P-selectin

Summary

Gene Symbol: P-selectin
Description: selectin P (granule membrane protein 140kDa, antigen CD62)
Alias: CD62, CD62P, GMP140, GRMP, LECAM3, PADGEM, PSEL, CD62 antigen-like family member P, GMP-140, P-selectin, granule membrane protein 140, granulocyte membrane protein, leukocyte-endothelial cell adhesion molecule 3, platelet activation dependent granule-external membrane protein, platelet alpha-granule membrane protein
Species: human

Top Publications

  1. pmc Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels
    Maja Barbalic
    Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA
    Hum Mol Genet 19:1863-72. 2010
  2. ncbi Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation
    Bruce Furie
    Center for Hemostasis, Thrombosis and Vascular Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Trends Mol Med 10:171-8. 2004
  3. pmc GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies
    R P McEver
    St Francis Medical Research Institute, University of Oklahoma Health Science Center, Oklahoma City 73104
    J Clin Invest 84:92-9. 1989
  4. ncbi HIV type 1 glycoprotein 120 inhibits human B cell chemotaxis to CXC chemokine ligand (CXCL) 12, CC chemokine ligand (CCL)20, and CCL21
    Gamal Badr
    Institut National de la Sante et de la Recherche Medicale, Unité 131, Institut Paris Sud sur les Cytokines, Clamart, France
    J Immunol 175:302-10. 2005
  5. pmc Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils
    Yoshihiro Kuwano
    Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA, USA
    Blood 116:617-24. 2010
  6. doi P-selectin in placenta and gestational myometrium: its measurements and hypothetical role in hemostasis of placental bed after labor
    Mieczysław Uszyński
    Department of Propedeutics of Medicine, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Poland
    J Perinat Med 36:213-6. 2008
  7. ncbi Diminished thrombus formation and alleviation of myocardial infarction and reperfusion injury through antibody- or small-molecule-mediated inhibition of selectin-dependent platelet functions
    Gertie J Oostingh
    University of Wurzburg, Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, Wurzburg Germany
    Haematologica 92:502-12. 2007
  8. ncbi Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1
    W S Somers
    Genetics Institute, Wyeth Research, Cambridge, Massachusetts 02140, USA
    Cell 103:467-79. 2000
  9. pmc Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1
    M L Watson
    Department of Medicine, Duke University, Durham, North Carolina 27710
    J Exp Med 172:263-72. 1990
  10. ncbi Rapid upregulation of endothelial P-selectin expression via reactive oxygen species generation
    Manabu Takano
    Department of Surgery, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Am J Physiol Heart Circ Physiol 283:H2054-61. 2002

Detail Information

Publications185 found, 100 shown here

  1. pmc Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels
    Maja Barbalic
    Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA
    Hum Mol Genet 19:1863-72. 2010
    ..These results provide new insights into adhesion molecule biology...
  2. ncbi Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation
    Bruce Furie
    Center for Hemostasis, Thrombosis and Vascular Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Trends Mol Med 10:171-8. 2004
    ....
  3. pmc GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies
    R P McEver
    St Francis Medical Research Institute, University of Oklahoma Health Science Center, Oklahoma City 73104
    J Clin Invest 84:92-9. 1989
    ..The restricted expression of GMP-140 in secretory granules of platelets and endothelium suggests that it has a specific function in the vascular system rather than a general role related to inducible secretion...
  4. ncbi HIV type 1 glycoprotein 120 inhibits human B cell chemotaxis to CXC chemokine ligand (CXCL) 12, CC chemokine ligand (CCL)20, and CCL21
    Gamal Badr
    Institut National de la Sante et de la Recherche Medicale, Unité 131, Institut Paris Sud sur les Cytokines, Clamart, France
    J Immunol 175:302-10. 2005
    ..X4 and X4/R5 gp120 induced the cleavage of CD62 ligand by a mechanism dependent on matrix metalloproteinase 1 and 3, CD4, CXCR4, Galpha(i), and p38 MAPK, whereas ..
  5. pmc Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils
    Yoshihiro Kuwano
    Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA, USA
    Blood 116:617-24. 2010
    ..We conclude that human neutrophil rolling on E- or P-selectin induces the extended alpha(L)beta(2) integrin conformation through signaling triggered by PSGL-1 engagement...
  6. doi P-selectin in placenta and gestational myometrium: its measurements and hypothetical role in hemostasis of placental bed after labor
    Mieczysław Uszyński
    Department of Propedeutics of Medicine, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Poland
    J Perinat Med 36:213-6. 2008
    ..In the present study, we have asked whether P-selectin is present in placenta and myometrium and in what concentration...
  7. ncbi Diminished thrombus formation and alleviation of myocardial infarction and reperfusion injury through antibody- or small-molecule-mediated inhibition of selectin-dependent platelet functions
    Gertie J Oostingh
    University of Wurzburg, Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, Wurzburg Germany
    Haematologica 92:502-12. 2007
    ..P-selectin ctin has been implicated in important platelet functions. However, neither its role in thrombus formation and cardiovascular disorders nor its suitability as a therapeutic target structure is entirely clear...
  8. ncbi Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1
    W S Somers
    Genetics Institute, Wyeth Research, Cambridge, Massachusetts 02140, USA
    Cell 103:467-79. 2000
    ..These structures reveal differences in how E- and P-selectin bind SLe(X) and the molecular basis of the high-affinity interaction between P-selectin and PSGL-1...
  9. pmc Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1
    M L Watson
    Department of Medicine, Duke University, Durham, North Carolina 27710
    J Exp Med 172:263-72. 1990
    A structurally and functionally related group of genes, lymph node homing receptor (LHR), granule membrane protein 140 (GMP-140), and endothelial leukocyte adhesion molecule 1 (ELAM-1) are shown to constitute a gene cluster on mouse and ..
