Research Topics

Genomes and Genes

ORF66

Summary

Gene Symbol: ORF66
Description: tegument protein; phosphorylates nuclear egress lamina protein; mediates phosphorylation of HDAC1 and HDAC2 and other cellular and viral proteins
Alias: tegument protein, phosphorylates nuclear egress lamina protein, mediates phosphorylation of HDAC1 and HDAC2 and other cellular and viral proteins, serine/threonine protein kinase US3
Species: Human herpesvirus 3

Top Publications

  1. Erazo A, Yee M, Osterrieder N, Kinchington P. Varicella-zoster virus open reading frame 66 protein kinase is required for efficient viral growth in primary human corneal stromal fibroblast cells. J Virol. 2008;82:7653-65 pubmed publisher
    Varicella-zoster virus (VZV) open reading frame 66 (ORF66) encodes a serine/threonine protein kinase that is not required for VZV growth in most cell types but is needed for efficient growth in T cells...
  2. Folster J, Jensen N, Ruyechan W, Inoue N, Schmid D. Regulation of the expression of the varicella-zoster virus open reading frame 66 gene. Virus Res. 2011;155:334-42 pubmed publisher
    ..We examined the regulation of expression of the ORF66 gene by mapping the promoter region, which was localized to within 150 bases of the start codon...