OX40

Summary

Gene Symbol: OX40
Description: TNF receptor superfamily member 4
Alias: ACT35, CD134, IMD16, OX40, TXGP1L, tumor necrosis factor receptor superfamily member 4, ACT35 antigen, ATC35 antigen, CD134 antigen, OX40 antigen, OX40 cell surface antigen, OX40 homologue, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor, lymphoid activation antigene ACT35, tax-transcriptionally activated glycoprotein 1 receptor
Species: human
Products:     OX40

Top Publications

  1. Bansal Pakala P, Jember A, Croft M. Signaling through OX40 (CD134) breaks peripheral T-cell tolerance. Nat Med. 2001;7:907-12 pubmed
    ..Here we show that signals from a single dose of an agonistic antibody against OX40 (CD134, a member of the tumor necrosis-factor family of receptors) can break an existing state of tolerance in the CD4+ T-..
  2. Pankow R, Durkop H, Latza U, Krause H, Kunzendorf U, Pohl T, et al. The HTLV-I tax protein transcriptionally modulates OX40 antigen expression. J Immunol. 2000;165:263-70 pubmed
    b>OX40 is a member of the TNF receptor family, expressed on activated T cells. It is the only costimulatory T cell molecule known to be specifically up-regulated in human T cell leukemia virus type-I (HTLV-I)-producing cells...
  3. Rogers P, Song J, Gramaglia I, Killeen N, Croft M. OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity. 2001;15:445-55 pubmed
    It is important to understand which molecules are essential for long-lived immunity. We show that OX40 (CD134) is required with CD28 for the survival of CD4 T cells following antigen-driven expansion...
  4. Komura K, Yoshizaki A, Kodera M, Iwata Y, Ogawa F, Shimizu K, et al. Increased serum soluble OX40 in patients with systemic sclerosis. J Rheumatol. 2008;35:2359-62 pubmed
    To determine levels of serum soluble OX40 (also termed CD134, a member of the tumor necrosis factor receptor superfamily) and their clinical associations in patients with systemic sclerosis (SSc)...
  5. Mousavi S, Soroosh P, Takahashi T, Yoshikai Y, Shen H, Lefrancois L, et al. OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells. J Immunol. 2008;181:5990-6001 pubmed
    A T cell costimulatory molecule, OX40, contributes to T cell expansion, survival, and cytokine production...
  6. So T, Choi H, Croft M. OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling. J Immunol. 2011;186:3547-55 pubmed publisher
    ..in activated or effector T cells are important, and these can be strongly influenced by signaling from OX40 (CD134), a member of the TNFR superfamily...
  7. Taylor L, Schwarz H. Identification of a soluble OX40 isoform: development of a specific and quantitative immunoassay. J Immunol Methods. 2001;255:67-72 pubmed
    OX40 (CD134) is a member of the TNF receptor family and is expressed selectively on activated T lymphocytes. Through interactions with OX40 ligand, OX40 delivers potent costimulatory signals to T cells...
  8. Wang D, Jiang W, Zhu F, Mao X, Agrawal S. Modulation of the tumor microenvironment by intratumoral administration of IMO-2125, a novel TLR9 agonist, for cancer immunotherapy. Int J Oncol. 2018;53:1193-1203 pubmed publisher
    ..antigen‑related cell adhesion molecule 1, tumor necrosis factor receptor superfamily member 4 (OX40), OX40 ligand, T‑cell immunoglobulin and mucin‑domain‑containing 3 protein, lymphocyte‑activation gene 3, ..
  9. Wu Q, Tang Y, Zhang J, Hu X, Wang Q, Huang J. [Therapeutic effects of glycyrrhizic acid on asthma airway inflammation in mice and its mechanism]. Zhonghua Yi Xue Za Zhi. 2014;94:3338-44 pubmed
    ..hematoxylin and eosin staining (HE) and the expressions of CD86, major histocompatibility complex (MHC)-II, CD40, OX40 ligand (OX40L) on CD11c(+) dendritic cells (DCs) in spleens were evaluated with flow cytometry (FCM)...

More Information

Publications138 found, 100 shown here

  1. Lin S, Cheng F, Liu J, Ye Y. Expression and Regulation of Thymic Stromal Lymphopoietin and Thymic Stromal Lymphopoietin Receptor Heterocomplex in the Innate-Adaptive Immunity of Pediatric Asthma. Int J Mol Sci. 2018;19: pubmed publisher
    ..TSLP-activated dendritic cells expressing the OX40 ligand (OX40L; CD252) trigger naive CD4? T cells to differentiate into inflammatory Th2 effector cells secreting ..
  2. Cheng H, Tay S, Wen C, Lin C, Wang A, Shih L, et al. Bioimaging of alloantigen-stimulated regulatory T cells in rat vascularized composite allotransplantation. PLoS ONE. 2018;13:e0203624 pubmed publisher
    ..The in vivo migratory pattern coincided with the altered expression of cell surface molecules of CD62L, CD103, CD134, and CD278, following donor-antigen stimulation...
  3. Gueguen C, Bouley J, Moussu H, Luce S, Duchateau M, Chamot Rooke J, et al. Changes in markers associated with dendritic cells driving the differentiation of either TH2 cells or regulatory T cells correlate with clinical benefit during allergen immunotherapy. J Allergy Clin Immunol. 2016;137:545-58 pubmed publisher
    ..At an individual patient level, DC2-associated markers, such as CD141, GATA3, OX40 ligand, and receptor-interacting serine/threonine-protein kinase 4 (RIPK4), were downregulated after a 4-month ..
