p107

Summary

Gene Symbol: p107
Description: RB transcriptional corepressor like 1
Alias: CP107, PRB1, p107, retinoblastoma-like protein 1, 107 kDa retinoblastoma-associated protein, retinoblastoma-like 1
Species: human
Products:     p107

Top Publications

  1. Zhu L, van den Heuvel S, Helin K, Fattaey A, Ewen M, Livingston D, et al. Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev. 1993;7:1111-25 pubmed
    The cellular protein p107 shares many structural and biochemical features with the retinoblastoma gene product, pRB. We have isolated a full-length cDNA for human p107 and have used this clone to study the function of p107...
  2. Weinmann A, Yan P, Oberley M, Huang T, Farnham P. Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. Genes Dev. 2002;16:235-44 pubmed
    ..We suggest that human CpG microarrays, in combination with chromatin immunoprecipitation, will allow rapid identification of target promoters for many mammalian transcription factors. ..
  3. Laplantine E, Rossi F, Sahni M, Basilico C, Cobrinik D. FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest. J Cell Biol. 2002;158:741-50 pubmed
    ..Because mice with targeted mutations of the retinoblastoma (Rb)-related proteins p107 and p130 present severe endochondral bone defects with excessive chondrocyte proliferation, we have investigated ..
  4. Starrett G, Serebrenik A, Roelofs P, McCann J, Verhalen B, Jarvis M, et al. Polyomavirus T Antigen Induces APOBEC3B Expression Using an LXCXE-Dependent and TP53-Independent Mechanism. MBio. 2019;10: pubmed publisher
    ..The cellular portion of the mechanism may also be relevant to nonviral cancers, where genetic mechanisms often activate the RB/E2F axis and APOBEC3B mutagenesis contributes to tumor evolution. ..
  5. Ma L, Li Y, Chen X, Ding M, Wu Y, Yuan Y. SCRaMbLE generates evolved yeasts with increased alkali tolerance. Microb Cell Fact. 2019;18:52 pubmed publisher
    ..One possessed an inversion of 20,743 base pairs within which YEL060C (PRB1) was deleted simultaneously, while another contained a duplication region of 9091 base pairs in length with a ..
  6. Jia C, Shi Y, Xie K, Zhang J, Hu X, Xu K, et al. Vph2 is required for protection against a reductive stress in Candida albicans. Biochem Biophys Res Commun. 2019;512:758-762 pubmed publisher
    ..and displayed increased GSH content and up-regulation of unfolded protein response (UPR)-related genes, such as PRB1 and PMT4...
  7. Zhao M, Zhang L, Qiu X, Zeng F, Chen W, An Y, et al. BLCAP arrests G?/S checkpoint and induces apoptosis through downregulation of pRb1 in HeLa cells. Oncol Rep. 2016;35:3050-8 pubmed publisher
    ..Here our findings suggested that the functional association of BLCAP and Rb1 might play important roles in proliferation and apoptosis of HeLa cells. It suggested that BLCAP could be a novel therapeutic target for cervical cancer. ..
  8. Yamashita T, Segawa K, Jimbow K, Fujinaga K. Both of the N-terminal and C-terminal regions of human papillomavirus type 16 E7 are essential for immortalization of primary rat cells. J Investig Dermatol Symp Proc. 2001;6:69-75 pubmed
    ..collaboration with the activated ras, possibly by interaction with retinoblastoma gene product RB and its related p107. On the other hand, E7 of the cutaneous epidermodysplasia verruciformis-associated HPV5 and HPV8 possess ras-..
  9. Leng X, Noble M, Adams P, Qin J, Harper J. Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4. Mol Cell Biol. 2002;22:2242-54 pubmed
    b>p107 functions to control cell division and development through interaction with members of the E2F family of transcription factors...

More Information

Publications177 found, 100 shown here

  1. Li H, Xu H, Zhou S, Yu Y, Li H, Zhou C, et al. Distribution and transformation of lead in rice plants grown in contaminated soil amended with biochar and lime. Ecotoxicol Environ Saf. 2018;165:589-596 pubmed publisher
    ..Thus, application of biochar and lime in combination is more effective than their individual application in reducing the availability of Pb in the soil and Pb accumulation in brown rice. ..
  2. Squarzanti D, Sorrentino R, Landini M, Chiesa A, Pinato S, Rocchio F, et al. Human papillomavirus type 16 E6 and E7 oncoproteins interact with the nuclear p53-binding protein 1 in an in vitro reconstructed 3D epithelium: new insights for the virus-induced DNA damage response. Virol J. 2018;15:176 pubmed publisher
    ..of pRb, and promotion, E2F1 mediated, of DDR genes translation, by binding to the pRb-like proteins CBP/p300 and p107, that also harbour LXXLL sequence, and via the interaction and activation of several DDR proteins...
