Gene Symbol: osterix
Description: Sp7 transcription factor
Alias: OI11, OI12, OSX, osterix, transcription factor Sp7, zinc finger protein osterix
Species: human
Products:     osterix

Top Publications

  1. Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng J, Behringer R, et al. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell. 2002;108:17-29 pubmed
    We have identified a novel zinc finger-containing transcription factor, called Osterix (Osx), that is specifically expressed in all developing bones. In Osx null mice, no bone formation occurs...
  2. Sinha K, Yasuda H, Coombes M, Dent S, de Crombrugghe B. Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase. EMBO J. 2010;29:68-79 pubmed publisher
    b>Osterix (Osx) is an osteoblast-specific transcription factor required for osteoblast differentiation and bone formation...
  3. Gao Y, Jheon A, Nourkeyhani H, Kobayashi H, Ganss B. Molecular cloning, structure, expression, and chromosomal localization of the human Osterix (SP7) gene. Gene. 2004;341:101-10 pubmed
    We report the isolation of the human orthologue of the mouse Osterix (Osx/Sp7) gene, a C2H2 zinc finger transcription factor of the SP gene family and putative "master" regulator of bone cell differentiation...
  4. Liu L, Zhou L, Yang X, Liu Q, Yang L, Zheng C, et al. 17?-estradiol attenuates ovariectomy?induced bone deterioration through the suppression of the ephA2/ephrinA2 signaling pathway. Mol Med Rep. 2017;: pubmed publisher
    ..In conclusion, E2 can attenuate OVX?induced bone deterioration partially through the suppression of the ephA2/ephrinA2 signaling pathway. Therefore EphA2/ephrinA2 signaling pathway may be a potential target for osteoporosis treatment...
  5. Yang L, Liu S, Mu S, Man X, Ba G, Guo R, et al. Leonurine hydrochloride promotes osteogenic differentiation and increases osteoblastic bone formation in ovariectomized mice by Wnt/β-catenin pathway. Biochem Biophys Res Commun. 2018;504:941-948 pubmed publisher
    ..Moreover, LH upregulated osteogenesis-related gene expression, including osterix, alpha 1 type 1 collagen, runt-related transcription factor 2 (Runx2) and ALP, as shown by quantitative reverse ..
  6. Jing Z, Wang C, Yang Q, Wei X, Jin Y, Meng Q, et al. Luteolin attenuates glucocorticoid-induced osteoporosis by regulating ERK/Lrp-5/GSK-3β signaling pathway in vivo and in vitro. J Cell Physiol. 2019;234:4472-4490 pubmed publisher
    ..expression and mRNA expression levels of osteogenic markers, including runt-related transcription factor 2, osterix, collagen type I, and osteocalcin...
  7. Lam A, Sim E, Shekaran A, Li J, Teo K, Goggi J, et al. Sub-confluent culture of human mesenchymal stromal cells on biodegradable polycaprolactone microcarriers enhances bone healing of rat calvarial defect. Cytotherapy. 2019;: pubmed publisher
    ..early osteoblast genes Runt-related transcription factor 2 (RUNX2), Alkaline phosphatase (ALP), collagen type I, osterix and osteocalcin); and (v) in vivo implantation of biodegradable LPCL MCs covered with 50% heMSCs into rats with ..
  8. Shao J, Liu Z, Wang L, Song Z, Chang H, Han N, et al. Screening of the optimized prescription from Suqingwan in terms of its therapeutic effect on DSS-induced ulcerative colitis by its regulation of inflammatory and oxidative mediators. J Ethnopharmacol. 2017;202:54-62 pubmed publisher
    ..SP8 displayed a similar anti-ulcerative colitis activity to SQW, and its in vivo mechanism of action is related to up-regulation of anti-inflammatory cytokines and down-regulation of pro-inflammatory and oxidative factors. ..
  9. Föger Samwald U, Vekszler G, Hörz Schuch E, Salem S, Wipperich M, Ritschl P, et al. Molecular mechanisms of osteoporotic hip fractures in elderly women. Exp Gerontol. 2016;73:49-58 pubmed publisher
    ..We could show a significantly decreased expression of the osteoblast related genes RUNX2, Osterix, Sclerostin, WNT10B, and Osteocalcin, a significantly increased ratio of RANKL to Osteoprotegerin, and a ..

More Information

Publications151 found, 100 shown here

  1. Hui T, A P, Zhao Y, Wang C, Gao B, Zhang P, et al. EZH2, a potential regulator of dental pulp inflammation and regeneration. J Endod. 2014;40:1132-8 pubmed publisher
    ..binding protein a (CEBP/a) mRNA in adipogenic induction while enhancing alkaline phosphatase activity, Osx, and bone sialoprotein (BSP) mRNA in mineralization induction of HDPCs...
  2. Rai A, Singh S, Dwivedi S, Srivastava A, Pandey P, Kumar S, et al. Catalase Expression in Azospirillum brasilense Sp7 Is Regulated by a Network Consisting of OxyR and Two RpoH Paralogs and Including an RpoE1→RpoH5 Regulatory Cascade. Appl Environ Microbiol. 2018;84: pubmed publisher
    ..brasilense Sp7. Our work gives a glimpse of systems biology of A. brasilense used for responding to oxidative stress. ..
  3. Le P, Bishop K, Maridas D, Motyl K, Brooks D, Nagano K, et al. Spontaneous mutation of Dock7 results in lower trabecular bone mass and impaired periosteal expansion in aged female Misty mice. Bone. 2017;105:103-114 pubmed publisher
    ..These studies establish Dock7 as a critical regulator of both cortical and trabecular bone mass, and demonstrate for the first time a novel role of Dock7 in modulating compensatory changes in the periosteum with aging. ..