  4. Gubin M, Techasintana P, Magee J, Dahm G, Calaluce R, Martindale J, et al. Conditional knockout of the RNA-binding protein HuR in CD4? T cells reveals a gene dosage effect on cytokine production. Mol Med. 2014;20:93-108 pubmed publisher
    ..in which HuR is deleted in activated T cells, we show that Th2-polarized cells from heterozygous HuR conditional (OX40-Cre HuR(fl/+)) KO mice had decreased steady-state levels of Gata3, Il4 and Il13 mRNAs with little changes at the ..
  5. Huang L, Wang M, Yan Y, Gu W, Zhang X, Tan J, et al. OX40L induces helper T cell differentiation during cell immunity of asthma through PI3K/AKT and P38 MAPK signaling pathway. J Transl Med. 2018;16:74 pubmed publisher
    ..Besides, blockade of OX40/OX40L could inhibit the proliferation of CD4+ T cells and regulate polarization of helper T cells.
  6. Rodriguez Ruiz M, Rodriguez I, Leaman O, Lopez Campos F, Montero A, Conde A, et al. Immune mechanisms mediating abscopal effects in radioimmunotherapy. Pharmacol Ther. 2019;196:195-203 pubmed publisher
    ..Immunotherapies such as immunomodulatory monoclonal antibodies (anti-PD-1, anti-CTLA-4, anti-CD137, anti-OX40, anti-CD40, anti-TGFβ), TLR-agonists, and adoptive T-cell therapy have been synergistically combined with ..
  7. Zeng M, Li Z, Ma J, Cao P, Wang H, Cui Y, et al. Clarithromycin and dexamethasone show similar anti-inflammatory effects on distinct phenotypic chronic rhinosinusitis: an explant model study. BMC Immunol. 2015;16:37 pubmed publisher
    ..of Th2 response and eosinophilia promoting molecules (thymic stromal lymphopoietin, IL-25, IL-33, CD80, CD86, OX40 ligand, programmed cell death ligand 1, CCL17, CCL22, CCL11, CCL5, IL-5, IL-13, and eosinophilic cationic protein) ..
  8. Mao R, Yang R, Chen X, Harhaj E, Wang X, Fan Y. Regnase-1, a rapid response ribonuclease regulating inflammation and stress responses. Cell Mol Immunol. 2017;14:412-422 pubmed publisher
    ..IL-12B mRNAs, thus mitigating inflammation, whereas in T cells, it restricts T-cell activation by targeting c-Rel, Ox40 and Il-2 transcripts...
  9. Peng T, Yang Y, Zhao Y, Gao J, Abbas M, Wang G, et al. [Analysis of gastric cancer tissues genome methylation by DNA methylation chip]. Zhonghua Wei Chang Wai Ke Za Zhi. 2015;18:1047-50 pubmed
    ..DNA methylation genes locate on different chromosomes, and their number and distribution vary widely. These genes may be associated with many pathways in carcinogenesis. ..
  10. Zheng R, Chen F, Gao W, Wang D, Yang Q, Wang K, et al. The TH2-polarizing function of atopic interleukin 17 receptor B-positive dendritic cells up-regulated by lipopolysaccharide. Ann Allergy Asthma Immunol. 2017;118:474-482.e1 pubmed publisher
    ..In addition, LPS increased the expression of the OX40 ligand (OX40L) but decreased inducible costimulator ligand on atopic CD86+ mo-DCs...
  11. Chen Z, Wang C, Wei F, Xu B, Liu J, Pu Y, et al. Adenovirus-mediated OX40Ig gene transfer induces long-term survival of orthotopic liver allograft in rats. Transpl Immunol. 2018;48:32-38 pubmed publisher
    ..Through OX40/OX4OL pathways, OX40Ig created an immunosuppressive effect after liver transplantation in rats...
  12. Kansy B, Hussain T, Mattheis S, Wollenberg B, Brandau S, Lang S. [Immunotherapy in head and neck cancer]. HNO. 2015;63:797-803 pubmed publisher
    ..Monoclonal antibodies directed specifically toward T cell-stimulating receptors such as CD28 and CD134, or immunosuppressive receptors CTLA-4 and PD-1, are currently under investigation and have shown promising ..
  13. Sun L, Chen C, Wu J, Dai C, Wu X. TSLP-activated dendritic cells induce T helper type 2 inflammation in Aspergillus fumigatus keratitis. Exp Eye Res. 2018;171:120-130 pubmed publisher
    ..Mature DCs can express the OX40 ligand, which has the ability to combine with OX40 on the surface of T cells to stimulate T cell proliferation...
  14. Bae J, Hideshima T, Tai Y, Song Y, Richardson P, Raje N, et al. Histone deacetylase (HDAC) inhibitor ACY241 enhances anti-tumor activities of antigen-specific central memory cytotoxic T lymphocytes against multiple myeloma and solid tumors. Leukemia. 2018;32:1932-1947 pubmed publisher
    ..ACY241 induces co-stimulatory (CD28, 41BB, CD40L, OX40) and activation (CD38) molecule expression in a dose- and time-dependent manner, and anti-tumor activities, ..
  15. Kang S, Park M, Cho M, Park S, Jang M, Yang B, et al. Parasitic nematode-induced CD4+Foxp3+T cells can ameliorate allergic airway inflammation. PLoS Negl Trop Dis. 2014;8:e3410 pubmed publisher
    ..higher levels of Treg-cell homing receptors (CCR5 and CCR9) and activation markers (Klrg1, Capg, GARP, Gzmb, OX40) than did Inf(-)Foxp3+ cells. T...
  16. Yoder A, Guo K, Dillon S, Phang T, Lee E, Harper M, et al. The transcriptome of HIV-1 infected intestinal CD4+ T cells exposed to enteric bacteria. PLoS Pathog. 2017;13:e1006226 pubmed publisher
    ..a cellular shutdown response involving the downregulation of HIV-1 reactome genes, while perturbing genes linked to OX40, PPAR and FOXO3 signaling. However, in the presence of bacteria, HIV-1 did not perturb these gene sets or pathways...
