OSMR

Summary

Gene Symbol: OSMR
Description: oncostatin M receptor
Alias: IL-31R-beta, IL-31RB, OSMRB, PLCA1, oncostatin-M-specific receptor subunit beta, IL-31 receptor subunit beta, IL-31R subunit beta, interleukin-31 receptor subunit beta, oncostatin-M specific receptor beta subunit
Species: human
Products:     OSMR

Top Publications

  1. Mosley B, De Imus C, Friend D, Boiani N, Thoma B, Park L, et al. Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. J Biol Chem. 1996;271:32635-43 pubmed
  2. Dillon S, Sprecher C, Hammond A, Bilsborough J, Rosenfeld Franklin M, Presnell S, et al. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat Immunol. 2004;5:752-60 pubmed
    ..These data indicate that IL-31 may be involved in promoting the dermatitis and epithelial responses that characterize allergic and non-allergic diseases. ..
  3. Arita K, South A, Hans Filho G, Sakuma T, Lai Cheong J, Clements S, et al. Oncostatin M receptor-beta mutations underlie familial primary localized cutaneous amyloidosis. Am J Hum Genet. 2008;82:73-80 pubmed publisher
    ..FPLCA has been mapped to 5p13.1-q11.2, and by candidate gene analysis, we identified missense mutations in the OSMR gene, encoding oncostatin M-specific receptor beta (OSMRbeta), in three families...
  4. Deng G, Kakar S, Okudiara K, Choi E, Sleisenger M, Kim Y. Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs. Clin Cancer Res. 2009;15:1519-26 pubmed publisher
    ..In melanoma cells, epigenetic silencing of OSM receptor (OSMR) by histone deacetylation contributes to escape of cell growth control by OSM...
  5. Wang W, Li L, Huang E, Zhang Q, Sun T, Song Q, et al. A new c.1845A?T of oncostatin M receptor-? mutation and slightly enhanced oncostatin M receptor-? expression in a Chinese family with primary localized cutaneous amyloidosis. Eur J Dermatol. 2012;22:29-33 pubmed publisher
    ..PLCA is more common in Southeast Asia and South America, where up to 10% of cases may be familial. Mutations of OSMR or IL31RA have been identified in PLCA...
  6. Winder D, Chattopadhyay A, Muralidhar B, Bauer J, English W, Zhang X, et al. Overexpression of the oncostatin M receptor in cervical squamous cell carcinoma cells is associated with a pro-angiogenic phenotype and increased cell motility and invasiveness. J Pathol. 2011;225:448-62 pubmed publisher
    Oncostatin M receptor (OSMR) shows frequent copy number gain and overexpression in advanced cervical squamous cell carcinoma (SCC)...
  7. Lin M, Lee D, Liu T, Lin Y, Chen S, Huang C, et al. Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis. Eur J Hum Genet. 2010;18:26-32 pubmed publisher
    ..Autosomal dominant PCA has been mapped earlier to 5p13.1-q11.2 and two pathogenic missense mutations in the OSMR gene, which encodes the interleukin-6 family cytokine receptor oncostatin M receptor beta (OSMRbeta), were reported...
  8. Tanaka A, Lai Cheong J, van den Akker P, Nagy N, Millington G, Diercks G, et al. The molecular skin pathology of familial primary localized cutaneous amyloidosis. Exp Dermatol. 2010;19:416-23 pubmed publisher
    ..The genetic basis of FPLCA involves mutations in the OSMR and IL31RA genes but the disease pathophysiology is not fully understood...
  9. Liu J, Hadjokas N, Mosley B, Estrov Z, Spence M, Vestal R. Oncostatin M-specific receptor expression and function in regulating cell proliferation of normal and malignant mammary epithelial cells. Cytokine. 1998;10:295-302 pubmed
    ..Together, these data suggest that OSM plays an inhibitory role in normal and malignant mammary epithelial cell growth in vitro. OSM activity is mediated by the OSM-specific receptor (type II), not by the OSM/LIF shared receptor. ..

More Information

Publications83

  1. Tiezzi F, Parker Gaddis K, Cole J, Clay J, Maltecca C. A genome-wide association study for clinical mastitis in first parity US Holstein cows using single-step approach and genomic matrix re-weighting procedure. PLoS ONE. 2015;10:e0114919 pubmed publisher
    ..phagocytosis of bacterial cells (C6, C7, C9, C1QTNF3), tumor suppression (DAB2), involution of mammary epithelium (OSMR) and cytokine regulation (PRLR). DAVID enrichment analysis revealed 5 KEGG pathways...
