osteopontin

Summary

Gene Symbol: osteopontin
Description: secreted phosphoprotein 1
Alias: BNSP, BSPI, ETA-1, OPN, osteopontin, SPP1/CALPHA1 fusion, early T-lymphocyte activation 1, nephropontin, osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein, secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1), secreted phosphoprotein 1 variant 6, urinary stone protein, uropontin
Species: human
Products:     osteopontin

Top Publications

  1. Macri A, Versaci A, Lupo G, Trimarchi G, Tomasello C, Loddo S, et al. Role of osteopontin in breast cancer patients. Tumori. 2009;95:48-52 pubmed
    ..b>Osteopontin, a specific phosphoglycoprotein isolated from extracellular bone matrix and actively involved in mechanisms of ..
  2. Courter D, Cao H, Kwok S, Kong C, Banh A, Kuo P, et al. The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways. PLoS ONE. 2010;5:e9633 pubmed publisher
    Human osteopontin (OPN), a known tumor associated protein, exists in different isoforms, whose function is unclear. It also possesses a RGD domain, which has been implicated in diverse function...
  3. Ribeiro Silva A, Oliveira da Costa J. Osteopontin expression according to molecular profile of invasive breast cancer: a clinicopathological and immunohistochemical study. Int J Biol Markers. 2008;23:154-60 pubmed
    b>Osteopontin (OPN) is a secreted, calcium-binding phosphorylated glycoprotein involved in several physiological and pathological events such as angiogenesis, apoptosis, inflammation, wound healing, vascular remodeling, calcification of ..
  4. Fong Y, Liu S, Huang C, Li T, Hsu S, Kao S, et al. Osteopontin increases lung cancer cells migration via activation of the alphavbeta3 integrin/FAK/Akt and NF-kappaB-dependent pathway. Lung Cancer. 2009;64:263-70 pubmed publisher
    Tumor malignancy is associated with several features such as proliferation ability and frequency of metastasis. Osteopontin (OPN), which is abundantly expressed in bone matrix, is involved in cell adhesion, migration, invasion and cell ..
  5. Vogt M, ten Kate J, Drent R, Polman C, Hupperts R. Increased osteopontin plasma levels in multiple sclerosis patients correlate with bone-specific markers. Mult Scler. 2010;16:443-9 pubmed publisher
    The pro-inflammatory cytokine osteopontin has been found to be highly expressed in multiple sclerosis lesions and plasma levels are increased during relapses in relapse-onset multiple sclerosis patients...
  6. Bazzichi L, Ghiadoni L, Rossi A, Bernardini M, Lanza M, De Feo F, et al. Osteopontin is associated with increased arterial stiffness in rheumatoid arthritis. Mol Med. 2009;15:402-6 pubmed publisher
    ..It has been suggested that osteopontin (OPN), a cytokine involved in RA pathogenesis, might have vascular effects...
  7. Tilli T, Franco V, Robbs B, Wanderley J, da Silva F, de Mello K, et al. Osteopontin-c splicing isoform contributes to ovarian cancer progression. Mol Cancer Res. 2011;9:280-93 pubmed publisher
    ..b>Osteopontin (OPN) is one of the proteins overexpressed in ovarian cancer and is involved in tumorigenesis and metastasis...
  8. Christensen B, Kläning E, Nielsen M, Andersen M, Sørensen E. C-terminal modification of osteopontin inhibits interaction with the ?V?3-integrin. J Biol Chem. 2012;287:3788-97 pubmed publisher
    b>Osteopontin (OPN) is a multifunctional phosphorylated protein containing the integrin binding sequence Arg-Gly-Asp through which it interacts with several integrin receptors, such as the ?(V)?(3)-integrin...
  9. Morales Ibanez O, Dominguez M, Ki S, Marcos M, Chaves J, Nguyen Khac E, et al. Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis. Hepatology. 2013;58:1742-56 pubmed publisher
    We identified, in the transcriptome analysis of patients with alcoholic hepatitis (AH), osteopontin (OPN) as one of the most up-regulated genes. Here, we used a translational approach to investigate its pathogenic role...

