Gene Symbol: p110
Description: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Alias: CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha, PI3-kinase p110 subunit alpha, PI3K-alpha, phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha, phosphatidylinositol 3-kinase, catalytic, alpha polypeptide, phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform, phosphoinositide-3-kinase, catalytic, alpha polypeptide, ptdIns-3-kinase subunit p110-alpha, serine/threonine protein kinase PIK3CA
Species: human

Top Publications

  1. doi Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis
    Wendy De Roock
    Centre for Human Genetics, KU Leuven, Leuven, Belgium
    Lancet Oncol 11:753-62. 2010
  2. pmc An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer
    Katherine Stemke-Hale
    Department of Systems Biology, The University of Texas MD Anderson Cancer, Houston, Texas 77030, USA
    Cancer Res 68:6084-91. 2008
  3. pmc Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
    Jeffrey A Engelman
    Nat Med 14:1351-6. 2008
  4. ncbi High frequency of mutations of the PIK3CA gene in human cancers
    Yardena Samuels
    Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
    Science 304:554. 2004
  5. ncbi The PIK3CA gene is mutated with high frequency in human breast cancers
    Kurtis E Bachman
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Department of Oncology, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 3:772-5. 2004
  6. pmc Class I PI3K in oncogenic cellular transformation
    L Zhao
    Division of Oncovirology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Oncogene 27:5486-96. 2008
  7. ncbi Phosphatidylinositol-3-OH kinase or RAS pathway mutations in human breast cancer cell lines
    Antoinette Hollestelle
    Department of Medical Oncology, Josephine Nefkens Institute Be414, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Mol Cancer Res 5:195-201. 2007
  8. doi Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab
    Jolien Tol
    Department of Medical Oncology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur J Cancer 46:1997-2009. 2010
  9. ncbi PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma
    Lao H Saal
    Integrated Program in Cellular, Molecular, and Biophysical Studies, Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cancer Res 65:2554-9. 2005
  10. ncbi Mutation of the PIK3CA gene in ovarian and breast cancer
    Ian G Campbell
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Cancer Res 64:7678-81. 2004

Detail Information

Publications316 found, 100 shown here

  1. doi Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis
    Wendy De Roock
    Centre for Human Genetics, KU Leuven, Leuven, Belgium
    Lancet Oncol 11:753-62. 2010
  2. pmc An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer
    Katherine Stemke-Hale
    Department of Systems Biology, The University of Texas MD Anderson Cancer, Houston, Texas 77030, USA
    Cancer Res 68:6084-91. 2008
    Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in cancer...
  3. pmc Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
    Jeffrey A Engelman
    Nat Med 14:1351-6. 2008
    Somatic mutations that activate phosphoinositide 3-kinase (PI3K) have been identified in the p110-alpha catalytic subunit (encoded by PIK3CA)...
  4. ncbi High frequency of mutations of the PIK3CA gene in human cancers
    Yardena Samuels
    Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
    Science 304:554. 2004
  5. ncbi The PIK3CA gene is mutated with high frequency in human breast cancers
    Kurtis E Bachman
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Department of Oncology, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 3:772-5. 2004
    ..It has recently been reported that somatic mutations within the PI3K subunit p110alpha (PIK3CA) are present in human colorectal and other cancers...
  6. pmc Class I PI3K in oncogenic cellular transformation
    L Zhao
    Division of Oncovirology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Oncogene 27:5486-96. 2008
    ..The catalytic subunit occurs in four isoforms designated as p110 alpha, p110 beta, p110 gamma and p110 delta...
  7. ncbi Phosphatidylinositol-3-OH kinase or RAS pathway mutations in human breast cancer cell lines
    Antoinette Hollestelle
    Department of Medical Oncology, Josephine Nefkens Institute Be414, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Mol Cancer Res 5:195-201. 2007
    Constitutive activation of the phosphatidylinositol-3-OH kinase (PI3K) and RAS signaling pathways are important events in tumor formation...
  8. doi Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab
    Jolien Tol
    Department of Medical Oncology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur J Cancer 46:1997-2009. 2010
    ..Here we assess the predictive value of other potential relevant markers involved in the epidermal growth factor receptor (EGFR) signalling pathways for response to cetuximab-based treatment...
  9. ncbi PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma
    Lao H Saal
    Integrated Program in Cellular, Molecular, and Biophysical Studies, Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cancer Res 65:2554-9. 2005
    Deregulation of the phosphatidylinositol 3-kinase (PI3K) pathway either through loss of PTEN or mutation of the catalytic subunit alpha of PI3K (PIK3CA) occurs frequently in human cancer...
  10. ncbi Mutation of the PIK3CA gene in ovarian and breast cancer
    Ian G Campbell
    VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Cancer Res 64:7678-81. 2004
    ..5% of all ovarian cancers and 45% of the endometrioid and clear cell subtypes. Our study is the first direct evidence that PIK3CA is an oncogene in ovarian cancer and greatly extends recent findings in breast cancer...
  11. doi Phosphoinositide 3-kinase (PI3K) pathway alterations are associated with histologic subtypes and are predictive of sensitivity to PI3K inhibitors in lung cancer preclinical models
    Jill M Spoerke
    Departments of Oncology Biomarker Development, Genentech Inc, South San Francisco, California 94080, USA
    Clin Cancer Res 18:6771-83. 2012
    Class 1 phosphatidylinositol 3-kinase (PI3K) plays a major role in cell proliferation and survival in a wide variety of human cancers...
  12. pmc PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches
    Giovanni Ligresti
    Department of Biomedical Sciences, University of Catania, Catania, Italy
    Cell Cycle 8:1352-8. 2009
    ..The PI3K pathway is considered to play an important role in tumorigenesis...
  13. ncbi PIK3CA mutation and amplification in human lung cancer
    Koji Okudela
    Department of Pathology I, Hamamatsu Universit School of Medicine, Hamamatsu, Japan
    Pathol Int 57:664-71. 2007
    ..The present demonstrates an important role of PIK3CA in human lung carcinogenesis...
  14. doi Transforming growth factor-β1 induces epithelial-to-mesenchymal transition in human lung cancer cells via PI3K/Akt and MEK/Erk1/2 signaling pathways
    Xiao Feng Chen
    Department of Thoracic Surgury, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China
    Mol Biol Rep 39:3549-56. 2012
    ..In this study, we performed a study to investigate whether PI3K/Akt and MAPK/Erk1/2 signaling pathways involved in EMT in the human lung cancer A549 cells...
  15. ncbi PIK3CA mutation status in Japanese lung cancer patients
    Osamu Kawano
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Lung Cancer 54:209-15. 2006
    ..PIK3CA gene mutations were rare in lung cancer; rarer in adenocarcinoma. Further functional analyses of the PIK3CA mutations are warranted to study if they could be the target of therapy for the lung cancer...
  16. ncbi High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma
    Katsutoshi Oda
    Cancer Research Institute, University of California San Francisco, San Francisco, California 94115, USA
    Cancer Res 65:10669-73. 2005
    The phosphatidylinositol 3'-kinase (PI3K) pathway is activated in many human cancers...
  17. pmc The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells
    Jean J Zhao
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:18443-8. 2005
    ..Mutations in the PIK3CB gene encoding p110beta, the only other widely expressed Class IA PI3K, have not been reported...
  18. ncbi The prevalence of PIK3CA mutations in gastric and colon cancer
    Sergia Velho
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Portugal
    Eur J Cancer 41:1649-54. 2005
    A wide variety of tumours show PIK3CA mutations leading to increased phosphatidylinositol-3 kinase (PI3K) activity...
  19. ncbi Functional analysis of PIK3CA gene mutations in human colorectal cancer
    Tsuneo Ikenoue
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo Hospital, Bunkyo ku, Japan
    Cancer Res 65:4562-7. 2005
    Mutations in the PIK3CA gene, which encodes the p110alpha catalytic subunit of phosphatidylinositol 3-kinase (PI3K), have been reported in human cancers, including colorectal cancer...
  20. pmc Phosphatidylinositol-3-kinase as a therapeutic target in melanoma
    Saadia A Aziz
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA
    Clin Cancer Res 15:3029-36. 2009
    Phosphatidylinositol-3 kinases (PI3K) are critical for malignant cellular processes including growth, proliferation, and survival, and are targets of drugs in clinical development...
