oxygen regulated protein


Gene Symbol: oxygen regulated protein
Description: hypoxia up-regulated 1
Alias: GRP-170, Grp170, HSP12A, ORP-150, ORP150, hypoxia up-regulated protein 1, 150 kDa oxygen-regulated protein, 170 kDa glucose-regulated protein, oxygen regulated protein (150kD)
Species: human
Products:     oxygen regulated protein

Top Publications

  1. Tamatani M, Matsuyama T, Yamaguchi A, Mitsuda N, Tsukamoto Y, Taniguchi M, et al. ORP150 protects against hypoxia/ischemia-induced neuronal death. Nat Med. 2001;7:317-23 pubmed
    Oxygen-regulated protein 150 kD (ORP150) is a novel endoplasmic-reticulum-associated chaperone induced by hypoxia/ischemia...
  2. Šrámková V, Koc M, Krauzová E, Kračmerová J, Siklová M, Elkalaf M, et al. Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression. J Physiol Biochem. 2019;: pubmed publisher
    ..Thus, a reduced lipogenic capacity of adipocytes in aged SAT appears to be linked to mitochondrial dysfunction rather than to ER stress or accumulation of senescent cells. ..
  3. Muñiz González A, Martínez Guitarte J. Effects of single exposure and binary mixtures of ultraviolet filters octocrylene and 2-ethylhexyl 4-(dimethylamino) benzoate on gene expression in the freshwater insect Chironomus riparius. Environ Sci Pollut Res Int. 2018;25:35501-35514 pubmed publisher
    ..Finally, new genes are identified in this organism, opening the possibility to analyze new cellular pathways as targets of toxicants. ..
  4. Chinen J, Cowan M. Advances and highlights in primary immunodeficiencies in 2017. J Allergy Clin Immunol. 2018;142:1041-1051 pubmed publisher
    ..The remarkable progress in the understanding and management of PIDDs reflects the current interest in this area and continues to improve the care of immunodeficient patients. ..
  5. Boussadia Z, Lamberti J, Mattei F, Pizzi E, Puglisi R, Zanetti C, et al. Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules. J Exp Clin Cancer Res. 2018;37:245 pubmed publisher
    ..Such exosomes are endowed with pro-invasive molecules of clinical relevance, which may provide a signature of melanoma advancement. ..
  6. de Oliveira K, Garlet G, De Rossi A, Barreiros D, Queiroz A, da Silva L, et al. Effects of Rosiglitazone on the Outcome of Experimental Periapical Lesions in Mice. J Endod. 2017;43:2061-2069 pubmed publisher
    ..Moreover, there were no statistically significant differences in RANKL and Dmp1 expression or in the BMD of femurs. Rosiglitazone stimulated apoptosis of osteocytes, interfering in the progression of periapical lesions in mice. ..
  7. Cox L, Vanderwall D, Parkinson K, Sweat A, Isom S. Expression profiles of select genes in cumulus-oocyte complexes from young and aged mares. Reprod Fertil Dev. 2015;27:914-24 pubmed publisher
    ..The results of the present study confirm there are age-related differences in gene expression in equine COCs, which may be associated with the lower quality and decreased developmental competence of oocytes from aged mares. ..
  8. Wang Z, Xiong F, Xie X, Chen D, Pan J, Cheng L. Astragaloside IV attenuates proteinuria in streptozotocin-induced diabetic nephropathy via the inhibition of endoplasmic reticulum stress. BMC Nephrol. 2015;16:44 pubmed publisher
    ..The expression of glucose-regulated protein 78 (GRP78) and 150 kDa oxygen-regulated protein (ORP150) mRNA and protein was determined by real-time PCR and western blotting respectively...
  9. Pagare P, Wang H, Wang X, Zhang Y. Understanding the role of glucose regulated protein 170 (GRP170) as a nucleotide exchange factor through molecular simulations. J Mol Graph Model. 2018;85:160-170 pubmed publisher
    Glucose Regulated Protein 170 (GRP170), also called Oxygen Regulated Protein 150 (ORP150), is a major molecular chaperone resident in the endoplasmic reticulum (ER)...

