ORMDL3

Summary

Gene Symbol: ORMDL3
Description: ORMDL sphingolipid biosynthesis regulator 3
Alias: ORM1-like protein 3
Species: human
Products:     ORMDL3

Top Publications

  1. Hjelmqvist L, Tuson M, Marfany G, Herrero E, Balcells S, Gonzalez Duarte R. ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins. Genome Biol. 2002;3:RESEARCH0027 pubmed
    ..a new gene, ORMDL1, that belongs to a novel gene family comprising three genes in humans (ORMDL1, ORMDL2 and ORMDL3), and homologs in yeast, microsporidia, plants, Drosophila, urochordates and vertebrates...
  2. Verlaan D, Berlivet S, Hunninghake G, Madore A, Larivière M, Moussette S, et al. Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. Am J Hum Genet. 2009;85:377-93 pubmed publisher
    ..by us and others have linked the disease-associated genetic variants with changes in expression of GSDMB and ORMDL3 transcripts in human lymphoblastoid cell lines (LCLs)...
  3. Ferreira M, McRae A, Medland S, Nyholt D, Gordon S, Wright M, et al. Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia. Eur J Hum Genet. 2011;19:458-64 pubmed publisher
    ..new variants associated with asthma and attempt to replicate the association with four loci reported previously (ORMDL3, PDE4D, DENND1B and IL1RL1)...
  4. Galanter J, Choudhry S, Eng C, Nazario S, Rodriguez Santana J, Casal J, et al. ORMDL3 gene is associated with asthma in three ethnically diverse populations. Am J Respir Crit Care Med. 2008;177:1194-200 pubmed publisher
    ..A whole-genome association study identified ORMDL3 as a promising candidate gene for asthma in white populations...
  5. Tavendale R, Macgregor D, Mukhopadhyay S, Palmer C. A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications. J Allergy Clin Immunol. 2008;121:860-3 pubmed publisher
    ..association study suggested that single nucleotide polymorphisms at loci controlling the expression of the ORMDL3 gene and others in the neighborhood of the NRG1 and ERO1LB genes might be important...
  6. Moffatt M, Gut I, Demenais F, Strachan D, Bouzigon E, Heath S, et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med. 2010;363:1211-1221 pubmed publisher
    ..1×10(−8)). Association with the ORMDL3/GSDMB locus on chromosome 17q21 was specific to childhood-onset disease (rs2305480, P=6×10(−23))...
  7. Miller M, Tam A, Cho J, Doherty T, Pham A, Khorram N, et al. ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6. Proc Natl Acad Sci U S A. 2012;109:16648-53 pubmed publisher
    Orosomucoid like 3 (ORMDL3) has been strongly linked with asthma in genetic association studies, but its function in asthma is unknown...
  8. McGovern D, Gardet A, Törkvist L, Goyette P, Essers J, Taylor K, et al. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet. 2010;42:332-7 pubmed publisher
    ..with ulcerative colitis (P < 5 x 10(-8)), including the immunoglobulin receptor gene FCGR2A, 5p15, 2p16 and ORMDL3 (orosomucoid1-like 3)...
  9. Liu X, Invernizzi P, Lu Y, Kosoy R, Lu Y, Bianchi I, et al. Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. Nat Genet. 2010;42:658-60 pubmed publisher
    ..9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38). ..

More Information

Publications112 found, 100 shown here

  1. Lluis A, Schedel M, Liu J, Illi S, Depner M, von Mutius E, et al. Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion. J Allergy Clin Immunol. 2011;127:1587-94.e6 pubmed publisher
    ..genetic variants on chromosome 17q21 were strongly associated with childhood asthma and orosomucoid 1-like 3 (ORMDL3) gene expression...
  2. Wu H, Romieu I, Sienra Monge J, Li H, del Rio Navarro B, London S. Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma. Allergy. 2009;64:629-35 pubmed publisher
    A genome-wide association study identified ORM1-like 3 (orosomucoid 1-like 3, ORMDL3) as an asthma candidate gene...
  3. Breslow D, Collins S, Bodenmiller B, Aebersold R, Simons K, Shevchenko A, et al. Orm family proteins mediate sphingolipid homeostasis. Nature. 2010;463:1048-53 pubmed publisher
    ..in sphingolipid metabolism of the ORM genes (known as ORMDL genes in humans)-a conserved gene family that includes ORMDL3, which has recently been identified as a potential risk factor for childhood asthma...
  4. Berlivet S, Moussette S, Ouimet M, Verlaan D, Koka V, Al Tuwaijri A, et al. Interaction between genetic and epigenetic variation defines gene expression patterns at the asthma-associated locus 17q12-q21 in lymphoblastoid cell lines. Hum Genet. 2012;131:1161-71 pubmed publisher
    ..17q12-q21 harbors three genes, the zona pellucida binding protein 2 (ZPBP2), gasdermin B (GSDMB) and ORM1-like 3 (ORMDL3), that show allele-specific differences in expression levels in lymphoblastoid cell lines (LCLs) and CD4+ T cells...
  5. Berce V, Kozmus C, Potocnik U. Association among ORMDL3 gene expression, 17q21 polymorphism and response to treatment with inhaled corticosteroids in children with asthma. Pharmacogenomics J. 2013;13:523-9 pubmed publisher
    ..association studies linked childhood asthma with single-nucleotide polymorphisms (SNPs) in ORM1-like protein 3 (ORMDL3) gene region on chromosome 17q21...