  10. ncbi Rapid upregulation of endothelial P-selectin expression via reactive oxygen species generation
    Manabu Takano
    Department of Surgery, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Am J Physiol Heart Circ Physiol 283:H2054-61. 2002
    ....
  11. ncbi Association between the Thr715Pro P-selectin gene polymorphism and soluble P-selectin levels in a multiethnic population in South London
    Michelle A Miller
    Department of Community Health Sciences, St George s Hospital Medical School, London, UK
    Thromb Haemost 92:1060-5. 2004
    ..Lower levels of sP-selectin were not accounted for by this polymorphism in blacks, in whom the C allele was very rare...
  12. pmc Evaluation of C-reactive protein, endothelin-1, adhesion molecule(s), and lipids as inflammatory markers in type 2 diabetes mellitus patients
    Hala El-Mesallamy
    Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo 11566, Egypt
    Mediators Inflamm 2007:73635. 2007
    ..P-selectin and ICAM-1 were significantly positively correlated. This study indicates that increased level of oxidative stress marker, proinflammatory markers, and their downstream effectors adhesion molecules occur in type 2 DM...
  13. doi Gastrin induces the interaction between human mononuclear leukocytes and endothelial cells through the endothelial expression of P-selectin and VCAM-1
    Sales Ibiza
    Departamento de Farmacología and CIBERehd, Universidad de Valencia, Spain
    Am J Physiol Cell Physiol 297:C1588-95. 2009
    ..Gastrin induces interactions between human mononuclear leukocytes and endothelial cells through the activation of CCK-2 receptors and the enhancement of endothelial P-selectin and VCAM-1...
  14. ncbi Polymorphisms in the P-selectin (CD62P) and P-selectin glycoprotein ligand-1 (PSGL-1) genes and coronary heart disease
    Peter Bugert
    Institute of Transfusion Medicine and Immunology, Red Cross Blood Service of Baden Württemberg Hessia, Ruprecht Karls University Heidelberg, Faculty of Clinical Medicine Mannheim, Mannheim, Germany
    Clin Chem Lab Med 42:997-1004. 2004
    ..However, the functional role of the gene variants should be elucidated by further experimental data...
  15. ncbi Polarization and interaction of adhesion molecules P-selectin glycoprotein ligand 1 and intercellular adhesion molecule 3 with moesin and ezrin in myeloid cells
    J L Alonso-Lebrero
    Servicio de Inmunologia, Hospital de la Princesa, Madrid, Spain Northwestern University Medical School, Chicago, IL, USA
    Blood 95:2413-9. 2000
    ....
  16. ncbi Identification of novel susceptibility genes in childhood-onset systemic lupus erythematosus using a uniquely designed candidate gene pathway platform
    Chaim O Jacob
    Department of Medicine, University of Southern California School of Medicine, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Arthritis Rheum 56:4164-73. 2007
    ....
  17. ncbi Quantifying the effects of molecular orientation and length on two-dimensional receptor-ligand binding kinetics
    Jun Huang
    National Microgravity Laboratory, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080, China
    J Biol Chem 279:44915-23. 2004
    ..These results demonstrate that the orientation and length of an adhesion receptor influences its rate of encountering and binding a surface ligand but does not subsequently affect the stability of binding...
  18. doi Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status
    Stylianos Bournazos
    The University of Edinburgh MRC Centre for Inflammation Research, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Arterioscler Thromb Vasc Biol 28:1491-8. 2008
    ....
  19. ncbi P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis
    Ming Chen
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate School of Chinese Academy of Sciences, Shanghai, 200031, China
    Arch Immunol Ther Exp (Warsz) 54:75-84. 2006
    Stimulated endothelial cells and activated platelets express P-selectin (CD62P), a member of the selectin family of cell adhesion molecules, which interacts with P-selectin glycoprotein ligand-1 (PSGL-1, CD162) for leukocyte rolling on ..
  20. pmc STAT-6-mediated control of P-selectin by substance P and interleukin-4 in human dermal endothelial cells
    Yasuhiro Miyazaki
    Department of Dermatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, 113 8519, Japan
    Am J Pathol 169:697-707. 2006
    ..STAT6 in dermal endothelial cells appears to be a potent target for controlling cellular infiltrate in allergic and/or neuroinflammatory skin diseases...
  21. ncbi P-selectin binding to P-selectin glycoprotein ligand-1 induces an intermediate state of alphaMbeta2 activation and acts cooperatively with extracellular stimuli to support maximal adhesion of human neutrophils
    Yan Qing Ma
    University of Minnesota Medical School, MMC 480, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Blood 104:2549-56. 2004
    ..The interaction of PSGL-1 with P-selectin (CD62P) mediates tethering, rolling, and weak adhesion of leukocytes, during which they become sufficiently activated in ..
  22. pmc Neutrophil-bead collision assay: pharmacologically induced changes in membrane mechanics regulate the PSGL-1/P-selectin adhesion lifetime
    K E Edmondson
    Institute for Medicine and Engineering, Department of Bioengineering, University of Pennsylvania, 3320 Smith Walk, Philadelphia, PA 19104, USA
    Biophys J 89:3603-14. 2005
    ..Membrane tether growth can be enhanced or reduced pharmacologically with consequent effects on PSGL-1/P-selectin lifetimes...
  23. ncbi Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation
    G I Johnston
    St Francis Medical Research Institute, University of Oklahoma Health Sciences Center, Oklahoma City
    Cell 56:1033-44. 1989
    ..This similarity suggests that GMP-140 belongs to a new family of inducible receptors with related structure and function on vascular cells...
  24. ncbi Characterization of the promoter for the human P-selectin gene
    J Pan
    W K Warren Medical Research Institute, Department of Medicine, University of Oklahoma, Health Sciences Center, Oklahoma City 73104
    J Biol Chem 268:22600-8. 1993
    ..These data suggest that the P-selectin gene is regulated by a combination of cis elements and their cognate transcription factors...