  21. doi Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors
    Dominique S Meyer
    Friedrich Miescher Institute for Biomedical Research, Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Basel, Switzerland
    Cancer Res 71:4344-51. 2011
    The phosphoinositide 3-kinase (PI3K) signaling cascade, a key mediator of cellular survival, growth, and metabolism, is frequently altered in human cancer...
  22. doi Association between gain-of-function mutations in PIK3CA and resistance to HER2-targeted agents in HER2-amplified breast cancer cell lines
    Y Kataoka
    Hospital Pharmacy, National Cancer Hospital East, Kashiwa, Japan
    Ann Oncol 21:255-62. 2010
    ..We investigated the influence of PIK3CA mutations on sensitivity to HER2-targeted agents in naturally derived breast cancer cells...
  23. ncbi Uncommon mutation, but common amplifications, of the PIK3CA gene in thyroid tumors
    Guojun Wu
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 90:4688-93. 2005
    As in many other human cancers, overactivation of the phosphotidylinositol 3-kinase (PI3K)/Akt signaling pathway occurs frequently in thyroid cancer, but the mechanism is not completely clear.
  24. pmc PIK3CA mutations and copy number gains in human lung cancers
    Hiromasa Yamamoto
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390 8593, USA
    Cancer Res 68:6913-21. 2008
    ..PIK3CA mutations or gains are present in a subset of lung cancers and are of functional importance...
  25. pmc PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney St, Room JF 215C, Boston, MA 02115 USA
    J Clin Oncol 27:1477-84. 2009
    ..PIK3CA mutation and subsequent activation of the AKT pathway play an important role in colorectal carcinogenesis. However, little is known about the prognostic role of PIK3CA mutation in colon cancer...
  26. pmc PIK3CA mutation impact on survival in breast cancer patients and in ERα, PR and ERBB2-based subgroups
    Magdalena Cizkova
    Laboratoire d oncogénétique, Institut Curie, Hôpital René Huguenin, 35 rue Dailly, Saint Cloud, F 92210, France
    Breast Cancer Res 14:R28. 2012
    ..PIK3CA is the oncogene showing the highest frequency of gain-of-function mutations in breast cancer, but the prognostic value of PIK3CA mutation status is controversial...
  27. pmc Oncogenic mutations of PIK3CA in human cancers
    Yardena Samuels
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Curr Top Microbiol Immunol 347:21-41. 2010
    The involvement of the PIK3CA gene product p110α, the catalytic subunit of phosphatidylinositol 3-kinase (PI3K), in human cancer has been suggested for over 15 years, and support for this proposal had been provided by both genetic and ..
  28. doi PIK3CA in breast carcinoma: a mutational analysis of sporadic and hereditary cases
    Angela Michelucci
    Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, University Hospital of Pisa, Italy
    Diagn Mol Pathol 18:200-5. 2009
    The PI3K-Akt cascade is a key signaling pathway involved in cell proliferation, survival, and growth. Activating PIK3CA mutations have been reported in breast carcinoma (BC)...
  29. ncbi Mutation of the PIK3CA gene in anaplastic thyroid cancer
    Ginesa Garcia-Rostan
    Institute of Molecular Pathology and Immunology of Porto University, Porto, Portugal
    Cancer Res 65:10199-207. 2005
    The phosphatidylinositol 3'-kinase (PI3K) pathway is frequently activated in thyroid carcinomas through the constitutive activation of stimulatory molecules (e.g...
  30. doi PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation
    Katsutoshi Oda
    Cancer Research Institute, Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California, USA
    Cancer Res 68:8127-36. 2008
    ..cancers that possess mutations in PIK3CA, the catalytic subunit p110alpha of phosphatidylinositol 3'-kinase (PI3K), also possess mutations or alterations in genes upstream of PI3K such as Ras, ERBB2/ERBB3, or PTEN...
  31. ncbi Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in a Middle Eastern population
    Jehad Abubaker
    Department of Human Cancer Genomic Research, King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Cancer, MBC 98 16, P O Box 3354, Riyadh 11211, Saudi Arabia
    J Clin Endocrinol Metab 93:611-8. 2008
    Genetic aberration in phosphatidylinositol 3-kinase (PI3K)/AKT pathway has been detected in numerous and diverse human cancers...
  32. pmc Rare cancer-specific mutations in PIK3CA show gain of function
    Marco Gymnopoulos
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:5569-74. 2007
    ..mutants of PIK3CA, the gene coding for the catalytic subunit p110alpha of phosphatidylinositol 3-kinase (PI3K), were examined for their biological and biochemical properties...
  33. pmc High-throughput genotyping in metastatic esophageal squamous cell carcinoma identifies phosphoinositide-3-kinase and BRAF mutations
    Chi Hoon Maeng
    Division of Hematology Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    PLoS ONE 7:e41655. 2012
  34. doi Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor
    Sauveur Michel Maira
    Novartis Institute for Biomedical Research, Oncology Disease Area, Novartis Pharma AG, Klybeckstrasse 141, CH 4002 Basel, Switzerland
    Mol Cancer Ther 11:317-28. 2012
    Following the discovery of NVP-BEZ235, our first dual pan-PI3K/mTOR clinical compound, we sought to identify additional phosphoinositide 3-kinase (PI3K) inhibitors from different chemical classes with a different selectivity profile...
  35. doi KRAS, BRAF and PIK3CA mutations in human colorectal cancer: relationship with metastatic colorectal cancer
    Hong Tao Li
    State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 127 ChangLe West Road, Xi an, Shaanxi Province 710032, PR China
    Oncol Rep 25:1691-7. 2011
    ..Notably, our data indicated that colorectal cancers with KRAS and PIK3CA bi-mutations are more likely to develop into liver metastasis...
  36. pmc Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival
    Xiaoyun Liao
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 367:1596-606. 2012
    ..synthase 2 (PTGS2) (also known as cyclooxygenase-2) by aspirin down-regulates phosphatidylinositol 3-kinase (PI3K) signaling activity...
  37. pmc PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer
    Sherene Loi
    Department of Research, Molecular Oncology Laboratory, Peter MacCallum Cancer Centre, East Melbourne 3002, Australia
    Proc Natl Acad Sci U S A 107:10208-13. 2010
    ..transformation, and hence these lesions have been hypothesized to render tumors highly sensitive to therapeutic PI3K/mTOR inhibition...
  38. pmc Knockin of mutant PIK3CA activates multiple oncogenic pathways
    John P Gustin
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 106:2835-40. 2009
    ..Our findings suggest GSK3beta is an important effector of mutant PIK3CA, and that lithium, an FDA-approved therapy for bipolar disorders, has selective antineoplastic properties against cancers that harbor these mutations...
  39. ncbi PIK3CA mutations in breast cancer are associated with poor outcome
    Shao Ying Li
    School of Surgery and Pathology, University of Western Australia, Nedlands, Australia
    Breast Cancer Res Treat 96:91-5. 2006
    The phosphatidylinositol-3-kinase (PI3K)-AKT signaling pathway is considered to play an important role in tumorigenesis. Frequent somatic mutations in the PI3K subunit p110alpha (PIK3CA) occur in a variety of cancer types...
  40. ncbi PIK3CA gene amplification in Japanese non-small cell lung cancer
    Osamu Kawano
    Lung Cancer 58:159-60. 2007
    ..Among 11 patients with PIK3CA amplification, two patients harbored a PIK3CA mutation. There was significant difference in survival between the patients with PIK3CA normal copy number and the patients with PIK3CA amplification...
  41. pmc HIV-1 Tat promotes Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K/PTEN/AKT/GSK-3β signaling pathway
    Feng Zhou
    State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, People s Republic of China
    PLoS ONE 8:e53145. 2013
    ..Mechanistic studies indicated Tat activates PI3K and AKT, and inactivates PTEN and GSK-3β in vIL-6 expressing cells...
  42. pmc PI3K expression and PIK3CA mutations are related to colorectal cancer metastases
    Yu Fen Zhu
    Department of Oncology, Shanghai Xuhui District Center Hospital, Shanghai 200031, China
    World J Gastroenterol 18:3745-51. 2012
    To assess the significance of phosphatidylinositol 3-kinase (PI3K) in colorectal cancer (CRC) and toxicity of LY294002 in CRC cells with different metastatic abilities.