  2. Mahony C, Pasche C, Bertrand J. Oncostatin M and Kit-Ligand Control Hematopoietic Stem Cell Fate during Zebrafish Embryogenesis. Stem Cell Reports. 2018;: pubmed publisher
    ..Moreover, we identified the zebrafish ortholog of Oncostatin M (osm) in the zebrafish genome. We show that the osm/osmr pathway acts upstream of kitb during specification of the hemogenic endothelium, while both pathways act ..
  3. Xu P, Yang J, Liu J, Yang X, Liao J, Yuan F, et al. Identification of glioblastoma gene prognosis modules based on weighted gene co-expression network analysis. BMC Med Genomics. 2018;11:96 pubmed publisher
    ..Then, 228 hub genes were calculated based on gene significance (GS) and module significance (MS). Four genes (OSMR + SOX21 + MED10 + PTPRN) were selected to construct a Cox proportional hazards regression model with high ..
  4. Stephens J, Bailey J, Hang H, Rittell V, Dietrich M, Mynatt R, et al. Adipose Tissue Dysfunction Occurs Independently of Obesity in Adipocyte-Specific Oncostatin Receptor Knockout Mice. Obesity (Silver Spring). 2018;26:1439-1447 pubmed publisher
    This study examined the phenotypic effects of adipocyte-specific oncostatin M receptor (OSMR) loss in chow-fed mice. Chow-fed adipocyte-specific OSMR knockout (FKO) mice and littermate OSMRfl/fl controls were studied...
  5. Xiao J, Liong E, Huang H, On Tse W, Lau K, Pan J, et al. Cyclooxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury. Toxicol Sci. 2015;143:430-40 pubmed publisher
    ..In addition, level of hepato-protective molecules (eg, OSM and OSMR) and associated liver regeneration pathway were significantly inhibited by the deficiency of COX-1 but restored by ..
  6. Natesh K, Bhosale D, Desai A, Chandrika G, Pujari R, Jagtap J, et al. Oncostatin-M differentially regulates mesenchymal and proneural signature genes in gliomas via STAT3 signaling. Neoplasia. 2015;17:225-37 pubmed publisher
    ..Analysis of TCGA and REMBRANDT data revealed that expression of OSMR but not IL-6R or LIFR is upregulated in GBM and has negative correlation with survival...
  7. Peláez García A, Barderas R, Batlle R, Viñas Castells R, Bartolomé R, Torres S, et al. A proteomic analysis reveals that Snail regulates the expression of the nuclear orphan receptor Nuclear Receptor Subfamily 2 Group F Member 6 (Nr2f6) and interleukin 17 (IL-17) to inhibit adipocyte differentiation. Mol Cell Proteomics. 2015;14:303-15 pubmed publisher
    ..Among other proteins, multiple transcription factors such as Trip4, OsmR, Nr2f6, Cbx6, and Prrx1 were down-regulated...
  8. Martins K, Haas C, Ferst J, Rovani M, Goetten A, Duggavathi R, et al. Oncostatin M and its receptors mRNA regulation in bovine granulosa and luteal cells. Theriogenology. 2019;125:324-330 pubmed publisher
    Oncostatin M (OSM) and its receptor (OSMR) are members of the interleukin-6 family cytokines...
  9. Adrian Segarra J, Sreenivasan K, Gajawada P, Lörchner H, Braun T, Pöling J. The AB loop of oncostatin M (OSM) determines species-specific signaling in humans and mice. J Biol Chem. 2018;293:20181-20199 pubmed publisher
    ..of two different heterodimeric receptor complexes, formed by glycoprotein 130 (gp130) and either OSM receptor (OSMR) or leukemia inhibitory factor receptor (LIFR)...
  10. Mao B, Yao X, Wang Z, Zhao X. [Identification of pathogenic mutations in two Chinese families affected with primary localized cutaneous amyloidosis]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2018;35:9-13 pubmed publisher
    ..All of the 17 exons and their flanking splicing sites of the OSMR gene were amplified with PCR and subjected to Sanger sequencing...
  11. Losi L, Fonda S, Saponaro S, Chelbi S, Lancellotti C, Gozzi G, et al. Distinct DNA Methylation Profiles in Ovarian Tumors: Opportunities for Novel Biomarkers. Int J Mol Sci. 2018;19: pubmed publisher
    ..Furthermore, a promising relationship between hypermethylation of MGMT, OSMR, ESR1, and FOXL2 and overall survival was observed...
