Gene Symbol: OXT
Description: oxytocin/neurophysin I prepropeptide
Alias: OT-NPI, OXT-NPI, oxytocin-neurophysin 1, neurophysin I, oxytocin, prepro- (neurophysin I), oxytocin, prepropeptide, oxytocin-neurophysin I, preproprotein
Species: human
Products:     OXT

Top Publications

  1. Ebstein R, Knafo A, Mankuta D, Chew S, Lai P. The contributions of oxytocin and vasopressin pathway genes to human behavior. Horm Behav. 2012;61:359-79 pubmed publisher
    ..vasopressin 1a receptor (AVPR1a), oxytocin receptor (OXTR), AVP (AVP-neurophysin II [NPII]) and OXT (OXT neurophysin I [NPI]), oxytocinase/vasopressinase (LNPEP), ADP-ribosyl cyclase (CD38) and arginine vasopressin 1b receptor (..
  2. Rao V, Loffler C, Battey J, Hansmann I. The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization. Cytogenet Cell Genet. 1992;61:271-3 pubmed
    ..these hormones are synthesized as inactive precursors in the hypothalamus along with their carrier proteins neurophysin I and neurophysin II respectively and are activated upon transport to posterior pituitary...
  3. Feldman R, Zagoory Sharon O, Weisman O, Schneiderman I, Gordon I, Maoz R, et al. Sensitive parenting is associated with plasma oxytocin and polymorphisms in the OXTR and CD38 genes. Biol Psychiatry. 2012;72:175-81 pubmed publisher
    ..These findings may have important implications for understanding neuropsychiatric disorders marked by early social dysfunctions. ..
  4. De Dreu C. Oxytocin modulates cooperation within and competition between groups: an integrative review and research agenda. Horm Behav. 2012;61:419-28 pubmed publisher
    ..quot; This review concludes with avenues for new research on oxytocin's functions in within-group cooperation and between-group competition. This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior. ..
  5. Pierce M, Mehrotra S, Mustoe A, French J, Murray T. A Comparison of the Ability of Leu8- and Pro8-Oxytocin to Regulate Intracellular Ca2+ and Ca2+-Activated K+ Channels at Human and Marmoset Oxytocin Receptors. Mol Pharmacol. 2019;95:376-385 pubmed publisher
    ..In marmosets (Callithrix), a nonsynonymous nucleotide substitution in the OXT gene codes for proline in the eighth residue position (Pro8-OT)...
  6. Patrick R, Ames B. Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism. FASEB J. 2014;28:2398-413 pubmed publisher
    ..peptide hormones, oxytocin and vasopressin, are also associated with autism and genes encoding the oxytocin-neurophysin I preproprotein, the oxytocin receptor, and the arginine vasopressin receptor contain VDREs for activation...
  7. Maud C, Ryan J, McIntosh J, Olsson C. The role of oxytocin receptor gene (OXTR) DNA methylation (DNAm) in human social and emotional functioning: a systematic narrative review. BMC Psychiatry. 2018;18:154 pubmed publisher
    The neuropeptide Oxytocin (OXT) plays a central role in birthing, mother-infant bonding and a broad range of related social behaviours in mammals...
  8. Hidema S, Fukuda T, Hiraoka Y, Mizukami H, Hayashi R, Otsuka A, et al. Generation of Oxtr cDNA(HA)-Ires-Cre Mice for Gene Expression in an Oxytocin Receptor Specific Manner. J Cell Biochem. 2016;117:1099-111 pubmed publisher
    The neurohypophysial hormone oxytocin (OXT) and its receptor (OXTR) have critical roles in the regulation of pro-social behaviors, including social recognition, pair bonding, parental behavior, and stress-related responses...
  9. Bytautiene Prewit E, Kechichian T, Okunade D, Yin H, Stuebe A. Effect of Normal Pregnancy Followed by Lactation on Long-Term Maternal Health in a Mouse Model. Reprod Sci. 2017;:1933719117734316 pubmed publisher
    ..Circulating oxytocin (OXT) levels were significantly higher in PG mice...

More Information

Publications131 found, 100 shown here

  1. Schmidt M, Braun K, Brandwein C, Rossetti A, Guara Ciurana S, Riva M, et al. Maternal stress during pregnancy induces depressive-like behavior only in female offspring and correlates to their hippocampal Avp and Oxt receptor expression. Behav Brain Res. 2018;353:1-10 pubmed publisher
  2. Lagergren K, Ek W, Levine D, Chow W, Bernstein L, Casson A, et al. Polymorphisms in Genes of Relevance for Oestrogen and Oxytocin Pathways and Risk of Barrett's Oesophagus and Oesophageal Adenocarcinoma: A Pooled Analysis from the BEACON Consortium. PLoS ONE. 2015;10:e0138738 pubmed publisher
    ..and aromatase (CYP19A1)), and 3 key genes of the oxytocin pathway (the oxytocin receptor (OXTR), oxytocin protein (OXT), and cyclic ADP ribose hydrolase glycoprotein (CD38)), were analysed using a gene-based approach, versatile gene-..
