serine/threonine phosphorylation of p120-catenin. Biochemistry. 2003;42:9195-204 pubmed
    b>p120-catenin (p120) was originally identified as a tyrosine kinase substrate, and subsequently shown to regulate cadherin-mediated cell-cell adhesion...
  32. Burger M, Tebay M, Keith P, Samaratunga H, Clements J, Lavin M, et al. Expression analysis of delta-catenin and prostate-specific membrane antigen: their potential as diagnostic markers for prostate cancer. Int J Cancer. 2002;100:228-37 pubmed
    ..Thus we have identified delta-catenin (not previously associated with prostatic adenocarcinoma) and confirmed the potential of PSMA as potential candidates for the diagnosis and management of prostate cancer. ..
  33. Hülsken J, Birchmeier W, Behrens J. E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J Cell Biol. 1994;127:2061-9 pubmed
  34. Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N, et al. Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes. J Cell Biol. 1995;128:949-57 pubmed
    b>p120 was originally identified as a substrate of pp60src and several receptor tyrosine kinases, but its function is not known...
  35. Tanahashi H, Tabira T. Isolation of human delta-catenin and its binding specificity with presenilin 1. Neuroreport. 1999;10:563-8 pubmed
    ..These results suggest that PS1 and PS2 partly differ in function. PS1 loop fragment containing the pathogenic mutation retained the binding ability. We also found another armadillo-protein, p0071, interacted with PS1. ..
  36. van Hengel J, Vanhoenacker P, Staes K, van Roy F. Nuclear localization of the p120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression. Proc Natl Acad Sci U S A. 1999;96:7980-5 pubmed
    The Armadillo protein p120(ctn) associates with the cytoplasmic domain of cadherins and accumulates at cell-cell junctions...
  37. Talvinen K, Tuikkala J, Nykanen M, Nieminen A, Anttinen J, Nevalainen O, et al. Altered expression of p120catenin predicts poor outcome in invasive breast cancer. J Cancer Res Clin Oncol. 2010;136:1377-87 pubmed publisher
    ..We observed altered expression of p120catenin isoforms in invasive breast cancer and, in our material, the decrease in p120 immunoexpression was significantly associated with poor outcome of disease.
  38. Petrova Y, Spano M, Gumbiner B. Conformational epitopes at cadherin calcium-binding sites and p120-catenin phosphorylation regulate cell adhesion. Mol Biol Cell. 2012;23:2092-108 pubmed publisher
    ..Activation also induces p120-catenin dephosphorylation, as well as changes in the cadherin cytoplasmic domain...
  39. Smith A, Dohn M, Brown M, Reynolds A. Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin. Mol Biol Cell. 2012;23:99-110 pubmed publisher
    ..b>p120-catenin (p120) regulates both cadherin stability and actin dynamics, but the relationship between these two ..
  40. Ireton R, Davis M, van Hengel J, Mariner D, Barnes K, Thoreson M, et al. A novel role for p120 catenin in E-cadherin function. J Cell Biol. 2002;159:465-76 pubmed
    Indirect evidence suggests that p120-catenin (p120) can both positively and negatively affect cadherin adhesiveness...
  41. Paredes J, Correia A, Ribeiro A, Schmitt F. Expression of p120-catenin isoforms correlates with genomic and transcriptional phenotype of breast cancer cell lines. Cell Oncol. 2007;29:467-76 pubmed
    b>P120-catenin is a member of the Armadillo protein family, which is involved in intercellular adhesion and cell signalling...
  42. Wahl J, Kim Y, Cullen J, Johnson K, Wheelock M. N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane. J Biol Chem. 2003;278:17269-76 pubmed
    ..In addition, we show that beta-catenin and plakoglobin associate only with phosphorylated proN-cadherin, whereas p120(ctn) can associate with both phosphorylated and non-phosphorylated proN-cadherin...
  43. Martinez M, Ochiishi T, Majewski M, Kosik K. Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho. J Cell Biol. 2003;162:99-111 pubmed
    ..We conclude that delta-catenin contributes to setting a balance between neurite elongation and branching in the elaboration of a complex dendritic tree. ..