  6. Moffatt M, Kabesch M, Liang L, Dixon A, Strachan D, Heath S, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature. 2007;448:470-3 pubmed
    ..with childhood asthma were consistently and strongly associated (P < 10(-22)) in cis with transcript levels of ORMDL3, a member of a gene family that encodes transmembrane proteins anchored in the endoplasmic reticulum...
  7. Hirota T, Harada M, Sakashita M, Doi S, Miyatake A, Fujita K, et al. Genetic polymorphism regulating ORM1-like 3 (Saccharomyces cerevisiae) expression is associated with childhood atopic asthma in a Japanese population. J Allergy Clin Immunol. 2008;121:769-70 pubmed
  8. Halapi E, Gudbjartsson D, Jonsdottir G, Bjornsdottir U, Thorleifsson G, Helgadottir H, et al. A sequence variant on 17q21 is associated with age at onset and severity of asthma. Eur J Hum Genet. 2010;18:902-8 pubmed publisher
    A sequence variant (rs7216389-T) near the ORMDL3 gene on chromosome 17q21 was recently found to be associated with childhood asthma...
  9. Carreras Sureda A, Cantero Recasens G, Rubio Moscardo F, Kiefer K, Peinelt C, Niemeyer B, et al. ORMDL3 modulates store-operated calcium entry and lymphocyte activation. Hum Mol Genet. 2013;22:519-30 pubmed publisher
    ..Here, we report that the ER protein orosomucoid like 3 (ORMDL3), the product of the ORMDL3 gene associated with several autoimmune and/or inflammatory diseases, negatively ..
  10. Zhuang L, Jin R, Zhu L, Xu H, Li Y, Gao S, et al. Promoter characterization and role of cAMP/PKA/CREB in the basal transcription of the mouse ORMDL3 gene. PLoS ONE. 2013;8:e60630 pubmed publisher
    Orosomucoid 1-like 3 (ORMDL3) gene was strongly linked with the development of asthma in genetic association studies, and its expression could be significantly induced by allergen in airway epithelial cells of mice...
  11. Cantero Recasens G, Fandos C, Rubio Moscardo F, Valverde M, Vicente R. The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress. Hum Mol Genet. 2010;19:111-21 pubmed publisher
    ..Here we identified that ORMDL3, the only genetic risk factor recently associated to asthma in a genome wide study, alters ER-mediated Ca(2+) ..
  12. Nalls M, Couper D, Tanaka T, van Rooij F, Chen M, Smith A, et al. Multiple loci are associated with white blood cell phenotypes. PLoS Genet. 2011;7:e1002113 pubmed publisher
    ..count and five WBC subtypes at seven different genomic loci (total WBC count-6p21 in the HLA region, 17q21 near ORMDL3, and CSF3; neutrophil count-17q21; basophil count- 3p21 near RPN1 and C3orf27; lymphocyte count-6p21, 19p13 at ..
  13. Martinez F. Childhood Asthma Inception and Progression: Role of Microbial Exposures, Susceptibility to Viruses and Early Allergic Sensitization. Immunol Allergy Clin North Am. 2019;39:141-150 pubmed publisher
    ..The ORMDL3 asthma locus in chromosome 17q seems to exert its effects by increasing susceptibility to human rhinovirus in ..
  14. Kappel S, Borgström A, Stokłosa P, Dörr K, Peinelt C. Store-operated calcium entry in disease: Beyond STIM/Orai expression levels. Semin Cell Dev Biol. 2019;: pubmed publisher
    ..This review summarizes these regulatory mechanisms, including glycosylation, pH sensing, and the regulatory proteins golli, α-SNAP, SARAF, ORMDL3, CRACR2 A, and TRPM4 channels.
  15. Li X, Ampleford E, Howard T, Moore W, Torgerson D, Li H, et al. Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. J Allergy Clin Immunol. 2012;130:861-8.e7 pubmed publisher
    Genome-wide association studies (GWASs) of asthma have consistently implicated the ORM1-like 3 and gasdermin B (ORMDL3-GSDMB), IL33, IL-1 receptor-like 1 and IL-18 receptor 1 (IL1RL1-IL18R1), RAD50-IL13, thymic stromal lymphopoietin and ..
  16. Kelly R, Chawes B, Blighe K, Virkud Y, Croteau Chonka D, McGeachie M, et al. An Integrative Transcriptomic and Metabolomic Study of Lung Function in Children With Asthma. Chest. 2018;154:335-348 pubmed publisher
    ..correlated gene-metabolite modules expanded the single omic findings, linking the FEV1/FVC ratio with ORMDL3 and dysregulated lipid metabolism. This finding was replicated in an independent population...
  17. Zhang M, Wang T, Sirianni R, Shaul P, Xie Y. Identifying genes with tri-modal association with survival and tumor grade in cancer patients. BMC Bioinformatics. 2019;20:13 pubmed publisher
    ..We found one gene, ORMDL3, whose low and high modes were both associated with worse survival and higher tumor grade in breast cancer ..