  3. Depoortere F, Pirson I, Bartek J, Dumont J, Roger P. Transforming growth factor beta(1) selectively inhibits the cyclic AMP-dependent proliferation of primary thyroid epithelial cells by preventing the association of cyclin D3-cdk4 with nuclear p27(kip1). Mol Biol Cell. 2000;11:1061-76 pubmed
    ..TGFbeta inhibited the phosphorylation of Rb, p107, and p130 induced by TSH, but it weakly affected the phosphorylation state of Rb-related proteins in EGF+serum-..
  4. Lasorella A, Noseda M, Beyna M, Yokota Y, Iavarone A. Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins. Nature. 2000;407:592-8 pubmed
    ..Thus, a dual connection links Id2 and Rb: during normal cell-cycle, Rb prohibits the action of Id2 on its natural targets, but oncogenic activation of the Myc-Id2 transcriptional pathway overrides the tumour-suppressor function of Rb. ..
  5. Xiang X, Lan H, Tang H, Yuan F, Xu Y, Zhao J, et al. Tuberous sclerosis complex 1-mechanistic target of rapamycin complex 1 signaling determines brown-to-white adipocyte phenotypic switch. Diabetes. 2015;64:519-28 pubmed publisher
    ..factor for brown adipocyte determination, was significantly decreased, while mRNAs for retinoblastoma protein, p107 and RIP140, the transcriptional factors for white adipocyte determination, increased in the BAT of Fabp4-Tsc1(-/-) ..
  6. Ito Y, Yoshida H, Tomoda C, Uruno T, Takamura Y, Miya A, et al. Decreased expression of p107 is correlated with anaplastic transformation in papillary carcinoma of the thyroid. Anticancer Res. 2003;23:3819-24 pubmed
    ..However, our knowledge about the expression and physiological role of the third member of this family, p107, remains poor. We therefore investigated p107 expression in various thyroid neoplasms...
  7. Jackson M, Agarwal M, Yang J, Bruss P, Uchiumi T, Agarwal M, et al. p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2. J Cell Sci. 2005;118:1821-32 pubmed
    ..Our studies reported here show that p130 and p107 play a key role in transcriptional repression of genes required for G2 and M in response to DNA damage...
  8. Sandoval R, Pilkinton M, Colamonici O. Deletion of the p107/p130-binding domain of Mip130/LIN-9 bypasses the requirement for CDK4 activity for the dissociation of Mip130/LIN-9 from p107/p130-E2F4 complex. Exp Cell Res. 2009;315:2914-20 pubmed publisher
    ..In mammalian cells, Mip130/LIN-9 specifically associates with the p107/p130-E2F4 repressor complex in G0/G1 and with B-Myb in S-phase...
  9. Rozenblatt Rosen O, Deo R, Padi M, Adelmant G, Calderwood M, Rolland T, et al. Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature. 2012;487:491-5 pubmed publisher
    ..Combining systems-level studies of pathogen-encoded gene products with genomic approaches will facilitate the prioritization of cancer-causing driver genes to advance the understanding of the genetic basis of human cancer...
  10. Tong W, Pollard J. Progesterone inhibits estrogen-induced cyclin D1 and cdk4 nuclear translocation, cyclin E- and cyclin A-cdk2 kinase activation, and cell proliferation in uterine epithelial cells in mice. Mol Cell Biol. 1999;19:2251-64 pubmed
    ..and results in the orderly activation of cyclin E- and cyclin A-cdk2 kinases and hyperphosphorylation of pRb and p107. P4 pretreatment did not alter overall levels of cyclin D1, cdk4, or cdk6 nor their associated kinase activities ..
  11. Korenjak M, Taylor Harding B, Binné U, Satterlee J, Stevaux O, Aasland R, et al. Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes. Cell. 2004;119:181-93 pubmed
    ..These results reveal an extensive evolutionary conservation of specific pRb repressor complexes that physically combine subunits with established roles in the regulation of transcription, DNA replication, and chromatin structure. ..
  12. Hasegawa T, Glavich G, Pahuski M, Short A, Semmes O, Yang L, et al. Characterization and Evidence of the miR-888 Cluster as a Novel Cancer Network in Prostate. Mol Cancer Res. 2018;16:669-681 pubmed publisher
    ..b>Implications: This work reveals a complex noncoding RNA network in the prostate that could be developed as effective diagnostic and therapeutic tools for advanced prostate cancer. Mol Cancer Res; 16(4); 669-81. ©2018 AACR. ..
  13. Martin T, Lou Y, Chou C, Wei S, Sadotra S, Cho C, et al. Structural basis of interaction between dimeric cyclophilin 1 and Myb1 transcription factor in Trichomonas vaginalis. Sci Rep. 2018;8:5410 pubmed publisher
    ..In the complex structure, one Myb1104-111 peptide was bound to each TvCyP1 protomer, with G106-P107 and Y105 fitting well into the active site and auxiliary S2 pocket, respectively...
  14. Park A, Tsunoda I, Yoshie O. Heat shock protein 27 promotes cell cycle progression by down-regulating E2F transcription factor 4 and retinoblastoma family protein p130. J Biol Chem. 2018;293:15815-15826 pubmed publisher
    ..are known to be bound by the E2F family proteins (E2F-1 to E2F-8) and retinoblastoma (RB) family proteins (RB1, p107, and p130), among which E2F-4 and p130 were strongly up-regulated in HSP27-knockdown cells...
