oxytocin receptor


Gene Symbol: oxytocin receptor
Description: oxytocin receptor
Alias: OT-R, oxytocin receptor
Species: human
Products:     oxytocin receptor

Top Publications

  1. Israel S, Lerer E, Shalev I, Uzefovsky F, Riebold M, Laiba E, et al. The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task. PLoS ONE. 2009;4:e5535 pubmed publisher
    ..In the current investigation, the gene encoding the related oxytocin receptor (OXTR) was tested for association with the DG and a related paradigm, the Social Values Orientation (SVO) ..
  2. Furman D, Chen M, Gotlib I. Variant in oxytocin receptor gene is associated with amygdala volume. Psychoneuroendocrinology. 2011;36:891-7 pubmed publisher
    ..relevant genetic variants in the oxytocin system have yielded associations between polymorphisms of the oxytocin receptor (OXTR) gene and both autism and major depression...
  3. Lerer E, Levi S, Salomon S, Darvasi A, Yirmiya N, Ebstein R. Association between the oxytocin receptor (OXTR) gene and autism: relationship to Vineland Adaptive Behavior Scales and cognition. Mol Psychiatry. 2008;13:980-8 pubmed
    Evidence both from animal and human studies suggests that common polymorphisms in the oxytocin receptor (OXTR) gene are likely candidates to confer risk for autism spectrum disorders (ASD)...
  4. Kimura T, Takemura M, Nomura S, Nobunaga T, Kubota Y, Inoue T, et al. Expression of oxytocin receptor in human pregnant myometrium. Endocrinology. 1996;137:780-5 pubmed
    ..These findings indicated that the expression of OTR changes dynamically at the transcription and protein level during pregnancy and that its expression is heterogeneous in the term myometrium. ..
  5. Brune M. Does the oxytocin receptor (OXTR) polymorphism (rs2254298) confer 'vulnerability' for psychopathology or 'differential susceptibility'? Insights from evolution. BMC Med. 2012;10:38 pubmed publisher
    ..incorporating findings from behavioural and neuroanatomical studies in relation to genetic variation of the oxytocin receptor gene...
  6. Apicella C, Cesarini D, Johannesson M, Dawes C, Lichtenstein P, Wallace B, et al. No association between oxytocin receptor (OXTR) gene polymorphisms and experimentally elicited social preferences. PLoS ONE. 2010;5:e11153 pubmed publisher
    ..However, actual studies of associations between oxytocin receptor (OXTR) gene variants and experimentally elicited social preferences are rare...
  7. Malik A, Zai C, Abu Z, Nowrouzi B, Beitchman J. The role of oxytocin and oxytocin receptor gene variants in childhood-onset aggression. Genes Brain Behav. 2012;11:545-51 pubmed publisher
    ..oxytocin gene (OXT) single nucleotide polymorphisms (SNPs): rs3761248, rs4813625 and rs877172; and five oxytocin receptor gene (OXTR) SNPs: rs6770632, rs11476, rs1042778, rs237902 and rs53576...
  8. Walum H, Lichtenstein P, Neiderhiser J, Reiss D, Ganiban J, Spotts E, et al. Variation in the oxytocin receptor gene is associated with pair-bonding and social behavior. Biol Psychiatry. 2012;71:419-26 pubmed publisher
    ..Here we investigate the extent to which genetic variants in the oxytocin receptor gene (OXTR) are associated with pair-bonding and related social behaviors in humans...
  9. Johansson A, Westberg L, Sandnabba K, Jern P, Salo B, Santtila P. Associations between oxytocin receptor gene (OXTR) polymorphisms and self-reported aggressive behavior and anger: Interactions with alcohol consumption. Psychoneuroendocrinology. 2012;37:1546-56 pubmed publisher
    ..we found that the effect of alcohol on aggressive behavior was moderated by the individual's genotype on an oxytocin receptor gene (OXTR) polymorphism (Johansson et al., 2012)...