  3. Ergang P, Vodička M, Soták M, Klusoňová P, Behuliak M, Řeháková L, et al. Differential impact of stress on hypothalamic-pituitary-adrenal axis: gene expression changes in Lewis and Fisher rats. Psychoneuroendocrinology. 2015;53:49-59 pubmed publisher
    ..corticotropin-releasing hormone (CRH), urocortins 2 and 3(UCN2, UCN3), arginine vasopressin (AVP), oxytocin (OXT) and adenylate cyclase-activating polypeptide (PACAP) in two inbred rat strains: stress hypo-responsive Lewis (LEW) ..
  4. Enami N, Itaya Hironaka A, Yamauchi A, Sakuramoto Tsuchida S, Takasawa S, Takahashi Y. The CD38 genotype (rs1800561 (4693C>T): R140W) is associated with an increased risk of admission to the neonatal intensive care unit. Early Hum Dev. 2015;91:467-70 pubmed publisher
    ..Given the role of CD38 in term delivery through oxytocin (OXT) release, we hypothesized that OXT signaling may play a role in the etiology of PTB/admission to the NICU...
  5. Jung C, Wernly B, Bjursell M, Wiseman J, Admyre T, Wikström J, et al. Cardiac-Specific Overexpression of Oxytocin Receptor Leads to Cardiomyopathy in Mice. J Card Fail. 2018;24:470-478 pubmed publisher
    Oxytocin (Oxt) and its receptor (Oxtr) gene system has been implicated in cardiomyogenesis and cardioprotection; however, effects of chronic activation of Oxtr are not known...
  6. Pobbe R, Pearson B, Defensor E, Bolivar V, Young W, Lee H, et al. Oxytocin receptor knockout mice display deficits in the expression of autism-related behaviors. Horm Behav. 2012;61:436-44 pubmed publisher
    A wealth of studies has implicated oxytocin (Oxt) and its receptors (Oxtr) in the mediation of social behaviors and social memory in rodents...
  7. Hovey D, Lindstedt M, Zettergren A, Jonsson L, Johansson A, Melke J, et al. Antisocial behavior and polymorphisms in the oxytocin receptor gene: findings in two independent samples. Mol Psychiatry. 2016;21:983-8 pubmed publisher
    ..Emerging evidence suggests that the neuropeptide oxytocin (OXT) may modulate interpersonal aggression...
  8. Feldman R, Monakhov M, Pratt M, Ebstein R. Oxytocin Pathway Genes: Evolutionary Ancient System Impacting on Human Affiliation, Sociality, and Psychopathology. Biol Psychiatry. 2016;79:174-84 pubmed publisher
    ..research on the three genes most extensively studied in humans: the OT receptor (OXTR), the structural gene for OT (OXT/neurophysin-I), and CD38...
  9. Li K, Nakajima M, Ibanez Tallon I, Heintz N. A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors. Cell. 2016;167:60-72.e11 pubmed publisher
    ..reveal a molecular mechanism that acts on local medial prefrontal cortex (mPFC) circuits to coordinate responses to OXT and CRH...
  10. Lin Y, Chen C, Huang C, Nishimori K, Hsu K. Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons. Nat Commun. 2017;8:537 pubmed publisher
    ..Our findings reveal a critical role for oxytocin signaling in adult neurogenesis.Oxytocin (OXT) has been implicated in adult neurogenesis...
  11. King L, Robins S, Chen G, Yerko V, Zhou Y, Nagy C, et al. Perinatal depression and DNA methylation of oxytocin-related genes: a study of mothers and their children. Horm Behav. 2017;96:84-94 pubmed publisher
    ..child dyads: exon 3 within the oxytocin receptor (OXTR) gene and 2 intergenic regions (IGR) between the oxytocin (OXT) and vasopressin (AVP) genes. Maternal PD was assessed at 5 time-points during pregnancy and postpartum...
  12. Smith C, Dibenedictis B, Veenema A. Comparing vasopressin and oxytocin fiber and receptor density patterns in the social behavior neural network: Implications for cross-system signaling. Front Neuroendocrinol. 2019;: pubmed publisher
    Vasopressin (AVP) and oxytocin (OXT) regulate social behavior by binding to their canonical receptors, the vasopressin V1a receptor (V1aR) and oxytocin receptor (OTR), respectively...
  13. Wojciechowska A, Mlynarczuk J, Kotwica J. Changes in the mRNA expression of structural proteins, hormone synthesis and secretion from bovine placentome sections after DDT and DDE treatment. Toxicology. 2017;375:1-9 pubmed publisher
    ..Both DDT and DDE increased (P<0.05) neurophysin I/oxytocin (NP1/OT) mRNA expression and oxytocin (OT), oestradiol (E2) and progesterone (P4) secretion while DDT ..
  14. Møller M, Busch J, Jacobsen C, Lundemose S, Lynnerup N, Rath M, et al. The accessory magnocellular neurosecretory system of the rostral human hypothalamus. Cell Tissue Res. 2018;373:487-498 pubmed publisher
    ..Paraffin sections were either stained with Luxol Fast blue or immunoreacted for neurophysin I or neurophysin II, the precursor molecule for oxytocin and vasopressin...
  15. Kleszczewski T, Modzelewska B, Bal W, Sipowicz M, Kleszczewska E, Kostrzewska A. Cu(II) complexation does not affect oxytocin action on pregnant human myometrium in vitro. Reprod Toxicol. 2016;59:60-5 pubmed publisher
    ..Recent evidence shows that cupric ions can easily form complexes with oligopeptides like oxytocin (OXT). The high complex stability in vitro suggests a possibility of complex formation in vivo...