  12. Gotherstrom C, Chan J, O Donoghue K, Fisk N. Identification of candidate surface antigens for non-invasive prenatal diagnosis by comparative global gene expression on human fetal mesenchymal stem cells. Mol Hum Reprod. 2010;16:472-80 pubmed publisher
    ..Surface expression of OSMR and COL1 proteins on all fMSC, but no maternal PBL was confirmed...
  13. Janssens K, Maheshwari A, Van den Haute C, Baekelandt V, Stinissen P, Hendriks J, et al. Oncostatin M protects against demyelination by inducing a protective microglial phenotype. Glia. 2015;63:1729-37 pubmed publisher
    ..In this study, we reveal that the OSM receptor (OSMR) was robustly upregulated on microglia/macrophages and astrocytes in the cuprizone-induced demyelination model...
  14. Coleman N. Virus and Host Events in Squamous Carcinogenesis. Keio J Med. 2016;65:78 pubmed publisher
    ..2. The oncostatin-M receptor (OSMR) in metastasisThe cell-surface oncostatin-M receptor (OSMR) has emerged as an exciting therapeutic target in SCCs...
  15. Guihard P, Boutet M, Brounais Le Royer B, Gamblin A, Amiaud J, Renaud A, et al. Oncostatin m, an inflammatory cytokine produced by macrophages, supports intramembranous bone healing in a mouse model of tibia injury. Am J Pathol. 2015;185:765-75 pubmed publisher
    ..In addition, mice deficient in the mOSM receptor (Osmr(-/-)) also had reduced bone formation and osteoblast number within the injury site...
  16. Adrian Segarra J, Schindler N, Gajawada P, Lörchner H, Braun T, Pöling J. The AB loop and D-helix in binding site III of human Oncostatin M (OSM) are required for OSM receptor activation. J Biol Chem. 2018;293:7017-7029 pubmed publisher
    ..However, only OSM activates the OSM receptor (OSMR)-gp130 complex. The molecular features that enable OSM to specifically activate the OSMR are currently unknown...
  17. Dai X, Peng Y, Zhou B, Li C, Song H, Dou Q, et al. [Association of OSMR gene polymorphisms with dilated cardiomyopathy in a Han Chinese population]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2018;35:210-214 pubmed publisher
    To assess the association of polymorphisms of oncostatin M receptor (OSMR) gene with dilated cardiomyopathy (DCM) in a Han Chinese population...
  18. Ehlting C, Böhmer O, Hahnel M, Thomas M, Zanger U, Gaestel M, et al. Oncostatin M regulates SOCS3 mRNA stability via the MEK-ERK1/2-pathway independent of p38(MAPK)/MK2. Cell Signal. 2015;27:555-67 pubmed publisher
    ..and in primary human and murine hepatocytes, but not in macrophages because the latter lack the OSM receptor (OSMR)β subunit...
  19. Luo X, Liu Q, Yang H, Tan Q, Gan L, Ren F, et al. OSMR gene effect on the pathogenesis of chronic autoimmune Urticaria via the JAK/STAT3 pathway. Mol Med. 2018;24:28 pubmed publisher
    ..for CAU, the current study was performed to investigate the possible functioning of the Oncostatin M receptor (OSMR) gene in the autoimmunity of CAU via regulation of the JAK/STAT3 signaling pathway...
  20. Lai T, Wu D, Li W, Chen M, Yi Z, Huang D, et al. Interleukin-31 expression and relation to disease severity in human asthma. Sci Rep. 2016;6:22835 pubmed publisher
    ..Expressions of IL-31 and IL-31 receptor (IL-31RA and OSMR) were more prominent in the bronchial tissue in severe compared to mild asthma and controls...
  21. Al Quraishy S, Dkhil M, Abdel Baki A, Delic D, Wunderlich F. Protective vaccination alters gene expression of the liver of Balb/c mice in response to early prepatent blood-stage malaria of Plasmodium chabaudi. Parasitol Res. 2018;117:1115-1129 pubmed publisher
    ..Moreover, the IL-18 decoy receptor gene Il18bp, Gzmb, the genes Lif and Osmr encoding proteins of the IL-6 family, and the taurine transporter gene Slc6a6 were expressed >?3-fold in ..
  22. Raap U, Gehring M, Kleiner S, Rüdrich U, Eiz Vesper B, Haas H, et al. Human basophils are a source of - and are differentially activated by - IL-31. Clin Exp Allergy. 2017;47:499-508 pubmed publisher
    ..Oncostatin M receptor (OSMR), IL-31 receptor A (RA) and IL-31 protein expressions were analysed on human basophils from healthy donors...