  15. Bergholtz H, Lien T, Ursin G, Holmen M, Helland A, Sørlie T, et al. A Longitudinal Study of the Association between Mammographic Density and Gene Expression in Normal Breast Tissue. J Mammary Gland Biol Neoplasia. 2019;: pubmed publisher
  16. Elenbaas J, Mouawad R, Henry R, Arnosti D, Payankaulam S. Role of Drosophila retinoblastoma protein instability element in cell growth and proliferation. Cell Cycle. 2015;14:589-97 pubmed publisher
    ..Intriguingly, cancer associated mutations affecting RB homologs p130 and p107 may similarly induce dominant phenotypes.
  17. Tavakoli R, Vakilian S, Langroudi L, Arefian E, Sahmani M, Soleimani M, et al. The role of miR-17-92 cluster in the expression of tumor suppressor genes in unrestricted somatic stem cells. Biologicals. 2017;46:143-147 pubmed publisher
    ..In conclusion, the role of miR-17-92 in USSCs may provide a better understanding of its function in tumorigenesis and for the possible use in cell therapy of the anti-mir-17-92 cluster. ..
  18. An Y, Wang G, Diao Y, Long Y, Fu X, Weng M, et al. A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes. Dev Cell. 2017;41:382-391.e5 pubmed publisher
    ..targets of Pax7 in MPC, potently repress Prdm16, a BA-specific lineage-determining gene, via the E2F4/p107/p130 transcription repressor complex...
  19. Burkhart D, Ngai L, Roake C, Viatour P, Thangavel C, Ho V, et al. Regulation of RB transcription in vivo by RB family members. Mol Cell Biol. 2010;30:1729-45 pubmed publisher
    ..Using these reporter mice and mutant alleles for Rb, p107, and p130, we found that RB family members modulate Rb transcription in specific cell populations in vivo and in ..
  20. Ginsberg D, Vairo G, Chittenden T, Xiao Z, Xu G, Wydner K, et al. E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev. 1994;8:2665-79 pubmed
    ..regulated, in part, by complex formation with one or more members of the nuclear pocket protein family, RB, p107, and p130. Pocket protein regulation of E2F likely contributes to normal cellular growth control...
  21. Ashe M, Pabon Peña L, Dees E, Price K, Bader D. LEK1 is a potential inhibitor of pocket protein-mediated cellular processes. J Biol Chem. 2004;279:664-76 pubmed
    ..We show that LEK1 interacts with all three pocket proteins, p107, p130, and pRb...
  22. Los A, Vinke F, de Widt J, Topham M, van Blitterswijk W, Divecha N. The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta. J Biol Chem. 2006;281:858-66 pubmed
    ..DGKzeta also binds to the pRB-related pocket proteins p107 and p130 in vitro and in cells...
  23. Xiaojuan F, Kai Y, Hanxue L, Qin Z, Dan C. [Effects and mechanism of the circadian clock gene Per1 on the proliferation, apoptosis, cycle, and tumorigenicity in vivo of human oral squamous cell carcinoma]. Hua Xi Kou Qiang Yi Xue Za Zhi. 2016;34:255-61 pubmed
    ..Further studies on Per1 may elucidate cancer development and provide novel effective molecular targets for cancer treatment. ..
  24. Magae J, Wu C, Illenye S, Harlow E, Heintz N. Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members. J Cell Sci. 1996;109 ( Pt 7):1717-26 pubmed
    ..is influenced by association with the members of the retinoblastoma tumor suppressor protein family (pRb, p107, and p130)...
  25. Iavarone A, Massague J. E2F and histone deacetylase mediate transforming growth factor beta repression of cdc25A during keratinocyte cell cycle arrest. Mol Cell Biol. 1999;19:916-22 pubmed
    ..This mechanism is part of a program that places keratinocytes in the quiescent state following the initial drop in Cdk activity caused by cell exposure to TGF-beta. ..
  26. Marampon F, Casimiro M, Fu M, Powell M, Popov V, Lindsay J, et al. Nerve Growth factor regulation of cyclin D1 in PC12 cells through a p21RAS extracellular signal-regulated kinase pathway requires cooperative interactions between Sp1 and nuclear factor-kappaB. Mol Biol Cell. 2008;19:2566-78 pubmed publisher
    ..NGF induction via Sp1 involved the formation of a Sp1/p50/p107 complex. Cyclin D1 induction by NGF governs differentiation and neurite outgrowth in PC12 cells.
  27. von Eyss B, Maaskola J, Memczak S, Möllmann K, Schuetz A, Loddenkemper C, et al. The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation. EMBO J. 2012;31:972-85 pubmed publisher
    ..Our work reveals that HELLS is important for E2F3 in tumour cell proliferation. ..