  18. Lasky Su J, Himes B, Raby B, Klanderman B, Sylvia J, Lange C, et al. HLA-DQ strikes again: genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults. Clin Exp Allergy. 2012;42:1724-33 pubmed publisher
    ..g., ORMDL3, PDE4D, HLA-DQ, and TLE4) via genome-wide association studies...
  19. Kiefer K, Carreras Sureda A, García López R, Rubio Moscardó F, Casas J, Fabriàs G, et al. Coordinated regulation of the orosomucoid-like gene family expression controls de novo ceramide synthesis in mammalian cells. J Biol Chem. 2015;290:2822-30 pubmed publisher
    ..Single nucleotide polymorphisms (SNPs) that increase ORMDL3 expression have been associated with various immune/inflammatory diseases, although the pathophysiological ..
  20. Klaassen E, Penders J, Jöbsis Q, van de Kant K, Thijs C, Mommers M, et al. An ADAM33 polymorphism associates with progression of preschool wheeze into childhood asthma: a prospective case-control study with replication in a birth cohort study. PLoS ONE. 2015;10:e0119349 pubmed publisher
    ..In the ADEM study, the minor alleles of ADAM33 rs511898 and rs528557 and the ORMDL3/GSDMB rs7216389 polymorphisms were negatively associated, whereas the minor alleles of IL4 rs2243250 and rs2070874 ..
  21. Xiang S, Li M, Chan C, Shen Q, Chen S, An B, et al. Altered metabolites in guinea pigs with allergic asthma after acupoint sticking therapy: New insights from a metabolomics approach. Phytomedicine. 2019;54:182-194 pubmed publisher
    ..The mRNA expression levels of IL-4, IL-5, IL-13 and orosomucoid-like 3 (ORMDL3) were measured using quantitative reverse transcription polymerase chain reaction (RT-qPCR)...
  22. Zhang Y, Willis Owen S, Spiegel S, Lloyd C, Moffatt M, Cookson W. The ORMDL3 Asthma Gene Regulates ICAM1 and has Multiple Effects on Cellular Inflammation. Am J Respir Crit Care Med. 2018;: pubmed publisher
    ..Risk alleles positively correlate with ORMDL3 expression...
  23. Kantor D, Palmer C, Young T, Meng Y, Gajdos Z, Lyon H, et al. Replication and fine mapping of asthma-associated loci in individuals of African ancestry. Hum Genet. 2013;132:1039-47 pubmed publisher
    ..We also provide strong or nominal evidence of replication at loci near ORMDL3/GSDMB, IL1RL1/IL18R1, and 10p14, all previously associated with asthma in European or Japanese populations, but ..
  24. Cao Q, Juan C, Zhang D, He J, Cao Y, Pasha A, et al. STING positively regulates human ORMDL3 expression through TBK1-IRF3-STAT6 complex mediation. Exp Cell Res. 2018;370:498-505 pubmed publisher
    Orosomucoid 1-like protein 3 (ORMDL3) is an asthma candidate gene associated with virus-triggered recurrent wheeze. Stimulator of interferon gene (STING) controls TLR-independent cytosolic responses to viruses...
  25. Wu X, Li R, Zhang H, Jin R, Wang J, Juan C, et al. Methylation status of ORMDL3 regulates cytokine production and p-ERK/MMP9 pathway expression. Exp Cell Res. 2018;372:43-51 pubmed publisher
    Orosomucoid like-3 (ORMDL3) has been identified to be associated with the development of asthma according to previous studies. However, the definite role of ORMDL3 in the pathogenesis of asthma remains unclear...
  26. Miller M, Tam A, Mueller J, Rosenthal P, Beppu A, Gordillo R, et al. Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate. J Immunol. 2017;198:3017-3022 pubmed publisher
    In this study, we used cre-lox techniques to generate mice selectively deficient in ORMDL3 in airway epithelium (Ormdl3Δ2-3/Δ2-3/CC10) to simulate an inhaled therapy that effectively inhibited ORMDL3 expression in the ..
  27. Hitomi Y, Kojima K, Kawashima M, Kawai Y, Nishida N, Aiba Y, et al. Identification of the functional variant driving ORMDL3 and GSDMB expression in human chromosome 17q12-21 in primary biliary cholangitis. Sci Rep. 2017;7:2904 pubmed publisher
    ..of a functional variant in a primary biliary cholangitis (PBC)-susceptible region, chromosome 17q12-21 (ORMDL3-GSDMB-ZPBP2-IKZF3)...
  28. García Sánchez A, Isidoro García M, García Solaesa V, Sanz C, Hernández Hernández L, Padrón Morales J, et al. Genome-wide association studies (GWAS) and their importance in asthma. Allergol Immunopathol (Madr). 2015;43:601-8 pubmed publisher
    ..GWAS was published in 2007, and described a new locus associated to asthma in chromosome 17q12-q21, involving the ORMDL3, GSDMB and ZPBP2 genes (a description of the genes named in the manuscript are listed in Table 1)...
  29. van der Valk R, Duijts L, Timpson N, Salam M, Standl M, Curtin J, et al. Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. J Allergy Clin Immunol. 2014;134:46-55 pubmed publisher
    ..rs8069176 was associated with GSDMB and ORM1-like 3 (ORMDL3) expression. rs8069176 at 17q12-q21, but not rs3751972 and rs944722 at 17q11...