More Information

Publications72

  1. Tilli T, Thuler L, Matos A, Coutinho Camillo C, Soares F, Da Silva E, et al. Expression analysis of osteopontin mRNA splice variants in prostate cancer and benign prostatic hyperplasia. Exp Mol Pathol. 2012;92:13-9 pubmed publisher
    b>Osteopontin splicing isoforms (OPN-SI) present differential expression patterns and specific tumor roles...
  2. Trivedi T, Franek B, Green S, Kariuki S, Kumabe M, Mikolaitis R, et al. Osteopontin alleles are associated with clinical characteristics in systemic lupus erythematosus. J Biomed Biotechnol. 2011;2011:802581 pubmed publisher
    Variants of the osteopontin (OPN) gene have been associated with systemic lupus erythematosus (SLE) susceptibility and cytokine profiles in SLE patients...
  3. Pietras A, Katz A, Ekström E, Wee B, Halliday J, Pitter K, et al. Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth. Cell Stem Cell. 2014;14:357-69 pubmed publisher
    ..The CD44 ligand osteopontin shared a perivascular expression pattern with CD44 and promoted glioma stem cell-like phenotypes...
  4. Xue Y, Zhang X, Dong Q, Sun J, Dai C, Zhou H, et al. Thrombin is a therapeutic target for metastatic osteopontin-positive hepatocellular carcinoma. Hepatology. 2010;52:2012-22 pubmed publisher
    We previously identified osteopontin (OPN) as a promoter and thus a potential therapeutic target for hepatocellular carcinoma (HCC) metastasis. The serine protease thrombin interacts with OPN and can modify its biological activity...
  5. Barizzone N, Marchini M, Cappiello F, Chiocchetti A, Orilieri E, Ferrante D, et al. Association of osteopontin regulatory polymorphisms with systemic sclerosis. Hum Immunol. 2011;72:930-4 pubmed publisher
    To test the involvement of osteopontin gene (OPN) in systemic sclerosis (SSc) susceptibility, two OPN single nucleotide polymorphisms previously reported to be associated with systemic lupus erythematosus, namely -156G/GG (proximal ..
  6. Lin F, Li Y, Cao J, Fan S, Wen J, Zhu G, et al. Overexpression of osteopontin in hepatocellular carcinoma and its relationships with metastasis, invasion of tumor cells. Mol Biol Rep. 2011;38:5205-10 pubmed publisher
    b>Osteopontin (OPN) plays an important role in metastasis and relapse of human cancer. However, the whole story of OPN relating to cancer has been far from clear untill now...
  7. Chen Y, Liu H, Wu W, Li Y, Li J. Osteopontin genetic variants are associated with overall survival in advanced non-small-cell lung cancer patients and bone metastasis. J Exp Clin Cancer Res. 2013;32:45 pubmed publisher
    b>Osteopontin (OPN) plays important roles in the modulation of apoptosis, angiogenesis, immune response, and tumor invasion...
  8. Hsu K, Tsai H, Lin P, Hsu Y, Shan Y, Lu P. Osteopontin expression is an independent adverse prognostic factor in resectable gastrointestinal stromal tumor and its interaction with CD44 promotes tumor proliferation. Ann Surg Oncol. 2010;17:3043-52 pubmed publisher
    b>Osteopontin (OPN) is a multifunctional secreted glycophosphoprotein involved in miscellaneous physiologic and pathologic processes and is functionally related to the transmembrane receptor CD44...
  9. Yan W, Qian C, Zhao P, Zhang J, Shi L, Qian J, et al. Expression pattern of osteopontin splice variants and its functions on cell apoptosis and invasion in glioma cells. Neuro Oncol. 2010;12:765-75 pubmed publisher
    b>Osteopontin (OPN) is widely overexpressed in various cancers, including gliomas, and plays an important role in tumorigenesis. However, the expression pattern and functions of OPN splice variants expressed in gliomas remain unclear...