  4. Yu X, Liu S, Wang W, Li S. Periodontal ligament?associated protein?1 delays rat periodontal bone defect repair by regulating osteogenic differentiation of bone marrow stromal cells and osteoclast activation. Int J Mol Med. 2018;41:1110-1118 pubmed publisher
    ..including alkaline phosphatase (ALP), bone sialoprotein (BSP), runt-related transcription factor 2 (Runx2), Osterix (Osx) and osteocalcin (OC), as indicators of rBMSC?induced osteogenesis, were examined by RT-qPCR and western ..
  5. Wang J, Wang G, Gong L, Sun G, Shi B, Bao H, et al. Isopsoralen regulates PPAR??/WNT to inhibit oxidative stress in osteoporosis. Mol Med Rep. 2018;17:1125-1131 pubmed publisher
    ..Isopsoralen also promoted the activity of alkaline phosphatase and the mRNA expression levels of Col 1, osterix and osteopontin in mice with postmenopausal osteoporosis...
  6. Zhang J, Zhang W, Dai J, Wang X, Shen S. Overexpression of Dlx2 enhances osteogenic differentiation of BMSCs and MC3T3-E1 cells via direct upregulation of Osteocalcin and Alp. Int J Oral Sci. 2019;11:12 pubmed publisher
    ..had little impact on the expression level of the pivotal osteogenic transcription factors Runx2, Dlx5, Msx2, and Osterix, but led to upregulation of Alp and Osteocalcin (OCN), both of which play critical roles in promoting osteoblast ..
  7. Xiao L, Esliger A, Hurley M. Nuclear fibroblast growth factor 2 (FGF2) isoforms inhibit bone marrow stromal cell mineralization through FGF23/FGFR/MAPK in vitro. J Bone Miner Res. 2013;28:35-45 pubmed publisher
    ..mRNA levels for the osteoblast-related genes, osteocalcin, Runt-related transcription factor 2 (Runx2), and osterix, and the osteocyte-related gene dentin matrix acidic phosphoprotein 1 (Dmp1) were significantly decreased in HMW ..
  8. Foster B, Ao M, Willoughby C, Soenjaya Y, Holm E, Lukashova L, et al. Mineralization defects in cementum and craniofacial bone from loss of bone sialoprotein. Bone. 2015;78:150-64 pubmed publisher
    ..Immunostaining and PCR demonstrated that osteoblast markers, osterix, alkaline phosphatase, and osteopontin were unchanged in Bsp null mandibles compared to WT...
  9. Meyer M, Benkusky N, Pike J. Selective Distal Enhancer Control of the Mmp13 Gene Identified through Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) Genomic Deletions. J Biol Chem. 2015;290:11093-107 pubmed publisher
    ..factors such as Runt-related transcription factor 2 (RUNX2), CCAAT/enhancer-binding protein β (C/EBPβ), OSX, and vitamin D receptor (VDR)...
  10. Tsao Y, Shih Y, Liu Y, Liu Y, Lee O. Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells. Stem Cell Res Ther. 2017;8:39 pubmed publisher
    ..Early osteogenic marker genes including osterix, alkaline phosphatase, and type I collagen were significantly downregulated in MSCs under high concentration of ..
  11. Fu C, Zhang X, Ye F, Yang J. High insulin levels in KK-Ay diabetic mice cause increased cortical bone mass and impaired trabecular micro-structure. Int J Mol Sci. 2015;16:8213-26 pubmed publisher
    ..both osteoblast-related genes, such as osteocalcin (OC), bone sialoprotein, Type I Collagen, osteonectin, RUNX2 and OSX, and osteoclast-related genes, such as TRAP and TCIRG, were up-regulated in KK-Ay mice...
  12. Su X, Zou X, Chen Q, Zeng Y, Shao Y, He B, et al. Follicle-Stimulating Hormone β-Subunit Potentiates Bone Morphogenetic Protein 9-Induced Osteogenic Differentiation in Mouse Embryonic Fibroblasts. J Cell Biochem. 2017;118:1792-1802 pubmed publisher
    ..BMP9-induced alkaline phosphatase activity (ALP), the expression of osteogenic transcriptional factors, Runx2 and Osx, and the established late osteogenic markers, osteopontin (OPN) and osteocalcin (OCN), so does the ectopic bone ..
  13. Ali D, Hamam R, Alfayez M, Kassem M, Aldahmash A, Alajez N. Epigenetic Library Screen Identifies Abexinostat as Novel Regulator of Adipocytic and Osteoblastic Differentiation of Human Skeletal (Mesenchymal) Stem Cells. Stem Cells Transl Med. 2016;5:1036-47 pubmed publisher
    ..Manipulating such pathways allows a novel use for epigenetic compounds in hMSC-based therapies for tissue engineering, bone disease, obesity, and metabolic-disorders. ..
  14. Pan J, Wang J, Hao L, Zhu G, Nguyen D, Li Q, et al. The Triple Functions of D2 Silencing in Treatment of Periapical Disease. J Endod. 2017;43:272-278 pubmed publisher
    ..reducing bone resorption with 75% protection through reducing osteoclasts, enhancing bone formation by increasing osterix expression, and inhibiting inflammation by decreasing T-cell infiltration...
