Gene Symbol: OPRD1
Description: opioid receptor delta 1
Alias: OPRD, delta-type opioid receptor, D-OR-1, DOR-1, delta opioid receptor 1
Species: human
Products:     OPRD1

Top Publications

  1. Gomes I, Jordan B, Gupta A, Trapaidze N, Nagy V, Devi L. Heterodimerization of mu and delta opioid receptors: A role in opiate synergy. J Neurosci. 2000;20:RC110 pubmed
    ..Taken together, these studies show that heterodimers exhibit distinct ligand binding and signaling characteristics. These findings have important clinical ramifications and may provide new foundations for more effective therapies. ..
  2. Gelernter J, Kranzler H. Variant detection at the delta opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence. Hum Genet. 2000;107:86-8 pubmed
    The three opioid receptor genes, and in particular the mu and delta loci (OPRM1 and OPRD1, respectively), are compelling candidates to influence risk for substance dependence...
  3. McVey M, Ramsay D, Kellett E, Rees S, Wilson S, Pope A, et al. Monitoring receptor oligomerization using time-resolved fluorescence resonance energy transfer and bioluminescence resonance energy transfer. The human delta -opioid receptor displays constitutive oligomerization at the cell surface, which is not reg. J Biol Chem. 2001;276:14092-9 pubmed
    ..However, these are not regulated by ligand occupancy. They also indicate that time-resolved fluorescence resonance energy transfer represents a means to detect such oligomers at the cell surface in populations of intact cells. ..
  4. Pello O, Martínez Muñoz L, Parrillas V, Serrano A, Rodríguez Frade J, Toro M, et al. Ligand stabilization of CXCR4/delta-opioid receptor heterodimers reveals a mechanism for immune response regulation. Eur J Immunol. 2008;38:537-49 pubmed publisher
    ..Knockdown of CXCR4 and DOR signaling by heterodimerization might have repercussions on physiological and pathological processes such as inflammation, pain sensation and HIV-1 infection. ..
  5. Décaillot F, Befort K, Filliol D, Yue S, Walker P, Kieffer B. Opioid receptor random mutagenesis reveals a mechanism for G protein-coupled receptor activation. Nat Struct Biol. 2003;10:629-36 pubmed
    ..N- and C-terminal determinants also influence receptor activity. Findings for this therapeutically important receptor may apply to other GPCRs that respond to diffusible ligands. ..
  6. Wang K, Zhang H, Bloss C, Duvvuri V, Kaye W, Schork N, et al. A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa. Mol Psychiatry. 2011;16:949-59 pubmed publisher
    ..We confirmed that common single-nucleotide polymorphisms (SNPs) within OPRD1 (rs533123, P=0...
  7. Xu K, Liu X, Nagarajan S, Gu X, Goldman D. Relationship of the delta-opioid receptor gene to heroin abuse in a large Chinese case/control sample. Am J Med Genet. 2002;110:45-50 pubmed
    ..Previously, two single nucleotide polymorphisms (SNPs), OPRD1 921T > C and 80G > T, of the human delta opioid receptor gene were used in population-based studies of ..
  8. Suzuki S, Chuang L, Yau P, Doi R, Chuang R. Interactions of opioid and chemokine receptors: oligomerization of mu, kappa, and delta with CCR5 on immune cells. Exp Cell Res. 2002;280:192-200 pubmed
    ..These results suggest that oligomerization of chemokine receptor CCR5 and opioid receptors on the cell membrane of human or monkey lymphocytes may modulate receptor functions. ..
  9. Loh E, Fann C, Chang Y, Chang C, Cheng A. Endogenous opioid receptor genes and alcohol dependence among Taiwanese Han. Alcohol Clin Exp Res. 2004;28:15-9 pubmed
    ..situations, and several association studies have examined possible roles of opioid receptor mu (OPRM), delta (OPRD), and kappa (OPRK) genes in the development of alcohol dependence...

More Information

Publications126 found, 100 shown here

  1. Xuei X, Flury Wetherill L, Bierut L, Dick D, Nurnberger J, Foroud T, et al. The opioid system in alcohol and drug dependence: family-based association study. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:877-84 pubmed
    ..We analyzed 18 OPRM1 SNPs, 18 OPRD1 SNPs, 7 PENK SNPs, and 7 POMC SNPs in a sample of 1923 European Americans from 219 multiplex alcohol dependent ..
  2. Zhang H, Kranzler H, Yang B, Luo X, Gelernter J. The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. Mol Psychiatry. 2008;13:531-43 pubmed
    Eleven single-nucleotide polymorphisms (SNPs) spanning OPRD1 were examined in 1063 European Americans (EAs) (620 cases with substance dependence (SD), including 557 with alcohol dependence (AD), 225 with cocaine dependence (CD) and 111 ..
  3. Salusso A, Raimunda D. Defining the Roles of the Cation Diffusion Facilitators in Fe2+/Zn2+ Homeostasis and Establishment of Their Participation in Virulence in Pseudomonas aeruginosa. Front Cell Infect Microbiol. 2017;7:84 pubmed publisher
    ..observations correlated with a lower survival rate upon EDTA-lysozyme treatment and overexpression of OprN and OprD porins...