  16. Miyazaki S, Hiraoka Y, Hidema S, Nishimori K. Prenatal minocycline treatment alters synaptic protein expression, and rescues reduced mother call rate in oxytocin receptor-knockout mice. Biochem Biophys Res Commun. 2016;472:319-23 pubmed publisher
    ..Our results suggest that microglial abnormality is a potential mechanism of the development of Oxt/Oxtr mediated ASD-like phenotypes.
  17. Stohn J, Martinez M, Zafer M, López Espíndola D, Keyes L, Hernandez A. Increased aggression and lack of maternal behavior in Dio3-deficient mice are associated with abnormalities in oxytocin and vasopressin systems. Genes Brain Behav. 2017;: pubmed publisher
    ..social behaviors of Dio3-/- mice were associated with sexually dimorphic alterations in the physiology of oxytocin (OXT) and arginine vasopressin (AVP), 2 neuropeptides with important roles in determining social interactions...
  18. Garcia A, Depena C, Bezner K, Yin W, Gore A. The timing and duration of estradiol treatment in a rat model of the perimenopause: Influences on social behavior and the neuromolecular phenotype. Horm Behav. 2018;97:75-84 pubmed publisher
    ..with the majority of changes found for genes involved in regulating social behavior such as neuropeptides (Oxt, Oxtr &Avp), neurotransmitters (Drd1, Drd2, Htr2a, Grin2d &Gabbr1), and steroid hormone receptors (Esr2, Ar,..
  19. Ryan P, Ross S, Campos C, Derkach V, Palmiter R. Oxytocin-receptor-expressing neurons in the parabrachial nucleus regulate fluid intake. Nat Neurosci. 2017;20:1722-1733 pubmed publisher
    ..OxtrPBN neurons were directly innervated by oxytocin neurons in the paraventricular hypothalamus (OxtPVH neurons), which mildly attenuated fluid intake...
  20. Micali N, Crous Bou M, Treasure J, Lawson E. Association Between Oxytocin Receptor Genotype, Maternal Care, and Eating Disorder Behaviours in a Community Sample of Women. Eur Eat Disord Rev. 2017;25:19-25 pubmed publisher
    This study aimed to investigate associations between oxytocin receptor gene (OXT-R) polymorphisms (rs53576 and rs2254298), their interaction with maternal care (GxE), and ED behaviours in a community sample...
  21. Herget U, Ryu S. Coexpression analysis of nine neuropeptides in the neurosecretory preoptic area of larval zebrafish. Front Neuroanat. 2015;9:2 pubmed publisher
    ..AVP), corticotropin-releasing hormone (CRH), proenkephalin a (penka)/b (penkb), neurotensin (NTS), oxytocin (OXT), vasoactive intestinal peptide (VIP), cholecystokinin (CCK), and somatostatin (SST))...
  22. Lin Y, Hsu K. Oxytocin receptor signaling in the hippocampus: Role in regulating neuronal excitability, network oscillatory activity, synaptic plasticity and social memory. Prog Neurobiol. 2018;171:1-14 pubmed publisher
    Beyond its well-known role in reproduction, the hypothalamic neuropeptide oxytocin (OXT) has been implicated in a broad spectrum of social and nonsocial behaviors...
  23. Mayasich S, Bemis L, Clarke B. DNA methylation in a sea lamprey vasotocin receptor gene promoter correlates with tissue- and life-stage-specific mRNA expression. Comp Biochem Physiol B Biochem Mol Biol. 2016;202:56-66 pubmed publisher
    ..AVT) receptor gene (Pm807) possessing characteristics of both arginine vasopressin (AVP) V1A and oxytocin (OXT) receptor genes of jawed vertebrates...
  24. Ci H, Wu N, Su Y. Clock gene modulates roles of OXTR and AVPR1b genes in prosociality. PLoS ONE. 2014;9:e109086 pubmed publisher
    ..The observed interaction effects provide converging evidence that the clock gene and OXT/AVP systems are intertwined and contribute to human prosociality.
  25. Yan Y, Tian L, Xiang X, Ding W, Song G, Xu J. Chronic gastric electrical stimulation leads to weight loss via modulating multiple tissue neuropeptide Y, orexin, α-melanocyte-stimulating hormone and oxytocin in obese rats. Scand J Gastroenterol. 2016;51:157-67 pubmed publisher
    ..the regulation of neuropeptide Y (NPY), orexin (OX), α-melanocyte-stimulating hormone (α-MSH) and oxytocin (OXT), and their receptors in several tissues...
  26. Kraaijenvanger E, He Y, Spencer H, Smith A, Bos P, Boks M. Epigenetic variability in the human oxytocin receptor (OXTR) gene: A possible pathway from early life experiences to psychopathologies. Neurosci Biobehav Rev. 2019;96:127-142 pubmed publisher
    The human oxytocin (OXT) system is implicated in the regulation of complex social behaviors, as well as in psychopathologies characterized by social deficits...