  15. Urano Morisawa E, Takami M, Suzawa T, Matsumoto A, Osumi N, Baba K, et al. Induction of osteoblastic differentiation of neural crest-derived stem cells from hair follicles. PLoS ONE. 2017;12:e0174940 pubmed publisher
    ..Cells stimulated with bone morphogenetic protein-2 expressed osteocalcin, osterix, and alkaline phosphatase mRNA, resulting in production of mineralized matrices, which were detected by von Kossa ..
  16. Zhang D, Bae C, Lee J, Lee J, Jin Z, Kang M, et al. The bone anabolic effects of irisin are through preferential stimulation of aerobic glycolysis. Bone. 2018;114:150-160 pubmed publisher
    ..of osteoblast-specific transcriptional factors, including Runt-related transcription factor-2 (Runx2), Oster (Osx), as well as early osteoblastic differentiation markers such as alkaline phosphatase (Alp) and collagen type I ..
  17. Harada K, Harada T, Ferdous T, Takenawa T, Ueyama Y. Osteogenic cell fractions isolated from mouse tongue muscle. Mol Med Rep. 2015;12:31-6 pubmed publisher
    ..The expression of osteogenic markers (Runx2, osterix, alkaline phosphatase, fibronectin, osteocalcin, osteonectin and osteopontin) was investigated in cultured TDSCs ..
  18. Joshi S, Clapp W, Wang W, Khan S. Osteogenic changes in kidneys of hyperoxaluric rats. Biochim Biophys Acta. 2015;1852:2000-12 pubmed publisher
    ..Genes for runt related transcription factors (RUNX1 and 2), zinc finger protein Osterix, bone morphogenetic proteins (BMP2 and 7), bone morphogenetic protein receptor (BMPR2), collagen, ..
  19. Metzger C, Brezicha J, Elizondo J, Narayanan S, Hogan H, Bloomfield S. Differential responses of mechanosensitive osteocyte proteins in fore- and hindlimbs of hindlimb-unloaded rats. Bone. 2017;105:26-34 pubmed publisher
    ..b>Osterix surface, a marker of osteoblasts, was lower in HU in the distal femur; however, the proximal humerus had more %..
  20. Huang H, Wang J, Zhang Y, Zhu G, Li Y, Ping J, et al. Bone resorption deficiency affects tooth root development in RANKL mutant mice due to attenuated IGF-1 signaling in radicular odontoblasts. Bone. 2018;114:161-171 pubmed publisher
    ..Reduced expression of nuclear factor I C (NFIC), osterix, and dentin sialoprotein, markers essential for radicular (root) odontogenic cell differentiation indicated that ..
  21. Papachristou N, Blair H, Kalyvioti E, Syggelos S, Karavia E, Kontogeorgakos V, et al. Western-type diet differentially modulates osteoblast, osteoclast, and lipoblast differentiation and activation in a background of APOE deficiency. Lab Invest. 2018;98:1516-1526 pubmed publisher
    ..of both animal groups showed that APOE null mice had significantly reduced levels of the osteoblastic (RUNX2 and Osterix) and lipoblastic (PPARγ and CEBPα) cardinal regulators...
  22. Kishi Y, Fujihara H, Kawaguchi K, Yamada H, Nakayama R, Yamamoto N, et al. PARP Inhibitor PJ34 Suppresses Osteogenic Differentiation in Mouse Mesenchymal Stem Cells by Modulating BMP-2 Signaling Pathway. Int J Mol Sci. 2015;16:24820-38 pubmed publisher
    ..PJ34 suppressed mRNA induction of osteogenic markers, such as Runx2, Osterix, Bone Morphogenetic Protein-2, Osteocalcin, bone sialoprotein, and Osteopontin, and protein levels of Bone ..
  23. Kim J, Kim D, Auh Q, Yi J, Moon S, Kim E. Role of Protein Phosphatase 1 in Angiogenesis and Odontoblastic Differentiation of Human Dental Pulp Cells. J Endod. 2017;43:417-424 pubmed publisher
    ..protein 2, phosphorylation of Smad 1/5/8, and mRNA expression of runt-related transcription factor 2 and osterix. This study provides the first evidence that PP1 might be a potent regulator of developing pulp tissue in vivo ..
  24. Teves M, Sundaresan G, Cohen D, Hyzy S, Kajan I, Maczis M, et al. Spag17 deficiency results in skeletal malformations and bone abnormalities. PLoS ONE. 2015;10:e0125936 pubmed publisher
    ..Micro-CTs and von Kossa staining demonstrated increased mineral in the femur. Moreover, osteocalcin and osterix were more highly expressed in mutant mice than in wild-type mice femurs...
  25. Park O, Kim J, Yang J, Yun C, Han S. Enterococcus faecalis Inhibits Osteoblast Differentiation and Induces Chemokine Expression. J Endod. 2015;41:1480-5 pubmed publisher
    ..HKEF also decreased the expression of Runx2, osterix, β-catenin, osteocalcin, and type I collagen...
  26. Gioia R, Panaroni C, Besio R, Palladini G, Merlini G, Giansanti V, et al. Impaired osteoblastogenesis in a murine model of dominant osteogenesis imperfecta: a new target for osteogenesis imperfecta pharmacological therapy. Stem Cells. 2012;30:1465-76 pubmed publisher
    ..This is the first report of impaired MSC differentiation to osteoblasts in OI, and it identifies a new potential target for the pharmacological treatment of the disorder. ..