  4. Clark S, Sinha U, Zhang Y, Wang P, Donaldson S, Coburn B, et al. Penicillin-binding protein 3 is a common adaptive target among Pseudomonas aeruginosa isolates from adult cystic fibrosis patients treated with β-lactams. Int J Antimicrob Agents. 2019;53:620-628 pubmed publisher
    ..6 years. Traditional patterns of ampC or mexA de-repression reduced expression of oprD or the presence of extended-spectrum β-lactamases were not observed in resistant isolates with nonsynonymous ..
  5. Cabot G, Zamorano L, Moyà B, Juan C, Navas A, Blázquez J, et al. Evolution of Pseudomonas aeruginosa Antimicrobial Resistance and Fitness under Low and High Mutation Rates. Antimicrob Agents Chemother. 2016;60:1767-78 pubmed publisher
    ..to AmpC overexpression (ceftazidime), quinolone resistance-determining region (QRDR) mutations (ciprofloxacin), oprD inactivation (meropenem), and efflux pump overexpression (ciprofloxacin and meropenem)...
  6. Sato K, Tsuji A, Usumoto Y, Kudo K, Yokoyama T, Ikeda N. Expression of mRNA in the frontal cortex and hypothalamus in a rat model of acute carbon dioxide poisoning. Leg Med (Tokyo). 2016;19:101-6 pubmed publisher
    ..hypocretin (Hcrt), tyrosine hydroxylase (Th), heat shock protein beta 2 (Hspb2), and opioid receptor delta 1 (Oprd1) expressed in the frontal cortex and renin (Ren), pancreatic polypeptide (Ppy), corticotropin releasing hormone ..
  7. Manohar S, Dahar K, Adler H, Dalian D, Salvi R. Noise-induced hearing loss: Neuropathic pain via Ntrk1 signaling. Mol Cell Neurosci. 2016;75:101-12 pubmed publisher
    ..and inflammatory array, noise exposure upregulated mRNA expression levels of four pain/inflammatory genes, Tlr2, Oprd1, Kcnq3 and Ntrk1 and decreased mRNA expression levels of two more genes, Ccl12 and Il1?...
  8. de Oliveira Santos I, Albano R, Asensi M, D Alincourt Carvalho Assef A. Draft genome sequence of KPC-2-producing Pseudomonas aeruginosa recovered from a bloodstream infection sample in Brazil. J Glob Antimicrob Resist. 2018;15:99-100 pubmed publisher
    ..resistance and virulence found in the genome were blaOXA-50, blaPAO, fosA, catB, mutation in oprD and mexT (MexEF-OprN efflux regulator), and exotoxin-encoding genes (exoS, exoY and exoT)...
  9. Li C, Ye Z, Wen L, Chen R, Tian L, Zhao F, et al. Identification of a novel vaccine candidate by immunogenic screening of Vibrio parahaemolyticus outer membrane proteins. Vaccine. 2014;32:6115-21 pubmed publisher
    ..conserved among major Vibrio species and was proposed to adopt a β-barrel conformation and to be a member of the OprD protein family by bioinformatic analysis...
  10. Zamudio R, Hijazi K, Joshi C, Aitken E, Oggioni M, Gould I. Phylogenetic analysis of resistance to ceftazidime/avibactam, ceftolozane/tazobactam and carbapenems in piperacillin/tazobactam-resistant Pseudomonas aeruginosa from cystic fibrosis patients. Int J Antimicrob Agents. 2019;: pubmed publisher
    ..and/or ceftolozane/tazobactam were resistant to carbapenems and showed inactivating mutations in the chromosomal oprD gene. None of the isolates bore class A, B, D plasmid-encoded carbapenemases...
  11. Atkin S, Abid S, Foster M, Bose M, Keller A, Hollaway R, et al. Multidrug-resistant Pseudomonas aeruginosa from sputum of patients with cystic fibrosis demonstrates a high rate of susceptibility to ceftazidime-avibactam. Infect Drug Resist. 2018;11:1499-1510 pubmed publisher
    ..Ceftazidime-avibactam-resistant strains showed elevated AmpC expression in >60% of the strains and loss of OprD detection in >70% of the strains...
  12. Marguerettaz M, Dieppois G, Que Y, Ducret V, Zuchuat S, Perron K. Sputum containing zinc enhances carbapenem resistance, biofilm formation and virulence of Pseudomonas aeruginosa. Microb Pathog. 2014;77:36-41 pubmed publisher
    ..We identified a novel Zn-sensitive regulatory circuit controlling the expression of the OprD porin and modifying the carbapenem resistance profile...
  13. Zaidenstein R, Miller A, Tal Jasper R, Ofer Friedman H, Sklarz M, Katz D, et al. Therapeutic Management of Pseudomonas aeruginosa Bloodstream Infection Non-Susceptible to Carbapenems but Susceptible to "Old" Cephalosporins and/or to Penicillins. Microorganisms. 2018;6: pubmed publisher
    ..The oprD gene was intact...
  14. Liu C, Chen T, Wang N, Chow S, Lin J, Yan T. Detection of Pseudomonas aeruginosa isolates carrying the blaOXA-142 extended-spectrum β-lactamase gene in Taiwan. J Microbiol Immunol Infect. 2017;50:68-74 pubmed publisher
    ..Eleven strains of P. aeruginosa carrying blaOXA-17 gene were found. The oprD mutation was found in all the 21 ESBL strains of P. aeruginosa...