More Information


  1. Behnke J, Feige M, Hendershot L. BiP and its nucleotide exchange factors Grp170 and Sil1: mechanisms of action and biological functions. J Mol Biol. 2015;427:1589-608 pubmed publisher
    ..cycle of BiP in the unique environment of the ER and how it is regulated by the nucleotide exchange factors, Grp170 (glucose-regulated protein of 170kDa) and Sil1, both of which perform unanticipated roles in various biological ..
  2. Jung T, Park H, Choi G, Kim D, Ahn S, Kim D, et al. Maresin 1 attenuates pro-inflammatory reactions and ER stress in HUVECs via PPARα-mediated pathway. Mol Cell Biochem. 2018;448:335-347 pubmed publisher
    ..MAR1 also led to a dose-dependent increase in oxygen-regulated protein 150 (ORP150) expression which is responsible for the inhibition of ER stress...
  3. Berard A, Coombs K, Severini A. Quantification of the host response proteome after herpes simplex virus type 1 infection. J Proteome Res. 2015;14:2121-42 pubmed publisher
  4. Mitra T, Mahanty A, Ganguly S, Purohit G, Mohanty S, Parida P, et al. Expression patterns of heat shock protein genes in Rita rita from natural riverine habitat as biomarker response against environmental pollution. Chemosphere. 2018;211:535-546 pubmed publisher
  5. Bracher A, Verghese J. GrpE, Hsp110/Grp170, HspBP1/Sil1 and BAG domain proteins: nucleotide exchange factors for Hsp70 molecular chaperones. Subcell Biochem. 2015;78:1-33 pubmed publisher
    ..Here we review recent advances towards structure and function of nucleotide exchange factors from the Hsp110/Grp170, HspBP1/Sil1 and BAG domain protein families and discuss how these cochaperones connect protein folding with ..
  6. Labisch T, Buchkremer S, Phan V, Kollipara L, Gatz C, LENTZ C, et al. Tracking Effects of SIL1 Increase: Taking a Closer Look Beyond the Consequences of Elevated Expression Level. Mol Neurobiol. 2018;55:2524-2546 pubmed publisher
    ..However, our results also suggest that protective levels are achieved by the secretion of excessive SIL1 and GRP170 and that moderately increased SIL1 also ameliorates cellular fitness under stress conditions...
  7. Krętowski R, Borzym Kluczyk M, Stypułkowska A, Branska Januszewska J, Ostrowska H, Cechowska Pasko M. Low glucose dependent decrease of apoptosis and induction of autophagy in breast cancer MCF-7 cells. Mol Cell Biochem. 2016;417:35-47 pubmed publisher
    ..We suggest, that the antiapoptotic chaperone ORP150 induction, transcription factor NF-?B2 activation, and increased autophagy constitute mechanisms protecting the ..
  8. Wilson R, Golub S, Rowley L, Angelucci C, Karpievitch Y, Bateman J, et al. Novel Elements of the Chondrocyte Stress Response Identified Using an in Vitro Model of Mouse Cartilage Degradation. J Proteome Res. 2016;15:1033-50 pubmed publisher
    ..This first proteome-level view of the cartilage IL-1α response identified candidate biomarkers of cartilage destruction and novel targets for therapeutic intervention in osteoarthritis. ..
  9. Jung T, Kyung E, Kim H, Shin Y, Lee S, Park E, et al. Protectin DX Ameliorates Hepatic Steatosis by Suppression of Endoplasmic Reticulum Stress via AMPK-Induced ORP150 Expression. J Pharmacol Exp Ther. 2018;365:485-493 pubmed publisher
    ..the AMP-activated protein kinase (AMPK) phosphorylation, thereby upregulating oxygen-regulated protein 150 (ORP150) expression in a dose-dependent manner...
  10. Liu C, Zhong W, He Y, Li X, Li S, He K. Genome-wide analysis of tunicamycin-induced endoplasmic reticulum stress response and the protective effect of endoplasmic reticulum inhibitors in neonatal rat cardiomyocytes. Mol Cell Biochem. 2016;413:57-67 pubmed publisher
    ..Most genes altered by PP1-12 are in the category of response to ER stress (3 h) and cell cycle (24 h). Our findings help elucidate the mechanism for TM treatment and may be useful for future drug screens involved in ER stress. ..
  11. Xu Y, Wang J, Pan T, Chen X, Xu X, Jiang D, et al. Role of the ER stress in prostaglandin E2/E-prostanoid 2 receptor involved TGF-β1-induced mice mesangial cell injury. Mol Cell Biochem. 2016;411:43-55 pubmed publisher
    ..Immunohistochemical analysis showed significant augment of TRPC4 and ORP150 in the kidney of EP2(-/-) mice compared with WT mice...