  17. Ma S, Zhang L. Elevated serum OX40L is a biomarker for identifying corticosteroid resistance in pediatric asthmatic patients. BMC Pulm Med. 2019;19:66 pubmed publisher
    ..This study aims to evaluate the serum OX40 ligand (OX40L) in pediatric asthmatic patients, and to investigated its correlations with clinical characteristics ..
  18. Tsai J, Wang H, Chiu C, Liao E. The effect of Dermatophagoides pteronyssinus group 7 allergen (Der p 7) on dendritic cells and its role in T cell polarization. Immunobiology. 2016;221:1319-28 pubmed publisher
    ..BMDCs could be activated by Der p 7 through TLR4 and DC-SIGN, and followed by the expression of OX40 ligand (OX40L) and Jagged-1, the expressions of IL4(+)/CD4(+) cells were enhanced...
  19. Roussey J, Viglianti S, Teitz Tennenbaum S, Olszewski M, Osterholzer J. Anti-PD-1 Antibody Treatment Promotes Clearance of Persistent Cryptococcal Lung Infection in Mice. J Immunol. 2017;199:3535-3546 pubmed publisher
    ..Treatment did reduce gene expression of IL-5 and IL-10 by lung leukocytes and promoted sustained upregulation of OX40 by Th1 and Th17 cells...
  20. Bae J, Samur M, Richardson P, Munshi N, Anderson K. Selective targeting of multiple myeloma by B cell maturation antigen (BCMA)-specific central memory CD8+ cytotoxic T lymphocytes: immunotherapeutic application in vaccination and adoptive immunotherapy. Leukemia. 2019;: pubmed publisher
    ..and induce highly functional BCMA-specific CTL with increased activation (CD38, CD69) and co-stimulatory (CD40L, OX40, GITR) molecule expression...
  21. Devarapu S, Grill J, Xie J, Weidenbusch M, Honarpisheh M, Vielhauer V, et al. Tumor necrosis factor superfamily ligand mRNA expression profiles differ between humans and mice during homeostasis and between various murine kidney injuries. J Biomed Sci. 2017;24:77 pubmed publisher
    ..CD95-L), TNF-related apoptosis-inducing ligand (TRAIL), TNF-related weak inducer of apoptosis (TWEAK), 4-1BBL, OX40-L (CD252) and amyloid precursor protein (APP) in healthy human and mouse solid organs...
  22. Elayeb R, Tamagne M, Bierling P, Noizat Pirenne F, Vingert B. Red blood cell alloimmunization is influenced by the delay between Toll-like receptor agonist injection and transfusion. Haematologica. 2016;101:209-18 pubmed publisher
    ..early-induced HEL-specific CD4(+) T cells was similar between groups, a high proportion of these cells expressed CD134, CD40 and CD44 in mice injected with poly(I:C) 7 days before transfusion...
  23. Mallikarjunappa S, Sargolzaei M, Brito L, Meade K, Karrow N, Pant S. Short communication: Uncovering quantitative trait loci associated with resistance to Mycobacterium avium ssp. paratuberculosis infection in Holstein cattle using a high-density single nucleotide polymorphism panel. J Dairy Sci. 2018;101:7280-7286 pubmed publisher
    ..Further functional validation of these genes is now warranted to investigate their roles in regulating the immune response and, consequently, cattle resistance to MAP infection. ..
  24. Kumar P, Bhattacharya P, Prabhakar B. A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity. J Autoimmun. 2018;95:77-99 pubmed publisher
    ..In addition to co-inhibitory receptors, co-stimulatory receptors like OX40, GITR and 4-1BB have also been widely implicated in immune homeostasis and T-cell stimulation, and use of agonistic ..
  25. Elhaï M, Avouac J, Hoffmann Vold A, Ruzehaji N, Amiar O, Ruiz B, et al. OX40L blockade protects against inflammation-driven fibrosis. Proc Natl Acad Sci U S A. 2016;113:E3901-10 pubmed publisher
    ..Immunotherapies have provided a breakthrough in the treatment of immune diseases. The glycoprotein OX40-OX40 ligand (OX40L) axis offers the advantage of a targeted approach to costimulatory signals with limited impact ..
  26. Li F, Wang Y, Lin L, Wang J, Xiao H, Li J, et al. Mast Cell-Derived Exosomes Promote Th2 Cell Differentiation via OX40L-OX40 Ligation. J Immunol Res. 2016;2016:3623898 pubmed publisher
    ..In conclusion, BMMC-exosomes promoted the proliferation and differentiation of Th2 cells via ligation of OX40L and OX40 between exosomes and T cells...
  27. Parra E, Villalobos P, Zhang J, Behrens C, Mino B, Swisher S, et al. Immunohistochemical and Image Analysis-Based Study Shows That Several Immune Checkpoints are Co-expressed in Non-Small Cell Lung Carcinoma Tumors. J Thorac Oncol. 2018;13:779-791 pubmed publisher
    ..V-set immunoregulatory receptor, T-cell immunoglobulin mucin family member 3, lymphocyte activating 3, and OX40) expressed mostly in stromal tumor-associated inflammatory cells (TAICs)...
  28. Jodeleit H, Al Amodi O, Caesar J, Villarroel Aguilera C, Holdt L, Gropp R, et al. Targeting ulcerative colitis by suppressing glucose uptake with ritonavir. Dis Model Mech. 2018;11: pubmed publisher
    ..Frequencies of CD4+ cells were significantly affected by ritonavir (CD69+ P=3E-05; CD134 P=4E-06; CD25+ P=E-07; central memory P=0...