  23. Elks C, Zhao P, Grant R, Hang H, Bailey J, Burk D, et al. Loss of Oncostatin M Signaling in Adipocytes Induces Insulin Resistance and Adipose Tissue Inflammation in Vivo. J Biol Chem. 2016;291:17066-76 pubmed publisher
    ..The OSM-specific receptor, OSM receptor ? (OSMR), is expressed in adipocytes, but its function remains largely unknown...
  24. Smigiel J, Parameswaran N, Jackson M. Potent EMT and CSC Phenotypes Are Induced By Oncostatin-M in Pancreatic Cancer. Mol Cancer Res. 2017;15:478-488 pubmed publisher
    ..OSM induced the expression of ZEB1, Snail (SNAI1), and OSM receptor (OSMR), engaging a positive feedback loop to potentiate the mesenchymal/CSC program...
  25. Walker E, Johnson R, Hu Y, Brennan H, Poulton I, Zhang J, et al. Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass. J Biol Chem. 2016;291:21703-21716 pubmed
    ..In contrast, murine OSM (mOSM) signals mainly via an OSM receptor (OSMR)-gp130 heterodimer and binds with only very low affinity to mLIFR...
  26. Moidunny S, Matos M, Wesseling E, Banerjee S, Volsky D, Cunha R, et al. Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity. J Neuroinflammation. 2016;13:144 pubmed publisher
    ..murine cells (EcoHIV/NL4-3-GFP virus (EcoHIV)) was used to investigate whether the virus induces OSM, OSM receptor (OSMR)-β, glycoprotein 130 (gp130), GLT-1, GLAST (mRNA and protein), and OSM release (ELISA) in cultured BV2 cells, ..
  27. Anastasiou R, Driessche G, Boutou E, Kazou M, Alexandraki V, Vorgias C, et al. Engineered strains of Streptococcus macedonicus towards an osmotic stress resistant phenotype retain their ability to produce the bacteriocin macedocin under hyperosmotic conditions. J Biotechnol. 2015;212:125-33 pubmed publisher
    ..0%w/v). The thermosensitive plasmid pGh9:ISS1 was employed to generate osmotic stress resistant (osmr) mutants of S. macedonicus...
  28. Qi L, Huang C, Wu X, Tao Y, Yan J, Shi T, et al. Hierarchical Specification of Pruriceptors by Runt-Domain Transcription Factor Runx1. J Neurosci. 2017;37:5549-5561 pubmed publisher
    ..itch manifestation, including the interleukin-31 receptor A (IL-31ra) and its coreceptor oncostatin M receptor (Osmr), the cysteinyl leukotriene receptor 2 (Cysltr2), somatostatin, and neurotensin...
  29. He P, Sun L, Zhu D, Zhang H, Zhang L, Guo Y, et al. Knock-Down of Endogenous Bornavirus-Like Nucleoprotein 1 Inhibits Cell Growth and Induces Apoptosis in Human Oligodendroglia Cells. Int J Mol Sci. 2016;17:435 pubmed publisher
    ..The top 10 most upregulated genes were PI3, RND3, BLZF1, SOD2, EPGN, SBSN, INSIG1, OSMR, CREB3L2, and MSMO1, and the top 10 most-downregulated genes were KRTAP2-4, FLRT2, DIDO1, FAT4, ESCO2, ZNF804A, ..
  30. Qi X, Zhao J, Cao Z, Fu E, Li F, Zhao Y, et al. The Clinical Spectrum of Multiple Endocrine Neoplasia Type 2A with Cutaneous Lichen Amyloidosis in Ethnic Han Chinese. Cancer Invest. 2018;36:141-151 pubmed publisher
    ..relationship between the multiple endocrine neoplasia type 2A (MEN 2A)-cutaneous lichen amyloidosis (CLA) and RET/OSMR/IL31RA mutations...
  31. Ma J, Yang Q, Deng C, Jin H, Gong W, Wang S, et al. [Screening and diagnostic value of the molecular markers of DNA methylation in colorectal neoplasma]. Zhonghua Wei Chang Wai Ke Za Zhi. 2015;18:1149-53 pubmed
    ..Methylation status of 8 genes, such as SNCA, MAL, INA, SPG20, FBN1, CNRIP1, TFPI2, OSMR, was detected by BSP and qMSP to screen genes with potential diagnostic valua...
