ORF31

Summary

Gene Symbol: ORF31
Description: type 1 membrane protein; contains a signal peptide; possible membrane fusogen; binds cell surface heparan sulphate
Alias: type 1 membrane protein, contains a signal peptide, possible membrane fusogen, binds cell surface heparan sulphate, envelope glycoprotein B
Species: Human herpesvirus 3

Top Publications

  1. Oliver S, Sommer M, Zerboni L, Rajamani J, Grose C, Arvin A. Mutagenesis of varicella-zoster virus glycoprotein B: putative fusion loop residues are essential for viral replication, and the furin cleavage motif contributes to pathogenesis in skin tissue in vivo. J Virol. 2009;83:7495-506 pubmed publisher
    ..This is the first evidence that cleavage of a herpesvirus fusion protein contributes to viral pathogenesis in vivo, as seen for fusion proteins in other virus families...
  2. Oliver S, Brady J, Sommer M, Reichelt M, Sung P, Blau H, et al. An immunoreceptor tyrosine-based inhibition motif in varicella-zoster virus glycoprotein B regulates cell fusion and skin pathogenesis. Proc Natl Acad Sci U S A. 2013;110:1911-6 pubmed publisher
  3. Maresova L, Pasieka T, Homan E, Gerday E, Grose C. Incorporation of three endocytosed varicella-zoster virus glycoproteins, gE, gH, and gB, into the virion envelope. J Virol. 2005;79:997-1007 pubmed publisher
    ..Furthermore, since a recombinant VZV genome lacking only endocytosis-competent gE cannot replicate, these results supported the conclusion that the endocytosis-envelopment pathway is an essential component of the VZV life cycle...
  4. Oliver S, Yang E, Arvin A. Dysregulated Glycoprotein B-Mediated Cell-Cell Fusion Disrupts Varicella-Zoster Virus and Host Gene Transcription during Infection. J Virol. 2017;91: pubmed
    ..These studies reveal mechanisms central to VZV pathogenesis, potentially leading to improved therapies. ..
  5. Yang E, Arvin A, Oliver S. The Glycoprotein B Cytoplasmic Domain Lysine Cluster Is Critical for Varicella-Zoster Virus Cell-Cell Fusion Regulation and Infection. J Virol. 2017;91: pubmed
    ..The findings further elucidate how VZV self-regulates multinuclear cell formation and may provide insight into the development of new PHN therapies. ..