  27. Fu Y, Selcuk E, Moore S, Depue R. Touch-induced face conditioning is mediated by genetic variation in opioid but not oxytocin receptors. Sci Rep. 2018;8:9004 pubmed publisher
    ..Touch activates opioids (OP) and oxytocin (OXT), two neuromodulators involved in affiliative behaviors and social bonding...
  28. Osada K, Ohta T, Takai R, Miyazono S, Kashiwayanagi M, Hidema S, et al. Oxytocin receptor signaling contributes to olfactory avoidance behavior induced by an unpleasant odorant. Biol Open. 2018;: pubmed publisher
    Oxytocin (OXT) and its receptor (OXTR) regulate reproductive physiology (i.e., parturition and lactation), sociosexual behavior, learned patterns of behavior, and olfactory behavior in social contexts...
  29. Waller R, Corral Frias N, Vannucci B, Bogdan R, Knodt A, Hariri A, et al. An oxytocin receptor polymorphism predicts amygdala reactivity and antisocial behavior in men. Soc Cogn Affect Neurosci. 2016;11:1218-26 pubmed publisher
    Variability in oxytocin (OXT) signaling is associated with individual differences in sex-specific social behavior across species...
  30. van den Brink W, Wong Y, Gülave B, van der Graaf P, de Lange E. Revealing the Neuroendocrine Response After Remoxipride Treatment Using Multi-Biomarker Discovery and Quantifying It by PK/PD Modeling. AAPS J. 2017;19:274-285 pubmed publisher
    ..LH), and thyroid stimulating hormones (TSH) did not respond to remoxipride at the tested doses, while oxytocin (OXT) measurements were below limit of quantification...
  31. Wircer E, Blechman J, Borodovsky N, Tsoory M, Nunes A, Oliveira R, et al. Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior. elife. 2017;6: pubmed publisher
    ..These behavioral phenotypes were associated with developmental alterations in oxytocinergic (OXT) neurons...
  32. Davis C, Patte K, Zai C, Kennedy J. Polymorphisms of the oxytocin receptor gene and overeating: the intermediary role of endophenotypic risk factors. Nutr Diabetes. 2017;7:e279 pubmed publisher
    Oxytocin (OXT) is an evolutionarily ancient neuropeptide with strong links to affiliative and prosocial behaviors, and the management of stress. Increases in OXT also tend to decrease food intake, especially of sweet carbohydrates...
  33. Evans J, Reid R, Wakeman S, Croft L, Benny P. Evidence that oxytocin is a physiological component of LH regulation in non-pregnant women. Hum Reprod. 2003;18:1428-31 pubmed
    ..The results indicated that inhibition of endogenous oxytocin affects the endocrinology of the ovulatory cycle in women, and strongly suggest that oxytocin has a role in the physiological processes of LH regulation. ..
  34. Souza R, De Luca V, Meltzer H, Lieberman J, Kennedy J. Schizophrenia severity and clozapine treatment outcome association with oxytocinergic genes. Int J Neuropsychopharmacol. 2010;13:793-8 pubmed publisher
    ..Previous findings connect oxytocin (OXT) with schizophrenia and antipsychotic action...
  35. Kim T, Kim J, Choi J, Park J, Lee J, Lee E, et al. Local Interleukin-18 System in the Basolateral Amygdala Regulates Susceptibility to Chronic Stress. Mol Neurobiol. 2017;54:5347-5358 pubmed publisher
    ..The siRNA-mediated inhibition of NF-kB in the BLA downregulated stress-induced increased expression of Hcrt, MCH, OXT, AVP, and TRH, the neuropeptides that were induced by chronic stress in the BLA and promoted depression-like ..
  36. Fields R, Ponzio T, Kawasaki M, Gainer H. Cell-type specific oxytocin gene expression from AAV delivered promoter deletion constructs into the rat supraoptic nucleus in vivo. PLoS ONE. 2012;7:e32085 pubmed publisher
    The magnocellular neurons (MCNs) in the hypothalamus selectively express either oxytocin (OXT) or vasopressin (AVP) neuropeptide genes, a property that defines their phenotypes...
  37. Amad A, Thomas P, Perez Rodriguez M. Borderline Personality Disorder and Oxytocin: Review of Clinical Trials and Future Directions. Curr Pharm Des. 2015;21:3311-6 pubmed
    ..This review focuses on the potential use of intranasal oxytocin (OXT), which has key roles in the regulation of complex social cognition and behaviors, to target symptoms of ..
  38. Motojima Y, Kawasaki M, Matsuura T, Saito R, Yoshimura M, Hashimoto H, et al. Effects of peripherally administered cholecystokinin-8 and secretin on feeding/drinking and oxytocin-mRFP1 fluorescence in transgenic rats. Neurosci Res. 2016;109:63-9 pubmed publisher
    Peripheral administration of cholecystokinin (CCK)-8 or secretin activates oxytocin (OXT)-secreting neurons in the hypothalamus. Although OXT is involved in the regulation of feeding behavior, detailed mechanism remains unclear...
  39. Naja W, Aoun M. Oxytocin and Anxiety Disorders: Translational and Therapeutic Aspects. Curr Psychiatry Rep. 2017;19:67 pubmed publisher
    This review aims to evaluate the most recent literature examining the oxytocin (OXT) system's role in human anxiety by surveying various fields of preclinical and clinical research supporting this role, and queries whether the OXT system ..