  32. Caffarel M, Chattopadhyay A, Araujo A, Bauer J, Scarpini C, Coleman N. Tissue transglutaminase mediates the pro-malignant effects of oncostatin M receptor over-expression in cervical squamous cell carcinoma. J Pathol. 2013;231:168-79 pubmed publisher
    Oncostatin M receptor (OSMR) is commonly over-expressed in advanced cervical squamous cell carcinoma (SCC), producing a significantly worse clinical outcome...
  33. Zhang X, Li J, Qin J, Cheng W, Zhu X, Gong F, et al. Oncostatin M receptor β deficiency attenuates atherogenesis by inhibiting JAK2/STAT3 signaling in macrophages. J Lipid Res. 2017;58:895-906 pubmed publisher
    ..cytokine mainly involved in chronic inflammatory and cardiovascular diseases through binding to OSM receptor β (OSMR-β)...
  34. Ito K, Noguchi A, Uosaki Y, Taga T, Arakawa H, Takizawa T. Gfap and Osmr regulation by BRG1 and STAT3 via interchromosomal gene clustering in astrocytes. Mol Biol Cell. 2018;29:209-219 pubmed publisher
    ..remodeling factor, and the transcription factor STAT3 are required for Gfap and oncostatin M receptor (Osmr) clustering and enhanced expression through recruitment to STAT3 recognition sequences and that gene clustering ..
  35. Jahani Asl A, Yin H, Soleimani V, Haque T, Luchman H, Chang N, et al. Control of glioblastoma tumorigenesis by feed-forward cytokine signaling. Nat Neurosci. 2016;19:798-806 pubmed publisher
    EGFRvIII-STAT3 signaling is important in glioblastoma pathogenesis. Here, we identified the cytokine receptor OSMR as a direct target gene of the transcription factor STAT3 in mouse astrocytes and human brain tumor stem cells (BTSCs)...
  36. Diveu C, Venereau E, Froger J, Ravon E, Grimaud L, Rousseau F, et al. Molecular and functional characterization of a soluble form of oncostatin M/interleukin-31 shared receptor. J Biol Chem. 2006;281:36673-82 pubmed
    ..the cytokine to either type I OSM receptor (leukemia inhibitory factor receptor/gp130) or to type II OSM receptor (OSMR/gp130)...
  37. Li R, Wen R, Banzon T, Maminishkis A, Miller S. CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium. PLoS ONE. 2011;6:e23148 pubmed publisher
    ..Cultured hfRPE express CNTF, CT1, and OsM and their receptors, including CNTFR?, LIFR?, gp130, and OsMR?, all localized mainly at the apical membrane...
  38. Pelak K, Goldstein D, Walley N, Fellay J, Ge D, Shianna K, et al. Host determinants of HIV-1 control in African Americans. J Infect Dis. 2010;201:1141-9 pubmed publisher
  39. Kim M, Louwagie J, Carvalho B, Terhaar Sive Droste J, Park H, Chae Y, et al. Promoter DNA methylation of oncostatin m receptor-beta as a novel diagnostic and therapeutic marker in colon cancer. PLoS ONE. 2009;4:e6555 pubmed publisher
    ..Based on these results, we then examined the methylation frequency of Oncostatin M receptor-beta (OSMR) in a larger number of tissue and stool DNA samples collected from colon cancer patients and controls...
  40. Babilas P, Fiebig B, Aslanidis C, Hansen J, Rocken C, Schroeder J, et al. Identification of an oncostatin M receptor mutation associated with familial primary cutaneous amyloidosis. Br J Dermatol. 2009;161:944-7 pubmed publisher
  41. Hermanns H. Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology. Cytokine Growth Factor Rev. 2015;26:545-58 pubmed publisher
    ..two cytokines belonging to the IL-6 family which share a common signaling receptor subunit, the OSM receptor beta (OSMRβ)...
  42. West N, Hegazy A, Owens B, Bullers S, Linggi B, Buonocore S, et al. Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease. Nat Med. 2017;23:579-589 pubmed publisher
    ..intestinal tissues from patients with IBD express high amounts of the cytokine oncostatin M (OSM) and its receptor (OSMR), which correlate closely with histopathological disease severity...
  43. Banos G, Bramis G, Bush S, Clark E, McCulloch M, Smith J, et al. The genomic architecture of mastitis resistance in dairy sheep. BMC Genomics. 2017;18:624 pubmed publisher
    ..Relevant candidate genes implicated in innate immunity included SOCS2, CTLA4, C6, C7, C9, PTGER4, DAB2, CARD6, OSMR, PLXNC1, IDH1, ICOS, FYB, and LYFR...