  15. Greipel L, Fischer S, Klockgether J, Dorda M, Mielke S, Wiehlmann L, et al. Molecular Epidemiology of Mutations in Antimicrobial Resistance Loci of Pseudomonas aeruginosa Isolates from Airways of Cystic Fibrosis Patients. Antimicrob Agents Chemother. 2016;60:6726-6734 pubmed publisher
    ..A high frequency of singular coding variants was seen in spuE, mexA, gyrA, rpoB, fusA1, mexZ, mexY, oprD, ampD, parR, parS, and envZ (amgS), reflecting the pressure upon P...
  16. Kabir M, Meunier D, Hopkins K, Giske C, Woodford N. A two-centre evaluation of RAPIDEC® CARBA NP for carbapenemase detection in Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter spp. J Antimicrob Chemother. 2016;71:1213-6 pubmed publisher
    ..were one Klebsiella oxytoca, which was later found to produce GES-5 carbapenemase, one Pseudomonas aeruginosa with OprD loss and increased efflux, and one Enterobacter cloacae with impermeability...
  17. Persyn E, Sassi M, Aubry M, Broly M, Delanou S, Asehnoune K, et al. Rapid genetic and phenotypic changes in Pseudomonas aeruginosa clinical strains during ventilator-associated pneumonia. Sci Rep. 2019;9:4720 pubmed publisher
    ..For all patients, resistance development was explained by genetic events in ampD, mexR or oprD. Additional variations were detected in virulence- and/or fitness-associated genes (algB, gacA, groEL, lasR, mpl, ..
  18. Ranjitkar S, Jones A, Mostafavi M, Zwirko Z, Iartchouk O, Barnes S, et al. Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 in Pseudomonas aeruginosa PAO1: Uncovering a New Role for MexMN-OprM in Efflux of β-Lactams and a Novel Regulatory Circuit (MmnRS) Controlli. Antimicrob Agents Chemother. 2019;63: pubmed publisher
    ..Expression of oprD, encoding the uptake channel for these compounds, was downregulated, suggesting that this channel is also part ..
  19. Chevalier S, Bouffartigues E, Bodilis J, Maillot O, Lesouhaitier O, Feuilloley M, et al. Structure, function and regulation of Pseudomonas aeruginosa porins. FEMS Microbiol Rev. 2017;41:698-722 pubmed publisher
    ..The remaining nineteen porins belong to the so-called OprD (Occ) family, which is further split into two subfamilies termed OccD (8 members) and OccK (11 members)...
  20. Skalweit M. Profile of ceftolozane/tazobactam and its potential in the treatment of complicated intra-abdominal infections. Drug Des Devel Ther. 2015;9:2919-25 pubmed publisher
    ..aeruginosa, its ability to enter P. aeruginosa through the outer membrane without the utilization of OprD protein, and the fact that it is not a substrate of the often upregulated MexAB/OprM efflux system of P. aeruginosa...
  21. Olesen A, Nielsen L, Feddersen S, Erlenwein J, Petzke F, Przemeck M, et al. Association between genetic polymorphisms and pain sensitivity in patients with hip osteoarthritis. Pain Pract. 2017;: pubmed publisher
    ..of the study was to investigate if genetic variants of mu, kappa, and delta opioid receptor genes (OPRM1, OPRK1, and OPRD1), and the catechol-O-methyltransferase gene (COMT) influenced the pain phenotype in patients with osteoarthritis.
  22. Miyoshi T, Nagai Y, Aizawa T, Kimura K, Watanabe Y. Proteins causing membrane fouling in membrane bioreactors. Water Sci Technol. 2015;72:844-9 pubmed publisher
    ..Brevundimonas or Riemerella anatipestifer) from the foulant obtained from the submerged MBR, and two proteins (OprD and OprF originated from genus Pseudomonas) from that obtained from the side-stream MBR...
  23. Wi Y, Choi J, Lee J, Kang C, Chung D, Peck K, et al. Emergence of colistin resistance in Pseudomonas aeruginosa ST235 clone in South Korea. Int J Antimicrob Agents. 2017;49:767-769 pubmed publisher
    ..type 235 (ST235), and all of the IMP-6-producing isolates showed a deletion of nucleotide 209 of the porin gene oprD. Of the 33 IMP-6-producing ST235 isolates, 9 were resistant to colistin and exhibited resistance to all ..
  24. Tian Y, Guo S, Chen C, Zhao L, Li Z, Yan Y. Gene sequence screening for manganese poisoning-susceptible genes and analysis of gene interaction effects. Environ Toxicol Pharmacol. 2018;64:60-69 pubmed publisher
    ..Sgk1, HCRTr1, HspB1, Rem2, Oprd1, ATF5, and TRHr identified in this study may be involved in oxidative stress mechanisms, dopamine (DA) synthesis, ..
  25. Jaillard M, van Belkum A, Cady K, Creely D, Shortridge D, Blanc B, et al. Correlation between phenotypic antibiotic susceptibility and the resistome in Pseudomonas aeruginosa. Int J Antimicrob Agents. 2017;50:210-218 pubmed publisher
    ..Among these, 29 were variants of the oprD gene associated with variation in meropenem MIC...
  26. Martinez E, Pérez J, Márquez C, Vilacoba E, Centron D, Leal A, et al. Emerging and existing mechanisms co-operate in generating diverse ?-lactam resistance phenotypes in geographically dispersed and genetically disparate Pseudomonas aeruginosa strains. J Glob Antimicrob Resist. 2013;1:135-142 pubmed publisher
    ..Also, gain or loss of IS26 at some chromosomal locations, most notably oprD, could influence resistance to carbapenems...