  40. Fujiwara T, Kubzansky L, Matsumoto K, Kawachi I. The association between oxytocin and social capital. PLoS ONE. 2012;7:e52018 pubmed publisher
    ..No association between oxytocin and social capital was found among men. Further study is needed to elucidate why oxytocin was inversely associated with cognitive social capital only among women. ..
  41. Kim S, MacIntyre D, Firmino Da Silva M, Blanks A, Lee Y, Thornton S, et al. Oxytocin activates NF-κB-mediated inflammatory pathways in human gestational tissues. Mol Cell Endocrinol. 2015;403:64-77 pubmed publisher
  42. Gutkowska J, Jankowski M, Mukaddam Daher S, McCann S. Oxytocin is a cardiovascular hormone. Braz J Med Biol Res. 2000;33:625-33 pubmed
    ..Therefore, locally produced OT may have important regulatory functions within the heart and vascular beds. Such functions may include slowing down of the heart or the regulation of local vascular tone. ..
  43. Petersson M. Opposite effects of oxytocin on proliferation of osteosarcoma cell lines. Regul Pept. 2008;150:50-4 pubmed publisher
    ..001). Thus oxytocin has the capacity to both stimulate and inhibit cell proliferation of osteosarcoma cells. This effect might be dependent on the stage of differentiation of the cancer cells. ..
  44. Hong S, Kyeong K, Kim C, Kim Y, Choi W, Yoo R, et al. Regulation of myometrial contraction by ATP-sensitive potassium (KATP) channel via activation of SUR2B and Kir 6.2 in mouse. J Vet Med Sci. 2016;78:1153-9 pubmed publisher
    ..KCOs inhibited oxytocin (OXT)- and prostaglandin F2? (PGF2?)-induced phasic contractions in a glibenclamide-sensitive manner. SUR2B and Kir6...
  45. Rebordão M, Galvão A, Pinto Bravo P, Pinheiro J, Gamboa S, Silva E, et al. Endometrial prostaglandin synthases, ovarian steroids, and oxytocin receptors in mares with oxytocin-induced luteal maintenance. Theriogenology. 2017;87:193-204 pubmed publisher
    Oxytocin (OXT) has been used to prolong the luteal phase in mares, but its mechanism of action is unknown...
  46. York N, Halbach P, Chiu M, Bird I, Pillers D, Pattnaik B. Oxytocin (OXT)-stimulated inhibition of Kir7.1 activity is through PIP2-dependent Ca2+ response of the oxytocin receptor in the retinal pigment epithelium in vitro. Cell Signal. 2017;37:93-102 pubmed publisher
    Oxytocin (OXT) is a neuropeptide that activates the oxytocin receptor (OXTR), a rhodopsin family G-protein coupled receptor...
  47. Pequeux C, Breton C, Hendrick J, Hagelstein M, Martens H, Winkler R, et al. Oxytocin synthesis and oxytocin receptor expression by cell lines of human small cell carcinoma of the lung stimulate tumor growth through autocrine/paracrine signaling. Cancer Res. 2002;62:4623-9 pubmed
    ..Furthermore, these findings point to the potential of OT antagonists for development as therapeutic agents for the treatment of SCCL. ..
  48. Coiro V, Saccani Jotti G, Rubino P, Manfredi G, Vacca P, Volta E, et al. Oxytocin inhibits the stimulatory effect of ghrelin on circulating neuropeptide Y levels in humans. J Neural Transm (Vienna). 2008;115:1265-7 pubmed publisher
    ..When OT was present, ghrelin-induced NPY increment was completely abolished. Results show that oxytocin modulates the NPY response to ghrelin, whereas it is unable to produce direct inhibitions of basal circulating NPY levels. ..
  49. Xu X, Shou X, Li J, Jia M, Zhang J, Guo Y, et al. Mothers of autistic children: lower plasma levels of oxytocin and Arg-vasopressin and a higher level of testosterone. PLoS ONE. 2013;8:e74849 pubmed publisher
    ..We hypothesized that dysregulation of oxytocin (OXT), Arg-vasopressin (AVP) and sex hormones, found in autistic children, may also exist in their mothers...
  50. Martin J, Kagerbauer S, Schuster T, Blobner M, Kochs E, Landgraf R. Vasopressin and oxytocin in CSF and plasma of patients with aneurysmal subarachnoid haemorrhage. Neuropeptides. 2014;48:91-6 pubmed publisher
    ..The implication of the hypothalamic neuropeptides arginine-vasopressin (AVP) and oxytocin (OXT) has not been linked to aneurysmal SAH yet...
  51. Petersson M, Lagumdzija A, Stark A, Bucht E. Oxytocin stimulates proliferation of human osteoblast-like cells. Peptides. 2002;23:1121-6 pubmed
    ..Oxytocin 100 pmol/l decreased interleukin-6 (IL-6) production of the hOB cells (23.4+/-1.96 versus 33.4+/-2.65 pg/well; P<0.001). These findings indicate that oxytocin may affect bone metabolism in humans. ..
  52. Malvasi A, Cavallotti C, Nicolardi G, Pellegrino M, Vergara D, Greco M, et al. The opioid neuropeptides in uterine fibroid pseudocapsules: a putative association with cervical integrity in human reproduction. Gynecol Endocrinol. 2013;29:982-8 pubmed publisher
    ..We investigated the distribution of the opioid neuropeptides, as enkephalin (ENK) and oxytocin (OXT), in the nerve fibers within MP and their possible influence in human reproduction in 57 women...