  30. Bugajev V, Hálová I, Dráberová L, Bambousková M, Potůčková L, Draberova H, et al. Negative regulatory roles of ORMDL3 in the FcεRI-triggered expression of proinflammatory mediators and chemotactic response in murine mast cells. Cell Mol Life Sci. 2016;73:1265-85 pubmed publisher
    ..Although mast cells are involved in the development of these diseases, the contribution of ORMDL3 to the mast cell physiology is unknown...
  31. Skieceviciene J, Kiudelis G, Ellinghaus E, Balschun T, Jonaitis L, Zvirbliene A, et al. Replication study of ulcerative colitis risk loci in a Lithuanian-Latvian case-control sample. Inflamm Bowel Dis. 2013;19:2349-55 pubmed publisher
    ..We found 14 SNPs tagging 9 loci, including 21q21.1, NKX2-3, MST1, the HLA region, 1p36.13, IL10, JAK2, ORMDL3, and IL23R, to be associated with UC...
  32. Yan Q, Brehm J, Pino Yanes M, Forno E, Lin J, Oh S, et al. A meta-analysis of genome-wide association studies of asthma in Puerto Ricans. Eur Respir J. 2017;49: pubmed publisher
    ..g. ZPBP2, ORMDL3 and GSDMB) were significantly associated with asthma in Puerto Ricans...
  33. Davis D, Kannan M, Wattenberg B. Orm/ORMDL proteins: Gate guardians and master regulators. Adv Biol Regul. 2018;70:3-18 pubmed publisher
    ..Finally, we discuss the intriguing connection between one of the mammalian ORMDL isoforms, ORMDL3, and the pervasive pulmonary disease, asthma, in humans.
  34. Zhang Y, Moffatt M, Cookson W. Genetic and genomic approaches to asthma: new insights for the origins. Curr Opin Pulm Med. 2012;18:6-13 pubmed publisher
    ..The largest of these was from the GABRIEL consortium, which discovered that the IL18R1, IL33, SMAD3, ORMDL3, HLA-DQ and IL2RB loci were all significantly associated with asthma...
  35. Zavbi M, Korosec P, Flezar M, Škrgat Kristan S, Marc Malovrh M, Rijavec M. Polymorphisms and haplotypes of the chromosome locus 17q12-17q21.1 contribute to adult asthma susceptibility in Slovenian patients. Hum Immunol. 2016;77:527-34 pubmed publisher
    ..Single SNP analysis revealed only marginal associations with adult asthma for SNPs located in GSDMA, GSDMB, ORMDL3 and ZPBP2 genes, and rs7219080 was the most highly associated...
  36. Oyeniran C, Sturgill J, Hait N, Huang W, Avni D, Maceyka M, et al. Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice. J Allergy Clin Immunol. 2015;136:1035-46.e6 pubmed publisher
    ..Genome-wide association studies have identified ORM (yeast)-like protein isoform 3 (ORMDL3) as a gene associated with susceptibility to asthma...
  37. Holm L, Krogvold L, Hasselby J, Kaur S, Claessens L, Russell M, et al. Abnormal islet sphingolipid metabolism in type 1 diabetes. Diabetologia. 2018;61:1650-1661 pubmed publisher
    ..Next, we discovered eight gene polymorphisms (ORMDL3, SPHK2, B4GALNT1, SLC1A5, GALC, PPARD, PPARG and B4GALT1) involved in sphingolipid metabolism that contribute to ..
  38. Sharma S, Zhou X, Thibault D, Himes B, LIU A, Szefler S, et al. A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes. J Allergy Clin Immunol. 2014;134:1153-62 pubmed publisher
    ..We confirmed the previously reported association of ORMDL3/GSDMB variants with asthma (combined P = 2.9 × 10(-8))...
  39. Moheimani F, Hsu A, Reid A, Williams T, Kicic A, Stick S, et al. The genetic and epigenetic landscapes of the epithelium in asthma. Respir Res. 2016;17:119 pubmed
    ..Some potential biomarkers are IRAKM, PCDH1, ORMDL3/GSDMB, IL-33, CDHR3 and CST1 in airway epithelial cells...
  40. Wiemels J, Walsh K, de Smith A, Metayer C, Gonseth S, Hansen H, et al. GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Nat Commun. 2018;9:286 pubmed publisher
    ..Here we identify new risk loci on 17q12 near IKZF3/ZPBP2/GSDMB/ORMDL3, a locus encompassing a transcription factor important for lymphocyte development (IKZF3), and at an 8q24 region ..
  41. Ober C, Yao T. The genetics of asthma and allergic disease: a 21st century perspective. Immunol Rev. 2011;242:10-30 pubmed publisher
    ..In contrast, variation at the 17q21 asthma locus, encoding the ORMDL3 and GSDML genes, is specifically associated with risk for childhood onset asthma...
  42. Lopez J, Albarrán L, Gómez L, Smani T, Salido G, Rosado J. Molecular modulators of store-operated calcium entry. Biochim Biophys Acta. 2016;1863:2037-43 pubmed publisher
    ..Here, we review our current understanding of some of the key modulators of STIM1-Orai1 interaction, including the proteins CRACR2A, STIMATE, SARAF, septins, golli and ORMDL3.