  27. Al Mamun M, Hosen M, Islam K, Khatun A, Alam M, Al Bari M. Tridax procumbens flavonoids promote osteoblast differentiation and bone formation. Biol Res. 2015;48:65 pubmed publisher
    ..TPFs also upregulated osteoblast differentiation related genes, including osteocalcin, osterix, and Runx2 in primary osteoblasts...
  28. Del Real A, Perez Campo F, Fernandez A, Sañudo C, Ibarbia C, Pérez Núñez M, et al. Differential analysis of genome-wide methylation and gene expression in mesenchymal stem cells of patients with fractures and osteoarthritis. Epigenetics. 2017;12:113-122 pubmed publisher
    ..hMSCs from patients with fractures showed enhanced proliferation and upregulation of the osteogenic drivers RUNX2/OSX. Also, they showed some signs of accelerated methylation aging...
  29. Zhang C, Chen Z, Meng X, Li M, Zhang L, Huang A. The involvement and possible mechanism of pro-inflammatory tumor necrosis factor alpha (TNF-?) in thoracic ossification of the ligamentum flavum. PLoS ONE. 2017;12:e0178986 pubmed publisher
    ..On the other hand, osteoblast differentiation related genes such as Bmp2 and Osterix (Osx) were upregulated in the presence of TNF-?. TNF-? activated Osx expression in a dose-dependent manner...
  30. Torii D, Tsutsui T, Watanabe N, Konishi K. Bone morphogenetic protein 7 induces cementogenic differentiation of human periodontal ligament-derived mesenchymal stem cells. Odontology. 2016;104:1-9 pubmed publisher
    ..On the other hand, we found that transcription of Sp7/Osterix and PTPLA/CAP was up-regulated after 1 week of BMP-7 treatment on purified normal human PDL cells as a result of ..
  31. Wang L, Lu W, Shi J, Zhang H, Xu X, Gao B, et al. Anti?osteoporotic effects of tetramethylpyrazine via promoting osteogenic differentiation and inhibiting osteoclast formation. Mol Med Rep. 2017;16:8307-8314 pubmed publisher
    ..The immunostaining of osterix (OSX) and tartrate?resistant acid phosphatase (TRAP) staining indicated that TMP promoted osteogenesis and ..
  32. Xiao L, Andemariam B, Taxel P, Adams D, Zempsky W, Dorcelus V, et al. Loss of Bone in Sickle Cell Trait and Sickle Cell Disease Female Mice Is Associated With Reduced IGF-1 in Bone and Serum. Endocrinology. 2016;157:3036-46 pubmed publisher
    ..Collagen-I mRNA was significantly decreased in tibiae from SCT and SCD and osterix, Runx2, osteoclacin, and Dmp-1 mRNA were significantly decreased in tibiae of SCD compared with control...
  33. Li D, He C, Liu F, Li J, Gao J, Li Y, et al. Annexin A2, up-regulated by IL-6, promotes the ossification of ligament fibroblasts from ankylosing spondylitis patients. Biomed Pharmacother. 2016;84:674-679 pubmed publisher
    ..of proteins associated with osteogenic differentiation, including bone morphogenetic protein-2, osteocalcin and osterix, and the ratio of osteoprotegerin to receptor activator of NF-?B ligand...
  34. Zhang F, Rong Z, Wang Z, Zhang Z, Sun D, Dong S, et al. Periostin promotes ectopic osteogenesis of CTLA4-modified bone marrow mesenchymal stem cells. Cell Tissue Res. 2017;370:143-151 pubmed publisher
    ..osteogenic marker expression in MSCs, including runt-related transcription factor 2, collagen 1, osteocalcin, osterix, and alkaline phosphatase and calcium nodule formation...
  35. Peters S, Wang Y, Serra R. Tgfbr2 is required in osterix expressing cells for postnatal skeletal development. Bone. 2017;97:54-64 pubmed publisher
    ..To study the role of Tgfbr2 in immature osteoblasts, we generated Osx-Cre;Tgfbr2fl/fl mice and found defects in the postnatal development of the skull vault and long bones as ..
  36. Li S, Xu W, Xing Z, Qian J, Chen L, Gu R, et al. A Conditional Knockout Mouse Model Reveals a Critical Role of PKD1 in Osteoblast Differentiation and Bone Development. Sci Rep. 2017;7:40505 pubmed publisher
    ..confirmed by Micro-CT and histological staining as well as expression of osteoblastic marker (OPN, Runx2 and OSX)...
  37. Miyauchi S, Kitagaki J, Masumoto R, Imai A, Kobayashi K, Nakaya A, et al. Sphingomyelin Phosphodiesterase 3 Enhances Cytodifferentiation of Periodontal Ligament Cells. J Dent Res. 2017;96:339-346 pubmed publisher
    ..expression of calcification-related genes, such as alkaline phosphatase (ALPase), type I collagen, osteopontin, Osterix (Osx), and runt-related transcription factor (Runx)-2 in HPDL cells...
  38. Withers C, Brown D, Byiringiro I, Allen M, Condon K, Satin J, et al. Rad GTPase is essential for the regulation of bone density and bone marrow adipose tissue in mice. Bone. 2017;103:270-280 pubmed publisher
    ..Microarray analysis revealed that canonical osteogenic gene expression (Runx2, osterix, etc...
  39. Choi E, Suh K, Jung W, Park S, Chin S, Rhee S, et al. Actein alleviates 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated cellular dysfunction in osteoblastic MC3T3-E1 cells. Environ Toxicol. 2017;32:2455-2470 pubmed publisher
    ..genes associated with osteoblastic differentiation (ALP, type I collagen, osteoprotegerin, bone sialoprotein, and osterix)...