  44. Savarese T, Campbell C, McQuain C, Mitchell K, Guardiani R, Quesenberry P, et al. Coexpression of oncostatin M and its receptors and evidence for STAT3 activation in human ovarian carcinomas. Cytokine. 2002;17:324-34 pubmed
    ..oncostatin M and LIF, and a second heterocomplex consisting of a subunit that specifically recognizes oncostatin M, OSMR beta, and the gp130 protein...
  45. Grant S, Hammacher A, Douglas A, Goss G, Mansfield R, Heath J, et al. An unexpected biochemical and functional interaction between gp130 and the EGF receptor family in breast cancer cells. Oncogene. 2002;21:460-74 pubmed
    ..This provides a new mechanism for generating signalling diversity and has potential clinical implications in breast cancer. ..
  46. Luyckx V, Cairo L, Compston C, Phan W, Mueller T. Oncostatin M pathway plays a major role in the renal acute phase response. Am J Physiol Renal Physiol. 2009;296:F875-83 pubmed publisher
    ..response in the deceased donor kidney, associated with a significant upregulation of oncostatin M receptor beta (OSMR)...
  47. Arita K, Abe R, Baba K, McGrath J, Akiyama M, Shimizu H. A novel OSMR mutation in familial primary localized cutaneous amyloidosis in a Japanese family. J Dermatol Sci. 2009;55:64-5 pubmed publisher
  48. Radtke S, Hermanns H, Haan C, Schmitz Van de Leur H, Gascan H, Heinrich P, et al. Novel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression. J Biol Chem. 2002;277:11297-305 pubmed
    The oncostatin M receptor (OSMR) is part of a heterodimeric receptor complex that mediates signal transduction of the pleiotropic cytokine OSM via a signaling pathway involving Janus kinases (Jaks) and transcription factors of the signal ..
  49. Hintzen C, Evers C, Lippok B, Volkmer R, Heinrich P, Radtke S, et al. Box 2 region of the oncostatin M receptor determines specificity for recruitment of Janus kinases and STAT5 activation. J Biol Chem. 2008;283:19465-77 pubmed publisher
    ..OSM) induce their bioactivities through a heterodimeric receptor complex consisting of gp130 and the OSM receptor (OSMR), which initiates a signaling pathway involving Janus kinases (JAKs) and transcription factors of the signal ..
  50. Wang W, Zhao Z, Wu F, Wang H, Wang J, Lan Q, et al. Bioinformatic analysis of gene expression and methylation regulation in glioblastoma. J Neurooncol. 2018;136:495-503 pubmed publisher
    ..An eight-gene (C9orf64, OSMR, MDK, MARVELD1, PTRF, MYD88, BIRC3, RPP25) signature was established to divide GBM patients into two groups based ..
  51. Torossian F, Guerton B, Anginot A, Alexander K, Desterke C, Soave S, et al. Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications. JCI Insight. 2017;2: pubmed publisher
    ..The key role of OSM was confirmed using an experimental model of NHO in mice defective for the OSM receptor (OSMR)...
  52. Cichy J, Rose John S, Pure E. Regulation of the type II oncostatin M receptor expression in lung-derived epithelial cells. FEBS Lett. 1998;429:412-6 pubmed
    ..Therefore, we characterized lung-derived epithelial cells for the expression of type II OSM receptor mRNAs, and the regulation of the mRNAs encoding the components of the OSM-specific receptor by cytokines and dexamethasone. ..
  53. Guo S, Li Z, Gong J, Xiang M, Zhang P, Zhao G, et al. Oncostatin M Confers Neuroprotection against Ischemic Stroke. J Neurosci. 2015;35:12047-62 pubmed publisher
    ..Here, we report that human OSM is neuroprotective in vivo and in vitro by recruiting OSMRβ in the setting of ischemic stroke...
  54. Hermanns H, Radtke S, Haan C, Schmitz Van de Leur H, Tavernier J, Heinrich P, et al. Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130. J Immunol. 1999;163:6651-8 pubmed
    ..factor, and oncostatin M (OSM) lead to heterodimerization of LIF receptor (LIFR) or the OSM-specific receptor (OSMR) with glycoprotein (gp) 130, the common receptor subunit for IL-6-type cytokines...
  55. Chollangi S, Mather T, Rodgers K, Ash J. A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptor. J Biol Chem. 2012;287:32848-59 pubmed
    ..heterodimers of gp130 with either leukemia inhibitory factor receptor (LIFR) (type I) or oncostatin M receptor (OSMR) (type II)...