  12. Behnke J, Mann M, Scruggs F, Feige M, Hendershot L. Members of the Hsp70 Family Recognize Distinct Types of Sequences to Execute ER Quality Control. Mol Cell. 2016;63:739-52 pubmed publisher
    ..We developed an in vivo peptide library covering substrates of the ER Hsp70 system: BiP, Grp170, and three of BiP's DnaJ-family co-factors (ERdj3, ERdj4, and ERdj5)...
  13. Cianciaruso C, Phelps E, Pasquier M, Hamelin R, Demurtas D, Alibashe Ahmed M, et al. Primary Human and Rat ?-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity. Diabetes. 2017;66:460-473 pubmed publisher
    ..exosome secretion by ?-cells; induced exosomal release of the immunostimulatory chaperones calreticulin, Gp96, and ORP150; and increased exosomal stimulation of antigen-presenting cells...
  14. Sepehrimanesh M, Kazemipour N, Saeb M, Nazifi S, Davis D. Proteomic analysis of continuous 900-MHz radiofrequency electromagnetic field exposure in testicular tissue: a rat model of human cell phone exposure. Environ Sci Pollut Res Int. 2017;24:13666-13673 pubmed publisher
    ..In light of the widespread practice of men carrying phones in their pockets near their gonads, where exposures can exceed as-tested guidelines, further study of these effects should be a high priority. ..
  15. Zuo D, Subjeck J, Wang X. Unfolding the Role of Large Heat Shock Proteins: New Insights and Therapeutic Implications. Front Immunol. 2016;7:75 pubmed publisher
    ..Despite their relative abundance, the large HSPs, i.e., Hsp110 and glucose-regulated protein 170 (Grp170), have received less attention compared to other conventional HSPs...
  16. Ahmadinejad F, Geir Møller S, Hashemzadeh Chaleshtori M, Bidkhori G, Jami M. Molecular Mechanisms behind Free Radical Scavengers Function against Oxidative Stress. Antioxidants (Basel). 2017;6: pubmed publisher
    ..Exposure to L-DOPA may result in hypoxia condition and further induction of ORP150 (150-kDa oxygen-regulated protein) with its concomitant cytoprotective effects but Edaravone seems to protect ..
  17. Kemter E, Frohlich T, Arnold G, Wolf E, Wanke R. Mitochondrial Dysregulation Secondary to Endoplasmic Reticulum Stress in Autosomal Dominant Tubulointerstitial Kidney Disease - UMOD (ADTKD-UMOD). Sci Rep. 2017;7:42970 pubmed publisher
    ..In conclusion, our study revealed secondary mitochondrial dysfunction in ADTKD-UMOD. ..
  18. Kezuka D, Tkarada Iemata M, Hattori T, Mori K, Takahashi R, Kitao Y, et al. Deletion of Atf6α enhances kainate-induced neuronal death in mice. Neurochem Int. 2016;92:67-74 pubmed publisher
    ..We previously reported that the 150-kDa oxygen-regulated protein (ORP150), a molecular chaperone in the endoplasmic reticulum (ER), inhibited the L-glutamate-induced neuronal death, at ..
  19. Zhang G, Storey J, Storey K. Elevated chaperone proteins are a feature of winter freeze avoidance by larvae of the goldenrod gall moth, Epiblema scudderiana. J Insect Physiol. 2018;106:106-113 pubmed publisher
    ..heat shock proteins (HSPs: Hsp110, Hsp70, Hsp60, Hsp40), three glucose-regulated proteins (GRPs: Grp78, Grp 94, Grp170) and the tailless complex polypeptide 1 (TCP-1) as well as the heat shock transcription factor (HSF1) were ..
  20. Zhang J, Yan B, Späth S, Qun H, Cornelius S, Guan D, et al. Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer. Cell Biosci. 2015;5:53 pubmed publisher
    ..Further, our study revealed significant transcriptional regulatory mechanisms, networks and gene signatures, underlying CRC malignant progression and phenotype warranting future clinical investigations. ..