  43. Yu F, Sun Y, Yu J, Ding Z, Wang J, Zhang L, et al. ORMDL3 is associated with airway remodeling in asthma via the ERK/MMP-9 pathway. Mol Med Rep. 2017;15:2969-2976 pubmed publisher
    ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) has been previously implicated in asthma pathogenesis, its effect on airway remodeling remains to be elucidated...
  44. Stein M, Thompson E, Schoettler N, Helling B, Magnaye K, Stanhope C, et al. A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle. J Allergy Clin Immunol. 2018;142:749-764.e3 pubmed publisher
    ..core region defined by the first genome-wide association study correlate with expression of 2 genes, ORM1-like 3 (ORMDL3) and gasdermin B (GSDMB), making these prime candidate asthma genes, although recent studies have implicated ..
  45. Tripathi P, Deng F, Scruggs A, Chen Y, Huang S. Variation in doses and duration of particulate matter exposure in bronchial epithelial cells results in upregulation of different genes associated with airway disorders. Toxicol In Vitro. 2018;51:95-105 pubmed publisher
    ..5 increased the expression of IL6, TNF, TSLP, CSF2, PTGS2, IL4R, and SPINK5. Other genes such as ADAM33, ORMDL3, DPP10 and CYP1A1, however, were increased by PM2.5 at much lower doses (≤1 μg/cm2)...
  46. Granell R, Henderson A, Timpson N, St Pourcain B, Kemp J, Ring S, et al. Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes. J Allergy Clin Immunol. 2013;131:685-94 pubmed publisher
    Genome-wide association studies have identified associations of genetic variants at 17q21 near ORMDL3 with childhood asthma...
  47. Löser S, Gregory L, Zhang Y, Schaefer K, Walker S, Buckley J, et al. Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease. J Allergy Clin Immunol. 2017;139:1496-1507.e3 pubmed publisher
    Genome-wide association studies have identified the ORM (yeast)-like protein isoform 3 (ORMDL3) gene locus on human chromosome 17q to be a highly significant risk factor for childhood-onset asthma...
  48. Zhang H, Zhuang L, Jin R, Li N, Zhou G. [Recombinant platanus pollen allergen 2 (rPla a2) up-regulates the expression of ORMDL3 mediated by GATA3 in NIH3T3 cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:27-32 pubmed
    ..of recombinant platanus pollen allergen 2 (rPla a2) on the transcription and expression of orosomucoid 1-like 3 (ORMDL3) gene in NIH3T3 cells...
  49. Dang J, Bian X, Ma X, Li J, Long F, Shan S, et al. ORMDL3 Facilitates the Survival of Splenic B Cells via an ATF6?-Endoplasmic Reticulum Stress-Beclin1 Autophagy Regulatory Pathway. J Immunol. 2017;199:1647-1659 pubmed publisher
    The genetic association of orosomucoid-like 3 (ORMDL3) with an array of immunoinflammatory disorders has been recently unraveled in multiple ethnic groups, and functional exploration has received attention of the particular relevance of ..
  50. Andiappan A, Sio Y, Lee B, Suri B, Matta S, Lum J, et al. Functional variants of 17q12-21 are associated with allergic asthma but not allergic rhinitis. J Allergy Clin Immunol. 2016;137:758-66.e3 pubmed publisher
    ..to measure the effect of putative promoter SNPs on expression of the asthma-associated orosomucoid-like 3 gene (ORMDL3). Within 17q12-21, only the tag SNP rs8076131 was significantly associated with asthma (P = 8...
  51. Ono J, Worgall T, Worgall S. Airway reactivity and sphingolipids-implications for childhood asthma. Mol Cell Pediatr. 2015;2:13 pubmed publisher
    ..Orosomucoid-like 3 gene (ORMDL3) and the asthma susceptibility locus 17q21 have been strongly and reproducibly linked to childhood asthma, but how ..
  52. Liu A, Anderson W, Dutmer C, Searing D, Szefler S. Advances in asthma 2015: Across the lifespan. J Allergy Clin Immunol. 2016;138:397-404 pubmed publisher
    ..pathways underlying asthma exacerbations, such as cadherin-related family member 3 (CDHR3) and orosomucoid like 3 (ORMDL3), were elucidated...
  53. Lu Y, Xu J, Zhang X, Zhao X. Gu-Ben-Fang-Xiao decoction attenuates sustained airway inflammation by suppressing ER stress response in a murine asthma remission model of respiratory syncytial virus infection. J Ethnopharmacol. 2016;192:496-509 pubmed publisher
    ..We previously demonstrated that GBFXD could downregulate the asthma susceptibility gene ORMDL3, a trigger of Endoplasmic reticulum (ER) stress and unfolded protein response (UPR)...
  54. Cai X, Huang W, Liu X, Wang L, Jiang Y. Association of novel polymorphisms in TMEM39A gene with systemic lupus erythematosus in a Chinese Han population. BMC Med Genet. 2017;18:43 pubmed publisher
    ..to assess the association between 14 single nucleotide polymorphisms (SNPs) in six genes (IRF8, TMEM39A, IKZF3, ORMDL3, GSDMB, and ZPBP2) and systemic lupus erythematosus (SLE) in a Chinese Han population sample...
  55. Tomita K, Sakashita M, Hirota T, Tanaka S, Masuyama K, Yamada T, et al. Variants in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population. Allergy. 2013;68:92-100 pubmed publisher
    ..Although it is well established that the ORMDL3 locus at chromosome 17q21 is associated with susceptibility to bronchial asthma, the genetic influences of the ..