More Information


  1. Kim H, Sherman D, Sasaki J, Xu J, Chu T, Ryu C, et al. Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. Proc Natl Acad Sci U S A. 2010;107:15717-21 pubmed publisher
    ..emotional support seeking as a type of social environment, we explored the behavioral expression of oxytocin receptor polymorphism (OXTR) rs53576, a gene previously related to socio-emotional sensitivity...
  2. Kawamura Y, Liu X, Akiyama T, Shimada T, Otowa T, Sakai Y, et al. The association between oxytocin receptor gene (OXTR) polymorphisms and affective temperaments, as measured by TEMPS-A. J Affect Disord. 2010;127:31-7 pubmed publisher
    ..The objective of this study is to assess the association between oxytocin receptor gene (OXTR) polymorphisms and affective temperaments...
  3. Unternaehrer E, Luers P, Mill J, Dempster E, Meyer A, Staehli S, et al. Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF?) after acute psychosocial stress. Transl Psychiatry. 2012;2:e150 pubmed publisher
    ..DNA methylation status before and after an acute psychosocial stressor in two stress-related genes: oxytocin receptor (OXTR) and brain-derived neurotrophic factor (BDNF?)...
  4. Yrigollen C, Han S, Kochetkova A, Babitz T, Chang J, Volkmar F, et al. Genes controlling affiliative behavior as candidate genes for autism. Biol Psychiatry. 2008;63:911-6 pubmed publisher
    ..Independent replication of these findings is needed and studies of other genes associated with affiliative behaviors are indicated. ..
  5. Skuse D, Lori A, Cubells J, Lee I, Conneely K, Puura K, et al. Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills. Proc Natl Acad Sci U S A. 2014;111:1987-92 pubmed publisher
    ..A common SNP in the oxytocin receptor (rs237887) was strongly associated with recognition memory in combined probands, parents, and siblings after ..
  6. Thompson R, Parker K, Hallmayer J, Waugh C, Gotlib I. Oxytocin receptor gene polymorphism (rs2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls. Psychoneuroendocrinology. 2011;36:144-7 pubmed publisher
    ..was designed to examine the interaction of the single nucleotide polymorphism (SNP) rs2254298 within the oxytocin receptor (OXTR) gene and quality of parental environment in predicting children's psychosocial functioning...
  7. Costa B, Pini S, Gabelloni P, Abelli M, Lari L, Cardini A, et al. Oxytocin receptor polymorphisms and adult attachment style in patients with depression. Psychoneuroendocrinology. 2009;34:1506-14 pubmed publisher
    ..two single nucleotide polymorphisms (SNPs), 6930G>A (rs53576) and 9073G>A (rs2254298), within the oxytocin receptor gene (OXTR), were studied in a cohort of 185 patients with major depression (50...
  8. Rodrigues S, Saslow L, Garcia N, John O, Keltner D. Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proc Natl Acad Sci U S A. 2009;106:21437-41 pubmed publisher
    ..In this study, we tested how a polymorphism (rs53576) of the oxytocin receptor relates to two key social processes related to oxytocin: empathy and stress reactivity...
  9. Tost H, Kolachana B, Hakimi S, Lemaitre H, Verchinski B, Mattay V, et al. A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proc Natl Acad Sci U S A. 2010;107:13936-41 pubmed publisher
    ..A common variant (rs53576) in the oxytocin receptor gene (OXTR) has been implicated in social-behavioral phenotypes, such as maternal sensitivity and empathy, ..
  10. Kumsta R, Heinrichs M. Oxytocin, stress and social behavior: neurogenetics of the human oxytocin system. Curr Opin Neurobiol. 2013;23:11-6 pubmed publisher
    ..to individual differences in social behavior and cognition, with a focus on the gene coding for the oxytocin receptor (OXTR) emerging as a particularly promising candidate...
  11. Inoue T, Kimura T, Azuma C, Inazawa J, Takemura M, Kikuchi T, et al. Structural organization of the human oxytocin receptor gene. J Biol Chem. 1994;269:32451-6 pubmed
    We isolated and characterized the human oxytocin receptor gene. Southern blots indicated that the human genome has a single copy of the gene...