  43. doi Somatic mutation analysis of EGFR, KRAS, BRAF and PIK3CA in 861 patients with non-small cell lung cancer
    Jianping Xu
    Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China
    Cancer Biomark 10:63-9. 2011
    ..001), and higher in smokers compared to non-smokers (p< 0.001). The PIK3CA mutation rate was lower in adenocarcinomas compared to other forms of lung cancers (p=0.003)...
  44. pmc Somatic mutation and gain of copy number of PIK3CA in human breast cancer
    Guojun Wu
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Breast Cancer Res 7:R609-16. 2005
    ..Even though PIK3CA amplification and somatic mutation have been reported previously in various kinds of human cancers, the genetic change in PIK3CA in human breast cancer has not been clearly identified...
  45. doi Stromal cell-derived factor-1 (SDF-1) enhances cells invasion by αvβ6 integrin-mediated signaling in ovarian cancer
    Baoyao Xue
    Department of Obstetrics and Gynecology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    Mol Cell Biochem 380:177-84. 2013
    ..Consequently, our findings will provide a new explanation about how SDF-1 aggravates the pathogenesis of ovarian cancer...
  46. ncbi Mutations of the PIK3CA gene in hereditary colorectal cancers
    Michiko Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
    Int J Cancer 121:1627-30. 2007
    ..Our data suggest that PIK3CA mutations contribute to the invasion step from intramucosal carcinoma to invasive carcinoma in colorectal carcinogenesis in FAP and HNPCC patients at a similar extent to that seen in sporadic patients...
  47. pmc Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo
    Lazaros C Foukas
    Department of Biochemistry and Molecular Biology, University College London, London WC1E 6BT, United Kingdom
    Mol Cell Biol 24:966-75. 2004
    ..Here we investigate whether this phosphorylation can occur in vivo. We find that p110 alpha phosphorylates p85 alpha Ser608 in vivo with significant stoichiometry...
  48. ncbi HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway
    Anastassia D Blagoveshchenskaya
    Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Cell 111:853-66. 2002
    ..Here, we show that Nef and PACS-1 combine to usurp the ARF6 endocytic pathway by a PI3K-dependent process and downregulate cell surface MHC-I to the TGN...
  49. pmc Somatic mosaic activating mutations in PIK3CA cause CLOVES syndrome
    Kyle C Kurek
    Department of Pathology, Boston Children s Hospital, MA 02115, USA
    Am J Hum Genet 90:1108-15. 2012
    ..We conclude that CLOVES is caused by postzygotic activating mutations in PIK3CA. The application of similar sequencing strategies will probably identify additional genetic causes for sporadically occurring, nonheritable malformations...
  50. doi PIK3CA amplification is predictive of poor prognosis in Tunisian patients with nasopharyngeal carcinoma
    Ali Fendri
    Laboratory of Cancer Genetic and Production of Recombinant Proteins, Route Sidi, Mansour Sfax, Sfax, Tunisia
    Cancer Sci 100:2034-9. 2009
    ..02). We concluded that PIK3CA gene amplification is frequent in NPC and occurs in the advanced stage of NPC. Moreover, our finding emphasizes the association of PIK3CA gene amplification with worse prognosis in nasopharyngeal carcinoma...
  51. pmc De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly
    Jeong Ho Lee
    Institute for Genomic Medicine, Rady Children s Hospital, University of California, San Diego, La Jolla, California, USA
    Nat Genet 44:941-5. 2012
    ..Thus HME is probably a genetically mosaic disease caused by gain of function in phosphatidylinositol 3-kinase (PI3K)-AKT3-mTOR signaling.
  52. doi Androgen receptor levels and association with PIK3CA mutations and prognosis in breast cancer
    Ana M Gonzalez-Angulo
    Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 15:2472-8. 2009
    ..To examine the androgen receptor (AR) levels in breast cancer and to assess the impact of AR expression on patient outcomes...
  53. doi Frequent mutations and amplifications of the PIK3CA gene in pituitary tumors
    Yong Lin
    Department of Laboratory Medicine, Shanghai Medical College, Fudan University, Shanghai 200040, People s Republic of China
    Endocr Relat Cancer 16:301-10. 2009
    Genetic alterations in the PIK3CA gene of the phosphoinositide 3-kinase (PI3K)/AKT pathway have been found in many human tumors, but they have not been explored in pituitary tumors...
  54. doi Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors
    Kyle A Edgar
    Cancer Signaling and Translational Oncology, Genentech, Inc, South San Francisco, California 94080, USA
    Cancer Res 70:1164-72. 2010
    Therapeutic inhibitors are being developed against the phosphoinositide 3-kinase (PI3K) pathway, the deregulation of which drives tumor growth and survival in many cancers. There are eight PI3Ks in mammals divided into three classes...
  55. doi PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis
    C Mao
    Division of Epidemiology, Chinese University of Hong Kong, Hong Kong
    Ann Oncol 23:1518-25. 2012
  56. pmc Up-regulation of PIK3CA promotes metastasis in gastric carcinoma
    Ji Fang Liu
    Institute of Cancer Research, Affiliated Tumor Hospital of Guangzhou Medical College, Guangzhou 510095, Guangdong Province, China
    World J Gastroenterol 16:4986-91. 2010
    To explore expressions of PIK3CA in the progression of gastric cancer from primary to metastasis and its effects on activation of phosphatidylinositol 3-kinase (PI3K)/Akt pathway.
  57. pmc Hyaluronic acid and thrombin upregulate MT1-MMP through PI3K and Rac-1 signaling and prime the homing-related responses of cord blood hematopoietic stem/progenitor cells
    Neeta Shirvaikar
    Canadian Blood Services R and D, Edmonton, Canada
    Stem Cells Dev 20:19-30. 2011
  58. pmc A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomas
    Meghan L Rudd
    Cancer Genetics Branch, National Human Genome Research Institute, National Cancer Institute, Bethesda, Maryland, USA
    Clin Cancer Res 17:1331-40. 2011
    ..The goal of this study was to comprehensively define the incidence of mutations in all exons of PIK3CA in both endometrioid endometrial cancer (EEC) and nonendometrioid endometrial cancer (NEEC)...
  59. doi PIK3CA mutations, PTEN, and pHER2 expression and impact on outcome in HER2-positive early-stage breast cancer patients treated with adjuvant chemotherapy and trastuzumab
    J D Jensen
    Department of Oncology, Odense University Hospital, and Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
    Ann Oncol 23:2034-42. 2012
  60. doi PIK3CA mutation is associated with a favorable prognosis among patients with curatively resected esophageal squamous cell carcinoma
    Hironobu Shigaki
    Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan
    Clin Cancer Res 19:2451-9. 2013
    PIK3CA encodes the catalytic subunit of PI3K, p110α. Mutant PIK3CA stimulates the AKT pathway and promotes cancer cell proliferation. PIK3CA mutations have been associated with poor prognosis in patients with colorectal or lung cancer...
  61. pmc PIK3CA mutations in intraductal papillary mucinous neoplasm/carcinoma of the pancreas
    Frank Schönleben
    Department of Otolaryngology Head and Neck Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Clin Cancer Res 12:3851-5. 2006
    ..The mutational status of PIK3CA in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) has not been evaluated previously...
  62. ncbi HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells
    Maria Chiara Deregibus
    Cattedra di Nefrologia, Dipartimento di Medicina Interna Università di Torino, Centro Ricerca Medicina Sperimentale CeRMS, Italy
    J Biol Chem 277:25195-202. 2002
  63. pmc Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha
    Chuan Hsiang Huang
    Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cell Cycle 7:1151-6. 2008
    Phosphatidylinositide-3-kinases (PI3K) initiate a number of signaling pathways by recruiting other kinases, such as Akt, to the plasma membrane. One of the isoforms, PI3Kalpha, is an oncogene frequently mutated in several cancer types...
  64. ncbi Mutant PIK3CA promotes cell growth and invasion of human cancer cells
    Yardena Samuels
    The Sidney Kimmel Comprehensive Cancer Center and The Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
    Cancer Cell 7:561-73. 2005
    ..PIK3CA mutations resulted in attenuation of apoptosis and facilitated tumor invasion. Treatment with the PI3K inhibitor LY294002 abrogated PIK3CA signaling and preferentially inhibited growth of PIK3CA mutant cells...
