ORF61

Summary

Gene Symbol: ORF61
Description: contains a RING finger; disrupts ND10; proteasome-dependent degradation of several cellular proteins
Alias: contains a RING finger, disrupts ND10, proteasome-dependent degradation of several cellular proteins, ubiquitin E3 ligase ICP0
Species: Human herpesvirus 3

Top Publications

  1. Wang L, Sommer M, Rajamani J, Arvin A. Regulation of the ORF61 promoter and ORF61 functions in varicella-zoster virus replication and pathogenesis. J Virol. 2009;83:7560-72 pubmed publisher
    Varicella-zoster virus (VZV) open reading frame 61 (ORF61) encodes a protein that transactivates viral and cellular promoters in transient-transfection assays and is the ortholog of herpes simplex virus ICP0...
  2. Walters M, Kyratsous C, Silverstein S. The RING finger domain of Varicella-Zoster virus ORF61p has E3 ubiquitin ligase activity that is essential for efficient autoubiquitination and dispersion of Sp100-containing nuclear bodies. J Virol. 2010;84:6861-5 pubmed publisher
    ..In addition, we demonstrate that an intact ORF61p RING finger domain is necessary for E3 ubiquitin ligase activity and is required for autoubiquitination and regulation of protein stability. ..
  3. Sloan E, Henriquez R, Kinchington P, Slobedman B, Abendroth A. Varicella-zoster virus inhibition of the NF-?B pathway during infection of human dendritic cells: role for open reading frame 61 as a modulator of NF-?B activity. J Virol. 2012;86:1193-202 pubmed publisher
    ..An NF-?B reporter assay identified VZV open reading frame 61 (ORF61) as an inhibitor of tumor necrosis factor alpha-induced NF-?B reporter activity...
  4. Zhu H, Zheng C, Xing J, Wang S, Li S, Lin R, et al. Varicella-zoster virus immediate-early protein ORF61 abrogates the IRF3-mediated innate immune response through degradation of activated IRF3. J Virol. 2011;85:11079-89 pubmed publisher
    ..Here we report that its immediate-early protein ORF61 antagonizes the beta interferon (IFN-?) pathway...
  5. Wang L, Rajamani J, Sommer M, Zerboni L, Arvin A. Identification of a hydrophobic domain in varicella-zoster virus ORF61 necessary for ORF61 self-interaction, viral replication, and skin pathogenesis. J Virol. 2013;87:4075-9 pubmed publisher
    The varicella-zoster virus (VZV) ORF61 protein is necessary for normal replication in vitro and virulence in human skin xenografts in the severe combined immunodeficiency mouse model in vivo...
  6. Yamamoto T, Ali M, Liu X, Cohen J. Activation of H2AX and ATM in varicella-zoster virus (VZV)-infected cells is associated with expression of specific VZV genes. Virology. 2014;452-453:52-8 pubmed publisher
    ..phosphorylated H2AX and phosphorylated ATM and that these levels increased in cells infected with VZV deleted for ORF61 or ORF63, but not deleted for ORF67...
  7. Wang L, Oliver S, Sommer M, Rajamani J, Reichelt M, Arvin A. Disruption of PML nuclear bodies is mediated by ORF61 SUMO-interacting motifs and required for varicella-zoster virus pathogenesis in skin. PLoS Pathog. 2011;7:e1002157 pubmed publisher
    ..infected cells in human skin xenografts in SCID mice and that the disruption is achieved by open reading frame 61 (ORF61) protein via its SUMO-interacting motifs (SIMs)...
  8. Rahaus M, Desloges N, Wolff M. ORF61 protein of Varicella-zoster virus influences JNK/SAPK and p38/MAPK phosphorylation. J Med Virol. 2005;76:424-33 pubmed
    ..The viral protein encoded by ORF61 is a major effector of JNK/SAPK and p38/MAPK phosphorylation...
  9. Kyratsous C, Walters M, Panagiotidis C, Silverstein S. Complementation of a herpes simplex virus ICP0 null mutant by varicella-zoster virus ORF61p. J Virol. 2009;83:10637-43 pubmed publisher
    ..This analysis permitted us to compare the activities of ICP0 and ORF61p in identical backgrounds and revealed distinct biologic roles for these proteins...