  12. Souza R, De Luca V, Meltzer H, Lieberman J, Kennedy J. Schizophrenia severity and clozapine treatment outcome association with oxytocinergic genes. Int J Neuropsychopharmacol. 2010;13:793-8 pubmed publisher
    ..Additional association studies in independent samples will be able evaluate whether OXT and OXTR genes are truly playing a role in the clozapine treatment outcome. ..
  13. Montag C, Brockmann E, Bayerl M, Rujescu D, Muller D, Gallinat J. Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: a case-control study. World J Biol Psychiatry. 2013;14:500-8 pubmed publisher
    ..Our findings support hypotheses about an involvement of oxytocinergic gene variants in schizophrenia vulnerability and warrant independent replication. ..
  14. Inoue H, Yamasue H, Tochigi M, Abe O, Liu X, Kawamura Y, et al. Association between the oxytocin receptor gene and amygdalar volume in healthy adults. Biol Psychiatry. 2010;68:1066-72 pubmed publisher
    Recent studies have suggested that oxytocin affects social cognition and behavior mediated by the oxytocin receptor (OXTR) in amygdala in humans as well as in experimental animals...
  15. Wu S, Jia M, Ruan Y, Liu J, Guo Y, Shuang M, et al. Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population. Biol Psychiatry. 2005;58:74-7 pubmed
    ..Animal models and linkage data from genome screens indicate that the oxytocin receptor gene (OXTR) is an excellent candidate for research concerning psychiatric disorders, particularly those ..
  16. Wermter A, Kamp Becker I, Hesse P, Schulte Körne G, Strauch K, Remschmidt H. Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high-functioning level. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:629-639 pubmed publisher
    ..The human oxytocin receptor gene (OXTR) represents a plausible candidate gene for the etiology of ASD...
  17. Lucht M, Barnow S, Sonnenfeld C, Rosenberger A, Grabe H, Schroeder W, et al. Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:860-6 pubmed publisher
    Associations of oxytocin receptor gene (OXTR) variants and autism spectrum disorders (ASD) have been reported in earlier studies; in one of the studies associations with IQ and daily living skills were found additionally...
  18. Tansey K, Brookes K, Hill M, Cochrane L, Gill M, Skuse D, et al. Oxytocin receptor (OXTR) does not play a major role in the aetiology of autism: genetic and molecular studies. Neurosci Lett. 2010;474:163-167 pubmed publisher
    ..Genetic variation at the oxytocin receptor gene (OXTR) has been reported to be associated with autism...
  19. Wu N, Li Z, Su Y. The association between oxytocin receptor gene polymorphism (OXTR) and trait empathy. J Affect Disord. 2012;138:468-72 pubmed publisher
    ..However, the effect of diverse gene locus haplotypes of oxytocin receptor gene (OXTR) on trait empathy lacks reliable evidence...
  20. Saphire Bernstein S, Way B, Kim H, Sherman D, Taylor S. Oxytocin receptor gene (OXTR) is related to psychological resources. Proc Natl Acad Sci U S A. 2011;108:15118-22 pubmed publisher
    ..Here, we report a link between the oxytocin receptor (OXTR) SNP rs53576 and psychological resources, such that carriers of the "A" allele have lower ..
  21. Liu X, Kawamura Y, Shimada T, Otowa T, Koishi S, Sugiyama T, et al. Association of the oxytocin receptor (OXTR) gene polymorphisms with autism spectrum disorder (ASD) in the Japanese population. J Hum Genet. 2010;55:137-41 pubmed publisher
    The oxytocin receptor (OXTR) gene, which is located on chromosome 3p25.3, has been implicated as a candidate gene for susceptibility of autism spectrum disorder (ASD)...
  22. Gregory S, Connelly J, Towers A, Johnson J, Biscocho D, Markunas C, et al. Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. BMC Med. 2009;7:62 pubmed publisher
    ..We also assessed oxytocin receptor (OXTR) gene expression within the temporal cortex tissue by quantitative real-time polymerase chain reaction ..