  27. Lapuebla A, Abdallah M, Olafisoye O, Cortes C, Urban C, Landman D, et al. Activity of Imipenem with Relebactam against Gram-Negative Pathogens from New York City. Antimicrob Agents Chemother. 2015;59:5029-31 pubmed publisher
    ..Enhanced activity was evident against Pseudomonas aeruginosa, including isolates with depressed oprD and increased ampC expression...
  28. Bian Y, He X, Jing Y, Wang L, Wang J, Xie X. Computational systems pharmacology analysis of cannabidiol: a combination of chemogenomics-knowledgebase network analysis and integrated in silico modeling and simulation. Acta Pharmacol Sin. 2019;40:374-386 pubmed publisher
    ..e., 5-hydroxytryptamine receptor 1 A (5HT1A), delta-type opioid receptor (OPRD) and G protein-coupled receptor 55 (GPR55), were selected for close evaluation...
  29. Pragasam A, Raghanivedha M, Anandan S, Veeraraghavan B. Characterization of Pseudomonas aeruginosa with discrepant carbapenem susceptibility profile. Ann Clin Microbiol Antimicrob. 2016;15:12 pubmed publisher
    ..From this study we found that, IRMS is primarily due to the mutations across various regions in the loops of oprD gene and MRIS is due to the over expression of mexAB efflux pumps...
  30. Isabella V, Campbell A, Manchester J, Sylvester M, Nayar A, Ferguson K, et al. Toward the rational design of carbapenem uptake in Pseudomonas aeruginosa. Chem Biol. 2015;22:535-547 pubmed publisher
    ..the first time that these compounds are taken up not only by the major outer membrane channel OccD1 (also called OprD or PA0958) but also by a closely related channel OccD3 (OpdP or PA4501)...
  31. Schiavano G, Carloni E, Andreoni F, Magi S, Chironna M, Brandi G, et al. Prevalence and antibiotic resistance of Pseudomonas aeruginosa in water samples in central Italy and molecular characterization of oprD in imipenem resistant isolates. PLoS ONE. 2017;12:e0189172 pubmed publisher
    ..1,518; municipal waterworks, n. 4,500; residential buildings, n. 235). Possible mechanisms underlying resistance to imipenem, with particular focus on those involving oprD-based uptake, were also explored.
  32. Varin A, Valot B, Cholley P, Morel C, Thouverez M, Hocquet D, et al. High prevalence and moderate diversity of Pseudomonas aeruginosa in the U-bends of high-risk units in hospital. Int J Hyg Environ Health. 2017;220:880-885 pubmed publisher
    ..Analysis of resistance rates showed that the deficiency of porin OprD was very frequent in U-bends isolates that may benefit from this resistance mechanism in hospital water fittings...
  33. Buehrle D, Shields R, Chen L, Hao B, Press E, Alkrouk A, et al. Evaluation of the In Vitro Activity of Ceftazidime-Avibactam and Ceftolozane-Tazobactam against Meropenem-Resistant Pseudomonas aeruginosa Isolates. Antimicrob Agents Chemother. 2016;60:3227-31 pubmed publisher
    ..No isolates harbored carbapenemases; 74% were oprD mutants...
  34. Xiong J, Déraspe M, Iqbal N, Krajden S, Chapman W, Dewar K, et al. Complete Genome of a Panresistant Pseudomonas aeruginosa Strain, Isolated from a Patient with Respiratory Failure in a Canadian Community Hospital. Genome Announc. 2017;5: pubmed publisher
    ..No carbapenemase genes were identified. Carbapenem resistance is attributable to a frameshift in the oprD gene; the basis for colistin resistance remains undetermined.
  35. Hirabayashi A, Kato D, Tomita Y, Iguchi M, Yamada K, Kouyama Y, et al. Risk factors for and role of OprD protein in increasing minimal inhibitory concentrations of carbapenems in clinical isolates of Pseudomonas aeruginosa. J Med Microbiol. 2017;66:1562-1572 pubmed publisher
    ..This study examined the risk factors for, and molecular mechanisms underlying, the increase in carbapenem minimum inhibitory concentrations (MICs) in clinical isolates of Pseudomonas aeruginosa...
  36. Kringel D, Ultsch A, Zimmermann M, Jansen J, Ilias W, Freynhagen R, et al. Emergent biomarker derived from next-generation sequencing to identify pain patients requiring uncommonly high opioid doses. Pharmacogenomics J. 2017;17:419-426 pubmed publisher
    ..Following precisely calculated selection of the 34 most informative markers in the OPRM1, OPRK1, OPRD1 and SIGMAR1 genes, pattern of genotypes belonging to either patient group could be derived using a k-nearest ..
  37. Luo R, Li X, Qin S, Luo Z, Luo X, Hu P, et al. Impact of SNP-SNP interaction among ABCB1, ARRB2, DRD1 and OPRD1 on methadone dosage requirement in Han Chinese patients. Pharmacogenomics. 2017;: pubmed publisher
    To evaluate the potential association of the genetic polymorphisms in ABCB1, ARRB2, DRD1 and OPRD1 genes with methadone dosage requirement among Han Chinese opioid-dependent patients.
  38. Li S, Jia X, Li C, Zou H, Liu H, Guo Y, et al. Carbapenem-resistant and cephalosporin-susceptible Pseudomonas aeruginosa: a notable phenotype in patients with bacteremia. Infect Drug Resist. 2018;11:1225-1235 pubmed publisher
    ..polymerase chain reaction analysis showed that an overexpression of efflux systems and decreased expression of OprD were associated with Carb-R/Ceph-S P. aeruginosa...