  28. Naert T, Colpaert R, Van Nieuwenhuysen T, Dimitrakopoulou D, Leoen J, Haustraete J, et al. CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis. Sci Rep. 2016;6:35264 pubmed publisher
  29. Oshikawa M, Okada K, Tabata H, Nagata K, Ajioka I. Dnmt1-dependent Chk1 pathway suppression is protective against neuron division. Development. 2017;144:3303-3314 pubmed publisher
    ..Here, we have found that acute inactivation of retinoblastoma (Rb) family proteins (Rb, p107 and p130) in mouse postmitotic neurons leads to cell death after S-phase progression...
  30. Ferreira R, Magnaghi Jaulin L, Robin P, Harel Bellan A, Trouche D. The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase. Proc Natl Acad Sci U S A. 1998;95:10493-8 pubmed
    ..Here, we show that the two other members of the pocket proteins family, p107 and p130, also are able to interact physically with HDAC1 in live cells...
  31. Vilas J, Ferreirós A, Carneiro C, Morey L, Da Silva Álvarez S, Fernandes T, et al. Transcriptional regulation of Sox2 by the retinoblastoma family of pocket proteins. Oncotarget. 2015;6:2992-3002 pubmed
    ..The members of the retinoblastoma family of pocket proteins, pRb, p107 and p130, are negative regulators of the cell cycle with tumor suppressor activity and with roles in ..
  32. Gibbs E, Pan Z, Niu H, Hurwitz J. Studies on the in vitro phosphorylation of HSSB-p34 and -p107 by cyclin-dependent kinases. Cyclin-substrate interactions dictate the efficiency of phosphorylation. J Biol Chem. 1996;271:22847-54 pubmed
    ..or RPA), which plays an essential role in DNA replication, repair, and recombination, and the tumor suppressor p107 which acts to negatively regulate cell growth...
  33. Flowers S, Patel P, Gleicher S, Amer K, Himelman E, Goel S, et al. p107-Dependent recruitment of SWI/SNF to the alkaline phosphatase promoter during osteoblast differentiation. Bone. 2014;69:47-54 pubmed publisher
    ..The role of the following proteins, pRB, p107 and p130, is particularly significant in differentiation to the osteoblast lineage, as human germ-line mutations of ..
  34. Eyvani H, Moghaddaskho F, Kabuli M, Zekri A, Momeny M, Tavakkoly Bazzaz J, et al. Arsenic trioxide induces cell cycle arrest and alters DNA methylation patterns of cell cycle regulatory genes in colorectal cancer cells. Life Sci. 2016;167:67-77 pubmed publisher
    ..Our methylation analysis indicated that only promoters of RBL1 (p107), CHFR and p16 genes were aberrantly methylated in three cell lines...
  35. Subash Babu P, Li D, Alshatwi A. In vitro cytotoxic potential of friedelin in human MCF-7 breast cancer cell: Regulate early expression of Cdkn2a and pRb1, neutralize mdm2-p53 amalgamation and functional stabilization of p53. Exp Toxicol Pathol. 2017;69:630-636 pubmed publisher
    ..In conclusion, friedelin effectively inhibit breast cancer MCF-7 cell growth, it was associated with early expression of Cdkn1a, pRb2 and activation of p53 and caspases. ..
  36. Vidal M, Brachmann R, Fattaey A, Harlow E, Boeke J. Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions. Proc Natl Acad Sci U S A. 1996;93:10315-20 pubmed
    ..They should also facilitate the selection of dissociator molecules that could be used as therapeutic agents. ..
  37. Pellatt A, Mullany L, Herrick J, Sakoda L, Wolff R, Samowitz W, et al. The TGFβ-signaling pathway and colorectal cancer: associations between dysregulated genes and miRNAs. J Transl Med. 2018;16:191 pubmed publisher
    ..These interactions are associated with unique clinical characteristics that may provide targets for further investigations. ..
  38. Agrelo R, Kishimoto H, Novatchkova M, Peraza V, Paolino M, Souabni A, et al. SATB1 collaborates with loss of p16 in cellular transformation. Oncogene. 2013;32:5492-500 pubmed publisher
    ..A combined deletion of the RB proteins, RB, p107 and p130 (triple-mutant; TM), prevents SATB1-induced G1 arrest, which is restored upon the reintroduction of RB ..
  39. Wang Q, Lv H, Lv W, Shi M, Zhang M, Luan M, et al. Genome-wide haplotype association study identifies BLM as a risk gene for prostate cancer in Chinese population. Tumour Biol. 2015;36:2703-7 pubmed publisher
    ..1 had significant association with PC (P = 2.37E-11). To our knowledge, this is the first genetic association study to show the significant association between BLM gene and PC susceptibility in Chinese population. ..
  40. Li T, Zheng Q, An J, Wu M, Li H, Gui X, et al. SET1A Cooperates With CUDR to Promote Liver Cancer Growth and Hepatocyte-like Stem Cell Malignant Transformation Epigenetically. Mol Ther. 2016;24:261-275 pubmed publisher
    ..CUDR enhances the phosphorylation of RB1, C-myc expression, and the interplay between the SET1A and pRB1. Notably, CUDR acts as a sponge cushion that shows a link between SET1A and pRB1, producing a activated pRB1-SET1A ..