  25. ncbi Functional analysis of the combined role of the O-linked branching enzyme core 2 beta1-6-N-glucosaminyltransferase and dimerization of P-selectin glycoprotein ligand-1 in rolling on P-selectin
    McRae J Smith
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22903, USA
    J Biol Chem 279:21984-91. 2004
    ..Both C2GlcNAcT-I glycosylation and PSGL-1 dimerization increased the rate of tethering to P-selectin under flow, whereas C2GlcNAcT-I levels primarily influenced tether bond strength...
  26. ncbi Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Hum Mol Genet 13:389-96. 2004
    ..These population-based data demonstrate the ability of prospective, epidemiological studies to test candidate gene associations for athero-thrombotic disease...
  27. ncbi Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A
    Ingrid Hrachovinova
    The Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115 USA
    Nat Med 9:1020-5. 2003
    ..This significantly improved the kinetics of fibrin formation in the hemophilia A mice and normalized their tail-bleeding time. P-sel-Ig treatment could become a new approach to sustained control of bleeding in hemophilia...
  28. ncbi Structure of the human gene encoding granule membrane protein-140, a member of the selectin family of adhesion receptors for leukocytes
    G I Johnston
    Department of Medicine, St Francis Medical Research Institute, University of Oklahoma Health Sciences Center, Oklahoma City 73104
    J Biol Chem 265:21381-5. 1990
    ..The structure of the GMP-140 gene supports the concept that the selectins evolved as a result of exon duplication and rearrangement...
  29. pmc Signal-dependent distribution of cell surface P-selectin in clathrin-coated pits affects leukocyte rolling under flow
    Hendra Setiadi
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Cell Biol 163:1385-95. 2003
    ..Thus, a signaling event affects both the function and clearance of a protein that enters the constitutive clathrin-mediated endocytic pathway...
  30. ncbi Platelet P-selectin expression: requirement for protein kinase C, but not protein tyrosine kinase or phosphoinositide 3-kinase
    Danielle Libersan
    Montreal Heart Institute and the University of Montreal, Quebec, Canada
    Thromb Haemost 89:1016-23. 2003
    ..The novel epsilon and eta and atypical zeta, but not the conventional alpha and beta and the novel delta PKCs, may be involved in this process...
  31. ncbi P-selectin Thr715Pro polymorphism predicts P-selectin levels but not risk of incident coronary heart disease or ischemic stroke in a cohort of 14595 participants: the Atherosclerosis Risk in Communities Study
    Kelly A Volcik
    Human Genetics Center, University of Texas Houston Health Science Center, 1200 Herman Pressler Dr, Houston, TX 77030, USA
    Atherosclerosis 186:74-9. 2006
    ....
  32. ncbi Increased expression of platelet P-selectin and formation of platelet-leukocyte aggregates in blood from patients treated with unfractionated heparin plus eptifibatide compared with bivalirudin
    Friederike K Keating
    Cardiology Unit, Department of Medicine, University of Vermont Fletcher Allen Health Care, 111 Colchester Avenue, Burlington, VT 05401, USA
    Thromb Res 118:361-9. 2006
    ....
  33. ncbi Attachment of the PSGL-1 cytoplasmic domain to the actin cytoskeleton is essential for leukocyte rolling on P-selectin
    Karen R Snapp
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, IL 60611, USA
    Blood 99:4494-502. 2002
    ..Thus, attachment of PSGL-1 to the leukocyte cortical cytoskeleton is essential for leukocyte rolling on P-selectin...
  34. doi Pathophysiological levels of soluble P-selectin mediate adhesion of leukocytes to the endothelium through Mac-1 activation
    Kevin J Woollard
    Baker IDI Heart and Diabetes Institute, 75 Commercial Rd, Melbourne, 3004, Australia
    Circ Res 103:1128-38. 2008
    ....
  35. pmc Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin
    D J Goetz
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 137:509-19. 1997
    ..In addition, the results suggest that PSGL-1 has more than one binding site for E-selectin: one site located within the first 19 amino acids of PSGL-1 and one or more sites located between amino acids 19 through 148...
  36. ncbi Noncovalent association of P-selectin glycoprotein ligand-1 and minimal determinants for binding to P-selectin
    T K Epperson
    Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 275:7839-53. 2000
    ..These results demonstrate that Cys(320)-dependent dimerization of PSGL-1 is not required for binding to P-selectin and that a small monomeric fragment of PSGL-1 is sufficient for P-selectin recognition...
  37. ncbi Platelet-leukocyte-cross-talk in diabetes mellitus
    D Tschoepe
    Diabetes Research Institute, Heinrich Heine University of Duesseldorf, Germany
    Horm Metab Res 29:631-5. 1997
    ..as activated alpha 2 beta 3 (GPIIbIIIa), lysosomal GP53, thrombospondin or, perhaps most importantly "P-selectin" (CD62 p)...
  38. ncbi Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII
    Manuel Martinez
    Service and Central Laboratory of Hematology, Centre Hospitalier Universitaire Vaudois, Bugnon 46, 1011 Lausanne, Switzerland
    J Biol Chem 280:5378-90. 2005
    ....
  39. pmc Expression of E-selectin, P-selectin, and intercellular adhesion molecule-1 during experimental murine listeriosis
    S Lopez
    Department of Pathology, Veterinary School, Bellaterra, Barcelona, Spain
    Am J Pathol 155:1391-7. 1999
    ..Up-regulation of P-selectin and ICAM-1 during experimental murine listeriosis could play an important role in the recruitment of leukocytes, especially to the liver, lymphoid organs, and central nervous system...