  23. Norman G, HAWKLEY L, Luhmann M, Ball A, Cole S, Berntson G, et al. Variation in the oxytocin receptor gene influences neurocardiac reactivity to social stress and HPA function: a population based study. Horm Behav. 2012;61:134-9 pubmed publisher
    ..The present study sought to explore the influence of genetic variation in the oxytocin receptor (SNP; rs53576) on autonomic and neurohormonal functioning across both resting and psychological stress ..
  24. Feldman R, Zagoory Sharon O, Weisman O, Schneiderman I, Gordon I, Maoz R, et al. Sensitive parenting is associated with plasma oxytocin and polymorphisms in the OXTR and CD38 genes. Biol Psychiatry. 2012;72:175-81 pubmed publisher
    ..Plasma OT was assayed from adults who were genotyped for oxytocin receptor (OXTR) and CD38 risk alleles associated with social dysfunctions...
  25. Chen F, Kumsta R, von Dawans B, Monakhov M, Ebstein R, Heinrichs M. Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans. Proc Natl Acad Sci U S A. 2011;108:19937-42 pubmed publisher
    ..prosocial behavior, we investigated whether a common single nucleotide polymorphism (rs53576) in the oxytocin receptor gene (OXTR) might interact with stress-protective effects of social support...
  26. Sturge Apple M, Cicchetti D, Davies P, Suor J. Differential susceptibility in spillover between interparental conflict and maternal parenting practices: evidence for OXTR and 5-HTT genes. J Fam Psychol. 2012;26:431-42 pubmed publisher
    ..interparental conflict and mothers' parenting practices were moderated by serotonin transporter (5-HTT) and oxytocin receptor (OXTR) genes...
  27. Bakermans Kranenburg M, van IJzendoorn M. Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Soc Cogn Affect Neurosci. 2008;3:128-34 pubmed publisher
    ..We examined the role of serotonin transporter (5-HTT) and oxytocin receptor (OXTR) genes in explaining differences in sensitive parenting in a community sample of 159 Caucasian, middle-..
  28. Jacob S, Brune C, Carter C, Leventhal B, Lord C, Cook E. Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism. Neurosci Lett. 2007;417:6-9 pubmed
    The oxytocin receptor gene (OXTR) has been studied in autism because of the role of oxytocin (OT) in social cognition. Linkage has also been demonstrated to the region of OXTR in a large sample...
  29. Kogan A, Saslow L, Impett E, Oveis C, Keltner D, Rodrigues Saturn S. Thin-slicing study of the oxytocin receptor (OXTR) gene and the evaluation and expression of the prosocial disposition. Proc Natl Acad Sci U S A. 2011;108:19189-92 pubmed publisher
    Individuals who are homozygous for the G allele of the rs53576 SNP of the oxytocin receptor (OXTR) gene tend to be more prosocial than carriers of the A allele...
  30. Poulin M, Holman E. Helping hands, healthy body? Oxytocin receptor gene and prosocial behavior interact to buffer the association between stress and physical health. Horm Behav. 2013;63:510-7 pubmed publisher
    ..associations between stressful events and new-onset ailments among individuals with the AA/AG genotypes of oxytocin receptor gene (OXTR) variant rs53576, but not among those with the GG genotype...
  31. Marx P, Arany A, Ronai Z, Antal P, Sasvari Szekely M. [Genetic variability of the oxytocine receptor: an in silico study]. Neuropsychopharmacol Hung. 2011;13:139-44 pubmed
    ..In silico comparative analysis of OXTR gene variants among species and individuals might serve as an important cue for predicting the functional effects of genetic variants. ..
  32. Prichard Z, Mackinnon A, Jorm A, Easteal S. AVPR1A and OXTR polymorphisms are associated with sexual and reproductive behavioral phenotypes in humans. Mutation in brief no. 981. Online. Hum Mutat. 2007;28:1150 pubmed
    ..This study is the first to report associations between AVPR1A and OXTR genetic variation with life history traits in humans. ..