  41. Beijersbergen R, Kerkhoven R, Zhu L, Carlee L, Voorhoeve P, Bernards R. E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev. 1994;8:2680-90 pubmed
    ..E2F DNA-binding activity is found in complex with the retinoblastoma protein, pRb, and with the pRb-related p107 and p130. To date, cDNAs for three members of the E2F gene family have been isolated...
  42. Davies R, Hicks R, Crook T, Morris J, Vousden K. Human papillomavirus type 16 E7 associates with a histone H1 kinase and with p107 through sequences necessary for transformation. J Virol. 1993;67:2521-8 pubmed
    ..with a histone H1 kinase at the G2/M phase of the cell cycle and an ability to bind the RB-related protein p107. The region of E7 identified previously as important for RB binding was found to be involved in the association ..
  43. Hesbacher S, Pfitzer L, Wiedorfer K, Angermeyer S, Borst A, Haferkamp S, et al. RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells. Oncotarget. 2016;7:32956-68 pubmed publisher
    The pocket protein (PP) family consists of the three members RB1, p107 and p130 all possessing tumor suppressive properties. Indeed, the PPs jointly control the G1/S transition mainly by inhibiting E2F transcription factors...
  44. Rocha Sanchez S, Scheetz L, Contreras M, Weston M, Korte M, McGee J, et al. Mature mice lacking Rbl2/p130 gene have supernumerary inner ear hair cells and supporting cells. J Neurosci. 2011;31:8883-93 pubmed publisher
    ..The retinoblastoma (pRB) family of cell cycle regulators, Rb1, Rbl1 (p107), and Rbl2 (p130), regulate the G(1)- to S-phase transition in proliferating cells...
  45. Sengupta S, Lingnurkar R, Carey T, Pomaville M, Kar P, Feig M, et al. The Evolutionarily Conserved C-terminal Domains in the Mammalian Retinoblastoma Tumor Suppressor Family Serve as Dual Regulators of Protein Stability and Transcriptional Potency. J Biol Chem. 2015;290:14462-75 pubmed publisher
    ..We find that steady state levels of all RB family members, RB, p107, and p130, were diminished during embryonic stem cell differentiation concomitant with their target gene ..
  46. Sengupta S, Henry R. Regulation of the retinoblastoma-E2F pathway by the ubiquitin-proteasome system. Biochim Biophys Acta. 2015;1849:1289-97 pubmed publisher
    The retinoblastoma tumor suppressor (RB) and its related family members p107 and p130 regulate cell proliferation through the transcriptional repression of genes involved in cellular G1 to S phase transition...
  47. Dyson N, Guida P, M nger K, Harlow E. Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins. J Virol. 1992;66:6893-902 pubmed
    ..pRB binding, these regions are necessary for E1A association with several other cellular proteins, including p130, p107, cyclin A, and p33cdk2...
  48. Sterner J, Dew Knight S, Musahl C, Kornbluth S, Horowitz J. Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. Mol Cell Biol. 1998;18:2748-57 pubmed
    ..Full-length Rb and MCM7 form protein complexes in vitro, and the amino termini of two Rb-related proteins, p107 and p130, also bind MCM7...
  49. Cavallotti I, De Luca L, D Aponte A, De Falco M, Acanfora F, Visciano M, et al. Expression of the retinoblastoma-related p107 and Rb2/p130 genes in human placenta: an immunohistochemical study. Histol Histopathol. 2001;16:1057-60 pubmed publisher
    ..observations we have investigated the immunohistochemical expression pattern of the Retinoblastoma family members, p107 and Rb2/p130 in human placenta samples in first trimester and full-term placental sections...
  50. Manconi B, Castagnola M, Cabras T, Olianas A, Vitali A, Desiderio C, et al. The intriguing heterogeneity of human salivary proline-rich proteins: Short title: Salivary proline-rich protein species. J Proteomics. 2016;134:47-56 pubmed publisher
    ..They are encoded by six genes, clustered on chromosome 12p13.2: PRH1-2 encode aPRPs, PRB1-4 encode bPRPs and gPRPs...
  51. Al Saran N, Subash Babu P, Al Nouri D, Alfawaz H, Alshatwi A. Zinc enhances CDKN2A, pRb1 expression and regulates functional apoptosis via upregulation of p53 and p21 expression in human breast cancer MCF-7 cell. Environ Toxicol Pharmacol. 2016;47:19-27 pubmed publisher
    ..Zinc depleted MCF-7 cells expressed significantly (p?0.001) decreased levels of CDKN2A, pRb1, p53 and increased the level of mdm2 expression...
  52. Norouzi M, Abdali Z, Liu S, Miller D. Salinomycin-loaded Nanofibers for Glioblastoma Therapy. Sci Rep. 2018;8:9377 pubmed publisher
    ..In general, the results indicated anti-tumor activity of the Sali-loaded NFs suggesting their potential applications as implantable drug delivery systems in the brain upon surgical resection of the tumor. ..