  10. Zhao X, Dong J, Zhang W, Liu Z. Prognosis of ampullary cancer based on immunohistochemical type and expression of osteopontin. Diagn Pathol. 2011;6:98 pubmed publisher
    ..The relationship of AC subtype and expression of Osteopontin (OPN) with the prognosis of 120 AC patients after pancreaticoduodenectomy was investigated...
  11. Briese J, Cheng S, Ezzat S, Liu W, Winer D, Wagener C, et al. Osteopontin (OPN) expression in thyroid carcinoma. Anticancer Res. 2010;30:1681-8 pubmed
    b>Osteopontin (OPN) and its interacting partner CEA-cell adhesion molecule (CEACAM1) mediate similar biological functions and have been expressed in several types of cancer...
  12. Sullivan J, Blair L, Alnajar A, Aziz T, Chipitsyna G, Gong Q, et al. Expression and regulation of nicotine receptor and osteopontin isoforms in human pancreatic ductal adenocarcinoma. Histol Histopathol. 2011;26:893-904 pubmed publisher
    b>Osteopontin (OPN) is a secreted phospho-protein that confers on cancer cells a migratory phenotype...
  13. Chang W, Yang H, Cheng H, Chuang C, Lu P, Sheu B. Increased gastric osteopontin expression by Helicobacter pylori Infection can correlate with more severe gastric inflammation and intestinal metaplasia. Helicobacter. 2011;16:217-24 pubmed publisher
    b>Osteopontin (OPN) is involved in the gastric cancer progression...
  14. Zheng Y, Tian C, Meng Y, Qin Y, Du Y, Du J, et al. Osteopontin stimulates autophagy via integrin/CD44 and p38 MAPK signaling pathways in vascular smooth muscle cells. J Cell Physiol. 2012;227:127-35 pubmed publisher
    b>Osteopontin (OPN) exerts pro-inflammatory effect and is associated with the development of abdominal aortic aneurysm (AAA). However, the molecular mechanism underlying this association remains obscure...
  15. Jin Y, Tong D, Chen J, Feng Z, Yang J, Shao C, et al. Overexpression of osteopontin, ?v?3 and Pim-1 associated with prognostically important clinicopathologic variables in non-small cell lung cancer. PLoS ONE. 2012;7:e48575 pubmed publisher
    In this study, we examined the expression of osteopontin (OPN), ?v?3 and Pim-1 in non-small cell lung cancer (NSCLC) and investigated the potential clinical implications of their expression patterns in NSCLC...
  16. Wang Y, Yan W, Lu X, Qian C, Zhang J, Li P, et al. Overexpression of osteopontin induces angiogenesis of endothelial progenitor cells via the av?3/PI3K/AKT/eNOS/NO signaling pathway in glioma cells. Eur J Cell Biol. 2011;90:642-8 pubmed publisher
    ..Recent studies have shown that osteopontin (OPN) is a secreted, integrin-binding protein that contributes to glioma progression...
  17. Sun J, Feng A, Chen S, Zhang Y, Xie Q, Yang M, et al. Osteopontin splice variants expressed by breast tumors regulate monocyte activation via MCP-1 and TGF-?1. Cell Mol Immunol. 2013;10:176-82 pubmed publisher
    b>Osteopontin (OPN), a multifunctional glycoprotein, has three transcripts that have distinct roles in tumors in vitro. Whether OPN transcripts have different functions in tumor processes in vivo is unclear...
  18. Shi Z, Mirza M, Wang B, Kennedy M, Weber G. Osteopontin-a alters glucose homeostasis in anchorage-independent breast cancer cells. Cancer Lett. 2014;344:47-53 pubmed publisher
    Invasive breast tumor cells generate three splice variants of the metastasis gene osteopontin, while non-invasive breast cells express only the unspliced form or no osteopontin at all...