  56. Hams E, Colmont C, Dioszeghy V, Hammond V, Fielding C, Williams A, et al. Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation. J Immunol. 2008;181:2174-80 pubmed
    ..compared with wild-type and IL-6-deficient mice, peritoneal inflammation in oncostatin M receptor-beta-deficient (OSMR-KO) mice resulted in enhanced monocytic cell trafficking...
  57. Devor E, Reyes H, Gonzalez Bosquet J, Warrier A, Kenzie S, Ibik N, et al. Placenta-Specific Protein 1 Expression in Human Papillomavirus 16/18-Positive Cervical Cancers Is Associated With Tumor Histology. Int J Gynecol Cancer. 2017;27:784-790 pubmed publisher
    ..This preliminary study has further revealed a complex relationship between PLAC1 expression, cervical cancer histologic type, p53, and HPV type that requires further investigation. ..
  58. Wali A, Liu L, Takeichi T, Jelani M, Rahman O, Heng Y, et al. Familial primary localized cutaneous amyloidosis results from either dominant or recessive mutations in OSMR. Acta Derm Venereol. 2015;95:1005-7 pubmed publisher
  59. Kanda N, Watanabe S. Increased serum human β-defensin-2 levels in atopic dermatitis: relationship to IL-22 and oncostatin M. Immunobiology. 2012;217:436-45 pubmed publisher
    ..IL-22 and oncostatin M may enhance hBD-2 production via STAT3 in keratinocytes, while hBD-2 may enhance IL-22 and oncostatin M production in T cells. hBD-3 may enhance T(H)2 responses. ..
  60. Blanchard F, Wang Y, Kinzie E, Duplomb L, Godard A, Baumann H. Oncostatin M regulates the synthesis and turnover of gp130, leukemia inhibitory factor receptor alpha, and oncostatin M receptor beta by distinct mechanisms. J Biol Chem. 2001;276:47038-45 pubmed
    ..Proteosomal degradation appears to involve a fraction of receptor subunit proteins that are ubiquitinated independently of ligand binding. ..
  61. Ferretti E, Tripodo C, Pagnan G, Guarnotta C, Marimpietri D, Corrias M, et al. The interleukin (IL)-31/IL-31R axis contributes to tumor growth in human follicular lymphoma. Leukemia. 2015;29:958-67 pubmed publisher
    Interleukin (IL)-31A binds to an heterodimer composed of IL-31 receptor A (IL-31RA) and Oncostatin M Receptor (OSMR). The IL-31/IL-31R complex is involved in the pathogenesis of various skin diseases, including cutaneous T-cell lymphoma...
  62. Shien K, Papadimitrakopoulou V, Ruder D, Behrens C, Shen L, Kalhor N, et al. JAK1/STAT3 Activation through a Proinflammatory Cytokine Pathway Leads to Resistance to Molecularly Targeted Therapy in Non-Small Cell Lung Cancer. Mol Cancer Ther. 2017;16:2234-2245 pubmed publisher
    ..The selective JAK1 inhibitor filgotinib effectively suppressed STAT3 activation and OSMR expression, and cotargeting inhibition of the oncogenic pathway and JAK1 reversed resistance to targeted drugs...
  63. Qi X, Zhao J, Chen Z, Cao J, Du J, Liu N, et al. RET mutation p.S891A in a Chinese family with familial medullary thyroid carcinoma and associated cutaneous amyloidosis binding OSMR variant p.G513D. Oncotarget. 2015;6:33993-4003 pubmed publisher
    ..between familial medullary thyroid carcinoma (FMTC) associated with cutaneous amyloidosis (CA) and RET or OSMR/IL31RA gene mutations. In this study, we investigated a Chinese family with FMTC/CA and found a recurrent RET c...
  64. Ruprecht K, Kuhlmann T, Seif F, Hummel V, Kruse N, Bruck W, et al. Effects of oncostatin M on human cerebral endothelial cells and expression in inflammatory brain lesions. J Neuropathol Exp Neurol. 2001;60:1087-98 pubmed
    ..Using RT-PCR we detected transcripts of the receptor components involved in OSM signaling, gp130, OSM receptor (OSMR)-beta, and leukemia inhibitory factor receptor (LIFR), in HCEC...
