Gene Symbol: ORF4
Description: RNA-binding protein; shuttles between nucleus and cytoplasm; inhibits pre-mRNA splicing; exports virus mRNA from nucleus; exerts most effects post-transcriptionally
Alias: RNA-binding protein, shuttles between nucleus and cytoplasm, inhibits pre-mRNA splicing, exports virus mRNA from nucleus, exerts most effects post-transcriptionally, multifunctional expression regulator
Species: Human herpesvirus 3

Top Publications

  1. Ambagala A, Bosma T, Ali M, Poustovoitov M, Chen J, Gershon M, et al. Varicella-zoster virus immediate-early 63 protein interacts with human antisilencing function 1 protein and alters its ability to bind histones h3.1 and h3.3. J Virol. 2009;83:200-9 pubmed publisher
    ..Since ASF1 mediates eviction and deposition of histones during transcription, the interaction of VZV IE63 with ASF1 may help to regulate transcription of viral or cellular genes during lytic and/or latent infection...