  29. Raicevic G, Najar M, Najimi M, El Taghdouini A, van Grunsven L, Sokal E, et al. Influence of inflammation on the immunological profile of adult-derived human liver mesenchymal stromal cells and stellate cells. Cytotherapy. 2015;17:174-85 pubmed publisher
    ..for HLA class I and negative for human leukocyte antigen (HLA) class II and co-stimulatory molecules (CD80, CD86, CD134 and CD252)...
  30. Klaver E, Kuijk L, Lindhorst T, Cummings R, van Die I. Schistosoma mansoni Soluble Egg Antigens Induce Expression of the Negative Regulators SOCS1 and SHP1 in Human Dendritic Cells via Interaction with the Mannose Receptor. PLoS ONE. 2015;10:e0124089 pubmed publisher
    ..TGF-β), and the surface expression of the costimulatory molecules Programmed Death Ligand-1 (PD-L1) and OX40 ligand (OX40L), which are known phenotypic markers for the capacity of DCs to polarize naïve T cells into Th2/..
  31. Yang K, Blanco D, Neale G, Vogel P, Avila J, Clish C, et al. Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling. Nature. 2017;548:602-606 pubmed publisher
    ..regulatory molecules including the negative co-receptor PD-1 and the TNF receptor superfamily proteins GITR and OX40. Unexpectedly, LKB1 function in Treg cells was independent of conventional AMPK signalling or the mTORC1-..
  32. Stoll P, Ulrich M, Bratke K, Garbe K, Virchow J, Lommatzsch M. Imbalance of dendritic cell co-stimulation in COPD. Respir Res. 2015;16:19 pubmed publisher
    ..co-stimulatory molecule PD-L1 on pDCs and an increased expression of the pro-inflammatory co-stimulatory molecule OX40 ligand (OX40L) on mDCs...
  33. Tanabe A, Nakano K, Nakakido M, Nagatoishi S, Tanaka Y, Tsumoto K, et al. Production and characterization of a novel site-specific-modifiable anti-OX40-receptor single-chain variable fragment for targeted drug delivery. Biochem Biophys Res Commun. 2018;496:614-620 pubmed publisher
    OX40 receptor (tumor necrosis factor receptor superfamily, member 4; CD134) is a T-cell co-stimulatory molecule that plays an important role in T-cell activation and survival...
  34. Zhao J, Li W, Wang Y, Chen X. [Expression of OX40 and Bcl-2 in allergic rhinitis]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008;22:1057-9 pubmed
    To investigate the role of OX40 and Bcl-2 in allergic rhinitis(AR). Twenty-three subjects of allergic rhinitis as experimental group were collected and 20 subjects of deflection of nasal septum as control group...
  35. Gonçalves Lopes R, Lima N, Carvalho K, Scopel K, Kallas E, Ferreira M. Surface expression of inhibitory (CTLA-4) and stimulatory (OX40) receptors by CD4+ regulatory T cell subsets circulating in human malaria. Microbes Infect. 2016;18:639-648 pubmed publisher
    ..We found an increased proportion of CD4+ T cells expressing CTLA-4, OX40, GITR, TNFRII, and CD69 in acute-phase single-species infections with Plasmodium vivax, Plasmodium falciparum, or ..
  36. Nawaf M, Ulvmar M, Withers D, McConnell F, Gaspal F, Webb G, et al. Concurrent OX40 and CD30 Ligand Blockade Abrogates the CD4-Driven Autoimmunity Associated with CTLA4 and PD1 Blockade while Preserving Excellent Anti-CD8 Tumor Immunity. J Immunol. 2017;199:974-981 pubmed publisher
    ..Our work has shown that absence of OX40 and CD30 costimulatory signals prevents CD4 T cell-driven autoimmunity in Foxp3-deficient mice, suggesting a novel ..
  37. Qin W, Hongya W, Yongjing C, Fang X, Yue M, Xuekun Z, et al. Increased OX40 and soluble OX40 ligands in children with Henoch-Schonlein purpura: association with renal involvement. Pediatr Allergy Immunol. 2011;22:54-9 pubmed publisher
    ..However, the regulation of the T cells in HSP remains poorly understood. In this study, OX40/OX40L (CD134/CD252) costimulatory pathway, which could promote T-cell activation and long survival, was investigated...
  38. Hirano T, Kikuchi T, Tode N, Santoso A, Yamada M, Mitsuhashi Y, et al. OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia. EMBO Mol Med. 2016;8:422-36 pubmed publisher
    ..The role of costimulatory OX40-OX40 ligand (OX40L) interactions has been explored in the non-infectious pathology of influenza pneumonia...
  39. Chien C, Chiang B. Regulatory T cells induced by B cells: a novel subpopulation of regulatory T cells. J Biomed Sci. 2017;24:86 pubmed publisher
    ..Treg-of-B cells express LAG3, ICOS, GITR, OX40, PD1, and CTLA4 and secrete IL-10...
  40. Ma B, Mikolajczak S, Danesh A, Hosiawa K, Cameron C, Takaori Kondo A, et al. The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells. Blood. 2005;106:2002-10 pubmed
    b>OX40 and 4-1BB are members of the tumor necrosis factor (TNF) family of costimulatory receptors whose signaling is important for differential immune responses mediated by CD4+ or CD8+ T cells...
  41. Fromm G, de Silva S, Giffin L, Xu X, Rose J, Schreiber T. Gp96-Ig/Costimulator (OX40L, ICOSL, or 4-1BBL) Combination Vaccine Improves T-cell Priming and Enhances Immunity, Memory, and Tumor Elimination. Cancer Immunol Res. 2016;4:766-78 pubmed publisher
    ..secreted Fc-OX40L provided superior priming of antigen-specific CD8(+) T cells, compared with combinations with OX40 antibodies or vaccine alone...