  33. Cornelis M, Glymour M, Chang S, Tchetgen E, Liang L, Koenen K, et al. Oxytocin receptor (OXTR) is not associated with optimism in the Nurses' Health Study. Mol Psychiatry. 2012;17:1157-9 pubmed publisher
  34. Vargas Pinilla P, Babb P, Nunes L, Paré P, Rosa G, Felkl A, et al. Progesterone Response Element Variation in the OXTR Promoter Region and Paternal Care in New World Monkeys. Behav Genet. 2017;47:77-87 pubmed publisher
    ..We suggest that PRE number could be an essential part of the genetic repertoire that allowed the emergence of taxon-specific complex social behaviors, such as paternal care in marmosets and tamarins. ..
  35. Kaushik G, Xia Y, Pfau J, Thomas M. Dysregulation of autism-associated synaptic proteins by psychoactive pharmaceuticals at environmental concentrations. Neurosci Lett. 2017;661:143-148 pubmed publisher
  36. Pliska V, Jutz G. Kinetics of oxytocin and deaminooxytocin displacement from the OXTR-receptor compartment in rat uterus ex vivo. Biochem Pharmacol. 2018;148:278-287 pubmed publisher
    ..25 to 5 per cent of the available receptors are involved in eliciting a maximal uterus contraction. The remnant receptor pool is likely to behave as a receptor reserve ("spare receptors"). ..
  37. Richter O, Kübler K, Schmolling J, Kupka M, Reinsberg J, Ulrich U, et al. Oxytocin receptor gene expression of estrogen-stimulated human myometrium in extracorporeally perfused non-pregnant uteri. Mol Hum Reprod. 2004;10:339-46 pubmed
    Oxytocin (OT) and the oxytocin receptor (OTR) seem to be less important for uterine contractility-associated disorders of the non-pregnant uterus compared to the pregnant uterus...
  38. Wang J, BRASKIE M, Hafzalla G, Faskowitz J, McMahon K, de Zubicaray G, et al. Relationship of a common OXTR gene variant to brain structure and default mode network function in healthy humans. Neuroimage. 2017;147:500-506 pubmed publisher
    A large body of research suggests that oxytocin receptor (OXTR) gene polymorphisms may influence both social behaviors and psychiatric conditions related to social deficits, such as autism spectrum disorders (ASDs), schizophrenia, and ..
  39. Unternaehrer E, Bolten M, Nast I, Staehli S, Meyer A, Dempster E, et al. Maternal adversities during pregnancy and cord blood oxytocin receptor (OXTR) DNA methylation. Soc Cogn Affect Neurosci. 2016;11:1460-70 pubmed publisher
    ..whether maternal adversities and cortisol levels during pregnancy predict cord blood DNA methylation of the oxytocin receptor (OXTR)...
  40. Cheng Z, Abudureyimu A, Oguejiofor C, Ellis R, Barry A, Chen X, et al. BVDV alters uterine prostaglandin production during pregnancy recognition in cows. Reproduction. 2016;151:605-14 pubmed publisher
  41. Baribeau D, Dupuis A, Paton T, Scherer S, Schachar R, Arnold P, et al. Oxytocin Receptor Polymorphisms are Differentially Associated with Social Abilities across Neurodevelopmental Disorders. Sci Rep. 2017;7:11618 pubmed publisher
    ..Single nucleotide polymorphisms (SNPs) in the oxytocin receptor gene (OXTR) have been shown to explain some variability in social abilities in control populations...
  42. Wasilewska K, Pawlak A, Kostrzewa G, Sobczyk Kopcioł A, Kaczorowska A, Badowski J, et al. OXTR polymorphism in depression and completed suicide-A study on a large population sample. Psychoneuroendocrinology. 2017;77:84-89 pubmed publisher
    ..The study adds to the growing knowledge on rs53576 genotype characteristics. ..
  43. Morley Fletcher S, Zuena A, Mairesse J, Gatta E, Van Camp G, Bouwalerh H, et al. The reduction in glutamate release is predictive of cognitive and emotional alterations that are corrected by the positive modulator of AMPA receptors S 47445 in perinatal stressed rats. Neuropharmacology. 2018;135:284-296 pubmed publisher
    ..These results support the interest of glutamatergic-based therapeutic strategies to alleviate stress-related disorders. ..