  56. Wang H, Wong T, Wang L, Su H, Yu H, Wu A, et al. Aryl hydrocarbon receptor signaling promotes ORMDL3-dependent generation of sphingosine-1-phosphate by inhibiting sphingosine-1-phosphate lyase. Cell Mol Immunol. 2018;: pubmed publisher
    ..of S1PL at residue 317, which was reversible by the addition of an antioxidant or in cells with knockdown of the ORMDL3 gene encoding an ER transmembrane protein, whereas C317A S1PL mutant-transfected cells were resistant to the AhR-..
  57. Mells G, Floyd J, Morley K, Cordell H, Franklin C, Shin S, et al. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. Nat Genet. 2011;43:329-32 pubmed publisher
    ..New candidate genes include STAT4, DENND1B, CD80, IL7R, CXCR5, TNFRSF1A, CLEC16A and NFKB1. This study has considerably expanded our knowledge of the genetic architecture of PBC. ..
  58. Yang W, Jin R, Jiang C, Wang X, Shu J, Li L, et al. E3 ubiquitin ligase Cbl-b suppresses human ORMDL3 expression through STAT6 mediation. FEBS Lett. 2015;589:1975-80 pubmed publisher
    Orosomucoid 1-Like Protein 3 (ORMDL3) is an asthma candidate gene and Casitas B lineage lymphoma b (Cbl-b), an E3 ubiquitin ligase, is a critical factor in maintaining airway immune tolerance...
  59. Kaser A, Blumberg R. Autophagy, microbial sensing, endoplasmic reticulum stress, and epithelial function in inflammatory bowel disease. Gastroenterology. 2011;140:1738-47 pubmed publisher
    ..of misfolded proteins, which is genetically related to ulcerative colitis and Crohn's disease (XBP1 and ORMDL3)...
  60. Repnik K, Potočnik U. eQTL analysis links inflammatory bowel disease associated 1q21 locus to ECM1 gene. J Appl Genet. 2016;57:363-72 pubmed publisher
    ..of selected chromosomal regions, we confirmed a link between SNP and gene for four (SLC22A5 on 5q, ECM1 on 1q, ORMDL3 on 17q, and PUS10 on 2p locus) out of five selected regions...
  61. Yang A, Huang R, Jin S. [ORMDL3 polymorphisms and their relationship with OPN and TGF-?1 levels in children with asthma in Hunan, China: an analysis of 98 cases]. Zhongguo Dang Dai Er Ke Za Zhi. 2016;18:324-8 pubmed
    To investigate ORMDL3 polymorphisms in children with asthma in Hunan, China, and to determine the relationship between ORMDL3 polymorphisms and serum osteopontin (OPN) and transforming growth factor-?1 (TGF-?1) levels...
  62. Jin R, Yuan W, Xu H, Ren W, Zhuang L, Zhou G. Characterization of a novel isoform of the human ORMDL3 gene. Cell Tissue Res. 2011;346:203-8 pubmed publisher
    The locus on chromosome 17q21, that encompasses the orosomucoid 1-like protein 3 (ORMDL3) gene, was considered a susceptibility locus associated to asthma, ulcerative colitis and ankylosing spondylitis, and polymorphisms within this locus ..
  63. Kang M, Yu H, Seo J, Kim H, Jung Y, Kim Y, et al. GSDMB/ORMDL3 variants contribute to asthma susceptibility and eosinophil-mediated bronchial hyperresponsiveness. Hum Immunol. 2012;73:954-9 pubmed publisher
    In 2007, a genome-wide association study identified associations between variants involved in the regulation of ORMDL3 expression and asthma. These observations were subsequently replicated in case-control studies in several ethnic groups...
  64. Li M, Zhang S, Qiu Y, He Y, Chen B, Mao R, et al. Upregulation of miR-665 promotes apoptosis and colitis in inflammatory bowel disease by repressing the endoplasmic reticulum stress components XBP1 and ORMDL3. Cell Death Dis. 2017;8:e2699 pubmed publisher
    ..immunoprecipitation were performed to determine that miR-665 directly repressed XBP1 (X-box-binding protein-1) and ORMDL3 expression. Herein, our results revealed that miR-665 was markedly upregulated in active colitis...
  65. Plagnol V, Howson J, Smyth D, Walker N, Hafler J, Wallace C, et al. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genet. 2011;7:e1002216 pubmed publisher
    ..Analysis of the TPOA-associated loci in 2,477 cases with Graves' disease identified two new AITD loci (BACH2 and UBASH3A). ..
  66. Hrdlickova B, Holla L. Relationship between the 17q21 locus and adult asthma in a Czech population. Hum Immunol. 2011;72:921-5 pubmed publisher
    ..We selected tagging single nucleotide polymorphisms (SNPs) in the ORMDL3 gene (17q12) to investigate gene variability in relation to adult allergic asthma and asthma/atopy traits in a ..
  67. Siow D, Wattenberg B. Mammalian ORMDL proteins mediate the feedback response in ceramide biosynthesis. J Biol Chem. 2012;287:40198-204 pubmed publisher
    ..We were unable to detect a role for SMSr in regulating ceramide biosynthesis. We suggest that the role of SMSr may be in the regulation of downstream metabolism of ceramide. ..