  42. Murakami Satsutani N, Ito T, Nakanishi T, Inagaki N, Tanaka A, Vien P, et al. IL-33 Promotes the Induction and Maintenance of Th2 Immune Responses by Enhancing the Function of OX40 Ligand. Allergol Int. 2014;63:443-455 pubmed publisher
    In Th2 immune responses, TSLP is a key player by induction of OX40-ligand (OX40L) on dendritic cells (DCs), which is the trigger to induce Th2 cell-mediated allergic cascade...
  43. Metzger T, Long H, Potluri S, Pertel T, Bailey Bucktrout S, Lin J, et al. ICOS Promotes the Function of CD4+ Effector T Cells during Anti-OX40-Mediated Tumor Rejection. Cancer Res. 2016;76:3684-9 pubmed publisher
    ..ICOS signaling provided critical support for the effector function of CD4(+) Foxp3(-) T cells during anti-OX40-driven tumor immune responses...
  44. Zhao M, Li Y, Wei X, Zhang Q, Jia H, Quan S, et al. Negative immune factors might predominate local tumor immune status and promote carcinogenesis in cervical carcinoma. Virol J. 2017;14:5 pubmed publisher
    ..ligand 22/CC chemokine receptor 4), OX40L/OX40 (tumor necrosis factor superfamily member 4/tumor necrosis factor receptor superfamily member 4) and Smad3 (SMAD family member 3) in neoplastic foci and its periphery tissues from 30 ..
  45. Kim E, Lee J, Kim J, Song S, Joo D, Huh K, et al. Enhanced immune-modulatory effects of thalidomide and dexamethasone co-treatment on T cell subsets. Immunology. 2017;152:628-637 pubmed publisher
    ..Following incubation with the drugs, cells were collected and OX40, 4-1BB, and glucocorticoid-induced tumour necrosis factor receptor-related protein (GITR) expression was quantified ..
  46. Jiang H, Cui N, Yang L, Liu C, Yue L, Guo L, et al. Altered follicular helper T cell impaired antibody production in a murine model of myelodysplastic syndromes. Oncotarget. 2017;8:98270-98279 pubmed publisher
    ..The active markers (ICOS, CD40L and OX40) expressed on Tfh of NHD13 mice were decreased...
  47. Curry W, Gorrepati R, Piesche M, Sasada T, Agarwalla P, Jones P, et al. Vaccination with Irradiated Autologous Tumor Cells Mixed with Irradiated GM-K562 Cells Stimulates Antitumor Immunity and T Lymphocyte Activation in Patients with Recurrent Malignant Glioma. Clin Cancer Res. 2016;22:2885-96 pubmed publisher
    ..T-lymphocyte activation was seen with significantly increased expression of CTLA-4, PD-1, 4-1BB, and OX40 by CD4(+) cells and PD-1 and 4-1BB by CD8(+) cells...
  48. Zhao X, Sun G, Sun X, Tian D, Liu K, Liu T, et al. A novel differentiation pathway from CD4? T cells to CD4? T cells for maintaining immune system homeostasis. Cell Death Dis. 2016;7:e2193 pubmed publisher
    ..These DNT converted from CD4(+) rather than CD8(+) T cells, a process primarily regulated by OX40. DNT migrated to the liver through the CXCR3-CXCL9/CXCL10 interaction...
  49. Han J, Dakhama A, Jia Y, Wang M, Zeng W, Takeda K, et al. Responsiveness to respiratory syncytial virus in neonates is mediated through thymic stromal lymphopoietin and OX40 ligand. J Allergy Clin Immunol. 2012;130:1175-1186.e9 pubmed publisher
    Recent studies revealed a critical role for thymic stromal lymphopoietin (TSLP) released from epithelial cells and OX40 ligand (OX40L) expressed on dendritic cells (DCs) in T(H)2 priming and polarization...
  50. Reichwald K, Jørgensen T, Skov S. TL1A increases expression of CD25, LFA-1, CD134 and CD154, and induces IL-22 and GM-CSF production from effector CD4 T-cells. PLoS ONE. 2014;9:e105627 pubmed publisher
    ..together with IL-12, IL-15 and IL-18 increases expression of the co-stimulatory molecules CD154 (CD40 ligand) and CD134 (OX40) on previously activated CD4+ T cells...
  51. Wu Q, Tang Y, Hu X, Wang Q, Lei W, Zhou L, et al. Regulation of Th1/Th2 balance through OX40/OX40L signalling by glycyrrhizic acid in a murine model of asthma. Respirology. 2016;21:102-11 pubmed publisher
    ..The effect of GA on OVA-sensitized and challenged mice was investigated. The effect of GA on anti-OX40 mAb stimulated splenocytes from asthma mice model was also examined...
  52. Cook L, Munier C, Seddiki N, van Bockel D, Ontiveros N, Hardy M, et al. Circulating gluten-specific FOXP3+CD39+ regulatory T cells have impaired suppressive function in patients with celiac disease. J Allergy Clin Immunol. 2017;140:1592-1603.e8 pubmed publisher
    ..cytokine production, or proliferation but rather on antigen-induced coexpression of CD25 and OX40 (CD134)...
  53. Abo Elenein A, Shaaban D, Gheith O. Flowcytometric study of expression of perforin and CD134 in patients with systemic lupus erythematosus. Egypt J Immunol. 2008;15:135-43 pubmed
    ..b>CD134 was originally described as an activation antigen found on activated T cells...
  54. Zhao H, Xu R, Huang X, Cheng S, Huang M, Yue H, et al. Curcumin improves regulatory T cells in gut-associated lymphoid tissue of colitis mice. World J Gastroenterol. 2016;22:5374-83 pubmed publisher
    ..IL-6, IL-12 p40, IL-17 and IL-21 and the expression of costimulatory molecules (CD205, CD54 [ICAM-1], TLR4, CD252[OX40 L], CD256 [RANK] and CD254 [RANK L]) of DCs were notably inhibited in colitis mice treated with Cur...