  40. ncbi Cloning of the mouse endothelial selectins. Expression of both E- and P-selectin is inducible by tumor necrosis factor alpha
    A Weller
    Hans Spemann Laboratory, Max Planck Institut fur Immunbiologie, Freiburg, Germany
    J Biol Chem 267:15176-83. 1992
    E-selectin (ELAM-1) and P-selectin (GMP-140, PADGEM, CD62) have both been described as human endothelial cell adhesion molecules for neutrophils and monocytes...
  41. ncbi Platelet surface CD62P and CD63, mean platelet volume, and soluble/platelet P-selectin as indexes of platelet function in atrial fibrillation: a comparison of "healthy control subjects" and "disease control subjects" in sinus rhythm
    Anirban Choudhury
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom
    J Am Coll Cardiol 49:1957-64. 2007
    ....
  42. doi Soluble, platelet-bound, and total P-selectin as indices of platelet activation in congestive heart failure
    Irene Chung
    Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    Ann Med 41:45-51. 2009
    ..Platelets play an important role in thrombogenesis, but it is not clear whether circulating platelets actively participate in thrombosis-related complications associated with CHF...
  43. ncbi Does renal carcinoma affect the expression of P-selectin on platelets?
    M Mantur
    Department of Laboratory Diagnostics, Medical Academy of Bialystok, Poland
    Neoplasma 49:243-5. 2002
    ..P-selectin being the CD62P receptor on blood platelets was marked by anti-CD61/62P MoAb, and the results were presented as the percentage of ..
  44. ncbi Atrial fibrillation and hypercoagulability: dependent on clinical factors or/and on genetic alterations?
    Eleni Hatzinikolaou-Kotsakou
    Academic Cardiology Department, Demokritious University of Thrace, Greece
    J Thromb Thrombolysis 16:155-61. 2003
    ....
  45. ncbi Platelet, not endothelial, P-selectin is required for neointimal formation after vascular injury
    Kai Wang
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Arterioscler Thromb Vasc Biol 25:1584-9. 2005
    ..This study was designed to determine whether P-selectin expression on platelet, endothelial, or both surfaces is critical to the inflammatory response and neointimal formation after arterial injury...
  46. ncbi Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin
    S Aigner
    Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany
    Int Immunol 7:1557-65. 1995
    ..Our data suggest that HSA, in addition to the recently identified 160 kDa glycoprotein ligand on mouse neutrophils, belongs to a group of monospecific P-selectin ligands on myeloid cells...
  47. ncbi N-terminal residues in murine P-selectin glycoprotein ligand-1 required for binding to murine P-selectin
    Lijun Xia
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    Blood 101:552-9. 2003
    ..Because it uses only one tyrosine, murine PSGL-1 may rely more on other peptide components and O-glycosylation to bind to P-selectin than does human PSGL-1...
  48. ncbi Molecular characterization of equine P-selectin (CD62P) and its regulation in ovarian follicles during the ovulatory process
    Khampoune Sayasith
    Centre de recherche en reproduction animale and Département de biomédecine vétérinaire, Faculté de Médicine Vétérinaire, Universite de Montreal, Saint Hyacinthe, Quebec, Canada
    Biol Reprod 72:736-44. 2005
    ..Thus, the present study describes, to our knowledge for the first time, the primary structure of equine P-selectin and the regulation of P-selectin transcript and protein in follicular thecal endothelial cells before ovulation...
  49. doi Platelet P-selectin reflects a state of cutaneous inflammation: possible application to monitor treatment efficacy in psoriasis
    Jurate Garbaraviciene
    Department of Dermatology, Clinic of the Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Exp Dermatol 19:736-41. 2010
    ..Activated platelets expressing P-selectin (CD62P) are involved in the extravasation of leucocytes...
  50. pmc Differential regulation of human and murine P-selectin expression and function in vivo
    Zhenghui Liu
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Exp Med 207:2975-87. 2010
    ..These findings reveal functionally significant differences in basal and inducible expression of human and murine P-selectin in vivo...
  51. pmc Separation of important new platelet glycoproteins (GPIa, GPIc, GPIc*, GPIIa and GMP-140) by f.p.l.c. Characterization by monoclonal antibodies and gas-phase sequencing
    B Catimel
    INSERM unité 331, Faculté de Médecine Alexis Carrell, Lyon, France
    Biochem J 279:419-25. 1991
    ..Five minor [GPIa, GPIc, GPIc*, GPIIa and GMP 140 (PADGEM)], as well as a major (GPIIIb) glycoprotein, were eluted at low salt concentrations...
  52. ncbi Correlation between the extent of platelet activation in platelet concentrates and in vitro and in vivo parameters
    M J Dijkstra-Tiekstra
    Sanquin Blood Bank North West Region, Amsterdam, The Netherlands
    Vox Sang 87:257-63. 2004
    ....
  53. ncbi Blood platelet and monocyte activations and relation to stages of liver cirrhosis
    Anatol Panasiuk
    Department of Infectious Diseases, Medical University of Bialystok, Zurawia Str 14, 15 540 Bialystok, Poland
    World J Gastroenterol 11:2754-8. 2005
    ..In this paper, the analysis of mutual relationship between platelets and monocytes activation in LC was conducted...
  54. ncbi Inability of probiotic bacterial strains Lactobacillus rhamnosus HN001 and Bifidobacterium lactis HN019 to induce human platelet aggregation in vitro
    J S Zhou
    Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand
    J Food Prot 68:2459-64. 2005
    ..anti-CD41a (expressed on normal platelets), and phycoerythrin-streptavidin-conjugated anti-CD62p (expressed on activated platelets) before analysis by flow cytometry...
  55. ncbi Effects of epsilon-aminocaproic acid and aprotinin on leukocyte-platelet adhesion in patients undergoing cardiac surgery
    Philip E Greilich
    Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8894, USA
    Anesthesiology 100:225-33. 2004
    ..This study was performed to determine the relative effectiveness of the antifibrinolytics, aprotinin and EACA, at reducing leukocyte and platelet activation and leukocyte-platelet conjugate formation in patients undergoing CPB...