  68. Zhakupova A, Debeuf N, Krols M, Toussaint W, Vanhoutte L, Alecu I, et al. ORMDL3 expression levels have no influence on the activity of serine palmitoyltransferase. FASEB J. 2016;30:4289-4300 pubmed
    ..Several single-nucleotide polymorphisms (SNPs) that are close to the ORMDL3 locus have been reported to increase ORMDL3 expression and to be associated with an elevated risk for early ..
  69. Song Y, Schwager M, Backer V, Guo J, Porsbjerg C, Khoo S, et al. Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes. Sci Rep. 2017;7:6342 pubmed publisher
    ..evaluated 18 single nucleotide polymorphisms (SNPs) corresponding to 8 genes (ADAM33, ALOX5, LT-α, LTC4S, NOS1, ORMDL3, TBXA2R and TNF-α), the lung function and five respiratory/allergic conditions (ever asthma, bronchitis, rhinitis,..
  70. Duong Thi Ly H, Nguyen Thi Thu H, Nguyen Hoang L, Nguyen Thi Bich H, Craig T, Duong Quy S. Effects of genetic factors to inhaled corticosteroid response in children with asthma: a literature review. J Int Med Res. 2017;45:1818-1830 pubmed publisher
    ..glucocorticoid induced 1 (GLCCI1), histone deacetylase 1 (HDAC), ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3), and vascular endothelial growth factors (VEGF) directly affect this variability through the anti-inflammatory ..
  71. Gupta S, Gable K, Alexaki A, Chandris P, Proia R, Dunn T, et al. Expression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cells. J Biol Chem. 2015;290:90-8 pubmed publisher
  72. Zhai W, Song C, Huang Z, Sha H. Correlation between the genetic polymorphism of ORMDL3 gene and asthma risk: a meta-analysis. Genet Mol Res. 2015;14:7101-12 pubmed publisher
    While increasing scientific evidence suggests that the ORMDL3 rs7216389 polymorphism may contribute to a higher susceptibility to asthma, many of the current studies have yielded inconclusive results...
  73. Pranculiene G, Steponaitiene R, Skieceviciene J, Kucinskiene R, Kiudelis G, Adamonis K, et al. Associations between NOD2, IRGM and ORMDL3 polymorphisms and pediatric-onset inflammatory bowel disease in the Lithuanian population. Medicina (Kaunas). 2016;52:325-330 pubmed publisher
    ..The aim of this study was to assess the association between NOD2, IL23R, ATG16L1, IRGM, IL10, NKX2-3 and ORMDL3 variants and early-onset IBD...
  74. Balantic M, Rijavec M, Flezar M, Camlek T, Hudoklin I, Kosnik M, et al. A polymorphism in ORMDL3 is associated not only with asthma without rhinitis but also with chronic obstructive pulmonary disease. J Investig Allergol Clin Immunol. 2013;23:256-61 pubmed
    ..of this study was to assess the association between the polymorphism rs4795405 in the known asthma candidate gene ORMDL3 and asthma with and without rhinitis...
  75. Qiu R, Zhang H, Zhao H, Li J, Guo C, Gong Y, et al. Genetic variants on 17q21 are associated with ankylosing spondylitis susceptibility and severity in a Chinese Han population. Scand J Rheumatol. 2013;42:469-72 pubmed publisher
    The aim of this study was to test whether orosomucoid like 3 (ORMDL3) and 17q21 variants are associated with susceptibility to ankylosing spondylitis (AS) in a Chinese population.
  76. Liu X, Ren L, Zhou L, Xiao Q, Deng Y, Liu E. ORMDL3 variants associated with bronchiolitis susceptibility in a Chinese population. Genet Mol Res. 2015;14:19155-62 pubmed publisher
    ..Genome-wide association studies revealed that rs7216389 in the ORMDL3 gene is associated with childhood asthma...
  77. Jang Y, Lee A, Kim J, Jeong S, Kim J, Cho M. Benomyl-induced effects of ORMDL3 overexpression via oxidative stress in human bronchial epithelial cells. Food Chem Toxicol. 2016;98:100-106 pubmed publisher
    ..In this study, we investigated the in vitro effects of benomyl-induced ORMDL3 overexpression on the toxicological mechanism using the human bronchial epithelial cell line 16HBE14o-...
  78. Leung T, Sy H, Ng M, Chan I, Wong G, Tang N, et al. Asthma and atopy are associated with chromosome 17q21 markers in Chinese children. Allergy. 2009;64:621-8 pubmed publisher
    ..asthma but not atopy in Caucasians, with the strongest signal being detected for the SNP rs7216389 in the ORMDL3 gene. Such association was unknown in Chinese...
  79. Kavalar M, Balantic M, Silar M, Kosnik M, Korosec P, Rijavec M. Association of ORMDL3, STAT6 and TBXA2R gene polymorphisms with asthma. Int J Immunogenet. 2012;39:20-5 pubmed publisher
    ..One of the most replicated asthma candidate genes is ORM1-like 3 (Saccharomyces cerevisiae) (ORMDL3), which has been associated with childhood asthma susceptibility...