  65. pmc PIK3CA alterations in Middle Eastern ovarian cancers
    Jehad Abubaker
    Department of Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Mol Cancer 8:51. 2009
    b>PI3K/AKTsignaling pathway plays an important role in cell growth, proliferation, and tumorgenesis of various malignancies. This signaling pathway has been shown to be frequently altered in several human cancers including ovarian cancers...
  66. pmc PIK3CA mutations in in situ and invasive breast carcinomas
    Alexander Miron
    Department of Cancer Biology, and Center for Cancer Genome Discovery, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 70:5674-8. 2010
  67. pmc Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha
    Minghao Sun
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:15547-52. 2010
    ..Studies with isoform-specific inhibitors of p110 suggest that expression of p85 mutants in fibroblasts leads exclusively to an activation of p110alpha, and ..
  68. pmc Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase
    Huan Pang
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 69:8868-76. 2009
    Class IA (p85/p110) phosphoinositide 3-kinases play a major role in regulating cell growth, survival, and motility...
  69. pmc Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern
    Christian Hafner
    Department of Dermatology, University of Regensburg, 93042 Regensburg, Germany
    Proc Natl Acad Sci U S A 104:13450-4. 2007
    Activating mutations of the p110 alpha subunit of PI3K (PIK3CA) oncogene have been identified in a broad spectrum of malignant tumors. However, their role in benign or preneoplastic conditions is unknown...
  70. doi Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer
    Fiona M Platt
    Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, United Kingdom
    Clin Cancer Res 15:6008-17. 2009
    The phosphatidylinositol 3-kinase (PI3K) pathway can be activated by alterations affecting several pathway components...
  71. pmc DNA sequence profiles of the colorectal cancer critical gene set KRAS-BRAF-PIK3CA-PTEN-TP53 related to age at disease onset
    Marianne Berg
    Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway
    PLoS ONE 5:e13978. 2010
  72. ncbi A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
    Katrien Berns
    Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Cancer Cell 12:395-402. 2007
    ..In a cohort of 55 breast cancer patients, activation of the PI3K pathway, as judged by the presence of oncogenic PIK3CA mutations or low PTEN expression, was associated with poor ..
  73. ncbi KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    Astrid Lievre
    Universite Paris Descartes, Institut National de la Sante et de la Recherche Medicale UMR 775, Paris, France
    Cancer Res 66:3992-5. 2006
    ..The EGFR amplification, which is not as frequent as initially reported, is also associated with response to this treatment...
  74. ncbi Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas
    Daniel K Broderick
    Brain Tumor Center, Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Res 64:5048-50. 2004
    ..These observations implicate PIK3CA as an oncogene in a wider spectrum of adult and pediatric brain tumors and suggest that PIK3CA may be a useful diagnostic marker or a therapeutic target in these cancers...
  75. pmc A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane
    Diana Mandelker
    The Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 106:16996-7001. 2009
    ..These structural and biochemical data suggest a previously undescribed mechanism for mutational activation of a kinase that involves perturbation of its interaction with the cellular membrane...
  76. pmc PI3Kα inhibitors that inhibit metastasis
    Oleg Schmidt-Kittler
    The Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Oncotarget 1:339-48. 2010
    Previous genetic analyses have suggested that mutations of the genes encoding PI3Kα facilitate invasion and metastasis but have less effect on primary tumor growth...
  77. ncbi PIK3CA gene mutations in pediatric and adult glioblastoma multiforme
    Gary L Gallia
    Department of Neurosurgery, Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB II, Room 257, Baltimore, MD 21231, USA
    Mol Cancer Res 4:709-14. 2006
    The phosphatidylinositol 3-kinases (PI3K) are a family of enzymes that relay important cellular growth control signals...
  78. ncbi PIK3CA mutation is predictive of poor survival in patients with colorectal cancer
    Shunsuke Kato
    Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Int J Cancer 121:1771-8. 2007
    The PI3K-AKT pathway is activated in a variety of human cancers, resulting in disturbance of cell growth, proliferation and survival...
  79. ncbi Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma
    Miina Ollikainen
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Int J Cancer 121:915-20. 2007
    While the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is known to be activated in multiple sporadic cancers, the role of this pathway in familial tumors is mostly unknown...
  80. ncbi Different prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomas
    Mattia Barbareschi
    Unit of Surgical Pathology, Laboratory of Molecular Pathology S Chiara Hospital, Trento, Italy, and Clinical Research Center, Center of Excellence on Aging, University Foundation, Chieti, Italy
    Clin Cancer Res 13:6064-9. 2007
    ..We decided to investigate the association of PIK3CA mutations with pathologic features and clinical outcome in a large series of patients with breast cancer...
  81. ncbi PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters
    Lluis Catasus
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Mod Pathol 21:131-9. 2008
  82. ncbi Induction of heme-oxygenase 1 requires the p38MAPK and PI3K pathways and suppresses apoptotic cell death following hypericin-mediated photodynamic therapy
    Silvia Kocanova
    Department Molecular and Cell Biology, Division of Biochemistry, Catholic University of Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Apoptosis 12:731-41. 2007
    ..We show that PDT engages the p38(MAPK) and PI3K signaling cascades for HO-1 induction...
  83. pmc The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex
    Ji Luo
    Department of Systems Biology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Cell Biol 170:455-64. 2005
    ..Surprisingly, monomeric p85 is preferentially localized to these foci compared with the p85-p110 dimer, and these foci are not sites of phosphatidylinositol-3,4,5-trisphosphate production...
  84. doi PIK3CA overexpression is a possible prognostic factor for favorable survival in ovarian clear cell carcinoma
    Azusa Abe
    Department of Obstetrics and Gynecology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki, 305 8575, Japan
    Hum Pathol 44:199-207. 2013
    ..PIK3CA may serve as a biomarker for good prognosis and a possible therapeutic target in this lethal subtype of ovarian cancer...
  85. ncbi Effect of advanced glycation end products on lectin-like oxidized low density lipoprotein receptor-1 expression in endothelial cells
    Sammy W M Shiu
    Department of Medicine, University of Hong Kong, Hong Kong
    J Atheroscler Thromb 19:1083-92. 2012
    ..Advanced glycation end products (AGEs) have been recently identified as other ligands to LOX-1 and shown to increase LOX-1 expressions in diabetes; therefore, we investigated the underlying mechanism involved...
  86. pmc Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC)
    Meiju Ji
    Department of Endocrinology, The First Affiliated Hospital of Xi an Jiaotong University College of Medicine, Xi an 710061, The People s Republic of China
    BMC Cancer 11:147. 2011
    ..However, the interaction between genetic and epigenetic events and their significance in lung tumorigenesis remains poorly understood...
  87. doi Characteristics and prevalence of KRAS, BRAF, and PIK3CA mutations in colorectal cancer by high-resolution melting analysis in Taiwanese population
    Li Ling Hsieh
    Division of Molecular Diagnostics, Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Clin Chim Acta 413:1605-11. 2012
    ..HRM analysis is a new gene scan tool that quickly performs the PCR and identifies sequence alterations without requiring post-PCR treatment...
  88. pmc Inhibition of constitutively activated phosphoinositide 3-kinase/AKT pathway enhances antitumor activity of chemotherapeutic agents in breast cancer susceptibility gene 1-defective breast cancer cells
    Yong Weon Yi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    Mol Carcinog 52:667-75. 2013
    ..We report here that the PI3K/AKT pathway is constitutively active in BRCA1-defective human breast cancer cells...
  89. pmc Coexistence of PIK3CA and other oncogene mutations in lung adenocarcinoma-rationale for comprehensive mutation profiling
    Jamie E Chaft
    Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, New York, USA
    Mol Cancer Ther 11:485-91. 2012
    Phosphoinositide-3-kinase catalytic alpha polypeptide (PIK3CA) encodes the p110α subunit of the mitogenic signaling protein phosphoinositide 3-kinase (PI3K)...
  90. pmc Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat
    Yuri Kim
    Department of Pharmacy, Kyung Hee University, Seoul, South Korea
    PLoS ONE 6:e21781. 2011
    The PI3K/Akt pathway regulates various stress-related cellular responses such as cell survival, cell proliferation, metabolism and protein synthesis...