  53. Spikol E, Glasgow E. Separate roles for Med12 and Wnt signaling in regulation of oxytocin expression. Biol Open. 2018;7: pubmed publisher
    ..within the hypothalamo-pituitary axis of med12 mutant zebrafish embryos with a focus on oxytocin (oxt) expression...
  54. Assinder S. Oxytocin increases 5alpha-reductase activity of human prostate epithelial cells, but not stromal cells. Prostate. 2008;68:115-21 pubmed
    ..Both 5-alpha-reductase I and II are expressed in normal human prostate stromal and epithelial cells. Only 5-alpha-reductase isoenzymes of prostate epithelium are modulated by oxytocin. ..
  55. Jong T, Menon R, Bludau A, Grund T, Biermeier V, Klampfl S, et al. Salivary oxytocin concentrations in response to running, sexual self-stimulation, breastfeeding and the TSST: The Regensburg Oxytocin Challenge (ROC) study. Psychoneuroendocrinology. 2015;62:381-8 pubmed publisher
    Intranasal oxytocin (OXT) application is emerging as a potential treatment for socio-emotional disorders associated with abnormalities in OXT system (re-) activity...
  56. Wade M, Hoffmann T, Knafo Noam A, O CONNOR T, Jenkins J. Oxytocin and vasopressin hormone genes in children's externalizing problems: A cognitive endophenotype approach. Horm Behav. 2016;82:78-86 pubmed publisher
    ..Markers of the oxytocin (OXT) and arginine vasopressin (AVP) hormone genes were selected as candidates owing to their known association with ..
  57. Zhang H, Dai Y, Wu J, Jia M, Zhang J, Shou X, et al. Plasma Oxytocin and Arginine-Vasopressin Levels in Children with Autism Spectrum Disorder in China: Associations with Symptoms. Neurosci Bull. 2016;32:423-32 pubmed publisher
    ..The "twin" nonapeptides oxytocin (OXT) and arginine-vasopressin (AVP) are known to play regulatory roles in social behaviors...
  58. Viaux Savelon S, Rosenblum O, Guedeney A, Diene G, Çabal Berthoumieu S, Fichaux Bourin P, et al. Dyssynchrony and perinatal psychopathology impact of child disease on parents-child interactions, the paradigm of Prader Willi syndrom. J Physiol Paris. 2016;110:427-433 pubmed publisher
    ..As a consequence, parent-infant interaction is impaired. In a recent study (Tauber et al., 2017), OXT intranasal infusion was able to partially reverse the feeding phenotype, infant's behavior and brain connectivity...
  59. Cassoni P, Sapino A, Marrocco T, Chini B, Bussolati G. Oxytocin and oxytocin receptors in cancer cells and proliferation. J Neuroendocrinol. 2004;16:362-4 pubmed
  60. Garrott K, Dyavanapalli J, Cauley E, Dwyer M, Kuzmiak Glancy S, Wang X, et al. Chronic activation of hypothalamic oxytocin neurons improves cardiac function during left ventricular hypertrophy-induced heart failure. Cardiovasc Res. 2017;113:1318-1328 pubmed publisher
    ..Recent work suggests that activation of hypothalamic oxytocin (OXT) neurons could improve autonomic balance during HF...
  61. Godínez Chaparro B, Martínez Lorenzana G, Rodríguez Jiménez J, Manzano García A, Rojas Piloni G, Condés Lara M, et al. The potential role of serotonergic mechanisms in the spinal oxytocin-induced antinociception. Neuropeptides. 2016;60:51-60 pubmed publisher
    The role of oxytocin (OXT) in pain modulation has been suggested. Indeed, hypothalamic paraventricular nuclei (PVN) electrical stimuli reduce the nociceptive neuronal activity (i.e...
  62. Akour A, Kasabri V, Boulatova N, Bustanji Y, Naffa R, Hyasat D, et al. Levels of metabolic markers in drug-naive prediabetic and type 2 diabetic patients. Acta Diabetol. 2017;54:163-170 pubmed publisher
    ..of omentin, irisin, endothelin-1, nesfatin, hepatocyte growth factor (HGF), fibroblast growth factor, and oxytocin (OXT) between normoglycemic and pre-DM/T2DM obese Jordanian patients...
  63. Santoso P, Nakata M, Ueta Y, Yada T. Suprachiasmatic Vasopressin to Paraventricular Oxytocin Neurocircuit in the Hypothalamus Relays Light Reception to Inhibition of Feeding Behavior. Am J Physiol Endocrinol Metab. 2017;:ajpendo.00338.2016 pubmed publisher
    ..food intake and elevated c-Fos expression in the arginine vasopressin (AVP) neurons of SCN and the oxytocin (Oxt) neurons of paraventricular nucleus (PVN) in the hypothalamus...
  64. Chong A, Chew S, Lai P, Ebstein R, Gouin J. The role of the Oxytocin-Neurophysin I gene in contributing to human personality traits promoting sociality. Int J Psychophysiol. 2019;136:81-86 pubmed publisher
    ..Curiously, the OXT-Neurophysin I gene has been little studied despite the fact this is the structural gene for the OT nonapeptide...