  56. ncbi Platelet activation in patients with alcoholic liver disease
    Fusao Ogasawara
    Department of Internal Medicine, Tokai University School of Medicine, Hachioji Hospital, 1838 Ishikawa machi, Hachioji, Tokyo 192 0032, Japan
    Tokai J Exp Clin Med 30:41-8. 2005
    ....
  57. ncbi Markers of endothelial and in vivo platelet activation in patients with essential thrombocythemia and polycythemia vera
    Marina Karakantza
    Laboratory Hematology and Transfusion Medicine, Medical School, University of Patras, Patras GR 26110, Greece
    Int J Hematol 79:253-9. 2004
    ..We measured platelet expression of CD62P and CD63 antigens and levels of soluble vascular cell adhesion molecule 1 (sVCAM-1)...
  58. ncbi Platelet activation in patients with obstructive sleep apnea syndrome and effects of nasal-continuous positive airway pressure
    Mie Shimizu
    Department of Laboratory Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Tokai J Exp Clin Med 27:107-12. 2002
    ....
  59. ncbi Assessment of platelet activation in several different anticoagulants by the Advia 120 Hematology System, fluorescence flow cytometry, and electron microscopy
    Charaf E Ahnadi
    Centre for Research and Evaluation in Diagnostics, Centre Hospitalier Universitaire de Sherbrooke, 3001, 12 Avenue Nord, Sherbrooke, Quebec, Canada J1H 5N4
    Thromb Haemost 90:940-8. 2003
    ..with a fluorescence flow cytometric method, also determined in this study, using the surface expression of CD62P. Moreover, platelet shape and structure changes in EDTA and CTAD anticoagulated whole blood specimens were ..
  60. ncbi Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P- and E-selectin
    F Li
    W K Warren Medical Research Institute, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, 73140, USA
    J Biol Chem 271:3255-64. 1996
    ..These results demonstrate that PSGL-1 requires core 2 O-linked glycans that are sialylated and fucosylated to bind P- and E-selectin. PSGL-1 also requires tyrosine sulfate to bind P-selectin but not E-selectin...
  61. doi Platelet activation in clinical haemodialysis: LMWH as a major contributor to bio-incompatibility?
    Mareille Gritters
    Department of Nephrology, VU University Medical Centre, PO Box 7075, 1007 MB Amsterdam, The Netherlands
    Nephrol Dial Transplant 23:2911-7. 2008
    ..Concerning platelets, both an increase in the expression of the cell surface marker P-selectin (CD62p) and release of the intracellular granule product platelet factor 4 (PF4) have been described...
  62. ncbi [Soluble adhesion molecules in female patients with breast carcinoma]
    P Tesarova
    I interní klinika 1 LF UK a VFN, Praha
    Cas Lek Cesk 142:292-9. 2003
    ..We wanted to find out if these parameters differ between various stages of breast cancer and if their levels are influenced by the therapy...
  63. ncbi In vivo platelet activation is increased during sleep in patients with obstructive sleep apnea syndrome
    Thomas Geiser
    Department of Pulmonary Medicine, University Hospital, Bern, Switzerland
    Respiration 69:229-34. 2002
    ..Patients with obstructive sleep apnea syndrome (OSAS) have an increased risk of cardiovascular events including myocardial infarction and stroke...
  64. pmc Relationship and significance between anti-beta2-glycoprotein I antibodies and platelet activation state in patients with ulcerative colitis
    Yan Hang Gao
    Department of Gastroentology, The First Affiliated Hospital, Jilin University, 71 Xinmin Street, Changchun 130021, Jilin Province, China
    World J Gastroenterol 14:771-5. 2008
    ..To study the relationship between anti-beta2-glycoprotein I (abeta2GPI) antibodies and platelet activation state in patients with ulcerative colitis (UC) and its significance...
  65. ncbi Platelet activation in acute, decompensated congestive heart failure
    Irene Chung
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, England UK
    Thromb Res 120:709-13. 2007
    ....
  66. doi [Platelet-leukocyte aggregates as a marker for platelet activation in platelet concentrates]
    T Chakroun
    Centre Regional de Transfusion Sanguine, unité de recherche étude des fonctions plaquettaires UR 06SP05, hôpital Faraht Hached, Sousse, Tunisie
    Transfus Clin Biol 15:148-53. 2008
    ..Some of them have a good correlation with the platelet recovery index. To assess the quality control of standard PC prepared in our blood bank, we measured the blood gas and the degree of platelet activation...
  67. ncbi Immunosuppressive therapy regimen and platelet activation in renal transplant patients
    Jochen Graff
    Pharmazentrum Frankfurt, Institute of Clinical Pharmacology, Funktionsbereich Nephrologie, Medizinische Klinik IV, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Clin Pharmacol Ther 72:411-8. 2002
    ..Cyclosporine (INN, ciclosporin) and azathioprine are reported to activate platelets, but data are rare and controversial for tacrolimus and mycophenolate mofetil...
  68. ncbi Platelet activation in Helicobacter pylori-associated idiopathic thrombocytopenic purpura: eradication reduces platelet activation but seldom improves platelet counts
    Eugene R Ahn
    Wallace H Coulter Platelet Laboratory, Division of Hematology Oncology, UM Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA
    Acta Haematol 116:19-24. 2006
    ..In addition, H. pylori has been shown to induce platelet activation (CD62p or P-selectin expression) in previous studies...
  69. ncbi Relationships between optical aggregometry (type born) and flow cytometry in evaluating ADP-induced platelet activation
    Silverio Sbrana
    Laboratory of Hematology and Flow Cytometry, CNR Institute of Clinical Physiology, Massa, Italy
    Cytometry B Clin Cytom 74:30-9. 2008
    ..The aim of our study has been to demonstrate the existence of relationships between early events of ADP-induced platelet activation, measured by flow cytometry and platelet-rich plasma aggregation, quantified by optical aggregometry...