  91. pmc PIK3CA mutations frequently coexist with RAS and BRAF mutations in patients with advanced cancers
    Filip Janku
    Department of Investigational Cancer Therapeutics Phase I Clinical Trials Program, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e22769. 2011
    Oncogenic mutations of PIK3CA, RAS (KRAS, NRAS), and BRAF have been identified in various malignancies, and activate the PI3K/AKT/mTOR and RAS/RAF/MEK pathways, respectively. Both pathways are critical drivers of tumorigenesis.
  92. doi A comprehensive immunohistochemical and molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene/mammalian target of rapamycin) pathway in bladder urothelial carcinoma
    Penelope Korkolopoulou
    First Department of Pathology, Laiko General Hospital, Athens, University School of Medicine, Athens, Greece
    BJU Int 110:E1237-48. 2012
    What's known on the subject? and What does the study add? A few published studies investigating single or various PI3K/AKT/mTOR signalling components have produced inconsistent results...
  93. doi MiR-1 targets PIK3CA and inhibits tumorigenic properties of A549 cells
    Qian Qian Yu
    Department of Oncology, First Affiliated Hospital of Nanjing Medical University, 300, Guangzhou Road, Nanjing, Jiangsu 210029, China
    Biomed Pharmacother 68:155-61. 2014
    ..mimics led to a significant reduction of phosphorylated Akt and survivin protein, the downstream targets of the PI3K/Akt pathway. Cell proliferation was studied using a cell counting kit...
  94. ncbi Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways
    ChuHee Lee
    Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Leukoc Biol 74:676-82. 2003
    ..Targeting these cellular signaling pathways may have benefit in controlling inflammatory sequelae of HIV infection such as in neurological disease...
  95. doi PIK3CA mutations and PTEN loss in salivary duct carcinomas
    Christopher C Griffith
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 37:1201-7. 2013
    ..and/or loss of the phosphatase and tensin homolog (PTEN) are known to activate the phosphoinositide 3-kinase (PI3K) pathway and may represent a therapeutic target. In 7 of 34 SDCs (20...
  96. pmc Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
    Sohye Kang
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:802-7. 2005
    ..The oncogenic transforming activity makes the mutated PI3-kinase proteins promising targets for small molecule inhibitors that could be developed into effective and highly specific anticancer drugs...
  97. pmc Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes
    Ankit Shah
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, Missouri, USA
    PLoS ONE 7:e52060. 2012
    ..clearly suggest that gp120 and MA affect IL-6 but not IL-8 in a synergistic manner and this synergy was mediated by PI3K/Akt and NF-κB pathways...
  98. ncbi HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes
    I W Park
    Division of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Blood 97:352-8. 2001
    ..These data indicate that the HIV-1 Tat protein may act as a protocytokine by causing the release of MCP-1 from the endothelial monolayer, and thereby facilitating monocyte transmigration into tissues via a PKC signaling pathway...
  99. pmc Human immunodeficiency virus type 1 Tat accelerates Kaposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice
    Xiuying Chen
    Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, PR China
    Neoplasia 11:1272-84. 2009
  100. pmc Two multiplex assays that simultaneously identify 22 possible mutation sites in the KRAS, BRAF, NRAS and PIK3CA genes
    Irene Lurkin
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 5:e8802. 2010
    ..In addition, these assays are cheaper and easier to interpret. The assays may also be of use for selection of patients with other tumor types...
  101. pmc HIV-1 Nef in macrophage-mediated disease pathogenesis
    Susanna L Lamers
    BioInfoExperts, Thibodaux, LA, USA
    Int Rev Immunol 31:432-50. 2012
    ..Moreover, genetic variation in Nef may also guide the macrophage response. Herein, we review findings relating to the Nef-macrophage interaction and how this relationship contributes to disease pathogenesis...

Research Grants105 found, 100 shown here

  1. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..Recently, special attention has focused on the role of phosphatidylinositol 3-kinase (PI3K) signaling pathways as mediator of leptin effects in hypothalamic neurons Therefore, we hypothesize that PI3K ..
  2. Peptide Therapy for Pulmonary Arterial Hypertension
    Jawaharlal M Patel; Fiscal Year: 2013
    ..with specific focus on Ca2+ release, activation of signaling modules [phospatidylinositide (PI) 3-kinase (PI3K), protein kinase B (PKB or Akt), protein kinase A (PKA), and Src tysorine kinase (SrcK)], phosphorylation of ..
  3. The p110 alpha and delta isoforms of PI3 kinase in hematopoiesis and leukemia
    Kira Gritsman; Fiscal Year: 2013
    ..In hematopoietic cells, receptor tyrosine kinases signal through the catalytic p110 subunit of PI3K, which has 3 isoforms (, , ), to activate the phosphorylation of the target kinase AKT...
  4. Signaling pathways regulated by GSK3 in hematopoietic stem cell
    Jian Huang; Fiscal Year: 2012
    ..Recently, the PTEN-PI3K-mTOR pathway has been demonstrated to play an essential role in HSC maintenance...
  5. TGF-beta-induced non-Smad signaling events and cancer cell behavior
    RIK M DERYNCK; Fiscal Year: 2013
    ..phosphorylation on Tyr in response to TGF-[unreadable] may provide the biochemical basis for activation of both the PI3K-Akt-TOR and the Shc-Erk MAPK pathways by TGF-[unreadable]...
    Ricardo Azziz; Fiscal Year: 2010
    ..70% of women with PCOS, which our data suggest may result from alterations in the phosphatidylinositol 3-kinase (PI3K)/Akt signaling cascade, downstream of the insulin receptor (IR)...
  7. Signaling pathways regulated by GSK3 in hematopoietic stem cell
    Jian Huang; Fiscal Year: 2013
    ..Recently, the PTEN-PI3K-mTOR pathway has been demonstrated to play an essential role in HSC maintenance...
  8. SGK1 is a Central Regulator of P. gingivalis-Induced Inflammation
    Huizhi Wang; Fiscal Year: 2013
    ..Whereas the PI3K-Akt-GSK3-[unreadable] pathway has been demonstrated to play a critical regulatory role in TLR-mediated inflammatory ..
  9. Regulation of Osteoclast Function : Role of the Cbl-PI3K Complex
    Archana Sanjay; Fiscal Year: 2012
    ..Abolishing the interaction between Cbl and PI3K kinase significantly compromises the bone resorbing capacity of osteoclasts both in vivo and in vitro, indicating ..
    Martina Buck; Fiscal Year: 2010
    ..In preliminary studies, we have also found that E2, in the absence of extracellular growth factors, increases PIP2, PI3K, PDK1 and Akt, as well as their activities. This signaling cascade promotes proliferation...
  11. Novel Immunotherapies for Lymphoid Malignancies
    Natarajan Muthusamy; Fiscal Year: 2013
    ..Consistent with this, inhibition of pro-survival signaling by PI3K and BTK overcame the inhibitory effects of the C-terminal domain resulting in enhanced TRU-016 induced apoptosis...
  12. Signaling Pathways in Renal Fibrogenesis
    H William Schnaper; Fiscal Year: 2013
    ..type I collagen expression through phosphorylation of linker-region serine and/or threonine residues of Smad3;and PI3K, which acts at several points along the pathway leading to ERK, is a promising target for blunting the collagen ..
  13. Beta-cell Proliferation
    Fredric E Wondisford; Fiscal Year: 2013
    ..to its receptor on [unreadable]-cells, GLP-1 stimulates both cyclic AMP (cAMP) and phosphoinositol 3 kinase (PI3K) activation. Both cAMP and PI3K signaling pathways are implicated in [unreadable]-cell proliferation...
  14. Regulation of SMG Development by Adhesion Receptors
    A Sue Menko; Fiscal Year: 2012
    ..junctions signal differentiation and protection from apoptotic death most likely through the activation of PI3K/Akt pathway...
  15. Targeting the ICOS/ICOSL pathway to improve anti-tumor immune responses
    Padmanee Sharma; Fiscal Year: 2013
    ..We now hypothesize that the ICOS/ICOSL pathway induces optimal T cell anti-tumor responses due to ICOS-mediated PI3K signaling...
  16. Role of Integrin-Linked Kinase in Heart Failure and Ischemic Injury
    Anthony Rosenzweig; Fiscal Year: 2010
    ..activation of Akt has deleterious effects associated with feedback inhibition of upstream IRS-1/PI 3-kinase (PI3K) signaling...