  44. Garabedian M, Hansen W, McCord L, Manning M, O Brien J, Curry T. Up-regulation of oxytocin receptor expression at term is related to maternal body mass index. Am J Perinatol. 2013;30:491-7 pubmed publisher
    ..b>Oxytocin receptor and connexin-43 mRNA protein expression was quantified with real-time polymerase chain reaction and Western ..
  45. van Roekel E, Verhagen M, Engels R, Goossens L, Scholte R. Oxytocin receptor gene (OXTR) in relation to loneliness in adolescence: interactions with sex, parental support, and DRD2 and 5-HTTLPR genotypes. Psychiatr Genet. 2013;23:204-13 pubmed publisher
    ..In the present study, we focused on the oxytocin receptor gene (OXTR). Associations were examined in a longitudinal study spanning five annual waves (N=307)...
  46. Chang W, Lee I, Chen K, Chi M, Chiu N, Yao W, et al. Oxytocin receptor gene rs53576 polymorphism modulates oxytocin-dopamine interaction and neuroticism traits--a SPECT study. Psychoneuroendocrinology. 2014;47:212-20 pubmed publisher
    ..Whether the interactions are modulated by oxytocin receptor (OXTR) gene variations remains unclear...
  47. Baker M, Lindell S, Driscoll C, Zhou Z, Yuan Q, Schwandt M, et al. Early rearing history influences oxytocin receptor epigenetic regulation in rhesus macaques. Proc Natl Acad Sci U S A. 2017;114:11769-11774 pubmed publisher
    ..found decreased H3K4me3 binding at genes critical to behavioral stress response, the most robust being the oxytocin receptor gene OXTR, for which we observed a corresponding decrease in RNA expression...
  48. Leonzino M, Busnelli M, Antonucci F, Verderio C, Mazzanti M, Chini B. The Timing of the Excitatory-to-Inhibitory GABA Switch Is Regulated by the Oxytocin Receptor via KCC2. Cell Rep. 2016;15:96-103 pubmed publisher
    ..These data identify KCC2 as a key target of oxytocin in postnatal events that may be linked to pathogenesis of neurodevelopmental disorders. ..
  49. Liu Y, Conboy I. Unexpected evolutionarily conserved rapid effects of viral infection on oxytocin receptor and TGF-β/pSmad3. Skelet Muscle. 2017;7:7 pubmed publisher
    ..In this study, we evaluated the effect of control lentiviral transduction on oxytocin receptor (OXTR) expression through the ERK/MAPK pathway in mouse and human skeletal muscle cells, on myogenic ..
  50. Huetter F, Bachmann H, Reinders A, Siffert D, Stelmach P, Knop D, et al. Association of a Common Oxytocin Receptor Gene Polymorphism with Self-Reported 'Empathic Concern' in a Large Population of Healthy Volunteers. PLoS ONE. 2016;11:e0160059 pubmed publisher
    Previous research has linked genomic variations of the oxytocin receptor (OXTR) gene with individual differences in empathy...
  51. Menon R, Grund T, Zoicas I, Althammer F, Fiedler D, Biermeier V, et al. Oxytocin Signaling in the Lateral Septum Prevents Social Fear during Lactation. Curr Biol. 2018;28:1066-1078.e6 pubmed publisher
    ..Hence, LS-projecting OXT neurons suppress social fear in female mice. ..
  52. Brucker S, Frank L, Eisenbeis S, Henes M, Wallwiener D, Riess O, et al. Sequence variants in ESR1 and OXTR are associated with Mayer-Rokitansky-Küster-Hauser syndrome. Acta Obstet Gynecol Scand. 2017;96:1338-1346 pubmed publisher
    ..DNA sequence analysis of the oxytocin receptor (OXTR) and estrogen receptor-1 gene (ESR1) was performed in a group of 93 clinically well-defined patients ..
  53. Chang S, Glymour M, Rewak M, Cornelis M, Walter S, Koenen K, et al. Are genetic variations in OXTR, AVPR1A, and CD38 genes important to social integration? Results from two large U.S. cohorts. Psychoneuroendocrinology. 2014;39:257-68 pubmed publisher
    ..Further work considering genetic pathways in relation to social integration may be more fruitful if these additional factors can be more comprehensively evaluated. ..