  53. Fan S, Yuan R, Ma Y, Xiong J, Meng Q, Erdos M, et al. Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding. Oncogene. 2001;20:4827-41 pubmed
    ..of wild-type BRCA1 (wtBRCA1) did not cause cell cycle arrest but did cause down-regulation of expression of RB, p107, p130, and other proteins (e.g., p300), associated with increased sensitivity to DNA-damaging agents...
  54. Zhu S, Zhao L, Li Y, Hou P, Yao R, Tan J, et al. Suppression of RAD21 Induces Senescence of MDA-MB-231 Human Breast Cancer Cells Through RB1 Pathway Activation Via c-Myc Downregulation. J Cell Biochem. 2016;117:1359-69 pubmed publisher
    ..of c-Myc and its targets, including CDK4, a negative regulator of RB1, and blockedRB1 phosphorylation (pRB1), and the RB1-mediated transcriptional repression of E2F...
  55. Møller T, Hay J, Saxton M, Bunting K, Petersen E, Kjærulff S, et al. Human ?-defensin-2 production from S. cerevisiae using the repressible MET17 promoter. Microb Cell Fact. 2017;16:11 pubmed publisher
    ..using the repressible MET17 promoter system than when using the strong constitutive promoter from proteinase B (PRB1) in a yeast strain developed for high-level commercial production of recombinant proteins...
  56. Dufau M, Liao M, Zhang Y. Participation of signaling pathways in the derepression of luteinizing hormone receptor transcription. Mol Cell Endocrinol. 2010;314:221-7 pubmed publisher
    ..for Sp1 phosphorylation by phosphatidylinositol 3-kinase/protein kinase Czeta (PI3K/PKCzeta) at Ser641, leading to p107 repressor derecruitment and LHR transcriptional activation...
  57. Kooi I, van Mil S, MacPherson D, Mol B, Moll A, Meijers Heijboer H, et al. Genomic landscape of retinoblastoma in Rb-/- p130-/- mice resembles human retinoblastoma. Genes Chromosomes Cancer. 2017;56:231-242 pubmed publisher
    ..by deleting the genes encoding for retinoblastoma susceptibility protein pRb and one of its family members p107 or p130...
  58. Benavente C, Finkelstein D, Johnson D, Marine J, Ashery Padan R, Dyer M. Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression. Oncotarget. 2014;5:9594-608 pubmed
    ..In this study, we found that E2f family members play distinct roles in the development and tumorigenesis. In Rb;p107-deficient retinae, E2f1 and E2f3 inactivation rescued tumor formation but only E2f1 rescued the retinal development ..
  59. Takahashi Y, Rayman J, Dynlacht B. Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. Genes Dev. 2000;14:804-16 pubmed
    ..These findings suggest that repression and activation of E2F-responsive genes may occur through distinct E2F heterodimers that direct the sequential recruitment of enzymes able to deacetylate and then acetylate core histones. ..
  60. Mele D, Bista P, Baez D, Huber B. Dipeptidyl peptidase 2 is an essential survival factor in the regulation of cell quiescence. Cell Cycle. 2009;8:2425-34 pubmed
    ..cells exhibit an increase in early G(1)/S progressors, with increases in the levels of retinoblastoma (pRb), p107 and cyclin D proteins...
  61. Lin M, Eng C, Hawk E, Huang M, Lin J, Gu J, et al. Identification of polymorphisms in ultraconserved elements associated with clinical outcomes in locally advanced colorectal adenocarcinoma. Cancer. 2012;118:6188-98 pubmed publisher
    ..The results suggested that SNPs within UCEs may be valuable prognostic biomarkers for patients with locally advanced CRC who receive 5-fluorouracil-based chemotherapy. ..
  62. Xie C, Lu H, Nomura A, Hanse E, Forster C, Parker J, et al. Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas. Mol Cancer. 2015;14:93 pubmed publisher
    ..model in which Rb1 and Pten were conditionally deleted from retinal progenitor cells using Chx10-Cre, whereas Rbl1 (p107) was constitutively deleted...
  63. Mark K, Meza Gutierrez F, Johnson J, Newton B, Krogan N, Toczyski D. Prb1 Protease Activity Is Required for Its Recognition by the F-Box Protein Saf1. Biochemistry. 2015;54:4423-6 pubmed publisher
    ..Here, we characterize the interaction of the F-box protein Saf1 with Prb1, one of its vacuolar protease substrates...
  64. Zhang J, Loyd M, Randall M, Morris J, Shah J, Ney P. Repression by RB1 characterizes genes involved in the penultimate stage of erythroid development. Cell Cycle. 2015;14:3441-53 pubmed publisher
    Retinoblastoma-1 (RB1), and the RB1-related proteins p107 and p130, are key regulators of the cell cycle. Although RB1 is required for normal erythroid development in vitro, it is largely dispensable for erythropoiesis in vivo...
  65. Mushtaq M, Gaza H, Kashuba E. Role of the RB-Interacting Proteins in Stem Cell Biology. Adv Cancer Res. 2016;131:133-57 pubmed publisher
    ..In this review we have focused on 27 RB-binding partners that may have potential roles in different aspects of stem cell biology. ..