  21. Bracher A, Verghese J. The nucleotide exchange factors of Hsp70 molecular chaperones. Front Mol Biosci. 2015;2:10 pubmed publisher
    ..These NEFs belong to the Hsp110/Grp170, HspBP1/Sil1, and BAG domain protein families...
  22. Yuan B, Shen H, Su T, Lin L, Chen T, Yang Z. A novel nanoparticle containing neuritin peptide with grp170 induces a CTL response to inhibit tumor growth. J Neurooncol. 2015;125:23-32 pubmed publisher
    ..In this study, we constructed a novel nanoparticle containing neuritin peptide with grp170. The nanoparticle could elicit a neuritin-specific cytotoxic T lymphocyte response to lyse glioma cells in vitro...
  23. Khoo C, Roubelakis M, Schrader J, Tsaknakis G, Konietzny R, Kessler B, et al. miR-193a-3p interaction with HMGB1 downregulates human endothelial cell proliferation and migration. Sci Rep. 2017;7:44137 pubmed publisher
  24. Gorasia D, Dudek N, Safavi Hemami H, Perez R, Schittenhelm R, Saunders P, et al. A prominent role of PDIA6 in processing of misfolded proinsulin. Biochim Biophys Acta. 2016;1864:715-723 pubmed publisher
    ..Several chaperones (including BiP, PDIA6, calnexin, calreticulin, GRP170, Erdj3 and ribophorin II) co-immunoprecipitated with proinsulin suggesting a role for these proteins in folding...
  25. Krętowski R, Stypułkowska A, Cechowska Pasko M. Low-glucose medium induces ORP150 expression and exerts inhibitory effect on apoptosis and senescence of human breast MCF7 cells. Acta Biochim Pol. 2013;60:167-73 pubmed
    ..evoking endoplasmic reticulum (ER) stress and induction of expression of an oxygen-regulated protein of 150 kDa (ORP150)...
  26. Takeuchi S. Molecular cloning, sequence, function and structural basis of human heart 150 kDa oxygen-regulated protein, an ER chaperone. Protein J. 2006;25:517-28 pubmed
    ..The full-length coding sequence of 3301 bp including cDNA(s) of the ER chaperone ORP150, which was specifically induced by hypoxia stress, was cloned from human cardiac infarct...
  27. Zong Z, Du Z, Zhang H, Li C, An M, Li S, et al. Involvement of Nrf2 in proteasome inhibition-mediated induction of ORP150 in thyroid cancer cells. Oncotarget. 2016;7:3416-26 pubmed publisher
    Oxygen-regulated protein 150 (ORP150) is an inducible ER chaperone by numerous cellular insults and sustains cellular viability...
  28. Kaneda S, Yura T, Yanagi H. Production of three distinct mRNAs of 150 kDa oxygen-regulated protein (ORP150) by alternative promoters: preferential induction of one species under stress conditions. J Biochem. 2000;128:529-38 pubmed
    150 kDa oxygen-regulated protein (ORP150) is one of the endoplasmic reticulum (ER)-resident stress proteins. We have cloned and sequenced the entire human ORP150 gene covering over 15-kb...
  29. Kutomi G, Tamura Y, Okuya K, Yamamoto T, Hirohashi Y, Kamiguchi K, et al. Targeting to static endosome is required for efficient cross-presentation of endoplasmic reticulum-resident oxygen-regulated protein 150-peptide complexes. J Immunol. 2009;183:5861-9 pubmed publisher
    ..Oxygen-regulated protein 150 (ORP150), also known as grp170, is an endoplasmic reticulum-resident HSP and is up-regulated by hypoxia...
  30. Riezzo I, Neri M, De Stefano F, Fulcheri E, Ventura F, Pomara C, et al. The timing of perinatal hypoxia/ischemia events in term neonates: a retrospective autopsy study. HSPs, ORP-150 and COX2 are reliable markers to classify acute, perinatal events. Diagn Pathol. 2010;5:49 pubmed publisher
    ..HSP90 exhibited a similar pattern of positivity as HSP70. In acute group, ORP150 expressed an intense reaction showing a granular pattern in the cytoplasm of the neurons in the cortex of the ..
  31. Cechowska Pasko M, Bankowski E, Chene P. The effect of hypoxia on the expression of 150 kDa oxygen-regulated protein (ORP 150) in HeLa cells. Cell Physiol Biochem. 2006;17:89-96 pubmed
    ..These bind to unfolded / misfolded proteins to facilitate correct assembly. ORP 150 is the subject of this study...