  44. Franz C, Ridley A. p120 catenin associates with microtubules: inverse relationship between microtubule binding and Rho GTPase regulation. J Biol Chem. 2004;279:6588-94 pubmed
    b>p120 catenin (p120ctn), an armadillo protein and component of the cadherin adhesion complex, has been found recently to induce a dendritic morphology by regulating Rho family GTPases...
  45. Hamada S, Satoh K, Miura S, Hirota M, Kanno A, Masamune A, et al. miR-197 induces epithelial-mesenchymal transition in pancreatic cancer cells by targeting p120 catenin. J Cell Physiol. 2013;228:1255-63 pubmed publisher
    ..cells resulted in the induction of epithelial-mesenchymal transition (EMT) along with the down-regulation of p120 catenin which is a putative target of miR-197...
  46. Hong J, Park J, Cho K, Gu D, Ji H, Artandi S, et al. Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members. J Cell Sci. 2010;123:4351-65 pubmed publisher
    ..embryos and mammalian cell lines, we report that the degradation machinery of the canonical Wnt pathway modulates p120-catenin protein stability through mechanisms shared with those regulating ?-catenin...
  47. Zondag G, Reynolds A, Moolenaar W. Receptor protein-tyrosine phosphatase RPTPmu binds to and dephosphorylates the catenin p120(ctn). J Biol Chem. 2000;275:11264-9 pubmed
    ..Here we show that RPTPmu associates with the catenin p120(ctn), a tyrosine kinase substrate and an interacting partner of cadherins...
  48. Zhai B, Yan H, Liu S, Chen L, Wu M, Wang H. Reduced expression of P120 catenin in cholangiocarcinoma correlated with tumor clinicopathologic parameters. World J Gastroenterol. 2008;14:3739-44 pubmed
    ..An immunohistochemical study of E-cadherin and P120 catenin was performed on 42 specimens of ICC with a Dako Envision kit...
  49. Yanagisawa M, Huveldt D, Kreinest P, Lohse C, Cheville J, Parker A, et al. A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic disease. J Biol Chem. 2008;283:18344-54 pubmed publisher
    b>p120 catenin is a cadherin-associated protein that regulates Rho GTPases and promotes the invasiveness of E-cadherin-deficient cancer cells...
  50. Boguslavsky S, Grosheva I, Landau E, Shtutman M, Cohen M, Arnold K, et al. p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin. Proc Natl Acad Sci U S A. 2007;104:10882-7 pubmed
    The armadillo-family protein, p120 catenin (p120), binds to the juxtamembrane domain of classical cadherins and increases cell-cell junction stability...
  51. Xia X, Carnahan R, Vaughan M, Wildenberg G, Reynolds A. p120 serine and threonine phosphorylation is controlled by multiple ligand-receptor pathways but not cadherin ligation. Exp Cell Res. 2006;312:3336-48 pubmed
    b>p120-catenin (p120) regulates cadherin turnover and is required for cadherin stability...
  52. Chen Y, Chen C, Tung P, Huang S, Wang S. An acidic extracellular pH disrupts adherens junctions in HepG2 cells by Src kinases-dependent modification of E-cadherin. J Cell Biochem. 2009;108:851-9 pubmed publisher
    ..pH 6.6 treatment activated c-Src and Fyn kinase and induced tyrosine phosphorylation of p120 catenin (p120ctn) and E-cadherin. Inhibition of Src family kinases by PP2 attenuated the pH 6...
  53. Thoreson M, Reynolds A. Altered expression of the catenin p120 in human cancer: implications for tumor progression. Differentiation. 2002;70:583-9 pubmed
    ..Here, we focus on p120-catenin and its rising incidence in the pathology literature as a molecule altered in human tumors...
  54. Xiao K, Garner J, Buckley K, Vincent P, Chiasson C, Dejana E, et al. p120-Catenin regulates clathrin-dependent endocytosis of VE-cadherin. Mol Biol Cell. 2005;16:5141-51 pubmed
    ..VE-cadherin expression levels are regulated by p120 catenin, which prevents lysosomal degradation of cadherins by unknown mechanisms...