  70. ncbi Early local intracoronary platelet activation after drug-eluting stent placement
    Ailiman Mahemuti
    Department of Cardiology and UPRES EA3920 IFR133, University of Franche Comte Medical School, Jean Minjoz University Hospital, Bensancon, France
    Chin Med J (Engl) 120:1986-91. 2007
    ..However, early changes in platelet activation in coronary circulation following drug-eluting stent (DES) implantation have never been reported...
  71. ncbi Neonatal platelet activation in preeclampsia
    B Klein
    Department of Obstetrics and Gynecology, University Hospital of the University of Technology, Aachen, Germany
    Clin Appl Thromb Hemost 7:29-32. 2001
    ..Antibodies against the following antigens were used as markers for platelet activation: CD 41, CD62P, CD 63, and platelet-bound fibrinogen...
  72. ncbi Platelet activation through triathlon competition in ultra-endurance trained athletes: impact of thrombin and plasmin generation and catecholamine release
    M Mockel
    Department of Medicine, Humboldt University Berlin, Germany
    Int J Sports Med 22:337-43. 2001
    ..We examined 30 healthy triathletes during a triathlon competition. Flow cytometric detection of CD62p (P-selectin) was used to measure in vivo activation of platelets...
  73. ncbi Losartan and simvastatin inhibit platelet activation in hypertensive patients
    Shosaku Nomura
    First Department of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan
    J Thromb Thrombolysis 18:177-85. 2004
    ..and platelet hyperaggregability, with increased levels of platelet activation-markers such as P-selectin (CD62P) and platelet-derived microparticles...
  74. ncbi Platelet activation in Alzheimer disease
    S Sevush
    Department of Psychiatry, University of Miami School of Medicine, Fla 33136, USA
    Arch Neurol 55:530-6. 1998
    ..In light of recent reports of diminished platelet serotonin concentration and increased plasma serotonin levels in patients with Alzheimer disease (AD), we hypothesized that a state of heightened platelet activation might be present in AD...
  75. ncbi [Effect of tetramethylpyrazine on platelet activation and vascular endothelial function in patients with acute coronary syndrome undergoing percutaneous coronary intervention]
    Zhang Qiang Chen
    Department of Cardiology, Jiangxi Provincial People s Hospital, Nanchang
    Zhongguo Zhong Xi Yi Jie He Za Zhi 27:1078-81. 2007
    ..To explore the effect of tetramethylpyrazine (TMP) on platelet activation and vascular endothelial function after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS)...
  76. ncbi Use of mean platelet component to measure platelet activation on the ADVIA 120 haematology system
    M G Macey
    Department of Haematology, The Royal London Hospital, London, United Kingdom
    Cytometry 38:250-5. 1999
    Platelet activation results in changes in a number of cell surface molecules including an increase in P-Selectin (CD62P) that may be rapidly and conveniently measured by immunofluorescent flow cytometry...
  77. doi Levels and value of platelet activation markers in different subtypes of acute non-cardio-embolic ischemic stroke
    Nai Wen Tsai
    Department of Neurology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Thromb Res 124:213-8. 2009
    ..This study aimed to evaluate the value of platelet activation and platelet-leukocyte interaction in different subtypes of acute, non-cardio-embolic ischemic stroke...
  78. ncbi Increased platelet surface expression of P-selectin and thrombospondin as markers of platelet activation in essential thrombocythaemia
    M Griesshammer
    Department of Haematology and Oncology, Infectious Diseases and Haemostaseology, University of Ulm, Federal Republic of Germany
    Thromb Res 96:191-6. 1999
    ..The platelet surface expression of p-selectin (CD62p) and thrombospondin (TSP) has been shown to correlate with platelet activation...
  79. doi Relationship between platelet activation related factors and polymorphism of related genes in patients with coronary heart disease of blood-stasis syndrome
    Mei Xue
    Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
    Chin J Integr Med 14:267-73. 2008
    ....
  80. ncbi Comparison of two methods to assess variability of platelet response to anti-platelet therapies in patients with acute coronary syndrome undergoing angioplasty
    Charaf E Ahnadi
    Collaborative Research for Effective Diagnostics, Centre Hospitalier Universitaire de Sherbrooke, 3001, 12 Avenue Nord, Sherbrooke, Quebec, Canada J1H 5N4
    Thromb Haemost 92:1207-13. 2004
    ..Concentration), on the automated ADVIA 120 Hematology System and by the classic measurement of P-selectin (CD62P) expression, on a fluorescence flow cytometer...
  81. ncbi Effects of urinary protease inhibitor on inflammatory response during on-pump coronary revascularisation. Effect of ulinastatin on inflammatory response
    J Bingyang
    Department of Cardiopulmonary Bypass, Cardiovascular Institute and Fuwai Hospital, PUMC and CAMS, Beijing, China
    J Cardiovasc Surg (Torino) 48:497-503. 2007
    ..We performed a prospective randomized study to investigate the influence of high-dose ulinastatin on cytokines and platelet activation and on respiratory function during and after CPB...
  82. doi The association of depression with platelet activation: evidence for a treatment effect
    M C Morel-Kopp
    Northern Blood Research Centre, Department of Haematology and Transfusion Medicine, University of Sydney, Sydney, NSW, Australia
    J Thromb Haemost 7:573-81. 2009
    ..Depression is associated with an increased risk of cardiovascular disease (CVD). Although the mechanism is uncertain, prothrombotic and inflammatory factors may play a role...
  83. ncbi Significance of platelet activation in vascular access survival of haemodialysis patients
    Yao Cheng Chuang
    Division of Nephrology, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung, 123 Ta Pei Road, Niaosung Hsiang, Kaohsiung Hsien, Taiwan 833, Republic of China
    Nephrol Dial Transplant 18:947-54. 2003
    ..The aim of this study was to investigate the role of platelet activation in recurrent vascular access failure...
