Gene Symbol: p0071
Description: plakophilin 4
Alias: p0071, plakophilin-4, catenin 4
Species: human
Products:     p0071

Top Publications

  1. Walter B, Krebs U, Berger I, Hofmann I. Protein p0071, an armadillo plaque protein of adherens junctions, is predominantly expressed in distal renal tubules. Histochem Cell Biol. 2010;133:69-83 pubmed publisher
    Protein p0071 is a member of the p120-subfamily of armadillo proteins and is well known as a junctional plaque component involved in cell-cell adhesion, especially in adherens junctions...
  2. Wolf A, Keil R, Götzl O, Mun A, Schwarze K, Lederer M, et al. The armadillo protein p0071 regulates Rho signalling during cytokinesis. Nat Cell Biol. 2006;8:1432-40 pubmed
    ..Here, we show that the armadillo protein p0071, unlike its relative p120(ctn), is localized at the midbody during cytokinesis and is essential for cell division...
  3. Calkins C, Hoepner B, Law C, Novak M, Setzer S, Hatzfeld M, et al. The Armadillo family protein p0071 is a VE-cadherin- and desmoplakin-binding protein. J Biol Chem. 2003;278:1774-83 pubmed
    b>p0071, a member of the armadillo protein family, localizes to both adherens junctions and desmosomes in epithelial cells and exhibits homology to the adherens junction protein p120 and the desmosomal protein plakophilin-1...
  4. Cho K, Lee M, Gu D, Munoz W, Ji H, Kloc M, et al. Kazrin, and its binding partners ARVCF- and delta-catenin, are required for Xenopus laevis craniofacial development. Dev Dyn. 2011;240:2601-12 pubmed publisher
    ..protein Kazrin associates with multifunctional entities including p120-subfamily members (ARVCF-, delta-, and p0071-catenin)...
  5. Franke W, Rickelt S, Zimbelmann R, Dörflinger Y, Kuhn C, Frey N, et al. Striatins as plaque molecules of zonulae adhaerentes in simple epithelia, of tessellate junctions in stratified epithelia, of cardiac composite junctions and of various size classes of lateral adherens junctions in cultures of epithelia- and carcinom. Cell Tissue Res. 2015;359:779-97 pubmed publisher
    ..with E-cadherin or E-N-cadherin heterodimers and with the plaque proteins α- and β-catenin, p120 and p0071. In some epithelia and carcinomas and in cultured cells derived therefrom, striatins are also seen in lateral AJs...
  6. Zhao Z, Ma X, Sung D, Li M, Kosti A, Lin G, et al. microRNA-449a functions as a tumor suppressor in neuroblastoma through inducing cell differentiation and cell cycle arrest. RNA Biol. 2015;12:538-54 pubmed publisher
  7. Hendley A, Provost E, Bailey J, WANG Y, Cleveland M, Blake D, et al. p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas. Dev Biol. 2015;399:41-53 pubmed publisher
    ..expression of adherens junction proteins E-cadherin, β-catenin, and α-catenin, p120 catenin family members p0071, ARVCF, and δ-catenin remained present at cell membranes in homozygous p120(f/f) pancreases, potentially ..
  8. Abreu Velez A, Howard M, Velazquez Velez J. Cardiac rhythm and pacemaking abnormalities in patients affected by endemic pemphigus in Colombia may be the result of deposition of autoantibodies, complement, fibrinogen, and other molecules. Heart Rhythm. 2018;15:725-731 pubmed publisher
    ..01). The patient antibodies colocalized with commercial antibodies to desmoplakins I and II, p0071, armadillo repeat gene deleted in velo-cardio-facial syndrome (ARVCF), and myocardium-enriched zonula occludens-1-..
  9. Jung S, Kim M, Lee S, Park H, Choi H, Maeng L, et al. Whole-exome sequencing identifies recurrent AKT1 mutations in sclerosing hemangioma of lung. Proc Natl Acad Sci U S A. 2016;113:10672-7 pubmed publisher
    ..These genomic features of PSH identified in the present study provide clues to understanding the biology of PSH and for differential genomic diagnosis of lung tumors. ..