  55. Brunn A, Mihelcic M, Carstov M, Feind L, Wieser E, Schmidt J, et al. Toll-Like Receptor 2, Toll-Like Receptor 4, Myeloid Differentiation Response Gene 88, and Toll-IL-1 Receptor Domain-Containing Adaptor-Inducing Interferon-? (TRIF) Selectively Regulate Susceptibility of P0106-125-Induced Murine Experimental Autoimmun. Am J Pathol. 2017;187:42-54 pubmed publisher
    ..Immunized TLR20/0 mice were unable to induce OX40 and OX40L by matrix metalloproteinase-2 on splenic dendritic cells...
  56. Sanmamed M, Pastor F, Rodriguez A, Perez Gracia J, Rodriguez Ruiz M, Jure Kunkel M, et al. Agonists of Co-stimulation in Cancer Immunotherapy Directed Against CD137, OX40, GITR, CD27, CD28, and ICOS. Semin Oncol. 2015;42:640-55 pubmed publisher
    ..such as CD28 or CD27 and others whose expression is induced upon recent previous antigen priming, ie, CD137, GITR, OX40, and ICOS...
  57. Rios Doria J, Durham N, Wetzel L, Rothstein R, Chesebrough J, Holoweckyj N, et al. Doxil synergizes with cancer immunotherapies to enhance antitumor responses in syngeneic mouse models. Neoplasia. 2015;17:661-70 pubmed publisher
    ..cancer immunotherapies including checkpoint blockers (anti-PD-L1, PD-1, and CTLA-4 mAbs) and TNF receptor agonists (OX40 and GITR ligand fusion proteins) in syngeneic mouse models...
  58. Aspeslagh S, Postel Vinay S, Rusakiewicz S, Soria J, Zitvogel L, Marabelle A. Rationale for anti-OX40 cancer immunotherapy. Eur J Cancer. 2016;52:50-66 pubmed publisher
    ..Among them stands OX40 (CD134), a co-stimulatory molecule that can be expressed by activated immune cells...
  59. Qian J, Zheng Y, Zheng C, Wang L, Qin H, Hong S, et al. Active vaccination with Dickkopf-1 induces protective and therapeutic antitumor immunity in murine multiple myeloma. Blood. 2012;119:161-9 pubmed publisher
    ..Furthermore, the addition of CpG as an adjuvant, or injection of B7H1-blocking or OX40-agonist Abs, further enhanced the therapeutic effects of the vaccine...
  60. Lei F, Song J, Haque R, Haque M, Xiong X, Fang D, et al. Regulation of A1 by OX40 contributes to CD8(+) T cell survival and anti-tumor activity. PLoS ONE. 2013;8:e70635 pubmed publisher
    The TNFR family member OX40 (CD134) is critical for optimal clonal expansion and survival of T cells. However, the intracellular targets of OX40 in CD8 T cells are not fully understood...
  61. Chen Y, Sun R, Wu X, Cheng M, Wei H, Tian Z. CD4+CD25+ Regulatory T Cells Inhibit Natural Killer Cell Hepatocytotoxicity of Hepatitis B Virus Transgenic Mice via Membrane-Bound TGF-β and OX40. J Innate Immun. 2016;8:30-42 pubmed publisher
    ..Furthermore, upregulated expression of membrane-bound TGF-β (mTGF-β) and OX40 on hepatic Tregs were demonstrated to account for inhibiting the NK cell-mediated hepatic injury in HBs-Tg mice ..
  62. Virani N, Thavathiru E, McKernan P, Moore K, Benbrook D, Harrison R. Anti-CD73 and anti-OX40 immunotherapy coupled with a novel biocompatible enzyme prodrug system for the treatment of recurrent, metastatic ovarian cancer. Cancer Lett. 2018;425:174-182 pubmed publisher
    ..In order to further enhance the therapeutic efficacy, anti-CD73 and anti-OX40 immunostimulants were combined with mCTH-ANXA5, resulting in an increase of survival by 100% from 12 to 24 days ..
  63. Kashiwakura J, Yokoi H, Saito H, Okayama Y. T cell proliferation by direct cross-talk between OX40 ligand on human mast cells and OX40 on human T cells: comparison of gene expression profiles between human tonsillar and lung-cultured mast cells. J Immunol. 2004;173:5247-57 pubmed
    ..higher expression levels for CC chemokines (CCL3 and 4), which recruit T cells, and for TNFR superfamilies (OX40 ligand and 4-1BB ligand), which induce proliferation of T cells...
  64. Lan P, Fan Y, Zhao Y, Lou X, Monsour H, Zhang X, et al. TNF superfamily receptor OX40 triggers invariant NKT cell pyroptosis and liver injury. J Clin Invest. 2017;127:2222-2234 pubmed publisher
    ..Here we have found that liver iNKT cells constitutively express the costimulatory TNF superfamily receptor OX40 and that OX40 stimulation results in massive pyroptotic death of iNKT cells, characterized by the release of potent ..
  65. Cepowicz D, Gryko M, Zaręba K, Stasiak Bermuta A, Kędra B. Assessment of activity of an adhesion molecule CD134 and CD137 in colorectal cancer patients. Pol Przegl Chir. 2011;83:641-5 pubmed publisher
    ..THE AIM OF THE STUDY was to determine expression of adhesion molecules CD134 and CD137 in the peripheral blood in colorectal cancer patients, depending on clinical cancer stage, size and ..