  17. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  18. Gq-coupled Receptors Inhibit PI 3-kinase/Akt Signaling Pathway
    Richard Z Lin; Fiscal Year: 2012
    The goal of this proposal is to understand the role of class IA phosphatidylinositol 3&#8208;kinase (PI3K) p110alpha and p110beta in regulating pathological and physiological cell growth in the pancreas and skeletal muscle...
  19. Chemokine Signals in the Premetastatic Niche Inhibit Metastasis
    Ann Richmond; Fiscal Year: 2013
    ..Moreover, current PI3K inhibitor therapies for breast cancer patients might fail if they reverse this entrainment, counteract the effect ..
  20. Determinants of Germinal Center B Cell Differentiation
    Robert C Rickert; Fiscal Year: 2013
    ..Herein we investigate the pivotal roles of SHIP and PTEN inositol phosphatases in regulating the PI3K pathway and its noted impact on late B cell maturation...
  21. Role of serum- and glucocorticoid-regulated kinase-1 in electrical remodeling
    Anthony Rosenzweig; Fiscal Year: 2013
    ..Serum- and glucocorticoid-regulated kinase-1 (SGK1) is a PI3-kinase (PI3K)-dependent kinase that is activated in pathological hypertrophy and heart failure (HF) but not in physiological ..
    Georges E Haddad; Fiscal Year: 2011
    ..The overall goal of the current proposal is to delineate the links between PI3K signaling and the preservation of cardiac function in the context of alcohol intake...
  23. Nuclear GTPase PIKE Regulation and Functions
    Keqiang Ye; Fiscal Year: 2013
    Abstract PIKE (PI 3-kinase Enhancer) is a brain specific GTPase that enhances PI 3-kinase (PI3K) activity. PIKE binds and stimulates PI3K activity in a GTP-dependent manner...
    BRIAN MICHAEL WICZER; Fiscal Year: 2011
    ..Class III phosphatidylinositol-3OH kinase (PI3K), a heterodimer consisting of the catalytic subunit, hVps34, and a regulatory subunit, hVps15, mediates the ..
  25. Targeting PTEN Null Tumors via Inhibition of the p110beta Isoform of PI3 Kinase
    Thomas M Roberts; Fiscal Year: 2010
    ..RTKs), G-protein coupled receptors (GPCRs) or Ras, class IA PI3Ks, consisting of three catalytic isoforms termed p110?, p110? and p110?, are activated to generate the primary intracellular lipid signal, phosphatidylinositol 3,4,5-..
  26. Mechanisms of protein-energy-wasting in chronic kidney disease
    Zhaoyong Hu; Fiscal Year: 2013
    ..Defects in the IGF-1/PI3K/p- Akt pathway stimulate caspase-3 activation and contribute to muscle wasting...
  27. mTOR Inhibition as a Therapeutic Strategy for Acute Myeloid Leukemia
    Alexander E Perl; Fiscal Year: 2013
    ..Inhibition of PI3K's downstream effector, mammalian target of rapamycin (mTOR), using the clinically available reagent rapamycin ..
  28. Neural Progenitor Genes and Brain Tumors
    Harley Ian Kornblum; Fiscal Year: 2013
    ..and gene manipulation strategy to determine the dependence of GBM stem cell-like cells on different nodes of the PI3K pathway...
  29. Regulation of Clathrin and Adaptor Function
    James H Keen; Fiscal Year: 2013
    ..found that through its VHS domain GGA1 binds specifically and directly to the class II PI-3-Kinase-C2[unreadable] (PI3K- C2[unreadable])...
    Patricia B Hoyer; Fiscal Year: 2010
    ..small pre-antral follicles by stimulation of primordial to small primary recruitment via interactions with the PI3K signaling pathway...
    Thomas M Roberts; Fiscal Year: 2013
    ..My colleagues and I have continued our studies of MT and PI3K, and have recently used conditional knockouts of the key catalytic subunits of PI3K, p110? and p110?, to discover a ..
  32. Molecular Targets in T Lineage Leukemia
    Monique Dail; Fiscal Year: 2012
    ..T-ALL patients frequently have genetic alterations that activate the Ras/PI3K/Akt pathway and Notch1, thus testing inhibitors of these pathways is a high priority...
  33. Obesity-Related Insulin Resistance Signaling Pathway Factors and Colon Cancer
    Li Li; Fiscal Year: 2013
    ..critical insulin and related growth factor signaling pathways: 1) phosphatidylinositol-3 Kinase/protein kinase B (PI3K/AKT) signaling cascade;2) AMP-activated protein kinase (AMPK) pathway;3) mitogen-activated protein (MAP) kinase ..
  34. Cellular Mechanisms of Renal Interstitial Fibrosis
    Jeffrey L Barnes; Fiscal Year: 2013
    ..Nox2 and Nox4 and phox subunits) will be examined in PDGFR-2 and TGF-2 receptor transduction of SMADs, Rho/ROCK, PI3K, and ERK1/2 regulation of activation of kidney myofibroblast...
  35. The Control of T Cell Development in Responses by PTEN
    Laurence A Turka; Fiscal Year: 2011
    ..g., TCR, CD28, and &#947;c cytokine receptors) signal via PI-3 kinase (PI3K). The tumor suppressor gene Pten is a lipid phosphatase which directly catalyzes the reverse of the PI3K reaction...
  36. Targeting the p110beta Isoform of PI3 Kinase in Pten Null Tumors
    Jean Zhao; Fiscal Year: 2013
    ..This pathway is frequently activated via mutation in both commonly occurring and rare tumor types. Current PI3K directed therapies are targeted to the catalytic subunits of the so-called Class I enzymes...
  37. Revealing new regulators of EGFR-P13K driven glioma proliferation and migration
    Renee D Read; Fiscal Year: 2013
    ..Constitutive activation of the EGFR-Ras and PI-3 kinase (PI3K) signaling pathways is a common feature in human GBM and is sufficient to cause glioblastoma-like phenotypes in ..
  38. Revealing new regulators of EGFR-P13K driven glioma proliferation and migration
    Renee D Read; Fiscal Year: 2010
    Constitutive activation of the EGFR-Ras and PI-3 kinase (PI3K) signaling pathways is a common feature in human GBM and is sufficient to cause glioblastoma-like phenotypes in mouse models...
  39. Combining Anti-Invasive and Anti-Angiogenic Therapies for the treatment of GBM
    ..The focus of this application is to rigorously examine the influence of SFK and PI3K signaling on the pro-invasive effects of bevacizumab both in primary GBM orthotopic xenograft models and in ..
  40. Positive Feedback Loops in Growth Cone Symmetry Breaking and Guidance Signaling
    Thomas R Cheever; Fiscal Year: 2013
    ..of the lipid signaling molecule phosphatidylinositol (PI) 3,4,5-triphosphate (PIP3), the lipid kinase PI-3 kinase (PI3K), the Rho GTPase Rac, and actin dynamics...
  41. P3IK Signaling and Biology of Therapeutic Response in Brain and Prostate Tumors
    Eric C Holland; Fiscal Year: 2013
    ..We will investigate the biology of therapeutic response in solid tumors with particular interest in the PI3-kinase (PI3K) pathway and cells that are resistant to standard of care treatments...
    Peter K Vogt; Fiscal Year: 2013
    ..The proposed work will use two basic approaches: (1) a genetic analysis of the oncogenic functions of p110[unreadable], the catalytic subunit of PI3K, and (2) genome-wide interrogations for novel regulators and targets of ..
    Beth Levine; Fiscal Year: 2009
    ..we anticipate that these studies will establish that beclin 1 functions as a tumor suppressor through its Class III-PI3K-dependent autophagy function, and that autophagy represents a fundamental mechanism involved in tumor suppression ..
  44. Targeting BRAF and MEK in tumors with BRAF and RAS mutations.
    David B Solit; Fiscal Year: 2012
    ..to MEK inhibition may be the result of additional genetic alterations in parallel signaling pathway such as the PI3K/AKT pathway. BRAF mutations commonly co-exist with PTEN loss in melanoma...
  45. Oncogenic role of PIK3CA hotspot mutations
    RAMON E PARSONS; Fiscal Year: 2013
    ..The PIK3CA gene (encoding the catalytic p110-alpha subunit of PI3-kinase) is one of the most frequently mutated oncogenes in human cancer...