  65. Kausar T, Sharma R, Hasan M, Saraya A, Chattopadhyay T, Gupta S, et al. Overexpression of a splice variant of oncostatin M receptor beta in human esophageal squamous carcinoma. Cell Oncol (Dordr). 2011;34:177-87 pubmed publisher
    Expression of oncostatin M receptor beta (OSMR?) has been reported in human cancers, however its role in esophageal squamous cell carcinoma (ESCC) remains unknown...
  66. Saeedi M, Ebrahim Habibi A, Haghighi A, Zarrabi F, Amoli M, Robati R. A novel missense mutation in oncostatin M receptor beta causing primary localized cutaneous amyloidosis. Biomed Res Int. 2014;2014:653724 pubmed publisher
    ..Autosomal dominant PLCA has been mapped earlier to pathogenic missense mutations in the OSMR gene, which encodes the oncostatin M receptor ß subunit (OSMRß)...
  67. Abir R, Ao A, Jin S, Barnett M, van den Hurk R, Freimann S, et al. Immunocytochemical detection and reverse transcription polymerase chain reaction expression of oncostatin M (OSM) and its receptor (OSM-Rbeta) in human fetal and adult ovaries. Fertil Steril. 2005;83 Suppl 1:1188-96 pubmed
    ..Transcripts of OSM and OSM-Rbeta RNA were detected by RT-PCR analyses. The expression of OSM and its receptor in ovarian tissue from fetuses and women suggests a possible role of OSM in growth initiation of human primordial follicles. ..
  68. Larrea E, Echeverria I, Riezu Boj J, Aldabe R, Guembe L, Sola I, et al. Characterization of the CD40L/Oncostatin M/Oncostatin M receptor axis as an antiviral and immunostimulatory system disrupted in chronic HCV infection. J Hepatol. 2014;60:482-9 pubmed publisher
    ..M (OSM) is an inflammatory cytokine which interacts with a heterodimeric receptor formed by gp130 and either OSMR? or LIFR...
  69. Deller M, Hudson K, Ikemizu S, Bravo J, Jones E, Heath J. Crystal structure and functional dissection of the cytostatic cytokine oncostatin M. Structure. 2000;8:863-74 pubmed
    ..via specific binding to gp130 and either the leukaemia inhibitory factor receptor (LIFR) or oncostatin M receptor (OSMR) systems at the cell surface to form an active signalling complex...
  70. Lin Y, Li R, Lin C, Ou T, Wu C, Tsai W, et al. Association of OSMR gene polymorphisms with rheumatoid arthritis and systemic lupus erythematosus patients. Autoimmunity. 2014;47:23-6 pubmed publisher
    Cytokines are involved in the pathogenesis of autoimmune diseases. Oncostatin M receptor (OSMR) activates JAK/STAT and MAPK pathways leading to the stimulation of a variety of cytokines and inflammatory substances...
  71. Kucia Tran J, Tulkki V, Smith S, Scarpini C, Hughes K, Araujo A, et al. Overexpression of the oncostatin-M receptor in cervical squamous cell carcinoma is associated with epithelial-mesenchymal transition and poor overall survival. Br J Cancer. 2016;115:212-22 pubmed publisher
    Copy-number gain of the oncostatin-M receptor (OSMR) occurs frequently in cervical squamous cell carcinoma (SCC) and is associated with adverse clinical outcome...
  72. Auguste P, Guillet C, Fourcin M, Olivier C, Veziers J, Pouplard Barthelaix A, et al. Signaling of type II oncostatin M receptor. J Biol Chem. 1997;272:15760-4 pubmed
    ..OSMRbeta type II heterocomplex. The signaling pathway differences observed between the common type I LIF/OSM receptor and the specific type II OSM receptor might explain some of the bioactivities specifically displayed by OSM. ..
  73. Kucia Tran J, Tulkki V, Scarpini C, Smith S, Wallberg M, Pàez Ribes M, et al. Anti-oncostatin M antibody inhibits the pro-malignant effects of oncostatin M receptor over-expression in squamous cell carcinoma. J Pathol. 2017;: pubmed publisher
    The oncostatin M receptor (OSMR) shows frequent gene copy-number gain and over-expression in cervical squamous cell carcinomas (SCCs), associated with adverse clinical outcomes...
  74. Hibi K, Goto T, Sakuraba K, Shirahata A, Saito M, Ishibashi K, et al. Methylation of OSMR gene is frequently observed in non-invasive colorectal cancer. Anticancer Res. 2011;31:1293-5 pubmed
    Recently, it has been reported that oncostatin M receptor-? (OSMR) is frequently methylated in primary colon cancer tissues, but not in normal tissues...