  19. Yang M, Ramachandran A, Yan H, Woolbright B, Copple B, Fickert P, et al. Osteopontin is an initial mediator of inflammation and liver injury during obstructive cholestasis after bile duct ligation in mice. Toxicol Lett. 2014;224:186-95 pubmed publisher
    b>Osteopontin (OPN) is a chemotactic factor which can be cleaved to the pro-inflammatory form by matrix metalloproteinases (MMPs)...
  20. Li N, Weber C, Mi Z, Wai P, Cuevas B, Kuo P. Osteopontin up-regulates critical epithelial-mesenchymal transition transcription factors to induce an aggressive breast cancer phenotype. J Am Coll Surg. 2013;217:17-26; discussion 26 pubmed publisher
    ..We have previously shown in a xenograft breast cancer model that blocking osteopontin (OPN), a secreted phosphoprotein, decreases EMT...
  21. Phillips R, Helbig K, Van der Hoek K, Seth D, Beard M. Osteopontin increases hepatocellular carcinoma cell growth in a CD44 dependant manner. World J Gastroenterol. 2012;18:3389-99 pubmed publisher
    To investigate the role of osteopontin (OPN) and its splice variants in the proliferation of hepatocellular carcinoma (HCC)...
  22. Tousoulis D, Siasos G, Maniatis K, Oikonomou E, Kioufis S, Zaromitidou M, et al. Serum osteoprotegerin and osteopontin levels are associated with arterial stiffness and the presence and severity of coronary artery disease. Int J Cardiol. 2013;167:1924-8 pubmed publisher
    b>Osteopontin (OPN) and osteoprotegerin (OPG) have recently emerged as key factors in both vascular remodeling and development of atherosclerosis. Arterial stiffness has an independent predictive value for cardiovascular events...
  23. Nishimichi N, Hayashita Kinoh H, Chen C, Matsuda H, Sheppard D, Yokosaki Y. Osteopontin undergoes polymerization in vivo and gains chemotactic activity for neutrophils mediated by integrin alpha9beta1. J Biol Chem. 2011;286:11170-8 pubmed publisher
    b>Osteopontin (OPN) is an integrin-binding inflammatory cytokine that undergoes polymerization catalyzed by transglutaminase 2...
  24. Patouraux S, Bonnafous S, Voican C, Anty R, Saint Paul M, Rosenthal Allieri M, et al. The osteopontin level in liver, adipose tissue and serum is correlated with fibrosis in patients with alcoholic liver disease. PLoS ONE. 2012;7:e35612 pubmed publisher
    b>Osteopontin (OPN) plays an important role in the progression of chronic liver diseases...
  25. Zhang H, Guo M, Chen J, Wang Z, Du X, Liu P, et al. Osteopontin knockdown inhibits ?v,?3 integrin-induced cell migration and invasion and promotes apoptosis of breast cancer cells by inducing autophagy and inactivating the PI3K/Akt/mTOR pathway. Cell Physiol Biochem. 2014;33:991-1002 pubmed publisher
    b>Osteopontin (OPN) is associated with tumor formation, progression and metastasis, and increased OPN levels have been associated with poor survival in breast cancer...
  26. El Din Bessa S, Elwan N, Suliman G, El Shourbagy S. Clinical significance of plasma osteopontin level in Egyptian patients with hepatitis C virus-related hepatocellular carcinoma. Arch Med Res. 2010;41:541-7 pubmed publisher
    Hepatocellular carcinoma (HCC) is one of the most common and aggressive malignancies worldwide. Osteopontin (OPN) is a secreted glycoprotein frequently associated with various tumors...
  27. Takenaka M, Hanagiri T, Shinohara S, Yasuda M, Chikaishi Y, Oka S, et al. Serum level of osteopontin as a prognostic factor in patients who underwent surgical resection for non-small-cell lung cancer. Clin Lung Cancer. 2013;14:288-94 pubmed publisher
    b>OPN is a multifunctional glycophosphoprotein originally described as a secreted protein from malignant epithelial cells...