  65. Kim T, Lee J, Kim J, Park J, Choi J, Kim H, et al. G9a-Mediated Regulation of OXT and AVP Expression in the Basolateral Amygdala Mediates Stress-Induced Lasting Behavioral Depression and Its Reversal by Exercise. Mol Neurobiol. 2016;53:2843-2856 pubmed publisher
    ..Of these genes, the neuropeptides oxytocin (OXT) and arginine vasopressin (AVP) were selected as representative stress-induced and exercise-responded genes in the ..
  66. Oztan O, Jackson L, Libove R, Sumiyoshi R, Phillips J, Garner J, et al. Biomarker discovery for disease status and symptom severity in children with autism. Psychoneuroendocrinology. 2018;89:39-45 pubmed publisher
    ..Recent preclinical ASD biomarker discovery research has implicated the neuropeptides oxytocin (OXT) and arginine vasopressin (AVP), and their receptors, OXTR and AVPR1A, in animal models...
  67. Yrigollen C, Han S, Kochetkova A, Babitz T, Chang J, Volkmar F, et al. Genes controlling affiliative behavior as candidate genes for autism. Biol Psychiatry. 2008;63:911-6 pubmed publisher
    ..associations between genetic variants in six genes involved in control of maternal and affiliative behaviors (OXT, OXTR, PRL, PRLR, DbetaH, and FOSB)...
  68. Pinto Bravo P, Galvao A, Rebordão M, Amaral A, Ramilo D, Silva E, et al. Ovarian steroids, oxytocin, and tumor necrosis factor modulate equine oviduct function. Domest Anim Endocrinol. 2017;61:84-99 pubmed publisher
    ..Estradiol (E2), progesterone (P4), oxytocin (OXT), and tumor necrosis factor ? (TNF) effect on in vitro PGE2 and prostaglandin F2? (PGF2?) ..
  69. Grund T, Goyon S, Li Y, Eliava M, Liu H, Charlet A, et al. Neuropeptide S Activates Paraventricular Oxytocin Neurons to Induce Anxiolysis. J Neurosci. 2017;37:12214-12225 pubmed publisher
    Neuropeptides, such as neuropeptide S (NPS) and oxytocin (OXT), represent potential options for the treatment of anxiety disorders due to their potent anxiolytic profile...
  70. Meynen G, Unmehopa U, Hofman M, Swaab D, Hoogendijk W. Hypothalamic oxytocin mRNA expression and melancholic depression. Mol Psychiatry. 2007;12:118-9 pubmed
  71. Colaianni G, Di Benedetto A, Zhu L, Tamma R, Li J, Greco G, et al. Regulated production of the pituitary hormone oxytocin from murine and human osteoblasts. Biochem Biophys Res Commun. 2011;411:512-5 pubmed publisher
    ..We surmise that there is a local feed-forward loop in bone marrow through which the OT so produced from osteoblasts in response to estrogen acts upon its receptor to exert a potent anabolic action. ..
  72. Sasaki T, Hashimoto K, Oda Y, Ishima T, Kurata T, Takahashi J, et al. Decreased levels of serum oxytocin in pediatric patients with Attention Deficit/Hyperactivity Disorder. Psychiatry Res. 2015;228:746-51 pubmed publisher
    ..Accumulating evidence suggests that ASD patients have significantly lower peripheral oxytocin (OXT) levels compared with their normal counterparts, and that the repetitive behavior seen in ASD is related to ..
  73. Koida M, Walter R. Post-proline cleaving enzyme. Purification of this endopeptidase by affinity chromatography. J Biol Chem. 1976;251:7593-9 pubmed
    ..Human gastrin, adrenocorticotropic hormone, denatured guinea pig skin collagen, and ascaris cuticle collagen were not degraded. Dipeptides with the structure Z-Pro-LD-X competitively inhibit post-proline cleaving enzyme. ..
  74. Beitchman J, Zai C, Muir K, Berall L, Nowrouzi B, Choi E, et al. Childhood aggression, callous-unemotional traits and oxytocin genes. Eur Child Adolesc Psychiatry. 2012;21:125-32 pubmed publisher
    ..Given the small sample size and the possibility of false positive effects, the need to replicate and verify these findings is required. ..
  75. Smith T, Uchino B, MacKenzie J, Hicks A, Campo R, Reblin M, et al. Effects of couple interactions and relationship quality on plasma oxytocin and cardiovascular reactivity: empirical findings and methodological considerations. Int J Psychophysiol. 2013;88:271-81 pubmed publisher
    ..However, findings were consistent with the view that CVR contributes to the effects of relationship difficulties on health. ..
  76. Opacka Juffry J, Mohiyeddini C. Experience of stress in childhood negatively correlates with plasma oxytocin concentration in adult men. Stress. 2012;15:1-10 pubmed publisher
    ..These results contribute to the evidence that early life adverse experience is negatively associated with OT system activity in adulthood, and offer further insight into mediator and moderator effects on this link. ..
  77. Kelemenova S, Schmidtova E, Ficek A, Celec P, Kubranska A, Ostatnikova D. Polymorphisms of candidate genes in Slovak autistic patients. Psychiatr Genet. 2010;20:137-9 pubmed publisher
    ..The only significant association in autistic boys in Slovakia was found with higher number of GGC repeats in the RELN gene (P=0.001) potentially explaining lower RELN levels in blood and brain of autistic patients. ..