  40. Li J, Cui Y, Xu J, Wang Q, Yang X, Li Y, et al. Suppressor of Fused restraint of Hedgehog activity level is critical for osteogenic proliferation and differentiation during calvarial bone development. J Biol Chem. 2017;292:15814-15825 pubmed publisher
    ..We show that there is suppression of Runx2 and Osterix, the osteogenic regulators, in calvarial mesenchyme in the Sufu mutant...
  41. Mata A, Pacheco C, Cruz Pérez J, Sáenz M, Baca B. In silico comparative analysis of GGDEF and EAL domain signaling proteins from the Azospirillum genomes. BMC Microbiol. 2018;18:20 pubmed publisher
  42. Lee S, Jeong H, Han Y, Cheong H, Kang B, Lee K. Prolyl isomerase Pin1 regulates the osteogenic activity of Osterix. Mol Cell Endocrinol. 2015;400:32-40 pubmed publisher
    b>Osterix is an essential transcription factor for osteoblast differentiation and bone formation. The mechanism of regulation of Osterix by post-translational modification remains unknown...
  43. Omatsu Y, Nagasawa T. The critical and specific transcriptional regulator of the microenvironmental niche for hematopoietic stem and progenitor cells. Curr Opin Hematol. 2015;22:330-6 pubmed publisher
    ..b>Osterix as well as Ebf2 and Bmi1 are critical but not specific transcriptional regulators of HSPC niche development...
  44. Inman K, Rudin N, Cheng K, Robinson C, Kirschner A, Inman Semerau L, et al. Lab Retriever: a software tool for calculating likelihood ratios incorporating a probability of drop-out for forensic DNA profiles. BMC Bioinformatics. 2015;16:298 pubmed publisher
    ..Executable versions of the program are freely available for Mac OSX and Windows operating systems.
  45. Pinto Brod L, Fronza M, Vargas J, Lüdtke D, Luchese C, Wilhelm E, et al. Involvement of monoaminergic system in the antidepressant-like effect of (octylseleno)-xylofuranoside in the mouse tail suspension test. Prog Neuropsychopharmacol Biol Psychiatry. 2016;65:201-7 pubmed publisher
    ..the role of the monoaminergic system in the antidepressant-like action of (octylseleno)-xylofuranoside (OSX), an organoselenium compound, in the tail suspension test (TST) in mice. For this purpose, OSX (0...
  46. Kim H, Lee Y, Kim M, Kwon J, Song M, Lee Z, et al. Extracellular S100A4 negatively regulates osteoblast function by activating the NF-?B pathway. BMB Rep. 2017;50:97-102 pubmed
    ..The expression of osteoblast marker genes including osteocalcin and osterix was also suppressed...
  47. Xu W, Ong H, Zhu Y, Liu S, Liu L, Zhou K, et al. In Situ Release of VEGF Enhances Osteogenesis in 3D Porous Scaffolds Engineered with Osterix-Modified Adipose-Derived Stem Cells. Tissue Eng Part A. 2017;23:445-457 pubmed publisher
    ..Herein, rat ADSCs were isolated; transduced with lentiviruses expressing Osterix (Osx), a transcriptional factor essential for osteogenesis...
  48. Choi Y, Han Y, Jin S, Lee G, Kim G, Lee D, et al. Pseudoshikonin I enhances osteoblast differentiation by stimulating Runx2 and Osterix. J Cell Biochem. 2018;119:748-757 pubmed publisher
    ..transcriptional expression and osteogenic activity of osteoblast-specific transcription factors such as Runx2 and Osterix. To identify the signaling pathways that mediate PSI-induced osteoblastogenesis, we examined the effects of ..
  49. Tang Y, Liu L, Wang P, Chen D, Wu Z, Tang C. Periostin promotes migration and osteogenic differentiation of human periodontal ligament mesenchymal stem cells via the Jun amino-terminal kinases (JNK) pathway under inflammatory conditions. Cell Prolif. 2017;50: pubmed publisher
    ..impeded scratch closure, inhibited ALP activity and mineralization in vitro, and decreased expression of RUNX2, OSX, OPN and OCN in PDLSCs, while 75 ng/mL rhPOSTN significantly accelerated scratch closure, enhanced ALP activity ..
  50. Rashid H, Ma C, Chen H, Wang H, Hassan M, Sinha K, et al. Sp7 and Runx2 molecular complex synergistically regulate expression of target genes. Connect Tissue Res. 2014;55 Suppl 1:83-7 pubmed publisher
    ..Synergistic activation of FGF3 promoter was also noted in mesenchymal cells. Together, our data demonstrated that Runx2-Sp7 molecular complex functionally cooperate for maximal induction of cell-phenotype-restricted genes. ..
  51. Wang T, Wan D, Shao L, Dai J, Jiang C. Notoginsenoside R1 stimulates osteogenic function in primary osteoblasts via estrogen receptor signaling. Biochem Biophys Res Commun. 2015;466:232-9 pubmed publisher
    ..g., type I collagen (COL1), osteonectin, osteocalcin (OC), runt related protein 2 (Runx2), and osterix. NGR1 also promoted the mineralization process of osteoblasts...
  52. Amiri N, Christians J. PAPP-A2 expression by osteoblasts is required for normal postnatal growth in mice. Growth Horm IGF Res. 2015;25:274-80 pubmed publisher
    ..by crossing conditional Pappa2 deletion mice with mice expressing Cre recombinase under the control of the Sp7 (Osterix) promoter...