More Information


  1. Ajiro M, Jia R, Yang Y, Zhu J, Zheng Z. A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells. Nucleic Acids Res. 2016;44:1854-70 pubmed publisher
    ..These data indicate that SRSF3 affects a global change of gene expression to maintain cell homeostasis. ..
  2. Tenhagen M, Klarenbeek S, Braumuller T, Hofmann I, van der Groep P, Ter Hoeve N, et al. p120-Catenin Is Critical for the Development of Invasive Lobular Carcinoma in Mice. J Mammary Gland Biol Neoplasia. 2016;21:81-88 pubmed
    ..redundancy of p120 family members was observed in mouse ILC development, as expression and localization of ARVCF, p0071 or ?-catenin was unaltered in ILCs from triple-knockout mice...
  3. Kennedy J, Khabibullin D, Henske E. Mechanisms of pulmonary cyst pathogenesis in Birt-Hogg-Dube syndrome: The stretch hypothesis. Semin Cell Dev Biol. 2016;52:47-52 pubmed publisher
    ..via the interaction of FLCN with FNIP1/2, and cell-cell adhesion via the physical interaction of FLCN with plakophilin 4 (PKP4), an armadillo-repeat containing protein that interacts with E-cadherin and is a component of the ..
  4. Marples B, McGee M, Callan S, Bowen S, Thibodeau B, Michael D, et al. Cranial irradiation significantly reduces beta amyloid plaques in the brain and improves cognition in a murine model of Alzheimer's Disease (AD). Radiother Oncol. 2016;118:43-51 pubmed publisher
    ..However, longer-term studies are needed to define the precise underlying mechanism and longevity of this response. ..
  5. Zaragoza M, Fung L, Jensen E, Oh F, Cung K, McCarthy L, et al. Exome Sequencing Identifies a Novel LMNA Splice-Site Mutation and Multigenic Heterozygosity of Potential Modifiers in a Family with Sick Sinus Syndrome, Dilated Cardiomyopathy, and Sudden Cardiac Death. PLoS ONE. 2016;11:e0155421 pubmed publisher
    ..357-2A>G, a novel heterozygous splice-site mutation as the primary mutation with rare or novel variants in HCN4, MYBPC3, PKP4, TMPO, TTN, DMPK and KCNJ10 as potential modifiers and a mechanism consistent with haploinsufficiency. ..
  6. Ohno H, Hirabayashi S, Iizuka T, Ohnishi H, Fujita T, Hata Y. Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells. Oncogene. 2002;21:7042-9 pubmed
    PAPIN has six PDZ domains and interacts with p0071, a catenin-related protein. Recent studies have revealed that catenins determine the subcellular localization of some PDZ proteins...
  7. Hatzfeld M, Nachtsheim C. Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins. J Cell Sci. 1996;109 ( Pt 11):2767-78 pubmed
    ..Here we report cloning of a cDNA encoding a new armadillo family member, p0071, closely related to p120 and B6P/plakophilin and more distantly related to armadillo, plakoglobin, beta-catenin ..
  8. Abreu Velez A, Valencia Yepes C, Upegui Zapata Y, Upegui Quiceno E, Mesa Herrera N, Velazquez Velez J, et al. Patients with a new variant of endemic pemphigus foliaceus have autoantibodies against arrector pili muscle, colocalizing with MYZAP, p0071, desmoplakins 1 and 2 and ARVCF. Clin Exp Dermatol. 2017;42:874-880 pubmed publisher
    ..We identified a new variant of endemic pemphigus foliaceus in El Bagre, Colombia, South America, which we term El Bagre-EPF, and observed reactivity to arrector pili muscle (APM), thus we tested for autoimmunity to APM...
  9. Becher A, Eiseler T, Porzner M, Walther P, Keil R, Bobrovich S, et al. The armadillo protein p0071 controls KIF3 motor transport. J Cell Sci. 2017;130:3374-3387 pubmed publisher
    We here report a novel function of the armadillo protein p0071 (also known as PKP4) during transport mediated by the KIF3 transport complex...
  10. Maldarelli F, Wu X, Su L, Simonetti F, Shao W, Hill S, et al. HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science. 2014;345:179-83 pubmed publisher
    ..Our findings show that HIV integration sites can play a critical role in expansion and persistence of HIV-infected cells. ..