  39. Solé M, Fàbrega A, Cobos Trigueros N, Zamorano L, Ferrer Navarro M, Ballesté Delpierre C, et al. In vivo evolution of resistance of Pseudomonas aeruginosa strains isolated from patients admitted to an intensive care unit: mechanisms of resistance and antimicrobial exposure. J Antimicrob Chemother. 2015;70:3004-13 pubmed publisher
    ..Outer membrane protein profiles were assessed to study OprD expression. RT-PCR was performed to analyse ampC, mexB, mexD, mexF and mexY expression...
  40. Samanta S, Scorciapino M, Ceccarelli M. Molecular basis of substrate translocation through the outer membrane channel OprD of Pseudomonas aeruginosa. Phys Chem Chem Phys. 2015;17:23867-76 pubmed publisher
    ..Our focus is to come up with a precise understanding of the structure and dynamics of the outer membrane porin OprD of the Gram-negative bacterium Pseudomonas aeruginosa by studying the translocation of natural amino acid residues/..
  41. Parenty G, Appelbe S, Milligan G. CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2-DOP receptor heterodimer. Biochem J. 2008;412:245-56 pubmed publisher
    ..These results have novel and important implications for the development and use of small-molecule therapeutics. ..
  42. Morgan M, Heffernan A, Benhabib F, Wagner S, Hewavitharana A, Shaw P, et al. The efficacy of Dynorphin fragments at the ?, ? and ? opioid receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation. Peptides. 2017;89:9-16 pubmed publisher
    ..These results show that dynorphin fragments produced in an inflamed tissue homogenate have changed activity at the opioid receptors and that dynorphin 1-7 mediates analgesia. ..
  43. Wi Y, Choi J, Lee J, Kang C, Chung D, Peck K, et al. Antimicrobial Effects of β-Lactams on Imipenem-Resistant Ceftazidime-Susceptible Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..All 18 imipenem-resistant ceftazidime-susceptible isolates showed decreased mRNA expression of oprD, and overexpression of mexB was observed in 13 isolates...
  44. Ellappan K, Belgode Narasimha H, Kumar S. Coexistence of multidrug resistance mechanisms and virulence genes in carbapenem-resistant Pseudomonas aeruginosa strains from a tertiary care hospital in South India. J Glob Antimicrob Resist. 2018;12:37-43 pubmed publisher
    ..Semi-quantitative reverse transcription PCR (RT-PCR) was optimised to evaluate oprD deficiency...
  45. Narita M, Funada M, Suzuki T. Regulations of opioid dependence by opioid receptor types. Pharmacol Ther. 2001;89:1-15 pubmed
  46. Soysa H, Suginta W. Identification and Functional Characterization of a Novel OprD-like Chitin Uptake Channel in Non-chitinolytic Bacteria. J Biol Chem. 2016;291:13622-33 pubmed publisher
    ..In this study we describe the identification and characterization of a novel OprD-like chitoporin (so-called EcChiP) from Escherichia coli The gene was identified, cloned, and functionally ..
  47. Qiu Y, Loh H, Law P. Phosphorylation of the delta-opioid receptor regulates its beta-arrestins selectivity and subsequent receptor internalization and adenylyl cyclase desensitization. J Biol Chem. 2007;282:22315-23 pubmed
    ..Taken together, these results indicate that receptor phosphorylation confers DOR selectivity for beta-arrestin 2 without affecting the stability of the receptor-beta-arrestin complex and the fate of the internalized receptor. ..
  48. Guo J, Wu Y, Zhang W, Zhao J, Devi L, Pei G, et al. Identification of G protein-coupled receptor kinase 2 phosphorylation sites responsible for agonist-stimulated delta-opioid receptor phosphorylation. Mol Pharmacol. 2000;58:1050-6 pubmed
  49. Aguila B, Coulbault L, Davis A, Marie N, Hasbi A, Le Bras F, et al. ßarrestin1-biased agonism at human ?-opioid receptor by peptidic and alkaloid ligands. Cell Signal. 2012;24:699-707 pubmed publisher
    ..Taken together, these results provide substantial evidence for a ßarrestin1-biased agonism at hDOR, where ßarrestin1 is differentially involved during receptor desensitization and endocytosis depending on the ligand. ..
  50. Rozenfeld R, Bushlin I, Gomes I, Tzavaras N, Gupta A, Neves S, et al. Receptor heteromerization expands the repertoire of cannabinoid signaling in rodent neurons. PLoS ONE. 2012;7:e29239 pubmed publisher
  51. Neumann C, Bigliardi Qi M, Widmann C, Bigliardi P. The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3. J Invest Dermatol. 2015;135:471-480 pubmed publisher
    ..Complementing our earlier studies in DOPr-deficient mice, these data suggest that DOPr activation in human keratinocytes profoundly influences epidermal morphogenesis and homeostasis. ..
  52. Huang M, Nguyen V, Wu Y, Rastogi S, Lui C, Birnbaum Y, et al. Reducing ischaemia/reperfusion injury through delta-opioid-regulated intrinsic cardiac adrenergic cells: adrenopeptidergic co-signalling. Cardiovasc Res. 2009;84:452-60 pubmed publisher
  53. Tang B, Li Y, Yuan S, Tomlinson S, He S. Upregulation of the ? opioid receptor in liver cancer promotes liver cancer progression both in vitro and in vivo. Int J Oncol. 2013;43:1281-90 pubmed publisher
    ..In conclusion, DOR is highly expressed in HCC and is involved in HCC progression, suggesting that DOR is a potential target for HCC treatment. ..