  84. ncbi Platelets and cytokines in concert with endothelial activation in patients with peripheral arterial occlusive disease
    D A Tsakiris
    Haemostasis Laboratory DCL, University Hospital Basel, Switzerland
    Blood Coagul Fibrinolysis 11:165-73. 2000
    ..Platelet membrane activation markers (CD62P, CD63, activated GPIIb/IIIa) were immunologically measured at 0, 1, 24 and 48 h, and 3 and 6 months after PTA...
  85. doi Potential enzyme cost reduction with the addition of surfactant during the hydrolysis of pretreated softwood
    Maobing Tu
    School of Forestry and Wildlife Sciences, Auburn University, Auburn, AL 36849, USA
    Appl Biochem Biotechnol 161:274-87. 2010
    ..Further analysis indicated a 66% reduction in total enzyme cost could potentially be achieved under the concept...
  86. ncbi Circulating vascular cell adhesion molecule-1 correlates with the extent of human atherosclerosis in contrast to circulating intercellular adhesion molecule-1, E-selectin, P-selectin, and thrombomodulin
    K Peter
    Department of Cardiology, University of Heidelberg, Germany
    Arterioscler Thromb Vasc Biol 17:505-12. 1997
    ..These findings suggest an important role of VCAM-1 in atherosclerosis and may serve as the basis for further evaluation of circulating VCAM-1 as a potential serum marker for atherosclerosis...
  87. doi Monocyte-platelet complexes on CD14/CD16 monocyte subsets: relationship with ApoA-I levels. A preliminary study
    Karim Zouaoui Boudjeltia
    Laboratoire de Médecine Expérimentale ULB 222 Unit, ISPPC Hopital André Vesale, Montigny le Tilleul, Belgium
    Cardiovasc Pathol 17:285-8. 2008
    ..Studies showed the essential role of L-selectin (CD62-L), expressed by the monocytes, and the platelets by forming complexes with monocytes...
  88. ncbi [Effects of ulinastatin on coagulation and platelet function in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass]
    Hong wen Ji
    Department of Anesthesiology, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China
    Zhonghua Yi Xue Za Zhi 89:175-8. 2009
    ..To investigate the effects of ulinastatin (U) on coagulation, platelet function, and postoperative bleeding in patients undergoing coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB)...
  89. ncbi Recycling cellulases during the hydrolysis of steam exploded and ethanol pretreated Lodgepole pine
    Maobing Tu
    Forest Products Biotechnology Group, Department of Wood Science, Forest Sciences Centre, University of British Columbia, 2424 Main Mall, V6T 1Z4, Vancouver, British Columbia, Canada
    Biotechnol Prog 23:1130-7. 2007
    ..These results suggested that the higher lignin content of the SELP substrate, and the low affinity of cellulases for the SELP substrate limited enzyme recycling by readsorption onto fresh substrates...
  90. pmc Patients with acute coronary syndromes express enhanced CD40 ligand/CD154 on platelets
    C D Garlichs
    Medical Clinic II, Friedrich Alexander University Erlangen Nurnberg, Ostliche Stadmauerstrasser 29, 91054 Erlangen, Germany
    Heart 86:649-55. 2001
    ..To investigate whether CD40L/CD154 on platelets and soluble CD40L/CD154 may play a role in the inflammatory process of acute coronary syndromes...
  91. ncbi Flow cytometric quantitation of immunofluorescence intensity: problems and perspectives. European Working Group on Clinical Cell Analysis
    J W Gratama
    Department of Clinical and Tumor Immunology, Daniel den Hoed Kliniek, Rotterdam, The Netherlands
    Cytometry 33:166-78. 1998
    ..lymphoma cells, intensity of CD38 expression by CD8+ T-lymphocytes to monitor activation status, and intensity of CD62P to detect platelet activation...
  92. pmc Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1
    G S Kansas
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115 6084
    J Cell Biol 114:351-8. 1991
    ..family of cell adhesion molecules, termed selectins or LEC-CAMs, which also includes ELAM-1 and PAD-GEM (GMP-140/CD62)...
  93. ncbi Sodium nitroprusside in patients with compromised left ventricular function undergoing coronary bypass: reduction of cardiac proinflammatory substances
    P Massoudy
    Department of Cardiovascular Surgery, University of Essen, Essen, Germany
    J Thorac Cardiovasc Surg 119:566-74. 2000
    ....
  94. ncbi Differential roles of CD36, ICAM-1, and P-selectin in Plasmodium falciparum cytoadherence in vivo
    Bryan G Yipp
    Department of Microbiology and Infectious Diseases, University of Calgary, Alberta, Canada
    Microcirculation 14:593-602. 2007
    ..These findings indicate that in addition to CD36, ICAM-1, and P-selectin are major contributors to the dynamic process of IRBC adhesion by different mechanisms in vivo...
  95. ncbi Platelet activation in patients with chronic nonvalvular atrial fibrillation
    Hon Kan Yip
    Division of Cardiology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, ROC
    Int Heart J 47:371-9. 2006
    ..This study investigated platelet reactivity (expressed by CD62p) in patients with chronic nonvalvular (NV) AF...
  96. pmc Mucin 16 is a functional selectin ligand on pancreatic cancer cells
    Shih Hsun Chen
    Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA
    FASEB J 26:1349-59. 2012
    ..These findings provide a novel integrated perspective on the enhanced metastatic potential associated with MUC16 overexpression and the role of selectins in metastasis...
  97. ncbi Group B streptococcus isolates from septic patients and healthy carriers differentially activate platelet signaling cascades
    Celine Siauw
    University Children s Hospital, University of Wuerzburg, Wuerzburg, Germany
    Thromb Haemost 95:836-49. 2006
    ..fibrinogen on their surface and induced platelet thromboxane synthesis, platelet aggregation, and P-selectin (CD62P) expression...