  46. Role of PI3Kinase Gamma in Tumor Progression and Metastasis
    Judith A Varner; Fiscal Year: 2013
    ..myeloid cell trafficking during inflammation, tumor progression and metastasis, 2) to evaluate the role of PI3K? in the regulation of immunosuppression during tumor progression, and 3) to evaluate the potential of PI3- kinase ? ..
  47. PI 3-Kinase and Interplay with Other Signaling Pathways
    David L Woodland; Fiscal Year: 2013
    ..The PI3K-Akt-mTOR signaling pathway is one of the primary mechanisms for controlling tumor cell growth, survival, and ..
  48. Regulation of T Cell Activation and Development by PIK3IP1
    Lawrence P Kane; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Proper regulation of the PI-3 kinase (PI3k) pathway is critical for normal T cell development, activation and homeostasis...
  49. Determinants of Efficacy to the Akt Inhibitor Perifosine in Colorectal Cancer
    Cathy Eng; Fiscal Year: 2012
    ..and survival and may be abnormally or constitutively activated (overexpression and mutation), altered by PI3K (mutation), and/or loss of PTEN (mutation, loss of heterozygosity, or methylation)...
  50. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009
    ..In Specific Aim 2 we will examine the role of polyamines in cell cycle regulation and PI3K/Akt cell survival activation in NB cells...
  51. Derivation of Mature Oocytes from Human Primordial Follicles
    AARON JW HSUEH; Fiscal Year: 2010
    ..The PTEN gene encodes a phosphatase enzyme that negatively regulates the phosphoinositol 3-kinase (PI3K) and Akt signaling pathway...
  52. Molecular mechanisms of C/EBP alpha mediated growth arrest
    Nikolai A Timchenko; Fiscal Year: 2013
    ..proteins and these interactions are controlled by certain signal transduction pathways such as cyclin D3-cdk4/6 and PI3K-Akt-PP2A...
  53. Regulation of IGF-1 and Insulin Signaling by O-GlcNAc Glycosylation
    LAUREN ELIZABETH BALL; Fiscal Year: 2013
    ..Signaling through the IRS proteins to PI3K/Akt and/or the Grb2/ERK pathways is mediated and modulated by posttranslational regulation...
  54. N-3 Fatty Acid-Induced Akt Suppression: Chemoprevention for Pancreatic Neoplasia
    PAUL JOSEPH GRIPPO; Fiscal Year: 2013
    ..In vivo, this work will be done in mutant Kras expressing mouse pancreas void of EP2, PI3K, Cox-2, Akt, Foxo, or Bad...
  55. Role of Fox03a in Regulating the IPF Fibroblast Phenotype
    RICHARD S NHO; Fiscal Year: 2010
    ..type I collagen suppresses normal fibroblast proliferation via high PTEN activity which inhibits the major PI3K/Akt signaling pathway...
  56. Biophysical Regulation of Breast Differentiation
    Patricia J Keely; Fiscal Year: 2013
    ..Aim 3: Test the link between collagen density, FAK and downstream signaling events, ERK, Src, and PI3K, in regulating cell proliferation and invasion. FAK-/- cells lose activation of ERK and PI3K pathways...
  57. Elucidating the Role of Akt and Keratins in Autophagy and Tumorigenesis
    Richard C Wang; Fiscal Year: 2013
    ..Next, we will determine how the status of PI3K-Akt activation in cancer cells affects the phosphorylation of Beclin 1...
  58. Cancer-Associated, Interdependent Regulation of mTOR, AKT, and IKK/NF-kappaB
    ALBERT SIDNEY BALDWIN; Fiscal Year: 2013
    ..activated in a variety of cancers via (i) mutation in the PTEN tumor suppressor, (ii) activating mutations in PI3K, and (ii) through growth factor receptor upregulation/stimulation...
  59. Peripheral T Cell tolerance by targeting AKT
    Claudio Anasetti; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: AKT, a phosphatidylinositol 3-kinase (PI3K)-dependent serine-threonine kinase, promotes glucose metabolism and survival of activated T cells and limits ..
  60. MAP Kinase Signaling in Lymphoma: A Novel Therapeutic Paradigm
    Ronald B Gartenhaus; Fiscal Year: 2013
    ..e., NF8B inhibitor, dual PI3K/AKT inhibitor, mTOR inhibitor), will effectively repress the lymphoma phenotype pre-clinically in B-cell and T-cell ..
  61. Akt, cellular senescence, and lifespan
    Nissim Hay; Fiscal Year: 2010
    ..Genetics studies in nematodes and flies showed that impaired insulin signaling through PI3K and its downstream effector, the serine/threonine kinase, Akt, is associated with a decline in energy metabolism ..
  62. Akt-EphA2 Crosstalk in Glioma Invasion
    Bingcheng Wang; Fiscal Year: 2013
    ..Recent large scale genome studies show that PI3K/Akt signaling cascade is activated in 88% of GBM...
  63. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  64. Pulmonary Vascular-Right Ventricular Axis Research Program
    Wai Hong Wilson Tang; Fiscal Year: 2013
    ..AR numbers are low due to defective intracellular recycling of phosphorylated receptors. Consistent with PI3K inhibition of phosphatases, PAH PAEC and cardiomyocytes have high levels of the inactive pT495 eNOS, identifying ..
  65. Misty: a model for central regulation of bone remodeling
    CLIFFORD JAMES ROSEN; Fiscal Year: 2013
    ..kinase receptor that heterodimerizes with other ErbB receptors to enhance cell proliferation through the MAPK and PI3K pathways...
  66. ATF4 and Osteoclastogenesis
    Guozhi Xiao; Fiscal Year: 2013
    ..regulating osteoclastogenesis by two distinct mechanisms: 1) ATF4 modulates M-CSF induction of RANK expression via PI3K/AKT-dependent phosphorylation and protein stabilization and/or activation;2) ATF4 mediates RANKL induction of ..
  67. Mitochondrial Metabolism and ROS Regulate Lung Cancer
    Navdeep S Chandel; Fiscal Year: 2013
    ..ROS have been proposed to serve as signaling molecules to activate numerous signaling pathways, including PI3K, ERK1/2 MAPK, and the transcription factors hypoxia inducible factors (HIFs), which promote tumor cell ..
  68. Role of Angiogenic CXC Chemokines in Intramembranous Bone Repair
    Dean T Yamaguchi; Fiscal Year: 2013
    ..CXCR2 signaling involving signal transducer and activator of transcription-3 (STAT-3), phosphoinositide 3-kinase (PI3K), and MAPK will be assessed as above in addition to utilizing small molecule inhibitors of CXCR2...
  69. EphA2 kinase in prostate cancer
    Bingcheng Wang; Fiscal Year: 2013
    ..PTEN loss leads to activation of PI3K/Akt...
  70. PI3K/Akt-mediated PDGFRalpha signaling in craniofacial development
    KATHERINE ANN FANTAUZZO; Fiscal Year: 2013
    ..Previous work by the Soriano laboratory has identified PI3K as the main downstream effector of PDGFR[unreadable] signaling during craniofacial development in the mouse, ..
  71. Profilin-1 phosphorylation in neovascularization
    Yi Fan; Fiscal Year: 2013
    ..Interestingly, Pfn-1 phosphorylation is directly induced by VEGFR2/Src, independent of classic PI3K-mediated multistep signal cascades...
  72. Cell Cycle Regulation and Adult T Cell Leukemia
    Chou Zen Giam; Fiscal Year: 2013
    ..p21 are common in Tax-expressing HTLV-1-transformed T (HTxT) cells and most likely occur through activation of the PI3K- Akt pathway...
  73. Novel regulation of PI3K/Akt to direct targeted breast cancer therapies
    Wenyi Wei; Fiscal Year: 2013
    ..Instead, our studies will inform the use of Cdk2, Skp2 and Akt inhibitors for targeted therapy to achieve optimal treatment efficacy in the clinic. ..
  74. Role of Vimentin in Pathogenesis of CNS Inflammation
    Sheng He Huang; Fiscal Year: 2013
    ..g., caveolin-1, PI3K, ERK, CaM kinase II and Rac1) in lipid rafts...