  80. Nakamura M, Nishida N, Kawashima M, Aiba Y, Tanaka A, Yasunami M, et al. Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. Am J Hum Genet. 2012;91:721-8 pubmed publisher
  81. Wang B, Wang G, Chen D, Wang W, Huang J, Rong J, et al. [Association of ORMDL3 single nucleotide polymorphisms with lysophosphatidylcholine and apolipoprotein B levels in children with asthma]. Zhongguo Dang Dai Er Ke Za Zhi. 2015;17:241-4 pubmed
    To study the association of ORMDL3 single nucleotide polymorphisms (SNP) with lysophosphatidylcholine (LysoPC) and apolipoprotein B (apoB) levels...
  82. Jamieson K, Warner S, Leigh R, Proud D. Rhinovirus in the Pathogenesis and Clinical Course of Asthma. Chest. 2015;148:1508-1516 pubmed publisher
    ..This article reviews the current understanding of the role HRV infections play in the pathogenesis of asthma and identifies possible avenues to new therapeutic strategies for limiting the effects of HRV infections in asthma. ..
  83. Song D, Miller M, Beppu A, Rosenthal P, Das S, Karta M, et al. Rhinovirus Infection of ORMDL3 Transgenic Mice Is Associated with Reduced Rhinovirus Viral Load and Airway Inflammation. J Immunol. 2017;199:2215-2224 pubmed publisher
    Orosomucoid like 3 (ORMDL3), a gene localized to chromosome 17q21, has been linked in epidemiologic studies to childhood asthma and rhinovirus (RV) infections...
  84. Chen J, Miller M, Unno H, Rosenthal P, Sanderson M, Broide D. Orosomucoid-like 3 (ORMDL3) upregulates airway smooth muscle proliferation, contraction, and Ca2+ oscillations in asthma. J Allergy Clin Immunol. 2018;142:207-218.e6 pubmed publisher
    ..We investigated whether increased ASM expression of orosomucoid-like 3 (ORMDL3), a gene on chromosome 17q21 highly linked to asthma, induced increased ASM proliferation and contractility in ..
  85. Dobbins S, Hosking F, Shete S, Armstrong G, Swerdlow A, Liu Y, et al. Allergy and glioma risk: test of association by genotype. Int J Cancer. 2011;128:1736-40 pubmed publisher
    ..0 × 10(-7) . The SNP rs7216389, which tags the 3' flanking region of ORMDL3 at 17q21 and has been associated with childhood asthma, was correlated with increased glioma risk (OR = 1...
  86. Wan Y, Shrine N, Soler Artigas M, Wain L, Blakey J, Moffatt M, et al. Genome-wide association study to identify genetic determinants of severe asthma. Thorax. 2012;67:762-8 pubmed
    ..The strongest evidence was seen for the ORMDL3/GSDMB locus on chromosome 17q12-21 (rs4794820, p=1...
  87. Yang F, Huang Y, Li Q, Dai J, Fu Z. Single nucleotide polymorphisms in the ORM1-like 3 gene associated with childhood asthma in a Chinese population. Genet Mol Res. 2012;11:4646-53 pubmed publisher
    ..polymorphism (SNP)-based genome-wide association studies have revealed that polymorphisms of the ORM1-like 3 (ORMDL3) gene are associated with childhood asthma...
  88. Qiu R, Yang Y, Zhao H, Li J, Xin Q, Shan S, et al. Signal transducer and activator of transcription 6 directly regulates human ORMDL3 expression. FEBS J. 2013;280:2014-26 pubmed publisher
    Orosomucoid-like 3 (ORMDL3) has been associated with asthma and a series of autoimmune disorders, and is involved in endoplasmic reticulum-mediated inflammatory responses...
  89. Siow D, Sunkara M, Dunn T, Morris A, Wattenberg B. ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis. J Lipid Res. 2015;56:898-908 pubmed publisher
    ..studies have established a strong correlation between elevated expression of the endoplasmic reticulum protein ORMDL3 and risk for childhood asthma...
  90. Ma X, Qiu R, Dang J, Li J, Hu Q, Shan S, et al. ORMDL3 contributes to the risk of atherosclerosis in Chinese Han population and mediates oxidized low-density lipoprotein-induced autophagy in endothelial cells. Sci Rep. 2015;5:17194 pubmed publisher
    ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) is a universally confirmed susceptibility gene for asthma and has recently emerged as a crucial modulator in lipid metabolism, inflammation and endoplasmic reticulum (ER) stress-the ..
  91. Zhuang L, Huang B, Feng J, Zhu L, Jin R, Qiu L, et al. All-trans retinoic acid modulates ORMDL3 expression via transcriptional regulation. PLoS ONE. 2013;8:e77304 pubmed publisher
    ..b>ORMDL3 is a candidate gene of childhood onset asthma, and high-transcript of ORMDL3 is associated with the development of ..
  92. Yu X, Yu C, Ren Z, Deng Y, Song J, Zhang H, et al. Genetic variants of 17q21 are associated with childhood-onset asthma and related phenotypes in a northeastern Han Chinese population: a case-control study. Tissue Antigens. 2014;83:330-6 pubmed publisher
    ..04; recessive, P=0.03; additive, P=0.02). Collectively, our findings suggest that orosomucoid 1-like 3 (ORMDL3) locus on chromosome 17q21 is a risk factor for childhood-onset asthma in northeastern Han Chinese population...