  54. Hansell N, Agrawal A, Whitfield J, Morley K, Gordon S, Lind P, et al. Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes?. Alcohol Clin Exp Res. 2009;33:729-39 pubmed publisher
    ..identified in linkage studies and/or containing proposed candidate genes for alcoholism including AGT, CARTPT, OPRD1, PIK3R1, and PDYN...
  55. Salimi V, Hennus M, Mokhtari Azad T, Shokri F, Janssen R, Hodemaekers H, et al. Opioid receptors control viral replication in the airways. Crit Care Med. 2013;41:205-14 pubmed publisher
    ..Two single nucleotide polymorphisms in OPRM1 and OPRD1 were genotyped in 465 infants with severe respiratory syncytial virus infection and 930 control subjects...
  56. Ducret V, Gonzalez M, Scrignari T, Perron K. OprD Repression upon Metal Treatment Requires the RNA Chaperone Hfq in Pseudomonas aeruginosa. Genes (Basel). 2016;7: pubmed
    The metal-specific CzcRS two-component system in Pseudomonas aeruginosa is involved in the repression of the OprD porin, causing in turn carbapenem antibiotic resistance in the presence of high zinc concentration...
  57. Vassilara F, Galani I, Souli M, Papanikolaou K, Giamarellou H, Papadopoulos A. Mechanisms responsible for imipenem resistance among Pseudomonas aeruginosa clinical isolates exposed to imipenem concentrations within the mutant selection window. Diagn Microbiol Infect Dis. 2017;88:276-281 pubmed publisher
    ..of the nine isolates mainly revealed inactivating mutations in the gene coding for outer membrane protein OprD. Point mutations leading to premature stop codons or amino acid substitution S278P, ≥1bp deletion leading to ..
  58. Fraile Ribot P, Mulet X, Cabot G, Del Barrio Tofiño E, Juan C, Perez J, et al. In Vivo Emergence of Resistance to Novel Cephalosporin-β-Lactamase Inhibitor Combinations through the Duplication of Amino Acid D149 from OXA-2 β-Lactamase (OXA-539) in Sequence Type 235 Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..final (98G1) isolates belonged to the high-risk clone sequence type (ST) 235 and were resistant to carbapenems (oprD), fluoroquinolones (GyrA-T83I, ParC-S87L), and aminoglycosides (aacA7/aacA8/aadA6)...
  59. Rostami S, Farajzadeh Sheikh A, Shoja S, Farahani A, Tabatabaiefar M, Jolodar A, et al. Investigating of four main carbapenem-resistance mechanisms in high-level carbapenem resistant Pseudomonas aeruginosa isolated from burn patients. J Chin Med Assoc. 2018;81:127-132 pubmed publisher
    ..of the MexAB-OprM and MexXY efflux pumps, overproduction of chromosome-encoded AmpC β-lactamase, and reduced OprD expression] in high-level carbapenem-resistant P.aeruginosa isolated from patients with burns...
  60. Markkanen P, Petäjä Repo U. N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem. 2008;283:29086-98 pubmed publisher
    ..We conclude that N-glycosylation of the delta-opioid receptor is needed to maintain the expression of fully functional and stable receptor molecules at the cell surface. ..
  61. Macgowan A, Noel A, Tomaselli S, Nicholls D, Bowker K. Pharmacodynamics of Ceftolozane plus Tazobactam Studied in an In Vitro Pharmacokinetic Model of Infection. Antimicrob Agents Chemother. 2016;60:515-21 pubmed publisher
    ..aeruginosa, including two with OprD overexpression and AmpC β-lactamases, were employed. Ceftolozane MICs (E. coli, 0.12 to 0.25 mg/liter, and P...
  62. Kim C, Kang H, Kim B, Jeon H, Lee Y, Lee S, et al. Mutational inactivation of OprD in carbapenem-resistant Pseudomonas aeruginosa isolates from Korean hospitals. J Microbiol. 2016;54:44-49 pubmed publisher
    ..Mutations in the oprD gene and a related decrease in gene expression were found in 21 and 5 isolates, respectively...
  63. Olsen R, Foster D, Upton R, Olesen A, Ross J, Droney J, et al. Modelling the PKPD of oxycodone in experimental pain - Impact of opioid receptor polymorphisms. Eur J Pharm Sci. 2016;86:41-9 pubmed publisher
    ..None of the selected polymorphisms were significantly associated with analgesic response of oxycodone, but an association of baseline response in muscle cuff pressure with two OPRK1 SNPs was identified. ..
  64. Randesi M, van den Brink W, Levran O, Blanken P, Butelman E, Yuferov V, et al. Variants of opioid system genes are associated with non-dependent opioid use and heroin dependence. Drug Alcohol Depend. 2016;168:164-169 pubmed publisher
    ..The association of the delta opioid receptor (OPRD1) intronic SNP rs2236861 with non-dependent opioid use (HC vs...
  65. Feng W, Sun F, Wang Q, Xiong W, Qiu X, Dai X, et al. Epidemiology and resistance characteristics of Pseudomonas aeruginosa isolates from the respiratory department of a hospital in China. J Glob Antimicrob Resist. 2017;8:142-147 pubmed publisher
    ..Amplification and sequencing of the oprD gene were performed for carbapenem-resistant P. aeruginosa...