  55. Keirsebilck A, Bonne S, Staes K, van Hengel J, Nollet F, Reynolds A, et al. Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms. Genomics. 1998;50:129-46 pubmed
    ..these junctional plaque proteins are several members of the Armadillo gene family: beta-catenin, plakoglobin, and p120ctn. Recently it became clear that some catenins also mediate nuclear signaling...
  56. Aho S, Rothenberger K, Uitto J. Human p120ctn catenin: tissue-specific expression of isoforms and molecular interactions with BP180/type XVII collagen. J Cell Biochem. 1999;73:390-9 pubmed
    ..b>p120ctn is a catenin expressed in different isoforms due to alternative splicing and multiple translation start sites...
  57. Mariner D, Anastasiadis P, Keilhack H, Bohmer F, Wang J, Reynolds A. Identification of Src phosphorylation sites in the catenin p120ctn. J Biol Chem. 2001;276:28006-13 pubmed
    b>p120-catenin (p120(ctn)) interacts with the cytoplasmic tail of cadherins and is thought to regulate cadherin clustering during formation of adherens junctions...
  58. Ferber A, Yaen C, Sarmiento E, Martinez J. An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation. Exp Cell Res. 2002;274:35-44 pubmed
    ..Finally, our results for the first time demonstrate that the interaction of VE-cadherin with p120 catenin plays an important role in cellular growth, suggesting that the binding of p120 catenin to cadherins may ..
  59. Lu Q, Dobbs L, Gregory C, Lanford G, Revelo M, Shappell S, et al. Increased expression of delta-catenin/neural plakophilin-related armadillo protein is associated with the down-regulation and redistribution of E-cadherin and p120ctn in human prostate cancer. Hum Pathol. 2005;36:1037-48 pubmed
    ..delta-catenin immunoreactivity was accompanied by the down-regulation and redistribution of E-cadherin and p120ctn, major cell junction proteins whose inactivation is frequently associated with cancer progression...
  60. Brown M, Burnett P, Denning M, Reynolds A. PDGF receptor activation induces p120-catenin phosphorylation at serine 879 via a PKCalpha-dependent pathway. Exp Cell Res. 2009;315:39-49 pubmed publisher
    b>p120-catenin (p120) is required for cadherin stability and is thought to have a central role in modulating cell-cell adhesion...
  61. Liu Y, Wang Y, Zhang Y, Miao Y, Zhao Y, Zhang P, et al. Abnormal expression of p120-catenin, E-cadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer. Lung Cancer. 2009;63:375-82 pubmed publisher
    Studies on a variety of cell lines have shown that p120-catenin can directly regulate the stability of E-cadherin complexes and control the activity of small GTPases to influence cell adhesion...
  62. Stairs D, Bayne L, Rhoades B, Vega M, Waldron T, Kalabis J, et al. Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene. Cancer Cell. 2011;19:470-83 pubmed publisher
    p120-catenin (p120ctn) interacts with E-cadherin, but to our knowledge, no formal proof that p120ctn functions as a bona fide tumor suppressor gene has emerged to date...
  63. Baki L, Marambaud P, Efthimiopoulos S, Georgakopoulos A, Wen P, Cui W, et al. Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex. Proc Natl Acad Sci U S A. 2001;98:2381-6 pubmed
    ..This sequence is also required for E-cadherin binding of protein p120, a known regulator of cadherin-mediated cell adhesion...
  64. Wang M, Li N, Li J, Ma Y, Li D, Qin L, et al. Involvement of p120 in LPS-induced NF-kappaB activation and IL-8 production in human bronchial epithelial cells. Toxicol Lett. 2010;195:75-81 pubmed publisher
    b>P120-catenin (p120), a prototypic member of a subfamily of Armadillo repeat domain (Arm domain) proteins, not only participates in cell-cell adhesion, but also mediates inflammatory responses in the skin...
  65. Liu Y, Dong Q, Zhao Y, Dong X, Miao Y, Dai S, et al. P120-catenin isoforms 1A and 3A differently affect invasion and proliferation of lung cancer cells. Exp Cell Res. 2009;315:890-8 pubmed publisher
    Different isoforms of p120-catenin (p120ctn), a member of the Armadillo gene family, are variably expressed in different tissues as a result of alternative splicing and the use of multiple translation initiation codons...