Gene Symbol: P CIP1
Description: Ras association domain family member 9
Alias: P-CIP1, PAMCI, PCIP1, ras association domain-containing protein 9, PAM COOH-terminal interactor protein 1, Ras association (RalGDS/AF-6) domain family (N-terminal) member 9, peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor protein-1
SÃ¡nchez TomÃ© E, Rivera B, Perea J, Pita G, Rueda D, Mercadillo F, et al
. Genome-wide linkage analysis and tumoral characterization reveal heterogeneity in familial colorectal cancer type X. J Gastroenterol. 2015;50:657-66 pubmed publisher
..The remaining cases did not have alterations in any known carcinogenic pathways. Our results highlight the heterogeneity of FCCTX tumours and call into question the utility of using only clinical criteria to identify FCCTX cases. ..
Donner I, Katainen R, Kaasinen E, Aavikko M, Sipilä L, Pukkala E, et al
. Candidate susceptibility variants in angioimmunoblastic T-cell lymphoma. Fam Cancer. 2018;: pubmed publisher
..If validated, our findings would provide new insight into the pathogenesis of AITL, as well as tools for early detection in susceptible individuals. ..
Banerjee J, Aerne B, Holder M, Hauri S, Gstaiger M, Tapon N. Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division. elife. 2017;6: pubmed publisher
..Thus, Meru belongs to a class of proteins that act cell/tissue-specifically to remodel the core polarity machinery. ..
Chen L, Johnson R, Milgram S. P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes. J Biol Chem. 1998;273:33524-32 pubmed
..The data suggest that P-CIP1 associates with vesicles in the recycling endosomal pathway, and may play a role in regulating the trafficking of integral membrane PAM. ..
Sherwood V, Manbodh R, Sheppard C, Chalmers A. RASSF7 is a member of a new family of RAS association domain-containing proteins and is required for completing mitosis. Mol Biol Cell. 2008;19:1772-82 pubmed publisher
..Thus RASSF7, the first member of the N-terminal RASSF family to be functionally analyzed, is a centrosome-associated protein required to form a spindle and complete mitosis in the neural tube. ..
Kita R, Fraser H. Local Adaptation of Sun-Exposure-Dependent Gene Expression Regulation in Human Skin. PLoS Genet. 2016;12:e1006382 pubmed publisher
..These results provide the first examples of sun-exposure-dependent regulatory variation and suggest that this variation has contributed to recent human adaptation. ..
Nejadtaghi M, Jafari H, Farrokhi E, Samani K. Familial Colorectal Cancer Type X (FCCTX) and the correlation with various genes-A systematic review. Curr Probl Cancer. 2017;41:388-397 pubmed publisher
..Considering the fact that BRCA2 has the highest mutation rate (60%) and is one of the most crucial DNA repair genes, it will be considered as a big role player in this type of cancer in comparison with other genes. ..