  66. Ponnusamy M, Li P, Wang K. Understanding cardiomyocyte proliferation: an insight into cell cycle activity. Cell Mol Life Sci. 2017;74:1019-1034 pubmed publisher
    ..activators (cyclins and CDKs), inhibitors (p21, p27, p57, p16, and p18), and cell-cycle-associated proteins (Rb, p107, and p130) in cardiomyocytes during gestation and postnatal life are described in this review...
  67. Mages C, Wintsche A, Bernhart S, Müller G. The DREAM complex through its subunit Lin37 cooperates with Rb to initiate quiescence. elife. 2017;6: pubmed publisher
    ..The Rb-related proteins p107 and p130, which are components of the DREAM complex, had been suggested to be responsible for a continued ability ..
  68. Farkas T, Hansen K, Holm K, Lukas J, Bartek J. Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4. J Biol Chem. 2002;277:26741-52 pubmed
    The "pocket proteins" pRb (retinoblastoma tumor suppressor protein), p107, and p130 regulate cell proliferation via phosphorylation-sensitive interactions with E2F transcription factors and other proteins...
  69. Pilkinton M, Sandoval R, Colamonici O. Mammalian Mip/LIN-9 interacts with either the p107, p130/E2F4 repressor complex or B-Myb in a cell cycle-phase-dependent context distinct from the Drosophila dREAM complex. Oncogene. 2007;26:7535-43 pubmed
    ..In G(0)/early G(1), Mip/LIN-9 forms a complex with E2F4 and p107 or p130, while in late G(1)/S phase, it associates with B-Myb...
  70. Guiley K, Liban T, Felthousen J, Ramanan P, Litovchick L, Rubin S. Structural mechanisms of DREAM complex assembly and regulation. Genes Dev. 2015;29:961-74 pubmed publisher
    ..cycle genes during quiescence through scaffolding MuvB proteins with E2F4/5 and the Rb tumor suppressor paralog p107 or p130...
  71. Peek G, Tollefsbol T. Combinatorial PX-866 and Raloxifene Decrease Rb Phosphorylation, Cyclin E2 Transcription, and Proliferation of MCF-7 Breast Cancer Cells. J Cell Biochem. 2016;117:1688-96 pubmed publisher
    ..Reduced phosphorylation of p107 and substantial reduction of Rb phosphorylation were observed in response...
  72. Tonks I, Mukhopadhyay P, Schroder W, Sorolla A, Mould A, Handoko H, et al. Melanocyte transformation requires complete loss of all pocket protein function via a mechanism that mitigates the need for MAPK pathway activation. Oncogene. 2017;36:3789-3795 pubmed publisher
    ..However, there are also two other PPs, p107 and p130, which, when phosphorylated by CDK-cyclin complexes, play a role in permitting cell progression...
  73. Kim Y, Otterson G, Kratzke R, Coxon A, Kaye F. Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein. Mol Cell Biol. 1994;14:7256-64 pubmed
    The growth suppressor activities of the RB and p107 products are believed to be mediated by the reversible binding of a heterogeneous family of cellular proteins to a conserved T/E1A pocket domain that is present within both proteins...
  74. Ikeda M, Jakoi L, Nevins J. A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. Proc Natl Acad Sci U S A. 1996;93:3215-20 pubmed
    ..E2F4 then associates with the Rb-related p107 protein as cells enter S phase...
  75. Wang S, Nath N, Adlam M, Chellappan S. Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function. Oncogene. 1999;18:3501-10 pubmed
    The retinoblastoma tumor suppressor protein and its family members, p107 and p130, are major regulators of the mammalian cell cycle...
  76. Xu L, Sowa M, Chen J, Li X, Gygi S, Harper J. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. Mol Biol Cell. 2008;19:5059-71 pubmed publisher
    ..These data suggest that the FTS/Hook/FHIP complex functions to promote vesicle trafficking and/or fusion via the HOPS complex. ..
  77. Liban T, Medina E, Tripathi S, Sengupta S, Henry R, Buchler N, et al. Conservation and divergence of C-terminal domain structure in the retinoblastoma protein family. Proc Natl Acad Sci U S A. 2017;114:4942-4947 pubmed publisher
    The retinoblastoma protein (Rb) and the homologous pocket proteins p107 and p130 negatively regulate cell proliferation by binding and inhibiting members of the E2F transcription factor family...
  78. Alessio N, Capasso S, Ferone A, Di Bernardo G, Cipollaro M, Casale F, et al. Misidentified Human Gene Functions with Mouse Models: The Case of the Retinoblastoma Gene Family in Senescence. Neoplasia. 2017;19:781-790 pubmed publisher
    ..e., RB1, RB2/P130, and P107), all of which participate in controlling the cell cycle and associated phenomena, including proliferation, ..