  78. Mileva Seitz V, Steiner M, Atkinson L, Meaney M, Levitan R, Kennedy J, et al. Interaction between oxytocin genotypes and early experience predicts quality of mothering and postpartum mood. PLoS ONE. 2013;8:e61443 pubmed publisher
    ..We examined two polymorphisms in the oxytocin peptide gene OXT (rs2740210 and rs4813627) and one polymorphism in the oxytocin receptor gene OXTR (rs237885) in 187 Caucasian ..
  79. Vanya M, Szucs S, Vetro A, Bartfai G. The potential role of oxytocin and perinatal factors in the pathogenesis of autism spectrum disorders - review of the literature. Psychiatry Res. 2017;247:288-290 pubmed publisher
    ..The aim of the present paper is to review abnormalities of oxytocin (OXT) and related congenital malformations in ASD...
  80. Wojciechowska A, Mlynarczuk J, Kotwica J. Disorders in barrier protein mRNA expression and placenta secretory activity under the influence of polychlorinated biphenyls in vitro. Theriogenology. 2017;89:9-19 pubmed publisher
    ..In addition, all three PCBs increased (P < 0.05) neurophysin I/oxytocin (NP-I/OT) mRNA expression and OT secretion but did not affect peptidyl-glycine-?-amidating ..
  81. Wood S, Tickle I, Treharne A, Pitts J, Mascarenhas Y, Li J, et al. Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding. Science. 1986;232:633-6 pubmed
    ..In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation. ..
  82. Schlesinger D, Audhya T. A comparative study of mammalian neurophysin protein sequences. FEBS Lett. 1981;128:325-8 pubmed
  83. Busnelli M, Saulière A, Manning M, Bouvier M, Gales C, Chini B. Functional selective oxytocin-derived agonists discriminate between individual G protein family subtypes. J Biol Chem. 2012;287:3617-29 pubmed publisher
    ..Functional selective ligands, activating a specific G protein signaling pathway, may possess a higher efficacy and specificity on OT-based therapeutics. ..
  84. Xu Y, Xue Y, Asan -, Daly A, Wu L, Tyler Smith C. Variation of the oxytocin/neurophysin I (OXT) gene in four human populations. J Hum Genet. 2008;53:637-43 pubmed publisher
  85. Tolson K, Gemelli T, Gautron L, Elmquist J, Zinn A, Kublaoui B. Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression. J Neurosci. 2010;30:3803-12 pubmed publisher
    ..Sim1 homozygotes and germ line Sim1 heterozygotes exhibit a remarkable decrease in hypothalamic oxytocin (Oxt) and PVN melanocortin 4 receptor (Mc4r) mRNA...
  86. Al Rawashdeh A, Kasabri V, Bulatova N, Akour A, Zayed A, Momani M, et al. The correlation between plasma levels of oxytocin and betatrophin in non-diabetic and diabetic metabolic syndrome patients: A cross sectional study from Jordan. Diabetes Metab Syndr. 2017;11:59-67 pubmed publisher
    Oxytocin (OXT) is a neurohypophyseal hormone that has been recently shown to possess a number of beneficial effects in diabetes and obesity...
  87. Campbell A. Attachment, aggression and affiliation: the role of oxytocin in female social behavior. Biol Psychol. 2008;77:1-10 pubmed
    ..Implications for understanding and researching the role of oxytocin in women's attachment, affiliation and aggression are discussed. ..
  88. Kiss I, Levy Gigi E, Keri S. CD 38 expression, attachment style and habituation of arousal in relation to trust-related oxytocin release. Biol Psychol. 2011;88:223-6 pubmed publisher
    ..These results suggest that CD38 plays a general role in oxytocin secretion, whereas habituation of arousal and attachment anxiety are specifically related to situations involving intimate trust. ..
  89. Love T, ENOCH M, Hodgkinson C, Peciña M, Mickey B, Koeppe R, et al. Oxytocin gene polymorphisms influence human dopaminergic function in a sex-dependent manner. Biol Psychiatry. 2012;72:198-206 pubmed publisher
    ..Thus, genetic variation within the oxytocin gene (OXT) is likely to explain variability in dopamine-related stress responses...
  90. Yamasue H, Kuwabara H, Kawakubo Y, Kasai K. Oxytocin, sexually dimorphic features of the social brain, and autism. Psychiatry Clin Neurosci. 2009;63:129-40 pubmed publisher
  91. Bhandari R, Bakermans Kranenburg M, van der Veen R, Parsons C, Young K, Grewen K, et al. Salivary oxytocin mediates the association between emotional maltreatment and responses to emotional infant faces. Physiol Behav. 2014;131:123-8 pubmed publisher
    ..Early emotional maltreatment might indirectly affect emotional information processing by altering the oxytonergic system. ..
  92. Binay Ã, Paketçi C, Güzel S, Samancı N. Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children. J Clin Res Pediatr Endocrinol. 2017;9:124-131 pubmed publisher
    ..Additionally, this study shows for the first time that oxytocin level is significantly lower in obese compared with non-obese children and also lower in obese children with metabolic syndrome compared to those without. ..