  54. Bryant R, Hung L, Dobson Stone C, Schofield P. The association between the oxytocin receptor gene (OXTR) and hypnotizability. Psychoneuroendocrinology. 2013;38:1979-84 pubmed publisher
    ..test this proposal, 185 Caucasian individuals provided saliva samples for analysis of polymorphisms in the oxytocin receptor gene, COMT, and independently completed standardized measures of hypnotizability and absorption...
  55. Vignozzi L, Filippi S, Luconi M, Morelli A, Mancina R, Marini M, et al. Oxytocin receptor is expressed in the penis and mediates an estrogen-dependent smooth muscle contractility. Endocrinology. 2004;145:1823-34 pubmed
    ..In conclusion, these findings indicate that OT might participate in inducing postorgasmic penile flaccidity and suggest a new role for estrogens in the male: regulation of CC responsiveness to OT. ..
  56. Kimura T, Ivell R. The oxytocin receptor. Results Probl Cell Differ. 1999;26:135-68 pubmed
  57. Holmqvist Jämsen S, Johansson A, Westberg L, Santtila P, von der Pahlen B, Simberg S. Associations Between Vocal Symptoms and Genetic Variants in the Oxytocin Receptor and Arginine Vasopressin 1A Receptor Gene. J Speech Lang Hear Res. 2017;60:1843-1854 pubmed publisher
    ..As stress is regarded as a risk factor for vocal symptoms, we wanted to explore the association between the oxytocin receptor gene (OXTR) and arginine vasopressin 1A receptor gene (AVPR1A) single-nucleotide polymorphisms (SNPs) and ..
  58. Schneider Hassloff H, Straube B, Jansen A, Nuscheler B, Wemken G, Witt S, et al. Oxytocin receptor polymorphism and childhood social experiences shape adult personality, brain structure and neural correlates of mentalizing. Neuroimage. 2016;134:671-684 pubmed publisher
    ..The single nucleotid polymorphism rs53576 in the oxytocin receptor (OXTR) gene has been linked to social behavioral phenotypes...
  59. Xu Y, Ren L, Zhai S, Ran L, Hu L, Luo X, et al. OXTR and ZEB1 expression before and after progesterone dosing in pregnant women with threatened premature labor. Eur Rev Med Pharmacol Sci. 2017;21:3164-3168 pubmed
    To investigate changes in the peripheral blood mRNA levels of oxytocin receptor (OXTR) and Zinc finger E-box-binding homeobox 1 (ZEB1) before and after progesterone dosing in pregnant women with threatened premature labor...
  60. Kim S, Lee J, Kang S, Yang H, Kim S, An B. The regulation of oxytocin and oxytocin receptor in human placenta according to gestational age. J Mol Endocrinol. 2017;59:235-243 pubmed publisher
    ..These results suggest that OXT and OXTR are controlled mainly by E2 in the placenta via ESR1 and thus may play physiological functions in the human placenta during the late stage of pregnancy. ..
  61. Persson M, Trottier A, Bélteky J, Roth L, Jensen P. Intranasal oxytocin and a polymorphism in the oxytocin receptor gene are associated with human-directed social behavior in golden retriever dogs. Horm Behav. 2017;95:85-93 pubmed publisher
    ..Genomic differences in the region surrounding the oxytocin receptor (OXTR) gene have previously been associated with variation in dogs' communicative skills...
  62. Schaschl H, Huber S, Schaefer K, Windhager S, Wallner B, Fieder M. Signatures of positive selection in the cis-regulatory sequences of the human oxytocin receptor (OXTR) and arginine vasopressin receptor 1a (AVPR1A) genes. BMC Evol Biol. 2015;15:85 pubmed publisher
    ..The effects of these two peptides are meditated by their specific receptors, which are encoded by the oxytocin receptor (OXTR) and arginine vasopressin receptor 1a genes (AVPR1A), respectively...