  11. Keil R, Schulz J, Hatzfeld M. p0071/PKP4, a multifunctional protein coordinating cell adhesion with cytoskeletal organization. Biol Chem. 2013;394:1005-17 pubmed publisher
    b>P0071 is a member of a subfamily of armadillo proteins that also comprises p120-catenin (p120ctn), ?-catenin/NPRAP, ARVCF and the more distantly related plakophilins 1-3...
  12. Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, et al. PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071. J Biol Chem. 2000;275:29875-80 pubmed
    ..b>p0071, a ubiquitous isoform of NPRAP/delta-catenin, is localized at desmosomes in HeLa and A431 cells and at adherens ..
  13. Qu K, Lu Y, Lin N, Singh R, Xu X, Payan D, et al. Computational and experimental studies on human misshapen/NIK-related kinase MINK-1. Curr Med Chem. 2004;11:569-82 pubmed
    ..Further medicinal chemistry compound structure optimization and kinase assays are underway. ..
  14. Hofmann I, Kuhn C, Franke W. Protein p0071, a major plaque protein of non-desmosomal adhering junctions, is a selective cell-type marker. Cell Tissue Res. 2008;334:381-99 pubmed publisher
    Protein p0071, which originally was introduced as a member of the p120-subfamily of armadillo proteins, common to desmosomes and adhaerens junctions (AJs) and to several other cell structures (centrosomes, midbodies), has been localized ..
  15. McDonald C, Chen F, Ollendorff V, Ogura Y, Marchetto S, Lecine P, et al. A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling. J Biol Chem. 2005;280:40301-9 pubmed
    ..These studies identify Erbin as a regulator of Nod2 signaling and demonstrate a novel role for Erbin in inflammatory responses. ..
  16. Jaulin Bastard F, Arsanto J, Le Bivic A, Navarro C, Vely F, Saito H, et al. Interaction between Erbin and a Catenin-related protein in epithelial cells. J Biol Chem. 2002;277:2869-75 pubmed
    ..We show here that Erbin interacts with p0071 (also called plakophilin-4), an armadillo repeat protein linked to the cytoskeleton...
  17. Stenzel N, Fetzer C, Heumann R, Erdmann K. PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells. J Cell Sci. 2009;122:3374-84 pubmed publisher
    ..We demonstrate that the FERM domain and binding of the PDZ2 domain to the armadillo protein p0071 are required for basolateral restriction of FRMPD2...
  18. Izawa I, Nishizawa M, Tomono Y, Ohtakara K, Takahashi T, Inagaki M. ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells. Genes Cells. 2002;7:475-85 pubmed
    ..library, using the carboxyl-terminal fragment of ERBIN containing PDZ domain as the bait, and we isolated p0071 (also called plakophilin-4) as an ERBIN-interacting protein...
  19. Abreu Velez A, Yi H, Warfvinge G, Howard M. Autoantibodies to full body vascular cell junctions colocalize with MYZAP, ARVCF, desmoplakins I and II and p0071 in endemic pemphigus in Colombia, South America. Int J Dermatol. 2017;: pubmed publisher
    ..We previously described a new variant of endemic pemphigus foliaceus in El Bagre, Colombia (El Bagre-EPF)...
  20. Zhao H, Zhang D, Yang L, Wang E. p0071 interacts with E-cadherin in the cytoplasm so as to promote the invasion and metastasis of non-small cell lung cancer. Mol Carcinog. 2017;: pubmed publisher
    As a member of the p120-catenin (p120ctn) subfamily, the p0071 study in tumor is very limited. We demonstrated the clinicopathological significance of p0071 in non-small cell lung cancer (NSCLC), as well as E-cadherin...
  21. Hatzfeld M, Green K, Sauter H. Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains. J Cell Sci. 2003;116:1219-33 pubmed
    b>p0071, a member of the armadillo protein family, is most closely related to p120(ctn) and the plakophilins 1-3...
  22. Paffenholz R, Franke W. Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family. Differentiation. 1997;61:293-304 pubmed
    ..By aa sequence, NPRAP is highly homologous to three proteins: p120cas, p0071 and ARVCP, which represent a distinct subgroup within the plakoglobin/armadillo family...