  66. Abbasloo F, Khosravani S, Ghaedi M, Dashtian K, Hosseini E, Manzouri L, et al. Sonochemical-solvothermal synthesis of guanine embedded copper based metal-organic framework (MOF) and its effect on oprD gene expression in clinical and standard strains of Pseudomonas aeruginosa. Ultrason Sonochem. 2018;42:237-243 pubmed publisher
    ..The effect of prepared material on oprD Gene Expression was investigated in Clinical and Standard Strains of Pseudomonas aeruginosa (PAO-1) and minimum ..
  67. Mikucionyte G, Zamorano L, Vitkauskiene A, López Causapé C, Juan C, Mulet X, et al. Nosocomial dissemination of VIM-2-producing ST235 Pseudomonas aeruginosa in Lithuania. Eur J Clin Microbiol Infect Dis. 2016;35:195-200 pubmed publisher
    ..lactamases were detected in 19 (26 %) of the isolates, whereas resistance was exclusively chromosomal (OprD inactivation ± AmpC hyperproduction) in the remaining 54 (74 %) isolates...
  68. Bhattacharya D, Belperio P, Shahoumian T, Loomis T, Goetz M, Mole L, et al. Effectiveness of All-Oral Antiviral Regimens in 996 Human Immunodeficiency Virus/Hepatitis C Virus Genotype 1-Coinfected Patients Treated in Routine Practice. Clin Infect Dis. 2017;64:1711-1720 pubmed publisher
    ..with or without ribavirin (LDV/SOF ± RBV) and ombitasvir/ paritaprevir/ritonavir plus dasabuvir (OPrD) ± RBV in HIV/HCV genotype 1 (GT1)-coinfected patients initiating HCV therapy in clinical practice...
  69. He J, Jia X, Yang S, Xu X, Sun K, Li C, et al. Heteroresistance to carbapenems in invasive Pseudomonas aeruginosa infections. Int J Antimicrob Agents. 2018;51:413-421 pubmed publisher
    ..Mechanistic analysis revealed that efflux system overexpression and decreased OprD could have contributed to carbapenem heteroresistance in P. aeruginosa...
  70. Bigliardi P, Neumann C, Teo Y, Pant A, Bigliardi Qi M. Activation of the ?-opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration. Br J Pharmacol. 2015;172:501-14 pubmed publisher
    ..This article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-2. ..
  71. Sharafshah A, Fazel H, Albonaim A, Omarmeli V, Rezaei S, Mirzajani E, et al. Association of OPRD1 Gene Variants with Opioid Dependence in Addicted Male Individuals Undergoing Methadone Treatment in the North of Iran. J Psychoactive Drugs. 2017;49:242-251 pubmed publisher
    ..of rs678849 along with neuroimaging and biomarker phenotypes, parallel with the known involvements of the OPRD1 in drug abuse, provided additional support for targeting these receptors as potential therapeutic targets in both ..
  72. Simonin F, Befort K, Gaveriaux Ruff C, Matthes H, Nappey V, Lannes B, et al. The human delta-opioid receptor: genomic organization, cDNA cloning, functional expression, and distribution in human brain. Mol Pharmacol. 1994;46:1015-21 pubmed
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    ..rats in the gene expression of endogenous opioid peptides (Pomc, Penk, Pdyn) and cognate receptors (Oprm, Oprk and Oprd) in reward-related brain regions, after exposure to either cocaine self-administration or yoked-saline, in the ..
  74. Petaja Repo U, Hogue M, Laperriere A, Walker P, Bouvier M. Export from the endoplasmic reticulum represents the limiting step in the maturation and cell surface expression of the human delta opioid receptor. J Biol Chem. 2000;275:13727-36 pubmed
    ..Whether or not the low efficiency of the ER export is a general feature among G protein-coupled receptors remains to be investigated. ..
  75. Alves I, Ciano K, Boguslavski V, Varga E, Salamon Z, Yamamura H, et al. Selectivity, cooperativity, and reciprocity in the interactions between the delta-opioid receptor, its ligands, and G-proteins. J Biol Chem. 2004;279:44673-82 pubmed
    ..Because ligand also influences G-protein binding, reciprocity exists between these two binding processes. ..
  76. Lackman J, Markkanen P, Hogue M, Bouvier M, Petäjä Repo U. N-Glycan-dependent and -independent quality control of human ? opioid receptor N-terminal variants. J Biol Chem. 2014;289:17830-42 pubmed publisher
  77. Kobayashi H, Hata H, Ujike H, Harano M, Inada T, Komiyama T, et al. Association analysis of delta-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:482-6 pubmed
    The role of the delta-opioid receptor (OPRD1) in methamphetamine (MAP) addiction was investigated using association analysis between OPRD1 gene polymorphisms and MAP dependence/psychosis...
  78. Huang C, Liu H, Su N, Hsu Y, Yang C, Chen C, et al. Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females*. Anaesthesia. 2008;63:1288-95 pubmed publisher
    ..e. OPRM1, OPRK1, and OPRD1) genes in 72 healthy adult Taiwanese women of Han Chinese race...
  79. Cen B, Yu Q, Guo J, Wu Y, Ling K, Cheng Z, et al. Direct binding of beta-arrestins to two distinct intracellular domains of the delta opioid receptor. J Neurochem. 2001;76:1887-94 pubmed
    ..This study demonstrated for the first time the direct binding of beta-arrestins to the two distinct domains, the carboxyl terminus and the third intracellular loop, of DOR. ..