  66. Xiao X, Shi X, Fan Y, Wu C, Zhang X, Minze L, et al. The Costimulatory Receptor OX40 Inhibits Interleukin-17 Expression through Activation of Repressive Chromatin Remodeling Pathways. Immunity. 2016;44:1271-83 pubmed publisher
    ..Here we found that stimulation of OX40 triggered a robust chromatin remodeling response and produced a "closed" chromatin structure at interleukin-17 (IL-..
  67. Hanieh H, Masuda K, Metwally H, Chalise J, Mohamed M, Nyati K, et al. Arid5a stabilizes OX40 mRNA in murine CD4+ T cells by recognizing a stem-loop structure in its 3'UTR. Eur J Immunol. 2017;: pubmed publisher
    ..Here, we show that the levels of Arid5a and OX40 are correlated in CD4+ T cells under Th17 conditions in an IL-6-dependent manner...
  68. Golovina T, Mikheeva T, Suhoski M, Aqui N, Tai V, Shan X, et al. CD28 costimulation is essential for human T regulatory expansion and function. J Immunol. 2008;181:2855-68 pubmed
    ..Using cell-based artificial APCs we found that CD28 but not ICOS, OX40, 4-1BB, CD27, or CD40 ligand costimulation maintained high levels of Foxp3 expression and in vitro suppressive ..
  69. Kim B, Kim J, Kim E, Lee J, Joo D, Huh K, et al. Role of Thalidomide on the Expression of OX40, 4-1BB, and GITR in T Cell Subsets. Transplant Proc. 2016;48:1270-4 pubmed publisher
    ..Here we examined the changes in the expression of tumor necrosis factor receptor superfamilies (TNFRSFs), including OX40, 4-1BB, and glucocorticoid-induced TNFR-related protein (GITR) in T cell subsets by TM treatments...
  70. Buchan S, Rogel A, Al Shamkhani A. The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy. Blood. 2017;: pubmed publisher
    ..We here review the immunobiology of two particularly promising TNFRSF target receptors, CD27 and OX40, and their respective ligands CD70 and OX40L, focusing on their role within a tumor setting...
  71. Cho S, Kim J, Ryu H, Kim J, Kim H, Park J, et al. Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population. Hum Immunol. 2004;65:710-8 pubmed
    ..90, p < 0.001). The validated SNPs in the TNF-TNFR superfamily would be valuable for association studies with several immune-mediated human diseases. ..
  72. Webb G, Hirschfield G, Lane P. OX40, OX40L and Autoimmunity: a Comprehensive Review. Clin Rev Allergy Immunol. 2016;50:312-32 pubmed publisher
    The tumour necrosis factor receptor OX40 (CD134) is activated by its cognate ligand OX40L (CD134L, CD252) and functions as a T cell co-stimulatory molecule...
  73. Dempke W, Fenchel K, Uciechowski P, Dale S. Second- and third-generation drugs for immuno-oncology treatment-The more the better?. Eur J Cancer. 2017;74:55-72 pubmed publisher
    ..g. TIM-3, VISTA, LAG-3, IDO, KIR) and newly developed co-stimulatory antibodies (e.g. CD40, GITR, OX40, CD137, ICOS)...
  74. Wang Y, Li G, Fu Y, Wang H, Shen Z. Blockade of OX40/OX40 ligand to decrease cytokine messenger RNA expression in acute renal allograft rejection in vitro. Transplant Proc. 2013;45:2565-8 pubmed publisher
    ..by peripheral blood mononuclear cells (PBMCs) from renal recipients experiencing acute rejection by blocking OX40-OX40L interactions with recombinant human OX40-Fc fusion protein (rhOX40Fc) in vitro...
  75. Kumari A, Garnett Benson C. Effector function of CTLs is increased by irradiated colorectal tumor cells that modulate OX-40L and 4-1BBL and is reversed following dual blockade. BMC Res Notes. 2016;9:92 pubmed publisher
    ..Overall, results of this study suggest that, beyond simply rendering tumor cells more sensitive to immune attack, radiation can be used to specifically modulate expression of genes that directly stimulate effector T cell activity. ..
  76. Li J, Li L, Shang X, Benson J, Merle Elloso M, Schantz A, et al. Negative regulation of IL-17 production by OX40/OX40L interaction. Cell Immunol. 2008;253:31-7 pubmed publisher
    ..OX40 ligand (OX40L) is an early-stage activator of T-cells through its interaction with CD134 (OX40) that is up-regulated on antigen challenged T-cells...
  77. Dumitriu I, Baruah P, Finlayson C, Loftus I, Antunes R, Lim P, et al. High levels of costimulatory receptors OX40 and 4-1BB characterize CD4+CD28null T cells in patients with acute coronary syndrome. Circ Res. 2012;110:857-69 pubmed publisher
    ..Expression of alternative costimulatory receptors (inducible costimulator, OX40, 4-1BB, cytotoxic T lymphocyte associated antigen-4, programmed death-1) was quantified in CD4(+)CD28(null) T cells ..
  78. Saito M, Tanaka R, Arishima S, Matsuzaki T, Ishihara S, Tokashiki T, et al. Increased expression of OX40 is associated with progressive disease in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. Retrovirology. 2013;10:51 pubmed publisher
    b>OX40 is a member of the tumor necrosis factor receptor family that is expressed primarily on activated CD4+ T cells and promotes the development of effector and memory T cells...
  79. Jacquemin C, Schmitt N, Contin Bordes C, Liu Y, Narayanan P, Seneschal J, et al. OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response. Immunity. 2015;42:1159-70 pubmed publisher
    ..However, the mechanisms that cause aberrant Tfh cell responses in SLE remain elusive. Here we showed the OX40 ligand (OX40L)-OX40 axis contributes to the aberrant Tfh response in SLE...