  53. Takarada T, Nakazato R, Tsuchikane A, Fujikawa K, Iezaki T, Yoneda Y, et al. Genetic analysis of Runx2 function during intramembranous ossification. Development. 2016;143:211-8 pubmed publisher
    ..b>Osterix (Osx) is another transcriptional determinant of osteoblast lineages expressed by osteoblast precursors; Osx is ..
  54. Sakisaka Y, Kanaya S, Nakamura T, Tamura M, Shimauchi H, Nemoto E. p38 MAP kinase is required for Wnt3a-mediated osterix expression independently of Wnt-LRP5/6-GSK3? signaling axis in dental follicle cells. Biochem Biophys Res Commun. 2016;478:527-32 pubmed publisher
    ..Recently, we have reported that Wnt3a increases alkaline phosphatase expression through the induction of osterix (Osx) expression in dental follicle cells, a precursor of cementoblasts...
  55. Kobayashi Y, Uehara S, Udagawa N, Takahashi N. Regulation of bone metabolism by Wnt signals. J Biochem. 2016;159:387-92 pubmed publisher
    ..The activation of Wnt/β-catenin signalling induces the expression of osterix, a transcription factor, which promotes osteoblast differentiation...
  56. Lee H, Chae H, Park S, Kim J. Porcine placenta hydrolysates enhance osteoblast differentiation through their antioxidant activity and effects on ER stress. BMC Complement Altern Med. 2016;16:291 pubmed publisher
    ..ALP, osteocalcin, Runx2, and osterix expression levels were evaluated by RT-PCR using isolated RNA...
  57. Yu T, Winkler C. Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model. J Vis Exp. 2017;: pubmed publisher
    ..transgenic medaka lines that express ctsk:nlGFP in osteoclasts, as well as mCherry under the control of the osterix (osx) promoter in premature osteoblasts, can be used to study the interaction of both cell types...
  58. Qian D, Yan G, Bai B, Chen Y, Zhang S, Yao Y, et al. Differential circRNA expression profiles during the BMP2-induced osteogenic differentiation of MC3T3-E1 cells. Biomed Pharmacother. 2017;90:492-499 pubmed publisher
    ..The present study identified circ19142 and circ5846 as being associated with osteoblast differentiation and BMP2 may induce osteogenic differentiation through a circ19142/circ5846-targeted miRNA-mRNA axis. ..
  59. Liu Y, Sharma T, Chen I, Reichenberger E, Ueki Y, Arif Y, et al. Rescue of a cherubism bone marrow stromal culture phenotype by reducing TGFβ signaling. Bone. 2018;111:28-35 pubmed publisher
    ..3 expression 24-fold and increased the expression of osteoblast gene markers Osterix (Sp7) 25-fold, Bone Sialoprotein (BSP) 7-fold, Osteocalcin (Bglap1) 100-fold, and Dentin Matrix Protein 1 (DMP1) ..
  60. Park N, Lim K, Han M, Che X, Park C, Kim J, et al. Core Binding Factor β Plays a Critical Role During Chondrocyte Differentiation. J Cell Physiol. 2016;231:162-71 pubmed publisher
    ..increased and the expression of chondrocyte maturation markers at the growth plates, including Runx2, osterix, and osteopontin, significantly diminished in Cbfb(Δch/Δch) mice compared to wild type mice...
  61. Filtz E, Emery A, Lu H, Forster C, Karasch C, Hallstrom T. Rb1 and Pten Co-Deletion in Osteoblast Precursor Cells Causes Rapid Lipoma Formation in Mice. PLoS ONE. 2015;10:e0136729 pubmed publisher
    ..To better understand the function of Pten in bone development in vivo, we conditionally deleted Pten in OSX(+) osteoprogenitor cells using OSX-Cre mice...
  62. Kim H, Kwon Y, Bae Y, Kim Y. Enhancement of human mesenchymal stem cell differentiation by combination treatment with 5-azacytidine and trichostatin A. Biotechnol Lett. 2016;38:167-74 pubmed publisher
    ..Quantitative analyses at the protein level showed 8.9-, 26.8-, 27.9-, and 28.5-fold upregulation of osterix, MAP-2, nestin, and type II collagen), respectively...
  63. Zheng D, Neoh K, Kang E. Immobilization of alendronate on titanium via its different functional groups and the subsequent effects on cell functions. J Colloid Interface Sci. 2017;487:1-11 pubmed publisher
    ..The expressions of runt-related transcription factor 2, osterix, osteopontin and osteocalcin in hMSCs cultured on this substrate were monitored...
  64. Chen L, Hu B, Shi X, Ren M, Yu W, Cen S, et al. Baicalein enhances the osteogenic differentiation of human periodontal ligament cells by activating the Wnt/β-catenin signaling pathway. Arch Oral Biol. 2017;78:100-108 pubmed publisher
    ..The expression of runt-related transcription factor 2 (RUNX2), bone morphogenetic protein 2 (BMP2), Osterix (OSX) and osteocalcin (OCN) were elevated after baicalein administration...
  65. Bae S, Min Y, Hwang E. Potent osteogenic activity of a novel imidazobenzimidazole derivative, IBIP. Biochem Biophys Res Commun. 2017;487:409-414 pubmed publisher
    ..promoted osteoblast differentiation and increased the expression of osteoblast-specific gene markers, such as osterix and alkaline phosphatase, in a dose-dependent manner...