  32. Abu El Asrar A, Ahmad A, Alam K, Bittoun E, Siddiquei M, Mohammad G, et al. Association of 150-kDa oxygen-regulated protein with vascular endothelial growth factor in proliferative diabetic retinopathy. Acta Ophthalmol. 2017;: pubmed publisher
    150-kDa oxygen-regulated protein (ORP150), a member of heat-shock protein family located in endoplasmic reticulum (ER), has a critical role in secretion of vascular endothelial growth factor (VEGF)...
  33. Montesi M, Jahn K, Bonewald L, Stea S, Bordini B, Beraudi A. Hypoxia mediates osteocyte ORP150 expression and cell death in vitro. Mol Med Rep. 2016;14:4248-4254 pubmed publisher
    ..Oxygen?regulated protein 150 (ORP150) is an endoplasmic reticulum?associated chaperone that has been observed to serve an important role in the ..
  34. Inoue T, Tsai B. The Grp170 nucleotide exchange factor executes a key role during ERAD of cellular misfolded clients. Mol Biol Cell. 2016;27:1650-62 pubmed publisher
    ..Here we demonstrate that the ER-resident nucleotide exchange factor (NEF) Grp170 plays an important role during ERAD of the misfolded glycosylated client null Hong Kong (NHK)...
  35. Bando Y, Ogawa S, Yamauchi A, Kuwabara K, Ozawa K, Hori O, et al. 150-kDa oxygen-regulated protein (ORP150) functions as a novel molecular chaperone in MDCK cells. Am J Physiol Cell Physiol. 2000;278:C1172-82 pubmed
    To assess the participation of the 150-kDa oxygen-regulated protein (ORP150) in protein transport, its function in Madin-Darby canine kidney (MDCK) cells was studied...
  36. Ikeda J, Kaneda S, Kuwabara K, Ogawa S, Kobayashi T, Matsumoto M, et al. Cloning and expression of cDNA encoding the human 150 kDa oxygen-regulated protein, ORP150. Biochem Biophys Res Commun. 1997;230:94-9 pubmed
    We have cloned a cDNA encoding the human 150 kDa oxygen-regulated protein (ORP150) from hypoxia-treated astrocytoma U373 cDNA library...
  37. Li N, Zoubeidi A, Beraldi E, Gleave M. GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer. Oncogene. 2013;32:1933-42 pubmed publisher
  38. Buck T, Plavchak L, Roy A, Donnelly B, Kashlan O, Kleyman T, et al. The Lhs1/GRP170 chaperones facilitate the endoplasmic reticulum-associated degradation of the epithelial sodium channel. J Biol Chem. 2013;288:18366-80 pubmed publisher
    ..Moreover, a complex containing the mammalian Lhs1 homolog GRP170 and ?ENaC co-precipitated, and GRP170 also facilitated ENaC degradation in human, HEK293 cells, and in a Xenopus ..
  39. Liu J, Zhang L, Yao J, Yao S, Yuan T. AMPK alleviates endoplasmic reticulum stress by inducing the ER-chaperone ORP150 via FOXO1 to protect human bronchial cells from apoptosis. Biochem Biophys Res Commun. 2018;497:564-570 pubmed publisher
    ..cell protection against ER stress-induced apoptosis by upregulating the 150 kDa oxygen-regulated protein (ORP150), which functions as an ER-associated chaperone, with concomitant elevation of FOXO1, a critical transcription ..
  40. Behnke J, Hendershot L. The large Hsp70 Grp170 binds to unfolded protein substrates in vivo with a regulation distinct from conventional Hsp70s. J Biol Chem. 2014;289:2899-907 pubmed publisher
    ..The ER also possesses a single large Hsp70, the glucose-regulated protein of 170 kDa (Grp170). Like BiP it is an essential protein, but its cellular functions are not well understood...
  41. Sanson M, Auge N, Vindis C, Muller C, Bando Y, Thiers J, et al. Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression. Circ Res. 2009;104:328-36 pubmed publisher
    ..We aimed to investigate whether ER stress is induced by oxLDLs and can be prevented by the ER-associated chaperone ORP150 (150-kDa oxygen-regulated protein)...