  28. Lu D, Yeh W, Huang S, Tang C, Lin H, Chou S. Osteopontin increases heme oxygenase-1 expression and subsequently induces cell migration and invasion in glioma cells. Neuro Oncol. 2012;14:1367-78 pubmed publisher
    ..b>Osteopontin is abundantly expressed in the brain and is involved in cell adhesion, migration, and invasion...
  29. Uede T. Osteopontin, intrinsic tissue regulator of intractable inflammatory diseases. Pathol Int. 2011;61:265-80 pubmed publisher
    ..Matricellular proteins including osteopontin (OPN) and tenascin-c (TN-C) are highly expressed at the pathological foci of various inflammatory diseases...
  30. Piva L, Gavassini B, Bello L, Fanin M, Sorarù G, Barp A, et al. TGFBR2 but not SPP1 genotype modulates osteopontin expression in Duchenne muscular dystrophy muscle. J Pathol. 2012;228:251-9 pubmed publisher
    A polymorphism (rs28357094) in the promoter region of the SPP1 gene coding for osteopontin (OPN) is a strong determinant of disease severity in Duchenne muscular dystrophy (DMD)...
  31. Chen G, Zhang X, Li R, Fang L, Niu X, Zheng Y, et al. Role of osteopontin in synovial Th17 differentiation in rheumatoid arthritis. Arthritis Rheum. 2010;62:2900-8 pubmed publisher
    b>Osteopontin (OPN) that is aberrantly produced in rheumatoid synovium is thought to play an important role in rheumatoid arthritis (RA)...
  32. Chuang C, Chang H, Lin P, Sun S, Chen P, Lin Y, et al. Up-regulation of osteopontin expression by aryl hydrocarbon receptor via both ligand-dependent and ligand-independent pathways in lung cancer. Gene. 2012;492:262-9 pubmed publisher
    The secreted glycol-phosphoprotein OPN not only plays important roles in immune responses and tissue remodeling but is also intimately involved in tumorigenesis. It is up-regulated in various cancers and correlated with poor prognosis...
  33. Hahnel A, Wichmann H, Kappler M, Kotzsch M, Vordermark D, Taubert H, et al. Effects of osteopontin inhibition on radiosensitivity of MDA-MB-231 breast cancer cells. Radiat Oncol. 2010;5:82 pubmed publisher
    b>Osteopontin (OPN) is a secreted glycophosphoprotein that is overexpressed in various tumors, and high levels of OPN have been associated with poor prognosis of cancer patients...
  34. Weber G, Lett G, Haubein N. Categorical meta-analysis of Osteopontin as a clinical cancer marker. Oncol Rep. 2011;25:433-41 pubmed publisher
    ..In particular, the cancer metastasis gene Osteopontin has been investigated extensively but it has not yet been applied to routine diagnostics...
  35. Erpolat O, Gocun P, Akmansu M, Ozgun G, Akyol G. Hypoxia-related molecules HIF-1?, CA9, and osteopontin : predictors of survival in patients with high-grade glioma. Strahlenther Onkol. 2013;189:147-54 pubmed publisher
    A high expression of hypoxia-inducible factor-1 alpha (HIF)-1?, carbonic anhydrase 9 (CA9), and osteopontin appears to be a strong prognostic indicator in many malignancies; however, their role is unclear in high-grade gliomas...
  36. Boudjadi S, Bernatchez G, Beaulieu J, Carrier J. Control of the human osteopontin promoter by ERR? in colorectal cancer. Am J Pathol. 2013;183:266-76 pubmed publisher
    Colorectal cancer is the second leading cause of death from cancer. Osteopontin (OPN) is a component of tumor extracellular matrix identified as a key marker of cancer progression...