  75. Examining the role of the Lissencephaly Protein, Lis1, in Dynein-Based Transport
    Deanna S Smith; Fiscal Year: 2013
    ..Notably, the dynein response to PPAR3 agonists requires PI3K activity and is mimicked by lithium, a potent Gsk32 inhibitor used to treat mood disorders...
  76. Exploring the Impact of Negative Energy Balance in Men with Prostate Cancer
    Wendy Demark-Wahnefried; Fiscal Year: 2013
    ..g., leptin, vascular endothelial growth factor (VEGF), phosphatidylinositol 3 kinase (PI3K), and the mammalian target of rapamycin (mTOR), and may ultimately affect tumor proliferation rate and apoptosis...
  77. Characterizing the mechanisms of PDGFRalpha regulation in upper lip development
    Fenglei He; Fiscal Year: 2013
    ..In the third specific aim, we will analyze the role of PDGFR[unreadable] engaged PI3K signaling in MNP and neural crest development using PDGFR[unreadable] signaling mutant PDGFR[unreadable] PI3K/PI3K ..
  78. Role of 12/15-lipoxygenase in mechanisms of muscle atrophy during aging
    Arunabh Bhattacharya; Fiscal Year: 2013
    ..Since induction of protein degradation pathways is modulated by PI3K/Akt signaling and downstream mTOR and FoxO3 pathways, and activation of NF-[unreadable]B, these pathways will be ..
  79. The Effect of Diet and Nutrients on the Progression and Treatment of Prostate Can
    George Thomas; Fiscal Year: 2013
    ..actually impinges on key intracellular signaling pathways, particularly the insulin-IGFI and nutrient- mediated PI3K/ mTORCI signaling pathway, which is opposed by a large number of tumor suppressors including PTEN, TSC1/2, NF1, ..
  80. Crosstalk between Desmogleins and Canonical Hedgehog Signaling
    Donna Brennan; Fiscal Year: 2013
    ..Key signaling molecules have been shown to be required for Gli activation including Gi proteins, PI3K and AKT;while PKA and GSK3[unreadable] promote partial Gli degradation...
  81. Ki-Ras Signaling in Pancreatic Cancer: Role of a Novel Akt Regulator
    Sushovan Guha; Fiscal Year: 2013
    ..The long-term goal is to elucidate the role and regulation of the phosphoinositide 3-kinase (PI3K) signaling pathway and its protein ki- nase mediator Akt in PDAC and develop more effective antagonists against ..
  82. Regulation of B Lymphocyte Defects in Senescent Humans
    Bonnie B Blomberg; Fiscal Year: 2013
    ..binding to the 3'untranslated region (UTR);c) establish mechanisms of TTP regulation including MAPK, ERK and PI3K pathways;and d) determine microRNA involvement in E47 mRNA stability and aged B cell functions...
  83. Short-form Ron Kinase in Tumor Progression and Metastasis
    Alana L Welm; Fiscal Year: 2013
    ..Mechanistic studies revealed an interaction between sfRon and PI3K that was required for sfRon function...
  84. Regulation of Intestinal Stem Cell Activation in Colitis
    Terrence A Barrett; Fiscal Year: 2013
    ..The present proposal makes use of a novel genetic model for reducing PI3K signaling in colonic intestinal epithelial cells (IEC) during colitis...
  85. Regulation of molecular thermal ablative resistance in hepatocellular carcinoma
    David A Woodrum; Fiscal Year: 2013
    ..We have identified a critical role for heat stress induced MET and EGFR receptor tyrosine kinase (RTK) mediated PI3K-AKT survival signaling in HCC thermal resistance and progression and are especially excited about the observation ..
  86. Perturbed cell signaling network and suicide neurobiology
    Yogesh Dwivedi; Fiscal Year: 2013
    ..via TrkB-mediated activation of extracellular signal-regulated kinase (ERK)1/2 and phosphoinositide 3 kinase (PI3K) signaling pathways...
  87. Zebrafish model of acute kidney injury
    Aleksandr Vasilyev; Fiscal Year: 2013
    ..We will also test the role of Pi3K signaling in mediating the proliferative response...
    NICOLAS GUILLERMO BAZAN; Fiscal Year: 2013
    ..aims: Specific Aim 1: To test the hypothesis that NPD1 induces RPE cell survival through upstream signaling by PI3K/Akt, and dephosphorylation of Bcl-xL by PP2A...
  89. C-reactive protein promotes myeloma cell-mediated bone destruction
    Qing Yi; Fiscal Year: 2013
    ..CRP binds activating Fc? receptors, activates PI3K/Akt, ERK, and NF-?B pathways and inhibits caspase cascade activation induced by chemotherapy drugs...
  90. Neurovascular Protection for Early Brain Injury after SAH
    John H Zhang; Fiscal Year: 2013
    ..Our specific hypothesis is that (1) rOPN performs anti-apoptotic signaling mediated by FAK signaling and (2) via PI3K/ Akt pathways. Aim 3 will determine the mechanism of blood brain barrier protection by rOPN after SAH...
  91. Role of Tyrosine Phosphorylation of TbRI
    KOY Y SAETEURN; Fiscal Year: 2013
    ..TGF-b also activates non-Smad pathways including the PI3K-Akt-mTOR and Erk- MAP kinase pathways, key signaling pathways that are induced by receptor tyrosine kinases and are ..
  92. Structural mutation analysis of PTEN and its possible genotype-phenotype correlat
    IRIS NIRA SMITH; Fiscal Year: 2013
    ..PIP3 activates a variety of downstream effectors that turn on the PI3K/Akt oncogenic pathway leading to unregulated cell proliferation and tumorigenesis...
  93. Asbestosis is regulated by Rac1-mediated mitochondrial H2O2 levels
    A Brent Carter; Fiscal Year: 2013
    ..The interaction of Rac1 signaling and the PI3K/Akt pathway may positively or negatively modulate each other...
  94. ZNF-Mediated Resistance to Imatinib Mesylate in Gastrointestinal Stromal Tumor
    Lori Rink; Fiscal Year: 2013
    ..Interestingly, hypoxia has been shown to upregulate expression of both NEDD9 and periostin (through the PI3K) leading to increased aggressiveness and enhanced survival of tumor cells...
  95. MSKCC Center for Molecular Imaging in Cancer
    STEVEN MARK LARSON; Fiscal Year: 2013
    ..and PET technology (Koutcher);RP3;pharmacologic dissection of the biology and clinical benefit of inhibiting the PI3K and Ras/ERK signal transduction pathways in melanoma and thyroid cancer (Rosen/Santos);RP4: genome wide RNA ..
  96. Characterization of Burn-Induced Hepatic Apoptosis
    Marc Gerhard Jeschke; Fiscal Year: 2013
    ..that these pathophysiological processes are related to hepatic inflammation, altered phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling, depletion of the hepatic calcium stores, the unfolded protein response (UPR), ..
  97. The Akt-associated microRNAs in cancer cells
    Yin Yuan Mo; Fiscal Year: 2013
    ..a better understanding of this Akt-microRNA regulatory network is critical to successful targeting of the PI3K/Akt pathway for cancer therapy. We propose three specific aims in this application...
  98. Stem cells in liver regeneration: fusion or plasticity
    Bryon E Petersen; Fiscal Year: 2013
    ..Specific aim 2: We hypothesize that activation of the MEK and PI3K signal transduction pathways following SDF-1 binding to CXCR4 receptor on the cell membrane enhances both ..
  99. Molecular mechanisms of resistance to HER2 inhibitors in breast cancer
    Brent N Rexer; Fiscal Year: 2013
    ..Aberrant activation of the phosphoinositide-3-kinase (PI3K)-Akt axis is emerging as an important mechanism of resistance to anti-HER2 therapies, supported by preliminary data ..
  100. Mechanism of Resistance to Arginine Deiminase Therapy in Advance Melanoma
    Macus T Kuo; Fiscal Year: 2013
    ..the regulatory mechanisms of AS expression: Our preliminary results suggest that phosphatidylinositol 3-kinase (PI3K)-AKT pathway may be involved in the regulation of c-Myc- mediated AS induction by ADI-PEG20...
  101. The role of hepatic insulin resistance on SR-BI dependant HDL cholesterol uptake
    ..The effect of insulin-dependent PI3K signaling on SR- BI subcellular distribution will be examined in cultured hepatocytes, together with the identity ..