  63. Vignozzi L, Vannelli G, Morelli A, Mancina R, Marini M, Ferruzzi P, et al. Identification, characterization and biological activity of oxytocin receptor in the developing human penis. Mol Hum Reprod. 2005;11:99-106 pubmed
    ..We report here the expression of the oxytocin receptor (OTR) gene by real-time RT-PCR in human fetal tissues (11th-12th week of gestation), including the MEG...
  64. Kimura T, Makino Y, Bathgate R, Ivell R, Nobunaga T, Kubota Y, et al. The role of N-terminal glycosylation in the human oxytocin receptor. Mol Hum Reprod. 1997;3:957-63 pubmed
    The human oxytocin receptor includes three N-glycosylation sites in its extracellular N-terminal domain. We have established permanent cell-lines in which the gene for the human oxytocin receptor (OTR) has been introduced into HeLa cells...
  65. Marusak H, Furman D, Kuruvadi N, Shattuck D, Joshi S, Joshi A, et al. Amygdala responses to salient social cues vary with oxytocin receptor genotype in youth. Neuropsychologia. 2015;79:1-9 pubmed publisher
    ..The present study examines the impact of a common functional variant within the oxytocin receptor (OXTR) gene (rs2254298) on structure and function of the amygdala in a high-risk sample of urban, low-income,..
  66. Simmons C, Clancy T, Quan R, Knoll J. The oxytocin receptor gene (OXTR) localizes to human chromosome 3p25 by fluorescence in situ hybridization and PCR analysis of somatic cell hybrids. Genomics. 1995;26:623-5 pubmed
  67. Davis C, Patte K, Zai C, Kennedy J. Polymorphisms of the oxytocin receptor gene and overeating: the intermediary role of endophenotypic risk factors. Nutr Diabetes. 2017;7:e279 pubmed publisher
    ..The objectives of this study were to investigate links between polymorphisms of the oxytocin receptor (OXTR) gene and overeating, and to examine OXTR links with relevant endophenotypes of overeating related to ..
  68. Butovskaya P, Lazebny O, Sukhodolskaya E, Vasiliev V, Dronova D, Fedenok J, et al. Polymorphisms of two loci at the oxytocin receptor gene in populations of Africa, Asia and South Europe. BMC Genet. 2016;17:17 pubmed publisher
    ..The goal of this study was to estimate the gender and population differences in polymorphisms of two oxytocin receptor gene SNPs, rs53576 and rs2254298, in four populations...
  69. Isgett S, ALGOE S, Boulton A, Way B, Fredrickson B. Common variant in OXTR predicts growth in positive emotions from loving-kindness training. Psychoneuroendocrinology. 2016;73:244-251 pubmed publisher
    ..These findings are among the first to show how genetic differences in oxytocin signaling may influence an individual's capacity to experience positive emotions as a result of a socially-focused intervention. ..
  70. Saito Y, Suga M, Tochigi M, Abe O, Yahata N, Kawakubo Y, et al. Neural correlate of autistic-like traits and a common allele in the oxytocin receptor gene. Soc Cogn Affect Neurosci. 2014;9:1443-50 pubmed publisher
    ..Here, we have examined the neuroanatomical basis of ALTs and their association with the oxytocin receptor gene (OXTR) rs2254298A, a known risk allele for autism in Asian populations which has also been implicated ..
  71. Notzon S, Domschke K, Holitschke K, Ziegler C, Arolt V, Pauli P, et al. Attachment style and oxytocin receptor gene variation interact in influencing social anxiety. World J Biol Psychiatry. 2016;17:76-83 pubmed publisher
    ..interaction approach, in the present pilot study the main and interactive effects of attachment styles and oxytocin receptor (OXTR) gene variation were probed in a combined risk factor model of social anxiety in healthy probands...
  72. Munk A, Hermann A, El Shazly J, Grant P, Hennig J. The Idea Is Good, but…: Failure to Replicate Associations of Oxytocinergic Polymorphisms with Face-Inversion in the N170. PLoS ONE. 2016;11:e0151991 pubmed publisher
    ..Results, furthermore, support the hypotheses that success of reproducibility is correlated with strength of lower original p-values and larger effect sizes in the original study. ..