  37. Yamaguchi Y, Shao Z, Sharif S, Du X, Myles T, Merchant M, et al. Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage. J Biol Chem. 2013;288:3097-111 pubmed publisher
    b>Osteopontin (OPN), which is highly expressed in malignant glioblastoma (GBM), possesses inflammatory activity modulated by proteolytic cleavage by thrombin and plasma carboxypeptidase B2 (CPB2) at a highly conserved cleavage site...
  38. Huan J, Xing L, Qin X, Gao Z, Pan X, Zhao Z. Expression and clinical significance of osteopontin in calcified breast tissue. Asian Pac J Cancer Prev. 2012;13:5219-23 pubmed
    b>Osteopontin (OPN) is an integrin-binding protein, believed to be involved in a variety of physiological cellular functions...
  39. Shimizu Y, Ota K, Ikeguchi R, Kubo S, Kabasawa C, Uchiyama S. Plasma osteopontin levels are associated with disease activity in the patients with multiple sclerosis and neuromyelitis optica. J Neuroimmunol. 2013;263:148-51 pubmed publisher
    b>Osteopontin (OPN) up-regulates pro-inflammatory cytokines from both T helper type 1 and T helper type 17 cell pathways...
  40. Xu L, Ma X, Wang Y, Li X, Qi Y, Cui B, et al. The expression and pathophysiological role of osteopontin in Graves' disease. J Clin Endocrinol Metab. 2011;96:E1866-70 pubmed publisher
    ..Its pathogenesis is tightly involved with aberrant proinflammatory cytokine production. Osteopontin (OPN), an extracellular matrix protein of pleiotropic properties, has recently been recognized as a potent ..
  41. Zhao F, Chen X, Meng T, Hao B, Zhang Z, Zhang G. Genetic polymorphisms in the osteopontin promoter increases the risk of distance metastasis and death in Chinese patients with gastric cancer. BMC Cancer. 2012;12:477 pubmed publisher
    In vitro and in vivo studies have suggested that osteopontin (OPN) is associated with many types of cancers. However, no studies have reported the incidence of OPN polymorphisms and the risk of gastric cancer...
  42. Chen R, Xia Y, Xue T, Ye S. Transcription factor c-Myb promotes the invasion of hepatocellular carcinoma cells via increasing osteopontin expression. J Exp Clin Cancer Res. 2010;29:172 pubmed publisher
    Specific gene expression is tightly regulated by various transcription factors. Osteopontin (OPN) is a phosphoprotein that mediates hepatocellular carcinoma (HCC) progression and metastasis...
  43. Abu El Asrar A, Imtiaz Nawaz M, Kangave D, Siddiquei M, Geboes K. Osteopontin and other regulators of angiogenesis and fibrogenesis in the vitreous from patients with proliferative vitreoretinal disorders. Mediators Inflamm. 2012;2012:493043 pubmed publisher
    The aim of this study was to determine the levels of the angiogenic and fibrogenic factors osteopontin (OPN), high-mobility group box-1 (HMGB1), and connective tissue growth factor (CTGF) and the antiangiogenic and antifibrogenic pigment ..
  44. Chu M, Yang P, Hu R, Hou S, Li F, Chen Y, et al. Elevated serum osteopontin levels and genetic polymorphisms of osteopontin are associated with Vogt-Koyanagi-Harada disease. Invest Ophthalmol Vis Sci. 2011;52:7084-9 pubmed publisher
    b>Osteopontin (OPN) is a proinflammatory cytokine involved in chronic inflammatory diseases. This study aimed to analyze the role of OPN in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease...
  45. Zeyda M, Gollinger K, Todoric J, Kiefer F, Keck M, Aszmann O, et al. Osteopontin is an activator of human adipose tissue macrophages and directly affects adipocyte function. Endocrinology. 2011;152:2219-27 pubmed publisher
    b>Osteopontin (OPN) is highly up-regulated in adipose tissue in human and murine obesity and has been recently shown to be functionally involved in the pathogenesis of obesity-induced adipose tissue inflammation and associated insulin ..