  79. Veal E, Eisenstein M, Tseng Z, Gill G. A cellular repressor of E1A-stimulated genes that inhibits activation by E2F. Mol Cell Biol. 1998;18:5032-41 pubmed
  80. Bruno T, De Angelis R, De Nicola F, Barbato C, Di Padova M, Corbi N, et al. Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb. Cancer Cell. 2002;2:387-99 pubmed
    ..These findings indicate the existence of a pathway of Rb regulation supporting Che-1 as the cellular counterpart of DNA tumor virus oncoproteins. ..
  81. Jayadeva G, Kurimchak A, Garriga J, Sotillo E, Davis A, Haines D, et al. B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation. J Biol Chem. 2010;285:29863-73 pubmed publisher
    ..of a PP2A trimeric holoenzyme containing B55?, which plays a major role in restricting the phosphorylation state of p107 and inducing its activation in human cells...
  82. Song Y, Sullivan T, Klarmann K, Gilbert D, O Sullivan T, Lu L, et al. RB inactivation in keratin 18 positive thymic epithelial cells promotes non-cell autonomous T cell hyperproliferation in genetically engineered mice. PLoS ONE. 2017;12:e0171510 pubmed publisher
    ..18 positive TEC was sufficient for thymocyte hyperplasia, we conditionally inactivated Rb and its family members p107 and p130 in K18+ TEC in genetically engineered mice (TgK18GT121; K18 mice)...
  83. Vélez Cruz R, Johnson D. The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts. Int J Mol Sci. 2017;18: pubmed publisher
    ..RB, in some cases, acts through its interaction with E2F1, other members of the pocket protein family (p107 and p130), and/or chromatin remodelers and modifiers...
  84. Pentimalli F, Forte I, Esposito L, Indovina P, Iannuzzi C, Alfano L, et al. RBL2/p130 is a direct AKT target and is required to induce apoptosis upon AKT inhibition in lung cancer and mesothelioma cell lines. Oncogene. 2018;37:3657-3671 pubmed publisher
    The retinoblastoma (RB) protein family includes RB1/p105, RBL1/p107, and RBL2/p130, which are key factors in cell-cycle regulation and stand at the crossroads of multiple pathways dictating cell fate decisions...
  85. Garriga J, Jayaraman A, Limon A, Jayadeva G, Sotillo E, Truongcao M, et al. A dynamic equilibrium between CDKs and PP2A modulates phosphorylation of pRB, p107 and p130. Cell Cycle. 2004;3:1320-30 pubmed
    ..Moreover, dephosphorylation of p130 and p107 in cell extracts is inhibited by concentrations of okadaic acid known to inhibit PP2A, but not PP1...
  86. Huh K, DeMasi J, Ogawa H, Nakatani Y, Howley P, Munger K. Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600. Proc Natl Acad Sci U S A. 2005;102:11492-7 pubmed
    ..of the HPV-16 E7 oncoprotein are the retinoblastoma tumor suppressor protein pRB and the related pocket proteins p107 and p130...
  87. Mileo A, Mattarocci S, Matarrese P, Anticoli S, Abbruzzese C, Catone S, et al. Hepatitis C virus core protein modulates pRb2/p130 expression in human hepatocellular carcinoma cell lines through promoter methylation. J Exp Clin Cancer Res. 2015;34:140 pubmed publisher
    ..e. pRb, p107 and pRb2/p130...
  88. Wang L, Zhang T, Xi Y, Yang C, Sun C, Li D. Sirtuin 1 promotes the proliferation of C2C12 myoblast cells via the myostatin signaling pathway. Mol Med Rep. 2016;14:1309-15 pubmed publisher
    ..Additionally, NAM significantly repressed the expression of MyoD and the phosphorylation of P107 (p?P107), but enhanced the expression of MSTN and the protein expression of P107...
  89. Liban T, Thwaites M, Dick F, Rubin S. Structural Conservation and E2F Binding Specificity within the Retinoblastoma Pocket Protein Family. J Mol Biol. 2016;428:3960-3971 pubmed publisher
    The human pocket proteins retinoblastoma (Rb), p107, and p130 are critical negative regulators of the cell cycle and contribute to tumor suppression...
  90. Lee J, Jung J, Chae Y, Park H, Kim W, Lee S, et al. Long Noncoding RNA snaR Regulates Proliferation, Migration and Invasion of Triple-negative Breast Cancer Cells. Anticancer Res. 2016;36:6289-6295 pubmed
    ..Among 90 lncRNAs, E2F transcription factor 4, p107/p130-binding (E2F4) antisense, insulin-like growth factor 2 antisense (IGF2AS), snaR, and small nucleolar RNA host ..
  91. Zhu L, Xie E, Chang L. Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins. Mol Cell Biol. 1995;15:3552-62 pubmed
    Although many lines of evidence indicate that the cellular protein p107 is closely related to the retinoblastoma protein, the exact function of the p107 gene and its regulation are presently not known...
  92. Verona R, Moberg K, Estes S, Starz M, Vernon J, Lees J. E2F activity is regulated by cell cycle-dependent changes in subcellular localization. Mol Cell Biol. 1997;17:7268-82 pubmed
    ..Consequently, in cycling cells, the majority of the p107-E2F, p130-E2F, and free E2F complexes remain in the cytoplasm...