  80. Kunihiro M, Fujii H, Miyagi T, Takahashi Y, Tanaka R, Fukushima T, et al. Heat Shock Enhances the Expression of the Human T Cell Leukemia Virus Type-I (HTLV-I) Trans-Activator (Tax) Antigen in Human HTLV-I Infected Primary and Cultured T Cells. Viruses. 2016;8: pubmed publisher
    ..As expected, HS resulted in enhanced expression of the Tax-inducible host antigens, such as CD83 and OX40. Finally, we confirmed that HS enhanced the levels of Tax and gp46 antigen expression in primary human CD4? T cells ..
  81. Tuncel J, Haag S, Holmdahl R. MHC class II alleles associated with Th1 rather than Th17 type immunity drive the onset of early arthritis in a rat model of rheumatoid arthritis. Eur J Immunol. 2017;47:563-574 pubmed publisher
    ..Moreover, upon pristane injection, these strains exhibited more Ag-primed OX40+ and proliferating T cells of polyclonal origin...
  82. Brezar V, Hani L, Surenaud M, Hubert A, Lacabaratz C, Lelievre J, et al. Negative modulation of suppressive HIV-specific regulatory T cells by IL-2 adjuvanted therapeutic vaccine. PLoS Pathog. 2017;13:e1006489 pubmed publisher
    ..IL-2 administration increased significantly HIV-specific CD4+CD25+CD134+ T-cell responses, which inversely correlated with viral load after TI (r = -0.7, p <0...
  83. Alharshawi K, Marinelarena A, Kumar P, El Sayed O, Bhattacharya P, Sun Z, et al. PKC-ѳ is dispensable for OX40L-induced TCR-independent Treg proliferation but contributes by enabling IL-2 production from effector T-cells. Sci Rep. 2017;7:6594 pubmed publisher
    We have previously shown that OX40L/OX40 interaction is critical for TCR-independent selective proliferation of Foxp3+ Tregs, but not Foxp3- effector T-cells (Teff), when CD4+ T-cells are co-cultured with ..
  84. de Parseval A, Chatterji U, Morris G, Sun P, Olson A, Elder J. Structural mapping of CD134 residues critical for interaction with feline immunodeficiency virus. Nat Struct Mol Biol. 2005;12:60-6 pubmed
    b>CD134 is a primary binding receptor for feline immunodeficiency virus (FIV), and with CXCR4 facilitates infection of CD4(+) T cells. Human CD134 fails to support FIV infection...
  85. Ria M, Eriksson P, Boquist S, Ericsson C, Hamsten A, Lagercrantz J. Human genetic evidence that OX40 is implicated in myocardial infarction. Biochem Biophys Res Commun. 2006;339:1001-6 pubmed
    ..A number of studies also suggest a possible role for OX40 (the OX40L receptor) as a factor contributing to atherosclerosis...
  86. Endl J, Rosinger S, Schwarz B, Friedrich S, Rothe G, Karges W, et al. Coexpression of CD25 and OX40 (CD134) receptors delineates autoreactive T-cells in type 1 diabetes. Diabetes. 2006;55:50-60 pubmed
    ..T-cells of patients could be distinguished from those of control subjects by their coexpression of CD25 and CD134. Autoantigen-specific T-cells that recognized multiple GAD65- and preproinsulin-derived peptides and coexpressed ..
  87. Hippen K, Harker Murray P, Porter S, Merkel S, Londer A, Taylor D, et al. Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells. Blood. 2008;112:2847-57 pubmed publisher
    ..Despite the high expansion and in contrast to studies using other Treg sources, neither OX40 nor 4-1BB signaling of UCB Tregs reduced in vitro suppression...
  88. Kimman T, Banus S, Reijmerink N, Reimerink J, Stelma F, Koppelman G, et al. Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination. PLoS ONE. 2008;3:e3665 pubmed publisher
    ..Fine tuning of interacting proteins in the TLR pathway appears important for the induction of an optimal vaccine response. ..
  89. Piconese S, Timperi E, Pacella I, Schinzari V, Tripodo C, Rossi M, et al. Human OX40 tunes the function of regulatory T cells in tumor and nontumor areas of hepatitis C virus-infected liver tissue. Hepatology. 2014;60:1494-507 pubmed publisher
    ..one side, cirrhotic and tumor fragments were moderately and highly infiltrated by Tregs, respectively, expressing OX40 and a T-bethigh IFN-?- "T-helper (Th)1-suppressing" phenotype; on the other side, noncirrhotic liver ..
  90. Zander R, Obeng Adjei N, Guthmiller J, Kulu D, Li J, Ongoiba A, et al. PD-1 Co-inhibitory and OX40 Co-stimulatory Crosstalk Regulates Helper T Cell Differentiation and Anti-Plasmodium Humoral Immunity. Cell Host Microbe. 2015;17:628-41 pubmed publisher
    ..that malaria patients and Plasmodium-infected rodents exhibit atypical expression of the co-stimulatory receptor OX40 on CD4 T cells and that therapeutic enhancement of OX40 signaling enhances helper CD4 T cell activity, humoral ..
  91. Lai C, August S, Albibas A, Behar R, Cho S, Polak M, et al. OX40+ Regulatory T Cells in Cutaneous Squamous Cell Carcinoma Suppress Effector T-Cell Responses and Associate with Metastatic Potential. Clin Cancer Res. 2016;22:4236-48 pubmed publisher
    ..0186, n = 11 tumors). The costimulatory molecule OX40 was expressed predominantly on tumoral Tregs (P < 0...
  92. Kumai T, Lee S, Cho H, Sultan H, Kobayashi H, Harabuchi Y, et al. Optimization of Peptide Vaccines to Induce Robust Antitumor CD4 T-cell Responses. Cancer Immunol Res. 2017;5:72-83 pubmed publisher
    ..of generating vast CD4 T-cell responses by combining synthetic peptides with toll-like receptor (TLR) agonists and OX40/CD40 costimulation...