  42. Masumu M, Hata R. Recent advances in adenovirus-mediated gene therapy for cerebral ischemia. Curr Gene Ther. 2003;3:43-8 pubmed
    ..cell line-derived neurotrophic factor (GDNF), sensitive to apoptosis gene (SAG), 150-kDa oxygen-regulated protein (ORP150), etc...
  43. Tsukamoto Y, Kuwabara K, Hirota S, Ikeda J, Stern D, Yanagi H, et al. 150-kD oxygen-regulated protein is expressed in human atherosclerotic plaques and allows mononuclear phagocytes to withstand cellular stress on exposure to hypoxia and modified low density lipoprotein. J Clin Invest. 1996;98:1930-41 pubmed
    The 150-kD oxygen-regulated protein (ORP150) was initially characterized based on its selective expression in astrocytes subjected to oxygen deprivation (Kuwabara, K., M. Matsumoto, J. Ikeda, O. Hori, S. Ogawa, Y. Maeda, K. Kitagawa, N...
  44. Tomiyama R, Takakura K, Takatou S, Le T, Nishiuchi T, Nakamura Y, et al. 3,4-dihydroxybenzalacetone and caffeic acid phenethyl ester induce preconditioning ER stress and autophagy in SH-SY5Y cells. J Cell Physiol. 2018;233:1671-1684 pubmed publisher
    ..These results suggest that DBL and CAPE induce oxidized protein-mediated ER stress and autophagy that may have a preconditioning effect in SH-SY5Y cells. ..
  45. Giffin L, Yan F, Ben Major M, Damania B. Modulation of Kaposi's sarcoma-associated herpesvirus interleukin-6 function by hypoxia-upregulated protein 1. J Virol. 2014;88:9429-41 pubmed publisher
    ..Our data suggest that HYOU1 facilitates the vIL-6-induced signaling, migration, and survival of endothelial cells. ..
  46. Kuznetsov G, Chen L, Nigam S. Multiple molecular chaperones complex with misfolded large oligomeric glycoproteins in the endoplasmic reticulum. J Biol Chem. 1997;272:3057-63 pubmed
    ..By coimmunoprecipitation in rat thyroid cells, we were able to demonstrate that BiP, grp94, ERp72, and grp170, four proteins believed to function as specific molecular chaperones, complex with Tg during its maturation...
  47. Ozawa K, Kuwabara K, Tamatani M, Takatsuji K, Tsukamoto Y, Kaneda S, et al. 150-kDa oxygen-regulated protein (ORP150) suppresses hypoxia-induced apoptotic cell death. J Biol Chem. 1999;274:6397-404 pubmed
    To determine the contribution of 150-kDa oxygen-regulated protein (ORP150) to cellular processes underlying adaptation to hypoxia, a cell line stably transfected to overexpress ORP150 antisense RNA was created...
  48. Guo C, Subjeck J, Wang X. Creation of Recombinant Chaperone Vaccine Using Large Heat Shock Protein for Antigen-Targeted Cancer Immunotherapy. Methods Mol Biol. 2018;1709:345-357 pubmed publisher
    Large heat shock proteins (HSPs) or stress proteins, including Hsp110 and Grp170, are unique molecular chaperones with superior capability of shuttling tumor protein antigens into professional antigen-presenting cells, such as dendritic ..
  49. Bando Y, Tsukamoto Y, Katayama T, Ozawa K, Kitao Y, Hori O, et al. ORP150/HSP12A protects renal tubular epithelium from ischemia-induced cell death. FASEB J. 2004;18:1401-3 pubmed
    The 150 kDa oxygen-regulated protein (ORP150) is an inducible endoplasmic reticulum (ER) chaperone with cytoprotective properties in settings of cell stress, such as ischemia/reperfusion (I/R)...
  50. Cunningham C, He K, Arunagiri A, Paton A, Paton J, Arvan P, et al. Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion. Diabetes. 2017;66:741-753 pubmed publisher
    ..We now find that the ER chaperone Grp170 participates in the degradation process by shifting Akita proinsulin from high-molecular weight (MW) ..
  51. Buck T, Jordahl A, Yates M, Preston G, Cook E, Kleyman T, et al. Interactions between intersubunit transmembrane domains regulate the chaperone-dependent degradation of an oligomeric membrane protein. Biochem J. 2017;474:357-376 pubmed publisher
    ..We previously established that a conserved, ER lumenal, molecular chaperone, Lhs1/GRP170, selects ?ENaC, but not ?- or ?-ENaC, for degradation when the ENaC subunits were individually expressed...