  98. doi Selectin-mediated adhesion in shear flow using micropatterned substrates: multiple-bond interactions govern the critical length for cell binding
    Ziqiu Tong
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, 3400 N, Charles Street, Baltimore, MD 21218, USA
    Integr Biol (Camb) 4:847-56. 2012
    ..Detailed knowledge of how molecular interactions modulate macroscopic cell binding behavior pertinent to inflammation and metastasis would facilitate the development of promising diagnostic tools to combat these diseases...
  99. doi P-selectin paradox and dementia of the Alzheimer type: circulating P-selectin is increased but platelet-bound P-selectin after agonist provocation is compromised
    Petter Järemo
    Department of Internal Medicine, Vrinnevi Hospital, Norrkoping, Sweden
    Scand J Clin Lab Invest 73:170-4. 2013
    ..Upon activation, P-selectin is relocated to cell surfaces where it acts as a receptor. Subsequently, the protein is cleaved from the membrane, to then be circulated. We investigated P-selectin behavior in AD dementia...
  100. ncbi Solute diffusion in genetically engineered silk-elastinlike protein polymer hydrogels
    Adam A Dinerman
    University of Maryland School of Pharmacy, Department of Pharmaceutical Sciences, 20 N Pine Street, Baltimore, MD 21201, USA
    J Control Release 82:277-87. 2002
    ..The apparent increase in the equilibrium swelling ratio was most likely due to a decrease in the hydrogel crosslinking density following the removal of the polymer soluble fraction over the course of the release study...
  101. ncbi Different therapy for different types of ulcerative colitis in China
    Xue Liang Jiang
    Department of Gastroenterology, Chinese PLA General Hospital of Jinan Military Command, 25 Shifanlu, Jinan 250031, Shandong Province, China
    World J Gastroenterol 10:1513-20. 2004
    ..To study the different therapy for different types of ulcerative colitis (UC) in China...

Research Grants63

  1. SELECTINS ROLE IN VASCULAR INJURY IN GENE-TARGETED
    Ian Sarembock; Fiscal Year: 2004
    ..In addition, these studies will open new avenues to potential therapeutic strategies to limit neointimal growth after vascular injury. ..
  2. X-RAYS INDUCE EXOCYTOSIS OF ENDOTHELIAL P-SELECTIN
    Dennis Hallahan; Fiscal Year: 2002
    ..These proteins included CD62P (P-selectin), CD63, Interleukin-8, and von Willebrand factor (vWF)...
  3. PHTHALOCYANINE PDT--IN VIVO RESPONSES AND MECHANISMS
    Craig Elmets; Fiscal Year: 2004
    ..The long-term goal of these studies is to generate new knowledge regarding the in vivo mechanisms by which PDT works so that it can be used more effectively to treat cancer. ..
  4. Modulation of Leukocyte Adhesion by P-selectin/PSGL-1 Signaling
    Jian Guo Geng; Fiscal Year: 2009
    ..P-selectin (CD62P), P-selectin glycoprotein ligand-1 (PSGL-1, CD162) and beta2-integrins are endothelial and leukocyte cell adhesion ..
  5. Modulation of Leukocyte Adhesion by P-selectin/PSGL-1 Signaling
    Jian Guo Geng; Fiscal Year: 2007
    ..P-selectin (CD62P), P-selectin glycoprotein ligand-1 (PSGL-1, CD162) and beta2-integrins are endothelial and leukocyte cell adhesion ..
  6. Modulation of Leukocyte Adhesion by P-selectin/PSGL-1 Signaling
    Jian Guo Geng; Fiscal Year: 2010
    ..P-selectin (CD62P), P-selectin glycoprotein ligand-1 (PSGL-1, CD162) and beta2-integrins are endothelial and leukocyte cell adhesion ..
  7. MIGRATION OF PIONEER T LYMPHOCYTES INTO THE BRAIN
    Michael Carrithers; Fiscal Year: 2003
    During the first two years of this award, it was demonstrated that P selectin (CD62P) mediates migration of pioneer T lymphocytes into the central nervous system (CNS)...
  8. DISORDERED BLOOD COAGULATION IN SICKLE CELL DISEASE
    Kenneth Ataga; Fiscal Year: 2006
    ..Similarly, exposure of such surface markers as CD62P and CD40L, along with increased circulating levels of thrombospondin represents strong evidence of platelet ..
  9. NEUTROPHILS TRANSENDOTHELIAL MIGRATION: MOLECULAR EVENTS
    Alan Burns; Fiscal Year: 2004
    ..assays to examine the functional role of leukocyte (CD11a/CD18 and CD11b/CD18) and endothelial (CD31, CD54, CD62E, CD62P) adhesion molecules and chemotactic factors (IL-8, PAF, MIP-2, and KC) in neutrophil migration at tricellular ..
  10. CELL SURFACE LECTINS AND INTERCELLUAR ADHESION
    Steven Rosen; Fiscal Year: 1993
    ..newly emerging "selectin" or "LECAM" family of cell-cell adhesion proteins, which also includes ELAM-1 and GMP-140/PADGEM. As a consequence of their amino-terminal lectin domains, all of these proteins function as calcium-dependent ..
  11. Engineering Polymers For Gene Therapy of Head Cancer
    Peter Swaan; Fiscal Year: 2007
    ..In the future phases, the proposed matrix-mediated adenoviral .gene therapy approach using genetically engineered polymers can be used for the development of clinically acceptable systems for gene therapy of head and neck cancer. ..
  12. Engineering Polymers For Gene Therapy of Head Cancer
    Hamid Ghandehari; Fiscal Year: 2006
    ..In the future phases, the proposed matrix-mediated adenoviral .gene therapy approach using genetically engineered polymers can be used for the development of clinically acceptable systems for gene therapy of head and neck cancer. ..