  66. Tzeng Y, Chung N, Chen Y, Huang H, Chunang W, Lai D. Imbalanced osteogenesis and adipogenesis in mice deficient of the chemokine Cxcl12/Sdf1 in the bone mesenchymal stem/progenitor cells. J Bone Miner Res. 2017;: pubmed publisher
    ..Targeted deletion of Cxcl12 in Prx1- or Osx-expressing mesenchymal stem/progenitor cells (MSPCs), but not in mature osteoblasts, resulted in marrow adiposity ..
  67. Iyyanar P, Nazarali A. Hoxa2 Inhibits Bone Morphogenetic Protein Signaling during Osteogenic Differentiation of the Palatal Mesenchyme. Front Physiol. 2017;8:929 pubmed publisher
    ..Collectively, these data demonstrate for the first time that Hoxa2 may regulate palate development by inhibiting osteogenic differentiation of palatal mesenchyme via modulating BMP signaling. ..
  68. Choi H, Kim T, Yun C, Kim J, Cho E. Testicular acid phosphatase induces odontoblast differentiation and mineralization. Cell Tissue Res. 2016;364:95-103 pubmed publisher
    ..Expression of TNAP, Osx, Phex and Dsp is reduced by knockdown of ACPT but is enhanced by ACPT overexpression...
  69. Srikanth L, Sunitha M, Kumar P, Chandrasekhar C, Vengamma B, Sarma P. Gel based in vitro 3D model exploring the osteocytic potentiality of human CD34+ stem cells. Mol Biol Rep. 2016;43:1233-1242 pubmed
    ..qPCR expression analysis showed early and mature osteoblastic markers like RUNX2, Osterix, RANKL, along with osteocyte markers SPARC, Sclerostin...
  70. Wang P, Ma T, Guo D, Hu K, Shu Y, Xu H, et al. Metformin induces osteoblastic differentiation of human induced pluripotent stem cell-derived mesenchymal stem cells. J Tissue Eng Regen Med. 2018;12:437-446 pubmed publisher
    ..and increased expression of osteogenic markers, including Runt-related transcription factor 2 (RUNX2) and osterix. Inhibition of LKB1 activity, a common upstream AMPK kinase, markedly reversed metformin-induced AMPK activation, ..
  71. Wongwitwichot P, Kaewsrichan J. Osteogenic differentiation of mesenchymal stem cells is impaired by bone morphogenetic protein 7. Adv Med Sci. 2017;62:266-272 pubmed publisher
    ..The BM-MSCs greatly proliferated with active transcription of runx2 and osterix genes when induced by FGF2 and insulin...
  72. Amirhosseini M, Madsen R, Escott K, Bostrom M, Ross F, Fahlgren A. GSK-3β inhibition suppresses instability-induced osteolysis by a dual action on osteoblast and osteoclast differentiation. J Cell Physiol. 2018;233:2398-2408 pubmed publisher
    ..After 3 days of treatment with AR28, mRNA levels of β-catenin, Runx2, Osterix, Col1α1, and ALP were increased leading to higher osteoblast numbers compared to vehicle-treated animals...
  73. Wang Y, Shen M, Wang S, Wen X, Han X, Zhang Z, et al. Inhibition of the TGF-?1/Smad signaling pathway protects against cartilage injury and osteoarthritis in a rat model. Life Sci. 2017;189:106-113 pubmed publisher
    ..Immunohistochemical staining was used to determine the expression of the specific transcription factor Osterix as well as TGF-?1 related factors...
  74. Ramazzotti G, Bavelloni A, Blalock W, Piazzi M, Cocco L, Faenza I. BMP-2 Induced Expression of PLCβ1 That is a Positive Regulator of Osteoblast Differentiation. J Cell Physiol. 2016;231:623-9 pubmed publisher
    ..Since miR-214 is a regulator of Osterix (Osx) which is an osteoblast-specific transcription factor that is needful for osteoblast differentiation and ..
  75. Zhong Z, Niu P, Wang M, Huang G, Xu S, Sun Y, et al. Targeted disruption of sp7 and myostatin with CRISPR-Cas9 results in severe bone defects and more muscular cells in common carp. Sci Rep. 2016;6:22953 pubmed publisher
    ..These results demonstrate that both TALEN and CRISPR-Cas9 are highly efficient tools for modifying the common carp genome, and open avenues for facilitating common carp genetic studies and breeding. ..
  76. Yang Y, Huang Y, Zhang L, Zhang C. Transcriptional regulation of bone sialoprotein gene expression by Osx. Biochem Biophys Res Commun. 2016;476:574-579 pubmed publisher
    ..Osteoblasts produce a characteristic extracellular collagenous matrix that subsequently becomes mineralized. Osterix (Osx) is an osteoblast-specific transcription factor required for osteoblast differentiation...
  77. Kanaya K, Iba K, Dohke T, Okazaki S, Yamashita T. TRPV1, ASICs and P2X2/3 expressed in bone cells simultaneously regulate bone metabolic markers in ovariectomized mice. J Musculoskelet Neuronal Interact. 2016;16:145-51 pubmed
    ..The effects of nociceptor antagonists on the up-regulated expression of bone metabolic markers, Runx2, Osterix, osteocalcin and RANKL, were also examined...
  78. Shen W, Le S, Li Y, Hu F. SeqKit: A Cross-Platform and Ultrafast Toolkit for FASTA/Q File Manipulation. PLoS ONE. 2016;11:e0163962 pubmed publisher
    ..SeqKit provides executable binary files for all major operating systems, including Windows, Linux, and Mac OSX, and can be directly used without any dependencies or pre-configurations...