  46. Kariya Y, Kanno M, Matsumoto Morita K, Konno M, Yamaguchi Y, Hashimoto Y. Osteopontin O-glycosylation contributes to its phosphorylation and cell-adhesion properties. Biochem J. 2014;463:93-102 pubmed publisher
    OPN (osteopontin) is a multiphosphorylated extracellular glycoprotein, which has important roles in bone remodelling, inflammation and cancer metastasis...
  47. Anborgh P, Mutrie J, Tuck A, Chambers A. Role of the metastasis-promoting protein osteopontin in the tumour microenvironment. J Cell Mol Med. 2010;14:2037-44 pubmed publisher
    b>Osteopontin (OPN) is a secreted protein present in bodily fluids and tissues...
  48. Chen R, Xia Y, Xue T, Zhang H, Ye S. Down-regulation of osteopontin inhibits metastasis of hepatocellular carcinoma cells via a mechanism involving MMP-2 and uPA. Oncol Rep. 2011;25:803-8 pubmed publisher
    b>Osteopontin (OPN) has an important role in hepatocellular carcinoma (HCC) progression and metastasis. This study was to investigate the therapeutic potential of inhibition of OPN expression...
  49. Brown A, Islam T, Adams R, Nerle S, Kamara M, Eger C, et al. Osteopontin enhances HIV replication and is increased in the brain and cerebrospinal fluid of HIV-infected individuals. J Neurovirol. 2011;17:382-92 pubmed publisher
    ..In this regard, we identified through a subtractive hybridization strategy osteopontin (OPN, SPP1, gene) an inflammatory marker, as an upregulated gene in HIV-infected primary human monocyte-derived ..
  50. Nakayama H, Nagai H, Matsumoto K, Oguro R, Sugimoto K, Kamide K, et al. Association between osteopontin promoter variants and diastolic dysfunction in hypertensive heart in the Japanese population. Hypertens Res. 2011;34:1141-6 pubmed publisher
    ..b>Osteopontin (OPN) is a secreted phosphoprotein, which mediates fibrosis...
  51. Zhang R, Pan X, Huang Z, Weber G, Zhang G. Osteopontin enhances the expression and activity of MMP-2 via the SDF-1/CXCR4 axis in hepatocellular carcinoma cell lines. PLoS ONE. 2011;6:e23831 pubmed publisher
    b>Osteopontin, SDF-1?, and MMP-2 are important secreted molecules involved in the pathophysiology of human hepatocellular carcinoma (HCC)...
  52. Hillas G, Loukides S, Kostikas K, Simoes D, Petta V, Konstantellou E, et al. Increased levels of osteopontin in sputum supernatant of smoking asthmatics. Cytokine. 2013;61:251-5 pubmed publisher
    Smoking may modify the inflammatory pattern of the asthmatic airways. Osteopontin (OPN) has been associated with inflammation and fibrosis...
  53. Wasilewska A, Taranta Janusz K, Kuroczycka Saniutycz E, Zoch Zwierz W. Urinary OPN excretion in children with glomerular proteinuria. Adv Med Sci. 2011;56:193-9 pubmed publisher
    The aim of the study was to investigate urinary levels and clinical significance of osteopontin (uOPN) in children with different glomerular diseases according to histological diagnosis and degree of proteinuria...
  54. Luo X, Ruhland M, Pazolli E, Lind A, Stewart S. Osteopontin stimulates preneoplastic cellular proliferation through activation of the MAPK pathway. Mol Cancer Res. 2011;9:1018-29 pubmed publisher
    ..Previously we showed that senescence-associated stromal-derived osteopontin contributes to preneoplastic cell growth in vitro and in xenografts, suggesting that it impacts neoplastic ..