  80. Wu E, Wong Y. Activation of delta-, kappa-, and mu-opioid receptors induces phosphorylation of tuberin in transfected HEK 293 cells and native cells. Biochem Biophys Res Commun. 2005;334:838-44 pubmed
    ..This is the first study that demonstrates the regulatory role of opioid receptors on tuberin. ..
  81. Malik S, Khalique H, Buch S, Seth P. A growth factor attenuates HIV-1 Tat and morphine induced damage to human neurons: implication in HIV/AIDS-drug abuse cases. PLoS ONE. 2011;6:e18116 pubmed publisher
    ..We have also showed for the first time that PDGF-BB can protect against simultaneous exposure of Tat and morphine, strengthening its role as a neuroprotective agent that could be considered for therapeutic intervention. ..
  82. Simonin F, Karcher P, Boeuf J, Matifas A, Kieffer B. Identification of a novel family of G protein-coupled receptor associated sorting proteins. J Neurochem. 2004;89:766-75 pubmed
    ..Another member of the family, GASP-2, also interacts with the carboxyl-terminal tail of several GPCRs. Therefore, GASP proteins may represent an important protein family regulating GPCR physiology. ..
  83. Sarajärvi T, Tuusa J, Haapasalo A, Lackman J, Sormunen R, Helisalmi S, et al. Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking. Mol Cell Biol. 2011;31:2326-40 pubmed publisher
    ..These data suggest that an increased constitutive internalization and/or concurrent signaling of the ?OR-Cys27 variant affects APP processing through altered endocytic trafficking of APP. ..
  84. Crist R, Doyle G, Kampman K, Berrettini W. A delta-opioid receptor genetic variant is associated with abstinence prior to and during cocaine dependence treatment. Drug Alcohol Depend. 2016;166:268-71 pubmed publisher
    An intronic polymorphism in the delta-opioid receptor gene (OPRD1) was previously associated with cocaine dependence in African-Americans...
  85. Raavi -, Mishra S, Singh S. Prevention of OprD regulated antibiotic resistance in Pseudomonas aeruginosa biofilm. Microb Pathog. 2017;112:221-229 pubmed publisher
    ..aeruginosa. They both negatively regulate OprD porin expression which affects the intake of antibiotics like carbapenems...
  86. Levran O, Londono D, O Hara K, Nielsen D, Peles E, Rotrosen J, et al. Genetic susceptibility to heroin addiction: a candidate gene association study. Genes Brain Behav. 2008;7:720-9 pubmed publisher
    ..regions of the genes encoding the mu (OPRM1; rs510769 and rs3778151), kappa (OPRK1; rs6473797) and delta (OPRD1; rs2236861, rs2236857 and rs3766951) opioid receptors; the neuropeptide galanin (GAL; rs694066); the serotonin ..
  87. Backus L, Belperio P, Shahoumian T, Loomis T, Mole L. Real-world effectiveness and predictors of sustained virological response with all-oral therapy in 21,242 hepatitis C genotype-1 patients. Antivir Ther. 2017;22:481-493 pubmed publisher
    ..of SVR for ledipasvir/sofosbuvir ± ribavirin (LDV/SOF ±RBV) and ombitasvir/paritaprevir/ritonavir + dasabuvir (OPrD) ±RBV in patients treated in routine practice...
  88. Luo X, Zuo L, Kranzler H, Zhang H, Wang S, Gelernter J. Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1028-39 pubmed publisher
    ..We genotyped 20 OPRM1 markers, 8 OPRD1 markers, and 7 OPRK1 markers, and 38 unlinked ancestry-informative markers in these subjects...
  89. Arias A, Armeli S, Gelernter J, Covault J, Kallio A, Karhuvaara S, et al. Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers. Alcohol Clin Exp Res. 2008;32:1159-66 pubmed publisher
    ..in OPRM1 (including A118G, a commonly studied SNP that encodes an Asn40Asp amino acid substitution), two SNPs in OPRD1, and one SNP in OPRK1, which encode the mu-, delta-, and kappa-opioid receptors, respectively...
  90. Weil C, Mehta D, Koren G, Pinsky B, Samp J, Chodick G, et al. Sustained virological response to ombitasvir/paritaprevir/ritonavir and dasabuvir treatment for hepatitis C: Real-world data from a large healthcare provider. J Viral Hepat. 2018;25:144-151 pubmed publisher
    Treatment with ombitasvir/paritaprevir/ritonavir and dasabuvir, with or without ribavirin (OPrD ± RBV), was the first interferon-free direct-acting antiviral for hepatitis C virus (HCV) introduced to Israel's national basket of health ..
  91. Xiang B, Yu G, Guo J, Chen L, Hu W, Pei G, et al. Heterologous activation of protein kinase C stimulates phosphorylation of delta-opioid receptor at serine 344, resulting in beta-arrestin- and clathrin-mediated receptor internalization. J Biol Chem. 2001;276:4709-16 pubmed
  92. Fadhil I, Schmidt R, Walpole C, Carpenter K. Exploring deltorphin II binding to the third extracellular loop of the delta-opioid receptor. J Biol Chem. 2004;279:21069-77 pubmed
    ..Similar changes did not occur for the shorter peptide hDOR(281-297). A hypothesis describing the conformational events accompanying selective deltorphin II binding to the delta-opioid receptor is presented. ..