  52. Williams J, Inoue T, Chen G, Tsai B. The nucleotide exchange factors Grp170 and Sil1 induce cholera toxin release from BiP to enable retrotranslocation. Mol Biol Cell. 2015;26:2181-9 pubmed publisher
    ..approaches coupled with binding studies, we demonstrate that the ER-resident nucleotide exchange factors (NEFs) Grp170 and Sil1 induce CT release from BiP in order to promote toxin retrotranslocation...
  53. Tyler R, Pearce M, Shaler T, Olzmann J, Greenblatt E, Kopito R. Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate. Mol Biol Cell. 2012;23:4668-78 pubmed publisher
    ..These data establish unassembled CD147(CG) as an endogenous, constitutive ERAD substrate of the OS-9/SEL1L/Hrd1 pathway. ..
  54. Kitao Y, Matsuyama T, Takano K, Tabata Y, Yoshimoto T, Momoi T, et al. Does ORP150/HSP12A protect dopaminergic neurons against MPTP/MPP(+)-induced neurotoxicity?. Antioxid Redox Signal. 2007;9:589-95 pubmed
    ..What is the significance of ORP150/HSP12A, a molecular chaperone in the endoplasmic reticulum (ER), in the nigrostriatal system? Dopaminergic ..
  55. Sanson M, Ingueneau C, Vindis C, Thiers J, Glock Y, Rousseau H, et al. Oxygen-regulated protein-150 prevents calcium homeostasis deregulation and apoptosis induced by oxidized LDL in vascular cells. Cell Death Differ. 2008;15:1255-65 pubmed publisher
    ..The 150 kDa oxygen-regulated protein (ORP150), an endoplasmic reticulum (ER)-resident chaperone, is upregulated by hypoxia and prevents ischemia-induced cell ..
  56. Inoue T, Tsai B. A nucleotide exchange factor promotes endoplasmic reticulum-to-cytosol membrane penetration of the nonenveloped virus simian virus 40. J Virol. 2015;89:4069-79 pubmed publisher
    ..We found that nucleotide exchange factor (NEF) Grp170 induces nucleotide exchange of BiP and releases SV40 from BiP...
  57. Ni M, Lee A. ER chaperones in mammalian development and human diseases. FEBS Lett. 2007;581:3641-51 pubmed
    ..Here, we summarized the properties and functions of GRP78/BiP, GRP94/gp96, GRP170/ORP150, GRP58/ERp57, PDI, ERp72, calnexin, calreticulin, EDEM, Herp and co-chaperones SIL1 and P58(IPK) and their ..
  58. Miyagi T, Hori O, Egawa M, Kato H, Kitagawa Y, Konaka H, et al. Antitumor effect of reduction of 150-kDa oxygen-regulated protein expression in human prostate cancer cells. Mol Urol. 2001;5:79-80 pubmed
    ..The 150-kDa oxygen-regulated protein (ORP150), a new member of HSP family, functions as a molecular chaperone in the endoplasmic reticulum...
  59. Cechowska Pasko M, Surazynski A, Bankowski E. The effect of glucose deprivation on collagen synthesis in fibroblast cultures. Mol Cell Biochem. 2009;327:211-8 pubmed publisher
    ..fibroblast cultures and a correlation of these processes with the expression of oxygen/glucose regulated proteins (ORP150/GRP170)...
  60. Wang Y, Wu Z, Li D, Wang D, Wang X, Feng X, et al. Involvement of oxygen-regulated protein 150 in AMP-activated protein kinase-mediated alleviation of lipid-induced endoplasmic reticulum stress. J Biol Chem. 2011;286:11119-31 pubmed publisher
    ..active AMPK overexpression induced the expression of an ER-associated chaperone, 150-kDa oxygen-regulated protein (ORP150), at both the mRNA and protein levels in hepatocytes...
  61. Tsukamoto Y, Kuwabara K, Hirota S, Kawano K, Yoshikawa K, Ozawa K, et al. Expression of the 150-kd oxygen-regulated protein in human breast cancer. Lab Invest. 1998;78:699-706 pubmed
    ..The 150-kd oxygen-regulated protein (ORP150) is a novel endoplasmic reticulum-associated polypeptide in the HSP70 family...