  23. Stahl B, Diehlmann A, Sudhof T. Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071. J Biol Chem. 1999;274:9141-8 pubmed
    ..We utilized the yeast two-hybrid system to identify an interacting armadillo protein, termed p0071, that binds specifically to the hydrophilic loop of presenilin 1...
  24. Ivarsson Y, Arnold R, McLaughlin M, Nim S, Joshi R, Ray D, et al. Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes. Proc Natl Acad Sci U S A. 2014;111:2542-7 pubmed publisher
    ..The method can be extended to interrogate all potential eukaryotic, bacterial, and viral SLiMs and we suggest it will be a highly valuable approach for studying cellular and pathogen-host protein-protein interactions. ..
  25. Keil R, Hatzfeld M. The armadillo protein p0071 is involved in Rab11-dependent recycling. J Cell Sci. 2014;127:60-71 pubmed publisher
    b>p0071 is an intercellular junction protein of the p120 catenin family. We have identified Rab11a as a novel interaction partner of p0071. p0071 interacted preferentially with active Rab11a...
  26. Keil R, Kiessling C, Hatzfeld M. Targeting of p0071 to the midbody depends on KIF3. J Cell Sci. 2009;122:1174-83 pubmed publisher
    b>P0071 (plakophilin-4) is a member of the p120ctn subfamily of armadillo proteins that are essential for cell contact formation...
  27. Medvetz D, Khabibullin D, Hariharan V, Ongusaha P, Goncharova E, Schlechter T, et al. Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion. PLoS ONE. 2012;7:e47842 pubmed publisher
    ..of BHD, we discovered a physical interaction between folliculin (FLCN), the protein product of the BHD gene, and p0071, an armadillo repeat containing protein that localizes to the cytoplasm and to adherens junctions...
  28. Bonne S, van Hengel J, van Roy F. Chromosomal mapping of human armadillo genes belonging to the p120(ctn)/plakophilin subfamily. Genomics. 1998;51:452-4 pubmed
    ..plakophilin-1 (PKP1) was located at 1q32, the plakophilin-2 gene (PKP2) was located at 12p13, while the gene for p0071 was located at 2q23-q31...
  29. Keil R, Wolf A, Huttelmaier S, Hatzfeld M. Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin. Cell Cycle. 2007;6:122-7 pubmed
    P120(ctn) is the prototype of a subfamily of armadillo proteins that also comprises p0071, delta-catenin, ARVCF and the more distantly related plakophilins 1-3...
  30. Levesque G, Yu G, Nishimura M, Zhang D, Levesque L, Yu H, et al. Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin. J Neurochem. 1999;72:999-1008 pubmed
    ..of PS1 and PS2 interact specifically with three members of the armadillo protein family, including beta-catenin, p0071, and a novel neuronal-specific armadillo protein--neural plakophilin-related armadillo protein (NPRAP)...
  31. Setzer S, Calkins C, Garner J, Summers S, Green K, Kowalczyk A. Comparative analysis of armadillo family proteins in the regulation of a431 epithelial cell junction assembly, adhesion and migration. J Invest Dermatol. 2004;123:426-33 pubmed
    b>p0071 is an armadillo family protein related to both the adherens junction protein p120ctn and to the desmosomal proteins plakophilins 1-3...
  32. Laura R, Witt A, Held H, Gerstner R, Deshayes K, Koehler M, et al. The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF. J Biol Chem. 2002;277:12906-14 pubmed
    ..resembled the C-terminal PDZ domain-binding motifs of three p120-related catenins: delta-catenin, ARVCF, and p0071 (DSWV-COOH)...
  33. Nahorski M, Seabra L, Straatman Iwanowska A, Wingenfeld A, Reiman A, Lu X, et al. Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis. Hum Mol Genet. 2012;21:5268-79 pubmed publisher
    ..We identified plakophilin-4 (p0071) as a potential novel folliculin interacting protein by yeast two-hybrid analysis...
  34. Schroder R, van der Ven P, Warlo I, Schumann H, Fürst D, Blumcke I, et al. p0071, a member of the armadillo multigene family, is a constituent of sarcomeric I-bands in human skeletal muscle. J Muscle Res Cell Motil. 2000;21:577-86 pubmed
    b>p0071 is a member of the armadillo gene family that is expressed in a wide variety of mammalian tissues and cell types with a prominent cell-cell contact association in epithelial cells...