  79. Hyung J, Ahn C, Je J. Blue mussel (Mytilus edulis) protein hydrolysate promotes mouse mesenchymal stem cell differentiation into osteoblasts through up-regulation of bone morphogenetic protein. Food Chem. 2018;242:156-161 pubmed publisher
    ..signal and transcription factors, including p-Smad1/5/8, Dlx5, runt-related transcription factor 2 (Runx2), and osterix. BMPH<1kDa activated phosphorylation of mitogen-activated protein kinases...
  80. Duan X, Bradbury S, Olsen B, Berendsen A. VEGF stimulates intramembranous bone formation during craniofacial skeletal development. Matrix Biol. 2016;52-54:127-140 pubmed publisher
    ..In this study a conditional knockdown strategy was used to genetically delete Vegfa expression in Osterix (Osx) and collagen II (Col2)-expressing NCC descendants...
  81. Xue L, Jiang Y, Han T, Zhang N, Qin L, Xin H, et al. Comparative proteomic and metabolomic analysis reveal the antiosteoporotic molecular mechanism of icariin from Epimedium brevicornu maxim. J Ethnopharmacol. 2016;192:370-381 pubmed publisher
    ..Icariin also increased mRNA expression of Runx2 and osterix of OB, decreased CTR and CAII mRNA expression and protein expression of P38 and JNK...
  82. Scanlon V, Walia B, Yu J, Hansen M, Drissi H, Maye P, et al. Loss of Cbl-PI3K interaction modulates the periosteal response to fracture by enhancing osteogenic commitment and differentiation. Bone. 2017;95:124-135 pubmed publisher
    ..Here, we investigated the role of PI3K signaling during the very early stages of fracture healing using OsterixRFP reporter mice...
  83. Takano A, Fukuda T, Shinjo T, Iwashita M, Matsuzaki E, Yamamichi K, et al. Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation. Metabolism. 2017;69:157-170 pubmed publisher
    ..It also down-regulated the expression of Osterix, but not that of runt-related transcription factor 2 (Runx2), suggesting that Angptl2 is a positive activator of ..
  84. Zhang L, Tang Y, Zhu X, Tu T, Sui L, Han Q, et al. Overexpression of MiR-335-5p Promotes Bone Formation and Regeneration in Mice. J Bone Miner Res. 2017;32:2466-2475 pubmed publisher
    ..end, we generated a transgenic mouse line specifically overexpressing miR-335-5p in osteoblasts lineage by the osterix promoter and characterized its bone phenotype...
  85. Jin B, Choung P. Recombinant Human Plasminogen Activator Inhibitor-1 Accelerates Odontoblastic Differentiation of Human Stem Cells from Apical Papilla. Tissue Eng Part A. 2016;22:721-32 pubmed publisher
    ..We also observed that rhPAI-1 upregulated the expression of Smad4, nuclear factor I-C (NFI-C), Runx2, and osterix (OSX) during odontogenic differentiation...
  86. Yang G, Yuan G, Macdougall M, Zhi C, Chen S. BMP-2 induced Dspp transcription is mediated by Dlx3/Osx signaling pathway in odontoblasts. Sci Rep. 2017;7:10775 pubmed publisher
    ..However, the intimate mechanism is still unknown. Transcription factors Dlx3 and Osx are essential for odontoblasts differentiation...
  87. Chauveau C, Broux O, Delecourt C, Hardouin P, Jeanfils J, Devedjian J. Gene expression in normotopic and heterotopic human bone: increased level of SP7 mRNA in pathological tissue. Mol Cell Biochem. 2008;318:81-7 pubmed publisher
    ..b>OSTERIX/SP7 expression was observed for the first time in human adult bone biopsies...
  88. Chen Y, Wang M, Chen D, Wang J, Kang N. Chromatin remodeling enzyme CHD7 is necessary for osteogenesis of human mesenchymal stem cells. Biochem Biophys Res Commun. 2016;478:1588-93 pubmed publisher
    ..Overall, our study established a new epigenetic regulation of MSC osteogenic differentiation and provided a potential target for controlling MSC osteogenesis. ..
  89. Bendre A, Moritz N, Väänänen V, Maatta J. Dicer1 ablation in osterix positive bone forming cells affects cortical bone homeostasis. Bone. 2018;106:139-147 pubmed publisher
    ..Cre allele, enabling us, via tamoxifen administration, to time-controllably ablate Dicer1 gene expression in osterix expressing bone forming cells in post-natal mice...
  90. Paul S, Schindler S, Giovannone D, de Millo Terrazzani A, Mariani F, Crump J. Ihha induces hybrid cartilage-bone cells during zebrafish jawbone regeneration. Development. 2016;143:2066-76 pubmed publisher
  91. Pérez Campo F, Santurtún A, García Ibarbia C, Pascual M, Valero C, Garcés C, et al. Osterix and RUNX2 are Transcriptional Regulators of Sclerostin in Human Bone. Calcif Tissue Int. 2016;99:302-9 pubmed publisher
    ..Two bone-specific transcription factors, RUNX2 and OSX, have been shown to interact and co-ordinately regulate the expression of bone-specific genes...
  92. Artigas N, Gámez B, Cubillos Rojas M, Sánchez de Diego C, Valer J, Pons G, et al. p53 inhibits SP7/Osterix activity in the transcriptional program of osteoblast differentiation. Cell Death Differ. 2017;24:2022-2031 pubmed publisher
    Osteoblast differentiation is achieved by activating a transcriptional network in which Dlx5, Runx2 and Osx/SP7 have fundamental roles...