  55. El Asrar A, Missotten L, Geboes K. Expression of high-mobility groups box-1/receptor for advanced glycation end products/osteopontin/early growth response-1 pathway in proliferative vitreoretinal epiretinal membranes. Mol Vis. 2011;17:508-18 pubmed
    The high-mobility group box -1 (HMGB1)/receptor for advanced glycation end products (RAGE)/osteopontin (OPN)/early growth response-1 (Egr-1) pathway is involved in inflammation, angiogenesis, and fibrosis...
  56. Zhao B, Sun T, Meng F, Qu A, Li C, Shen H, et al. Osteopontin as a potential biomarker of proliferation and invasiveness for lung cancer. J Cancer Res Clin Oncol. 2011;137:1061-70 pubmed publisher
    Lung cancer is one of the most malignant tumors and poses a significant threat to human health. Osteopontin (OPN) is a variably expressed, secreted glycophosphoprotein that mediates the growth and metastases of several carcinoma types...
  57. Pegoraro E, Hoffman E, Piva L, Gavassini B, Cagnin S, Ermani M, et al. SPP1 genotype is a determinant of disease severity in Duchenne muscular dystrophy. Neurology. 2011;76:219-26 pubmed publisher
    ..and response to glucocorticoids were observed with polymorphism rs28357094 in the gene promoter of SPP1 (osteopontin)...
  58. Weber G, Lett G, Haubein N. Osteopontin is a marker for cancer aggressiveness and patient survival. Br J Cancer. 2010;103:861-9 pubmed publisher
    ..Meta-analysis is a valuable tool for biomarker validation. Here, we evaluate Osteopontin as a marker for tumor aggressiveness (grade, stage, early progression) and patient survival...
  59. Zhu W, Guo L, Zhang B, Lou L, Lin Z, Zhu X, et al. Combination of osteopontin with peritumoral infiltrating macrophages is associated with poor prognosis of early-stage hepatocellular carcinoma after curative resection. Ann Surg Oncol. 2014;21:1304-13 pubmed publisher
    ..This study was performed to elucidate the prognostic significance of combining tumor-secreted osteopontin (OPN) with microenvironment-associated peritumoral macrophages (PTMs) in hepatocellular carcinoma (HCC), ..
  60. Dong Q, Zhang X, Zhao Y, Jia H, Zhou H, Dai C, et al. Osteopontin promoter polymorphisms at locus -443 significantly affect the metastasis and prognosis of human hepatocellular carcinoma. Hepatology. 2013;57:1024-34 pubmed publisher
    b>Osteopontin (OPN) plays a crucial role in hepatocellular carcinoma (HCC) metastasis. However, little is known about the impact of OPN polymorphisms on cancer progression...
  61. Hoffman E, Gordish Dressman H, McLane V, Devaney J, Thompson P, Visich P, et al. Alterations in osteopontin modify muscle size in females in both humans and mice. Med Sci Sports Exerc. 2013;45:1060-8 pubmed publisher
    An osteopontin (OPN; SPP1) gene promoter polymorphism modifies disease severity in Duchenne muscular dystrophy, and we hypothesized that it might also modify muscle phenotypes in healthy volunteers...
  62. Shang S, Plymoth A, Ge S, Feng Z, Rosen H, Sangrajrang S, et al. Identification of osteopontin as a novel marker for early hepatocellular carcinoma. Hepatology. 2012;55:483-90 pubmed publisher
    ..Mass spectrometry profiling of highly fractionated plasma from 18 cirrhosis and 17 HCC patients identified osteopontin (OPN) as significantly up-regulated in HCC cases, compared to cirrhosis controls...
  63. Goparaju C, Pass H, Blasberg J, Hirsch N, Donington J. Functional heterogeneity of osteopontin isoforms in non-small cell lung cancer. J Thorac Oncol. 2010;5:1516-23 pubmed publisher
    b>Osteopontin (OPN) is a multifunctional protein with an important but poorly understood role in non-small cell lung cancer (NSCLC) pathogenesis...